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6. Featured Cover

Author

Zhao, Yujie, primary, Yang, Yang, additional, Lv, Weifu, additional, Zhu, Siyu, additional, Chen, Xiaoqiong, additional, Wang, Tao, additional, Huang, Mingsheng, additional, An, Taixue, additional, Duan, Chongyang, additional, Yu, Xiangrong, additional, Li, Qiyang, additional, Chen, Jinqiang, additional, Luo, Junyang, additional, Zhou, Shuoling, additional, Lu, Ligong, additional, Huang, Meiyan, additional, and Fu, Sirui, additional

Published
2024
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8. A modified model for predicting mortality after transjugular intrahepatic portosystemic shunt: A multicentre study

Author

Zhao, Yujie, primary, Yang, Yang, additional, Lv, Weifu, additional, Zhu, Siyu, additional, Chen, Xiaoqiong, additional, Wang, Tao, additional, Huang, Mingsheng, additional, An, Taixue, additional, Duan, Chongyang, additional, Yu, Xiangrong, additional, Li, Qiyang, additional, Chen, Jinqiang, additional, Luo, Junyang, additional, Zhou, Shuoling, additional, Lu, Ligong, additional, Huang, Meiyan, additional, and Fu, Sirui, additional

Published
2023
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13. Model containing sarcopenia and visceral adiposity can better predict the survival of hepatocellular carcinoma: A multicenter study

Author

Liu, Yao, primary, Fu, Sirui, additional, Yu, Xiangrong, additional, Zhang, Jinxiong, additional, Zhu, Siyu, additional, Yang, Yang, additional, Huang, Jianwen, additional, Luo, Hanlin, additional, Tang, Kai, additional, Zheng, Youbing, additional, Zhao, Yujie, additional, Chen, Xiaoqiong, additional, Zhan, Meixiao, additional, He, Xiaofeng, additional, Li, Qiyang, additional, Duan, Chongyang, additional, Chen, Yuan, additional, and Lu, Ligong, additional

Published
2023
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14. 3D Automatic Liver and Spleen Assessment in Preoperatively Predicting Overt Hepatic Encephalopathy Related to Transjugular Intrahepatic Portosystemic Shunt: A Multi-Center Study

Author

Chen, Xiaoqiong, primary, Wang, Tao, additional, Ji, Zhonghua, additional, Huang, Mingsheng, additional, Lv, Wei-Fu, additional, Wang, Haifang, additional, Zhao, Yujie, additional, Duan, Chong-Yang, additional, Yu, Xiangrong, additional, Li, Qiyang, additional, Zhang, Jiawei, additional, Chen, Jinqiang, additional, Zhang, Xiaoling, additional, Luo, Junyang, additional, Zhou, Shuoling, additional, Lu, Ligong, additional, Huang, Meiyan, additional, and Fu, Sirui, additional

Published
2023
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20. SUMO1 modification of methyltransferase-like 3 promotes tumor progression via regulating Snail mRNA homeostasis in hepatocellular carcinoma

Author

Yongjie Xin, Wenjun Ni, Yanyan Bai, Ligong Lu, Chenzi Yang, Fu Sirui, Wei Zhao, Hongfa Xu, Meixiao Zhan, Yong Li, Wei Li, and Hao Wang

Subjects
0301 basic medicine, China, Carcinoma, Hepatocellular, Methyltransferase, Hepatocellular carcinoma, SUMO-1 Protein, SUMOylations, SUMO protein, Medicine (miscellaneous), Mettl3, Snail, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Downregulation and upregulation, Western blot, biology.animal, medicine, Animals, Homeostasis, Humans, RNA, Messenger, Pharmacology, Toxicology and Pharmaceutics (miscellaneous), Mice, Inbred BALB C, medicine.diagnostic_test, biology, Oncogene, N6-methyladenosine, Liver Neoplasms, Hep G2 Cells, Methyltransferases, Prognosis, Xenograft Model Antitumor Assays, 030104 developmental biology, chemistry, Tumor progression, 030220 oncology & carcinogenesis, Disease Progression, Cancer research, Female, Snail Family Transcription Factors, N6-Methyladenosine, Research Paper
Abstract

Rationale: Hepatocellular carcinoma (HCC) is one of the leading causes of mortality worldwide. Methyltransferase-like 3 (Mettl3), an RNA N6-methyladenosine (m6A) methyltransferase, has been shown to act as an oncogene in several human cancers. However, the regulatory role of posttranslational modifications of Mettl3 in liver cancer remains elusive. Methods: SUMOylation was analyzed using immunoprecipitation and western blot assays. In vitro and in vivo biological functions were examined using MTS, colony formation, wound healing, transwell, apoptosis, and viability assays and the BALB/c nude mouse model, respectively. Immunohistochemistry was conducted to evaluate the prognostic value of Mettl3 expression in HCC. The regulatory mechanism of Mettl3 in HCC was investigated by m6A dot blot, immunofluorescence, dual luciferase reporter, protein stability, and RNA stability assays. Results: Mettl3 was found to be SUMOylated by a small ubiquitin-like modifier SUMO1. Further, SUMOylation of Mettl3 was increased upon mitogen stimulation, which correlated with UBC9 upregulation, and was positively correlated with high metastatic potential of liver cancer. Finally, SUMOylation of Mettl3 was found to regulate HCC progression via controlling Snail mRNA homeostasis in an m6A methyltransferase activity-dependent manner. Conclusions: This study revealed a novel mechanism of SUMOylated Mettl3-mediated Snail mRNA homeostasis, identifying the UBC9/SUMOylated Mettl3/Snail axis as a novel mediator of the SUMO pathway involved in HCC progression.

Published
2020

22. Deep Learning-Based Prediction of Future Extrahepatic Metastasis and Macrovascular Invasion in Hepatocellular Carcinoma

Author

Fu, Sirui, primary, Pan, Meiqing, additional, Zhang, Jie, additional, Zhang, Hui, additional, Tang, Zhenchao, additional, Li, Yong, additional, Mu, Wei, additional, Huang, Jianwen, additional, Dong, Di, additional, Duan, Chongyang, additional, Li, Xiaoqun, additional, Wang, Shuo, additional, Chen, Xudong, additional, He, Xiaofeng, additional, Yan, Jianfeng, additional, Lu, Ligong, additional, and Tian, Jie, additional

Published
2021
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24. Prediction of overt hepatic encephalopathy after transjugular intrahepatic portosystemic shunt treatment: a cohort study

Author

Kai Tang, Fu Sirui, Ligong Lu, Chongyang Duan, Yang Yang, Bin Cao, Jianwen Huang, Wenfeng Shi, Kenan Hao, Xiaofeng He, Shirui Yang, Xiao Bai, and Yong Li

Subjects
Adult, Liver Cirrhosis, Male, medicine.medical_specialty, Adolescent, medicine.medical_treatment, Decision curve, Nervous system toxicity, Subgroup analysis, Logistic regression, Combined model, Clinical factor, Cohort Studies, Young Adult, Risk Factors, Preoperative prediction, Internal medicine, Discrimination, medicine, Humans, Hepatic encephalopathy, Risk stratification, Aged, Retrospective Studies, Framingham Risk Score, Hepatology, business.industry, Middle Aged, Imaging characteristics, medicine.disease, Colorectal surgery, Treatment Outcome, Hepatic Encephalopathy, Calibration, TIPS, Female, Original Article, Radiology, Portasystemic Shunt, Transjugular Intrahepatic, business, Transjugular intrahepatic portosystemic shunt, Cohort study
Abstract

Background/purpose Overt hepatic encephalopathy (HE) risk should be preoperatively predicted to identify patients suitable for curative transjugular intrahepatic portosystemic shunt (TIPS) instead of palliative treatments. Methods A total of 185 patients who underwent TIPS procedure were randomised (130 in the training dataset and 55 in the validation dataset). Clinical factors and imaging characteristics were assessed. Three different models were established by logistic regression analyses based on clinical factors (ModelC), imaging characteristics (ModelI), and a combination of both (ModelCI). Their discrimination, calibration, and decision curves were compared, to identify the best model. Subgroup analysis was performed for the best model. Results ModelCI, which contained two clinical factors and two imaging characteristics, was identified as the best model. The areas under the curve of ModelC, ModelI, and ModelCI were 0.870, 0.963, and 0.978 for the training dataset and 0.831, 0.971, and 0.969 for the validation dataset. The combined model outperformed the clinical and imaging models in terms of calibration and decision curves. The performance of ModelCI was not influenced by total bilirubin, Child–Pugh stages, model of end-stage liver disease score, or ammonia. The subgroup with a risk score ≥ 0.88 exhibited a higher proportion of overt HE (training dataset: 13.3% vs. 97.4%, p p Conclusion Our combination model can successfully predict the risk of overt HE post-TIPS. For the low-risk subgroup, TIPS can be performed safely; however, for the high-risk subgroup, it should be considered more carefully. Graphic abstract

Published
2020

28. para-Aramid Nanofiber Membranes for High-Performance and Multifunctional Materials.

Author

Tang, Wei, Fu, Sirui, Luo, Nian, Fu, Qiang, and Chen, Feng

Abstract

In recent years, high-strength electrospinning nanofiber membranes have important applications in many fields, such as tissue engineering, filtration, lithium-ion battery separator, etc. Improving the mechanical strength of electrospinning nanofiber membranes has always been an important research topic. In this work, for the first time, an ultra-high-strength para-aramid nanofiber membrane is prepared by electrospinning of para-aramid nanofibril dispersion with the assistance of polyethylene oxide (PEO). The rheology and solution properties are investigated to determine the optimal composition of spinning solution. Electrospinning process parameters are studied to obtain a uniform morphology of the membranes. In order to achieve higher strength, the membranes with different forms are prepared by adjusting the arrangement and orientation of nanofibers, random membranes, oriented membranes, and nanofiber bundles. Among them, the fiber diameter is relatively uniform, between 100 and 200 nm. For random and oriented membranes, the mechanical properties can be greatly improved by heat treatment because PEO can act as physical cross-points to realize welding of nanofibers. Compared with the untreated membranes, the tensile strength increases to 40.36 and 65.82 MPa, respectively, increasing by 308 and 83%. Meanwhile, the morphology of the nanofiber membrane is not affected, and the porosity decreases slightly to 76 and 52%, respectively, and a decrease of 8 and 2%. In addition, the strength of the random membrane washed with water for 2 h can reach 83.56 MPa after heat treatment. For nanofiber bundles, the tensile strength exceeds 400 MPa. This work successfully achieves the preparation of ultra-high-strength electrospinning para-aramid nanofiber membranes, which have great application prospects in the field of high-performance and multifunctional materials, such as lithium-ion battery separators, filtration materials, and reinforced composite materials, etc. [ABSTRACT FROM AUTHOR]

Published
2022
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29. cMET promotes metastasis and epithelial‐mesenchymal transition in colorectal carcinoma by repressing RKIP.

Author

Wang, Siyun, Ma, Haiqing, Yan, Yan, Chen, Yu, Fu, Sirui, Wang, Junjiang, Wang, Ying, Chen, Hao, and Liu, Jianhua

Subjects
EPITHELIAL-mesenchymal transition, METASTASIS, BIOLOGICAL crosstalk, CANCER invasiveness, TREATMENT effectiveness
Abstract

Increasing evidence indicates that c‐mesenchymal‐epithelial transition factor (cMET) plays an important role in the malignant progression of colorectal cancer (CRC). However, the underlying mechanism is not fully understood. As a metastasis suppressor, raf kinase inhibitory protein (RKIP) loss has been reported in many cancer types. In this study, the expression levels of cMET and RKIP in CRC tissues and cell lines were determined, and their crosstalk and potential biological effects were explored in vitro and in vivo. Our results showed that cMET was inversely correlated with RKIP. Both cMET upregulation and RKIP downregulation indicated poor clinical outcomes. Moreover, the MAPK/ERK signaling pathway was implicated in the regulation of cMET and RKIP. Overexpression of cMET promoted tumor cell epithelial‐mesenchymal transition, invasion, migration, and chemoresistance, whereas the effects could be efficiently inhibited by increased RKIP. Notably, small hairpin RNA‐mediated cMET knockdown dramatically suppressed cell proliferation, although no RKIP‐induced influence on cell growth was observed in CRC. Altogether, cMET overexpression may contribute to tumor progression by inhibiting the antioncogene RKIP, providing preclinical justification for targeting RKIP to treat cMET‐induced metastasis of CRC. [ABSTRACT FROM AUTHOR]

Published
2021
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30. Advanced nanomaterials targeting hypoxia to enhance radiotherapy

Author

Li,Jia, Shang,Wenting, Li,Yong, Fu,Sirui, Tian,Jie, and Lu,Ligong

Subjects
International Journal of Nanomedicine
Abstract

Jia Li,1–3,* Wenting Shang,2,3,* Yong Li,1,* Sirui Fu,1–3 Jie Tian,2,3 Ligong Lu1 1Zhuhai Precision Medical Center, Zhuhai People’s Hospital, Jinan University, Zhuhai, China; 2CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing, China; 3Beijing Key Laboratory of Molecular Imaging, Beijing, China *These authors contributed equally to this work Abstract: Hypoxia within solid tumors is often responsible for the failure of radiotherapy. The development of hypoxia-targeting nanomaterials – aimed at enhancing the effect of radiotherapy by electrical or heat effects and at modulating hypoxia in the tumor microenvironment – is a promising strategy to address this issue. We provide an overview of recently developed advanced materials that potentiate radiotherapy. First, we summarize novel materials for oxygen delivery or production to modify the tumor microenvironment, thus improving the effects of ionizing radiation. Second, we present new approaches for the design of high-Z element–based multifunctional nanoplatforms to enhance radiotherapy. Third, novel drug delivery systems for hypoxic regions and hypoxia-inducible factor-1–targeted therapies are discussed. Fourth, we establish the effectiveness of X-ray- or near-infrared–responsive nanoparticles for selectively triggering therapeutic effects under hypoxic conditions. Finally, this review emphasizes the importance of research in the field of nanomedicine focused on tumor hypoxia to improve clinical outcomes. Keywords: radiotherapy, hypoxia, nanomaterials, hypoxia-inducible factor 1

Published
2018

40. Surface markers of liver cancer stem cells and innovative targeted-therapy strategies for HCC (Review).

Author

Qiu, Lige, Li, Hailiang, Fu, Sirui, Chen, Xiaofang, and Lu, Ligong

Subjects
LIVER cancer, CANCER stem cells, METASTASIS, DRUG resistance in cancer cells, PROGNOSIS
Abstract

Liver cancer stem cells (LCSCs) have important roles in the occurrence, development, recurrence, therapy resistance and metastasis of hepatocellular carcinoma (HCC). Therefore, intensive studies are undergoing to identify the mechanisms by which LCSCs contribute to HCC invasion and metastasis, and to design more efficient treatments for this disease. With continuous efforts in LCSC research over the years, therapies targeting LCSCs are thought to have great potential for the clinical treatment and prognosis of liver cancer. Novel LCSC surface markers are continuously discovered and several have been used in targeted therapies to reduce HCC recurrence, metastasis, and drug resistance following tumor resection. The present review describes the surface markers characterizing LCSCs and the recent progress in therapies targeting these markers, including antibodies and polypeptides. [ABSTRACT FROM AUTHOR]

Published
2018
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50. Corona Enhancement and Mosaic Architecture for Prognosis and Selection Between of Liver Resection Versus Transcatheter Arterial Chemoembolization in Single Hepatocellular Carcinomas >5 cm Without Extrahepatic Metastases: An Imaging-Based Retrospective Study.

Author

Meng Li, Yongjie Xin, Sirui Fu, Zaiyi Liu, Yong Li, Baoshan Hu, Shuting Chen, Changhong Liang, Ligong Lu, Li, Meng, Xin, Yongjie, Fu, Sirui, Liu, Zaiyi, Li, Yong, Hu, Baoshan, Chen, Shuting, Liang, Changhong, and Lu, Ligong

Published
2016
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