396 results on '"Fuerst, T"'
Search Results
2. Does standardized BMD still remove differences between Hologic and GE-Lunar state-of-the-art DXA systems?
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Fan, B, Lu, Y, Genant, H, Fuerst, T, and Shepherd, J
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Musculoskeletal ,Absorptiometry ,Photon ,Aged ,Aged ,80 and over ,Bone Density ,Female ,Femur Neck ,Hip Joint ,Humans ,Lumbar Vertebrae ,Middle Aged ,Reproducibility of Results ,Bone densitometry ,Standardization equation ,Standardized BMD ,Biomedical Engineering ,Clinical Sciences ,Public Health and Health Services ,Endocrinology & Metabolism - Abstract
UnlabelledThe standardized bone mineral density (sBMD) values, derived using universal standardized equations, were shown to be equivalent within 1.0% for hip but significantly different for spine for state-of-art fan-beam dual X-ray absorptiometry (DXA) Hologic and GE-Lunar systems. Spine L1-L4 and L2-L4 sBMD mean differences between the two systems were 0.042 g/cm(2) (4.1%) and 0.035 g/cm(2) (3.2%), respectively.IntroductionThe objective of this study is to validate the 1994 pencil-beam DXA "universal standardization equations" for state-of-the-art fan-beam DXA systems.MethodsThe spine and bilateral femurs of 87 postmenopausal women were scanned on both Hologic Delphi and GE-Lunar Prodigy DXA systems at three different clinical centers. The scans were analyzed using Hologic Apex and GE-Lunar EnCore software. The BMD results were converted to sBMD using the equations previously developed. Linear regression analysis was used to describe the relationship of the two systems' BMD results. Bland-Altman analysis was used to assess the differences in measures.ResultsThe Apex and Prodigy sBMD values were highly correlated (r ranged from 0.92 to 0.98). Spine L1-L4 and L2-L4 sBMD values had significant intercepts and slopes for Bland-Altman regression, with mean differences of 0.042 g/cm(2) (4.1%) and 0.035 g/cm(2) (3.2%), respectively. The total hip and neck sBMD showed no significant intercept and slope, except left total sBMD had a significant difference between the two systems of 0.009 g/cm(2) (1.0%).ConclusionsThe sBMD values were shown to be equivalent within 1.0% for hip but were significantly different for spine on the two systems. Biases may persist in pooled sBMD data from different manufacturers, and further study is necessary to determine the cause.
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- 2010
3. Automated quantitative morphometry of vertebral heights on spinal radiographs: comparison of a clinical workflow tool with standard 6-point morphometry
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Engelke, Klaus, Stampa, B., Steiger, P., Fuerst, T., and Genant, H. K.
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- 2019
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4. P123 Development of an end-to-end Mayo endoscopic score machine learning algorithm for use in clinical trials of ulcerative colitis
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Vieira, M, primary, Mishkin, D S, additional, Gaither, K W, additional, Safran, M, additional, Dashuta, A, additional, Tarakanov, A, additional, Zfira, L, additional, and Fuerst, T, additional
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- 2023
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5. Is drug-induced bone loss acceptable in premenopausal women? A practical fracture risk modeling exercise
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Binkley, N., Besuyen, R., Fuerst, T., Skillern, L., and Hans, D.
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- 2017
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6. Joint unloading implant modifies subchondral bone trabecular structure in medial knee osteoarthritis: 2-year outcomes of a pilot study using fractal signature analysis
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Miller LE, Sode M, Fuerst T, and Block JE
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disease modification ,fractal signature analysis ,implant ,KineSpring ,knee ,medial ,osteoarthritis ,subchondral ,Geriatrics ,RC952-954.6 - Abstract
Larry E Miller,1,2 Miki Sode,3 Thomas Fuerst,3 Jon E Block2 1Miller Scientific Consulting, Inc., Asheville, NC, USA; 2The Jon Block Group, San Francisco, CA, USA; 3Bioclinica, Newark, CA, USA Background: Knee osteoarthritis (OA) is largely attributable to chronic excessive and aberrant joint loading. The purpose of this pilot study was to quantify radiographic changes in subchondral bone after treatment with a minimally invasive joint unloading implant (KineSpring® Knee Implant System).Methods: Nine patients with unilateral medial knee OA resistant to nonsurgical therapy were treated with the KineSpring System and followed for 2 years. Main outcomes included Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain, function, and stiffness subscores and independent core laboratory determinations of joint space width and fractal signature of the tibial cortex.Results: WOMAC scores, on average, improved by 92% for pain, 91% for function, and 79% for stiffness over the 2-year follow-up period. Joint space width in the medial compartment of the treated knee significantly increased from 0.9 mm at baseline to 3.1 mm at 2 years; joint space width in the medial compartment of the untreated knee was unchanged. Fractal signatures of the vertically oriented trabeculae in the medial compartment decreased by 2.8% in the treated knee and increased by 2.1% in the untreated knee over 2 years. No statistically significant fractal signature changes were observed in the horizontally oriented trabeculae in the medial compartment or in the horizontal or vertical trabeculae of the lateral compartment in the treated knee.Conclusion: Preliminary evidence suggests that the KineSpring System may modify knee OA disease progression by increasing joint space width and improving subchondral bone trabecular integrity, thereby reducing pain and improving joint function. Keywords: disease modification, KineSpring, joint space, pain, trabecular
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- 2015
7. Highly Dynamic and Adaptive Traffic Congestion Avoidance in Real-Time Inspired by Honey Bee Behavior
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Wedde, Horst F., Lehnhoff, Sebastian, van Bonn, Bernhard, Bay, Z., Becker, S., Böttcher, S., Brunner, C., Büscher, A., Fürst, T., Lazarescu, A. M., Rotaru, E., Senge, S., Steinbach, B., Yilmaz, F., Zimmermann, T., Brauer, W., editor, Holleczek, Peter, editor, and Vogel-Heuser, Birgit, editor
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- 2008
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8. Quality Assurance in Bone Densitometry
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Fuerst, T., Lu, Y., Hans, D., Genant, H. K., Genant, Harry K., editor, Guglielmi, Giuseppe, editor, and Jergas, Michael, editor
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- 1998
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9. Quantitative Ultrasound for Assessing Bone Properties
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Hans, D., Fuerst, T., Guglielmi, G., Genant, H. K., Genant, Harry K., editor, Guglielmi, Giuseppe, editor, and Jergas, Michael, editor
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- 1998
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10. Comparison of Quantitative Computed Tomography and Dual X-Ray Absorptiometry at the Lumbar Spine in the Diagnosis of Osteoporosis
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Fuerst, T., Guglielmi, G., Cammisa, M., Genant, H. K., Genant, Harry K., editor, Guglielmi, Giuseppe, editor, and Jergas, Michael, editor
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- 1998
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11. Denosumab improves density and strength parameters as measured by QCT of the radius in postmenopausal women with low bone mineral density
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Genant, H.K., Engelke, K., Hanley, D.A., Brown, J.P., Omizo, M., Bone, H.G., Kivitz, A.J., Fuerst, T., Wang, H., Austin, M., and Libanati, C.
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- 2010
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12. Advanced CT based In Vivo Methods for the Assessment of Bone Density, Structure, and Strength
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Engelke, K., Libanati, C., Fuerst, T., Zysset, P., and Genant, H. K.
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- 2013
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13. Short-term in vivo precision of BMD and parameters of trabecular architecture at the distal forearm and tibia
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Engelke, K., Stampa, B., Timm, W., Dardzinski, B., de Papp, A. E., Genant, H. K., and Fuerst, T.
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- 2012
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14. The first multicenter and randomized clinical trial of herbal Fufang for treatment of postmenopausal osteoporosis
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Zhu, H. M., Qin, L., Garnero, P., Genant, H. K., Zhang, G., Dai, K., Yao, X., Gu, G., Hao, Y., Li, Z., Zhao, Y., Li, W., Yang, J., Zhao, X., Shi, D., Fuerst, T., Lu, Y., Li, H., Zhang, X., Li, C., Zhao, J., Wu, Q., and Zhao, S. J.
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- 2012
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15. Effect of monthly ibandronate on hip structural geometry in men with low bone density
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Genant, H. K., Lewiecki, E. M., Fuerst, T., and Fries, M.
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- 2012
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16. The effects of denosumab on cortical bone parameters at the hip and their clinical relevance in women with postmenopausal osteoporosis aged <75 and ≥75 years: FP17
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Genant, H K, Keaveny, T M, Zapalowski, C, Engelke, K, Fuerst, T, Kendler, D L, Recknor, C, Boonen, S, Wang, A, Dakin, P, Libanati, C, and McClung, M R
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- 2014
17. Evaluation of vertebral fracture assessment by dual X-ray absorptiometry in a multicenter setting
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Fuerst, T., Wu, C., Genant, H. K., von Ingersleben, G., Chen, Y., Johnston, C., Econs, M. J., Binkley, N., Vokes, T. J., Crans, G., and Mitlak, B. H.
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- 2009
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18. POS1040 IMPLEMENTATION OF THE OMERACT PSAMRIS IN A PHASE IIB, RANDOMISED PLACEBO-CONTROLLED STUDY OF ABATACEPT IN PSORIATIC ARTHRITIS
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Østergaard, M., primary, Bird, P., additional, Pachai, C., additional, Du, S., additional, Wu, C., additional, Landis, J., additional, Fuerst, T., additional, Ahmad, H. A., additional, Connolly, S., additional, and Conaghan, P. G., additional
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- 2021
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19. Effects of Raloxifene on Fracture Severity in Postmenopausal Women with Osteoporosis: Results from the MORE Study
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Siris, E., Adachi, J. D., Lu, Y., Fuerst, T., Crans, G. G., Wong, M., Harper, K. D., and Genant, H. K.
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- 2002
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20. Standardization of Bone Mineral Density at Femoral Neck, Trochanter and Ward’s Triangle
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Lu, Y., Fuerst, T., Hui, S., and Genant, H. K.
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- 2001
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21. Is Quantitative Ultrasound Dependent on Bone Structure? A Reflection
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Njeh, C. F., Fuerst, T., Diessel, E., and Genant, H. K.
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- 2001
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22. Quantitative Ultrasound of the Tibia Depends on Both Cortical Density and Thickness
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Prevrhal, S., Fuerst, T., Fan, B., Njeh, C., Hans, D., Uffmann, M., Srivastav, S., and Genant, H. K.
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- 2001
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23. Comparison of Six Calcaneal Quantitative Ultrasound Devices: Precision and Hip Fracture Discrimination
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Njeh, C. F., Hans, D., Li, J., Fan, B., Fuerst, T., He, Y. Q., Tsuda-Futami, E., Lu, Y., Wu, C. Y., and Genant, H. K.
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- 2000
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24. Assessment of a New Quantitative Ultrasound Calcaneus Measurement: Precision and Discrimination of Hip Fractures in Elderly Women Compared with Dual X-ray Absorptiometry
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He, Y. Q., Fan, B., Hans, D., Li, J., Wu, C. Y., Njeh, C. F., Zhao, S., Lu, Y., Tsuda-Futami, E., Fuerst, T., and Genant, H. K.
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- 2000
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25. Factors Affecting Broadband Ultrasound Attenuation Results of the Calcaneus Using a Gel-Coupled Quantitative Ultrasound Scanning System
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Cheng, S., Fan, B., Wang, L., Fuerst, T., Lian, M., Njeh, C., He, Y., Kern, M., Lappin, M., Tylavsky, F., Casal, D., Harris, S., and Genant, H. K.
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- 1999
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26. Quantitative Bone Mineral Assessment at the Forearm: A Review
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Augat, P., Fuerst, T., and Genant, H. K.
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- 1998
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27. Ultrasound Characterization of Bone Demineralization
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Wu, C., Glüer, C., Lu, Y., Fuerst, T., Hans, D., and Genant, H. K.
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- 1998
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28. Quantitative ultrasound bone measurement
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Hans, D., Fuerst, T., and Duboeuf, F.
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- 1997
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29. Advances in the noninvasive assessment of bone density, quality, and structure
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Genant, H. K., Lang, T. F., Engelke, K., Fuerst, T., Giüer, C. -C., Majumdar, S., and Jergas, M.
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- 1996
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30. Spinal bone mineral assessment in postmenopausal women: A comparison between dual X-ray absorptiometry and quantitative computed tomography
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Yu, W., Glüer, C., Grampp, S., Jergas, M., Fuerst, T., Wu, C. Y., Lu, Y., Fan, B., and Genant, H. K.
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- 1995
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31. Influence of degenerative joint disease on spinal bone mineral measurements in postmenopausal women
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Yu, W., Glüer, C. -C., Fuerst, T., Grampp, S., Li, J., Lu, Y., and Genant, H. K.
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- 1995
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32. Evaluation of a New Body Composition Phantom for Quality Control and Cross-Calibration of DXA Devices.
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Diessel, E, Fuerst, T, Njeh, C F, Tylavsky, F, Cauley, J, Dockrell, M, and Genant, H K
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- 2001
33. Measurement of Changes in Soft Tissue Mass and Fat Mass with Weight Change: Pencil- versus Fan-Beam Dual-Energy X-ray Absorptiometry
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TYLAVSKY, F. A., FUERST, T., NEVITT, M., DOCKRELL, M., WAN, J. Y., CAULEY, J., and HARRIS, T.
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- 2000
34. Comparison of Two Phantoms for Body Composition with Dual-Energy X-ray Absorptiometry
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DIESSEL, E., SHEPHERD, J. A., FUERST, T., GONZALEZ, M., GENANT, H. K., CAREW, B., and LOOKER, A.
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- 2000
35. QCT Analysis Demonstrates Trabecular Density Increases in Osteoporotic Women Treated with a Triphasic Calcium-Based Implant Material Using a Minimally Invasive Local Osteo-Enhancement Procedure
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Engelke, K, additional, Hill, R, additional, Fuerst, T, additional, Huber, B, additional, Howe, J, additional, and Genant, HK, additional
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- 2019
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36. Characterization of coincidence Doppler broadening and positron annihilation lifetime systems at INL
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Taylor, C. N., primary, Fuerst, T. F., additional, and Shimada, M., additional
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- 2019
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37. Estimation of wrist fracture load using phalangeal speed of sound: an in vitro study
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Njeh, C.F, Wu, C, Fan, B, Hans, D, Fuerst, T, He, Y, and Genant, H.K
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- 2000
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38. Association Between QUS and Structural Parameters?
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Njeh, C. F., Fuerst, T., Diessel, E., Genant, H. K., and Forest, F.
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- 2000
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39. Healthcare Access and Quality Index based on mortality from causes amenable to personal health care in 195 countries and territories, 1990-2015: a novel analysis from the Global Burden of Disease Study 2015
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Barber, R., Fullman, N., Sorensen, R., Bollyky, T., McKee, M., Nolte, E., Abajobir, A., Abate, K., Abbafati, C., Abbas, K., Abd-Allah, F., Abdulle, A., Abdurahman, A., Abera, S., Abraham, B., Abreha, G., Adane, K., Adelekan, A., Adetifa, I., Afshin, A., Agarwal, A., Agarwal, S., Agrawal, A., Kiadaliri, A., Ahmadi, A., Ahmed, K., Ahmed, M., Akinyemi, R., Akinyemiju, T., Akseer, N., Al-Aly, Z., Alam, K., Alam, N., Alam, S., Alemu, Z., Alene, K., Alexander, L., Ali, R., Ali, S., Alizadeh-Navaei, R., Alkerwi, A., Alla, F., Allebeck, P., Allen, C., Al-Raddadi, R., Alsharif, U., Altirkawi, K., Martin, E., Alvis-Guzman, N., Amare, A., Amini, E., Ammar, W., Amo-Adjei, J., Amoako, Y., Anderson, B., Androudi, S., Ansari, H., Ansha, M., Antonio, C., Aernloev, J., Artaman, A., Asayesh, H., Assadi, R., Astatkie, A., Atey, T., Atique, S., Atnafu, N., Atre, S., Avila-Burgos, L., Avokpaho, E., Quintanilla, B., Awasthi, A., Ayele, N., Azzopardi, P., Saleem, H., Baernighausen, T., Bacha, U., Badawi, A., Banerjee, A., Barac, A., Barboza, M., Barker-Collo, S., Barrero, L., Basu, S., Baune, B., Baye, K., Bayou, Y., Bazargan-Hejazi, S., Bedi, N., Beghi, E., Bejot, Y., Bello, A., Bennett, D., Bensenor, I., Berhane, A., Bernabe, E., Bernal, O., Beyene, A., Beyene, T., Bhutta, Z., Biadgilign, S., Bikbov, B., Birlik, S., Birungi, C., Biryukov, S., Bisanzio, D., Bizuayehu, H., Bose, D., Brainin, M., Brauer, M., Brazinova, A., Breitborde, N., Brenner, H., Butt, Z., Cardenas, R., Cahuana-Hurtado, L., Campos-Nonato, I., Car, J., Carrero, J., Casey, D., Caso, V., Castaneda-Orjuela, C., Rivas, J., Catala-Lopez, F., Cecilio, P., Cercy, K., Charlson, F., Chen, A., Chew, A., Chibalabala, M., Chibueze, C., Chisumpa, V., Chitheer, A., Chowdhury, R., Christensen, H., Christopher, D., Ciobanu, L., Cirillo, M., Coggeshall, M., Cooper, L., Cortinovis, M., Crump, J., Dalal, K., Dandona, L., Dandona, R., Dargan, P., das Neves, J., Davey, G., Davitoiu, D., Davletov, K., De Leo, D., Del Gobbo, L., del Pozo-Cruz, B., Dellavalle, R., Deribe, K., Deribew, A., Jarlais, D., Dey, S., Dharmaratne, S., Dicker, D., Ding, E., Dokova, K., Dorsey, E., Doyle, K., Dubey, M., Ehrenkranz, R., Ellingsen, C., Elyazar, I., Enayati, A., Ermakov, S., Eshrati, B., Esteghamati, A., Estep, K., Fuerst, T., Faghmous, I., Fanuel, F., Faraon, E., Farid, T., Farinha, C., Faro, A., Farvid, M., Farzadfar, F., Feigin, V., Feigl, A., Fereshtehnejad, S., Fernandes, J., Feyissa, T., Fischer, F., Fitzmaurice, C., Fleming, T., Foigt, N., Foreman, K., Forouzanfar, M., Franklin, R., Frostad, J., hiwot, T., Gakidou, E., Gambashidze, K., Gamkrelidze, A., Gao, W., Garcia-Basteiro, A., Gebre, T., Gebremedhin, A., Gebremichael, M., Gebru, A., Gelaye, A., Geleijnse, J., Genova-Maleras, R., Gibney, K., Giref, A., Gishu, M., Giussani, G., Godwin, W., Gold, A., Goldberg, E., Gona, P., Goodridge, A., Gopalani, S., Goto, A., Graetz, N., Greaves, F., Griswold, M., Guban, P., Gugnani, H., Gupta, P., Gupta, R., Gupta, T., Gupta, V., Habtewold, T., Hafezi-Nejad, N., Haile, D., Hailu, A., Hailu, G., Hakuzimana, A., Hamadeh, R., Hambisa, M., Hamidi, S., Hammami, M., Hankey, G., Hao, Y., Harb, H., Hareri, H., Haro, J., Hassanvand, M., Havmoeller, R., Hay, R., Hay, S., Hendrie, Delia, Heredia-Pi, I., Hoek, H., Horino, M., Horita, N., Hosgood, H., Htet, A., Hu, G., Huang, H., Huang, J., Huntley, B., Huynh, C., Iburg, K., Ileanu, B., Innos, K., Irenso, A., Jahanmehr, N., Jakovljevic, M., James, P., James, S., Javanbakht, M., Jayaraman, S., Jayatilleke, A., Jeemon, P., Jha, V., John, D., Johnson, C., Johnson, S., Jonas, J., Juel, K., Kabir, Z., Kalkonde, Y., Kamal, R., Kan, H., Karch, A., Karema, C., Karimi, S., Kasaeian, A., Kassebaum, N., Kastor, A., Katikireddi, S., Kazanjan, K., Keiyoro, P., Kemmer, L., Kemp, A., Kengne, A., Kerbo, A., Kereselidze, M., Kesavachandran, C., Khader, Y., Khalil, I., Khan, A., Khan, E., Khan, G., Khang, Y., Khoja, A., Khonelidze, I., Khubchandani, J., Kibret, G., Kim, D., Kim, P., Kim, Y., Kimokoti, R., Kinfu, Y., Kissoon, N., Kivipelto, M., Kokubo, Y., Kolk, A., Kolte, D., Kopec, J., Kosen, S., Koul, P., Koyanagi, A., Kravchenko, M., Krishnaswami, S., Krohn, K., Defo, B., Bicer, B., Kuipers, E., Kulkarni, V., Kumar, G., Kumsa, F., Kutz, M., Kyu, H., Lager, A., Lal, A., Lal, D., Lalloo, R., Lallukka, T., Lan, Q., Langan, S., Lansingh, V., Larson, H., Larsson, A., Laryea, D., Latif, A., Lawrynowicz, A., Leasher, J., Leigh, J., Leinsalu, M., Leshargie, C., Leung, J., Leung, R., Levi, M., Liang, X., Lim, S., Lind, M., Linn, S., Lipshultz, S., Liu, P., Liu, Y., Lo, L., Logroscino, G., Lopez, A., Lorch, S., Lotufo, P., Lozano, R., Lunevicius, R., Lyons, R., Macarayan, E., Mackay, M., El Razek, H., El Razek, M., Mahdavi, M., Majeed, A., Malekzadeh, R., Malta, D., Mantovani, L., Manyazewal, T., Mapoma, C., Marcenes, W., Marks, G., Marquez, N., Martinez-Raga, J., Marzan, M., Massano, J., Mathur, M., Maulik, P., Mazidi, M., McAlinden, C., McGrath, J., McNellan, C., Meaney, P., Mehari, A., Mehndiratta, M., Meier, T., Mekonnen, A., Meles, K., Memish, Z., Mengesha, M., Mengiste, D., Mengistie, M., Menota, B., Mensah, G., Mereta, S., Meretoja, A., Meretoja, T., Mezgebe, H., Micha, R., Millear, A., Mills, E., Minnig, S., Mirarefin, M., Mirrakhimov, E., Mock, C., Mohammad, K., Mohammed, S., Mohanty, S., Mokdad, A., Mola, G., Molokhia, M., Monasta, L., Montico, M., Moradi-Lakeh, M., Moraga, P., Morawska, L., Mori, R., Moses, M., Mueller, U., Murthy, S., Musa, K., Nachega, J., Nagata, C., Nagel, G., Naghavi, M., Naheed, A., Naldi, L., Nangia, V., Nascimento, B., Negoi, I., Neupane, S., Newton, C., Ng, M., Ngalesoni, F., Ngunjiri, J., Nguyen, G., Ningrum, D., Nolte, S., Nomura, M., Norheim, O., Norrving, B., Noubiap, J., Obermeyer, C., Ogbo, F., Oh, I., Okoro, A., Oladimeji, O., Olagunju, A., Olivares, P., Olsen, H., Olusanya, B., Olusanya, J., Opio, J., Oren, E., Ortiz, A., Osborne, R., Osman, M., Owolabi, M., Mahesh, P., Pain, A., Pakhale, S., Castillo, E., Pana, A., Papachristou, C., Parsaeian, M., Patel, T., Patton, G., Paudel, D., Paul, V., Pearce, N., Pereira, D., Perez-Padilla, R., Perez-Ruiz, F., Perico, N., Pesudovs, K., Petzold, M., Phillips, M., Pigott, D., Pillay, J., Pinho, C., Polinder, S., Pond, C., Prakash, V., Purwar, M., Qorbani, M., Quistberg, D., Radfar, A., Rafay, A., Rahimi, K., Rahimi-Movaghar, V., Rahman, M., Rai, R., Ram, U., Rana, S., Rankin, Z., Rao, P., Rawaf, S., Rego, M., Reitsma, M., Remuzzi, G., Renzaho, A., Resnikoff, S., Rezaei, S., Rezai, M., Ribeiro, A., Roba, H., Rokni, M., Ronfani, L., Roshandel, G., Roth, G., Rothenbacher, D., Roy, N., Sachdev, P., Sackey, B., Saeedi, M., Safiri, S., Sagar, R., Sahraian, M., Saleh, M., Salomon, J., Samy, A., Sanabria, J., Sanchez-Nino, M., Sandar, L., Santos, I., Santos, J., Milicevic, M., Sarmiento-Suarez, R., Sartorius, B., Satpathy, M., Savic, M., Sawhney, M., Saylan, M., Schoettker, B., Schutte, A., Schwebel, D., Seedat, S., Seid, A., Seifu, C., Sepanlou, S., Serdar, B., Servan-Mori, E., Setegn, T., Shackelford, K., Shaheen, A., Shahraz, S., Shaikh, M., Shakh-Nazarova, M., Shamsipour, M., Islam, S., Sharma, J., Sharma, R., She, J., Sheikhbahaei, S., Shen, J., Shi, P., Shigematsu, M., Shin, M., Shiri, R., Shoman, H., Shrime, M., Sibamo, E., Sigfusdottir, I., Silva, D., Silveira, D., Sindi, S., Singh, A., Singh, J., Singh, O., Singh, P., Singh, V., Sinke, A., Sinshaw, A., Skirbekk, V., Sliwa, K., Smith, A., Sobngwi, E., Soneji, S., Soriano, J., Sousa, T., Sposato, L., Sreeramareddy, C., Stathopoulou, V., Steel, N., Steiner, C., Steinke, S., Stokes, M., Stranges, S., Strong, M., Stroumpoulis, K., Sturua, L., Sufiyan, M., Suliankatchi, R., Sun, J., Sur, P., Swaminathan, S., Sykes, B., Tabares-Seisdedos, R., Tabb, K., Taffere, G., Talongwa, R., Tarajia, M., Tavakkoli, M., Taveira, N., Teeple, S., Tegegne, T., Tehrani-Banihashemi, A., Tekelab, T., Tekle, D., Shifa, G., Terkawi, A., Tesema, A., Thakur, J., Thomson, A., Tillmann, T., Tiruye, T., Tobe-Gai, R., Tonelli, M., Topor-Madry, R., Tortajada, M., Troeger, C., Truelsen, T., Tura, A., Uchendu, U., Ukwaja, K., Undurraga, E., Uneke, C., Uthman, O., van Boven, J., Van Dingenen, R., Varughese, S., Vasankari, T., Venketasubramanian, N., Violante, F., Vladimirov, S., Vlassov, V., Vollset, S., Vos, T., Wagner, J., Wakayo, T., Waller, S., Walson, J., Wang, H., Wang, Y., Watkins, D., Weiderpass, E., Weintraub, R., Wen, C., Werdecker, A., Wesana, J., Westerman, R., Whiteford, H., Wilkinson, J., Wiysonge, C., Woldeyes, B., Wolfe, C., Won, S., Workicho, A., Workie, S., Wubshet, M., Xavier, D., Xu, G., Yadav, A., Yaghoubi, M., Yakob, B., Yan, L., Yano, Y., Yaseri, M., Yimam, H., Yip, P., Yonemoto, N., Yoon, S., Younis, M., Yu, C., Zaidi, Z., Zaki, M., Zambrana-Torrelio, C., Zapata, T., Zenebe, Z., Zodpey, S., Zoeckler, L., Zuhlke, L., Murray, C., Barber, R., Fullman, N., Sorensen, R., Bollyky, T., McKee, M., Nolte, E., Abajobir, A., Abate, K., Abbafati, C., Abbas, K., Abd-Allah, F., Abdulle, A., Abdurahman, A., Abera, S., Abraham, B., Abreha, G., Adane, K., Adelekan, A., Adetifa, I., Afshin, A., Agarwal, A., Agarwal, S., Agrawal, A., Kiadaliri, A., Ahmadi, A., Ahmed, K., Ahmed, M., Akinyemi, R., Akinyemiju, T., Akseer, N., Al-Aly, Z., Alam, K., Alam, N., Alam, S., Alemu, Z., Alene, K., Alexander, L., Ali, R., Ali, S., Alizadeh-Navaei, R., Alkerwi, A., Alla, F., Allebeck, P., Allen, C., Al-Raddadi, R., Alsharif, U., Altirkawi, K., Martin, E., Alvis-Guzman, N., Amare, A., Amini, E., Ammar, W., Amo-Adjei, J., Amoako, Y., Anderson, B., Androudi, S., Ansari, H., Ansha, M., Antonio, C., Aernloev, J., Artaman, A., Asayesh, H., Assadi, R., Astatkie, A., Atey, T., Atique, S., Atnafu, N., Atre, S., Avila-Burgos, L., Avokpaho, E., Quintanilla, B., Awasthi, A., Ayele, N., Azzopardi, P., Saleem, H., Baernighausen, T., Bacha, U., Badawi, A., Banerjee, A., Barac, A., Barboza, M., Barker-Collo, S., Barrero, L., Basu, S., Baune, B., Baye, K., Bayou, Y., Bazargan-Hejazi, S., Bedi, N., Beghi, E., Bejot, Y., Bello, A., Bennett, D., Bensenor, I., Berhane, A., Bernabe, E., Bernal, O., Beyene, A., Beyene, T., Bhutta, Z., Biadgilign, S., Bikbov, B., Birlik, S., Birungi, C., Biryukov, S., Bisanzio, D., Bizuayehu, H., Bose, D., Brainin, M., Brauer, M., Brazinova, A., Breitborde, N., Brenner, H., Butt, Z., Cardenas, R., Cahuana-Hurtado, L., Campos-Nonato, I., Car, J., Carrero, J., Casey, D., Caso, V., Castaneda-Orjuela, C., Rivas, J., Catala-Lopez, F., Cecilio, P., Cercy, K., Charlson, F., Chen, A., Chew, A., Chibalabala, M., Chibueze, C., Chisumpa, V., Chitheer, A., Chowdhury, R., Christensen, H., Christopher, D., Ciobanu, L., Cirillo, M., Coggeshall, M., Cooper, L., Cortinovis, M., Crump, J., Dalal, K., Dandona, L., Dandona, R., Dargan, P., das Neves, J., Davey, G., Davitoiu, D., Davletov, K., De Leo, D., Del Gobbo, L., del Pozo-Cruz, B., Dellavalle, R., Deribe, K., Deribew, A., Jarlais, D., Dey, S., Dharmaratne, S., Dicker, D., Ding, E., Dokova, K., Dorsey, E., Doyle, K., Dubey, M., Ehrenkranz, R., Ellingsen, C., Elyazar, I., Enayati, A., Ermakov, S., Eshrati, B., Esteghamati, A., Estep, K., Fuerst, T., Faghmous, I., Fanuel, F., Faraon, E., Farid, T., Farinha, C., Faro, A., Farvid, M., Farzadfar, F., Feigin, V., Feigl, A., Fereshtehnejad, S., Fernandes, J., Feyissa, T., Fischer, F., Fitzmaurice, C., Fleming, T., Foigt, N., Foreman, K., Forouzanfar, M., Franklin, R., Frostad, J., hiwot, T., Gakidou, E., Gambashidze, K., Gamkrelidze, A., Gao, W., Garcia-Basteiro, A., Gebre, T., Gebremedhin, A., Gebremichael, M., Gebru, A., Gelaye, A., Geleijnse, J., Genova-Maleras, R., Gibney, K., Giref, A., Gishu, M., Giussani, G., Godwin, W., Gold, A., Goldberg, E., Gona, P., Goodridge, A., Gopalani, S., Goto, A., Graetz, N., Greaves, F., Griswold, M., Guban, P., Gugnani, H., Gupta, P., Gupta, R., Gupta, T., Gupta, V., Habtewold, T., Hafezi-Nejad, N., Haile, D., Hailu, A., Hailu, G., Hakuzimana, A., Hamadeh, R., Hambisa, M., Hamidi, S., Hammami, M., Hankey, G., Hao, Y., Harb, H., Hareri, H., Haro, J., Hassanvand, M., Havmoeller, R., Hay, R., Hay, S., Hendrie, Delia, Heredia-Pi, I., Hoek, H., Horino, M., Horita, N., Hosgood, H., Htet, A., Hu, G., Huang, H., Huang, J., Huntley, B., Huynh, C., Iburg, K., Ileanu, B., Innos, K., Irenso, A., Jahanmehr, N., Jakovljevic, M., James, P., James, S., Javanbakht, M., Jayaraman, S., Jayatilleke, A., Jeemon, P., Jha, V., John, D., Johnson, C., Johnson, S., Jonas, J., Juel, K., Kabir, Z., Kalkonde, Y., Kamal, R., Kan, H., Karch, A., Karema, C., Karimi, S., Kasaeian, A., Kassebaum, N., Kastor, A., Katikireddi, S., Kazanjan, K., Keiyoro, P., Kemmer, L., Kemp, A., Kengne, A., Kerbo, A., Kereselidze, M., Kesavachandran, C., Khader, Y., Khalil, I., Khan, A., Khan, E., Khan, G., Khang, Y., Khoja, A., Khonelidze, I., Khubchandani, J., Kibret, G., Kim, D., Kim, P., Kim, Y., Kimokoti, R., Kinfu, Y., Kissoon, N., Kivipelto, M., Kokubo, Y., Kolk, A., Kolte, D., Kopec, J., Kosen, S., Koul, P., Koyanagi, A., Kravchenko, M., Krishnaswami, S., Krohn, K., Defo, B., Bicer, B., Kuipers, E., Kulkarni, V., Kumar, G., Kumsa, F., Kutz, M., Kyu, H., Lager, A., Lal, A., Lal, D., Lalloo, R., Lallukka, T., Lan, Q., Langan, S., Lansingh, V., Larson, H., Larsson, A., Laryea, D., Latif, A., Lawrynowicz, A., Leasher, J., Leigh, J., Leinsalu, M., Leshargie, C., Leung, J., Leung, R., Levi, M., Liang, X., Lim, S., Lind, M., Linn, S., Lipshultz, S., Liu, P., Liu, Y., Lo, L., Logroscino, G., Lopez, A., Lorch, S., Lotufo, P., Lozano, R., Lunevicius, R., Lyons, R., Macarayan, E., Mackay, M., El Razek, H., El Razek, M., Mahdavi, M., Majeed, A., Malekzadeh, R., Malta, D., Mantovani, L., Manyazewal, T., Mapoma, C., Marcenes, W., Marks, G., Marquez, N., Martinez-Raga, J., Marzan, M., Massano, J., Mathur, M., Maulik, P., Mazidi, M., McAlinden, C., McGrath, J., McNellan, C., Meaney, P., Mehari, A., Mehndiratta, M., Meier, T., Mekonnen, A., Meles, K., Memish, Z., Mengesha, M., Mengiste, D., Mengistie, M., Menota, B., Mensah, G., Mereta, S., Meretoja, A., Meretoja, T., Mezgebe, H., Micha, R., Millear, A., Mills, E., Minnig, S., Mirarefin, M., Mirrakhimov, E., Mock, C., Mohammad, K., Mohammed, S., Mohanty, S., Mokdad, A., Mola, G., Molokhia, M., Monasta, L., Montico, M., Moradi-Lakeh, M., Moraga, P., Morawska, L., Mori, R., Moses, M., Mueller, U., Murthy, S., Musa, K., Nachega, J., Nagata, C., Nagel, G., Naghavi, M., Naheed, A., Naldi, L., Nangia, V., Nascimento, B., Negoi, I., Neupane, S., Newton, C., Ng, M., Ngalesoni, F., Ngunjiri, J., Nguyen, G., Ningrum, D., Nolte, S., Nomura, M., Norheim, O., Norrving, B., Noubiap, J., Obermeyer, C., Ogbo, F., Oh, I., Okoro, A., Oladimeji, O., Olagunju, A., Olivares, P., Olsen, H., Olusanya, B., Olusanya, J., Opio, J., Oren, E., Ortiz, A., Osborne, R., Osman, M., Owolabi, M., Mahesh, P., Pain, A., Pakhale, S., Castillo, E., Pana, A., Papachristou, C., Parsaeian, M., Patel, T., Patton, G., Paudel, D., Paul, V., Pearce, N., Pereira, D., Perez-Padilla, R., Perez-Ruiz, F., Perico, N., Pesudovs, K., Petzold, M., Phillips, M., Pigott, D., Pillay, J., Pinho, C., Polinder, S., Pond, C., Prakash, V., Purwar, M., Qorbani, M., Quistberg, D., Radfar, A., Rafay, A., Rahimi, K., Rahimi-Movaghar, V., Rahman, M., Rai, R., Ram, U., Rana, S., Rankin, Z., Rao, P., Rawaf, S., Rego, M., Reitsma, M., Remuzzi, G., Renzaho, A., Resnikoff, S., Rezaei, S., Rezai, M., Ribeiro, A., Roba, H., Rokni, M., Ronfani, L., Roshandel, G., Roth, G., Rothenbacher, D., Roy, N., Sachdev, P., Sackey, B., Saeedi, M., Safiri, S., Sagar, R., Sahraian, M., Saleh, M., Salomon, J., Samy, A., Sanabria, J., Sanchez-Nino, M., Sandar, L., Santos, I., Santos, J., Milicevic, M., Sarmiento-Suarez, R., Sartorius, B., Satpathy, M., Savic, M., Sawhney, M., Saylan, M., Schoettker, B., Schutte, A., Schwebel, D., Seedat, S., Seid, A., Seifu, C., Sepanlou, S., Serdar, B., Servan-Mori, E., Setegn, T., Shackelford, K., Shaheen, A., Shahraz, S., Shaikh, M., Shakh-Nazarova, M., Shamsipour, M., Islam, S., Sharma, J., Sharma, R., She, J., Sheikhbahaei, S., Shen, J., Shi, P., Shigematsu, M., Shin, M., Shiri, R., Shoman, H., Shrime, M., Sibamo, E., Sigfusdottir, I., Silva, D., Silveira, D., Sindi, S., Singh, A., Singh, J., Singh, O., Singh, P., Singh, V., Sinke, A., Sinshaw, A., Skirbekk, V., Sliwa, K., Smith, A., Sobngwi, E., Soneji, S., Soriano, J., Sousa, T., Sposato, L., Sreeramareddy, C., Stathopoulou, V., Steel, N., Steiner, C., Steinke, S., Stokes, M., Stranges, S., Strong, M., Stroumpoulis, K., Sturua, L., Sufiyan, M., Suliankatchi, R., Sun, J., Sur, P., Swaminathan, S., Sykes, B., Tabares-Seisdedos, R., Tabb, K., Taffere, G., Talongwa, R., Tarajia, M., Tavakkoli, M., Taveira, N., Teeple, S., Tegegne, T., Tehrani-Banihashemi, A., Tekelab, T., Tekle, D., Shifa, G., Terkawi, A., Tesema, A., Thakur, J., Thomson, A., Tillmann, T., Tiruye, T., Tobe-Gai, R., Tonelli, M., Topor-Madry, R., Tortajada, M., Troeger, C., Truelsen, T., Tura, A., Uchendu, U., Ukwaja, K., Undurraga, E., Uneke, C., Uthman, O., van Boven, J., Van Dingenen, R., Varughese, S., Vasankari, T., Venketasubramanian, N., Violante, F., Vladimirov, S., Vlassov, V., Vollset, S., Vos, T., Wagner, J., Wakayo, T., Waller, S., Walson, J., Wang, H., Wang, Y., Watkins, D., Weiderpass, E., Weintraub, R., Wen, C., Werdecker, A., Wesana, J., Westerman, R., Whiteford, H., Wilkinson, J., Wiysonge, C., Woldeyes, B., Wolfe, C., Won, S., Workicho, A., Workie, S., Wubshet, M., Xavier, D., Xu, G., Yadav, A., Yaghoubi, M., Yakob, B., Yan, L., Yano, Y., Yaseri, M., Yimam, H., Yip, P., Yonemoto, N., Yoon, S., Younis, M., Yu, C., Zaidi, Z., Zaki, M., Zambrana-Torrelio, C., Zapata, T., Zenebe, Z., Zodpey, S., Zoeckler, L., Zuhlke, L., and Murray, C.
- Published
- 2017
40. Global and National Burden of Diseases and Injuries Among Children and Adolescents Between 1990 and 2013 Findings From the Global Burden of Disease 2013 Study
- Author
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Kyu, HH, Pinho, C, Wagner, JA, Brown, JC, Bertozzi-Villa, A, Charlson, FJ, Coffeng, LE, Dandona, L, Erskine, HE, Ferrari, AJ, Fitzmaurice, C, Fleming, TD, Forouzanfar, MH, Graetz, N, Guinovart, C, Haagsma, J, Higashi, H, Kassebaum, NJ, Larson, HJ, Lim, SS, Mokdad, AH, Moradi-Lakeh, M, Odell, SV, Roth, GA, Serina, PT, Stanaway, JD, Misganaw, A, Whiteford, HA, Wolock, TM, Hanson, SW, Abd-Allah, F, Abera, SF, Abu-Raddad, LJ, AlBuhairan, FS, Amare, AT, Antonio, CAT, Artaman, A, Barker-Collo, SL, Barrero, LH, Benjet, C, Bensenor, IM, Bhutta, ZA, Bikbov, B, Brazinova, A, Campos-Nonato, I, Castaneda-Orjuela, CA, Catala-Lopez, F, Chowdhury, R, Cooper, C, Crump, JA, Dandona, R, Degenhardt, L, Dellavalle, RP, Dharmaratne, SD, Faraon, EJA, Feigin, VL, Fuerst, T, Geleijnse, JM, Gessner, BD, Gibney, KB, Goto, A, Gunnell, D, Hankey, GJ, Hay, RJ, Hornberger, JC, Hosgood, HD, Hu, G, Jacobsen, KH, Jayaraman, SP, Jeemon, P, Jonas, JB, Karch, A, Kim, D, Kim, S, Kokubo, Y, Defo, BK, Bicer, BK, Kumar, GA, Larsson, A, Leasher, JL, Leung, R, Li, Y, Lipshultz, SE, Lopez, AD, Lotufo, PA, Lunevicius, R, Lyons, RA, Majdan, M, Malekzadeh, R, Mashal, T, Mason-Jones, AJ, Melaku, YA, Memish, ZA, Mendoza, W, Miller, TR, Mock, CN, Murray, J, Nolte, S, Oh, I-H, Olusanya, BO, Ortblad, KF, Park, E-K, Paternina Caicedo, AJ, Patten, SB, Patton, GC, Pereira, DM, Perico, N, Piel, FB, Polinder, S, Popova, S, Pourmalek, F, Quistberg, DA, Remuzzi, G, Rodriguez, A, Rojas-Rueda, D, Rothenbacher, D, Rothstein, DH, Sanabria, J, Santos, IS, Schwebel, DC, Sepanlou, SG, Shaheen, A, Shiri, R, Shiue, I, Skirbekk, V, Sliwa, K, Sreeramareddy, CT, Stein, DJ, Steiner, TJ, Stovner, LJ, Sykes, BL, Tabb, KM, Terkawi, AS, Thomson, AJ, Thorne-Lyman, AL, Towbin, JA, Ukwaja, KN, Vasankari, T, Venketasubramanian, N, Vlassov, VV, Vollset, SE, Weiderpass, E, Weintraub, RG, Werdecker, A, Wilkinson, JD, Woldeyohannes, SM, Wolfe, CDA, Yano, Y, Yip, P, Yonemoto, N, Yoon, S-J, Younis, MZ, Yu, C, Zaki, MES, Naghavi, M, Murray, CJL, Vos, T, Kyu, HH, Pinho, C, Wagner, JA, Brown, JC, Bertozzi-Villa, A, Charlson, FJ, Coffeng, LE, Dandona, L, Erskine, HE, Ferrari, AJ, Fitzmaurice, C, Fleming, TD, Forouzanfar, MH, Graetz, N, Guinovart, C, Haagsma, J, Higashi, H, Kassebaum, NJ, Larson, HJ, Lim, SS, Mokdad, AH, Moradi-Lakeh, M, Odell, SV, Roth, GA, Serina, PT, Stanaway, JD, Misganaw, A, Whiteford, HA, Wolock, TM, Hanson, SW, Abd-Allah, F, Abera, SF, Abu-Raddad, LJ, AlBuhairan, FS, Amare, AT, Antonio, CAT, Artaman, A, Barker-Collo, SL, Barrero, LH, Benjet, C, Bensenor, IM, Bhutta, ZA, Bikbov, B, Brazinova, A, Campos-Nonato, I, Castaneda-Orjuela, CA, Catala-Lopez, F, Chowdhury, R, Cooper, C, Crump, JA, Dandona, R, Degenhardt, L, Dellavalle, RP, Dharmaratne, SD, Faraon, EJA, Feigin, VL, Fuerst, T, Geleijnse, JM, Gessner, BD, Gibney, KB, Goto, A, Gunnell, D, Hankey, GJ, Hay, RJ, Hornberger, JC, Hosgood, HD, Hu, G, Jacobsen, KH, Jayaraman, SP, Jeemon, P, Jonas, JB, Karch, A, Kim, D, Kim, S, Kokubo, Y, Defo, BK, Bicer, BK, Kumar, GA, Larsson, A, Leasher, JL, Leung, R, Li, Y, Lipshultz, SE, Lopez, AD, Lotufo, PA, Lunevicius, R, Lyons, RA, Majdan, M, Malekzadeh, R, Mashal, T, Mason-Jones, AJ, Melaku, YA, Memish, ZA, Mendoza, W, Miller, TR, Mock, CN, Murray, J, Nolte, S, Oh, I-H, Olusanya, BO, Ortblad, KF, Park, E-K, Paternina Caicedo, AJ, Patten, SB, Patton, GC, Pereira, DM, Perico, N, Piel, FB, Polinder, S, Popova, S, Pourmalek, F, Quistberg, DA, Remuzzi, G, Rodriguez, A, Rojas-Rueda, D, Rothenbacher, D, Rothstein, DH, Sanabria, J, Santos, IS, Schwebel, DC, Sepanlou, SG, Shaheen, A, Shiri, R, Shiue, I, Skirbekk, V, Sliwa, K, Sreeramareddy, CT, Stein, DJ, Steiner, TJ, Stovner, LJ, Sykes, BL, Tabb, KM, Terkawi, AS, Thomson, AJ, Thorne-Lyman, AL, Towbin, JA, Ukwaja, KN, Vasankari, T, Venketasubramanian, N, Vlassov, VV, Vollset, SE, Weiderpass, E, Weintraub, RG, Werdecker, A, Wilkinson, JD, Woldeyohannes, SM, Wolfe, CDA, Yano, Y, Yip, P, Yonemoto, N, Yoon, S-J, Younis, MZ, Yu, C, Zaki, MES, Naghavi, M, Murray, CJL, and Vos, T
- Abstract
IMPORTANCE: The literature focuses on mortality among children younger than 5 years. Comparable information on nonfatal health outcomes among these children and the fatal and nonfatal burden of diseases and injuries among older children and adolescents is scarce. OBJECTIVE: To determine levels and trends in the fatal and nonfatal burden of diseases and injuries among younger children (aged <5 years), older children (aged 5-9 years), and adolescents (aged 10-19 years) between 1990 and 2013 in 188 countries from the Global Burden of Disease (GBD) 2013 study. EVIDENCE REVIEW: Data from vital registration, verbal autopsy studies, maternal and child death surveillance, and other sources covering 14,244 site-years (ie, years of cause of death data by geography) from 1980 through 2013 were used to estimate cause-specific mortality. Data from 35,620 epidemiological sources were used to estimate the prevalence of the diseases and sequelae in the GBD 2013 study. Cause-specific mortality for most causes was estimated using the Cause of Death Ensemble Model strategy. For some infectious diseases (eg, HIV infection/AIDS, measles, hepatitis B) where the disease process is complex or the cause of death data were insufficient or unavailable, we used natural history models. For most nonfatal health outcomes, DisMod-MR 2.0, a Bayesian metaregression tool, was used to meta-analyze the epidemiological data to generate prevalence estimates. FINDINGS: Of the 7.7 (95% uncertainty interval [UI], 7.4-8.1) million deaths among children and adolescents globally in 2013, 6.28 million occurred among younger children, 0.48 million among older children, and 0.97 million among adolescents. In 2013, the leading causes of death were lower respiratory tract infections among younger children (905.059 deaths; 95% UI, 810,304-998,125), diarrheal diseases among older children (38,325 deaths; 95% UI, 30,365-47,678), and road injuries among adolescents (115,186 deaths; 95% UI, 105,185-124,870). Iron defici
- Published
- 2016
41. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015
- Author
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Forouzanfar, M., Afshin, A., Alexander, L., Anderson, H., Bhutta, Z., Biryukov, S., Brauer, M., Burnett, R., Cercy, K., Charlson, F., Cohen, A., Dandona, L., Estep, K., Ferrari, A., Frostad, J., Fullman, N., Gething, P., Godwin, W., Griswold, M., Kinfu, Y., Kyu, H., Larson, H., Liang, X., Lim, S., Liu, P., Lopez, A., Lozano, R., Marczak, L., Mensah, G., Mokdad, A., Moradi-Lakeh, M., Naghavi, M., Neal, B., Reitsma, M., Roth, G., Salomon, J., Sur, P., Vos, T., Wagner, J., Wang, H., Zhao, Y., Zhou, M., Aasvang, G., Abajobir, A., Abate, K., Abbafati, C., Abbas, K., Abd-Allah, F., Abdulle, A., Abera, S., Abraham, B., Abu-Raddad, L., Abyu, G., Adebiyi, A., Adedeji, I., Ademi, Z., Adou, A., Adsuar, J., Agardh, E., Agarwal, A., Agrawal, A., Kiadaliri, A., Ajala, O., Akinyemiju, T., Al-Aly, Z., Alam, K., Alam, N., Aldhahri, S., Aldridge, R., Alemu, Z., Ali, R., Alkerwi, A., Alla, F., Allebeck, P., Alsharif, U., Altirkawi, K., Alvarez Martin, E., Alvis-Guzman, N., Amare, A., Amberbir, A., Amegah, A., Amini, H., Ammar, W., Amrock, S., Andersen, H., Anderson, B., Antonio, C., Anwar, P., Arnlov, J., Al, A., Asayesh, H., Asghar, R., Assadi, R., Atique, S., Avokpaho, E., Awasthi, A., Quintanilla, B., Azzopardi, P., Bacha, U., Badawi, A., Bahit, M., Balakrishnan, K., Barac, A., Barber, R., Barker-Collo, S., Baernighausen, T., Barquera, S., Barregard, L., Barrero, L., Basu, S., Bans, C., Bazargan-Hejazi, S., Beardsley, J., Bedi, N., Beghi, E., Bell, M., Bello, A., Bennett, D., Bensenor, I., Berhane, A., Bernabe, E., Betsu, B., Beyene, A., Bhala, N., Bhansali, A., Bhatt, S., Biadgilign, S., Bikbov, B., Bisanzio, D., Bjertness, E., Blore, J., Borschmann, R., Boufous, S., Bourne, R., Brainin, M., Brazinova, A., Breitborde, N., Brenner, H., Broday, D., Brugha, T., Brunekreef, B., Butt, Z., Cahill, L., Calabria, B., Ricardo Campos-Nonato, I., Cardenas, R., Carpenter, D., Casey, D., Castaneda-Oquela, C., Castillo Rivas, J., Estanislao Castro, R., Catala-Lopez, F., Chang, J., Chiang, P., Chibalabala, M., Chimed-Ochir, O., Chisumpa, V., Chitheer, A., Choi, J., Christensen, H., Christopher, D., Ciobanu, L., Coates, M., Colquhoun, S., Cooper, L., Cooperrider, K., Cornaby, L., Cortinovis, M., Crump, J., Cuevas-Nasu, L., Damasceno, A., Dandona, R., Darby, S., Dargan, P., das Neves, J., Davis, A., Davletov, K., Filipa de Castro, E., De la Cruz-Gongora, V., De Leo, D., Degenhardt, L., Del Gobbo, L., del Pozo-Cruz, B., Dellavalle, R., Deribew, A., Des Jarlais, D., Dharmaratne, S., Dhillon, P., Diaz-Tome, C., Dicker, D., Ding, E., Dorsey, E., Doyle, K., Driscoll, T., Duan, L., Dubey, M., Duncan, B., Elyazar, I., Endries, A., Ermakov, S., Erskine, H., Eshrati, B., Esteghamati, A., Fahimi, S., Aquino Faraon, E., Farid, T., Sofia E Sa Farinha, C., Faro, A., Farvid, M., Farzadfar, F., Feigin, V., Fereshtehnejad, S., Fernandes, J., Fischer, F., Fitchett, J., Fleming, T., Foigt, N., Foreman, K., Fowkes, F., Franklin, R., Fuerst, T., Futran, N., Gakidou, E., Garcia-Basteiro, A., Gebrehiwot, T., Gebremedhin, A., Geleijnse, J., Gessner, B., Giref, A., Giroud, M., Gishu, M., Goenka, S., Carmen Gomez-Cabrera, M., Gomez-Dantes, H., Gona, P., Goodridge, A., Gopalani, S., Gotay, C., Goto, A., Gouda, H., Gugnani, H., Guillemin, F., Guo, Y., Gupta, R., Gutierrez, R., Haagsma, J., Hafezi-Nejad, N., Haile, D., Hailu, G., Halasa, Y., Hamadeh, R., Hamidi, S., Handal, A., Hankey, G., Hao, Y., Harb, H., Harikrishnan, S., Maria Haro, J., Hassanvand, M., Hassen, T., Havmoeller, R., Beatriz Heredia-Pi, I., Francisco Hernandez-Llanes, N., Heydarpour, P., Hoek, H., Hoffman, H., Horino, M., Horita, N., Hosgood, H., Hoy, D., Hsairi, M., Htet, A., Hu, G., Huang, J., Husseini, A., Hutchings, S., Huybrechts, I., Iburg, K., Idrisov, B., Ileanu, B., Inoue, M., Jacobs, T., Jacobsen, K., Jahanmehr, N., Jakovljevic, M., Jansen, H., Jassal, S., Javanbakht, M., Jayatilleke, A., Jee, S., Jeemon, P., Jha, V., Jiang, Y., Jibat, T., Jin, Y., Johnson, C., Jonas, J., Kabir, Z., Kalkonde, Y., Kamal, R., Kan, H., Karch, A., Karema, C., Karimkhani, C., Kasaeian, A., Kaul, A., Kawakami, N., Kazi, D., Keiyoro, P., Kemp, A., Kengne, A., Keren, A., Kesavachandran, C., Khader, Y., Khan, A., Khan, E., Khan, G., Khang, Y., Khatibzadeh, S., Khera, S., Khoja, T., Khubchandani, J., Kieling, C., Kim, C., Kim, D., Kimokoti, R., Kissoon, N., Kivipelto, M., Knibbs, L., Kokubo, Y., Kopec, J., Koul, P., Koyanagi, A., Kravchenko, M., Kromhout, H., Krueger, H., Ku, T., Defo, B., Kuchenbecker, R., Bicer, B., Kuipers, E., Kumar, G., Kwan, G., Lal, D., Lalloo, R., Lallukka, T., Lan, Q., Larsson, A., Latif, A., Beatriz Lawrynowicz, A., Leasher, J., Leigh, J., Leung, J., Levi, M., Li, X., Li, Y., Liang, J., Liu, S., Lloyd, B., Logroscino, G., Lotufo, P., Lunevicius, R., Maclntyre, M., Mahdavi, M., Majdan, M., Majeed, A., Malekzadeh, R., Malta, D., Manamo, W., Mapoma, C., Marcenes, W., Martin, R., Martinez-Raga, J., Masiye, F., Matsushita, K., Matzopoulos, R., Mayosi, B., McGrath, J., McKee, M., Meaney, P., Medina, C., Mehari, A., Mena-Rodriguez, F., Mekonnen, A., Melaku, Y., Memish, Z., Mendoza, W., Mensink, G., Meretoja, A., Meretoja, T., Mesfin, Y., Mhimbira, F., Miller, Ted, Mills, E., Mirarefin, M., Misganaw, A., Mock, C., Mohammadi, A., Mohammed, S., Mola, G., Monasta, L., Montanez Hernandez, J., Montico, M., Morawska, L., Mori, R., Mozaffarian, D., Mueller, U., Mullany, E., Mumford, J., Murthy, G., Nachega, J., Naheed, A., Nangia, V., Nassiri, N., Newton, J., Ng, M., Quyen, L., Nisar, M., Pete, P., Norheim, O., Norman, R., Norrving, B., Nyakarahuka, L., Obermeyer, C., Ogbo, F., Oh, I., Oladimeji, O., Olivares, P., Olsen, H., Olusanya, B., Olusanya, J., Opio, J., Oren, E., Orozco, R., Ortiz, A., Ota, E., Mahesh, P., Pana, A., Park, E., Parry, C., Parsaeian, M., Patel, T., Caicedo, A., Patil, S., Patten, S., Patton, G., Pearce, N., Pereira, D., Perico, N., Pesudovs, K., Petzold, M., Phillips, M., Piel, F., Pillay, J., Plass, D., Polinder, S., Pond, C., Pope, C., Pope, D., Popova, S., Poulton, R., Pourmalek, F., Prasad, N., Qorbani, M., Rabiee, R., Radfar, A., Rafay, A., Rahimi-Movaghar, V., Rahman, M., Rahman, S., Rai, R., Rajsic, S., Raju, M., Ram, U., Rana, S., Ranganathan, K., Rao, P., Razo Garcia, C., Refaat, A., Rehm, C., Rehm, J., Reinig, N., Remuzzi, G., Resnikoff, S., Ribeiro, A., Rivera, J., Rolm, H., Rodriguez, A., Rodriguez-Ramirez, S., Rojas-Rueda, D., Roman, Y., Ronfani, L., Roshandel, G., Rothenbacher, D., Roy, A., Saleh, M., Sanabria, J., Dolores Sanchez-Nino, M., Sanchez-Pimienta, T., Sandar, L., Santomauro, D., Santos, I., Sarmiento-Suarez, R., Sartorius, B., Satpathy, M., Savic, M., Sawhney, M., Schmidhuber, J., Schmidt, M., Schneider, I., Schoettker, B., Schutte, A., Schwebel, D., Scott, J., Seedat, S., Sepanlou, S., Servan-Mori, E., Shaheen, A., Shahraz, S., Shaikh, M., Levy, T., Sharma, R., She, J., Sheikhbahaei, S., Shen, J., Sheth, K., Shi, P., Shibuya, K., Shigematsu, M., Shin, M., Shiri, R., Shishani, K., Shiue, I., Shrime, M., Sigfusdottir, I., Silva, D., Alves Silveira, D., Silverberg, J., Simard, E., Sindi, S., Singh, A., Singh, J., Singh, P., Slepak, E., Soljak, M., Soneji, S., Sorensen, R., Sposato, L., Sreeramareddy, C., Stathopoulou, V., Steckling, N., Steel, N., Stein, D., Stein, M., Stockl, H., Stranges, S., Stroumpoulis, K., Sunguya, B., Swaminathan, S., Sykes, B., Szoeke, C., Tabares-Seisdedos, R., Takahashi, K., Talongwa, R., Landon, N., Tanne, D., Tavakkoli, M., Taye, B., Taylor, H., Tedla, B., Tefera, W., Tegegne, T., Tekle, D., Terkawi, A., Thakur, J., Thomas, B., Thomas, M., Thomson, A., Thorne-Lyman, A., Thrift, A., Thurston, G., Tillmann, T., Tobe-Gai, R., Tobollik, M., Topor-Madry, R., Topouzis, F., Towbin, J., Bach, X., Dimbuene, Z., Tsilimparis, N., Tura, A., Tuzcu, E., Tyrovolas, S., Ukwaja, K., Undurraga, E., Uneke, C., Uthman, O., van Donkelaar, A., van Os, J., Varakin, Y., Vasankari, T., Veerman, J., Venketasubramanian, N., Violante, F., Vollset, S., Wagner, G., Waller, S., Wang, J., Wang, L., Wang, Y., Weichenthal, S., Weiderpass, E., Weintraub, R., Werdecker, A., Westerman, R., Whiteford, H., Wijeratne, T., Wiysonge, C., Wolfe, C., Won, S., Woolf, A., Wubshet, M., Xavier, D., Xu, G., Yadav, A., Yakob, B., Yalew, A., Yano, Y., Yaseri, M., Ye, P., Yip, P., Yonemoto, N., Yoon, S., Younis, M., Yu, C., Zaidi, Z., Zaki, M., Zhu, J., Zipkin, B., Zodpey, S., Zuhlke, L., Murray, C., Forouzanfar, M., Afshin, A., Alexander, L., Anderson, H., Bhutta, Z., Biryukov, S., Brauer, M., Burnett, R., Cercy, K., Charlson, F., Cohen, A., Dandona, L., Estep, K., Ferrari, A., Frostad, J., Fullman, N., Gething, P., Godwin, W., Griswold, M., Kinfu, Y., Kyu, H., Larson, H., Liang, X., Lim, S., Liu, P., Lopez, A., Lozano, R., Marczak, L., Mensah, G., Mokdad, A., Moradi-Lakeh, M., Naghavi, M., Neal, B., Reitsma, M., Roth, G., Salomon, J., Sur, P., Vos, T., Wagner, J., Wang, H., Zhao, Y., Zhou, M., Aasvang, G., Abajobir, A., Abate, K., Abbafati, C., Abbas, K., Abd-Allah, F., Abdulle, A., Abera, S., Abraham, B., Abu-Raddad, L., Abyu, G., Adebiyi, A., Adedeji, I., Ademi, Z., Adou, A., Adsuar, J., Agardh, E., Agarwal, A., Agrawal, A., Kiadaliri, A., Ajala, O., Akinyemiju, T., Al-Aly, Z., Alam, K., Alam, N., Aldhahri, S., Aldridge, R., Alemu, Z., Ali, R., Alkerwi, A., Alla, F., Allebeck, P., Alsharif, U., Altirkawi, K., Alvarez Martin, E., Alvis-Guzman, N., Amare, A., Amberbir, A., Amegah, A., Amini, H., Ammar, W., Amrock, S., Andersen, H., Anderson, B., Antonio, C., Anwar, P., Arnlov, J., Al, A., Asayesh, H., Asghar, R., Assadi, R., Atique, S., Avokpaho, E., Awasthi, A., Quintanilla, B., Azzopardi, P., Bacha, U., Badawi, A., Bahit, M., Balakrishnan, K., Barac, A., Barber, R., Barker-Collo, S., Baernighausen, T., Barquera, S., Barregard, L., Barrero, L., Basu, S., Bans, C., Bazargan-Hejazi, S., Beardsley, J., Bedi, N., Beghi, E., Bell, M., Bello, A., Bennett, D., Bensenor, I., Berhane, A., Bernabe, E., Betsu, B., Beyene, A., Bhala, N., Bhansali, A., Bhatt, S., Biadgilign, S., Bikbov, B., Bisanzio, D., Bjertness, E., Blore, J., Borschmann, R., Boufous, S., Bourne, R., Brainin, M., Brazinova, A., Breitborde, N., Brenner, H., Broday, D., Brugha, T., Brunekreef, B., Butt, Z., Cahill, L., Calabria, B., Ricardo Campos-Nonato, I., Cardenas, R., Carpenter, D., Casey, D., Castaneda-Oquela, C., Castillo Rivas, J., Estanislao Castro, R., Catala-Lopez, F., Chang, J., Chiang, P., Chibalabala, M., Chimed-Ochir, O., Chisumpa, V., Chitheer, A., Choi, J., Christensen, H., Christopher, D., Ciobanu, L., Coates, M., Colquhoun, S., Cooper, L., Cooperrider, K., Cornaby, L., Cortinovis, M., Crump, J., Cuevas-Nasu, L., Damasceno, A., Dandona, R., Darby, S., Dargan, P., das Neves, J., Davis, A., Davletov, K., Filipa de Castro, E., De la Cruz-Gongora, V., De Leo, D., Degenhardt, L., Del Gobbo, L., del Pozo-Cruz, B., Dellavalle, R., Deribew, A., Des Jarlais, D., Dharmaratne, S., Dhillon, P., Diaz-Tome, C., Dicker, D., Ding, E., Dorsey, E., Doyle, K., Driscoll, T., Duan, L., Dubey, M., Duncan, B., Elyazar, I., Endries, A., Ermakov, S., Erskine, H., Eshrati, B., Esteghamati, A., Fahimi, S., Aquino Faraon, E., Farid, T., Sofia E Sa Farinha, C., Faro, A., Farvid, M., Farzadfar, F., Feigin, V., Fereshtehnejad, S., Fernandes, J., Fischer, F., Fitchett, J., Fleming, T., Foigt, N., Foreman, K., Fowkes, F., Franklin, R., Fuerst, T., Futran, N., Gakidou, E., Garcia-Basteiro, A., Gebrehiwot, T., Gebremedhin, A., Geleijnse, J., Gessner, B., Giref, A., Giroud, M., Gishu, M., Goenka, S., Carmen Gomez-Cabrera, M., Gomez-Dantes, H., Gona, P., Goodridge, A., Gopalani, S., Gotay, C., Goto, A., Gouda, H., Gugnani, H., Guillemin, F., Guo, Y., Gupta, R., Gutierrez, R., Haagsma, J., Hafezi-Nejad, N., Haile, D., Hailu, G., Halasa, Y., Hamadeh, R., Hamidi, S., Handal, A., Hankey, G., Hao, Y., Harb, H., Harikrishnan, S., Maria Haro, J., Hassanvand, M., Hassen, T., Havmoeller, R., Beatriz Heredia-Pi, I., Francisco Hernandez-Llanes, N., Heydarpour, P., Hoek, H., Hoffman, H., Horino, M., Horita, N., Hosgood, H., Hoy, D., Hsairi, M., Htet, A., Hu, G., Huang, J., Husseini, A., Hutchings, S., Huybrechts, I., Iburg, K., Idrisov, B., Ileanu, B., Inoue, M., Jacobs, T., Jacobsen, K., Jahanmehr, N., Jakovljevic, M., Jansen, H., Jassal, S., Javanbakht, M., Jayatilleke, A., Jee, S., Jeemon, P., Jha, V., Jiang, Y., Jibat, T., Jin, Y., Johnson, C., Jonas, J., Kabir, Z., Kalkonde, Y., Kamal, R., Kan, H., Karch, A., Karema, C., Karimkhani, C., Kasaeian, A., Kaul, A., Kawakami, N., Kazi, D., Keiyoro, P., Kemp, A., Kengne, A., Keren, A., Kesavachandran, C., Khader, Y., Khan, A., Khan, E., Khan, G., Khang, Y., Khatibzadeh, S., Khera, S., Khoja, T., Khubchandani, J., Kieling, C., Kim, C., Kim, D., Kimokoti, R., Kissoon, N., Kivipelto, M., Knibbs, L., Kokubo, Y., Kopec, J., Koul, P., Koyanagi, A., Kravchenko, M., Kromhout, H., Krueger, H., Ku, T., Defo, B., Kuchenbecker, R., Bicer, B., Kuipers, E., Kumar, G., Kwan, G., Lal, D., Lalloo, R., Lallukka, T., Lan, Q., Larsson, A., Latif, A., Beatriz Lawrynowicz, A., Leasher, J., Leigh, J., Leung, J., Levi, M., Li, X., Li, Y., Liang, J., Liu, S., Lloyd, B., Logroscino, G., Lotufo, P., Lunevicius, R., Maclntyre, M., Mahdavi, M., Majdan, M., Majeed, A., Malekzadeh, R., Malta, D., Manamo, W., Mapoma, C., Marcenes, W., Martin, R., Martinez-Raga, J., Masiye, F., Matsushita, K., Matzopoulos, R., Mayosi, B., McGrath, J., McKee, M., Meaney, P., Medina, C., Mehari, A., Mena-Rodriguez, F., Mekonnen, A., Melaku, Y., Memish, Z., Mendoza, W., Mensink, G., Meretoja, A., Meretoja, T., Mesfin, Y., Mhimbira, F., Miller, Ted, Mills, E., Mirarefin, M., Misganaw, A., Mock, C., Mohammadi, A., Mohammed, S., Mola, G., Monasta, L., Montanez Hernandez, J., Montico, M., Morawska, L., Mori, R., Mozaffarian, D., Mueller, U., Mullany, E., Mumford, J., Murthy, G., Nachega, J., Naheed, A., Nangia, V., Nassiri, N., Newton, J., Ng, M., Quyen, L., Nisar, M., Pete, P., Norheim, O., Norman, R., Norrving, B., Nyakarahuka, L., Obermeyer, C., Ogbo, F., Oh, I., Oladimeji, O., Olivares, P., Olsen, H., Olusanya, B., Olusanya, J., Opio, J., Oren, E., Orozco, R., Ortiz, A., Ota, E., Mahesh, P., Pana, A., Park, E., Parry, C., Parsaeian, M., Patel, T., Caicedo, A., Patil, S., Patten, S., Patton, G., Pearce, N., Pereira, D., Perico, N., Pesudovs, K., Petzold, M., Phillips, M., Piel, F., Pillay, J., Plass, D., Polinder, S., Pond, C., Pope, C., Pope, D., Popova, S., Poulton, R., Pourmalek, F., Prasad, N., Qorbani, M., Rabiee, R., Radfar, A., Rafay, A., Rahimi-Movaghar, V., Rahman, M., Rahman, S., Rai, R., Rajsic, S., Raju, M., Ram, U., Rana, S., Ranganathan, K., Rao, P., Razo Garcia, C., Refaat, A., Rehm, C., Rehm, J., Reinig, N., Remuzzi, G., Resnikoff, S., Ribeiro, A., Rivera, J., Rolm, H., Rodriguez, A., Rodriguez-Ramirez, S., Rojas-Rueda, D., Roman, Y., Ronfani, L., Roshandel, G., Rothenbacher, D., Roy, A., Saleh, M., Sanabria, J., Dolores Sanchez-Nino, M., Sanchez-Pimienta, T., Sandar, L., Santomauro, D., Santos, I., Sarmiento-Suarez, R., Sartorius, B., Satpathy, M., Savic, M., Sawhney, M., Schmidhuber, J., Schmidt, M., Schneider, I., Schoettker, B., Schutte, A., Schwebel, D., Scott, J., Seedat, S., Sepanlou, S., Servan-Mori, E., Shaheen, A., Shahraz, S., Shaikh, M., Levy, T., Sharma, R., She, J., Sheikhbahaei, S., Shen, J., Sheth, K., Shi, P., Shibuya, K., Shigematsu, M., Shin, M., Shiri, R., Shishani, K., Shiue, I., Shrime, M., Sigfusdottir, I., Silva, D., Alves Silveira, D., Silverberg, J., Simard, E., Sindi, S., Singh, A., Singh, J., Singh, P., Slepak, E., Soljak, M., Soneji, S., Sorensen, R., Sposato, L., Sreeramareddy, C., Stathopoulou, V., Steckling, N., Steel, N., Stein, D., Stein, M., Stockl, H., Stranges, S., Stroumpoulis, K., Sunguya, B., Swaminathan, S., Sykes, B., Szoeke, C., Tabares-Seisdedos, R., Takahashi, K., Talongwa, R., Landon, N., Tanne, D., Tavakkoli, M., Taye, B., Taylor, H., Tedla, B., Tefera, W., Tegegne, T., Tekle, D., Terkawi, A., Thakur, J., Thomas, B., Thomas, M., Thomson, A., Thorne-Lyman, A., Thrift, A., Thurston, G., Tillmann, T., Tobe-Gai, R., Tobollik, M., Topor-Madry, R., Topouzis, F., Towbin, J., Bach, X., Dimbuene, Z., Tsilimparis, N., Tura, A., Tuzcu, E., Tyrovolas, S., Ukwaja, K., Undurraga, E., Uneke, C., Uthman, O., van Donkelaar, A., van Os, J., Varakin, Y., Vasankari, T., Veerman, J., Venketasubramanian, N., Violante, F., Vollset, S., Wagner, G., Waller, S., Wang, J., Wang, L., Wang, Y., Weichenthal, S., Weiderpass, E., Weintraub, R., Werdecker, A., Westerman, R., Whiteford, H., Wijeratne, T., Wiysonge, C., Wolfe, C., Won, S., Woolf, A., Wubshet, M., Xavier, D., Xu, G., Yadav, A., Yakob, B., Yalew, A., Yano, Y., Yaseri, M., Ye, P., Yip, P., Yonemoto, N., Yoon, S., Younis, M., Yu, C., Zaidi, Z., Zaki, M., Zhu, J., Zipkin, B., Zodpey, S., Zuhlke, L., and Murray, C.
- Published
- 2016
42. Effects of Odanacatib on the Radius and Tibia of Postmenopausal Women:Improvements in Bone Geometry, Microarchitecture and Estimated Bone Strength
- Author
-
Cheung, Am, Majumdar, S, Brixen, K, Chapurlat, R, Fuerst, T, Engelke, K, Dardzinski, B, Cabal, A, Verbruggen, N, Ather, S, Rosenberg, E, and de Papp, Ae
- Subjects
musculoskeletal diseases ,Compressive Strength ,Bone and Bones/drug effects ,Tibia/drug effects ,Volumetric BMD ,Middle Aged ,Reference Standards ,Bone Remodeling/drug effects ,Osteoporosis ,Humans ,Biphenyl Compounds/pharmacology ,Female ,Radius/drug effects ,Odanacatib ,Aged - Abstract
The cathepsin K inhibitor odanacatib (ODN), currently in phase 3 development for postmenopausal osteoporosis, has a novel mechanism of action that reduces bone resorption while maintaining bone formation. In phase 2 studies, odanacatib increased areal bone mineral density (aBMD) at the lumbar spine and total hip progressively over 5 years. To determine the effects of ODN on cortical and trabecular bone and estimate changes in bone strength, we conducted a randomized, double-blind, placebo-controlled trial, using both quantitative computed tomography (QCT) and high-resolution peripheral (HR-p)QCT. In previously published results, odanacatib was superior to placebo with respect to increases in trabecular volumetric BMD (vBMD) and estimated compressive strength at the spine, and integral and trabecular vBMD and estimated strength at the hip. Here, we report the results of HR-pQCT assessment. A total of 214 postmenopausal women (mean age 64.0±6.8 years and baseline lumbar spine T-score -1.81±0.83) were randomized to oral ODN 50mg or placebo, weekly for 2 years. With ODN, significant increases from baseline in total vBMD occurred at the distal radius and tibia. Treatment differences from placebo were also significant (3.84% and 2.63% for radius and tibia, respectively). At both sites, significant differences from placebo were also found in trabecular vBMD, cortical vBMD, cortical thickness, cortical area, and strength (failure load) estimated using finite element analysis of HR-pQCT scans (treatment differences at radius and tibia=2.64% and 2.66%). At the distal radius, odanacatib significantly improved trabecular thickness and bone volume/total volume (BV/TV) versus placebo. At a more proximal radial site, odanacatib attenuated the increase in cortical porosity found with placebo (treatment difference=-7.7%, p=0.066). At the distal tibia, odanacatib significantly improved trabecular number, separation, and BV/TV versus placebo. Safety and tolerability were similar between treatment groups. In conclusion, odanacatib increased cortical and trabecular density, cortical thickness, aspects of trabecular microarchitecture, and estimated strength at the distal radius and distal tibia compared with placebo.
- Published
- 2014
43. Quantitative ultrasound of the tibia: A risk assessment of vertebral fractures?
- Author
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Uffmann, M., Fan, B., Fuerst, T. P., Li, J., and Genant, H. K.
- Published
- 1996
- Full Text
- View/download PDF
44. Survival tree analysis for fracture risk
- Author
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Lu, Y., Mathur, A., Black, D., Fuerst, T., Genant, H. K., and SOF Research Group
- Published
- 1996
- Full Text
- View/download PDF
45. Role of MXA in screening osteoporosis patients for vertebral fracture
- Author
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Li, J., Fuerst, T., Lu, Y., and Genant, H. K.
- Published
- 1996
- Full Text
- View/download PDF
46. Evaluation of body composition and total body bone mass with the hologic QDR-4500
- Author
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Fuerst, T. and Genant, H. K.
- Published
- 1996
- Full Text
- View/download PDF
47. Cortical and trabecular bone: A comparison of QUS and BMD in postmenopausal women with osteoporosis
- Author
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Fan, B., Uffmann, M., Fuerst, T. P., Li, J., Lu, Y., and Genant, H. K.
- Published
- 1996
- Full Text
- View/download PDF
48. Nevitt M for the Health, Aging and Body Composition Study. Waist circumference and sagittal diameter reflect total body fat better than visceral fat in older men and women: The Health, Aging and Body Composition Study
- Author
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Harris, T.B., Visser, M., Everhart, J., Cauley, J., Tylavsky, F., Fuerst, T., Zamboni, M., Taaffe, D., Resnick, H., Scherzinger, A., EMGO+ - Musculoskeletal Health, EMGO+ - Lifestyle, Overweight and Diabetes, and EMGO+ - Quality of Care
- Published
- 2000
49. SAT0222 Effects of Tofacitinib on MRI Endpoints in Methotrexate-Naive Early Rheumatoid Arthritis: A Phase 2 MRI Study with Semi-Quantitative and Quantitative Endpoints
- Author
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Conaghan, P.G., primary, Østergaard, M., additional, Bowes, M.A., additional, Wu, C., additional, Fuerst, T., additional, van der Heijde, D., additional, Hrycaj, P., additional, Xie, Z., additional, Zhang, R., additional, Wyman, B.T., additional, Bradley, J., additional, Soma, K., additional, and Wilkinson, B., additional
- Published
- 2015
- Full Text
- View/download PDF
50. Serum dioxin concentrations and bone density and structure in the Seveso Women's Health Study
- Author
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Eskenazi, B, Warner, M, Sirtori, M, Fuerst, T, Rauch, S, Brambilla, P, Mocarelli, P, Rubinacci, A, BRAMBILLA, PAOLO, MOCARELLI, PAOLO, Rubinacci, A., Eskenazi, B, Warner, M, Sirtori, M, Fuerst, T, Rauch, S, Brambilla, P, Mocarelli, P, Rubinacci, A, BRAMBILLA, PAOLO, MOCARELLI, PAOLO, and Rubinacci, A.
- Abstract
Background: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), a widespread environmental contaminant, is a known endocrine disruptor. In animal studies, TCDD exposure impairs bone metabolism and increases fragility. To our knowledge, no epidemiologic studies have examined this association. Objectives: On 10 July 1976, a chemical explosion in Seveso, Italy, resulted in the highest known residential exposure to TCDD. In 1996, we initiated the Seveso Women's Health Study, a retrospective cohort study of the health of the women. In 2008, we followed up the cohort. Here, we evaluated the association between TCDD exposure and bone structure and geometry in adulthood, and considered whether timing of TCDD exposure before achievement of peak bone mass (assumed to occur 2 years after onset of menarche) modified the association. Methods: Individual TCDD concentration was measured in archived serum collected soon after the explosion. In 2008, 350 women who were < 20 years old in 1976 underwent a dual-energy X-ray absorptiometry (DXA) bone scan. Bone mineral density was measured at the lumbar spine and hip, and hip geometry was extracted from hip DXA scans using the hip structural analysis method. Results: Among premenopausal women, TCDD serum levels were associated with some indexes indicating better bone structure in women exposed before peak bone mass (n = 219), with stronger associations in those exposed before 5 years of age (n = 46). In contrast, among postmenopausal women, TCDD levels were associated with evidence of better bone structure in women exposed after peak bone mass (n = 48) than in other women (n = 18). Conclusions: Our current results do not support the hypothesis that postnatal TCDD exposure adversely affects adult bone health. Continued follow-up of women who were youngest at exposure is warranted. Future studies should also focus on those exposed in utero.
- Published
- 2014
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