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Space application refers to the direct and indirect technology utilization, product production, and service provision on the ground or in space by utilizing space resources, assets, and conditions. After over 60 years of development, the aerospace industry of China has made significant achievements, with over 400 satellites in orbit. However, the system design, basic database, and standards construction that are closely related to space application still cannot satisfy the requirements of high-quality development. Considering the demand for strengthening China's aerospace industry and the medium- and long-term development requirements of the industry, this study reviews the development status of space application in China and abroad, summarizes the new requirements for spaceapplication industry and technologies in China, and analyzes the challenges faced by space application. Moreover, the general ideas, development goals, and top-level systems of space application for strengthening China’s aerospace industry are proposed. The key directions for the development of space application are explored. Furthermore, we suggest that China should improve policies and regulations associated with the aerospace industry, promote the integration of space, ground, and users, and optimize mechanisms and services of the industry, so as to promote the formation of a coordinated space application pattern that features space-ground-user interactive development and unified standards.

Penicillium expansum is the main cause of apple rot. Besides, it can also produce mycotoxin patulin (PAT). Therefore, the search for substances that can inhibit the activity and toxigenicity of P. expansum has become a hot research topic. This study investigates the inhibitory effects of fengycin on patulin production in P. expansum. P. expansum was cultured under different environments with different concentrations of fengycin. The patulin content produced per unit weight of P. expansum mycelium was detected and determined by high pressure liquid chromatography (HPLC). Synergy brands (SYBR) GreenI Real-time PCR was used to detect the expression levels of 6-methylsalicylic acid synthase (6-MSAS) and isoepoxydon dehydrogenase (IDH), which were the key genes of producing patulin of P. expansum mycelium, in the conditions treated by fengycin and untreated. After fengycin treatments, not only the patulin content in every unit weight of P. expansum mycelium but also the expression level of 6-MSAS decreased significantly. The expression level of 6-MSAS of treatment was 0.11 folds of control. However, the expression level of IDH treated by fengycin decreased slightly. Fengycin could inhibit the P. expansum from producing patulin by downregulating the expression of key synthetic genes 6-MSAS.

To study the regulation effect of apple polyphenol on fat metabolism in mice. The mice were randomly divided into 5 groups, except the basic control group, the other 4 groups were given high fat diet, body weight was measured once a week, and the obesity model was established. The basal control group and the obesity model group were intragastrically given normal saline (4.2mg/(kgbw.d), The three dose groups were gavaged separately with apple polyphenol 4.2, 8.4, 12.6 mg/(kg bw. d). After 4 consecutive weeks, the body weight of mice, the contents of total cholesterol (TC), total triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), malondialdehyde (MDA) in serum and the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), liver lipase (HL) and lipoprotein lipase (LPL) in serum. should be measured respectively. Apple polyphenol can significantly reduce the body weight, TG, LDL-C, TC and MDA contents, coupled with the atherosclerosis index (AI) of obese mice. It can increase the serum HDL-C content of obese mice, and effectively increase the activities of SOD, GSH-Px, HL and LPL in mice. Apple Polyphenol can reduce blood lipid and prevent atherosclerosis via regulating fat metabolism in mice.

Objective: Investigate the status quo of the elderly living in the nursing home and their satisfaction and needs of nursing services, and analyze the service needs of the elderly living in the nursing home of Zhengzhou City. Methods: Randomly select 312 elderly people from 84 nursing homes for questionnaire survey and in-depth interview. Results: More than 60% of the respondents show their satisfaction on the current life in the nursing home. Sex, occupation, physical condition, dietary level, accommodation level, service level and health care conditions of the nursing home have a significant impact on the satisfaction of the elderly. Conclusion: With the growth of the aging of population, improving the level of service for the elderly and improve the service facilities is an essential way to improve the satisfaction and urgent needs of the elderly.

The aim of this study was to examine the ability of macroporous resin adsorption (MRA) to (1) adsorb and purify apple polyphenol, a natural flavonoid with antioxidant properties, and (2) optimize apple polyphenol purification. The adsorption and desorption rates were obtained as indices to compare five types of macroporous resins (MR) on the basis of adsorption and desorption performances of apple polyphenol. Apple polyphenol purification involved three independent variables, namely, flow rate, adsorption concentration, and pH; these variables were examined through response surface methodology. Results showed that optimal conditions were as follows: HPD-100 MR, 2.5 BV/hr flow rate, 0.44 Abs adsorption concentration, and pH 2.13. Under these conditions, the adsorption rate might increase to 95.27%. Therefore, MRA may serve as an effective method to separate and purify some active components from plants. [ABSTRACT FROM PUBLISHER]