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43 results on '"Fujimoto, Mika"'

4. Bullous Pemphigoid in X-linked Alport Syndrome

Author

Yamawaki, Masahiro, primary, Katayama, Kan, additional, Fujimoto, Mika, additional, Goto, Hiroyuki, additional, Yuasa, Hiroto, additional, Kozuka, Yuji, additional, Mori, Mutsuki, additional, Takahashi, Daisuke, additional, Saiki, Ryosuke, additional, Hirabayashi, Yosuke, additional, Murata, Tomohiro, additional, Yamanaka, Keiichi, additional, and Dohi, Kaoru, additional

Published
2023
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7. Mutation Analysis of Thin Basement Membrane Nephropathy

Author

Hirabayashi, Yosuke, primary, Katayama, Kan, additional, Mori, Mutsuki, additional, Matsuo, Hiroshi, additional, Fujimoto, Mika, additional, Joh, Kensuke, additional, Murata, Tomohiro, additional, Ito, Masaaki, additional, and Dohi, Kaoru, additional

Published
2022
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14. A Kidney Transplant Recipient with Recurrent Henoch-Schönlein Purpura Nephritis Successfully Treated with Steroid Pulse Therapy and Epipharyngeal Abrasive Therapy

Author

Fujimoto, Mika, primary, Katayama, Kan, additional, Nishikawa, Kouhei, additional, Mizoguchi, Shoko, additional, Oda, Keiko, additional, Hirabayashi, Yosuke, additional, Suzuki, Yasuo, additional, Haruki, Ayumi, additional, Ito, Takayasu, additional, Murata, Tomohiro, additional, Ishikawa, Eiji, additional, Sugimura, Yoshiki, additional, and Ito, Masaaki, additional

Published
2020
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15. Short-chain fatty acids regulate IGF-binding protein secretion by intestinal epithelial cells

Author

Nishimura, Akiyoshi, Fujimoto, Mika, Oguchi, Satoshi, Fusunyan, Robert D., MacDermott, Richard P., and Sanderson, Ian R.

Subjects
Epithelial cells -- Physiological aspects, Insulin-like growth factors -- Physiological aspects, Fatty acids -- Physiological aspects, Proteins -- Synthesis, Biological sciences
Abstract

A study was conducted to examine the influence of short-chain fatty acids on insulin-like growth factor-binding protein (IGFBP) secretion of intestinal epithelial cells. The experiments were carried out on cells at two stages of differentiation while histones were extracted from Caco-2 cells. Results indicated that intestinal epithelial cells are influenced by short-chain fatty acids that alter the secretion of IGFBPs.

Published
1998

18. Improvement of Alveolar Hemorrhaging in an Elderly and Renally Impaired Patient with Relapsing Anti-neutrophil Cytoplasmic Autoantibody-associated Vasculitis by Single Infusion of Rituximab

Author

Oda, Keiko, primary, Ishikawa, Eiji, additional, Ito, Takayasu, additional, Mizoguchi, Shoko, additional, Hirabayashi, Yosuke, additional, Suzuki, Yasuo, additional, Haruki, Ayumi, additional, Fujimoto, Mika, additional, Murata, Tomohiro, additional, Katayama, Kan, additional, Onishi, Takahiro, additional, and Ito, Masaaki, additional

Published
2018
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20. Tocilizumab for uncontrollable systemic inflammatory response syndrome complicating adult-onset Still disease

Author

Masui-Ito, Asami, Okamoto, Ryuji, Ikejiri, Kaoru, Fujimoto, Mika, Tanimura, Muneyoshi, Nakamori, Shiro, Murata, Tomohiro, Ishikawa, Eiji, Yamada, Norikazu, Imai, Hiroshi, and Ito, Masaaki

Subjects
Adult, interleukin 6, Antibodies, Monoclonal, Humanized, Systemic Inflammatory Response Syndrome, Diagnosis, Differential, adult-onset Still disease, tocilizumab, Humans, Immunologic Factors, Female, Clinical Case Report, Still's Disease, Adult-Onset, Research Article
Abstract

Rationale: Adult-onset Still disease (AOSD) is a rare systemic inflammatory disease of unknown etiology characterized by evanescent salmon-pink rash, fever spikes, arthralgia, and lymphadenopathy. AOSD usually has a good prognosis, but it can sometimes be fatal, especially when it is complicated by systemic inflammatory response syndrome (SIRS) and multiple organ failure. Patient concerns: A previously healthy 26-year-old woman was referred to our hospital for persistent high fever and mild systemic edema. Five days later, the patient presented with dyspnea, hypotension, and anuria. Anasarca developed with massive pleural effusion, ascites, and systemic edema, resulting in an increase of 47 kg in body weight. Diagnoses: The patient was diagnosed as AOSD after infection, malignancy, hematologic disorders, and other autoimmune diseases were excluded. Interventions: We administered tocilizumab, an IL-6 receptor inhibitor, intravenously in addition to cyclosporine, prednisolone, plasma exchange, and continuous hemodiafiltration. Outcomes: The patient's systemic condition improved. After stabilization by all medications, the patient was managed and responded to tocilizumab alone. To the best of our knowledge, this was the first case of severe SIRS complicating AOSD that was successfully treated with an anti- IL-6 receptor antibody. Lessons: SIRS should not be overlooked in a patient with steroid-resistant AOSD and edema. Inhibitors of the IL-6 receptor can be used safely and effectively to control AOSD complicated with severe SIRS.

Published
2017

21. Clinical Manifestation of Patients With Atypical Hemolytic Uremic Syndrome With the C3 p.I1157T Variation in the Kinki Region of Japan

Author

Matsumoto, Takeshi, primary, Toyoda, Hidemi, additional, Amano, Keishirou, additional, Hirayama, Masahiro, additional, Ishikawa, Eiji, additional, Fujimoto, Mika, additional, Ito, Masaaki, additional, Ohishi, Kohshi, additional, Katayama, Naoyuki, additional, Yoshida, Yoko, additional, Matsumoto, Masanori, additional, Kawamura, Naohisa, additional, Ikejiri, Makoto, additional, Kawakami, Keiki, additional, Miyata, Toshiyuki, additional, and Wada, Hideo, additional

Published
2018
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22. The effect of an L/N-type calcium channel blocker on intradialytic blood pressure in intradialytic hypertensive patients

Author

Ito, Takayasu, primary, Fujimoto, Naoki, additional, Ishikawa, Eiji, additional, Dohi, Kaoru, additional, Fujimoto, Mika, additional, Murata, Tomohiro, additional, Kiyohara, Michiyo, additional, Takeuchi, Hideyuki, additional, Koyabu, Sukenari, additional, Nishimura, Hiroyuki, additional, Takeuchi, Toshiaki, additional, and Ito, Masaaki, additional

Published
2018
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24. A Kidney Transplant Recipient with Recurrent Henoch-Schönlein Purpura Nephritis Successfully Treated with Steroid Pulse Therapy and Epipharyngeal Abrasive Therapy

Author

Fujimoto, Mika, Katayama, Kan, Nishikawa, Kouhei, Mizoguchi, Shoko, Oda, Keiko, Hirabayashi, Yosuke, Suzuki, Yasuo, Haruki, Ayumi, Ito, Takayasu, Murata, Tomohiro, Ishikawa, Eiji, Sugimura, Yoshiki, and Ito, Masaaki

Abstract

There is no specific treatment for recurrent Henoch-Schönlein purpura nephritis (HSPN) in a transplanted kidney. We herein report a case of a kidney transplant recipient with recurrent HSPN that was successfully treated with steroid pulse therapy and epipharyngeal abrasive therapy (EAT). A 39-year-old Japanese man developed HSPN 4 years ago and had to start hemodialysis after 2 months despite receiving steroid pulse therapy followed by oral prednisolone, plasma exchange therapy, and cyclophosphamide pulse therapy. He had undergone tonsillectomy 3 years earlier in the hopes of achieving a better outcome of a planned kidney transplantation and received a living-donor kidney transplantation from his mother 1 year earlier. Although there were no abnormalities in the renal function or urinalysis 2 months after transplantation, a routine kidney allograft biopsy revealed evidence of mesangial proliferation and cellular crescent formation. Mesangial deposition for IgA and C3 was noted, and he was diagnosed with recurrent HSPN histologically. Since the renal function and urinalysis findings deteriorated 5 months after transplantation, 2 courses of steroid pulse therapy were performed but were ineffective. EAT using 0.5% zinc chloride solution once per day was combined with the third course of steroid pulse therapy, as there were signs of chronic epipharyngitis. His renal function recovered 3 months after daily EAT and has been stable for 1.5 years since transplantation. Daily EAT continued for >3 months might be a suitable strategy for treating recurrent HSPN in cases of kidney transplantation.

Published
2021
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25. The effect of an L/N-type calcium channel blocker on intradialytic blood pressure in intradialytic hypertensive patients.

Author

Ito, Takayasu, Fujimoto, Naoki, Ishikawa, Eiji, Dohi, Kaoru, Fujimoto, Mika, Murata, Tomohiro, Kiyohara, Michiyo, Takeuchi, Hideyuki, Koyabu, Sukenari, Nishimura, Hiroyuki, Takeuchi, Toshiaki, and Ito, Masaaki

Subjects
CALCIUM antagonists, BLOOD pressure, SYSTOLIC blood pressure
Abstract

Background: Intradialytic hypertension (HTN), which is one of the poor prognostic markers in patients undergoing hemodialysis, may be associated with sympathetic overactivity. The L/N-type calcium channel blocker, cilnidipine, has been reported to suppress sympathetic nerves activity in vivo. Therefore, we hypothesized that cilnidipine could attenuate intradialytic systolic blood pressure (SBP) elevation. Methods: Fifty-one patients on chronic hemodialysis who had intradialytic-HTN (SBP elevation ≥10 mmHg during hemodialysis) and no fluid overload were prospectively randomized into two groups: control and cilnidipine groups. Cilnidipine group patients took cilnidipine (10 mg/day) for 12 weeks. The primary endpoint was the change in the intradialytic SBP elevation before and after the 12-week intervention. Results: Before the intervention, no differences were observed in age, sex or pre-dialytic SBP (148.5 ± 12.9 vs. 148.3 ± 19.3 mmHg) between the two groups. Intradialytic SBP elevation was unchanged in the control group. Cilnidipine significantly lowered the post-dialytic SBP with an attenuation of the intradialytic SBP elevation from 12.0 ± 15.4 mmHg to 4.8 ± 10.1 mmHg. However, the observed difference in the intradialytic SBP elevation by cilnidipine did not reach statistical significance (group×time interaction effect p = 0.25). Cathecolamine levels were unaffected by the intervention in both groups. Conclusion: Cilnidipine lowers both the pre- and post-dialytic SBP and might attenuate intradialytic SBP elevation. Therefore, cilnidipine may be effective in lowering SBP during HD in patients with intradialytic-HTN. [ABSTRACT FROM AUTHOR]

Published
2019
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28. Granulomatous interstitial nephritis due to chronic lymphocytic leukemia: a case report.

Author

Yasuo Suzuki, Kan Katayama, Eiji Ishikawa, Shoko Mizoguchi, Keiko Oda, Hirabayashi, Ayumi Haruki, Takayasu Ito, Mika Fujimoto, Tomohiro Murata, Masaaki Ito, Suzuki, Yasuo, Katayama, Kan, Ishikawa, Eiji, Mizoguchi, Shoko, Oda, Keiko, Hirabayashi, Yosuke, Haruki, Ayumi, Ito, Takayasu, and Fujimoto, Mika

Subjects
CHRONIC lymphocytic leukemia diagnosis, KIDNEY failure, INTERSTITIAL nephritis, RENAL biopsy, CHRONIC lymphocytic leukemia, DISEASE complications, DIAGNOSIS
Abstract

Background: Renal failure due to the infiltration of chronic lymphocytic leukemia (CLL) cells into the tubulointerstitial area of the kidney is uncommon. Furthermore, granulomatous interstitial nephritis (GIN) is a rare histological diagnosis in patients undergoing a renal biopsy. We herein report a case of GIN due to the diffuse infiltration of CLL cells in a patient who developed progressive renal failure.Case Presentation: The patient was a 55-year-old man who had been diagnosed with CLL 4 years earlier and who had been followed up without treatment. Although his serum creatinine level had remained normal for three and a half years, it started to increase in the six months prior to his presentation. A urinalysis showed mild proteinuria without any hematuria at the time of presentation. A renal biopsy revealed the diffuse infiltration of CLL cells into the tubulointerstitial area with non-caseating epithelioid cell granulomas. Despite cyclophosphamide treatment, his renal function did not improve, and he ultimately required maintenance hemodialysis.Conclusion: When progressive renal failure is combined with CLL, GIN due to the direct infiltration of CLL cells should be considered as a differential diagnosis. [ABSTRACT FROM AUTHOR]

Published
2017
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30. Tocilizumab for uncontrollable systemic inflammatory response syndrome complicating adult-onset Still disease: Case report and review of literature.

Author

Asami Masui-Ito, Ryuji Okamoto, Kaoru Ikejiri, Mika Fujimoto, Muneyoshi Tanimura, Shiro Nakamori, Tomohiro Murata, Eiji Ishikawa, Norikazu Yamada, Hiroshi Imai, Masaaki Ito, Masui-Ito, Asami, Okamoto, Ryuji, Ikejiri, Kaoru, Fujimoto, Mika, Tanimura, Muneyoshi, Nakamori, Shiro, Murata, Tomohiro, Ishikawa, Eiji, and Yamada, Norikazu

Published
2017
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32. Synthesis and Antibacterial Activity of a Novel Series of Potent DNA Gyrase Inhibitors. Pyrazole Derivatives

Author

Tanitame, Akihiko, primary, Oyamada, Yoshihiro, additional, Ofuji, Keiko, additional, Fujimoto, Mika, additional, Iwai, Noritaka, additional, Hiyama, Yoichi, additional, Suzuki, Kenji, additional, Ito, Hideaki, additional, Terauchi, Hideo, additional, Kawasaki, Motoji, additional, Nagai, Kazuo, additional, Wachi, Masaaki, additional, and Yamagishi, Jun-ichi, additional

Published
2004
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42. Nitrooxy alkyl apovincaminate modulates GABAAreceptor in rat neocortical neurones

Author

Munakata, Mitsutoshi, Fujimoto, Mika, Akaike, Norio, and Araki, Hiroaki

Abstract

We investigated the effects of VA-045 ((+)-eburnamenine-14 carboxylic acid (2-nitroxyethyl) ester) on GABAAreceptor-mediated Cl−currents in dissociated rat cerebral cortical neurones, using a nystatin-perforated patch recording configuration. At a holding potential of - 40 mV, the external application of GAB A evoked an inward Cl current with an EC50value of 5.6 ± 10−6M. VA-045 increased the GABA response at GABA concentrations below 3.0 ± 10−6M. The GABA response showed a time dependent decay consisting of fast and slow components and VA-045 significantly accelerated both components. The site of action for VA-045 was considered to be different from that for benzodiazepines or barbiturates.

Published
1996

43. Renal Medullary Angiitis Associated with Cutaneous Leukocytoclastic Vasculitis.

Author

Miura S, Katayama K, Joh K, Fujimoto M, Yamakawa M, Akiyama E, Nishida J, Yasutomi M, Ishikawa E, and Dohi K

Subjects
Humans, Male, Aged, 80 and over, Methylprednisolone therapeutic use, Kidney Medulla pathology, Plasma Exchange, Prednisolone therapeutic use, Vasculitis diagnosis, Vasculitis complications, Vasculitis, Leukocytoclastic, Cutaneous diagnosis, Vasculitis, Leukocytoclastic, Cutaneous complications, Vasculitis, Leukocytoclastic, Cutaneous pathology
Abstract

Renal medullary angiitis is characterized by interstitial hemorrhaging in the medulla with neutrophil infiltration. An 81-year-old man presented with a fever, kidney dysfunction, and purpura of the legs, which was diagnosed as leukocytoclastic vasculitis. Proteinase 3 antineutrophil cytoplasmic antibodies were weakly positive. A kidney biopsy showed severe tubulointerstitial hemorrhaging with neutrophilic infiltration in the perivascular areas surrounding the vasa recta in the medulla without crescent formation in the glomeruli. An immunofluorescence analysis was negative, and electron microscopy revealed no immune-dense deposits, ruling out immunoglobulin A vasculitis. Intravenous methylprednisolone for three days and plasma exchange followed by oral prednisolone improved his general condition.

Published
2024
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