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Sweet corn was highly susceptible to senescence due to its elevated physiological metabolism after harvest, resulting in a decline in its edible quality. The aim of this study was to assess the effects of a cold storage insulation packaging box on the quality attributes of postharvest sweet corn (cv. 'Jinguan 218') during a simulated cold chain transportation period of 3 d and subsequent shelf life at room temperature (20 ℃) for 1 d. The control group involved cold storage at 4 ℃ to mimic refrigerated truck transportation. The results showed that the internal temperature of sweet corn packed in the cold storage insulation packaging box remained below 7 ℃ throughout the 3 d period. In comparison to the control group, the cold storage insulation packaging box effectively maintained the quality of sweet corn during cold chain transportation and shelf life, and delayed husk discoloration. The mass loss rate of sweet corn was reduced by 72.66% after 3 d of cold chain distribution using the packaging box, the soluble solid content was increased by 4.97%, and soluble sugar content was enhanced by 10.13%. Meanwhile, the activities of peroxidase (POD), catalase (CAT) and ascorbate peroxidase (APX) in sweet corn packaged with the cold storage insulation packaging box were significantly (P

Coal gangue, a by-product of coal mining, is accumulating rapidly and As a by-product of coal mining, the amount of coal gangue is increasing in stock, which poses a serious threat to the environment. Due to the high content of SiO2 and Al2O3 mass fraction, the use of gangue to prepare molecular sieves to capture CO2 in order to realize the efficient resource utilization of coal gangue is a promising technology. In this paper, zeolite molecular sieves are prepared by hydrothermal crystallization method with coal gangue as raw material, and the effects of KOH addition and coal semi-coke doping on the structure and properties of molecular sieves are investigated; static adsorption test of CO2 is carried out to study the CO2 capture characteristics of coal gangue-based zeolite molecular sieves and amine-modified molecular sieves. The results show that when the mass ratio of KOH to coal gangue is 2∶1, the specific surface area of the molecular sieve is 100.17 m2/g. When the doping amount of coal semi-coke is 40%, the molecular sieve has a specific surface area of 249.86 m2/g, and the total pore volume is 0.249 cm3/g. Under the optimal preparation conditions, the CO2 adsorption capacity of the molecular sieve is 1.16 mmol/g. Amine loading modification could effectively enhance the CO2 capture capacity of the molecular sieves, but excessive polyethyleneimine will accumulate in the molecular sieve pores and block the pore channels, resulting in the weakening of the physical adsorption capacity of the molecular sieves.

ABSTRACTLung adenocarcinoma (LADC) is the most common lung cancer and the leading cause of cancer-related deaths globally. Accumulating evidence suggests that the gut microbiota regulates the host response to chemotherapeutic drugs and can be targeted to reduce the toxicity of current chemotherapeutic agents. However, the effect of Diaphorobacter nitroreducens synergized with oxaliplatin on the gut microbiota and their impact on LADC have never been explored. This study aimed to evaluate the anti-cancer effects of D. nitroreducens, oxaliplatin, and their combined treatment on tumor growth in tumor-bearing mice. The composition of gut microbiota and the immune infiltration of tumors were evaluated by using 16S rRNA gene high-throughput sequencing and immunofluorescence, respectively. The inhibitory effect of the combination treatment with D. nitroreducens and oxaliplatin was significantly stronger than that of oxaliplatin alone in tumor-bearing mice. Furthermore, we observed that the combination treatment significantly increased the relative abundance of Lactobacillus and Akkermansia in the gut microbiota. Meanwhile, the combination treatment significantly increased the proportions of macrophage but decreased the proportion of regulatory T cells in the LADC tumor tissues of mice. These findings underscored the relationship between D. nitroreducens and the gut microbiota-immune cell-LADC axis, highlighting potential therapeutic avenues for LADC treatment.IMPORTANCEOxaliplatin is widely used as an effective chemotherapeutic agent in cancer treatment, but its side effects and response rate still need to be improved. Conventional probiotics potentially benefit cancer chemotherapy by regulating gut microbiota and tumor immune infiltration. This study was novel in reporting a more significant inhibitory effect of Diaphorobacter nitroreducens on lung adenocarcinoma (LADC) cells compared with common traditional probiotics and validating its potential as an adjuvant therapy for LADC chemotherapy in mice. This study investigated the impact of D. nitroreducens combined with oxaliplatin on the gut microbiota and immune infiltration of tumors as a potential mechanism to improve anticancer effects.

Lung cancer remains a leading cause of cancer-related mortality worldwide, with a complex molecular pathogenesis that is still not fully understood. Given the challenging task of distinguishing between subtypes of lung cancer (LUAD and LUSC), this study aimed to evaluate the potential of microRNAs (miRNAs) as biomarkers for differentiating these subtypes, by leveraging cancer genomics data. We used bioinformatics analysis for miRNA target prediction. In this regard, a miRNA-mRNA interaction network was defined and pathway analysis was subsequently established. To verify the results of the bioinformatic analysis, we conducted clinical and pre-clinical experiments. We carried out survival analysis, comparing gene expression and mortality rates between two major subtypes of lung cancer, LUSC and LUAD, from 45 lung cancer patients. Additionally, in vitro and in vivo studies were performed using human lung cancer cell lines to alter the expression of miR-21 and miR-326 using plasmid models. Finally, we conducted numerous assays to evaluate cell viability, cell migration and invasion, apoptosis, and cell cycle detection. We observed 102 miRNAs and 1,974 mRNAs as having differential expression in LUAD, whereas 143 miRNAs and 2,821 mRNAs were shown to have such an effect in LUSC. We found that hsa-mir-375 might significantly distinguish LUAD from LUSC, and our clinical validation demonstrated that the level of hsa-mir-375 was significantly higher in LUAD than in LUSC. In terms of finding a diagnostic marker, we discovered that a high level of hsa-mir-21 and/or hsa-mir-326 correlated with a worse prognosis. Our subsequent pre-clinical experiment showed that high expression of hsa-mir-21 and/or hsa-mir-326 significantly increased the aggressiveness of lung cancer and that inhibition of these miRNAs could potentially decrease the tumorigenic behavior of lung cancer cell lines. In conclusion, hsa-mir-21 and hsa-mir-326 might be potential diagnostic biomarkers for lung cancer and hsa-mir-375 might be a potential LUAD and LUSC distinguishing biomarker.

BackgroundHemodynamic instability is the main factor responsible for the development of intraventricular hemorrhage (IVH) in premature newborns. Herein, we evaluated the predictive ability of blood pressure variability (BPV) and anterior cerebral artery (ACA) blood flow parameters in IVH in premature infants with gestational age (GA) ≤32 weeks and birth weight (BW) ≤ 1,500 g.MethodsPreterm infants with GA ≤32 weeks and BW ≤ 1,500 g admitted to the neonatal intensive care unit (NICU) of the hospital affiliated to Yangzhou University from January 2020 to January 2023 were selected as the research subjects. All preterm infants were admitted within 1 h after birth, and systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial blood pressure (MABP) were monitored at 1-h intervals. The difference between maximum and minimum values (max-min), standard deviation (SD), coefficient of variation (CV), and successive variation (SV) were used as BPV indicators. On the 1st, 3rd, and 7th day after birth, transcranial ultrasound examination was performed to screen for the occurrence of IVH. On the 24 ± 1 h after birth, systolic velocity (Vs), diastolic velocity (Vd), and resistance index (RI) of the ACA were measured simultaneously. Preterm infants were divided into the IVH group and non-IVH group based on the results of transcranial ultrasound examination, and the correlation between BPV indicators, ACA blood flow parameters, and development of IVH was analyzed.ResultsA total of 92 premature infants were enrolled, including 49 in the IVH group and 43 in the non-IVH group. There was no statistically significant difference in baseline characteristics such as BW, GA, sex, and perinatal medical history between the two groups of preterm infants (P > 0.05). The SBP SD (OR: 1.480, 95%CI: 1.020–2.147) and ACA-RI (OR: 3.027, 95%CI: 2.769–3.591) were independent risk factors for IVH in premature newborns. The sensitivity and specificity of combined detection of SBP SD and ACA-RI in predicting IVH were 61.2% and 79.1%, respectively.ConclusionHigh BPV and ACA-RI are related to IVH in premature infants with GA ≤32 w and BW ≤1,500 g. Combined detection of SBP SD and ACA-RI has a certain predictive effect on early identification of IVH.

Abstract Exosomes can carry various kinds of RNAs to mediate intercellular communication. Circular RNA (circRNA) special AT‐rich sequence‐binding protein 2 (circSATB2) was identified as an oncogene in lung cancer. This study was performed to explore the association of circSATB2 with exosomes and the regulatory mechanism of circSATB2. Exosomes could transmit circSATB2 into lung cancer cells. Exosomes enhanced cell proliferation, invasion, and migration by carrying circSATB2. Exosomal circSATB2 abrogated the inhibitory effect of short hairpin (sh)‐circSATB2 on lung cancer progression. Moreover, circSATB2 promoted tumor growth in vivo via exosomes. CircSATB2 interacted with microRNA‐330‐5p (miR‐330‐5p) and miR‐330‐5p targeted pseudopodium enriched atypical kinase 1 (PEAK1). In addition, circSATB2 affected the PEAK1 level via sponging miR‐330‐5p in lung cancer cells. All results suggested that exosomal transfer of circSATB2 contributed to the malignant development of lung cancer by acting as a sponge of miR‐330‐5p to upregulate PEAK1.

Abstract The Huanglong travertine landscape, which is located on the eastern edge of the Qinghai‐Tibet Plateau, is a World Natural Heritage Site with important tourism, aesthetic and scientific research value. However, no convincing travertine sedimentary age data have been reported for this area, and these late Cenozoic terrestrial carbonates have not been effectively included in studies of the Qinghai‐Tibet Plateau geological environment. In this study, U‐series dating of the travertines was carried out using a multi‐collector inductively coupled plasma mass spectrometer to determine a time series for travertine deposition in the Dawan Valley (only a mountain away from Huanglong). The analyses of the processes operating during travertine deposition as the trench system evolved are performed based on a comprehensive study of the geological setting, structure and glacial landforms. The results suggest that travertine deposition in the Dawan Valley started at ca 13 ka and had begun to wane by the early Holocene (ca 7 ka). At the same time, the Huanglong Valley travertines began to be deposited on a large scale in response to a hydrological transition event. This event might reflect tectonic activity in particular, or possibly earthquakes or glacial retreat caused by climate warming. The findings reported here provide age data for late Cenozoic geological and environmental events such as climate variations and continental activity on the eastern margin of the Qinghai‐Tibet Plateau. It also presents new insights for research on glaciation, tectonic activity and seismicity; however, depositional breaks and forcing factors need to be explored further.

Metasurfaces have been widely used in the manufacture of various optical components in recent years. Based on all-dielectric metasurfaces, we proposed broadband, high-efficiency (over 83%) quarter-wave plates (QWP) and half-wave plates (HWP), respectively. The structure of the HWP we designed is equivalent to the superposition of two QWPs. The proposed QWP and HWP have high transmission efficiency, with bandwidths of 1376–1624 nm and 1411–1584 nm, respectively. Furthermore, based on the three-layer all-dielectric metasurfaces structure, we proposed a reversible bifunctional metasurface, which can realize the function of QWP and the effect of light deflection. This work may be conducive to the miniaturization and integration of polarization conversion devices.

Most of the significant petroleum- and coal-bearing sedimentary basins in Northeast Asia originated via rifting and thermal subsidence during the Late Jurassic-Early Cretaceous, followed by basin inversion in the Late Cretaceous. However, the tectonic background governing these basin prototype shifts has not been fully explored. The unconformities are excellent archives of plate boundary interactions and geodynamic switches in subduction zones. The Eastern Heilongjiang Province (EHLJ), Northeast China (NE China), comprises a series of Mesozoic-Cenozoic residual basins with well-preserved successions and provides significant insights into the tectonic characteristics and background of Northeast Asia. Mesozoic unconformities and large-scale contractional structures in the basins mark a series of important tectonic transitions in Northeast Asia. Based on the synthesis information of regional Mesozoic unconformities identified in the seismic reflection profiles and field outcrops of EHLJ, the tectonic characteristics and geodynamic background of the Mesozoic continental margin basins in Northeast Asia are analysed. The Middle-Upper Jurassic/basement unconformity (U1) can only be found in some areas of the Sanjiang and Hulin basins. It was a response to the continental collision of Siberia and the northern China–Mongolia tract along the Mongolia–Okhotsk suture during the Jurassic. The Paleo-Pacific Plate rapidly subducted in the NNW direction towards the eastern margin of Eurasia in the early Lower Cretaceous resulting in a mass of strike-slip faults and the widespread absence of deposits (Valanginian) (U2) in the EHLJ. Because of the subduction slab rollback of the Paleo-Pacific Plate during the late Lower Cretaceous, the local asthenospheric material upwelled, and fault and volcanic activities intensified in Northeast Asia. The Lower Cretaceous Dongshan Formation (Fm)/Muleng Fm unconformity (U3-1) reflects a specific scale of bimodal magmatism in the Songliao Basin and the EHLJ. The Pacific Plate subducted in a transformation from NNW to WNW during the early Upper Cretaceous (Cenomanian). The Houshigou Fm (Qixinhe Fm)/Lower Cretaceous angular unconformity (U3) reflects that on the basins experienced denudation after being extensively uplifted from the subduction events. With the subduction of the Kula Plate, a compression stress field during the later Upper Cretaceous Period controlled NE China. The basins underwent a widely compressive deformation, accompanied by large-scale thrusts, denudation and deplanation, resulting in Paleogene/Cretaceous unconformity (U4) was formed.

Abstract Background Preterm infants are a special population that vulnerable to respiratory syncytial virus (RSV) infection and the lower respiratory tract infections (LRTIs) caused by RSV could be severe and even life-threating. The purpose of the present study was to identify candidate genes of preterm infants who are susceptible to RSV infection and provide a new insight into the pathogenesis of RSV infection. Methods Three datasets (GSE77087, GSE69606 and GSE41374) containing 183 blood samples of RSV infected patients and 33 blood samples of healthy controls from Gene Expression Omnibus (GEO) database were downloaded and the differentially expressed genes (DEGs) were screened out. The function and pathway enrichments were analyzed through Database for Annotation, Visualization and Integrated Discovery (DAVID) website. The protein-protein interaction (PPI) network for DEGs was constructed through Search Tool for the Retrieval of Interacting Genes (STRING). The module analysis was performed by Cytoscape software and hub genes were identified. Clinical verification was employed to verify the expression level of top five hub genes among 72 infants including 50 RSV infected patients and 22 non-RSV-infected patients hospitalized in our center. Further, the RSV infected infants with high-expression IFI27 and those with low-expression IFI27 were compared (defined as higher or lower than the median mRNA level). Finally, the gene set enrichment analysis (GSEA) focusing on IFI27 was carried out. Results Totally, 4028 DEGs were screened out and among which, 131 most significant DEGs were selected. Subsequently, 13 hub genes were identified, and function and pathway enrichments of hub genes mainly were: response to virus, defense response to virus, regulation of viral genome replication and regulation of viral life cycle. Furthermore, IFI27 was confirmed to be the most significantly expressed in clinical verification. Gene sets associated with calcium signaling pathway, arachidonic acid metabolism, extracellular matrix receptor interaction and so on were significantly enriched when IFI27 was highly expressed. Moreover, high-expression IFI27 was associated with more severe cases (p = 0.041), more requirements of mechanical ventilation (p = 0.034), more frequent hospitalization (p

In recent years, watching online videos has gradually become an indispensable part of netizens’ daily lives. Almost all video sites have added the barrage function. Both barrage and comments are two important ways for users to participate and play an important role in online video viewing. Based on the barrage and comments of videos uploaded by users of the bilibili website, our research explores the impact of barrage and comments with different emotional tendencies on video popularity and their differences, and explores the moderating effect of comments on the impact of the barrage. We also propose a method for calculating the emotional intensity of barrage that considers the herd effect and the emotional attenuation. The study finds that barrage has a positive impact on video popularity, while the emotional intensity of positive comments has a negative impact on video popularity, and comments play a negative role in the impact of the barrage. It explains that barrage and comments have their advantages and disadvantages. Our research has expanded the research in related fields such as user-generated content and video popularity, and the research conclusions have important management significance for video websites. In future research, we can further refine the emotional classification and consider the impact of video characteristics (video content and subtitles) on video popularity.

In this paper, we consider the optimal reinsurance problem for a risk model with a thinning-dependence structure, where the stochastic sources related to claim occurrence are classified into different groups, and each group may cause a claim in each insurance class with some probability. We assume that the insurer can manage the risk by purchasing per-loss reinsurance, and their aim is to maximize the expected utility of the terminal wealth. By using the technique of stochastic control, we obtain the corresponding Hamilton–Jaccobi–Bellman equation. From the perspective of game theory, we derive the closed-form expression of the optimal strategy for each class of business, which is actually the best response to other given strategies. We also investigate the necessary conditions for optimal strategies and transfer the original optimization problem into a system of equations. Furthermore, we prove that the solution of the system of equations always exists, but may not be unique, and we also study some features of the optimal strategies in special cases and derive several interesting results. Finally, some numerical examples are given to show the impacts of some important parameters on the optimal strategies.

A series of MgAl _2 O _4 : x % Tb ^3+ ( x = 1.0–6.0) phosphors was prepared by a hydrothermal-assisted light burning method. The crystal structure, morphology and fluorescence properties of the samples were investigated. The results indicated that when the the hydrothermal and light burning temperatures were determined to be 120 °C and 1100 °C, respectively, the crystallinity for Mg _4 Al _2 (OH) _14 and NH _4 Al(OH) _2 CO _3 biphasic precursors is the best, conducive to generating pure phase MgAl _2 O _4 nanorod-like phosphors. The entry of Tb ^3+ into the MgAl _2 O _4 lattice can cause lattice distortion, but the main structure of the spinel does not change. The main emission peaks for the series of phosphors are located in the green light region of 546 nm. The MgAl _2 O _4 : 4.0% Tb ^3+ phosphor has the highest fluorescence intensity and shows the best colour quality. Its CIE coordinates (x, y), CCT and colour purity are determined to be (0.3171, 0.5290), 5845 K and 53.50%, respectively. The series of MgAl _2 O _4 : Tb ^3+ phosphors exhibits typical cold green light emission and have good application prospects in solid-state display devices.

Using game models, we study multiperiod coordination contract and model of coal-electricity supply chain under the condition of double price regulations to alleviate the price conflicts of coal and electricity enterprises. The study reveals that, in boom seasons of coal demand, the multiperiod coordination mechanism may not only reduce the price of thermal coal but also increase the fulfillment rate of thermal coal. Meanwhile, the ordering quantity of thermal coal is increased and the shortage probability of electricity supply is decreased. Thereby, the conflicts between coal and electricity are also alleviated effectively.

We report the creation of ultracold bosonic ^23 Na ^87 Rb Feshbach molecules via magneto-association. By ramping the magnetic field across an interspecies Feshbach resonance (FR), at least 4000 molecules can be produced out of the near degenerate ultracold mixture. Fast loss due to inelastic atom–molecule collisions is observed, which limits the pure molecule number, after residual atoms removal, to 1700. The pure molecule sample can live for 21.8(8) ms in the optical trap, long enough for future molecular spectroscopy studies toward coherently transferring to the singlet ro-vibrational ground state, where these molecules are stable against chemical reaction and have a permanent electric dipole moment of 3.3 Debye. We have also measured the Feshbach molecule’s binding energy near the FR by the oscillating magnetic field method and found these molecules have a large closed-channel fraction.

Objective: This study aims to investigate the relationship between serum vitamin D, total IgE levels and chronic spontaneous urticaria (CSU). Methods: We collected data from 101 patients with chronic spontaneous urticaria (experimental group) and 115 healthy normal subjects (control group) in the same period of physical examination. Results: The results showed that the number of deficient and absolute deficient 25-hydroxyvitamin D in the experimental group was significantly lower than in the control group (P < 0.05). Pearson correlation analysis showed that the activity score of CSU patients was negatively correlated with serum vitamin D (r = -0.2278, P = 0.0220) and positively correlated with IgE (r = 0.2078, P = 0.0380). It was observed that serum vitamin D in CSU patients was negatively correlated with their activity (r = -0.2278, P = 0.0220) and positively correlated with age (r = 0.2675, P = 0.0069). The Point-biserial correlation analysis revealed that gender was positively correlated with serum vitamin D (Pearson correlation coefficient = 0.286, P = 0.004) and UAS score (Pearson correlation coefficient = 0.273, P = 0.006). Ordinal logistic regression analysis showed that only serum vitamin D was correlated to activity scores (P = 0.008). In addition to activity scores, age ( P = 0.005) and gender (P = 0.04) were correlated to serum vitamin D. Conclusion: The activity score of CSU patients was negatively correlated with serum vitamin D and positively correlated with IgE. Serum vitamin D in CSU patients was negatively correlated with activity score and disease duration and positively correlated with age and gender. [ABSTRACT FROM AUTHOR]