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1,027 results on '"Fujii, Hirofumi"'

3. Investigation of the Status of Unit 2 Nuclear Reactor of the Fukushima Daiichi by the Cosmic Muon Radiography

Author

Fujii, Hirofumi, Hara, Kazuhiko, Hashimoto, Shugo, Hayashi, Kohei, Kakuno, Hidekazu, Kodama, Hideyo, Meiki, Gi, Mizokami, Masato, Mizokami, Shinya, Nagamine, Kanetada, Sato, Kotaro, Sekita, Shunsuke, Shirai, Hiroshi, Kim, Shin-Hong, Sumiyoshi, Takayuki, Suzuki, Atsuto, Takada, Yoshihisa, Takahashi, Kazuki, Takahashi, Yu, Takasaki, Fumihiko, Yamada, Daichi, and Yamashita, Satoru

Subjects
Physics - Instrumentation and Detectors
Abstract

We have investigated the status of the nuclear debris in the Unit-2 Nuclear Reactor of the Fukushima Daiichi Nuclear Power plant by the method called Cosmic Muon Radiography. In this measurement, the muon detector was placed outside of the reactor building as was the case of the measurement for the Unit-1 Reactor. Compared to the previous measurements, the detector was down-sized, which made us possible to locate it closer to the reactor and to investigate especially the lower part of the fuel loading zone. We identified the inner structures of the reactor such as the containment vessel, pressure vessel and other objects through the thick concrete wall of the reactor building. Furthermore, the observation showed existence of heavy material at the bottom of the pressure vessel, which can be interpreted as the debris of melted nuclear fuel dropped from the loading zone., Comment: 11 figures and 2 tables

Published
2020

4. Investigation of Unit-1 Nuclear Reactor of the Fukushima Daiichi by Cosmic Muon Radiography

Author

Fujii, Hirofumi, Hara, Kazuhiko, Hayashi, Kohei, Kakuno, Hidekazu, Kodama, Hideyo, Nagamine, Kanetada, Sato, Kotaro, Kim, Shin-Hong, Suzuki, Atsuto, Sumiyoshi, Takayuki, Takahashi, Kazuki, Takasaki, Fumihiko, Tanaka, Shuji, and Yamashita, Satoru

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

We have investigated the status of the nuclear fuel assemblies in Unit-1 reactor of the Fukushima Daiichi Nuclear Power plant by the method called Cosmic Muon Radiography. In this study, muon tracking detectors were placed outside of the reactor building. We succeeded in identifying the inner structure of the reactor complex such as the reactor containment vessel, pressure vessel, and other structures of the reactor building, through the concrete wall of the reactor building. We found that a large amount of fuel assemblies was missing in the original fuel loading zone inside the pressure vessel. It can be naturally interpreted that most of the nuclear fuel was melt and dropped down to the bottom of the pressure vessel or even below., Comment: 14 pages, 17 figures

Published
2020

6. Precise characterization of a corridor-shaped structure in Khufu’s Pyramid by observation of cosmic-ray muons

Author

Procureur, Sébastien, Morishima, Kunihiro, Kuno, Mitsuaki, Manabe, Yuta, Kitagawa, Nobuko, Nishio, Akira, Gomez, Hector, Attié, David, Sakakibara, Ami, Hikata, Kotaro, Moto, Masaki, Mandjavidze, Irakli, Magnier, Patrick, Lehuraux, Marion, Benoit, Théophile, Calvet, Denis, Coppolani, Xavier, Kebbiri, Mariam, Mas, Philippe, Helal, Hany, Tayoubi, Mehdi, Marini, Benoit, Serikoff, Nicolas, Anwar, Hamada, Steiger, Vincent, Takasaki, Fumihiko, Fujii, Hirofumi, Satoh, Kotaro, Kodama, Hideyo, Hayashi, Kohei, Gable, Pierre, Guerriero, Emmanuel, Mouret, Jean-Baptiste, Elnady, Tamer, Elshayeb, Yasser, and Elkarmoty, Mohamed

Published
2023
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8. Imaging the Inner Structure of a Nuclear Reactor by Cosmic Muon Radiography

Author

Fujii, Hirofumi, Hara, Kazuhiko, Hashimoto, Shogo, Hayashi, Kohei, Ito, Fumiaki, Kakuno, Hidekazu, Kodama, Hideyo, Nagamine, Kanetada, Sato, Kazuyuki, Satoh, Kotaro, Kim, Shin-Hong, Suzuki, Atsuto, Sumiyoshi, Takayuki, Takahashi, Kazuki, Takahashi, Yu, Takasaki, Fumihiko, Tanaka, Shuji, and Yamashita, Satoru

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

We studied the inner structure of the nuclear reactor of the Japan Atomic Power Company (JAPC) at Tokai, Japan, by the muon radiography. In this study, muon detectors were placed outside of the reactor building. By detecting cosmic muons penetrating through the wall of the reactor building, we could successfully identify the objects such as the containment vessel, pressure vessel, and other structures of the reactor. We also observed a concentration of heavy material which can be attributed to the nuclear fuel assemblies stored in the nuclear fuel storage pool., Comment: 15 pages, 22 figures, accepted for publication in PTEP

Published
2019

13. Simultaneous visualization of multiple radionuclides in vivo

Author

Yagishita, Atsushi, Takeda, Shin’ichiro, Katsuragawa, Miho, Kawamura, Tenyo, Matsumura, Hideaki, Orita, Tadashi, Umeda, Izumi O., Yabu, Goro, Caradonna, Pietro, Takahashi, Tadayuki, Watanabe, Shin, Kanayama, Yousuke, Mizuma, Hiroshi, Ohnuki, Kazunobu, and Fujii, Hirofumi

Published
2022
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14. Discovery of a big void in Khufu's Pyramid by observation of cosmic-ray muons

Author

Morishima, Kunihiro, Kuno, Mitsuaki, Nishio, Akira, Kitagawa, Nobuko, Manabe, Yuta, Moto, Masaki, Takasaki, Fumihiko, Fujii, Hirofumi, Satoh, Kotaro, Kodama, Hideyo, Hayashi, Kohei, Odaka, Shigeru, Procureur, Sébastien, Attié, David, Bouteille, Simon, Calvet, Denis, Filosa, Christopher, Magnier, Patrick, Mandjavidze, Irakli, Riallot, Marc, Marini, Benoit, Gable, Pierre, Date, Yoshikatsu, Sugiura, Makiko, Elshayeb, Yasser, Elnady, Tamer, Ezzy, Mustapha, Guerriero, Emmanuel, Steiger, Vincent, Serikoff, Nicolas, Mouret, Jean-Baptiste, Charlès, Bernard, Helal, Hany, and Tayoubi, Mehdi

Subjects
Physics - Instrumentation and Detectors
Abstract

The Great Pyramid or Khufu's Pyramid was built on the Giza Plateau (Egypt) during the IVth dynasty by the pharaoh Khufu (Cheops), who reigned from 2509 to 2483 BC. Despite being one of the oldest and largest monuments on Earth, there is no consensus about how it was built. To better understand its internal structure, we imaged the pyramid using muons, which are by-products of cosmic rays that are only partially absorbed by stone. The resulting cosmic-ray muon radiography allows us to visualize the known and potentially unknown voids in the pyramid in a non-invasive way. Here we report the discovery of a large void (with a cross section similar to the Grand Gallery and a length of 30 m minimum) above the Grand Gallery, which constitutes the first major inner structure found in the Great Pyramid since the 19th century. This void, named ScanPyramids Big Void, was first observed with nuclear emulsion films installed in the Queen's chamber (University of Nagoya), then confirmed with scintillator hodoscopes set up in the same chamber (KEK) and re-confirmed with gas detectors outside of the pyramid (CEA). This large void has therefore been detected with a high confidence by three different muon detection technologies and three independent analyses. These results constitute a breakthrough for the understanding of Khufu's Pyramid and its internal structure. While there is currently no information about the role of this void, these findings show how modern particle physics can shed new light on the world's archaeological heritage., Comment: Nature (2017)

Published
2017
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17. αvβ3 integrin-targeted magnetic resonance imaging in a pancreatic cancer mouse model using RGD-modified liposomes encapsulated with Fe-deferoxamine.

Author

Yoshimoto, Mitsuyoshi, Hayakawa, Takuya, Yamaguchi, Masayuki, Kimura, Sadaaki, and Fujii, Hirofumi

Subjects
MAGNETIC resonance imaging, DRUG delivery systems, LIPOSOMES, PANCREATIC cancer, MAGNETIC resonance
Abstract

Magnetic resonance (MR) imaging is a powerful imaging modality for obtaining anatomical information with high spatial and temporal resolution. In the drug delivery system (DDS) framework, nanoparticles such as liposomes are potential candidates for MR imaging. We validated that RGD peptides are possible targeting molecules for pancreatic cancer with αvβ3 integrin expression. This study aimed to evaluate RGD-modified liposomes loaded with ferrioxamine B for pancreatic cancer imaging. We synthesized four types of RGD-modified liposomes encapsulated with ferrioxamine B (SH-, H-, M-, and L-RGD-liposomes). The binding affinity of RGD-modified liposomes was evaluated in a competitive inhibition study using 125I-echistatin. To investigate the pharmacokinetics of RGD-modified liposomes, a biodistribution study using RGD-liposomes labeled with 111In was carried out in a human pancreatic cancer PANC-1 xenograft mouse model. Finally, MR was performed using ferrioxamine-B-loaded liposomes. RGD-liposomes inhibited the binding of 125I-echistatin to RGD. The biodistribution study revealed that 111In-RGD-liposomes accumulated significantly in the liver and spleen. Among the 111In-RGD-liposomes, 111In-H-RGD-liposomes showed the highest tumor-to-normal tissue ratio. In the MR study, H-RGD-liposomes loaded with ferrioxamine B showed higher tumor-to-muscle signal ratios than RKG-liposomes loaded with ferrioxamine B (control). We successfully synthesized RGD-liposomes that can target αvβ3 integrin. [ABSTRACT FROM AUTHOR]

Published
2024
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18. CdTe XG‐Cam: A new high‐resolution x‐ray and gamma‐ray camera for studies of the pharmacokinetics of radiopharmaceuticals in small animals.

Author

Katsuragawa, Miho, Yagishita, Atsushi, Takeda, Shin'ichiro, Minami, Takahiro, Ohnuki, Kazunobu, Fujii, Hirofumi, and Takahashi, Tadayuki

Subjects
SEMICONDUCTOR detectors, CADMIUM telluride, 3-D printers, COLLIMATORS, PHARMACOKINETICS, NUCLIDES
Abstract

Background: The recent emergence of targeted radionuclide therapy has increased the demand for imagers capable of visualizing pharmacokinetics in developing radiopharmaceuticals in the preclinical phase. Some radionuclides emit hard x‐rays and gamma‐rays below 100 keV, in which energy range the performance of conventional NaI scintillators is poor. Multipinhole collimators are also used for small animal imaging with a good spatial resolution but have a limited field of view (FOV). Purpose: In this study, a new imager with high sensitivity over a wide FOV in the low‐energy band (<$<$100 keV) was developed for the pharmacokinetic study. Methods: We developed an x‐ray and gamma‐ray camera for high‐resolution spectroscopy, named "CdTe XG‐Cam," equipped with a cadmium telluride semiconductor detector and a parallel‐hole collimator using a metal 3D printer. To evaluate the camera‐system performance, phantom measurements with single and dual nuclides (99mTc$^{\rm 99m}{\rm Tc}$, 111In$^{111}{\rm In}$, and 125I)$^{125}{\rm I)}$ were performed. The performance for in vivo imaging was evaluated using tumor‐bearing mice to which a nuclide (99mTc$^{\rm 99m}{\rm Tc}$ or 125I)$^{125}{\rm I)}$ administered. Results: We simultaneously obtained information on 111In$^{111}{\rm In}$ and 125I$^{125}{\rm I}$, which emit emission lines in the low‐energy band with peak energies close to each other (23–26 keV for 111In$^{111}{\rm In}$ and 27–31 keV for 125I)$^{125}{\rm I)}$, and applied an analytical method based on spectral model fitting to determine the individual radioactivities accurately. In the small animal imaging, the distributions of the nuclide in tumors were accurately quantified and time‐activity curves in tumors are obtained. Conclusions: The demonstrated capability of our system to perform in vivo imaging suggests that the camera can be used for applications of pharmacokinetics research. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Randomised phase II study of panitumumab plus irinotecan versus cetuximab plus irinotecan in patients with KRAS wild-type metastatic colorectal cancer refractory to fluoropyrimidine, irinotecan and oxaliplatin (WJOG 6510G)

Author

Sakai, Daisuke, Taniguchi, Hiroya, Sugimoto, Naotoshi, Tamura, Takao, Nishina, Tomohiro, Hara, Hiroki, Esaki, Taito, Denda, Tadamichi, Sakamoto, Takeshi, Okuda, Hiroyuki, Satoh, Taroh, Tsushima, Takahiro, Makiyama, Akitaka, Tsuda, Takashi, Hosokawa, Ayumu, Kuramochi, Hidekazu, Tokunaga, Shinya, Moriwaki, Toshikazu, Yasui, Hisateru, Ishida, Hiroyasu, Tsuji, Akihito, Otsu, Satoshi, Shimokawa, Hozumi, Baba, Eishi, Sato, Mikio, Matsumoto, Shigemi, Ozaki, Yukinori, Shinozaki, Katsunori, Tamagawa, Hiroshi, Goto, Masahiro, Kadowaki, Shigenori, Fujii, Hirofumi, Koh, Yasuhiro, Yamazaki, Kentaro, Hironaka, Shuichi, Kishimoto, Junji, Boku, Narikazu, Hyodo, Ichinosuke, and Muro, Kei

Published
2020
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21. Pertuzumab, trastuzumab, and docetaxel for HER2-positive metastatic breast cancer (CLEOPATRA): end-of-study results from a double-blind, randomised, placebo-controlled, phase 3 study

Author

Agajanian, Richy, Ahmad, Rizvana, Aktas, Bahriye, Alencar, Victor Hugo, Amadori, Dino, Andrade, Jurandyr, André Franke, Fábio, Angiolini, Catia, Aogi, Kenjiro, Armor, Jess, Arpornwirat, Wichit, Assersohn, Laura, Audeh, William, Aulitzky, Walter, Azevedo, Sergio, Bartoli, Maria Alejandra, Batista Lopez, Norberto, Bianconi, María, Biganzoli, Laura, Birhiray, Ruemu, Bitina, Marianna, Blachy, Ron, Blackwell, Kimberly, Blanchard, Rita, Blanchet, Paulette, Boiangiu, Ion, Bower, Barbara, Brezden-Masley, Christine, Brufsky, Adam, Budde, Leanne, Caguioa, Priscilla, Calvo, Lourdes, Campone, Mario, Carroll, Robert R., Castro, Hugo, Chan, Valorie, Charu, Veena, Cinieri, Saverio, Clemens, Michael, Conejo, Emilio Alba, Côrtes, Eduardo, Coudert, Bruno, Cronemberger, Eduardo, Cubero, Daniel, Dakhil, Shaker, Daniel, Brooke, Davidson, Neville, De Fatima Gaui, Maria, De La Cruz, Susana, Del Pilar, Maria, Delgado, Gilson, Ellerton, John A., Estuardo, Cesar, Fehrenbacher, Louis, Ferrero, Jean-Marc, Flynn, Patrick J., Foszczynska-Kloda, Malgorzata, Franco, Sandra, Fujii, Hirofumi, Gallagher, Chris, Gamucci, Teresa, Giacomi, Nora, Gil I Gil, Miguel, Gonzalez Martin, Antonio, Gorbunova, Vera, Gotovkin, Eugeny, Green, Nathan, Grincuka, Elza, Grischke, Eva-Maria, Hansen, Vincent, Hargis, Jeffrey, Hauschild, Maik, Hegg, Roberto, Hendricks, Carolyn, Hermann, Robert, Hoff, Paulo, Horiguchi, Jun, Hornedo Muguiro, Javier, Iacobelli, Stefano, Inoue, Kenichi, Ismael, Gustavo, Itoh, Yoshinori, Iwata, Dr Hiroji, Jendiroba, Davi, Jochim, Rosa, Jones, Alison, Just, Marianne, Kallab, Andre, Karwal, Mark, Kashiwaba, Masahiro, Kato, Giraldo, Kaufman, Peter A., Kellokumpu-Lehtinen, Pirkko, Kirsch, Andreas, Kiselev, Igor, Klein, Paula, Kohno, Norio, Kopp, Mikhail, Kostovska-Maneva, Liljana, Kotliar, Mauricio, Kudaba, Iveta, Kümmel, Sherko, Kuroi, Katsumasa, Lacava, Juan, Latini, Luciano, Lee, Soo Chin, Lichinitser, Mikhail, Lobo, Christopher, Maintz, Christoph, Maneecahvakajorn, Jedzada, Marmé, Alexander, Martinez, Gloria, Masuda, Norikazu, Matwiejuk, Mario, Merculov, Vladimir, Michaelson, Richard, Miguel, Luis, Monroy, Hernandez, Montemurro, Filippo, Morales, Serafin, Moura, Rodrigo, Mueller, Volkmar, Mulatero, Clive, Nakagami, Kazuhiko, Nakayama, Takahiro, Neidhart, Jeff, Nguyen, An, Nishimura, Reiki, Ogata, Haruki, O'reilly, Susan, O'rourke, Timothy, Otero Reye, Douglas, Ouyang, Xuenong, Patel, Ravi, Patel, Taral, Pedrini, Jose Luiz, Pereira, Rodrigo, Perez, Alejandra, Peterson, Carol, Pienkowski, Tadeusz, Pinczowski, Helio, Polikoff, Jonathan, Polkowski, Wojciech, Price, Paola Edith, Prill, Sue, Priou, Frank, Purkalne, Gunta, Pyrhoenen, Seppo, Quackenbush, Robert, Rai, Yoshiaki, Ribelles, Nuria, Ro, Jungsil, Robinson, Anne, Robles, Robert, Rodriguez, Gladys, Roman, Laslo, Saji, Shigehira, Sanchez-Rovira, Pedro, Sato, Nobuaki, Schmidt, Marcus, Schumacher, Claudia, Senecal, Frank, Sharma, Priyanka, Shen, Zhenzhou, Shirinkin, Vadim, Simoncini, Edda, Sirisinha, Thitiya, Smith, Raymond, Sohn, Joo-Hyuk, Soldic, Zeljko, Soria, Tania, Spicer, Darcy, Srimuninnimit, Vichien, Sriuranpong, Virote, Staroslawska, Elzbieta, Stefanovski, Petar, Sunpaweravong, Patrapim, Taguchi, Julie, Takeda, Koji, Tellez-Trevilla, Gabriel, Thomas, Randall, Thomssen, Christoph, Toache, Zetina, Tokuda, Yutaka, Tomczak, Piotr, Tosello, Celia, Tsugawa, Koichiro, Tudtud, Dennis, Ueno, Takayuki, Van Eyll, Brigitte, Varela, Mirta, Vasev, Nikola, Vrbanec, Damir, Wang, Xiaojia, Wang, Liwei, Watanabe, Junichiro, Waterhouse, David, Wesenberg, Birgitta, Wheatley, Duncan, Wong, Zee Wan, Yadav, Sanjay, Yardley, Denise, Yau, Tsz-Kok, Yeo, Winnie, Ying, Cheng, Youn Oh, Do, Swain, Sandra M, Miles, David, Kim, Sung-Bae, Im, Young-Hyuck, Im, Seock-Ah, Semiglazov, Vladimir, Ciruelos, Eva, Schneeweiss, Andreas, Loi, Sherene, Monturus, Estefanía, Clark, Emma, Knott, Adam, Restuccia, Eleonora, Benyunes, Mark C, and Cortés, Javier

Published
2020
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22. Supplemental Table S1 from Amelioration of Tumor-promoting Microenvironment via Vascular Remodeling and CAF Suppression Using E7130: Biomarker Analysis by Multimodal Imaging Modalities

Author

Ito, Ken, primary, Yamaguchi, Masayuki, primary, Semba, Taro, primary, Tabata, Kimiyo, primary, Tamura, Moe, primary, Aoyama, Muneo, primary, Abe, Takanori, primary, Asano, Osamu, primary, Terada, Yasuhiko, primary, Funahashi, Yasuhiro, primary, and Fujii, Hirofumi, primary

Published
2024
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23. Supplementary Fig. S9 from Amelioration of Tumor-promoting Microenvironment via Vascular Remodeling and CAF Suppression Using E7130: Biomarker Analysis by Multimodal Imaging Modalities

Author

Ito, Ken, primary, Yamaguchi, Masayuki, primary, Semba, Taro, primary, Tabata, Kimiyo, primary, Tamura, Moe, primary, Aoyama, Muneo, primary, Abe, Takanori, primary, Asano, Osamu, primary, Terada, Yasuhiko, primary, Funahashi, Yasuhiro, primary, and Fujii, Hirofumi, primary

Published
2024
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25. Equivalent prognosis with no lymph node metastasis to pathological complete remission in patients with localized advanced esophageal cancer after neoadjuvant triplet chemotherapy with docetaxel, cisplatin, and 5-fluorouracil followed by curative surgery: a single-center retrospective cohort study

Author

Chinen, Takashi, primary, Yamaguchi, Hironori, additional, Ohzawa, Hideyuki, additional, Matsumoto, Shiro, additional, Kurashina, Kentaro, additional, Saito, Shin, additional, Hosoya, Yoshinori, additional, Fujii, Hirofumi, additional, Kitayama, Joji, additional, and Sata, Naohiro, additional

Published
2024
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27. Optimizing antiemetic treatment for chemotherapy-induced nausea and vomiting in Japan: Update summary of the 2015  Japan Society of Clinical Oncology Clinical Practice Guidelines for Antiemesis

Author

Aogi, Kenjiro, Takeuchi, Hideki, Saeki, Toshiaki, Aiba, Keisuke, Tamura, Kazuo, Iino, Keiko, Imamura, Chiyo K., Okita, Kenji, Kagami, Yoshikazu, Tanaka, Ryuhei, Nakagawa, Kazuhiko, Fujii, Hirofumi, Boku, Narikazu, Wada, Makoto, Akechi, Tatsuo, Iihara, Hirotoshi, Ohtani, Shoichiro, Okuyama, Ayako, Ozawa, Keiko, Kim, Yong-Il, Sasaki, Hidenori, Shima, Yasuo, Takeda, Masayuki, Nagasaki, Eijiro, Nishidate, Toshihiko, Higashi, Takahiro, and Hirata, Kouichi

Published
2021
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29. Ramucirumab after prior sorafenib in patients with advanced hepatocellular carcinoma and elevated alpha-fetoprotein: Japanese subgroup analysis of the REACH-2 trial

Author

Kudo, Masatoshi, Okusaka, Takuji, Motomura, Kenta, Ohno, Izumi, Morimoto, Manabu, Seo, Satoru, Wada, Yoshiyuki, Sato, Shinpei, Yamashita, Tatsuya, Furukawa, Masayuki, Aramaki, Takeshi, Nadano, Seijin, Ohkawa, Kazuyoshi, Fujii, Hirofumi, Kudo, Toshihiro, Furuse, Junji, Takai, Hiroki, Homma, Gosuke, Yoshikawa, Reigetsu, and Zhu, Andrew X.

Published
2020
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33. CdTe-DSD SPECT-I: An Ultrahigh-Resolution Multi-Isotope Tomographic Imager for Mice

Author

Takeda, Shin’ichiro, primary, Orita, Tadashi, additional, Yagishita, Atsushi, additional, Katsuragawa, Miho, additional, Yabu, Goro, additional, Tomaru, Ryota, additional, Moriyama, Fumiki, additional, Sugawara, Hirotaka, additional, Watanabe, Shin, additional, Mizuma, Hiroshi, additional, Kanayama, Yousuke, additional, Ohnuki, Kazunobu, additional, Fujii, Hirofumi, additional, Furenlid, Lars R., additional, and Takahashi, Tadayuki, additional

Published
2023
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34. MO19-3 Subgroup analyses of phase II study of weekly paclitaxel in advanced esophageal cancer that had previously received docetaxel-containing chemotherapy

Author

Nakashima, Koji, primary, Ando, Takayuki, additional, Yoshida, Hiroki, additional, Sakumura, Miho, additional, Nomura, Motoo, additional, Muto, Manabu, additional, Fujii, Hirofumi, additional, Horie, Yoshiki, additional, Takeda, Hiroyuki, additional, Yoshii, Takako, additional, Tahara, Yoshihiro, additional, Katada, Chikatoshi, additional, Yoshimura, Kenichi, additional, Hideki, Ishikawa, additional, and Hosokawa, Ayumu, additional

Published
2023
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36. Amelioration of Tumor-Promoting Microenvironment via Vascular Remodeling and CAF Suppression using E7130: Biomarker Analysis by Multi-modal Imaging Modalities

Author

Ito, Ken, primary, Yamaguchi, Masayuki, additional, Semba, Taro, additional, Tabata, Kimiyo, additional, Tamura, Moe, additional, Aoyama, Muneo, additional, Abe, Takanori, additional, Asano, Osamu, additional, Terada, Yasuhiko, additional, Funahashi, Yasuhiro, additional, and Fujii, Hirofumi, additional

Published
2023
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38. Relationship Between Thymidine Kinase 1 Expression and Trifluridine/Tipiracil Therapy in Refractory Metastatic Colorectal Cancer: A Pooled Analysis of 2 Randomized Clinical Trials

Author

Yoshino, Takayuki, Yamazaki, Kentaro, Shinozaki, Eiji, Komatsu, Yoshito, Nishina, Tomohiro, Baba, Hideo, Tsuji, Akihito, Tsuji, Yasushi, Yamaguchi, Kensei, Sugimoto, Naotoshi, Denda, Tadamichi, Muro, Kei, Takayama, Tetsuji, Esaki, Taito, Hamamoto, Yasuo, Moriwaki, Toshikazu, Shimada, Yasuhiro, Goto, Masahiro, Nakayama, Norisuke, Fujii, Hirofumi, Tanase, Takanori, and Ohtsu, Atsushi

Published
2018
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40. A subanalysis of Japanese patients in a randomized, double-blind, placebo-controlled, phase 3 trial of nivolumab for patients with advanced gastric or gastro-esophageal junction cancer refractory to, or intolerant of, at least two previous chemotherapy regimens (ONO-4538-12, ATTRACTION-2)

Author

Kato, Ken, Satoh, Taroh, Muro, Kei, Yoshikawa, Takaki, Tamura, Takao, Hamamoto, Yasuo, Chin, Keisho, Minashi, Keiko, Tsuda, Masahiro, Yamaguchi, Kensei, Machida, Nozomu, Esaki, Taito, Goto, Masahiro, Komatsu, Yoshito, Nakajima, Takako Eguchi, Sugimoto, Naotoshi, Yoshida, Kazuhiro, Oki, Eiji, Nishina, Tomohiro, Tsuji, Akihito, Fujii, Hirofumi, Kunieda, Kenji, Saitoh, Soh, Omuro, Yasushi, Azuma, Mizutomo, Iwamoto, Yasuo, Taku, Keisei, Fushida, Sachio, Chen, Li-Tzong, Kang, Yoon-Koo, and Boku, Narikazu

Published
2019
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41. Early tumor shrinkage and depth of response in patients with advanced gastric cancer: a retrospective analysis of a randomized phase III study of first-line S-1 plus oxaliplatin vs. S-1 plus cisplatin

Author

Nishina, Tomohiro, Azuma, Mizutomo, Nishikawa, Kazuhiro, Gotoh, Masahiro, Bando, Hideaki, Sugimoto, Naotoshi, Amagai, Kenji, Chin, Keisho, Niwa, Yasumasa, Tsuji, Akihito, Imamura, Hiroshi, Tsuda, Masahiro, Yasui, Hirofumi, Fujii, Hirofumi, Yamaguchi, Kensei, Yasui, Hisateru, Hironaka, Shuichi, Shimada, Ken, Miwa, Hiroto, Mitome, Terukazu, Kageyama, Hiroki, and Hyodo, Ichinosuke

Published
2019
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42. Peritoneal metastasis as a predictive factor for nab-paclitaxel in patients with pretreated advanced gastric cancer: an exploratory analysis of the phase III ABSOLUTE trial

Author

Takashima, Atsuo, Shitara, Kohei, Fujitani, Kazumasa, Koeda, Keisuke, Hara, Hiroki, Nakayama, Norisuke, Hironaka, Shuichi, Nishikawa, Kazuhiro, Kimura, Yutaka, Amagai, Kenji, Fujii, Hirofumi, Muro, Kei, Esaki, Taito, Choda, Yasuhiro, Takano, Toshimi, Chin, Keisho, Sato, Atsushi, Goto, Masahiro, Fukushima, Norimasa, Hara, Takuo, Machida, Nozomu, Ohta, Manabu, Boku, Narikazu, Shimura, Masashi, Morita, Satoshi, and Koizumi, Wasaburo

Published
2019
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45. Supplementary Materials and Methods, Supplementary Figure Legends, and Supplementary Table Legends from The Use of Olaparib (AZD2281) Potentiates SN-38 Cytotoxicity in Colon Cancer Cells by Indirect Inhibition of Rad51-Mediated Repair of DNA Double-Strand Breaks

Author

Tahara, Makiko, primary, Inoue, Takeshi, primary, Sato, Futoshi, primary, Miyakura, Yasuyuki, primary, Horie, Hisanaga, primary, Yasuda, Yoshikazu, primary, Fujii, Hirofumi, primary, Kotake, Kenjiro, primary, and Sugano, Kokichi, primary

Published
2023
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