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628 results on '"Fuchter, Matthew J."'

3. Anomalous circularly polarized light emission in organic light-emitting diodes caused by orbital-momentum locking

Author

Wan, Li, Liu, Yizhou, Fuchter, Matthew J., and Yan, Binghai

Subjects
Condensed Matter - Materials Science
Abstract

Chiral circularly polarized (CP) light is central to many photonic technologies, from optical communication of spin information to novel display and imaging technologies. As such, there has been significant effort in the development of chiral emissive materials that allow for the emission of strongly dissymmetric CP light from organic light-emitting diodes (OLEDs). A consensus for chiral emission in such devices is that the molecular chirality of the active layer determines the favored light handedness of CP emission, regardless of the light-emitting direction. Here, we discover that, unconventionally, oppositely propagating CP light exhibits opposite handedness, and reversing the current-flow in OLEDs also switches the handedness of the emitted CP light. This direction-dependent CP emission boosts the net polarization rate by orders of magnitude by resolving an established issue in CP-OLEDs, where the CP light reflected by the back electrode typically erodes the measured dissymmetry. Through detailed theoretical analysis, we assign this anomalous CP emission to a ubiquitous topological electronic property in chiral materials, namely the orbital-momentum locking. Our work paves the way to design new chiroptoelectronic devices and probes the close connections between chiral materials, topological electrons, and CP light in the quantum regime., Comment: 4 figures and supplementary materials

Published
2022
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6. Label-Free Chemical Nano-Imaging of Intracellular Drug Binding Sites

Author

Hart, William S., Amrania, Hemmel, Beckley, Alice, Brandt, Jochen R., Sundriyal, Sandeep, Rueda-Zubiaurre, Ainoa, Porter, Alexandra E., Aboagye, Eric O., Fuchter, Matthew J., and Phillips, Chris C.

Subjects
Physics - Biological Physics, Quantitative Biology - Quantitative Methods
Abstract

Optical microscopy has a diffraction limited resolution of about 250 nm. Fluorescence methods (e.g. PALM, STORM, STED) beat this, but they are still limited to 10 s of nm, and the images are an indirect pointillist representation of only part of the original object. Here we describe a way of combining a sample preparation technique taken from histopathology, with a probe-based nano-imaging technique, (s SNOM) from the world of Solid State Physics. This allows us to image subcellular structures optically, and at a nanoscale resolution that is about 100 x better than normal microscopes. By adding a tuneable laser source, we also demonstrate mid-infrared chemical nano-imaging (MICHNI) in human myeloma cells and we use it to map the binding sites of the anti cancer drug bortezomib to less than 10 zL sized intracellular components. MICHNI is label free and can be used with any biological material and drugs with specific functional chemistry. We believe that its combination of speed, cheapness, simplicity, safety and chemical contrast promises a transformative impact across the life sciences., Comment: 13 pages including supplementary information section. arXiv admin note: substantial text overlap with arXiv:1805.11466

Published
2020

9. Natural optical activity as the origin of the large chiroptical properties in π-conjugated polymer thin films.

Author

Wade, Jessica, Hilfiker, James N, Brandt, Jochen R, Liirò-Peluso, Letizia, Wan, Li, Shi, Xingyuan, Salerno, Francesco, Ryan, Seán TJ, Schöche, Stefan, Arteaga, Oriol, Jávorfi, Tamás, Siligardi, Giuliano, Wang, Cheng, Amabilino, David B, Beton, Peter H, Campbell, Alasdair J, and Fuchter, Matthew J

Abstract

Polymer thin films that emit and absorb circularly polarised light have been demonstrated with the promise of achieving important technological advances; from efficient, high-performance displays, to 3D imaging and all-organic spintronic devices. However, the origin of the large chiroptical effects in such films has, until now, remained elusive. We investigate the emergence of such phenomena in achiral polymers blended with a chiral small-molecule additive (1-aza[6]helicene) and intrinsically chiral-sidechain polymers using a combination of spectroscopic methods and structural probes. We show that - under conditions relevant for device fabrication - the large chiroptical effects are caused by magneto-electric coupling (natural optical activity), not structural chirality as previously assumed, and may occur because of local order in a cylinder blue phase-type organisation. This disruptive mechanistic insight into chiral polymer thin films will offer new approaches towards chiroptical materials development after almost three decades of research in this area.

Published
2020

11. Mid-infrared Chemical Nano-imaging for Intra-cellular Drug Localisation

Author

Hart, William S., Amrania, Hemmel, Beckley, Alice, Brandt, Jochen R., Sundriyal, Sandeep, Rueda-Zubiaurre, Ainoa, Porter, Alexandra E., Aboagye, Eric O., Fuchter, Matthew J., and Phillips, Chris C.

Subjects
Physics - Biological Physics, Condensed Matter - Mesoscale and Nanoscale Physics, Physics - Chemical Physics, Physics - Medical Physics, Physics - Optics
Abstract

In the past two decades a range of fluorescence cell microscopy techniques have been developed which can achieve ~10 nm spatial resolution, i.e. substantially beating the usual limits set by optical diffraction. However, these methods rely on specialised labelling. This limits the applicability, risks perturbing the biology, and it also makes them so-called "discovery techniques" that can only be used when there is prior knowledge about the biological problem. The alternative, electron microscopy (EM), requires complex and time-consuming sample preparation, that risks compromising the sample's integrity. Samples have to withstand vacuum, and staining with heavy metals to make them conductive, and give usable electron-contrast. None of these techniques can directly map out drug distributions at a sub-cellular level. Recently infrared light-based scanning probe techniques have demonstrated a capability for ~1 nm spatial resolution. However, they need samples that are flat, dry and dimensionally stable and they only probe down to a depth commensurate with the spatial resolution, so they yield essentially surface chemical information. Thus far they have been applied only to artificially produced test samples, e.g. gold particles, or isolated proteins on silicon. Here we show how these probe-based techniques can be adapted for use with routinely prepared general biological specimens. This allows for "Mid-infrared Chemical Nano-imaging" (MICHNI) that delivers chemical analysis at a ~10 nm spatial resolution, suitable for studying cellular ultrastructure. We demonstrate its utility by performing label-free mapping of the anti-cancer drug Bortezomib (BTZ) within a single human myeloma cell. We believe that this MICHNI technique has the potential to become a widely applicable adjunct to EM across the bio-sciences., Comment: 17 pages and 6 figures including supplementary information and references

Published
2018

19. Helitwistacenes—Combining Lateral and Longitudinal Helicity Results in Solvent‐Induced Inversion of Circularly Polarized Light

Author

Shioukhi, Israa, primary, Batchu, Harikrishna, additional, Schwartz, Gal, additional, Minion, Louis, additional, Deree, Yinon, additional, Bogoslavsky, Benny, additional, Shimon, Linda J. W., additional, Wade, Jessica, additional, Hoffman, Roy, additional, Fuchter, Matthew J., additional, Markovich, Gil, additional, and Gidron, Ori, additional

Published
2024
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21. The antimalarial efficacy and mechanism of resistance of the novel chemotype DDD01034957

Author

Miguel-Blanco, Celia, Murithi, James M., Benavente, Ernest Diez, Angrisano, Fiona, Sala, Katarzyna A., van Schalkwyk, Donelly A., Vanaerschot, Manu, Schwach, Frank, Fuchter, Matthew J., Billker, Oliver, Sutherland, Colin J., Campino, Susana G., Clark, Taane G., Blagborough, Andrew M., Fidock, David A., Herreros, Esperanza, Gamo, Francisco Javier, Baum, Jake, and Delves, Michael J.

Published
2021
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23. Incorporating Photoresponses into Porous Liquids.

Author

Brand, Michael C., Trowell, Hamish G., Fuchter, Matthew J., and Greenaway, Rebecca L.

Subjects
POROUS materials, LIQUIDS, SCIENTIFIC community, NUMBER systems
Abstract

Porous liquids combine the properties of a porous solid with those of a liquid, creating a porous flowable media. Since their discovery, these materials have gathered widespread interest within the scientific community, with substantial numbers of new systems being discovered, often with a focus on increasing the pore volume and gas capacity. Which begs the question, what does the future hold for porous liquids? Recently, the first examples of photoresponsive porous liquids have emerged, allowing changes in porosity to be observed under UV irradiation. Here, we expand on our previous report of photoresponsive porous liquids and explore the conceptualisation of responsive porous liquids and how these materials could be developed with the ability to respond to light, thereby offering a potential mechanism of controllable uptake and release in these systems. This concept article summarises different approaches that could be used to incorporate a photoresponse in a porous liquid before discussing recently reported systems, alongside important factors to consider in their design. Finally, by taking inspiration from the methods used to translate porous solids into the liquid state, combined with the field of photoresponsive materials, we discuss potential strategies that could be employed to realise further examples of photoresponsive porous liquids. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Disequilibrating azobenzenes by visible-light sensitization under confinement

Author

Gemen, Julius, primary, Church, Jonathan R., additional, Ruoko, Tero-Petri, additional, Durandin, Nikita, additional, Białek, Michał J., additional, Weißenfels, Maren, additional, Feller, Moran, additional, Kazes, Miri, additional, Odaybat, Magdalena, additional, Borin, Veniamin A., additional, Kalepu, Rishir, additional, Diskin-Posner, Yael, additional, Oron, Dan, additional, Fuchter, Matthew J., additional, Priimagi, Arri, additional, Schapiro, Igor, additional, and Klajn, Rafal, additional

Published
2023
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27. Data from ICEC0942, an Orally Bioavailable Selective Inhibitor of CDK7 for Cancer Treatment

Author

Patel, Hetal, primary, Periyasamy, Manikandan, primary, Sava, Georgina P., primary, Bondke, Alexander, primary, Slafer, Brian W., primary, Kroll, Sebastian H. B., primary, Barbazanges, Marion, primary, Starkey, Richard, primary, Ottaviani, Silvia, primary, Harrod, Alison, primary, Aboagye, Eric O., primary, Buluwela, Laki, primary, Fuchter, Matthew J., primary, Barrett, Anthony G. M., primary, Coombes, R. Charles, primary, and Ali, Simak, primary

Published
2023
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28. Supplementary Figure S7. from ICEC0942, an Orally Bioavailable Selective Inhibitor of CDK7 for Cancer Treatment

Author

Patel, Hetal, primary, Periyasamy, Manikandan, primary, Sava, Georgina P., primary, Bondke, Alexander, primary, Slafer, Brian W., primary, Kroll, Sebastian H. B., primary, Barbazanges, Marion, primary, Starkey, Richard, primary, Ottaviani, Silvia, primary, Harrod, Alison, primary, Aboagye, Eric O., primary, Buluwela, Laki, primary, Fuchter, Matthew J., primary, Barrett, Anthony G. M., primary, Coombes, R. Charles, primary, and Ali, Simak, primary

Published
2023
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29. Supplementary Table from Dual G9A/EZH2 Inhibition Stimulates Antitumor Immune Response in Ovarian High-Grade Serous Carcinoma

Author

Spiliopoulou, Pavlina, primary, Spear, Sarah, primary, Mirza, Hasan, primary, Garner, Ian, primary, McGarry, Lynn, primary, Grundland-Freile, Fabio, primary, Cheng, Zhao, primary, Ennis, Darren P., primary, Iyer, Nayana, primary, McNamara, Sophie, primary, Natoli, Marina, primary, Mason, Susan, primary, Blyth, Karen, primary, Adams, Peter D., primary, Roxburgh, Patricia, primary, Fuchter, Matthew J., primary, Brown, Bob, primary, and McNeish, Iain A., primary

Published
2023
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30. Supplementary Information from ICEC0942, an Orally Bioavailable Selective Inhibitor of CDK7 for Cancer Treatment

Author

Patel, Hetal, primary, Periyasamy, Manikandan, primary, Sava, Georgina P., primary, Bondke, Alexander, primary, Slafer, Brian W., primary, Kroll, Sebastian H. B., primary, Barbazanges, Marion, primary, Starkey, Richard, primary, Ottaviani, Silvia, primary, Harrod, Alison, primary, Aboagye, Eric O., primary, Buluwela, Laki, primary, Fuchter, Matthew J., primary, Barrett, Anthony G. M., primary, Coombes, R. Charles, primary, and Ali, Simak, primary

Published
2023
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31. Supplementary Data from Dual G9A/EZH2 Inhibition Stimulates Antitumor Immune Response in Ovarian High-Grade Serous Carcinoma

Author

Spiliopoulou, Pavlina, primary, Spear, Sarah, primary, Mirza, Hasan, primary, Garner, Ian, primary, McGarry, Lynn, primary, Grundland-Freile, Fabio, primary, Cheng, Zhao, primary, Ennis, Darren P., primary, Iyer, Nayana, primary, McNamara, Sophie, primary, Natoli, Marina, primary, Mason, Susan, primary, Blyth, Karen, primary, Adams, Peter D., primary, Roxburgh, Patricia, primary, Fuchter, Matthew J., primary, Brown, Bob, primary, and McNeish, Iain A., primary

Published
2023
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32. Supplementary Figure from Dual G9A/EZH2 Inhibition Stimulates Antitumor Immune Response in Ovarian High-Grade Serous Carcinoma

Author

Spiliopoulou, Pavlina, primary, Spear, Sarah, primary, Mirza, Hasan, primary, Garner, Ian, primary, McGarry, Lynn, primary, Grundland-Freile, Fabio, primary, Cheng, Zhao, primary, Ennis, Darren P., primary, Iyer, Nayana, primary, McNamara, Sophie, primary, Natoli, Marina, primary, Mason, Susan, primary, Blyth, Karen, primary, Adams, Peter D., primary, Roxburgh, Patricia, primary, Fuchter, Matthew J., primary, Brown, Bob, primary, and McNeish, Iain A., primary

Published
2023
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34. Supplementary Figure Legends 1-6 from The Development of a Selective Cyclin-Dependent Kinase Inhibitor That Shows Antitumor Activity

Author

Ali, Simak, primary, Heathcote, Dean A., primary, Kroll, Sebastian H.B., primary, Jogalekar, Ashutosh S., primary, Scheiper, Bodo, primary, Patel, Hetal, primary, Brackow, Jan, primary, Siwicka, Alekasandra, primary, Fuchter, Matthew J., primary, Periyasamy, Manikandan, primary, Tolhurst, Robert S., primary, Kanneganti, Seshu K., primary, Snyder, James P., primary, Liotta, Dennis C., primary, Aboagye, Eric O., primary, Barrett, Anthony G.M., primary, and Coombes, R. Charles, primary

Published
2023
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35. Supplementary Figures 1-6 from The Development of a Selective Cyclin-Dependent Kinase Inhibitor That Shows Antitumor Activity

Author

Ali, Simak, primary, Heathcote, Dean A., primary, Kroll, Sebastian H.B., primary, Jogalekar, Ashutosh S., primary, Scheiper, Bodo, primary, Patel, Hetal, primary, Brackow, Jan, primary, Siwicka, Alekasandra, primary, Fuchter, Matthew J., primary, Periyasamy, Manikandan, primary, Tolhurst, Robert S., primary, Kanneganti, Seshu K., primary, Snyder, James P., primary, Liotta, Dennis C., primary, Aboagye, Eric O., primary, Barrett, Anthony G.M., primary, and Coombes, R. Charles, primary

Published
2023
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36. Data from The Development of a Selective Cyclin-Dependent Kinase Inhibitor That Shows Antitumor Activity

Author

Ali, Simak, primary, Heathcote, Dean A., primary, Kroll, Sebastian H.B., primary, Jogalekar, Ashutosh S., primary, Scheiper, Bodo, primary, Patel, Hetal, primary, Brackow, Jan, primary, Siwicka, Alekasandra, primary, Fuchter, Matthew J., primary, Periyasamy, Manikandan, primary, Tolhurst, Robert S., primary, Kanneganti, Seshu K., primary, Snyder, James P., primary, Liotta, Dennis C., primary, Aboagye, Eric O., primary, Barrett, Anthony G.M., primary, and Coombes, R. Charles, primary

Published
2023
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37. Supplementary Tables 1-5 from The Development of a Selective Cyclin-Dependent Kinase Inhibitor That Shows Antitumor Activity

Author

Ali, Simak, primary, Heathcote, Dean A., primary, Kroll, Sebastian H.B., primary, Jogalekar, Ashutosh S., primary, Scheiper, Bodo, primary, Patel, Hetal, primary, Brackow, Jan, primary, Siwicka, Alekasandra, primary, Fuchter, Matthew J., primary, Periyasamy, Manikandan, primary, Tolhurst, Robert S., primary, Kanneganti, Seshu K., primary, Snyder, James P., primary, Liotta, Dennis C., primary, Aboagye, Eric O., primary, Barrett, Anthony G.M., primary, and Coombes, R. Charles, primary

Published
2023
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39. Materials for chiral light control

Author

Crassous, Jeanne, primary, Fuchter, Matthew J., additional, Freedman, Danna E., additional, Kotov, Nicholas A., additional, Moon, Jooho, additional, Beard, Matthew C., additional, and Feldmann, Sascha, additional

Published
2023
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40. Systematic Investigation into the Photoswitching and Thermal Properties of Arylazopyrazole-based MOF Host–Guest Complexes

Author

Griffiths, Kieran, Greenfield, Jake L., Halcovitch, Nathan R., Fuchter, Matthew J., Griffin, John M., Griffiths, Kieran, Greenfield, Jake L., Halcovitch, Nathan R., Fuchter, Matthew J., and Griffin, John M.

Abstract

A series of arylazopyrazole-loaded metal–organic frameworks were synthesized with the general formula Zn2(BDC)2(DABCO)(AAP)x (BDC = 1,4-benzenedicarboxylate; DABCO = 1,4-diazabicyclo-[2.2.2]octane; AAP = arylazopyrazole guest). The empty framework adopts a large pore tetragonal structure. Upon occlusion of the E-AAP guests, the frameworks contract to form narrow pore tetragonal structures. The extent of framework contraction is dependent on guest shapes and pendant groups and ranges between 1.5 and 5.8%. When irradiated with 365 nm light, the framework expands due to the photoisomerization of E-AAP to Z-AAP. The proportion of Z-isomer at the photostationary state varies between 19 and 57% for the AAP guests studied and appears to be limited by the framework which inhibits further isomerization once fully expanded. Interestingly, confinement within the framework significantly extends the thermal half-life of the Z-AAP isomers to a maximum of approximately 56 years. This finding provides scope for the design of photoresponsive host–guest complexes with high stability of the metastable isomer for long-duration information or energy storage applications.

Published
2023

41. A novel class of sulphonamides potently block malaria transmission by targeting a Plasmodium vacuole membrane protein

Author

Yahiya, Sabrina, primary, Saunders, Charlie N., additional, Hassan, Sarah, additional, Straschil, Ursula, additional, Fischer, Oliver J., additional, Rueda-Zubiaurre, Ainoa, additional, Haase, Silvia, additional, Vizcay-Barrena, Gema, additional, Famodimu, Mufuliat Toyin, additional, Jordan, Sarah, additional, Delves, Michael J., additional, Tate, Edward W., additional, Barnard, Anna, additional, Fuchter, Matthew J., additional, and Baum, Jake, additional

Published
2023
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45. Author Reply to Peer Reviews of Plasmodium falciparum protein Pfs16 is a target for transmission-blocking antimalarial drug development

Author

Yahiya, Sabrina, primary, Saunders, Charlie N, additional, Hassan, Sarah, additional, Straschil, Ursula, additional, Fischer, Oliver, additional, Rueda-Zubiaurre, Ainoa, additional, Haase, Silvia, additional, Vizcay-Barrena, Gema, additional, Famodimu, Mufuliat T, additional, Jordan, Sarah, additional, Delves, Michael, additional, Tate, Edward, additional, Barnard, Anna, additional, Fuchter, Matthew J, additional, and Baum, Jake, additional

Published
2022
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46. [5]-Helistatins: Tubulin-Binding Helicenes with Antimitotic Activity

Author

Rushworth, James L., primary, Thawani, Aditya R., additional, Fajardo-Ruiz, Elena, additional, Meiring, Joyce C. M., additional, Heise, Constanze, additional, White, Andrew J. P., additional, Akhmanova, Anna, additional, Brandt, Jochen R., additional, Thorn-Seshold, Oliver, additional, and Fuchter, Matthew J., additional

Published
2022
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48. Tuning Halide Composition Allows Low Dark Current Perovskite Photodetectors With High Specific Detectivity

Author

Furlan, Francesco, primary, Nodari, Davide, additional, Palladino, Emanuele, additional, Angela, Edoardo, additional, Mohan, Lokeshwari, additional, Briscoe, Joe, additional, Fuchter, Matthew J., additional, Macdonald, Thomas J., additional, Grancini, Giulia, additional, McLachlan, Martyn A., additional, and Gasparini, Nicola, additional

Published
2022
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49. A high throughput screen for next-generation leads targeting malaria parasite transmission

Author

Delves, Michael J., Miguel-Blanco, Celia, Matthews, Holly, Molina, Irene, Ruecker, Andrea, Yahiya, Sabrina, Straschil, Ursula, Abraham, Matthew, León, María Luisa, Fischer, Oliver J., Rueda-Zubiaurre, Ainoa, Brandt, Jochen R., Cortés, Álvaro, Barnard, Anna, Fuchter, Matthew J., Calderón, Félix, Winzeler, Elizabeth A., Sinden, Robert E., Herreros, Esperanza, Gamo, Francisco J., and Baum, Jake

Published
2018
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