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2. Temporal and spatial patterns of Trichuris trichiura eggs: a potential threat to human health in Pakistan

Author

Ali S. A., Niaz S., Nasreen N., Khan A., Shafeeq S., Aguilar-Marcelino L., Safi W. A., Zaki M. A., De La Fuente J., and Ben Said M.

Subjects
trichuriasis, trichuris trichiura eggs, contaminated soil, prevalence, spatio-temporal assessment, pakistan, Microbiology, QR1-502
Abstract

This study investigates the presence of Trichuris trichiura eggs in soil samples collected from urban areas in Lahore, Pakistan. A total of 3600 soil samples were collected over two years from Lahore’s urban regions. The detection of helminth eggs in these samples was performed using sodium hypochlorite (NaOCl) as a diagnostic technique. The study reveals an overall prevalence rate of T. trichiura at 0.97 % (35 out of 3600) in the contaminated soil samples from Lahore’s slum areas. When analyzing the data by geographical areas, the study found the highest prevalence of T. trichiura in Allama Iqbal Town (1.83 %, 11 out of 600), followed by Samanabad (1.16 %, 7 out of 600), Wapda Town (1.00 %, 6 out of 600), Gulberg (1.00 %, 6 out of 600), and Cantt (0.50 %, 3 out of 600). Conversely, Valencia Town had the lowest prevalence rate at 0.33 % (2 out of 600). However, these variations in prevalence rates were not statistically significant (p = 0.117). Prevalence rates of T. trichiura’s eggs varied significantly across different sampling seasons (p>0.001). In autumn, a total of 900 soil samples were collected, with 19 samples (2.11 %) testing positive for T. trichiura. This rate was notably higher compared to the prevalence rates observed in winter, spring, and summer, which were 0.66 %, 0.22 %, and 0.88 %, respectively. Regarding the sampling months, the study observed a significantly higher prevalence during September (3.33 %, 10 out of 300), followed by October (2.33 %, 7 out of 300), and August (1.33 %, 4 out of 300). Prevalence rates gradually decreased in other months, ranging from 1 % to 0.33 % (3 to 1 out of 300), with no parasite detection in March (0 %, 0 out of 300) (p < 0.001). This research underscores soil contamination due to fecal waste and highlights public unawareness of parasite biology, driven by open defecation practices.

Published
2024
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4. The CARMENES search for exoplanets around M dwarfs. Two temperate Earth-mass planet candidates around Teegarden's Star

Author

Zechmeister, M., Dreizler, S., Ribas, I., Reiners, A., Caballero, J. A., Bauer, F. F., Béjar, V. J. S., González-Cuesta, L., Herrero, E., Lalitha, S., López-González, M. J., Luque, R., Morales, J. C., Pallé, E., Rodríguez, E., López, C. Rodríguez, Tal-Or, L., Anglada-Escudé, G., Quirrenbach, A., Amado, P. J., Abril, M., Aceituno, F. J., Aceituno, J., Alonso-Floriano, F. J., Eiff, M. Ammler-von, Jiménez, R. Antona, Anwand-Heerwart, H., Arroyo-Torres, B., Azzaro, M., Baroch, D., Barrado, D., Becerril, S., Benítez, D., Berdiñas, Z. M., Bergond, G., Bluhm, P., Brinkmöller, M., del Burgo, C., Ortega, R. Calvo, Cano, J., Guillén, C. Cardona, Carro, J., Vázquez, M. C. Cárdenas, Casal, E., Casasayas-Barris, N., Casanova, V., Chaturvedi, P., Cifuentes, C., Claret, A., Colomé, J., Cortés-Contreras, M., Czesla, S., Díez-Alonso, E., Dorda, R., Fernández, M., Fernández-Martín, A., Ferro, I. M., Fuhrmeister, B., Fukui, A., Galadí-Enríquez, D., Cava, I. Gallardo, de la Fuente, J. Garcia, Garcia-Piquer, A., Vargas, M. L. García, Gesa, L., Rueda, J. Góngora, González-Álvarez, E., Hernández, J. I. González, González-Peinado, R., Grözinger, U., Guàrdia, J., Guijarro, A., de Guindos, E., Hatzes, A. P., Hauschildt, P. H., Hedrosa, R. P., Helmling, J., Henning, T., Hermelo, I., Arabi, R. Hernández, Castaño, L. Hernández, Otero, F. Hernández, Hintz, D., Huke, P., Huber, A., Jeffers, S. V., Johnson, E. N., de Juan, E., Kaminski, A., Kemmer, J., Kim, M., Klahr, H., Klein, R., Klüter, J., Klutsch, A., Kossakowski, D., Kürster, M., Labarga, F., Lafarga, M., Llamas, M., Lampón, M., Lara, L. M., Launhardt, R., Lázaro, F. J., Lodieu, N., del Fresno, M. López, López-Comazzi, A., López-Puertas, M., Salas, J. F. López, López-Santiago, J., Madinabeitia, H. Magán, Mall, U., Mancini, L., Mandel, H., Marfil, E., Molina, J. A. Marín, Fernández, D. Maroto, Martín, E. L., Martín-Fernández, P., Martín-Ruiz, S., Marvin, C. J., Mirabet, E., Montañés-Rodríguez, P., Montes, D., Moreno-Raya, M. E., Nagel, E., Naranjo, V., Narita, N., Nortmann, L., Nowak, G., Ofir, A., Oshagh, M., Panduro, J., Parviainen, H., Pascual, J., Passegger, V. M., Pavlov, A., Pedraz, S., Pérez-Calpena, A., Medialdea, D. Pérez, Perger, M., Perryman, M. A. C., Rabaza, O., Ballesta, A. Ramón, Rebolo, R., Redondo, P., Reffert, S., Reinhardt, S., Rhode, P., Rix, H. -W., Rodler, F., Trinidad, A. Rodríguez, Rosich, A., Sadegi, S., Sánchez-Blanco, E., Carrasco, M. A. Sánchez, Sánchez-López, A., Sanz-Forcada, J., Sarkis, P., Sarmiento, L. F., Schäfer, S., Schmitt, J. H. M. M., Schöfer, P., Schweitzer, A., Seifert, W., Shulyak, D., Solano, E., Sota, A., Stahl, O., Stock, S., Strachan, J. B. P., Stuber, T., Stürmer, J., Suárez, J. C., Tabernero, H. M., Pinto, M. Tala, Trifonov, T., Veredas, G., Linares, J. I. Vico, Vilardell, F., Wagner, K., Wolthoff, V., Xu, W., Yan, F., and Osorio, M. R. Zapatero

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

Context. Teegarden's Star is the brightest and one of the nearest ultra-cool dwarfs in the solar neighbourhood. For its late spectral type (M7.0V), the star shows relatively little activity and is a prime target for near-infrared radial velocity surveys such as CARMENES. Aims. As part of the CARMENES search for exoplanets around M dwarfs, we obtained more than 200 radial-velocity measurements of Teegarden's Star and analysed them for planetary signals. Methods. We find periodic variability in the radial velocities of Teegarden's Star. We also studied photometric measurements to rule out stellar brightness variations mimicking planetary signals. Results. We find evidence for two planet candidates, each with $1.1M_\oplus$ minimum mass, orbiting at periods of 4.91 and 11.4 d, respectively. No evidence for planetary transits could be found in archival and follow-up photometry. Small photometric variability is suggestive of slow rotation and old age. Conclusions. The two planets are among the lowest-mass planets discovered so far, and they are the first Earth-mass planets around an ultra-cool dwarf for which the masses have been determined using radial velocities., Comment: A&A 627, A49. 26 pages, 17 figures, 6 tables. Press release available at http://www.astro.physik.uni-goettingen.de/~zechmeister/teegarden/teegarden.html. v2: two authors and one reference added

Published
2019
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5. Busulfan–fludarabine- or treosulfan–fludarabine-based conditioning before allogeneic HSCT from matched sibling donors in paediatric patients with sickle cell disease: A study on behalf of the EBMT Paediatric Diseases and Inborn Errors Working Parties

Author

Cseh, A, Galimard, J, de la Fuente, J, Isgro, A, Zecca, M, Garwer, B, Biffi, A, Aljurf, M, Sundin, M, Belendez, C, Locatelli, F, Balduzzi, A, Lawson, S, Sengeloev, H, Ifversen, M, Saccardi, R, Wynn, R, Lankester, A, Corbacioglu, S, Peters, C, Cseh A., Galimard J. -E., de la Fuente J., Isgro A., Zecca M., Garwer B., Biffi A., Aljurf M., Sundin M., Belendez C., Locatelli F., Balduzzi A., Lawson S., Sengeloev H., Ifversen M., Saccardi R., Wynn R., Lankester A. C., Corbacioglu S., Peters C., Cseh, A, Galimard, J, de la Fuente, J, Isgro, A, Zecca, M, Garwer, B, Biffi, A, Aljurf, M, Sundin, M, Belendez, C, Locatelli, F, Balduzzi, A, Lawson, S, Sengeloev, H, Ifversen, M, Saccardi, R, Wynn, R, Lankester, A, Corbacioglu, S, Peters, C, Cseh A., Galimard J. -E., de la Fuente J., Isgro A., Zecca M., Garwer B., Biffi A., Aljurf M., Sundin M., Belendez C., Locatelli F., Balduzzi A., Lawson S., Sengeloev H., Ifversen M., Saccardi R., Wynn R., Lankester A. C., Corbacioglu S., and Peters C.

Published
2024

6. Current and Future Strategies for the Diagnosis and Treatment of the Alpha-Gal Syndrome (AGS)

Author

Vaz-Rodrigues R, Mazuecos L, and de la Fuente J

Subjects
alpha-gal syndrome (ags), food allergy, alpha-gal, glycan, tick, ige, Immunologic diseases. Allergy, RC581-607
Abstract

Rita Vaz-Rodrigues,1 Lorena Mazuecos,1 José de la Fuente1,2 1SaBio (Health and Biotechnology), Instituto de Investigación en Recursos Cinegéticos IREC (CSIC-UCLM-JCCM), Ciudad Real, 13005, Spain; 2Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK, 74078, USACorrespondence: José de la Fuente, SaBio (Health and Biotechnology), Instituto de Investigación en Recursos Cinegéticos IREC (CSIC-UCLM-JCCM), Ronda de Toledo s/n, Ciudad Real, 13005, Spain, Tel +34 926 295 151, Email jose_delafuente@yahoo.comAbstract: The α-Gal syndrome (AGS) is a pathognomonic immunoglobulin E (IgE)-mediated delayed anaphylaxis in foods containing the oligosaccharide galactose-α-1,3-galactose (α-Gal) such as mammalian meat or dairy products. Clinical presentation of AGS can also comprise immediate hypersensitivity due to anticancer therapy, gelatin-containing vaccines or mammalian serum-based antivenom. The IgE initial sensitization is caused by hard-bodied tick bites and symptomatic individuals typically develop delayed pruritus, urticaria, angioedema, anaphylaxis, malaise or gut-related symptoms. Due to inapparent presentation, delayed reactions and a wide variety of patients´ clinical history, the AGS diagnosis and treatment remain challenging. This review covers not only current diagnostic methods used for AGS such as the skin prick test (SPT), the oral food challenge (OFC), anti-α-Gal IgE levels measurement and the basophil activation test (BAT), but also potentially relevant next-generation diagnostic tools like the mast cell activation test (MAT), the histamine-release (HR) assay, omics technologies and model-based reasoning (MBR). Moreover, it focuses on the therapeutical medical and non-medical methods available and current research methods that are being applied in order to elucidate the molecular, physiological and immune mechanisms underlying this allergic disorder. Lastly, future treatment and preventive tools are also discussed, being of utmost importance for the identification of tick salivary molecules, with or without α-Gal modifications, that trigger IgE sensitivity as they could be the key for further vaccine development. Bearing in mind climate change, the tick-host paradigm will shift towards an increasing number of AGS cases in new regions worldwide, which will pose new challenges for clinicians in the future.Keywords: alpha-Gal syndrome, AGS, food allergy, alpha-Gal, glycan, tick, IgE

Published
2022

9. Use of Rheology as a Tool for Interfacial Characterisation of Silkworm Pupae (Bombyx mori) Protein Concentrate Adsorbed at A/W Interface

Author

Bascon, C., Felix, M., Pérez-Puyana, V., de la Fuente, J., Ghosh, Arindam, Series Editor, Chua, Daniel, Series Editor, de Souza, Flavio Leandro, Series Editor, Aktas, Oral Cenk, Series Editor, Han, Yafang, Series Editor, Gong, Jianghong, Series Editor, Galindo-Rosales, Francisco José, editor, Campo-Deaño, Laura, editor, Afonso, Alexandre M., editor, Alves, Manuel A., editor, and Pinho, Fernando T., editor

Published
2020
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11. Resultado de la implantación de consultas telemáticas en cirugía ortopédica y traumatología durante la pandemia COVID-19

Author

Zamora Navas, P., Montañez Heredia, E., Nieto Orellana, J., Gónzalez García, C., Cano Obando, L., Cárdenas Rebollo, L., Abderrachid Al Chaid, Y., Saadouli Arco, M., Rodríguez Delourme, I., Díez Izquierdo, M., Prado Martín de Lucía, L.F., Durán Garrido, J., Fernández Hijano, M., Víquez da Silva, R., Olofsson Suárez-Bárcena, C., Jiménez Garrido, C., García Vera, J.J., Pérez Cardeña, J., Irízar Jiménez, S., Esteban del Castillo, J.L., García Píriz, M., Gómez Palomo, J.M., Fernández Martín, F.J.A., Huertas Segador, P., Santos de la Fuente, J., Serrano Fernández, J., Estades Rubio, F., Fernández de Rota, A., García Herrera, J.M., Leiva Gea, A., Lombardo Torre, M., Mariscal Lara, J., Martín Castilla, B., Urbano Labajos, V., Sánchez García, A., Quirante Sánchez, V., Cañada Oya, S., Rodríguez Jiménez, M., Delgado Rufino, B., Queipo de Llano Temboury, A., Barón Romero, M., López Hermoso, M.D., Benavente Casajús, M., Loring Caffarena, T., Chaparro Villar, M.A., and de la Torre Solís, F.

Published
2021
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12. Efecto del enriquecimiento ambiental alimenticio en el comportamiento de ovejas alojadas en estabulación permanente

Author

Gonçalves-Casaco, J. T. V., Fuente, J. de la, Pérez Marcos, Concepción, González De Chávarri Echániz, Elisabeth, Gonçalves-Casaco, J. T. V., Fuente, J. de la, Pérez Marcos, Concepción, and González De Chávarri Echániz, Elisabeth

Abstract

La creciente preocupación por el bienestar de los animales en sistemas de producción intensivos ha llevado al desarrollo de diferentes programas de enriquecimiento ambiental, para mejorar el grado de diversidad comportamental de los animales de granja y mejorar su bienestar. El objetivo de este trabajo fue determinar los efectos de un enriquecimiento ambiental alimenticio sobre la respuesta comportamental de ovejas gestantes, lactantes con corderos y secas. A partir del rebaño de la Facultad de Veterinaria de la Universidad Complutense de Madrid, 36 ovejas de la raza Castellana se distribuyeron aleatoriamente en 9 lotes de 4 ovejas, 3 grupos por estado fisiológico. El enriquecimiento nutricional consistió en proporcionar el 25 % de la ración de volumen, heno de alfalfa, en una malla suspendida del techo y una plataforma para facilitar el acceso, administrando también heno en el comedero habitual. Se grabaron las frecuencias y el tiempo que las ovejas dedicaron a la expresión de los distintos comportamientos. Las ovejas lactantes usaron de inmediato el enriquecimiento, mientras que las gestantes aprendieron, porque no fueron a comer a la malla el día 1, pero sí los días sucesivos. Al cuarto día la frecuencia y el tiempo que el conjunto de ovejas dedicó a comer en los diferentes sitios era mayor, así como las interacciones sociales en gestantes y secas, siendo menor el comportamiento de pie observando. Se ha conseguido que las ovejas se mantengan activas y distraídas, expresando durante más tiempo un repertorio de comportamientos naturales y, en consecuencia, mejorando su bienestar., Depto. de Producción Animal, Fac. de Veterinaria, TRUE, pub

Published
2024

25. CHARACTERIZATION OF TRANSCRIPTIONAL ALTERATIONS LEADING TO ABERRANT MYELOID DIFFERENTIATION IN MYELODYSPLASTIC SYNDROMES

Author

Diaz-Mazkiaran, A., primary, De La Fuente, J., additional, Serrano, G., additional, Ainciburu, M., additional, García-Olloqui, P., additional, Berastegui, N., additional, Alfonso, A., additional, Vilas-Zornoza, A., additional, San-Martin, P., additional, Lamo-Espinosa, J.M., additional, Julián, M. San, additional, Acha, P., additional, Solas, T. Jiménez, additional, López-Cadenas, F., additional, Molero, A., additional, Montoro, M.J., additional, Solé, F., additional, Diez-Campelo, M., additional, Valcárcel, D., additional, Prosper, F., additional, Hernaez, M., additional, and Ezponda, T., additional

Published
2023
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26. 5612617 EFFICACY AND SAFETY OF A SINGLE DOSE OF EXAGAMGLOGENE AUTOTEMCEL FOR TRANSFUSION-DEPENDENT-THALASSEMIA AND SEVERE SICKLE CELL DISEASE

Author

de la Fuente, J., primary, Locatelli, F., additional, Frangoul, H., additional, Corbacioglu, S., additional, Wall, D., additional, Cappellini, M., additional, de Montalembert, M., additional, Kattamis, A., additional, Lobitz, S., additional, Rondelli, D., additional, Sheth, S., additional, Steinberg, M., additional, Walters, M., additional, Bobruff, Y., additional, Simard, C., additional, Song, Y., additional, Zhang, L., additional, Sharma, A., additional, Imren, S., additional, Hobbs, B., additional, and Grupp, S., additional

Published
2023
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27. Development of biosensors for detection of SARS-CoV-2 virus by Triplex Enhanced Nucleic Acid Detection Assay (TENADA).

Author

Aviñó, Anna, Domínguez, A., Cuesta, C., Martínez de la Fuente, J., Grazu, V., Ciudad, C., Noé, V., Gargallo, Raimundo, Calderón, E., Fàbrega, Carme, Eritja Casadellà, Ramón, Aviñó, Anna, Domínguez, A., Cuesta, C., Martínez de la Fuente, J., Grazu, V., Ciudad, C., Noé, V., Gargallo, Raimundo, Calderón, E., Fàbrega, Carme, and Eritja Casadellà, Ramón

Abstract

SARS-CoV-2, a positive-strand RNA virus has caused devastating effects. The standard method for COVID diagnosis is based on polymerase chain reaction (PCR). The method needs expensive reagents and equipment and well-trained personnel and takes a few hours to be completed. The search for faster solutions has led to the development of immunological assays based on antibodies that recognize the viral proteins that are faster and do not require any special equipment. Here we explore an innovative analytical approach based on the sandwich oligonucleotide hybridization which can be adapted to several biosensing devices. PolyPurine Reverse Hoogsteen hairpins (PPRHs) oligonucleotides that form high affinity triplexes with the polypyrimidine target sequences are used for the efficient capture of the viral genome. Then, a second labelled oligonucleotide is used to detect the formation of a trimolecular complex in a similar way than antigen tests do. The limit of detection is around 0.01 nM (a few femtomoles) without the use of any amplification steps. The Triplex Enhanced Nucleic Acid Detection Assay (TENADA) can be readily adapted for the detection of any pathogen requiring only the knowledge of the pathogen genome sequence.

Published
2023

28. Busulfan–fludarabine- or treosulfan–fludarabine-based conditioning before allogeneic HSCT from matched sibling donors in paediatric patients with sickle cell disease: A study on behalf of the EBMT Paediatric Diseases and Inborn Errors Working Parties

Author

Cseh, A., Galimard, J. -E., de la Fuente, J., Isgro, A., Zecca, M., Garwer, B., Biffi, A., Aljurf, M., Sundin, M., Belendez, C., Locatelli, Franco, Balduzzi, A., Lawson, S., Sengeloev, H., Ifversen, M., Saccardi, R., Wynn, R., Lankester, A. C., Corbacioglu, S., Peters, C., Locatelli F. (ORCID:0000-0002-7976-3654), Cseh, A., Galimard, J. -E., de la Fuente, J., Isgro, A., Zecca, M., Garwer, B., Biffi, A., Aljurf, M., Sundin, M., Belendez, C., Locatelli, Franco, Balduzzi, A., Lawson, S., Sengeloev, H., Ifversen, M., Saccardi, R., Wynn, R., Lankester, A. C., Corbacioglu, S., Peters, C., and Locatelli F. (ORCID:0000-0002-7976-3654)

Abstract

How important is choice of conditioning regimen in allogeneic haematopoietic stem cell transplantation (HSCT) for sickle cell disease (SCD)? We compared HSCT outcomes by conditioning regimen in paediatric patients with SCD from the EBMT registry. In 2010-2020, 251 patients aged <18 years underwent a first matched sibling donor (MSD) HSCT with conditioning based on busulfan-fludarabine (bu-flu; n = 89) or treosulfan-fludarabine (treo-flu; n = 162). In the bu-flu and treo-flu groups, 51.7% and 99.4% of patients, respectively, received thiotepa. Median follow-up was 2.7 years. Two-year overall survival (OS) was 98.7% (95% confidence interval [CI]: 90.9-99.8) with bu-flu and 99.3% (95% CI: 95.2-99.9) with treo-flu (p = 0.63). Grade III-IV acute graft-versus-host disease (GVHD) at 100 days was 2.4% (95% CI: 0.4-7.5) and 0.6% (0.1%-3.2%) for bu-flu and treo-flu respectively (p = 0.25). The 2-year incidence of extensive chronic GVHD was 1.5% (95% CI: 0.1-7.3) with bu-flu and 8.0% (95% CI: 4.1-13.3) with treo-flu (p = 0.057). These multinational data confirm the excellent curative capacity of MSD HSCT with myeloablative conditioning. Both conditioning regimens yielded excellent OS, low rates of acute and chronic GVHD, and low rates of graft failure.

Published
2023

30. Low NETosis Induced in Anaplasma phagocytophilum-Infected Cells

Author

Artigas-Jerónimo S, González-García A, de la Fuente J, Blanda V, Shekarkar Azgomi M, Villar M, Mohammadnezhad L, Grippi F, Torina A, Sireci G., and Artigas-Jerónimo S, González-García A, de la Fuente J, Blanda V, Shekarkar Azgomi M, Villar M, Mohammadnezhad L, Grippi F, Torina A, Sireci G.

Subjects
Neutrophils, NETOSIS, Anaplasma Phagocitophylum, ROS
Abstract

Anaplasma phagocytophilum are obligatory intracellular bacteria that preferentially replicate inside leukocytes by utilizing biological compounds and processes of these primary host defensive cells. In this study, bioinformatics analysis was conducted to further characterize A. phagocytophilum– host interactions using the neutrophil-like model of human Caucasian promyelocytic leukemia HL60 cells. We detected a hierarchy of molecules involved in A. phagocytophilum-HL60 interactions with overrepresentation in infected human cells of proteins involved in the reactive oxygen species (ROS) pathway and cell surface monocyte markers. As A. phagocytophilum phagocytosis by neutrophils is inhibited, the results suggested a possible explanation for our bioinformatics data: radical oxygen compounds could induce the killing of bacteria activating NETosis, a unique form of defense mechanism resulting in cell death that is characterized by the release of decondensed chromatin and granular contents to the extracellular space, forming neutrophil extracellular traps (NETs) to eliminate invading microorganisms. Thus, we confirmed the existence of a low NETosis induced in A. phagocytophilum- infected cells by immunofluorescence (IF) experiments. These results provide new insights into the complex mechanisms that govern immune response during A. phagocytophilum host interactions.

Published
2022

32. Study for the evaluation of the processes of reuse and recycling of reverse osmosis components and membranes in the Canary Islands and Macaronesia.

Author

León Zerpa, Federico, Peñate Suárez, Baltasar, Roo Filgueira, Javier, De La Fuente, J. A., Ramos Martín, Alejandro, and Tavares, Tomas

Subjects
REVERSE osmosis, REVERSE osmosis process (Sewage purification), WASTE recycling, GAS as fuel, PLASTIC scrap, PLANT membranes
Abstract

This technical report is based on the study for the evaluation of the processes of reuse and recycling of reverse osmosis components and membranes in the Canary Islands and Macaronesia, within the DESAL+ project and in the framework of the DESAL+ LIVING LAB platform, coordinated by the Canary Islands Technological Institute (ITC) and the Canary Islands Agency for Research, Innovation and Information Society (ACIISI), with the support of the Interreg-MAC Programme. Reverse osmosis membranes could be reused in the same or another desalination plant by replacing the membranes in the first, dirtier positions with those in the last, less damaged positions. Also, by changing the best first-stage membranes to the second and vice versa, the useful life of these membranes could be extended through chemical cleaning and a second life could be given in tertiary treatment plants, reuse in industrial processes where they use special reverse osmosis membranes and degrade rapidly, in processes with leachate from landfill waste and also an interesting option is the oxidation of reverse osmosis elements to obtain nanofiltration, ultrafiltration or microfiltration membranes for the removal of physical dirt. The main categories of thermal processing recycling commonly used in industry include incineration and pyrolysis to produce energy, gas and fuel. These processes can be applied to mixed plastic waste, such as the combination of materials used in the manufacture of reverse osmosis membranes. The recycling of reverse osmosis elements from desalination plants is shown as an opportunity, nowadays existing pioneering initiatives in Europe. Energy recovery, via incineration, is feasible but is not considered in accordance with the environmental, social and political problems that this may generate. However, the recycling of the reverse osmosis elements via pyrolytic industry for fuel production can be centralized in a new industry already planned in the Canary Islands and all the osmosis membranes that are obsolete can be sent there. This is a technically and economically viable business opportunity with a promising future in today's recycling market as studied in the technical report. [ABSTRACT FROM AUTHOR]

Published
2023
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33. Recent progress on catalyst technologies for high quality gasoline production.

Author

Velázquez, Heriberto Díaz, Cerón-Camacho, Ricardo, Mosqueira-Mondragón, M. Lourdes, Hernández-Cortez, J. G., Montoya de la Fuente, J. A., Hernández-Pichardo, M.L., Beltrán-Oviedo, Tomás A., and Martínez-Palou, Rafael

Subjects
ANTIKNOCK gasoline, PETROLEUM refining, GASOLINE, FISCHER-Tropsch process, ALTERNATIVE fuels, FUEL quality
Abstract

The growing demand for clean and efficient fuels in the world reflects the rapid growth in automotive vehicles and more stringent environmental regulations. Hence, the refining industry must employ diverse strategies to obtain a gasoline pool made up of streams from different processes focused on improving the fuel quality and the octane ratings suitable for the current demanding automotive performance. The composition of gasoline varies mainly from each country's policies, climate, environmental regulations, financial capacity, and local producer's oil refining infrastructure. However, a generally accepted composition by source of the gasoline pool is: FCC naphtha and reformate, making up about 60%, light straight-run naphtha and alkylate gasoline, around 30%, isomerate, close to 5%, and variable proportions of butane, oxygenating agents, such as methyl-ter-butyl ether (MTBE), ter-amyl-methyl ether (TAME) and/or ethanol and additives for the remaining 5%. This review is focused on the recent research in the advancement and development of catalysts for the different processes used by the oil refining industry to improve the composition and properties of gasoline fuels. A detailed section on the Fischer-Tropsch process, where liquid hydrocarbons are potentially employed to further produce clean gasoline, is also discussed. A section devoted to research on biogasoline as a potential renewable fuel is also addressed. Finally, a discussion of the physicochemical properties of the gasoline blending components is also provided. [ABSTRACT FROM AUTHOR]

Published
2023
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37. Busulfan–fludarabine- or treosulfan–fludarabine-based myeloablative conditioning for children with thalassemia major

Author

Luftinger, R., Zubarovskaya, N., Galimard, J.E., Cseh, A., Salzer, E., Locatelli, F., Algeri, M., Yesilipek, A., Fuente, J. de la, Isgro, A., Alseraihy, A., Angelucci, E., Smiers, F.J., Nasa, G.L., Zecca, M., Fisgin, T., Unal, E., Kleinschmidt, K., Peters, C., Lankester, A., and Corbacioglu, S.

Subjects
Male, Transplantation Conditioning, Adolescent, Treosulfan, beta-Thalassemia, Infant, Antineoplastic Agents, Hematopoietic stem cell transplantation, Hematology, General Medicine, Myeloablative Agonists, Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA, Child, Preschool, Humans, Female, Child, Thalassemia major, Busulfan, Immunosuppressive Agents, Vidarabine, Retrospective Studies, Conditioning
Abstract

Significant advances in supportive care for patients with transfusion-dependent thalassemia major (TDT) have improved patients' life expectancy. However, transfusion-associated iron overload remains a significant barrier to long-term survival with good quality of life. Today, allogeneic hematopoietic stem cell transplantation (HSCT) is the current curative standard of care. Alongside selection of the best available donor, an optimized conditioning regimen is crucial to maximize outcomes for patients with TDT undergoing HSCT. The aim of this retrospective analysis was to investigate the role of busulfan-fludarabine-based and treosulfan-fludarabine-based conditioning in TDT patients undergoing HSCT. We included 772 patients registered in the European Society for Blood and Marrow Transplantation (EBMT) database who underwent first HSCT between 2010 and 2018. Four hundred ten patients received busulfan-fludarabine-based conditioning (median age 8.6 years) and 362 patients received treosulfan-fludarabine-based conditioning (median age 5.7 years). Patient outcomes were retrospectively compared by conditioning regimen. Two-year overall survival was 92.7% (95% confidence interval: 89.3-95.1%) after busulfan-fludarabine-based conditioning and 94.7% (95% confidence interval: 91.7-96.6%) after treosulfan-fludarabine-based conditioning. There was a very low incidence of second HSCT overall. The main causes of death were infections, graft-versus-host disease, and rejection. In conclusion, use of busulfan or treosulfan as the backbone of myeloablative conditioning for patients with TDT undergoing HSCT resulted in comparably high cure rates. Long-term follow-up studies are warranted to address the important issues of organ toxicities and gonadal function.

Published
2022
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39. O10 - CHARACTERIZATION OF TRANSCRIPTIONAL ALTERATIONS LEADING TO ABERRANT MYELOID DIFFERENTIATION IN MYELODYSPLASTIC SYNDROMES

Author

Diaz-Mazkiaran, A., De La Fuente, J., Serrano, G., Ainciburu, M., García-Olloqui, P., Berastegui, N., Alfonso, A., Vilas-Zornoza, A., San-Martin, P., Lamo-Espinosa, J.M., Julián, M. San, Acha, P., Solas, T. Jiménez, López-Cadenas, F., Molero, A., Montoro, M.J., Solé, F., Diez-Campelo, M., Valcárcel, D., Prosper, F., Hernaez, M., and Ezponda, T.

Published
2023
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44. Human immunodeficiency virus continuum of care in 11 european union countries at the end of 2016 overall and by key population: Have we made progress?

Author

Vourli, G, Noori, T, Pharris, A, Porter, K, Axelsson, M, Begovac, J, Cazein, F, Costagliola, D, Cowan, S, Croxford, S, Monforte, A, Delpech, V, Diaz, A, Girardi, E, Gunsenheimer-Bartmeyer, B, Hernando, V, Leierer, G, Lot, F, Nunez, O, Obel, N, Op de Coul, E, Paraskeva, D, Patrinos, S, Reiss, P, Schmid, D, Sonnerborg, A, Suligoi, B, Supervie, V, van Sighem, A, Zangerle, R, Touloumi, G, Egle, A, Kanatschnig, M, Ollinger, A, Rieger, A, Schmied, B, Wallner, E, Dewasurendra, D, Gisinger, M, Kitchen, M, Plattner, A, Rieser, E, Sarcletti, M, Greil, R, Schachner, M, Skocic, M, Muller, M, Aichwalder, R, Chromy, D, Grabmeier-Pfstershammer, K, Skoll, M, Touzeau, V, Cichon, P, Wolf-Nussmuller, S, Laferl, H, Zoufaly, A, Genger-Hackl, C, Kapper, A, Schneeberger, T, Trattner, E, Schober, G, Atzl, M, Hartmann, B, Puchhammer-Stockl, E, Berg, J, Appoyer, H, Rappold, M, Strickner, S, Schindelwig, K, Ledergerber, B, Fatkenheuer, G, Gerstof, J, Kronborg, G, Pedersen, C, Larsen, C, Pedersen, G, Mohey, R, Nielsen, L, Weise, L, Kvinesdal, B, Jensen, J, Abgrall, S, Bernard, L, Billaud, E, Boue, F, Boyer, L, Cabie, A, Caby, F, Canestri, A, Cotte, L, de Truchis, P, Duval, X, Duvivier, C, Enel, P, Fischer, H, Gasnault, J, Gaud, C, Grabar, S, Khuong-Josses, M, Launay, O, Marchand, L, Mary-Krause, M, Matheron, S, Melica-Gregoire, G, Melliez, H, Meynard, J, Nacher, M, Pavie, J, Piroth, L, Poizot-Martin, I, Pradier, C, Reynes, J, Rouveix, E, Simon, A, Slama, L, Tattevin, P, Tissot-Dupont, H, Biga, J, Kurth, T, Jacquemet, N, Guiguet, M, Leclercq, S, Lievre, L, Marshall, E, Roul, H, Selinger-Leneman, H, Potard, V, Benveniste, O, Breton, G, Lupin, C, Bourzam, E, Girard, P, Fonquernie, L, Valin, N, Lefebvre, B, Sebire, M, Pialoux, G, Lebrette, M, Tibaut, P, Adda, A, Hamidi, M, Cadranel, J, Lavole, A, Parrot, A, Bouchaud, O, Vignier, N, Mechai, F, Makhlouf, S, Honore, P, Bergmann, J, Delcey, V, Lopes, A, Sellier, P, Parrinello, M, Oksenhendler, E, Gerard, L, Molina, J, Rozenbaum, W, Denis, B, De Castro, N, Lascoux, C, Yazdanpanah, Y, Lariven, S, Joly, V, Rioux, C, Poupard, M, Taverne, B, Sutton, L, Masse, V, Genet, P, Wifaq, B, Gerbe, J, Grefe, S, Dupont, C, Freire Maresca, A, Reimann, E, Bloch, M, Meier, F, Mortier, E, Zeng, F, Montoya, B, Perronne, C, Mathez, D, Marigot-Outtandy, D, Berthe, H, Greder Belan, A, Terby, A, Godin Collet, C, Marque Juillet, S, Ruquet, M, Roussin-Bretagne, S, Colardelle, P, Granier, F, Laurichesse, J, Perronne, V, Akpan, T, Marcou, M, Daneluzzi, V, Veyssier-Belot, C, Masson, H, Welker, Y, Brazille, P, Kahn, J, Zucman, D, Majerholc, C, Fourn, E, Bornarel, D, Chambrin, V, Kansau, I, Raho-Moussa, M, Lelievre, J, Saidani, M, Chesnel, C, Dumont, C, Vittecoq, D, Derradji, O, Bolliot, C, Goujard, C, Teicher, E, Mole, M, Bourdic, K, Salmon, D, Le Jeunne, C, Guet, P, Pietri, M, Pannier Metzger, E, Marcou, V, Loulergue, P, Dupin, N, Morini, J, Deleuze, J, Gerhardt, P, Chanal, J, Weiss, L, Lucas, M, Jung, C, Ptak, M, Viard, J, Ghosn, J, Gazalet, P, Cros, A, 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S., Pedersen G., Mohey R., Nielsen L., Weise L., Kvinesdal B., Jensen J., Abgrall S., Bernard L., Billaud E., Boue F., Boyer L., Cabie A., Caby F., Canestri A., Cotte L., de Truchis P., Duval X., Duvivier C., Enel P., Fischer H., Gasnault J., Gaud C., Grabar S., Khuong-Josses M. A., Launay O., Marchand L., Mary-Krause M., Matheron S., Melica-Gregoire G., Melliez H., Meynard J. L., Nacher M., Pavie J., Piroth L., Poizot-Martin I., Pradier C., Reynes J., Rouveix E., Simon A., Slama L., Tattevin P., Tissot-Dupont H., Biga J., Kurth T., Jacquemet N., Guiguet M., Leclercq S., Lievre L., Marshall E., Roul H., Selinger-Leneman H., Potard V., Benveniste O., Breton G., Lupin C., Bourzam E., Girard P. M., Fonquernie L., Valin N., Lefebvre B., Sebire M., Pialoux G., Lebrette M. G., Tibaut P., Adda A., Hamidi M., Cadranel J., Lavole A., Parrot A., Bouchaud O., Vignier N., Mechai F., Makhlouf S., Honore P., Bergmann J. 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F., Delcey V., Lopes A., Sellier P., Parrinello M., Oksenhendler E., Gerard L., Molina J. M., Rozenbaum W., Denis B., De Castro N., Lascoux C., Yazdanpanah Y., Lariven S., Joly V., Rioux C., Poupard M., Taverne B., Sutton L., Masse V., Genet P., Wifaq B., Gerbe J., Grefe S., Dupont C., Freire Maresca A., Reimann E., Bloch M., Meier F., Mortier E., Zeng F., Montoya B., Perronne C., Mathez D., Marigot-Outtandy D., Berthe H., Greder Belan A., Terby A., Godin Collet C., Marque Juillet S., Ruquet M., Roussin-Bretagne S., Colardelle P., Granier F., Laurichesse J. J., Perronne V., Akpan T., Marcou M., Daneluzzi V., Veyssier-Belot C., Masson H., Welker Y., Brazille P., Kahn J. E., Zucman D., Majerholc C., Fourn E., Bornarel D., Chambrin V., Kansau I., Raho-Moussa M., Lelievre J. D., Saidani M., Chesnel C., Dumont C., Vittecoq D., Derradji O., Bolliot C., Goujard C., Teicher E., Mole M., Bourdic K., Salmon D., Le Jeunne C., Guet P., Pietri M. 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M., Jurriaans S., Back N. K. T., Zaaijer H. L., Berkhout B., Cornelissen M. T. E., Schinkel C. J., Wolthers K. C., Peters E. J. G., van Agtmael M. A., Bomers M., Sigalof K. C. E., Heitmuller M., Laan L. M., Ang C. W., van Houdt R., Jonges M., van Prehn J., Kuijpers T. W., Pajkrt D., Scherpbier H. J., de Boer C., van der Plas A., van den Berge M., Stegeman A., Baas S., Hage de Loof L., Wintermans B., Veenemans J., Pronk M. J. H., Ammerlaan H. S. M., de Munnik E. S., Jansz A. R., Tjhie J., Wegdam M. C. A., Deiman B., Scharnhorst V., van Eeden A., Brokking W., Elsenburg L. J. M., Nobel H., Damen M., van Kasteren M. E. E., Berrevoets M. A. H., Brouwer A. E., Adams A., de Kruijf-Van de Wiel B. A. F. M., Keelan-Pfaf S., van der Ven B., Buiting A. G. M., Murck J. L., Versteeg D., de Vries-Sluijs T. E. M. S., Bax H. I., van Gorp E. C. M., Nouwen J. L., Rijnders B. J. A., Schurink C. A. M., Verbon A., de Jong-Peltenburg N. C., Bassant N., van Beek J. E. A., Vriesde M., van Zonneveld L. 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J., Martinez L., Garcia J., Alcaraz B., Jimeno A., Poveda E., Pernas B., Mena A., Grandal M., Castro A., Pedreira J. D., Galera C., Albendin H., Iborra A., Campillo M. A., Vidal A., Amador C., Pasquau F., Ena J., Benito C., Fenoll V., Mohamed-Balghata M. O., Gomez M. A., Alberto de Zarraga M., Rivas M. E., Gorgolas M., Svedhem-Johansson V., Flamholc L., Gisslen M., Hejdeman B., Norgren H., and Wendahl S.

Abstract

Background. High uptake of antiretroviral treatment (ART) is essential to reduce human immunodeficiency virus (HIV) transmission and related mortality; however, gaps in care exist. We aimed to construct the continuum of HIV care (CoC) in 2016 in 11 European Union (EU) countries, overall and by key population and sex. To estimate progress toward the Joint United Nations Programme on HIV/AIDS (UNAIDS) 90-90-90 target, we compared 2016 to 2013 estimates for the same countries, representing 73% of the population in the region. Methods. A CoC with the following 4 stages was constructed: number of people living with HIV (PLHIV); proportion of PLHIV diagnosed; proportion of those diagnosed who ever initiated ART; and proportion of those ever treated who achieved viral suppression at their last visit. Results. We estimated that 87% of PLHIV were diagnosed; 92% of those diagnosed had ever initiated ART; and 91% of those ever on ART, or 73% of all PLHIV, were virally suppressed. Corresponding figures for men having sex with men were: 86%, 93%, 93%, 74%; for people who inject drugs: 94%, 88%, 85%, 70%; and for heterosexuals: 86%, 92%, 91%, 72%. The proportion suppressed of all PLHIV ranged from 59% to 86% across countries. Conclusions. The EU is close to the 90-90-90 target and achieved the UNAIDS target of 73% of all PLHIV virally suppressed, significant progress since 2013 when 60% of all PLHIV were virally suppressed. Strengthening of testing programs and treatment support, along with prevention interventions, are needed to achieve HIV epidemic control.

Published
2020

45. The role of haematopoietic stem cell transplantation for sickle cell disease in the era of targeted disease-modifying therapies and gene editing

Author

de la Fuente, J, Gluckman, E, Makani, J, Telfer, P, Faulkner, L, Corbacioglu, S, Amrolia, P, Ansari, M, Balduzzi, A, Dalassier, A, Dalle, J, Hereda Diaz, C, Feuchtinger, T, Locatelli, F, Lucchini, G, Galimard, J, Gonzalez Vincent, M, Handgretinger, R, Kleinschmidt, K, Lawitschka, A, Perez Martinez, A, Peters, C, Rocha, V, Ruggeri, A, Sedlacek, P, Svec, P, Toporski, J, Yesilipek, A, de la Fuente J., Gluckman E., Makani J., Telfer P., Faulkner L., Corbacioglu S., Amrolia P., Ansari M., Balduzzi A., Dalassier A., Dalle J. -H., Hereda Diaz C., Feuchtinger T., Locatelli F., Lucchini G., Galimard J. -E., Gonzalez Vincent M., Handgretinger R., Kleinschmidt K., Lawitschka A., Perez Martinez A., Peters C., Rocha V., Ruggeri A., Sedlacek P., Svec P., Toporski J., Yesilipek A., de la Fuente, J, Gluckman, E, Makani, J, Telfer, P, Faulkner, L, Corbacioglu, S, Amrolia, P, Ansari, M, Balduzzi, A, Dalassier, A, Dalle, J, Hereda Diaz, C, Feuchtinger, T, Locatelli, F, Lucchini, G, Galimard, J, Gonzalez Vincent, M, Handgretinger, R, Kleinschmidt, K, Lawitschka, A, Perez Martinez, A, Peters, C, Rocha, V, Ruggeri, A, Sedlacek, P, Svec, P, Toporski, J, Yesilipek, A, de la Fuente J., Gluckman E., Makani J., Telfer P., Faulkner L., Corbacioglu S., Amrolia P., Ansari M., Balduzzi A., Dalassier A., Dalle J. -H., Hereda Diaz C., Feuchtinger T., Locatelli F., Lucchini G., Galimard J. -E., Gonzalez Vincent M., Handgretinger R., Kleinschmidt K., Lawitschka A., Perez Martinez A., Peters C., Rocha V., Ruggeri A., Sedlacek P., Svec P., Toporski J., and Yesilipek A.

Abstract

Sickle cell disease is one of the most common, life-threatening, non-communicable diseases in the world and a major public health problem. Following the implementation of simple preventive and therapeutic modalities, infant mortality has almost been abolished in high-income countries, but only a small amount of progress has been made in improving survival in adulthood. Progressive end-organ damage, partly related to a systemic vasculopathy, is increasingly recognised. With the availability of a variety of novel disease-modifying drugs, gene addition and gene editing strategies, matched sibling donor haematopoietic stem cell transplantation (HSCT) in children (offering an overall survival rate of 95% and an event-free survival rate of 92%), and encouraging outcomes after alternative donor HSCT, the new challenge is to risk stratify patients, revise transplantation indications, and define the best therapeutic approach for each patient. The ultimate challenge will be to enable these advances in low-income and middle-income countries, where disease prevalence is highest and where innovative strategies are most needed.

Published
2020

48. Contact sensitization to limonene and linalool hydroperoxides in Spain: a GEIDAC* prospective study

Author

Deza, Gustavo, García‐Bravo, Begoña, Silvestre, Juan F., Pastor‐Nieto, Maria A., González‐Pérez, Ricardo, Heras‐Mendaza, Felipe, Mercader, Pedro, Fernández‐Redondo, Virginia, Niklasson, Bo, Giménez‐Arnau, Ana M., Hita, J. Armario, Hernando, L. Borrego, Carrillo, J. Carrascosa, Guijarro, S. Córdoba, Gavín, J. García, Ortega, M. Gattica, de la Fuente, J. Gómez, Hervella Garcés, M., de Frutos, J. Ortiz, Rodríguez Serna, M., Ruíz González, I., Sánchez Pedreño, P., Sánchez Pérez, J., and Baldrich, E. Serra

Published
2017
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