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28 results on '"Fujii, Keitaro"'

5. CD271 mRNA/hnRNPA2B1 complex promotes proliferation and stemness in oral and head and neck squamous cell carcinoma.

Author

Mochizuki, Mai, Shibuya‐Takahashi, Rie, Kanno, Shin‐Ichiro, Adachi, Shungo, Fujimori, Haruna, Nakazato, Akira, Fujii, Keitaro, Morita, Shinkichi, Saijoh, Satoshi, Yamazaki, Tomoko, Imai, Takayuki, Asada, Yukinori, Yamaguchi, Kazunori, Yasuda, Jun, Shindo, Norihisa, Sugamura, Kazuo, and Tamai, Keiichi

Abstract

RNAs, such as noncoding RNA, microRNA, and recently mRNA, have been recognized as signal transduction molecules. CD271, also known as nerve growth factor receptor, has a critical role in cancer, although the precise mechanism is still unclear. Here, we show that CD271 mRNA, but not CD271 protein, facilitates spheroid cell proliferation. We established CD271−/− cells lacking both mRNA and protein of CD271, as well as CD271 protein knockout cells lacking only CD271 protein, from hypopharyngeal and oral squamous cell carcinoma lines. Sphere formation was reduced in CD271−/− cells but not in CD271 protein knockout cells. Mutated CD271 mRNA, which is not translated to a protein, promoted sphere formation. CD271 mRNA bound to hnRNPA2B1 protein at the 3′‐UTR region, and the inhibition of this interaction reduced sphere formation. In surgical specimens, the CD271 mRNA/protein expression ratio was higher in the cancerous area than in the noncancerous area. These data suggest CD271 mRNA has dual functions, encompassing protein‐coding and noncoding roles, with its noncoding RNA function being predominant in oral and head and neck squamous cell carcinoma. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Enhanced recovery after surgery program involving preoperative dexamethasone administration for head and neck surgery with free tissue transfer reconstruction: Single-center prospective observational study

Author

Imai, Takayuki, Kurosawa, Koreyuki, Asada, Yukinori, Momma, Yumiko, Takahashi, Maki, Satake, Naoko, Azuma, Misato, Suzuki, Ai, Sasaki, Megumi, Morita, Sinkichi, Saijo, Satoshi, Fujii, Keitaro, Kishimoto, Kazuhiro, Yamazaki, Tomoko, Goto, Takahiro, and Matsuura, Kazuto

Published
2020
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12. Establishment of a monoclonal antibody against glycosylated CD271 specific for cancer cells in immunohistochemistry

Author

Fujii, Keitaro, primary, Morita, Shinkichi, additional, Mochizuki, Mai, additional, Shibuya‐Takahashi, Rie, additional, Fujimori, Haruna, additional, Yamaguchi, Kazunori, additional, Abe, Jiro, additional, Yamazaki, Tomoko, additional, Imai, Takayuki, additional, Sugamura, Kazuo, additional, Yasuda, Jun, additional, Satoh, Kennichi, additional, Sato, Ikuro, additional, Saito‐Koyama, Ryoko, additional, Fujishima, Fumiyoshi, additional, Sasano, Hironobu, additional, Kato, Yukinari, additional, Matsuura, Kazuto, additional, Asada, Yukinori, additional, and Tamai, Keiichi, additional

Published
2022
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13. Cover

Author

Ito, Shin, primary, Hashimoto, Aya, additional, Yamaguchi, Kazunori, additional, Kawamura, Sadafumi, additional, Myoen, Shingo, additional, Ogawa, Maki, additional, Sato, Ikuro, additional, Minato, Takamichi, additional, Miyabe, Shingo, additional, Nakazato, Akira, additional, Fujii, Keitaro, additional, Mochizuki, Mai, additional, Fujimori, Haruna, additional, Tamai, Keiichi, additional, Niihori, Tetsuya, additional, Aoki, Yoko, additional, Sugawara, Akira, additional, Sasano, Hironobu, additional, Shima, Hiroshi, additional, and Yasuda, Jun, additional

Published
2022
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14. A novel 8.57‐kb deletion of the upstream region of PRKAR1A in a family with Carney complex

Author

Ito, Shin, primary, Hashimoto, Aya, additional, Yamaguchi, Kazunori, additional, Kawamura, Sadafumi, additional, Myoen, Shingo, additional, Ogawa, Maki, additional, Sato, Ikuro, additional, Minato, Takamichi, additional, Miyabe, Shingo, additional, Nakazato, Akira, additional, Fujii, Keitaro, additional, Mochizuki, Mai, additional, Fujimori, Haruna, additional, Tamai, Keiichi, additional, Niihori, Tetsuya, additional, Aoki, Yoko, additional, Sugawara, Akira, additional, Sasano, Hironobu, additional, Shima, Hiroshi, additional, and Yasuda, Jun, additional

Published
2022
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22. Performance and durability of carbon black-supported Pd catalyst covered with silica layers in membrane-electrode assemblies of proton exchange membrane fuel cells

Author

Sakae Takenaka, Mizuki Ito, Masahiro Kishida, Yasushi Sato, and Fujii Keitaro

Subjects
Materials science, Renewable Energy, Sustainability and the Environment, Energy Engineering and Power Technology, Proton exchange membrane fuel cell, chemistry.chemical_element, Nanotechnology, Carbon black, Cathode, Catalysis, law.invention, Membrane, Chemical engineering, chemistry, law, Electrode, Electrical and Electronic Engineering, Physical and Theoretical Chemistry, Rotating disk electrode, Palladium
Abstract

Pd metal particles supported on a high surface area carbon black (Pd/CB) were covered with silica layers to improve the durability under severe cathode condition of proton exchange membrane fuel cells (PEMFCs). The performance and the durability of the silica-coated Pd/CB (SiO2/Pd/CB) were investigated by rotating disk electrode (RDE) in aqueous HClO4 and single cell test of the membrane-electrode assemblies (MEAs). SiO2/Pd/CB showed excellent durability exceeding Pt/CB during potential cycle in single cell test as well as in RDE measurement while Pd/CB significantly degraded. Furthermore, the MEA using SiO2/Pd/CB as the cathode catalyst showed higher performance than that using Pd/CB even in the initial state. The catalytic activity of SiO2/Pd/CB was higher than that of Pd/CB, and the drop of the cell performances due to the inhibition of electron conduction, proton conduction, and oxygen diffusion by the silica layer was not significant. It has been shown that the silica-coating is a very practical technique that can stabilize metal species originally unstable in the cathode condition of PEMFCs without a decrease in the cell performance.

Published
2015

24. Enhanced Recovery After Surgery program with dexamethasone administration for major head and neck surgery with free tissue transfer reconstruction: initial institutional experience

Author

Imai, Takayuki, primary, Kurosawa, Koreyuki, additional, Yamaguchi, Kayo, additional, Satake, Naoko, additional, Asada, Yukinori, additional, Matsumoto, Ko, additional, Morita, Sinkichi, additional, Saijo, Satoshi, additional, Aoi, Jiro, additional, Fujii, Keitaro, additional, Kishimoto, Kazuhiro, additional, Goto, Takahiro, additional, and Matsuura, Kazuto, additional

Published
2018
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28. Effects of Oxygen Vacancies and Reaction Conditions on Oxygen Reduction Reaction on Pyrochlore-Type Lead-Ruthenium Oxide

Author

Fujii, Keitaro, Sato, Yasushi, Takase, Satoko, and Shimizu, Youichi

Abstract

A series of pyrochlore-type lead-ruthenium oxide (Pb2Ru2O7-d) containing various amounts of oxygen vacancies was prepared by varying the heat-treatment temperature, and the oxygen reduction reaction (ORR) activity as well as the electrochemical redox property in acid and alkaline solution was evaluated using rotating disk electrode. The specific ORR activity was increased with increasing the amount of oxygen vacancies, and linearly correlated to the charge amount of electrochemical redox of Pb2Ru2O7-d both in acid and alkaline solution. We concluded that the surface oxygen vacancy participates in the electrochemical redox of Pb2Ru2O7-d, and at the same time, behaves as the active site for ORR. The ORR activity in alkaline solution was much higher than that in acid solution, possibly because of the difference of the facility of electrochemical desorption of adsorbed oxygen species in the ORR process. Additionally, the effect of humidity on the ORR activity was investigated by single cell test. It was revealed that Pb2Ru2O7-d shows absolutely high ORR activity in dry condition.

Published
2015

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