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2. Schisandrin B suppresses liver fibrosis in rats by targeting miR-101-5p through the TGF-β signaling pathway

Author

Wang Cuiqiong, Xu Chao, Fu Xinling, and Jiang Yinyan

Subjects
Schisandrin B, miR-101-5p, liver fibrosis, TGF-β signalling, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5
Abstract

Schisandrin B (Sch B) and miR-101 family members play critical roles in the pathogenesis of liver fibrosis. However, the relationship between them has not been reported yet. Thus, this study aims to fill this research gap. Results showed that Sch B significantly upregulated the expression of miR-101-5p in HSC-T6 cells. Sch B also increased the expression of miR-101-5p by combined administration of TGF-β1 and Sch B. Using miR-101-5p inhibitor, we demonstrated that Sch B can target miR-101-5p through the TGF-β signalling pathway to regulate the proliferation and activation of HSC-T6 cells. A rat model of carbon tetrachloride-induced liver fibrosis was established, and results indicated that Sch B can attenuate liver fibrosis by upregulating the expression of miR-101-5p. In conclusion, Sch B can directly target miR-101 to suppress liver fibrosis. Sch B or miR-101-5p may be used as a therapeutic approach for the prevention and treatment of liver fibrosis.

Published
2020
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4. Schisandrin B suppresses liver fibrosis in rats by targeting miR-101-5p through the TGF-β signaling pathway

Author

Jiang Yinyan, Wang Cuiqiong, Fu Xinling, and Xu Chao

Subjects
Liver Cirrhosis, Male, Liver fibrosis, Biomedical Engineering, Pharmaceutical Science, Medicine (miscellaneous), 02 engineering and technology, Lignans, Rats, Sprague-Dawley, Pathogenesis, Cyclooctanes, 03 medical and health sciences, 0302 clinical medicine, Tgf β signaling, Transforming Growth Factor beta, Animals, Humans, Polycyclic Compounds, Tgf β signalling, Carbon Tetrachloride Poisoning, Chemistry, General Medicine, 021001 nanoscience & nanotechnology, Rats, MicroRNAs, 030220 oncology & carcinogenesis, Cancer research, Schisandrin B, 0210 nano-technology, Signal Transduction, Biotechnology
Abstract

Schisandrin B (Sch B) and miR-101 family members play critical roles in the pathogenesis of liver fibrosis. However, the relationship between them has not been reported yet. Thus, this study aims to fill this research gap. Results showed that Sch B significantly upregulated the expression of miR-101-5p in HSC-T6 cells. Sch B also increased the expression of miR-101-5p by combined administration of TGF-β1 and Sch B. Using miR-101-5p inhibitor, we demonstrated that Sch B can target miR-101-5p through the TGF-β signalling pathway to regulate the proliferation and activation of HSC-T6 cells. A rat model of carbon tetrachloride-induced liver fibrosis was established, and results indicated that Sch B can attenuate liver fibrosis by upregulating the expression of miR-101-5p. In conclusion, Sch B can directly target miR-101 to suppress liver fibrosis. Sch B or miR-101-5p may be used as a therapeutic approach for the prevention and treatment of liver fibrosis.

Published
2020

5. Pseudorabies virus pUL16 assists the nuclear import of VP26 through protein-protein interaction

Author

Xu, Jing-jing, primary, Cheng, Xue-fei, additional, Wu, Ji-qiang, additional, Zheng, Hao, additional, Tong, Wu, additional, Chen, Xiaoyong, additional, Ye, Chao, additional, Liu, Yuting, additional, Zhu, Haojie, additional, Fu, Xinling, additional, Jiang, Yifeng, additional, Kong, Ning, additional, Tong, Guangzhi, additional, Gao, Fei, additional, and Li, Guoxin, additional

Published
2021
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