Author: "Fu, M. (Mao)" - Searchworks@Jio Institute Digital Library Search Results

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1. Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices

Author: Natarajan, P. (Pradeep), Pampana, A. (Akhil), Graham, S. E. (Sarah E.), Ruotsalainen, S. E. (Sanni E.), Perry, J. A. (James A.), de Vries, P. S. (Paul S.), Broome, J. G. (Jai G.), Pirruccello, J. P. (James P.), Honigbere, M. C. (Michael C.), Aragam, K. (Krishna), Wolford, B. (Brooke), Brody, J. A. (Jennifer A.), Antonacci-Fulton, L. (Lucinda), Arden, M. (Moscati), Aslibekyan, S. (Stella), Assimes, T. L. (Themistocles L.), Ballantyne, C. M. (Christie M.), Bielak, L. F. (Lawrence F.), Bisl, J. C. (Joshua C.), Cade, B. E. (Brian E.), Do, R. (Ron), Doddapaneni, H. (Harsha), Emery, L. S. (Leslie S.), Hung, Y.-J. (Yi-Jen), Irvin, M. R. (Marguerite R.), Khan, A. T. (Alyna T.), Lange, L. (Leslie), Lee, J. (Jiwon), Lemaitre, R. N. (Rozenn N.), Martin, L. W. (Lisa W.), Metcalf, G. (Ginger), Montasser, M. E. (May E.), Moon, J.-Y. (Jee-Young), Muzny, D. (Donna), Connell, J. R. (Jeffrey R. O.), Palmer, N. D. (Nicholette D.), Peralta, J. M. (Juan M.), Peyser, P. A. (Patricia A.), Stilp, A. M. (Adrienne M.), Tsai, M. (Michael), Wang, F. F. (Fei Fei), Weeks, D. E. (Daniel E.), Yanek, L. R. (Lisa R.), Wilson, J. G. (James G.), Abecasis, G. (Goncalo), Arnett, D. K. (Donna K.), Becker, L. C. (Lewis C.), Blangercy, J. (John), Boerwinkle, E. (Eric), Bowden, D. W. (Donald W.), Chang, Y.-C. (Yi-Cheng), Chen, Y. I. (Yii-Der, I), Choi, W. J. (Won Jung), Correa, A. (Adolfo), Curran, J. E. (Joanne E.), Daly, M. J. (Mark J.), DutcherE, S. K. (Susan K.), Ellinor, P. T. (Patrick T.), Fornage, M. (Myriam), Freedman, B. I. (Barry, I), Gabriel, S. (Stacey), Germer, S. (Soren), Gibbs, R. A. (Richard A.), He, J. (Jiang), Hveem, K. (Kristian), Jarvik, G. P. (Gail P.), Kaplan, R. C. (Robert C.), Kardia, S. L. (Sharon L. R.), Kennyn, E. (Eimear), Kim, R. W. (Ryan W.), Kooperberg, C. (Charles), Laurie, C. C. (Cathy C.), Lee, S. (Seonwook), Lloyd-Jones, D. M. (Don M.), Loos, R. J. (Ruth J. F.), Lubitz, S. A. (Steven A.), Mathias, R. A. (Rasika A.), Martinez, K. A. (Karine A. Viaud), McGarvey, S. T. (Stephen T.), Mitche, B. D. (Braxton D.), Nickerson, D. A. (Deborah A.), North, K. E. (Kari E.), Palotie, A. (Aarno), Park, C. J. (Cheol Joo), Psat, B. M. (Bruce M. Y.), Rao, D. C. (D. C.), Redline, S. (Susan), Reiner, A. P. (Alexander P.), Seo, D. (Daekwan), Seo, J.-S. (Jeong-Sun), Smith, A. V. (Albert, V), Tracy, R. P. (Russell P.), Kathiresan, S. (Sekar), Cupples, L. A. (L. Adrienne), Rotten, J. I. (Jerome, I), Morrison, A. C. (Alanna C.), Rich, S. S. (Stephen S.), Ripatti, S. (Samuli), Wilier, C. (Cristen), Peloso, G. M. (Gina M.), Vasan, R. S. (Ramachandran S.), Abe, N. (Namiko), Albert, C. (Christine), Almasy, L. (Laura), Alonso, A. (Alvaro), Ament, S. (Seth), Anderson, P. (Peter), Applebaum-Bowden, D. (Deborah), Arking, D. (Dan), Ashley-Koch, A. (Allison), Auer, P. (Paul), Avramopoulos, D. (Dimitrios), Barnard, J. (John), Barnes, K. (Kathleen), Barr, R. G. (R. Graham), Barron-Casella, E. (Emily), Beaty, T. (Terri), Becker, D. (Diane), Beer, R. (Rebecca), Begum, F. (Ferdouse), Beitelshees, A. (Amber), Benjamin, E. (Emelia), Bezerra, M. (Marcos), Bielak, L. (Larry), Blackwel, T. (Thomas), Bowler, R. (Russell), Broecke, U. (Ulrich), Bunting, K. (Karen), Burchard, E. (Esteban), Buth, E. (Erin), Cardwel, J. (Jonathan), Carty, C. (Cara), Casaburi, R. (Richard), Casella, J. (James), Chaffin, M. (Mark), Chang, C. (Christy), Chasman, D. (Daniel), Chavan, S. (Sameer), Chen, B.-J. (Bo-Juen), Chen, W.-M. (Wei-Min), Chol, M. (Michael), Choi, S. H. (Seung Hoan), Chuang, L.-M. (Lee-Ming), Chung, M. (Mina), Conomos, M. P. (Matthew P.), Cornell, E. (Elaine), Crapo, J. (James), Curtis, J. (Jeffrey), Custer, B. (Brian), Damcott, C. (Coleen), Darbar, D. (Dawood), Das, S. (Sayantan), David, S. (Sean), Davis, C. (Colleen), Daya, M. (Michelle), de Andrade, M. (Mariza), DeBaunuo, M. (Michael), Duan, Q. (Qing), Devine, R. D. (Ranjan Deka Dawn DeMeo Scott), Duggirala, Q. R. (Qing Ravi), Durda, J. P. (Jon Peter), Dutcher, S. (Susan), Eaton, C. (Charles), Ekunwe, L. (Lynette), Farber, C. (Charles), Farnaml, L. (Leanna), Fingerlin, T. (Tasha), Flickinger, M. (Matthew), Franceschini, N. (Nora), Fu, M. (Mao), Fullerton, S. M. (Stephanie M.), Fulton, L. (Lucinda), Gan, W. (Weiniu), Gao, Y. (Yan), Gass, M. (Margery), Ge, B. (Bruce), Geng, X. P. (Xiaoqi Priscilla), Gignoux, C. (Chris), Gladwin, M. (Mark), Glahn, D. (David), Gogarten, S. (Stephanie), Gong, D.-W. (Da-Wei), Goring, H. (Harald), Gu, C. C. (C. Charles), Guan, Y. (Yue), Guo, X. (Xiuqing), Haessler, J. (Jeff), Hall, M. (Michael), Harris, D. (Daniel), Hawle, N. Y. (Nicola Y.), Heavner, B. (Ben), Heckbert, S. (Susan), Hernandez, R. (Ryan), Herrington, D. (David), Hersh, C. (Craig), Hidalgo, B. (Bertha), Hixson, J. (James), Hokanson, J. (John), Hong, E. (Elliott), Hoth, K. (Karin), Hsiung, C. A. (Chao Agnes), Huston, H. (Haley), Hwu, C. M. (Chii Min), Jackson, R. (Rebecca), Jain, D. (Deepti), Jaquish, C. (Cashell), Jhun, M. A. (Min A.), Johnsen, J. (Jill), Johnson, A. (Andrew), Johnson, C. (Craig), Johnston, R. (Rich), Jones, K. (Kimberly), Kang, H. M. (Hyun Min), Kaufman, L. (Laura), Kell, S. Y. (Shannon Y.), Kessler, M. (Michael), Kinney, G. (Greg), Konkle, B. (Barbara), Kramer, H. (Holly), Krauter, S. (Stephanie), Lange, C. (Christoph), Lange, E. (Ethan), Laurie, C. (Cecelia), LeBoff, M. (Meryl), Lee, S. S. (Seunggeun Shawn), Lee, W.-J. (Wen-Jane), LeFaive, J. (Jonathon), Levine, D. (David), Levy, D. (Dan), Lewis, J. (Joshua), Li, Y. (Yun), Lin, H. (Honghuang), Lin, K. H. (Keng Han), Lin, X. (Xihong), Liu, S. (Simin), Liu, Y. (Yongmei), Lunetta, K. (Kathryn), Luo, J. (James), Mahaney, M. (Michael), Make, B. (Barry), Manichaikul, A. (Ani), Mansonl, J. (JoAnn), Margolin, L. (Lauren), Mathai, S. (Susan), McArdle, P. (Patrick), Mcdonald, M.-L. (Merry-Lynn), McFarland, S. (Sean), McHugh, C. (Caitlin), Mei, H. (Hao), Meyers, D. A. (Deborah A.), Mikulla, J. (Julie), Min, N. (Nancy), Minear, M. (Mollie), Minster, R. L. (Ryan L.), Musani, S. (Solomon), Mwasongwe, S. (Stanford), Mychaleckyj, J. C. (Josyf C.), Nadkarni, G. (Girish), Naik, R. (Rakhi), Naseri, T. (Take), Nekhai, S. (Sergei), Nelson, S. C. (Sarah C.), Nickerson, D. (Deborah), Connell, J. O. (Jeff O.), Connor, T. O. (Tim O.), Ochs-Balcom, H. (Heather), Pankow, J. (James), Papanicolaou, G. (George), Parkerl, M. (Margaret), Parsa, A. (Afshin), Penchey, S. (Sara), Perez, M. (Marco), Peters, U. (Ulrike), Phillips, L. S. (Lawrence S.), Phillips, S. (Sam), Pollin, T. (Toni), Post, W. (Wendy), Becker, J. P. (Julia Powers), Boorgula, M. P. (Meher Preethi), Preuss, M. (Michael), Prokopenko, D. (Dmitry), Qasba, P. (Pankaj), Qiao, D. (Dandi), Rafaels, N. (Nicholas), Raffield, L. (Laura), Rasmussen-Torvik, L. (Laura), Ratan, A. (Aakrosh), Reed, R. (Robert), Reganl, E. (Elizabeth), Reupena, M. S. (Muagututi Sefuiva), Rice, K. (Ken), Roden, D. (Dan), Roselli, C. (Carolina), Ruczinski, I. (Ingo), Russel, P. (Pamela), Ruuska, S. (Sarah), Ryan, K. (Kathleen), Sabino, E. C. (Ester Cerdeira), Sakornsakolpatl, P. (Phuwanat), Salzberg, S. (Steven), Sandow, K. (Kevin), Sankaran, V. G. (Vijay G.), Scheller, C. (Christopher), Schmidt, E. (Ellen), Schwander, K. (Karen), Schwartz, D. (David), Sciurba, F. (Frank), Seidman, C. (Christine), Seidman, J. (Jonathan), Sheehan, V. (Vivien), Shetty, A. (Amol), Shetty, A. (Aniket), Sheu, W. H. (Wayne Hui-Heng), Shoemaker, M. B. (M. Benjamin), Silver, B. (Brian), Silvermanl, E. (Edwin), Smith, J. (Jennifer), Smith, J. (Josh), Smith, N. (Nicholas), Smith, T. (Tanja), Smoller, S. (Sylvia), Snively, B. (Beverly), Soferlm, T. (Tamar), Streeten, E. (Elizabeth), Su, J. L. (Jessica Lasky), Sung, Y. J. (Yun Ju), Sylvia, J. (Jody), Sztalryd, C. (Carole), Taliun, D. (Daniel), Tang, H. (Hua), Taub, M. (Margaret), Taylor, K. D. (Kent D.), Taylor, S. (Simeon), Telen, M. (Marilyn), Thornton, T. A. (Timothy A.), Tinker, L. (Lesley), Tirschwel, D. (David), Tiwari, H. (Hemant), Vaidya, D. (Dhananjay), VandeHaar, P. (Peter), Vrieze, S. (Scott), Walker, T. (Tarik), Wallace, R. (Robert), Waits, A. (Avram), Wan, E. (Emily), Wang, H. (Heming), Watson, K. (Karol), Weir, B. (Bruce), Weiss, S. (Scott), Weng, L.-C. (Lu-Chen), Williams, K. (Kayleen), Williams, L. K. (L. Keoki), Wilson, C. (Carla), Wong, Q. (Quenna), Xu, H. (Huichun), Yang, I. (Ivana), Yang, R. (Rongze), Zaghlou, N. (Norann), Zekavat, M. (Maryam), Zhang, Y. (Yingze), Zhao, S. X. (Snow Xueyan), Zhao, W. (Wei), Zni, D. (Degui), Zhou, X. (Xiang), Zhu, X. (Xiaofeng), Zody, M. (Michael), Zoellner, S. (Sebastian), Daly, M. (Mark), Jacob, H. (Howard), Matakidou, A. (Athena), Runz, H. (Heiko), John, S. (Sally), Plenge, R. (Robert), McCarthy, M. (Mark), Hunkapiller, J. (Julie), Ehm, M. (Meg), Waterworth, D. (Dawn), Fox, C. (Caroline), Malarstig, A. (Anders), Klinger, K. (Kathy), Call, K. (Kathy), Mkel, T. (Tomi), Kaprio, J. (Jaakko), Virolainen, P. (Petri), Pulkki, K. (Kari), Kilpi, T. (Terhi), Perola, M. (Markus), Partanen, J. (Jukka), Pitkranta, A. (Anne), Kaarteenaho, R. (Riitta), Vainio, S. (Seppo), Savinainen, K. (Kimmo), Kosma, V.-M. (Veli-Matti), Kujala, U. (Urho), Tuovila, O. (Outi), Hendolin, M. (Minna), Pakkanen, R. (Raimo), Waring, J. (Jeff), Riley-Gillis, B. (Bridget), Liu, J. (Jimmy), Biswas, S. (Shameek), Diogo, D. (Dorothee), Marshall, C. (Catherine), Hu, X. (Xinli), Gossel, M. (Matthias), Schleutker, J. (Johanna), Arvas, M. (Mikko), Hinttala, R. (Reetta), Kettunen, J. (Johannes), Laaksonen, R. (Reijo), Mannermaa, A. (Arto), Paloneva, J. (Juha), Soininen, H. (Hilkka), Julkunen, V. (Valtteri), Remes, A. (Anne), Klviinen, R. (Reetta), Hiltunen, M. (Mikko), Peltola, J. (Jukka), Tienari, P. (Pentti), Rinne, J. (Juha), Ziemann, A. (Adam), Waring, J. (Jeffrey), Esmaeeli, S. (Sahar), Smaoui, N. (Nizar), Lehtonen, A. (Anne), Eaton, S. (Susan), Landenper, S. (Sanni), Michon, J. (John), Kerchner, G. (Geoff), Bowers, N. (Natalie), Teng, E. (Edmond), Eicher, J. (John), Mehta, V. (Vinay), Gormle, P. Y. (Padhraig Y.), Linden, K. (Kari), Whelan, C. (Christopher), Xu, F. (Fanli), Pulford, D. (David), Frkkil, M. (Martti), Pikkarainen, S. (Sampsa), Jussila, A. (Airi), Blomster, T. (Timo), Kiviniemi, M. (Mikko), Voutilainen, M. (Markku), Georgantas, B. (Bob), Heap, G. (Graham), Rahimov, F. (Fedik), Usiskin, K. (Keith), Maranville, J. (Joseph), Lu, T. (Tim), Oh, D. (Danny), Kalpala, K. (Kirsi), Miller, M. (Melissa), McCarthy, L. (Linda), Eklund, K. (Kari), Palomki, A. (Antti), Isomki, P. (Pia), Piri, L. (Laura), Kaipiainen-Seppnen, O. (Oili), Lertratanaku, A. (Apinya), Bing, D. C. (David Close Marla Hochfeld Nan), Gordillo, J. E. (Jorge Esparza), Mars, N. (Nina), Laitinen, T. (Tarja), Pelkonen, M. (Margit), Kauppi, P. (Paula), Kankaanranta, H. (Hannu), Harju, T. (Terttu), Greenberg, S. (Steven), Chen, H. (Hubert), Betts, J. (Jo), Ghosh, S. (Soumitra), Salomaa, V. (Veikko), Niiranen, T. (Teemu), Juonala, M. (Markus), Metsrinne, K. (Kaj), Khnen, M. (Mika), Junttila, J. (Juhani), Laakso, M. (Markku), Pihlajamki, J. (Jussi), Sinisalo, J. (Juha), Taskinen, M.-R. (Marja-Riitta), Tuomi, T. (Tiinamaija), Laukkanen, J. (Jari), Challis, B. (Ben), Peterson, A. (Andrew), Chu, A. (Audrey), Parkkinen, J. (Jaakko), Muslin, A. (Anthony), Joensuu, H. (Heikki), Meretoja, T. (Tuomo), Aaltonen, L. (Lauri), Auranen, A. (Annika), Karihtala, P. (Peeter), Kauppila, S. (Saila), Auvinen, P. (Pivi), Elenius, K. (Klaus), Popovic, R. (Relja), Schutzman, J. (Jennifer), Loboda, A. (Andrey), Chhibber, A. (Aparna), Lehtonen, H. (Heli), McDonough, S. (Stefan), Crohns, M. (Marika), Kulkarni, D. (Diptee), Kaarniranta, K. (Kai), Turunen, J. (Joni), Ollila, T. (Terhi), Seitsonen, S. (Sanna), Uusitalo, H. (Hannu), Aaltonen, V. (Vesa), Uusitalo-Jrvinen, H. (Hannele), Luodonp, M. (Marja), Hautala, N. (Nina), Strauss, E. (Erich), Chen, H. (Hao), Podgornaia, A. (Anna), Hoffman, J. (Joshua), Tasanen, K. (Kaisa), Huilaja, L. (Laura), Hannula-Jouppi, K. (Katariina), Salmi, T. (Teea), Peltonen, S. (Sirkku), Koulu, L. (Leena), Harvima, I. (Ilkka), Wu, Y. (Ying), Choy, D. (David), Jalanko, A. (Anu), Kajanne, R. (Risto), Lyhs, U. (Ulrike), Kaunisto, M. (Mari), Davis, J. W. (Justin Wade), Quarless, D. (Danjuma), Petrovski, S. (Slav), Chen, C.-Y. (Chia-Yen), Bronson, P. (Paola), Yang, R. (Robert), Chang, D. (Diana), Bhangale, T. (Tushar), Holzinger, E. (Emily), Wang, X. (Xulong), Chen, X. (Xing), Auro, K. (Kirsi), Wang, C. (Clarence), Xu, E. (Ethan), Auge, F. (Franck), Chatelain, C. (Clement), Kurki, M. (Mitja), Karjalainen, J. (Juha), Havulinna, A. (Aki), Palin, K. (Kimmo), Palta, P. (Priit), Parolo, P. D. (Pietro Della Briotta), Zhou, W. (Wei), Lemmel, S. (Susanna), Rivas, M. (Manuel), Harju, J. (Jarmo), Lehisto, A. (Arto), Ganna, A. (Andrea), Llorens, V. (Vincent), Karlsson, A. (Antti), Kristiansson, K. (Kati), Hyvrinen, K. (Kati), Ritari, J. (Jarmo), Wahlfors, T. (Tiina), Koskinen, M. (Miika), Pylkäs, K. (Katri), Kalaoja, M. (Marita), Karjalainen, M. (Minna), Mantere, T. (Tuomo), Kangasniemi, E. (Eeva), Heikkinen, S. (Sami), Laakkonen, E. (Eija), Kononen, J. (Juha), Loukola, A. (Anu), Laiho, P. (Pivi), Sistonen, T. (Tuuli), Kaiharju, E. (Essi), Laukkanen, M. (Markku), Jrvensivu, E. (Elina), Lhteenmki, S. (Sini), Mnnikk, L. (Lotta), Wong, R. (Regis), Mattsson, H. (Hannele), Hiekkalinna, T. (Tero), Jimnez, M. G. (Manuel Gonzlez), Donner, K. (Kati), Prn, K. (KaIle), Nunez-Fontarnau, J. (Javier), Kilpelinen, E. (Elina), Sipi, T. P. (Timo P.), Brein, G. (Georg), Dada, A. (Alexander), Awaisa, G. (Ghazal), Shcherban, A. (Anastasia), Sipil, T. (Tuomas), Laivuori, H. (Hannele), Kiiskinen, T. (Tuomo), Siirtola, H. (Harri), Tabuenca, J. G. (Javier Gracia), Kallio, L. (Lila), Soini, S. (Sirpa), Pitknen, K. (Kimmo), and Kuopio, T. (Teijo)
Subjects: Cardiovascular genetics, Genome-wide association studies
Abstract: Autosomal genetic analyses of blood lipids have yielded key insights for coronary heart disease (CHD). However, X chromosome genetic variation is understudied for blood lipids in large sample sizes. We now analyze genetic and blood lipid data in a high-coverage whole X chromosome sequencing study of 65,322 multi-ancestry participants and perform replication among 456,893 European participants. Common alleles on chromosome Xq23 are strongly associated with reduced total cholesterol, LDL cholesterol, and triglycerides (min P = 8.5 × 10−72), with similar effects for males and females. Chromosome Xq23 lipid-lowering alleles are associated with reduced odds for CHD among 42,545 cases and 591,247 controls (P = 1.7 × 10−4), and reduced odds for diabetes mellitus type 2 among 54,095 cases and 573,885 controls (P = 1.4 × 10−5). Although we observe an association with increased BMI, waist-to-hip ratio adjusted for BMI is reduced, bioimpedance analyses indicate increased gluteofemoral fat, and abdominal MRI analyses indicate reduced visceral adiposity. Co-localization analyses strongly correlate increased CHRDL1 gene expression, particularly in adipose tissue, with reduced concentrations of blood lipids.
Published: 2021

2. Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults

Author: Graff, M.J. (Maud J.L.), Scott, R.A. (Robert), Justice, A.E. (Anne), Young, K.L. (Kristin L.), Feitosa, M.F. (Mary Furlan), Barata, L. (Llilda), Winkler, T.W. (Thomas W.), Chu, A.Y. (Audrey), Mahajan, A. (Anubha), Hadley, D. (David), Xue, L. (Luting), Workalemahu, T. (Tsegaselassie), Heard-Costa, N.L. (Nancy), Hoed, M. (Marcel) den, Ahluwalia, T.S. (Tarunveer Singh), Qi, Q., Ngwa, J.S., Renström, F. (Frida), Quaye, L. (Lydia), Eicher, J.D. (John D.), Hayes, J.E. (James E.), Cornelis, M. (Marilyn), Kutalik, Z. (Zoltán), Lim, E. (Elise), Luan, J. (Jian'An), Huffman, J.E. (Jennifer), Zhang, W. (Weihua), Zhao, W. (Wei), Griffin, P.J. (Paula J.), Haller, T. (Toomas), Ahmad, S. (Shafqat), Marques-Vidal, P. (Pedro), Bien, S. (Stephanie), Yengo, L. (Loic), Teumer, A. (Alexander), Smith, A.V. (Albert Vernon), Kumari, M. (Meena), Harder, M.N. (Marie Neergaard), Justesen, J.M. (Johanne M.), Kleber, M.E. (Marcus), Hollensted, M. (Mette), Lohman, K. (Kurt), Rivera, N.V. (Natalia), Whitfield, J.B. (John B.), Zhao, J.H. (Jing Hua), Stringham, H.M. (Heather), Lyytikäinen, L.-P. (Leo-Pekka), Huppertz, C. (Charlotte), Willemsen, G.A.H.M. (Gonneke), Peyrot, W.J. (Wouter ), Wu, Y. (Ying), Kristiansson, K. (Kati), Demirkan, A. (Ayşe), Fornage, M. (Myriam), Hassinen, M. (Maija), Bielak, L.F. (Lawrence F.), Cadby, G. (Gemma), Tanaka, T. (Toshiko), Mägi, R. (Reedik), Most, P.J. (Peter) van der, Jackson, A.U. (Anne), Bragg-Gresham, J.L. (Jennifer L.), Vitart, V. (Veronique), Marten, J. (Jonathan), Navarro, P. (Pau), Bellis, C. (Claire), Pasko, D. (Dorota), Johansson, Å. (Åsa), Snitker, S. (Soren), Cheng, Y.-C. (Yu-Ching), Eriksson, J. (Joel), Lim, U. (Unhee), Aadahl, M. (Mette), Adair, L.S. (Linda), Amin, N. (Najaf), Balkau, B. (Beverley), Auvinen, J. (Juha), Beilby, J.P. (John), Bergman, R.N. (Richard N.), Bergmann, S.M. (Sven), Bertoni, A.G. (Alain G.), Blangero, J. (John), Bonnefond, A. (Amélie), Bonnycastle, L.L. (Lori), Borja, J.B. (Judith), Brage, S. (Soren), Busonero, F., Buyske, S. (Steven), Campbell, H. (Harry), Chines, P.S. (Peter), Collins, F.S. (Francis), Corre, T. (Tanguy), Smith, G.D. (George Davey), Delgado, G., Dueker, N. (Nicole), Dörr, M. (Marcus), Ebeling, T. (Tapani), Eiriksdottir, G. (Gudny), Esko, T. (Tõnu), Faul, J.D. (Jessica D.), Fu, M. (Mao), Færch, K. (Kristine), Gieger, C. (Christian), Gläser, S., Gong, J. (Jian), Gordon-Larsen, P. (Penny), Grallert, H. (Harald), Grammer, T.B. (Tanja B), Grarup, N. (Niels), Grootheest, G. (Gerard) van, Harald, K. (Kennet), Hastie, N. (Nick), Havulinna, A.S. (Aki), Hernandez, D.G. (Dena), Hindorff, L.A. (Lucia A), Hocking, L.J. (Lynne), Holmens, O.L. (Oddgeir L.), Holzapfel, C. (Christina), Hottenga, J.J. (Jouke Jan), Huang, J. (Jian), Huang, T. (Tao), Hui, J. (Jennie), Huth, C. (Cornelia), Hutri-Kähönen, N. (Nina), James, A. (Alan), Jansson, J.-O. (John-Olov), Jhun, M.A. (Min A.), Juonala, M. (Markus), Kinnunen, L. (Leena), Koistinen, H. (Heikki), Kolcic, I. (Ivana), Komulainen, P. (Pirjo), Kuusisto, J. (Johanna), Kvaløy, K. (Kirsti), Kähönen, M. (Mika), Lakka, T.A. (Timo), Launer, L.J. (Lenore), Lehne, B. (Benjamin), Lindgren, C.M. (Cecilia M.), Lorentzon, M. (Mattias), Luben, R.N. (Robert), Marre, M. (Michel), Milaneschi, Y. (Yuri), Monda, K.L. (Keri), Montgomery, G.W. (Grant W.), Moor, M.H.M. de, Mulas, A. (Antonella), Müller-Nurasyid, M. (Martina), Musk, A.W., Männikkö, R. (Reija), Männistö, S. (Satu), Narisu, N. (Narisu), Nauck, M. (Matthias), Nettleton, J.A. (Jennifer ), Nolte, I.M. (Ilja M.), Oldehinkel, A.J. (Albertine), Olden, M. (Matthias), Ong, K.K. (Ken K.), Padmanabhan, S. (Sandosh), Paternoster, L. (Lavinia), Perez, J. (Jeremiah), Perola, M. (Markus), Peters, A. (Annette), Peters, U. (Ulrike), Peyser, P.A. (Patricia A.), Prokopenko, I. (Inga), Puolijoki, H. (Hannu), Raitakari, O.T. (Olli T.), Rankinen, T. (Tuomo), Rasmussen-Torvik, L.J. (Laura J.), Rawal, R. (Rajesh), Ridker, P.M. (Paul), Rose, L.M. (Lynda), Rudan, I. (Igor), Sarti, C. (Cinzia), Sarzynski, M.A. (Mark A.), Savonen, K. (Kai), Scott, W.R. (William R.), Sanna, S. (Serena), Shuldiner, A.R. (Alan), Sidney, S. (Steve), Silbernagel, G. (Günther), Smith, B.H., Smith, J.A. (Jennifer A), Snieder, H. (Harold), Stancáková, A. (Alena), Sternfeld, B. (Barbara), Swift, A.J. (Amy), Tammelin, T. (Tuija), Tan, S.-T. (Sian-Tsung), Thorand, B. (Barbara), Thuillier, D. (Dorothee), Vandenput, L. (Liesbeth), Vestergaard, H. (Henrik), Vliet-Ostaptchouk, J.V. (Jana) van, Vohl, M.-C. (Marie-Claude), Völker, U. (Uwe), Waeber, G. (Gérard), Walker, M. (Mark), Wild, S. (Sarah), Wong, A. (Andrew), Wright, A.F. (Alan), Zillikens, M.C. (Carola), Zubair, N. (Niha), Haiman, C.A. (Christopher), LeMarchand, L. (Loic), Gyllensten, U. (Ulf), Ohlsson, C. (Claes), Hofman, A. (Albert), Rivadeneira Ramirez, F. (Fernando), Uitterlinden, A.G. (André), Perusse, L. (Louis), Wilson, J.F. (James), Hayward, C. (Caroline), Polasek, O. (Ozren), Cucca, F. (Francesco), Hveem, K. (Kristian), Hartman, C.A. (Catharina A.), Tönjes, A. (Anke), Bandinelli, S. (Stefania), Palmer, L.J. (Lyle J.), Kardia, S.L.R. (Sharon L. R.), Rauramaa, R. (Rainer), Sørensen, T.I.A. (Thorkild), Tuomilehto, J. (Jaakko), Salomaa, V. (Veikko), Penninx, B.W.J.H. (Brenda), Geus, E.J.C. (Eco) de, Boomsma, D.I. (Dorret), Lehtimäki, T. (Terho), Mangino, M. (Massimo), Laakso, M. (Markku), Bouchard, C. (Claude), Martin, N.G. (Nicholas), Kuh, D. (Diana), Liu, Y. (YongMei), Linneberg, A. (Allan), März, W. (Winfried), Strauch, K. (Konstantin), Kivimaki, M. (Mika), Harris, T.B. (Tamara), Gudnason, V. (Vilmundur), Völzke, H. (Henry), Qi, L. (Lu), Jarvelin, M.-R. (Marjo-Riitta), Chambers, J.C. (John), Kooner, J.S. (Jaspal S.), Froguel, P. (Philippe), Kooperberg, C. (Charles), Vollenweider, P. (Peter), Hallmans, G. (Göran), Hansen, T. (T.), Pedersen, O. (Oluf), Metspalu, A. (Andres), Wareham, N.J. (Nick), Langenberg, C. (Claudia), Weir, D.R. (David), Porteous, D.J. (David J.), Boerwinkle, E.A. (Eric), Chasman, D.I. (Daniel), Abecasis, G.R. (Gonçalo R.), Barroso, I.E. (Inês), McCarthy, M.I. (Mark I.), Frayling, T.M. (Timothy), O’Connell, J.R. (Jeffrey R.), Duijn, C.M. (Cornelia) van, Boehnke, M. (Michael), Heid, I.M. (Iris), Mohlke, K.L. (Karen), Strachan, D.P. (David), Fox, C.S. (Caroline), Liu, C.-T. (Ching-Ti), Hirschhorn, J.N. (Joel), Klein, R.J. (Robert J.), Johnson, A.D. (Andrew), Borecki, I.B. (Ingrid), Franks, P.W. (Paul), North, K.E. (Kari), Cupples, L.A. (Adrienne), Loos, R.J.F. (Ruth), Kilpeläinen, T.O. (Tuomas), Graff, M.J. (Maud J.L.), Scott, R.A. (Robert), Justice, A.E. (Anne), Young, K.L. (Kristin L.), Feitosa, M.F. (Mary Furlan), Barata, L. (Llilda), Winkler, T.W. (Thomas W.), Chu, A.Y. (Audrey), Mahajan, A. (Anubha), Hadley, D. (David), Xue, L. (Luting), Workalemahu, T. (Tsegaselassie), Heard-Costa, N.L. (Nancy), Hoed, M. (Marcel) den, Ahluwalia, T.S. (Tarunveer Singh), Qi, Q., Ngwa, J.S., Renström, F. (Frida), Quaye, L. (Lydia), Eicher, J.D. (John D.), Hayes, J.E. (James E.), Cornelis, M. (Marilyn), Kutalik, Z. (Zoltán), Lim, E. (Elise), Luan, J. (Jian'An), Huffman, J.E. (Jennifer), Zhang, W. (Weihua), Zhao, W. (Wei), Griffin, P.J. (Paula J.), Haller, T. (Toomas), Ahmad, S. (Shafqat), Marques-Vidal, P. (Pedro), Bien, S. (Stephanie), Yengo, L. (Loic), Teumer, A. (Alexander), Smith, A.V. (Albert Vernon), Kumari, M. (Meena), Harder, M.N. (Marie Neergaard), Justesen, J.M. (Johanne M.), Kleber, M.E. (Marcus), Hollensted, M. (Mette), Lohman, K. (Kurt), Rivera, N.V. (Natalia), Whitfield, J.B. (John B.), Zhao, J.H. (Jing Hua), Stringham, H.M. (Heather), Lyytikäinen, L.-P. (Leo-Pekka), Huppertz, C. (Charlotte), Willemsen, G.A.H.M. (Gonneke), Peyrot, W.J. (Wouter ), Wu, Y. (Ying), Kristiansson, K. (Kati), Demirkan, A. (Ayşe), Fornage, M. (Myriam), Hassinen, M. (Maija), Bielak, L.F. (Lawrence F.), Cadby, G. (Gemma), Tanaka, T. (Toshiko), Mägi, R. (Reedik), Most, P.J. (Peter) van der, Jackson, A.U. (Anne), Bragg-Gresham, J.L. (Jennifer L.), Vitart, V. (Veronique), Marten, J. (Jonathan), Navarro, P. (Pau), Bellis, C. (Claire), Pasko, D. (Dorota), Johansson, Å. (Åsa), Snitker, S. (Soren), Cheng, Y.-C. (Yu-Ching), Eriksson, J. (Joel), Lim, U. (Unhee), Aadahl, M. (Mette), Adair, L.S. (Linda), Amin, N. (Najaf), Balkau, B. (Beverley), Auvinen, J. (Juha), Beilby, J.P. (John), Bergman, R.N. (Richard N.), Bergmann, S.M. (Sven), Bertoni, A.G. (Alain G.), Blangero, J. (John), Bonnefond, A. (Amélie), Bonnycastle, L.L. (Lori), Borja, J.B. (Judith), Brage, S. (Soren), Busonero, F., Buyske, S. (Steven), Campbell, H. (Harry), Chines, P.S. (Peter), Collins, F.S. (Francis), Corre, T. (Tanguy), Smith, G.D. (George Davey), Delgado, G., Dueker, N. (Nicole), Dörr, M. (Marcus), Ebeling, T. (Tapani), Eiriksdottir, G. (Gudny), Esko, T. (Tõnu), Faul, J.D. (Jessica D.), Fu, M. (Mao), Færch, K. (Kristine), Gieger, C. (Christian), Gläser, S., Gong, J. (Jian), Gordon-Larsen, P. (Penny), Grallert, H. (Harald), Grammer, T.B. (Tanja B), Grarup, N. (Niels), Grootheest, G. (Gerard) van, Harald, K. (Kennet), Hastie, N. (Nick), Havulinna, A.S. (Aki), Hernandez, D.G. (Dena), Hindorff, L.A. (Lucia A), Hocking, L.J. (Lynne), Holmens, O.L. (Oddgeir L.), Holzapfel, C. (Christina), Hottenga, J.J. (Jouke Jan), Huang, J. (Jian), Huang, T. (Tao), Hui, J. (Jennie), Huth, C. (Cornelia), Hutri-Kähönen, N. (Nina), James, A. (Alan), Jansson, J.-O. (John-Olov), Jhun, M.A. (Min A.), Juonala, M. (Markus), Kinnunen, L. (Leena), Koistinen, H. (Heikki), Kolcic, I. (Ivana), Komulainen, P. (Pirjo), Kuusisto, J. (Johanna), Kvaløy, K. (Kirsti), Kähönen, M. (Mika), Lakka, T.A. (Timo), Launer, L.J. (Lenore), Lehne, B. (Benjamin), Lindgren, C.M. (Cecilia M.), Lorentzon, M. (Mattias), Luben, R.N. (Robert), Marre, M. (Michel), Milaneschi, Y. (Yuri), Monda, K.L. (Keri), Montgomery, G.W. (Grant W.), Moor, M.H.M. de, Mulas, A. (Antonella), Müller-Nurasyid, M. (Martina), Musk, A.W., Männikkö, R. (Reija), Männistö, S. (Satu), Narisu, N. (Narisu), Nauck, M. (Matthias), Nettleton, J.A. (Jennifer ), Nolte, I.M. (Ilja M.), Oldehinkel, A.J. (Albertine), Olden, M. (Matthias), Ong, K.K. (Ken K.), Padmanabhan, S. (Sandosh), Paternoster, L. (Lavinia), Perez, J. (Jeremiah), Perola, M. (Markus), Peters, A. (Annette), Peters, U. (Ulrike), Peyser, P.A. (Patricia A.), Prokopenko, I. (Inga), Puolijoki, H. (Hannu), Raitakari, O.T. (Olli T.), Rankinen, T. (Tuomo), Rasmussen-Torvik, L.J. (Laura J.), Rawal, R. (Rajesh), Ridker, P.M. (Paul), Rose, L.M. (Lynda), Rudan, I. (Igor), Sarti, C. (Cinzia), Sarzynski, M.A. (Mark A.), Savonen, K. (Kai), Scott, W.R. (William R.), Sanna, S. (Serena), Shuldiner, A.R. (Alan), Sidney, S. (Steve), Silbernagel, G. (Günther), Smith, B.H., Smith, J.A. (Jennifer A), Snieder, H. (Harold), Stancáková, A. (Alena), Sternfeld, B. (Barbara), Swift, A.J. (Amy), Tammelin, T. (Tuija), Tan, S.-T. (Sian-Tsung), Thorand, B. (Barbara), Thuillier, D. (Dorothee), Vandenput, L. (Liesbeth), Vestergaard, H. (Henrik), Vliet-Ostaptchouk, J.V. (Jana) van, Vohl, M.-C. (Marie-Claude), Völker, U. (Uwe), Waeber, G. (Gérard), Walker, M. (Mark), Wild, S. (Sarah), Wong, A. (Andrew), Wright, A.F. (Alan), Zillikens, M.C. (Carola), Zubair, N. (Niha), Haiman, C.A. (Christopher), LeMarchand, L. (Loic), Gyllensten, U. (Ulf), Ohlsson, C. (Claes), Hofman, A. (Albert), Rivadeneira Ramirez, F. (Fernando), Uitterlinden, A.G. (André), Perusse, L. (Louis), Wilson, J.F. (James), Hayward, C. (Caroline), Polasek, O. (Ozren), Cucca, F. (Francesco), Hveem, K. (Kristian), Hartman, C.A. (Catharina A.), Tönjes, A. (Anke), Bandinelli, S. (Stefania), Palmer, L.J. (Lyle J.), Kardia, S.L.R. (Sharon L. R.), Rauramaa, R. (Rainer), Sørensen, T.I.A. (Thorkild), Tuomilehto, J. (Jaakko), Salomaa, V. (Veikko), Penninx, B.W.J.H. (Brenda), Geus, E.J.C. (Eco) de, Boomsma, D.I. (Dorret), Lehtimäki, T. (Terho), Mangino, M. (Massimo), Laakso, M. (Markku), Bouchard, C. (Claude), Martin, N.G. (Nicholas), Kuh, D. (Diana), Liu, Y. (YongMei), Linneberg, A. (Allan), März, W. (Winfried), Strauch, K. (Konstantin), Kivimaki, M. (Mika), Harris, T.B. (Tamara), Gudnason, V. (Vilmundur), Völzke, H. (Henry), Qi, L. (Lu), Jarvelin, M.-R. (Marjo-Riitta), Chambers, J.C. (John), Kooner, J.S. (Jaspal S.), Froguel, P. (Philippe), Kooperberg, C. (Charles), Vollenweider, P. (Peter), Hallmans, G. (Göran), Hansen, T. (T.), Pedersen, O. (Oluf), Metspalu, A. (Andres), Wareham, N.J. (Nick), Langenberg, C. (Claudia), Weir, D.R. (David), Porteous, D.J. (David J.), Boerwinkle, E.A. (Eric), Chasman, D.I. (Daniel), Abecasis, G.R. (Gonçalo R.), Barroso, I.E. (Inês), McCarthy, M.I. (Mark I.), Frayling, T.M. (Timothy), O’Connell, J.R. (Jeffrey R.), Duijn, C.M. (Cornelia) van, Boehnke, M. (Michael), Heid, I.M. (Iris), Mohlke, K.L. (Karen), Strachan, D.P. (David), Fox, C.S. (Caroline), Liu, C.-T. (Ching-Ti), Hirschhorn, J.N. (Joel), Klein, R.J. (Robert J.), Johnson, A.D. (Andrew), Borecki, I.B. (Ingrid), Franks, P.W. (Paul), North, K.E. (Kari), Cupples, L.A. (Adrienne), Loos, R.J.F. (Ruth), and Kilpeläinen, T.O. (Tuomas)
Abstract: Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by ~30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.
Published: 2017
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3. Genome-wide physical activity interactions in adiposity:a meta-analysis of 200,452 adults

Author: Graff, M. (Mariaelisa), Scott, R. A. (Robert A.), Justice, A. E. (Anne E.), Young, K. L. (Kristin L.), Feitosa, M. F. (Mary F.), Barata, L. (Llilda), Winkler, T. W. (Thomas W.), Chu, A. Y. (Audrey Y.), Mahajan, A. (Anubha), Hadley, D. (David), Xue, L. (Luting), Workalemahu, T. (Tsegaselassie), Heard-Costa, N. L. (Nancy L.), den Hoed, M. (Marcel), Ahluwalia, T. S. (Tarunveer S.), Qi, Q. (Qibin), Ngwa, J. S. (Julius S.), Renstrom, F. (Frida), Quaye, L. (Lydia), Eicher, J. D. (John D.), Hayes, J. E. (James E.), Cornelis, M. (Marilyn), Kutalik, Z. (Zoltan), Lim, E. (Elise), Luan, J. (Jian'an), Huffman, J. E. (Jennifer E.), Zhang, W. (Weihua), Zhao, W. (Wei), Griffin, P. J. (Paula J.), Haller, T. (Toomas), Ahmad, S. (Shafqat), Marques-Vidal, P. M. (Pedro M.), Bien, S. (Stephanie), Yengo, L. (Loic), Teumer, A. (Alexander), Smith, A. V. (Albert Vernon), Kumari, M. (Meena), Harder, M. N. (Marie Neergaard), Justesen, J. M. (Johanne Marie), Kleber, M. E. (Marcus E.), Hollensted, M. (Mette), Lohman, K. (Kurt), Rivera, N. V. (Natalia V.), Whitfield, J. B. (John B.), Zhao, J. H. (Jing Hua), Stringham, H. M. (Heather M.), Lyytikainen, L.-P. (Leo-Pekka), Huppertz, C. (Charlotte), Willemsen, G. (Gonneke), Peyrot, W. J. (Wouter J.), Wu, Y. (Ying), Kristiansson, K. (Kati), Demirkan, A. (Ayse), Fornage, M. (Myriam), Hassinen, M. (Maija), Bielak, L. F. (Lawrence F.), Cadby, G. (Gemma), Tanaka, T. (Toshiko), Magl, R. (Reedlk), Van der Most, P. J. (Peter J.), Jackson, A. U. (Anne U.), Bragg-Gresham, J. L. (Jennifer L.), Vitart, V. (Veronique), Marten, J. (Jonathan), Navarro, P. (Pau), Bellis, C. (Claire), Pasko, D. (Dorota), Johansson, A. (Asa), Snitker, S. (Soren), Cheng, Y.-C. (Yu-Ching), Eriksson, J. (Joel), Lim, U. (Unhee), Aadahl, M. (Mette), Adair, L. S. (Linda S.), Amin, N. (Najaf), Balkau, B. (Beverley), Auvinen, J. (Juha), Beilby, J. (John), Bergman, R. N. (Richard N.), Bergmann, S. (Sven), Bertoni, A. G. (Alain G.), Blangero, J. (John), Bonnefond, A. (Amelle), Bonnycastle, L. L. (Lori L.), Borja, J. B. (Judith B.), Brage, S. (Soren), Busonero, F. (Fabio), Buyske, S. (Steve), Campbell, H. (Harry), Chines, P. S. (Peter S.), Collins, F. S. (Francis S.), Corre, T. (Tanguy), Smith, G. D. (George Davey), Delgado, G. E. (Graciela E.), Dueker, N. (Nicole), Doerr, M. (Marcus), Ebeling, T. (Tapani), Eiriksdottir, G. (Gudny), Esko, T. (Tonu), Faul, J. D. (Jessica D.), Fu, M. (Mao), Faerch, K. (Kristine), Gieger, C. (Christian), Glaeser, S. (Sven), Gong, J. (Jian), Gordon-Larsen, P. (Penny), Grallert, H. (Harald), Grammer, T. B. (Tanja B.), Grarup, N. (Niels), van Grootheest, G. (Gerard), Harald, K. (Kennet), Hastie, N. D. (Nicholas D.), Havulinna, A. S. (Aki S.), Hernandez, D. (Dena), Hindorff, L. (Lucia), Hocking, L. J. (Lynne J.), Holmens, O. L. (Oddgeir L.), Holzapfel, C. (Christina), Hottenga, J. J. (Jouke Jan), Huang, J. (Jie), Huang, T. (Tao), Hui, J. (Jennie), Huth, C. (Cornelia), Hutri-Kahonen, N. (Nina), James, A. L. (Alan L.), Jansson, J.-O. (John-Olov), Jhun, M. A. (Min A.), Juonala, M. (Markus), Kinnunen, L. (Leena), Koistinen, H. A. (Heikki A.), Kolcic, I. (Ivana), Komulainen, P. (Pirjo), Kuusisto, J. (Johanna), Kvaloy, K. (Kirsti), Kahonen, M. (Mika), Lakka, T. A. (Timo A.), Launer, L. J. (Lenore J.), Lehne, B. (Benjamin), Lindgren, C. M. (Cecilia M.), Lorentzon, M. (Mattias), Luben, R. (Robert), Marre, M. (Michel), Milaneschi, Y. (Yuri), Monda, K. L. (Keri L.), Montgomery, G. W. (Grant W.), De Moor, M. H. (Marleen H. M.), Mulas, A. (Antonella), Mueller-Nurasyid, M. (Martina), Musk, A. W. (A. W.), Mannikko, R. (Reija), Mannisto, S. (Satu), Narisu, N. (Narisu), Nauck, M. (Matthias), Nettleton, J. A. (Jennifer A.), Nolte, I. M. (Ilja M.), Oldehinkel, A. J. (Albertine J.), Olden, M. (Matthias), Ong, K. K. (Ken K.), Padmanabhan, S. (Sandosh), Paternoster, L. (Lavinia), Perez, J. (Jeremiah), Perola, M. (Markus), Peters, A. (Annette), Peters, U. (Ulrike), Peyser, P. A. (Patricia A.), Prokopenko, I. (Inga), Puolijoki, H. (Hannu), Raitakari, O. T. (Olli T.), Rankinen, T. (Tuomo), Rasmussen-Torvik, L. J. (Laura J.), Rawal, R. (Rajesh), Ridker, P. M. (Paul M.), Rose, L. M. (Lynda M.), Rudan, I. (Igor), Sarti, C. (Cinzia), Sarzynski, M. A. (Mark A.), Savonen, K. (Kai), Scott, W. R. (William R.), Sanna, S. (Serena), Shuldiner, A. R. (Alan R.), Sidney, S. (Steve), Silbernagel, G. (Guenther), Smith, B. H. (Blair H.), Smith, J. A. (Jennifer A.), Snieder, H. (Harold), Stancakova, A. (Alena), Sternfeld, B. (Barbara), Swift, A. J. (Amy J.), Tammelin, T. (Tuija), Tan, S.-T. (Sian-Tsung), Thorand, B. (Barbara), Thuillier, D. (Dorothee), Vandenput, L. (Liesbeth), Vestergaard, H. (Henrik), van Vliet-Ostaptchouk, J. V. (Jana V.), Vohl, M.-C. (Marie-Claude), Voelker, U. (Uwe), Waeber, G. (Gerard), Walker, M. (Mark), Wild, S. (Sarah), Wong, A. (Andrew), Wright, A. F. (Alan F.), Zillikens, M. C. (M. Carola), Zubair, N. (Niha), Haiman, C. A. (Christopher A.), Lemarchand, L. (Loic), Gyllensten, U. (Ulf), Ohlsson, C. (Claes), Hofman, A. (Albert), Rivadeneira, F. (Fernando), Uitterlinden, A. G. (Andre G.), Perusse, L. (Louis), Wilson, J. F. (James F.), Hayward, C. (Caroline), Polasek, O. (Ozren), Cucca, F. (Francesco), Hveem, K. (Kristian), Hartman, C. A. (Catharina A.), Toenjes, A. (Anke), Bandinelli, S. (Stefania), Palmer, L. J. (Lyle J.), Kardia, S. L. (Sharon L. R.), Rauramaa, R. (Rainer), Sorensen, T. I. (Thorkild I. A.), Tuomilehto, J. (Jaakko), Salomaa, V. (Veikko), Penninx, B. W. (Brenda W. J. H.), de Geus, E. J. (Eco J. C.), Boomsma, D. I. (Dorret I.), Lehtimaki, T. (Terho), Mangino, M. (Massimo), Laakso, M. (Markku), Bouchard, C. (Claude), Martin, N. G. (Nicholas G.), Kuh, D. (Diana), Liu, Y. (Yongmei), Linneberg, A. (Allan), Maerz, W. (Winfried), Strauch, K. (Konstantin), Kivimaki, M. (Mika), Harris, T. B. (Tamara B.), Gudnason, V. (Vilmundur), Voelzke, H. (Henry), Qi, L. (Lu), Jarvelin, M.-R. (Marjo-Riitta), Chambers, J. C. (John C.), Kooner, J. S. (Jaspal S.), Froguel, P. (Philippe), Kooperberg, C. (Charles), Vollenweider, P. (Peter), Hallmans, G. (Goran), Hansen, T. (Torben), Pedersen, O. (Oluf), Metspalu, A. (Andres), Wareham, N. J. (Nicholas J.), Langenberg, C. (Claudia), Weir, D. R. (David R.), Porteous, D. J. (David J.), Boerwinkle, E. (Eric), Chasman, D. I. (Daniel I.), Abecasis, G. R. (Goncalo R.), Barroso, I. (Ines), McCarthy, M. I. (Mark I.), Frayling, T. M. (Timothy M.), O'Connell, J. R. (Jeffrey R.), van Duijn, C. M. (Cornelia M.), Boehnke, M. (Michael), Heid, I. M. (Iris M.), Mohlke, K. L. (Karen L.), Strachan, D. P. (David P.), Fox, C. S. (Caroline S.), Liu, C.-T. (Ching-Ti), Hirschhorn, J. N. (Joel N.), Klein, R. J. (Robert J.), Johnson, A. D. (Andrew D.), Borecki, I. B. (Ingrid B.), Franks, P. W. (Paul W.), North, K. E. (Kari E.), Cupples, L. A. (L. Adrienne), Loos, R. J. (Ruth J. F.), Kilpelainen, T. O. (Tuomas O.), Graff, M. (Mariaelisa), Scott, R. A. (Robert A.), Justice, A. E. (Anne E.), Young, K. L. (Kristin L.), Feitosa, M. F. (Mary F.), Barata, L. (Llilda), Winkler, T. W. (Thomas W.), Chu, A. Y. (Audrey Y.), Mahajan, A. (Anubha), Hadley, D. (David), Xue, L. (Luting), Workalemahu, T. (Tsegaselassie), Heard-Costa, N. L. (Nancy L.), den Hoed, M. (Marcel), Ahluwalia, T. S. (Tarunveer S.), Qi, Q. (Qibin), Ngwa, J. S. (Julius S.), Renstrom, F. (Frida), Quaye, L. (Lydia), Eicher, J. D. (John D.), Hayes, J. E. (James E.), Cornelis, M. (Marilyn), Kutalik, Z. (Zoltan), Lim, E. (Elise), Luan, J. (Jian'an), Huffman, J. E. (Jennifer E.), Zhang, W. (Weihua), Zhao, W. (Wei), Griffin, P. J. (Paula J.), Haller, T. (Toomas), Ahmad, S. (Shafqat), Marques-Vidal, P. M. (Pedro M.), Bien, S. (Stephanie), Yengo, L. (Loic), Teumer, A. (Alexander), Smith, A. V. (Albert Vernon), Kumari, M. (Meena), Harder, M. N. (Marie Neergaard), Justesen, J. M. (Johanne Marie), Kleber, M. E. (Marcus E.), Hollensted, M. (Mette), Lohman, K. (Kurt), Rivera, N. V. (Natalia V.), Whitfield, J. B. (John B.), Zhao, J. H. (Jing Hua), Stringham, H. M. (Heather M.), Lyytikainen, L.-P. (Leo-Pekka), Huppertz, C. (Charlotte), Willemsen, G. (Gonneke), Peyrot, W. J. (Wouter J.), Wu, Y. (Ying), Kristiansson, K. (Kati), Demirkan, A. (Ayse), Fornage, M. (Myriam), Hassinen, M. (Maija), Bielak, L. F. (Lawrence F.), Cadby, G. (Gemma), Tanaka, T. (Toshiko), Magl, R. (Reedlk), Van der Most, P. J. (Peter J.), Jackson, A. U. (Anne U.), Bragg-Gresham, J. L. (Jennifer L.), Vitart, V. (Veronique), Marten, J. (Jonathan), Navarro, P. (Pau), Bellis, C. (Claire), Pasko, D. (Dorota), Johansson, A. (Asa), Snitker, S. (Soren), Cheng, Y.-C. (Yu-Ching), Eriksson, J. (Joel), Lim, U. (Unhee), Aadahl, M. (Mette), Adair, L. S. (Linda S.), Amin, N. (Najaf), Balkau, B. (Beverley), Auvinen, J. (Juha), Beilby, J. (John), Bergman, R. N. (Richard N.), Bergmann, S. (Sven), Bertoni, A. G. (Alain G.), Blangero, J. (John), Bonnefond, A. (Amelle), Bonnycastle, L. L. (Lori L.), Borja, J. B. (Judith B.), Brage, S. (Soren), Busonero, F. (Fabio), Buyske, S. (Steve), Campbell, H. (Harry), Chines, P. S. (Peter S.), Collins, F. S. (Francis S.), Corre, T. (Tanguy), Smith, G. D. (George Davey), Delgado, G. E. (Graciela E.), Dueker, N. (Nicole), Doerr, M. (Marcus), Ebeling, T. (Tapani), Eiriksdottir, G. (Gudny), Esko, T. (Tonu), Faul, J. D. (Jessica D.), Fu, M. (Mao), Faerch, K. (Kristine), Gieger, C. (Christian), Glaeser, S. (Sven), Gong, J. (Jian), Gordon-Larsen, P. (Penny), Grallert, H. (Harald), Grammer, T. B. (Tanja B.), Grarup, N. (Niels), van Grootheest, G. (Gerard), Harald, K. (Kennet), Hastie, N. D. (Nicholas D.), Havulinna, A. S. (Aki S.), Hernandez, D. (Dena), Hindorff, L. (Lucia), Hocking, L. J. (Lynne J.), Holmens, O. L. (Oddgeir L.), Holzapfel, C. (Christina), Hottenga, J. J. (Jouke Jan), Huang, J. (Jie), Huang, T. (Tao), Hui, J. (Jennie), Huth, C. (Cornelia), Hutri-Kahonen, N. (Nina), James, A. L. (Alan L.), Jansson, J.-O. (John-Olov), Jhun, M. A. (Min A.), Juonala, M. (Markus), Kinnunen, L. (Leena), Koistinen, H. A. (Heikki A.), Kolcic, I. (Ivana), Komulainen, P. (Pirjo), Kuusisto, J. (Johanna), Kvaloy, K. (Kirsti), Kahonen, M. (Mika), Lakka, T. A. (Timo A.), Launer, L. J. (Lenore J.), Lehne, B. (Benjamin), Lindgren, C. M. (Cecilia M.), Lorentzon, M. (Mattias), Luben, R. (Robert), Marre, M. (Michel), Milaneschi, Y. (Yuri), Monda, K. L. (Keri L.), Montgomery, G. W. (Grant W.), De Moor, M. H. (Marleen H. M.), Mulas, A. (Antonella), Mueller-Nurasyid, M. (Martina), Musk, A. W. (A. W.), Mannikko, R. (Reija), Mannisto, S. (Satu), Narisu, N. (Narisu), Nauck, M. (Matthias), Nettleton, J. A. (Jennifer A.), Nolte, I. M. (Ilja M.), Oldehinkel, A. J. (Albertine J.), Olden, M. (Matthias), Ong, K. K. (Ken K.), Padmanabhan, S. (Sandosh), Paternoster, L. (Lavinia), Perez, J. (Jeremiah), Perola, M. (Markus), Peters, A. (Annette), Peters, U. (Ulrike), Peyser, P. A. (Patricia A.), Prokopenko, I. (Inga), Puolijoki, H. (Hannu), Raitakari, O. T. (Olli T.), Rankinen, T. (Tuomo), Rasmussen-Torvik, L. J. (Laura J.), Rawal, R. (Rajesh), Ridker, P. M. (Paul M.), Rose, L. M. (Lynda M.), Rudan, I. (Igor), Sarti, C. (Cinzia), Sarzynski, M. A. (Mark A.), Savonen, K. (Kai), Scott, W. R. (William R.), Sanna, S. (Serena), Shuldiner, A. R. (Alan R.), Sidney, S. (Steve), Silbernagel, G. (Guenther), Smith, B. H. (Blair H.), Smith, J. A. (Jennifer A.), Snieder, H. (Harold), Stancakova, A. (Alena), Sternfeld, B. (Barbara), Swift, A. J. (Amy J.), Tammelin, T. (Tuija), Tan, S.-T. (Sian-Tsung), Thorand, B. (Barbara), Thuillier, D. (Dorothee), Vandenput, L. (Liesbeth), Vestergaard, H. (Henrik), van Vliet-Ostaptchouk, J. V. (Jana V.), Vohl, M.-C. (Marie-Claude), Voelker, U. (Uwe), Waeber, G. (Gerard), Walker, M. (Mark), Wild, S. (Sarah), Wong, A. (Andrew), Wright, A. F. (Alan F.), Zillikens, M. C. (M. Carola), Zubair, N. (Niha), Haiman, C. A. (Christopher A.), Lemarchand, L. (Loic), Gyllensten, U. (Ulf), Ohlsson, C. (Claes), Hofman, A. (Albert), Rivadeneira, F. (Fernando), Uitterlinden, A. G. (Andre G.), Perusse, L. (Louis), Wilson, J. F. (James F.), Hayward, C. (Caroline), Polasek, O. (Ozren), Cucca, F. (Francesco), Hveem, K. (Kristian), Hartman, C. A. (Catharina A.), Toenjes, A. (Anke), Bandinelli, S. (Stefania), Palmer, L. J. (Lyle J.), Kardia, S. L. (Sharon L. R.), Rauramaa, R. (Rainer), Sorensen, T. I. (Thorkild I. A.), Tuomilehto, J. (Jaakko), Salomaa, V. (Veikko), Penninx, B. W. (Brenda W. J. H.), de Geus, E. J. (Eco J. C.), Boomsma, D. I. (Dorret I.), Lehtimaki, T. (Terho), Mangino, M. (Massimo), Laakso, M. (Markku), Bouchard, C. (Claude), Martin, N. G. (Nicholas G.), Kuh, D. (Diana), Liu, Y. (Yongmei), Linneberg, A. (Allan), Maerz, W. (Winfried), Strauch, K. (Konstantin), Kivimaki, M. (Mika), Harris, T. B. (Tamara B.), Gudnason, V. (Vilmundur), Voelzke, H. (Henry), Qi, L. (Lu), Jarvelin, M.-R. (Marjo-Riitta), Chambers, J. C. (John C.), Kooner, J. S. (Jaspal S.), Froguel, P. (Philippe), Kooperberg, C. (Charles), Vollenweider, P. (Peter), Hallmans, G. (Goran), Hansen, T. (Torben), Pedersen, O. (Oluf), Metspalu, A. (Andres), Wareham, N. J. (Nicholas J.), Langenberg, C. (Claudia), Weir, D. R. (David R.), Porteous, D. J. (David J.), Boerwinkle, E. (Eric), Chasman, D. I. (Daniel I.), Abecasis, G. R. (Goncalo R.), Barroso, I. (Ines), McCarthy, M. I. (Mark I.), Frayling, T. M. (Timothy M.), O'Connell, J. R. (Jeffrey R.), van Duijn, C. M. (Cornelia M.), Boehnke, M. (Michael), Heid, I. M. (Iris M.), Mohlke, K. L. (Karen L.), Strachan, D. P. (David P.), Fox, C. S. (Caroline S.), Liu, C.-T. (Ching-Ti), Hirschhorn, J. N. (Joel N.), Klein, R. J. (Robert J.), Johnson, A. D. (Andrew D.), Borecki, I. B. (Ingrid B.), Franks, P. W. (Paul W.), North, K. E. (Kari E.), Cupples, L. A. (L. Adrienne), Loos, R. J. (Ruth J. F.), and Kilpelainen, T. O. (Tuomas O.)
Abstract: Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by ~30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.
Published: 2017

4. Physical activity attenuates the influence of FTO variants on obesity risk: A meta-analysis of 218,166 adults and 19,268 children

Author: Kilpeläinen, T.O. (Tuomas), Qi, L. (Lu), Brage, S. (Soren), Sharp, S.J. (Stephen), Sonestedt, E. (Emily), Demerath, E.W. (Ellen), Ahmad, T. (Tariq), Mora, S. (Samia), Kaakinen, M. (Marika), Sandholt, C. (Camilla), Holzapfel, C. (Christina), Autenrieth, C.S. (Christine), Hyppönen, E. (Elina), Cauchi, S. (Stephane), He, M. (Meian), Kutalik, Z. (Zoltán), Kumari, M. (Meena), Stancáková, A. (Alena), Meidtner, K. (Karina), Balkau, B. (Beverley), Tan, J.T. (Jonathan), Mangino, M. (Massimo), Timpson, N.J. (Nicholas), Song, Y. (Yiqing), Zillikens, M.C. (Carola), Jablonski, K.A. (Kathleen), Garcia, M. (Melissa), Johansson, S. (Stefan), Bragg-Gresham, J.L. (Jennifer L.), Wu, Y. (Ying), Vliet-Ostaptchouk, J.V. (Jana) van, Onland-Moret, N.C. (Charlotte), Zimmermann, E. (Esther), Rivera, N.V. (Natalia), Tanaka, T. (Toshiko), Stringham, H.M. (Heather), Silbernagel, G. (Günther), Kanoni, S. (Stavroula), Feitosa, M.F. (Mary Furlan), Snitker, S. (Soren), Ruiz, J.R. (Jonatan), Metter, J. (Jeffery), Larrad, M.T.M., Atalay, M. (Mustafa), Hakanen, M. (Maarit), Amin, N. (Najaf), Cavalcanti-Proença, C. (Christine), Grøntved, A. (Anders), Hallmans, G. (Göran), Jansson, J.O., Kuusisto, J. (Johanna), Kähönen, M. (Mika), Lutsey, P.L. (Pamela), Nolan, J.J. (John), Palla, L. (Luigi), Pedersen, O. (Oluf), Pérusse, L. (Louis), Renström, F. (Frida), Scott, R.A. (Robert), Shungin, D. (Dmitry), Sovio, U. (Ulla), Tammelin, T.H. (Tuija), Rönnemaa, T. (Tapani), Lakka, T.A. (Timo), Uusitupa, M. (Matti), Rios, M.S., Ferrucci, L. (Luigi), Bouchard, C. (Claude), Meirhaeghe, A. (Aline), Fu, M. (Mao), Walker, M. (Mark), Borecki, I.B. (Ingrid), Dedoussis, G.V. (George), Fritsche, A. (Andreas), Ohlsson, C. (Claes), Boehnke, M. (Michael), Bandinelli, S. (Stefania), Tikka-Kleemola, P. (Päivi), Lawlor, D.A. (Debbie), Gudnason, V. (Vilmundur), Harris, T.B. (Tamara), Sørensen, T.I.A. (Thorkild), Mohlke, K.L. (Karen), Hofman, A. (Albert), Uitterlinden, A.G. (André), Tuomilehto, J. (Jaakko), Lehtimäki, T. (Terho), Raitakari, O. (Olli), Isomaa, B. (Bo), Njolstad, P. (Pal), Florez, J.C. (Jose), Liu, S. (Simin), Ness, A.R. (Andrew), Spector, T.D. (Timothy), Tai, E.S. (Shyong), Froguel, P. (Philippe), Boeing, H. (Heiner), Laakso, M. (Markku), Marmot, M. (Michael), Bergmann, S.M. (Sven), Power, C. (Chris), Khaw, K.-T., Chasman, D.I. (Daniel), Ridker, P.M. (Paul), Hansen, T. (Torben), Monda, K.L. (Keri), Illig, T. (Thomas), Järvelin, M.R., Wareham, N.J. (Nick), Ebrahim, S. (Shanil), Hu, F.B. (Frank), Groop, L. (Leif), Orho-Melander, M. (Marju), Ekelund, U. (Ulf), Franks, P.W. (Paul), Loos, R.J.F. (Ruth), Kilpeläinen, T.O. (Tuomas), Qi, L. (Lu), Brage, S. (Soren), Sharp, S.J. (Stephen), Sonestedt, E. (Emily), Demerath, E.W. (Ellen), Ahmad, T. (Tariq), Mora, S. (Samia), Kaakinen, M. (Marika), Sandholt, C. (Camilla), Holzapfel, C. (Christina), Autenrieth, C.S. (Christine), Hyppönen, E. (Elina), Cauchi, S. (Stephane), He, M. (Meian), Kutalik, Z. (Zoltán), Kumari, M. (Meena), Stancáková, A. (Alena), Meidtner, K. (Karina), Balkau, B. (Beverley), Tan, J.T. (Jonathan), Mangino, M. (Massimo), Timpson, N.J. (Nicholas), Song, Y. (Yiqing), Zillikens, M.C. (Carola), Jablonski, K.A. (Kathleen), Garcia, M. (Melissa), Johansson, S. (Stefan), Bragg-Gresham, J.L. (Jennifer L.), Wu, Y. (Ying), Vliet-Ostaptchouk, J.V. (Jana) van, Onland-Moret, N.C. (Charlotte), Zimmermann, E. (Esther), Rivera, N.V. (Natalia), Tanaka, T. (Toshiko), Stringham, H.M. (Heather), Silbernagel, G. (Günther), Kanoni, S. (Stavroula), Feitosa, M.F. (Mary Furlan), Snitker, S. (Soren), Ruiz, J.R. (Jonatan), Metter, J. (Jeffery), Larrad, M.T.M., Atalay, M. (Mustafa), Hakanen, M. (Maarit), Amin, N. (Najaf), Cavalcanti-Proença, C. (Christine), Grøntved, A. (Anders), Hallmans, G. (Göran), Jansson, J.O., Kuusisto, J. (Johanna), Kähönen, M. (Mika), Lutsey, P.L. (Pamela), Nolan, J.J. (John), Palla, L. (Luigi), Pedersen, O. (Oluf), Pérusse, L. (Louis), Renström, F. (Frida), Scott, R.A. (Robert), Shungin, D. (Dmitry), Sovio, U. (Ulla), Tammelin, T.H. (Tuija), Rönnemaa, T. (Tapani), Lakka, T.A. (Timo), Uusitupa, M. (Matti), Rios, M.S., Ferrucci, L. (Luigi), Bouchard, C. (Claude), Meirhaeghe, A. (Aline), Fu, M. (Mao), Walker, M. (Mark), Borecki, I.B. (Ingrid), Dedoussis, G.V. (George), Fritsche, A. (Andreas), Ohlsson, C. (Claes), Boehnke, M. (Michael), Bandinelli, S. (Stefania), Tikka-Kleemola, P. (Päivi), Lawlor, D.A. (Debbie), Gudnason, V. (Vilmundur), Harris, T.B. (Tamara), Sørensen, T.I.A. (Thorkild), Mohlke, K.L. (Karen), Hofman, A. (Albert), Uitterlinden, A.G. (André), Tuomilehto, J. (Jaakko), Lehtimäki, T. (Terho), Raitakari, O. (Olli), Isomaa, B. (Bo), Njolstad, P. (Pal), Florez, J.C. (Jose), Liu, S. (Simin), Ness, A.R. (Andrew), Spector, T.D. (Timothy), Tai, E.S. (Shyong), Froguel, P. (Philippe), Boeing, H. (Heiner), Laakso, M. (Markku), Marmot, M. (Michael), Bergmann, S.M. (Sven), Power, C. (Chris), Khaw, K.-T., Chasman, D.I. (Daniel), Ridker, P.M. (Paul), Hansen, T. (Torben), Monda, K.L. (Keri), Illig, T. (Thomas), Järvelin, M.R., Wareham, N.J. (Nick), Ebrahim, S. (Shanil), Hu, F.B. (Frank), Groop, L. (Leif), Orho-Melander, M. (Marju), Ekelund, U. (Ulf), Franks, P.W. (Paul), and Loos, R.J.F. (Ruth)
Abstract: Background: The FTO gene harbors the strongest known susceptibility locus for obesity. While many individual studies have suggested that physical activity (PA) may attenuate the effect of FTO on obesity risk, other studies have not been able to confirm this interaction. To confirm or refute unambiguously whether PA attenuates the association of FTO with obesity risk, we meta-analyzed data from 45 studies of adults (n = 218,166) and nine studies of children and adolescents (n = 19,268). Methods and Findings: All studies identified to have data on the FTO rs9939609 variant (or any proxy [r2>0.8]) and PA were invited to participate, regardless of ethnicity or age of the participants. PA was standardized by categorizing it into a dichotomous variable (physically inactive versus active) in each study. Overall, 25% of adults and 13% of children were categorized as inactive. Interaction analyses were performed within each study by including the FTO×PA interaction term in an additive model, adjusting for age and sex. Subsequently, random effects meta-analysis was used to pool the interaction terms. In adults, the minor (A-) allele of rs9939609 increased the odds of obesity by 1.23-fold/allele (95% CI 1.20-1.26), but PA attenuated this effect (pinteraction= 0.001). More specifically, the minor allele of rs9939609 increased the odds of obesity less in the physically active group (odds ratio = 1.22/allele, 95% CI 1.19-1.25) than in the inactive group (odds ratio = 1.30/allele, 95% CI 1.24-1.36). No such interaction was found in children and adolescents. Conclu
Published: 2011
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5. Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile

Author: Kilpeläinen, T.O. (Tuomas), Zillikens, M.C. (Carola), Stancáková, A. (Alena), Finucane, F.M. (Francis), Ried, J.S. (Janina), Langenberg, C. (Claudia), Zhang, W. (Weihua), Beckmann, J.S. (Jacques), Luan, J., Vandenput, L. (Liesbeth), Styrkarsdottir, U. (Unnur), Zhou, Y. (Yanhua), Smith, A.V. (Albert Vernon), Zhao, J.H. (Jing Hua), Amin, N. (Najaf), Vedantam, S. (Sailaja), Shin, S.-Y., Haritunians, T. (Talin), Fu, M. (Mao), Feitosa, M.F. (Mary Furlan), Kumari, M. (Meena), Halldorsson, B.V. (Bjarni), Tikkanen, E. (Emmi), Mangino, M. (Massimo), Hayward, C. (Caroline), Song, C. (Ci), Arnold, A.M. (Alice), Oostra, B.A. (Ben), Campbell, H. (Harry), Cupples, L.A. (Adrienne), Davis, K.E. (Kathryn), Döring, A. (Angela), Eiriksdottir, G. (Gudny), Estrada Gil, K. (Karol), Fernández-Real, J.M., Garcia, M. (Melissa), Gieger, C. (Christian), Glazer, N.L. (Nicole), Guiducci, C. (Candace), Hofman, A. (Albert), Humphries, S.E. (Steve), Isomaa, B. (Bo), Jacobs, L.C. (Leonie), Jula, A. (Antti), Karasik, D. (David), Karlsson, M.K. (Magnus), Khaw, K-T. (Kay-Tee), Kim, L.J. (Lauren), Kivimaki, M. (Mika), Klopp, N. (Norman), Kuhnel, B. (Brigitte), Kuusisto, J. (Johanna), Liu, Y. (YongMei), Ljunggren, Ö., Lorentzon, M. (Mattias), Luben, R.N. (Robert), McKnight, B. (Barbara), Mellström, D. (Dan), Mitchell, B.D. (Braxton), Mooser, V. (Vincent), Moreno, J.M., Männistö, S. (Satu), O'Connell, J.R. (Jeffery), Pascoe, L. (Laura), Peltonen, L. (Leena Johanna), Peral, B. (Belén), Perola, M. (Markus), Psaty, B.M. (Bruce), Salomaa, V. (Veikko), Savage, D.B. (David), Semple, R.K. (Robert), Skaric-Juric, T. (Tatjana), Sigurdsson, G. (Gunnar), Spector, T.D. (Timothy), Syvänen, A.-C., Talmud, P.J. (Philippa), Thorleifsson, G. (Gudmar), Thorsteinsdottir, U. (Unnur), Uitterlinden, A.G. (André), Tikka-Kleemola, P. (Päivi), Vidal-Puig, A. (Antonio), Wild, S.H. (Sarah), Wright, A.F. (Alan), Clegg, D.J. (Deborah), Schadt, E.E. (Eric), Wilson, J.F. (James), Rudan, I. (Igor), Ripatti, S. (Samuli), Borecki, I.B. (Ingrid), Shuldiner, A.R. (Alan), Ingelsson, E. (Erik), Jansson, J.O., Kaplan, R.C. (Robert), Gudnason, V. (Vilmundur), Harris, T.B. (Tamara), Groop, L. (Leif), Kiel, D.P. (Douglas), Rivadeneira Ramirez, F. (Fernando), Walker, M. (Mark), Barroso, I.E. (Inês), Vollenweider, P. (Peter), Waeber, G. (Gérard), Chambers, J.C. (John), Kooner, J.S. (Jaspal), Soranzo, N. (Nicole), Hirschhorn, J.N. (Joel), Stefansson, K. (Kari), Wichmann, H.E. (Heinz Erich), Ohlsson, C. (Claes), O'Rahilly, S. (Stephen), Wareham, N.J. (Nick), Speliotes, E.K. (Elizabeth), Fox, C.S. (Caroline), Laakso, M. (Markku), Loos, R.J.F. (Ruth), Aulchenko, Y.S. (Yurii), Kilpeläinen, T.O. (Tuomas), Zillikens, M.C. (Carola), Stancáková, A. (Alena), Finucane, F.M. (Francis), Ried, J.S. (Janina), Langenberg, C. (Claudia), Zhang, W. (Weihua), Beckmann, J.S. (Jacques), Luan, J., Vandenput, L. (Liesbeth), Styrkarsdottir, U. (Unnur), Zhou, Y. (Yanhua), Smith, A.V. (Albert Vernon), Zhao, J.H. (Jing Hua), Amin, N. (Najaf), Vedantam, S. (Sailaja), Shin, S.-Y., Haritunians, T. (Talin), Fu, M. (Mao), Feitosa, M.F. (Mary Furlan), Kumari, M. (Meena), Halldorsson, B.V. (Bjarni), Tikkanen, E. (Emmi), Mangino, M. (Massimo), Hayward, C. (Caroline), Song, C. (Ci), Arnold, A.M. (Alice), Oostra, B.A. (Ben), Campbell, H. (Harry), Cupples, L.A. (Adrienne), Davis, K.E. (Kathryn), Döring, A. (Angela), Eiriksdottir, G. (Gudny), Estrada Gil, K. (Karol), Fernández-Real, J.M., Garcia, M. (Melissa), Gieger, C. (Christian), Glazer, N.L. (Nicole), Guiducci, C. (Candace), Hofman, A. (Albert), Humphries, S.E. (Steve), Isomaa, B. (Bo), Jacobs, L.C. (Leonie), Jula, A. (Antti), Karasik, D. (David), Karlsson, M.K. (Magnus), Khaw, K-T. (Kay-Tee), Kim, L.J. (Lauren), Kivimaki, M. (Mika), Klopp, N. (Norman), Kuhnel, B. (Brigitte), Kuusisto, J. (Johanna), Liu, Y. (YongMei), Ljunggren, Ö., Lorentzon, M. (Mattias), Luben, R.N. (Robert), McKnight, B. (Barbara), Mellström, D. (Dan), Mitchell, B.D. (Braxton), Mooser, V. (Vincent), Moreno, J.M., Männistö, S. (Satu), O'Connell, J.R. (Jeffery), Pascoe, L. (Laura), Peltonen, L. (Leena Johanna), Peral, B. (Belén), Perola, M. (Markus), Psaty, B.M. (Bruce), Salomaa, V. (Veikko), Savage, D.B. (David), Semple, R.K. (Robert), Skaric-Juric, T. (Tatjana), Sigurdsson, G. (Gunnar), Spector, T.D. (Timothy), Syvänen, A.-C., Talmud, P.J. (Philippa), Thorleifsson, G. (Gudmar), Thorsteinsdottir, U. (Unnur), Uitterlinden, A.G. (André), Tikka-Kleemola, P. (Päivi), Vidal-Puig, A. (Antonio), Wild, S.H. (Sarah), Wright, A.F. (Alan), Clegg, D.J. (Deborah), Schadt, E.E. (Eric), Wilson, J.F. (James), Rudan, I. (Igor), Ripatti, S. (Samuli), Borecki, I.B. (Ingrid), Shuldiner, A.R. (Alan), Ingelsson, E. (Erik), Jansson, J.O., Kaplan, R.C. (Robert), Gudnason, V. (Vilmundur), Harris, T.B. (Tamara), Groop, L. (Leif), Kiel, D.P. (Douglas), Rivadeneira Ramirez, F. (Fernando), Walker, M. (Mark), Barroso, I.E. (Inês), Vollenweider, P. (Peter), Waeber, G. (Gérard), Chambers, J.C. (John), Kooner, J.S. (Jaspal), Soranzo, N. (Nicole), Hirschhorn, J.N. (Joel), Stefansson, K. (Kari), Wichmann, H.E. (Heinz Erich), Ohlsson, C. (Claes), O'Rahilly, S. (Stephen), Wareham, N.J. (Nick), Speliotes, E.K. (Elizabeth), Fox, C.S. (Caroline), Laakso, M. (Markku), Loos, R.J.F. (Ruth), and Aulchenko, Y.S. (Yurii)
Abstract: Genome-wide association studies have identified 32 loci influencing body mass index, but this measure does not distinguish lean from fat mass. To identify adiposity loci, we meta-analyzed associations between ∼2.5 million SNPs and body fat percentage from 36,626 individuals and followed up the 14 most significant (P < 10-6) independent loci in 39,576 individuals. We confirmed a previously established adiposity locus in FTO (P = 3 × 10-26) and identified two new loci associated with body fat percentage, one near IRS1 (P = 4 × 10-11) and one near SPRY2 (P = 3 × 10-8). Both loci contain genes with potential links to adipocyte physiology. Notably, the body-fat-decreasing allele near IRS1 is associated with decreased IRS1 expression and with an impaired metabolic profile, including an increased visceral to subcutaneous fat ratio, insulin resistance, dyslipidemia, risk of diabetes and coronary artery disease and decreased adiponectin levels. Our findings provide new insights into adiposity and insulin resistance.
Published: 2011
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6. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

Author: Speliotes, E.K. (Elizabeth), Willer, C.J. (Cristen), Berndt, S.I. (Sonja), Monda, K.L. (Keri), Thorleifsson, G. (Gudmar), Jackson, A.U. (Anne), Allen, H.L., Lindgren, C.M. (Cecilia), Luan, J., Mägi, R. (Reedik), Randall, J.C. (Joshua), Vedantam, S. (Sailaja), Winkler, T.W. (Thomas), Qi, L. (Lu), Workalemahu, T. (Tsegaselassie), Heid, I.M. (Iris), Steinthorsdottir, V. (Valgerdur), Stringham, H.M. (Heather), Wheeler, E. (Eleanor), Wood, A.R. (Andrew), Ferreira, T. (Teresa), Weyant, R.J. (Robert), Segrè, A.V. (Ayellet), Eestrada, K. (Karol), Liang, L. (Liming), Nemesh, J. (James), Park, J.H., Gustafsson, S. (Stefan), Kilpeläinen, T.O. (Tuomas), Yang, J. (Joanna), Bouatia-Naji, N. (Nabila), Eesko, T. (Tõnu), Feitosa, M.F. (Mary Furlan), Kutalik, Z. (Zoltán), Mangino, M. (Massimo), Raychaudhuri, S. (Soumya), Scherag, A. (Andre), Smith, A.V. (Albert Vernon), Welch, R.P. (Ryan), Zhao, J.H. (Jing Hua), Aben, K.K.H. (Katja), Absher, D. (Devin), Amin, N. (Najaf), Dixon, A.L. (Anna), Fisher, E. (Eeva), Glazer, N.L. (Nicole), Goddard, M.E. (Michael), Heard-Costa, N.L. (Nancy), Hoesel, V. (Volker), Hottenga, J.J. (Jouke Jan), Johansson, A. (Åsa), Johnson, T. (Toby), Ketkar, S. (Shamika), Lamina, C. (Claudia), Li, S. (Shengxu), Moffatt, M.F. (Miriam), Myers, R.H. (Richard), Narisu, N. (Narisu), Perry, J.R.B. (John), Peters, M.J. (Marjolein), Preuss, M. (Michael), Ripatti, S. (Samuli), Rivadeneira Ramirez, F. (Fernando), Sandholt, C. (Camilla), Scott, L.J. (Laura), Timpson, N.J. (Nicholas), Tyrer, J.P. (Jonathan), Wingerden, S. (Sophie) van, White, C.C. (Charles), Wiklund, F. (Fredrik), Barlassina, C. (Christina), Chasman, D.I. (Daniel), Cooper, M.N. (Matthew), Jansson, J.O., Lawrence, R.W. (Robert), Pellikka, N. (Niina), Prokopenko, I. (Inga), Shi, J. (Jianxin), Thiering, E. (Eelisabeth), Alavere, H. (Helene), Alibrandi, M.T.S. (Maria), Almgren, P. (Peter), Arnold, A.M. (Alice), Aspelund, T. (Thor), Atwood, L.D. (Larry), Balkau, B. (Beverley), Balmforth, A.J. (Anthony), Bennett, A.J. (Amanda), Ben-Shlomo, Y., Bergman, R.N. (Richard), Bergmann, S.M. (Sven), Biebermann, H. (Heike), Blakemore, A.I.F. (Alexandra), Boes, T. (Tanja), Bonnycastle, L.L. (Lori), Bornstein, S.R. (Stefan), Brown, M.J. (Morris), Buchanan, T.A. (Thomas), Busonero, F., Campbell, H. (Harry), Cappuccio, F.P. (Francesco), Cavalcanti-Proença, C. (Christine), Chen, Y.D.I. (Yii-Der Ida), Chen, C.-M. (Chih-Mei), Chines, P.S. (Peter), Clarke, R., Coin, L. (Lachlan), Connell, J. (John), Day, I.N.M. (Ian), Heijer, M. (Martin) den, Duan, J. (Jubao), Eebrahim, S. (Shah), Eelliott, P. (Paul), Eelosua, R. (Roberto), Eeiriksdottir, G. (Gudny), Eerdos, M.R. (Micheal), Eeriksson, J.G. (Johan), Facheris, M.F. (Maurizio), Felix, S.B. (Stephan), Fischer-Posovszky, P. (Pamela), Folsom, A.R. (Aaron), Friedrich, N. (Nele), Freimer, N.B. (Nelson), Fu, M. (Mao), Gaget, S. (Stefan), Gejman, P.V. (Pablo), Geus, E.J.C. (Eco) de, Gieger, C. (Christian), Gjesing, A.P. (Anette), Goel, A. (Anuj), Goyette, P. (Philippe), Grallert, H. (Harald), Gräßler, J. (Jürgen), Greenawalt, D. (Danielle), Groves, C.J. (Christopher), Gudnason, V. (Vilmundur), Guiducci, C. (Candace), Hartikainen, A.L., Hassanali, N. (Neelam), Hall, A.S. (Alistair), Havulinna, A.S. (Aki), Hayward, C. (Caroline), Heath, A.C. (Andrew), Hengstenberg, C. (Christian), Hicks, A.A. (Andrew), Hinney, A. (Anke), Hofman, A. (Albert), Homuth, G. (Georg), Hui, J. (Jennie), Igl, W. (Wilmar), Iribarren, C. (Carlos), Isomaa, B. (Bo), Jacobs, K.B. (Kevin), Jarick, I. (Ivonne), Jewell, E. (Eelizabeth), John, U. (Ulrich), Jørgensen, T. (Torben), Jousilahti, P. (Pekka), Jula, A. (Antti), Kaakinen, M. (Marika), Kajantie, E. (Eero), Kaplan, R.C. (Robert), Kathiresan, S. (Sekar), Kettunen, J. (Johannes), Kinnunen, L. (Leena), Knowles, J.W. (Joshua), Kolcic, I. (Ivana), König, I.R. (Inke), Koskinen, S. (Seppo), Kovacs, P. (Peter), Kusisto, J. (Johanna), Kraft, P. (Peter), Kvaløy, K. (Kirsti), Laitinen, J. (Jaana), Lantieri, O. (Olivier), Lanzani, C. (Chiara), Launer, L.J. (Lenore), Lecoeur, C. (Cécile), Lehtimäki, T. (Terho), Lettre, G. (Guillaume), Liu, J. (Jianjun), Lokki, M.L., Lorentzon, M. (Mattias), Luben, R.N. (Robert), Ludwig, B. (Barbara), Manunta, P. (Paolo), Marek, D. (Diana), Marre, M. (Michel), Martin, N.G. (Nicholas), McArdle, W.L. (Wendy), McCarthy, M.I. (Mark), McKnight, B. (Barbara), Meitinger, T. (Thomas), Melander, O. (Olle), Meyre, D. (David), Midthjell, K. (Kristian), Montgomery, G.W. (Grant), Morken, M.A. (Mario), Morris, A.D. (Andrew), Mulic, R. (Rosanda), Ngwa, J.S., Nelis, M. (Mari), Neville, M.J. (Matthew), Nyholt, D.R. (Dale), O'Ddonnell, C.J. (Christopher), O'Rahilly, S. (Stephen), Ong, K. (Ken), Oostra, B.A. (Ben), Paré, G. (Guillaume), Parker, A.N. (Alex), Perola, M. (Markus), Pichler, I. (Irene), Pietilainen, K.H. (Kirsi Hannele), Platou, C.P. (Carl), Polasek, O. (Ozren), Pouta, A. (Anneli), Rafelt, S. (Suzanne), Raitakari, O. (Olli), Rayner, N.W. (Nigel William), Ridderstråle, M. (Martin), Rief, W. (Winfried), Ruokonen, A. (Aimo), Robertson, N.R. (Neil), Rzehak, P. (Peter), Salomaa, V. (Veikko), Sanders, A.R. (Alan), Sandhu, M.S. (Manjinder), Sanna, S. (Serena), Saramies, J. (Jouko), Savolainen, M.J. (Markku), Schipf, S. (Sabine), Schreiber, S. (Stefan), Schunkert, H. (Heribert), Silander, K. (Kaisa), Sinisalo, J. (Juha), Siscovick, D.S. (David), Smit, J.H. (Jan), Soranzo, N. (Nicole), Sovio, U. (Ulla), Stephens, J. (Jonathan), Surakka, I. (Ida), Swift, A.J. (Amy), Tammesoo, M.L., Tardif, J.-C. (Jean-Claude), Teder-Laving, M. (Maris), Teslovich, T.M. (Tanya), Thompson, J.R. (John), Thomson, B. (Brian), Tönjes, A. (Anke), Tuomi, T. (Tiinamaija), Meurs, J.B.J. (Joyce) van, OMen, G.J. van, Vatin, V. (Vincent), Viikari, J. (Jorma), Visvikis-Siest, S. (Sophie), Vitart, V. (Veronique), Vogel, C.I. (Carla), Voight, B.F. (Benjamin), Waite, L. (Lindsay), Wallaschofski, H. (Henri), Walters, G.B. (Bragi), Widen, E. (Elisabeth), Wiegand, S. (Susanna), Wild, S.H. (Sarah), Willemsen, G.A.H.M. (Gonneke), Witte, D.R. (Deniel), Witteman, J.C.M. (Jacqueline), Xu, J. (Jianfeng), Zhang, Q. (Qunyuan), Zgaga, L. (Lina), Ziegler, A. (Andreas), Zitting, P. (Paavo), Beilby, J.P. (John), FarOqi, I.S. (Ssadaf), Hebebrand, J. (Johannes), Huikuri, H.V. (Heikki), James, A. (Alan), Kähönen, M. (Mika), Levinson, D.F. (Douglas), MacCiardi, F. (Fabio), Nieminen, M.S. (Markku), Ohlsson, C. (Claes), Palmer, C. (Cameron), Ridker, P.M. (Paul), Stumvoll, M. (Michael), Beckmann, J.S. (Jacques), Boeing, H. (Heiner), Boerwinkle, E.A. (Eric), Boomsma, D.I. (Dorret), Caulfield, M. (Mark), Chanock, S.J. (Stephen), Collins, F.S. (Francis), Cupples, L.A. (Adrienne), Eerdmann, J. (Jeanette), Frogue, P. (Philippe), Grönberg, H. (Henrik), Gyllensten, U. (Ulf), Hansen, T. (Torben), Harris, T.B. (Tamara), Hattersley, A.T. (Andrew), Hayes, R.B. (Richard), Heinrich, J. (Joachim), Hu, F.B. (Frank), Hveem, K. (Kristian), Illig, T. (Thomas), Järvelin, M.R., Kaprio, J. (Jaakko), Karpe, F. (Fredrik), Khaw, K-T. (Kay-Tee), Kiemeney, L.A.L.M. (Bart), Krude, H., Laakso, M. (Markku), Lawlor, D.A. (Debbie), Metspalu, A. (Andres), Munroe, P. (Patricia), Ouwehand, W.H. (Willem), Pedersen, O. (Oluf), Penninx, B.W.J.H. (Brenda), Pramstaller, P.P. (Peter Paul), Quertermous, T. (Thomas), Reinehr, T. (Thomas), Rissanen, A. (Aila), Rudan, I. (Igor), Samani, N.J. (Nilesh), Schwarz, P.E.H. (Peter), Shuldiner, A.R. (Alan), Spector, T.D. (Timothy), Tuomilehto, J. (Jaakko), Uda, M. (Manuela), Uitterlinden, A.G. (André), Valle, T.T. (Timo), Wabitsch, M. (Martin), Waeber, G. (Gérard), Wareham, N.J. (Nick), Watkins, H. (Hugh), Wilson, J.F. (James), Wright, A.F. (Alan), Zillikens, M.C. (Carola), ChatterjE, N. (Nilanjan), McCarroll, S.A. (Steve), Purcell, S. (Shaun), Schadt, E.E. (Eric), Visscher, P.M. (Peter), Assimes, T.L. (Themistocles), Borecki, I.B. (Ingrid), Deloukas, P. (Panagiotis), Fox, C.S. (Caroline), Groop, L. (Leif), Haritunians, T. (Talin), Hunter, D.J. (David), Mohlke, K.L. (Karen), O'ConneL, J.R. (Jeffrey), Peltonen, L. (Leena Johanna), SchleSinger, D. (David), Strachan, D.P. (David), Watanabe, R.M. (Richard), Duijn, C.M. (Cornelia) van, Wichmann, H.E. (Heinz Erich), Frayling, T.M. (Timothy), Thorsteinsdottir, U. (Unnur), Abecasis, G.R. (Gonçalo), Boehnke, M. (Michael), StefanSon, K. (Kari), North, K.E. (Kari), McArthy, M.I. (Mark), Hirschhorn, J.N. (Joel), IngelSon, E. (Erik), Loos, R.J.F. (Ruth), Weedon, M.N. (Michael), Speliotes, E.K. (Elizabeth), Willer, C.J. (Cristen), Berndt, S.I. (Sonja), Monda, K.L. (Keri), Thorleifsson, G. (Gudmar), Jackson, A.U. (Anne), Allen, H.L., Lindgren, C.M. (Cecilia), Luan, J., Mägi, R. (Reedik), Randall, J.C. (Joshua), Vedantam, S. (Sailaja), Winkler, T.W. (Thomas), Qi, L. (Lu), Workalemahu, T. (Tsegaselassie), Heid, I.M. (Iris), Steinthorsdottir, V. (Valgerdur), Stringham, H.M. (Heather), Wheeler, E. (Eleanor), Wood, A.R. (Andrew), Ferreira, T. (Teresa), Weyant, R.J. (Robert), Segrè, A.V. (Ayellet), Eestrada, K. (Karol), Liang, L. (Liming), Nemesh, J. (James), Park, J.H., Gustafsson, S. (Stefan), Kilpeläinen, T.O. (Tuomas), Yang, J. (Joanna), Bouatia-Naji, N. (Nabila), Eesko, T. (Tõnu), Feitosa, M.F. (Mary Furlan), Kutalik, Z. (Zoltán), Mangino, M. (Massimo), Raychaudhuri, S. (Soumya), Scherag, A. (Andre), Smith, A.V. (Albert Vernon), Welch, R.P. (Ryan), Zhao, J.H. (Jing Hua), Aben, K.K.H. (Katja), Absher, D. (Devin), Amin, N. (Najaf), Dixon, A.L. (Anna), Fisher, E. (Eeva), Glazer, N.L. (Nicole), Goddard, M.E. (Michael), Heard-Costa, N.L. (Nancy), Hoesel, V. (Volker), Hottenga, J.J. (Jouke Jan), Johansson, A. (Åsa), Johnson, T. (Toby), Ketkar, S. (Shamika), Lamina, C. (Claudia), Li, S. (Shengxu), Moffatt, M.F. (Miriam), Myers, R.H. (Richard), Narisu, N. (Narisu), Perry, J.R.B. (John), Peters, M.J. (Marjolein), Preuss, M. (Michael), Ripatti, S. (Samuli), Rivadeneira Ramirez, F. (Fernando), Sandholt, C. (Camilla), Scott, L.J. (Laura), Timpson, N.J. (Nicholas), Tyrer, J.P. (Jonathan), Wingerden, S. (Sophie) van, White, C.C. (Charles), Wiklund, F. (Fredrik), Barlassina, C. (Christina), Chasman, D.I. (Daniel), Cooper, M.N. (Matthew), Jansson, J.O., Lawrence, R.W. (Robert), Pellikka, N. (Niina), Prokopenko, I. (Inga), Shi, J. (Jianxin), Thiering, E. (Eelisabeth), Alavere, H. (Helene), Alibrandi, M.T.S. (Maria), Almgren, P. (Peter), Arnold, A.M. (Alice), Aspelund, T. (Thor), Atwood, L.D. (Larry), Balkau, B. (Beverley), Balmforth, A.J. (Anthony), Bennett, A.J. (Amanda), Ben-Shlomo, Y., Bergman, R.N. (Richard), Bergmann, S.M. (Sven), Biebermann, H. (Heike), Blakemore, A.I.F. (Alexandra), Boes, T. (Tanja), Bonnycastle, L.L. (Lori), Bornstein, S.R. (Stefan), Brown, M.J. (Morris), Buchanan, T.A. (Thomas), Busonero, F., Campbell, H. (Harry), Cappuccio, F.P. (Francesco), Cavalcanti-Proença, C. (Christine), Chen, Y.D.I. (Yii-Der Ida), Chen, C.-M. (Chih-Mei), Chines, P.S. (Peter), Clarke, R., Coin, L. (Lachlan), Connell, J. (John), Day, I.N.M. (Ian), Heijer, M. (Martin) den, Duan, J. (Jubao), Eebrahim, S. (Shah), Eelliott, P. (Paul), Eelosua, R. (Roberto), Eeiriksdottir, G. (Gudny), Eerdos, M.R. (Micheal), Eeriksson, J.G. (Johan), Facheris, M.F. (Maurizio), Felix, S.B. (Stephan), Fischer-Posovszky, P. (Pamela), Folsom, A.R. (Aaron), Friedrich, N. (Nele), Freimer, N.B. (Nelson), Fu, M. (Mao), Gaget, S. (Stefan), Gejman, P.V. (Pablo), Geus, E.J.C. (Eco) de, Gieger, C. (Christian), Gjesing, A.P. (Anette), Goel, A. (Anuj), Goyette, P. (Philippe), Grallert, H. (Harald), Gräßler, J. (Jürgen), Greenawalt, D. (Danielle), Groves, C.J. (Christopher), Gudnason, V. (Vilmundur), Guiducci, C. (Candace), Hartikainen, A.L., Hassanali, N. (Neelam), Hall, A.S. (Alistair), Havulinna, A.S. (Aki), Hayward, C. (Caroline), Heath, A.C. (Andrew), Hengstenberg, C. (Christian), Hicks, A.A. (Andrew), Hinney, A. (Anke), Hofman, A. (Albert), Homuth, G. (Georg), Hui, J. (Jennie), Igl, W. (Wilmar), Iribarren, C. (Carlos), Isomaa, B. (Bo), Jacobs, K.B. (Kevin), Jarick, I. (Ivonne), Jewell, E. (Eelizabeth), John, U. (Ulrich), Jørgensen, T. (Torben), Jousilahti, P. (Pekka), Jula, A. (Antti), Kaakinen, M. (Marika), Kajantie, E. (Eero), Kaplan, R.C. (Robert), Kathiresan, S. (Sekar), Kettunen, J. (Johannes), Kinnunen, L. (Leena), Knowles, J.W. (Joshua), Kolcic, I. (Ivana), König, I.R. (Inke), Koskinen, S. (Seppo), Kovacs, P. (Peter), Kusisto, J. (Johanna), Kraft, P. (Peter), Kvaløy, K. (Kirsti), Laitinen, J. (Jaana), Lantieri, O. (Olivier), Lanzani, C. (Chiara), Launer, L.J. (Lenore), Lecoeur, C. (Cécile), Lehtimäki, T. (Terho), Lettre, G. (Guillaume), Liu, J. (Jianjun), Lokki, M.L., Lorentzon, M. (Mattias), Luben, R.N. (Robert), Ludwig, B. (Barbara), Manunta, P. (Paolo), Marek, D. (Diana), Marre, M. (Michel), Martin, N.G. (Nicholas), McArdle, W.L. (Wendy), McCarthy, M.I. (Mark), McKnight, B. (Barbara), Meitinger, T. (Thomas), Melander, O. (Olle), Meyre, D. (David), Midthjell, K. (Kristian), Montgomery, G.W. (Grant), Morken, M.A. (Mario), Morris, A.D. (Andrew), Mulic, R. (Rosanda), Ngwa, J.S., Nelis, M. (Mari), Neville, M.J. (Matthew), Nyholt, D.R. (Dale), O'Ddonnell, C.J. (Christopher), O'Rahilly, S. (Stephen), Ong, K. (Ken), Oostra, B.A. (Ben), Paré, G. (Guillaume), Parker, A.N. (Alex), Perola, M. (Markus), Pichler, I. (Irene), Pietilainen, K.H. (Kirsi Hannele), Platou, C.P. (Carl), Polasek, O. (Ozren), Pouta, A. (Anneli), Rafelt, S. (Suzanne), Raitakari, O. (Olli), Rayner, N.W. (Nigel William), Ridderstråle, M. (Martin), Rief, W. (Winfried), Ruokonen, A. (Aimo), Robertson, N.R. (Neil), Rzehak, P. (Peter), Salomaa, V. (Veikko), Sanders, A.R. (Alan), Sandhu, M.S. (Manjinder), Sanna, S. (Serena), Saramies, J. (Jouko), Savolainen, M.J. (Markku), Schipf, S. (Sabine), Schreiber, S. (Stefan), Schunkert, H. (Heribert), Silander, K. (Kaisa), Sinisalo, J. (Juha), Siscovick, D.S. (David), Smit, J.H. (Jan), Soranzo, N. (Nicole), Sovio, U. (Ulla), Stephens, J. (Jonathan), Surakka, I. (Ida), Swift, A.J. (Amy), Tammesoo, M.L., Tardif, J.-C. (Jean-Claude), Teder-Laving, M. (Maris), Teslovich, T.M. (Tanya), Thompson, J.R. (John), Thomson, B. (Brian), Tönjes, A. (Anke), Tuomi, T. (Tiinamaija), Meurs, J.B.J. (Joyce) van, OMen, G.J. van, Vatin, V. (Vincent), Viikari, J. (Jorma), Visvikis-Siest, S. (Sophie), Vitart, V. (Veronique), Vogel, C.I. (Carla), Voight, B.F. (Benjamin), Waite, L. (Lindsay), Wallaschofski, H. (Henri), Walters, G.B. (Bragi), Widen, E. (Elisabeth), Wiegand, S. (Susanna), Wild, S.H. (Sarah), Willemsen, G.A.H.M. (Gonneke), Witte, D.R. (Deniel), Witteman, J.C.M. (Jacqueline), Xu, J. (Jianfeng), Zhang, Q. (Qunyuan), Zgaga, L. (Lina), Ziegler, A. (Andreas), Zitting, P. (Paavo), Beilby, J.P. (John), FarOqi, I.S. (Ssadaf), Hebebrand, J. (Johannes), Huikuri, H.V. (Heikki), James, A. (Alan), Kähönen, M. (Mika), Levinson, D.F. (Douglas), MacCiardi, F. (Fabio), Nieminen, M.S. (Markku), Ohlsson, C. (Claes), Palmer, C. (Cameron), Ridker, P.M. (Paul), Stumvoll, M. (Michael), Beckmann, J.S. (Jacques), Boeing, H. (Heiner), Boerwinkle, E.A. (Eric), Boomsma, D.I. (Dorret), Caulfield, M. (Mark), Chanock, S.J. (Stephen), Collins, F.S. (Francis), Cupples, L.A. (Adrienne), Eerdmann, J. (Jeanette), Frogue, P. (Philippe), Grönberg, H. (Henrik), Gyllensten, U. (Ulf), Hansen, T. (Torben), Harris, T.B. (Tamara), Hattersley, A.T. (Andrew), Hayes, R.B. (Richard), Heinrich, J. (Joachim), Hu, F.B. (Frank), Hveem, K. (Kristian), Illig, T. (Thomas), Järvelin, M.R., Kaprio, J. (Jaakko), Karpe, F. (Fredrik), Khaw, K-T. (Kay-Tee), Kiemeney, L.A.L.M. (Bart), Krude, H., Laakso, M. (Markku), Lawlor, D.A. (Debbie), Metspalu, A. (Andres), Munroe, P. (Patricia), Ouwehand, W.H. (Willem), Pedersen, O. (Oluf), Penninx, B.W.J.H. (Brenda), Pramstaller, P.P. (Peter Paul), Quertermous, T. (Thomas), Reinehr, T. (Thomas), Rissanen, A. (Aila), Rudan, I. (Igor), Samani, N.J. (Nilesh), Schwarz, P.E.H. (Peter), Shuldiner, A.R. (Alan), Spector, T.D. (Timothy), Tuomilehto, J. (Jaakko), Uda, M. (Manuela), Uitterlinden, A.G. (André), Valle, T.T. (Timo), Wabitsch, M. (Martin), Waeber, G. (Gérard), Wareham, N.J. (Nick), Watkins, H. (Hugh), Wilson, J.F. (James), Wright, A.F. (Alan), Zillikens, M.C. (Carola), ChatterjE, N. (Nilanjan), McCarroll, S.A. (Steve), Purcell, S. (Shaun), Schadt, E.E. (Eric), Visscher, P.M. (Peter), Assimes, T.L. (Themistocles), Borecki, I.B. (Ingrid), Deloukas, P. (Panagiotis), Fox, C.S. (Caroline), Groop, L. (Leif), Haritunians, T. (Talin), Hunter, D.J. (David), Mohlke, K.L. (Karen), O'ConneL, J.R. (Jeffrey), Peltonen, L. (Leena Johanna), SchleSinger, D. (David), Strachan, D.P. (David), Watanabe, R.M. (Richard), Duijn, C.M. (Cornelia) van, Wichmann, H.E. (Heinz Erich), Frayling, T.M. (Timothy), Thorsteinsdottir, U. (Unnur), Abecasis, G.R. (Gonçalo), Boehnke, M. (Michael), StefanSon, K. (Kari), North, K.E. (Kari), McArthy, M.I. (Mark), Hirschhorn, J.N. (Joel), IngelSon, E. (Erik), Loos, R.J.F. (Ruth), and Weedon, M.N. (Michael)
Abstract: Obesity is globaLy prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined aSociations betwEn body maS index and ĝ̂1/42.8 miLion SNPs in up to 123,865 individuals with targeted foLow up of 42 SNPs in up to 125,931 aDitional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci aSociated with body maS index (P < 5-10-8), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly aSociated loci may provide new insights into human body weight regulation.
Published: 2010
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7. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

Author: Heid, I.M. (Iris), Jackson, A.U. (Anne), Randall, J.C. (Joshua), Winkler, T.W. (Thomas), Qi, L. (Lu), Ssteinthorsdottir, V. (Valgerdur), Tthorleifsson, G. (Ggudmar), Zillikens, M.C. (Carola), Sspeliotes, E.K. (Eelizabeth), Mägi, R. (Reedik), Workalemahu, T. (Tsegaselassie), White, C.C. (Charles), Bouatia-Naji, N. (Nabila), Harris, T.B. (Tamara), Berndt, S.I. (Sonja), Ingelsson, E. (Erik), Willer, C.J. (Cristen), Luan, J., Vedantam, S. (Sailaja), Eesko, T. (Tõnu), Kilpeläinen, T.O. (Tuomas), Kutalik, Z. (Zoltán), Li, S. (Shengxu), Monda, K.L. (Keri), Dixon, A.L. (Anna), Holmes, C. (Christopher), Kaplan, R.C. (Robert), Liang, L. (Liming), Min, J. (Josine), Moffatt, M.F. (Miriam), Molony, C. (Cliona), Nicholson, G. (Ggeorge), Sschadt, E.E. (Eeric), Zondervan, K.T. (Krina), Feitosa, M.F. (Mary Furlan), Ferreira, T. (Teresa), Allen, H.L., Weyant, R.J. (Robert), Wheeler, E. (Eleanor), Wood, A.R. (Andrew), Eestrada, K. (Karol), Goddard, M.E. (Michael), Lettre, G. (Guillaume), Mangino, M. (Massimo), Nyholt, D.R. (Dale), Purcell, S. (Shaun), Ssmith, A.V., Visscher, P.M. (Peter), Yang, J. (Joanna), McCcarroll, S.A. (Ssteven), Nemesh, J. (James), Voight, B.F. (Benjamin), Absher, D. (Devin), Amin, N. (Najaf), Aspelund, T. (Thor), Coin, L. (Lachlan), Glazer, N.L. (Nicole), Hayward, C. (Caroline), Heard-Ccosta, N. (Nancy), Hottenga, J.J. (Jouke Jan), Johansson, A. (Åsa), Johnson, T. (Toby), Kaakinen, M. (Marika), Kapur, K. (Karen), Ketkar, S. (Shamika), Knowles, J.W. (Joshua), Kraft, P. (Peter), Kraja, A. (Aldi), Lamina, C. (Claudia), Leitzmann, M.F. (Michael), McKknight, B. (Barbara), Morris, A.D. (Andrew), Oong, K. (Ken), Perry, J.R.B. (John), Peters, M.J. (Marjolein), Polasek, O. (Ozren), Prokopenko, I. (Inga), Rayner, N.W. (Nigel William), Ripatti, S. (Samuli), Rivadeneira Ramirez, F. (Fernando), Robertson, N.R. (Neil), Sanna, S. (Serena), Sovio, U. (Ulla), Surakka, I. (Ida), Teumer, A. (Alexander), Wingerden, S. (Sophie) van, Vitart, V. (Veronique), Zhao, J.H. (Jing Hua), Cavalcanti-Proença, C. (Christine), Chines, P.S. (Peter), Fisher, E. (Eeva), Kulzer, J.R. (Jennifer), Lecoeur, C. (Cécile), Narisu, N. (Narisu), Sandholt, C. (Camilla), Scott, L.J. (Laura), Silander, K. (Kaisa), Stark, K. (Klaus), Tammesoo, M.L., Teslovich, T.M. (Tanya), Timpson, N.J. (Nicholas), Welch, R.P. (Ryan), Chasman, D.I. (Daniel), Cooper, M.N. (Matthew), Jansson, J.O., Kettunen, J. (Johannes), Wlawrence, R. (Robert), Pellikka, N. (Niina), Perola, M. (Markus), Vandenput, L. (Liesbeth), Alavere, H. (Helene), Almgren, P. (Peter), Atwood, L.D. (Larry), Bennett, A.J. (Amanda), Biffar, R. (Reiner), Bonnycastle, L.L. (Lori), Bornstein, S.R. (Stefan), Buchanan, T.A. (Thomas), Campbell, H. (Harry), Day, I.N.M. (Ian), Dei, M. (Mariano), Dörr, M. (Marcus), Eelliott, P. (Paul), Eerdos, M.R. (Micheal), Eeriksson, J.G. (Johan), Freimer, N.B. (Nelson), Fu, M. (Mao), Gaget, S. (Stefan), Geus, E.J.C. (Eco) de, Gjesing, A.P. (Anette), Grallert, H. (Harald), Gräßler, J. (Jürgen), Groves, C.J. (Christopher), Guiducci, C. (Candace), Hartikainen, A.L., Hassanali, N. (Neelam), Havulinna, A.S. (Aki), Herzig, K.H., Hicks, A.A. (Andrew), Hui, J. (Jennie), Igl, W. (Wilmar), Jousilahti, P. (Pekka), Jula, A. (Antti), Kajantie, E. (Eero), Kinnunen, L. (Leena), Kolcic, I. (Ivana), Koskinen, S. (Seppo), Kovacs, P. (Peter), Kroemer, H.K. (Heyo), Krzelj, V. (Vjekoslav), Kuusisto, J. (Johanna), Kvaløy, K. (Kirsti), Laitinen, J. (Jaana), Lantieri, O. (Olivier), Lathrop, G.M. (Mark), Lokki, M.L., Luben, R.N. (Robert), Ludwig, B. (Barbara), McArdle, W.L. (Wendy), McCcarthy, A. (Anne), Morken, M.A. (Mario), Nelis, M. (Mari), Neville, M.J. (Matthew), Paré, G. (Guillaume), Parker, A.N. (Alex), Peden, J. (John), Pichler, I. (Irene), Pietilainen, K.H. (Kirsi Hannele), Platou, C.P. (Carl), Pouta, A. (Anneli), Ridderstråle, M. (Martin), Samani, N.J. (Nilesh), Saramies, J. (Jouko), Sinisalo, J. (Juha), Smit, J.H. (Jan), Strawbridge, R.J. (Rona), Stringham, H.M. (Heather), Swift, A.J. (Amy), Teder-Llaving, M. (Maris), Thomson, B. (Brian), Usala, G., Meurs, J.B.J. (Joyce) van, Ommen, G.J. (Gert) van, Vatin, V. (Vincent), Volpato, C.B., Wallaschofski, H. (Henri), Walters, G.B. (Bragi), Widen, E. (Elisabeth), Wild, S.H. (Sarah), Willemsen, G.A.H.M. (Gonneke), Witte, D.R. (Deniel), Zgaga, L. (Lina), Zitting, P. (Paavo), Beilby, J.P. (John), James, A. (Alan), Kähönen, M. (Mika), Lehtimäki, T. (Terho), Nieminen, M.S. (Markku), Ohlsson, C. (Claes), Palmer, C. (Cameron), Raitakari, O. (Olli), Ridker, P.M. (Paul), Stumvoll, M. (Michael), Tönjes, A. (Anke), Viikari, J. (Jorma), Balkau, B. (Beverley), Ben-Shlomo, Y., Bergman, R.N. (Richard), Boeing, H. (Heiner), Smith, A.V. (Albert Vernon), Eebrahim, S. (Shah), Froguel, P. (Philippe), Hansen, T. (Torben), Hengstenberg, C. (Christian), Hveem, K. (Kristian), Isomaa, B. (Bo), Jørgensen, T. (Torben), Karpe, F. (Fredrik), Khaw, K-T. (Kay-Tee), Laakso, M. (Markku), Lawlor, D.A. (Debbie), Marre, M. (Michel), Meitinger, T. (Thomas), Metspalu, A. (Andres), Midthjell, K. (Kristian), Pedersen, O. (Oluf), Salomaa, V. (Veikko), Schwarz, P.E.H. (Peter), Tuomi, T. (Tiinamaija), Tuomilehto, J. (Jaakko), Valle, T.T. (Timo), Wareham, N.J. (Nick), Arnold, A.M. (Alice), Beckmann, J.S. (Jacques), Bergmann, S.M. (Sven), Boerwinkle, E.A. (Eric), Boomsma, D.I. (Dorret), Caulfield, M. (Mark), Collins, F.S. (Francis), Eeiriksdottir, G. (Gudny), Gudnason, V. (Vilmundur), Gyllensten, U. (Ulf), Hamsten, A. (Anders), Hattersley, A.T. (Andrew), Hofman, A. (Albert), Hu, F.B. (Frank), Illig, T. (Thomas), Iribarren, C. (Carlos), Järvelin, M.R., Kao, W.H.L. (Wen), Kaprio, J. (Jaakko), Launer, L.J. (Lenore), Munroe, P. (Patricia), Oostra, B.A. (Ben), Penninx, B.W.J.H. (Brenda), Pramstaller, P.P. (Peter Paul), Psaty, B.M. (Bruce), Quertermous, T. (Thomas), Rissanen, A. (Aila), Rudan, I. (Igor), Shuldiner, A.R. (Alan), Soranzo, N. (Nicole), Spector, T.D. (Timothy), Syvanen, A.C., Uda, M. (Manuela), Uitterlinden, A.G. (André), Völzke, H. (Henry), Vollenweider, P. (Peter), Wilson, J.F. (James), Witteman, J.C.M. (Jacqueline), Wright, A.F. (Alan), Abecasis, G.R. (Gonçalo), Boehnke, M. (Michael), Borecki, I.B. (Ingrid), Deloukas, P. (Panagiotis), Frayling, T.M. (Timothy), Groop, L. (Leif), Haritunians, T. (Talin), Hunter, D.J. (David), North, K.E. (Kari), O'Cconnell, J.R. (Jeffrey), Peltonen, L. (Leena Johanna), Schlessinger, D., Strachan, D.P. (David), Hirschhorn, J.N. (Joel), Assimes, T.L. (Themistocles), Wichmann, H.E. (Heinz Erich), Thorsteinsdottir, U. (Unnur), Duijn, C.M. (Cornelia) van, Stefansson, K. (Kari), Cupples, L.A. (Adrienne), Loos, R.J.F. (Ruth), Barroso, I.E. (Inês), Fox, C.S. (Caroline), Mohlke, K.L. (Karen), Lindgren, C.M. (Cecilia), Watanabe, R.M. (Richard), Weedon, M.N. (Michael), Heid, I.M. (Iris), Jackson, A.U. (Anne), Randall, J.C. (Joshua), Winkler, T.W. (Thomas), Qi, L. (Lu), Ssteinthorsdottir, V. (Valgerdur), Tthorleifsson, G. (Ggudmar), Zillikens, M.C. (Carola), Sspeliotes, E.K. (Eelizabeth), Mägi, R. (Reedik), Workalemahu, T. (Tsegaselassie), White, C.C. (Charles), Bouatia-Naji, N. (Nabila), Harris, T.B. (Tamara), Berndt, S.I. (Sonja), Ingelsson, E. (Erik), Willer, C.J. (Cristen), Luan, J., Vedantam, S. (Sailaja), Eesko, T. (Tõnu), Kilpeläinen, T.O. (Tuomas), Kutalik, Z. (Zoltán), Li, S. (Shengxu), Monda, K.L. (Keri), Dixon, A.L. (Anna), Holmes, C. (Christopher), Kaplan, R.C. (Robert), Liang, L. (Liming), Min, J. (Josine), Moffatt, M.F. (Miriam), Molony, C. (Cliona), Nicholson, G. (Ggeorge), Sschadt, E.E. (Eeric), Zondervan, K.T. (Krina), Feitosa, M.F. (Mary Furlan), Ferreira, T. (Teresa), Allen, H.L., Weyant, R.J. (Robert), Wheeler, E. (Eleanor), Wood, A.R. (Andrew), Eestrada, K. (Karol), Goddard, M.E. (Michael), Lettre, G. (Guillaume), Mangino, M. (Massimo), Nyholt, D.R. (Dale), Purcell, S. (Shaun), Ssmith, A.V., Visscher, P.M. (Peter), Yang, J. (Joanna), McCcarroll, S.A. (Ssteven), Nemesh, J. (James), Voight, B.F. (Benjamin), Absher, D. (Devin), Amin, N. (Najaf), Aspelund, T. (Thor), Coin, L. (Lachlan), Glazer, N.L. (Nicole), Hayward, C. (Caroline), Heard-Ccosta, N. (Nancy), Hottenga, J.J. (Jouke Jan), Johansson, A. (Åsa), Johnson, T. (Toby), Kaakinen, M. (Marika), Kapur, K. (Karen), Ketkar, S. (Shamika), Knowles, J.W. (Joshua), Kraft, P. (Peter), Kraja, A. (Aldi), Lamina, C. (Claudia), Leitzmann, M.F. (Michael), McKknight, B. (Barbara), Morris, A.D. (Andrew), Oong, K. (Ken), Perry, J.R.B. (John), Peters, M.J. (Marjolein), Polasek, O. (Ozren), Prokopenko, I. (Inga), Rayner, N.W. (Nigel William), Ripatti, S. (Samuli), Rivadeneira Ramirez, F. (Fernando), Robertson, N.R. (Neil), Sanna, S. (Serena), Sovio, U. (Ulla), Surakka, I. (Ida), Teumer, A. (Alexander), Wingerden, S. (Sophie) van, Vitart, V. (Veronique), Zhao, J.H. (Jing Hua), Cavalcanti-Proença, C. (Christine), Chines, P.S. (Peter), Fisher, E. (Eeva), Kulzer, J.R. (Jennifer), Lecoeur, C. (Cécile), Narisu, N. (Narisu), Sandholt, C. (Camilla), Scott, L.J. (Laura), Silander, K. (Kaisa), Stark, K. (Klaus), Tammesoo, M.L., Teslovich, T.M. (Tanya), Timpson, N.J. (Nicholas), Welch, R.P. (Ryan), Chasman, D.I. (Daniel), Cooper, M.N. (Matthew), Jansson, J.O., Kettunen, J. (Johannes), Wlawrence, R. (Robert), Pellikka, N. (Niina), Perola, M. (Markus), Vandenput, L. (Liesbeth), Alavere, H. (Helene), Almgren, P. (Peter), Atwood, L.D. (Larry), Bennett, A.J. (Amanda), Biffar, R. (Reiner), Bonnycastle, L.L. (Lori), Bornstein, S.R. (Stefan), Buchanan, T.A. (Thomas), Campbell, H. (Harry), Day, I.N.M. (Ian), Dei, M. (Mariano), Dörr, M. (Marcus), Eelliott, P. (Paul), Eerdos, M.R. (Micheal), Eeriksson, J.G. (Johan), Freimer, N.B. (Nelson), Fu, M. (Mao), Gaget, S. (Stefan), Geus, E.J.C. (Eco) de, Gjesing, A.P. (Anette), Grallert, H. (Harald), Gräßler, J. (Jürgen), Groves, C.J. (Christopher), Guiducci, C. (Candace), Hartikainen, A.L., Hassanali, N. (Neelam), Havulinna, A.S. (Aki), Herzig, K.H., Hicks, A.A. (Andrew), Hui, J. (Jennie), Igl, W. (Wilmar), Jousilahti, P. (Pekka), Jula, A. (Antti), Kajantie, E. (Eero), Kinnunen, L. (Leena), Kolcic, I. (Ivana), Koskinen, S. (Seppo), Kovacs, P. (Peter), Kroemer, H.K. (Heyo), Krzelj, V. (Vjekoslav), Kuusisto, J. (Johanna), Kvaløy, K. (Kirsti), Laitinen, J. (Jaana), Lantieri, O. (Olivier), Lathrop, G.M. (Mark), Lokki, M.L., Luben, R.N. (Robert), Ludwig, B. (Barbara), McArdle, W.L. (Wendy), McCcarthy, A. (Anne), Morken, M.A. (Mario), Nelis, M. (Mari), Neville, M.J. (Matthew), Paré, G. (Guillaume), Parker, A.N. (Alex), Peden, J. (John), Pichler, I. (Irene), Pietilainen, K.H. (Kirsi Hannele), Platou, C.P. (Carl), Pouta, A. (Anneli), Ridderstråle, M. (Martin), Samani, N.J. (Nilesh), Saramies, J. (Jouko), Sinisalo, J. (Juha), Smit, J.H. (Jan), Strawbridge, R.J. (Rona), Stringham, H.M. (Heather), Swift, A.J. (Amy), Teder-Llaving, M. (Maris), Thomson, B. (Brian), Usala, G., Meurs, J.B.J. (Joyce) van, Ommen, G.J. (Gert) van, Vatin, V. (Vincent), Volpato, C.B., Wallaschofski, H. (Henri), Walters, G.B. (Bragi), Widen, E. (Elisabeth), Wild, S.H. (Sarah), Willemsen, G.A.H.M. (Gonneke), Witte, D.R. (Deniel), Zgaga, L. (Lina), Zitting, P. (Paavo), Beilby, J.P. (John), James, A. (Alan), Kähönen, M. (Mika), Lehtimäki, T. (Terho), Nieminen, M.S. (Markku), Ohlsson, C. (Claes), Palmer, C. (Cameron), Raitakari, O. (Olli), Ridker, P.M. (Paul), Stumvoll, M. (Michael), Tönjes, A. (Anke), Viikari, J. (Jorma), Balkau, B. (Beverley), Ben-Shlomo, Y., Bergman, R.N. (Richard), Boeing, H. (Heiner), Smith, A.V. (Albert Vernon), Eebrahim, S. (Shah), Froguel, P. (Philippe), Hansen, T. (Torben), Hengstenberg, C. (Christian), Hveem, K. (Kristian), Isomaa, B. (Bo), Jørgensen, T. (Torben), Karpe, F. (Fredrik), Khaw, K-T. (Kay-Tee), Laakso, M. (Markku), Lawlor, D.A. (Debbie), Marre, M. (Michel), Meitinger, T. (Thomas), Metspalu, A. (Andres), Midthjell, K. (Kristian), Pedersen, O. (Oluf), Salomaa, V. (Veikko), Schwarz, P.E.H. (Peter), Tuomi, T. (Tiinamaija), Tuomilehto, J. (Jaakko), Valle, T.T. (Timo), Wareham, N.J. (Nick), Arnold, A.M. (Alice), Beckmann, J.S. (Jacques), Bergmann, S.M. (Sven), Boerwinkle, E.A. (Eric), Boomsma, D.I. (Dorret), Caulfield, M. (Mark), Collins, F.S. (Francis), Eeiriksdottir, G. (Gudny), Gudnason, V. (Vilmundur), Gyllensten, U. (Ulf), Hamsten, A. (Anders), Hattersley, A.T. (Andrew), Hofman, A. (Albert), Hu, F.B. (Frank), Illig, T. (Thomas), Iribarren, C. (Carlos), Järvelin, M.R., Kao, W.H.L. (Wen), Kaprio, J. (Jaakko), Launer, L.J. (Lenore), Munroe, P. (Patricia), Oostra, B.A. (Ben), Penninx, B.W.J.H. (Brenda), Pramstaller, P.P. (Peter Paul), Psaty, B.M. (Bruce), Quertermous, T. (Thomas), Rissanen, A. (Aila), Rudan, I. (Igor), Shuldiner, A.R. (Alan), Soranzo, N. (Nicole), Spector, T.D. (Timothy), Syvanen, A.C., Uda, M. (Manuela), Uitterlinden, A.G. (André), Völzke, H. (Henry), Vollenweider, P. (Peter), Wilson, J.F. (James), Witteman, J.C.M. (Jacqueline), Wright, A.F. (Alan), Abecasis, G.R. (Gonçalo), Boehnke, M. (Michael), Borecki, I.B. (Ingrid), Deloukas, P. (Panagiotis), Frayling, T.M. (Timothy), Groop, L. (Leif), Haritunians, T. (Talin), Hunter, D.J. (David), North, K.E. (Kari), O'Cconnell, J.R. (Jeffrey), Peltonen, L. (Leena Johanna), Schlessinger, D., Strachan, D.P. (David), Hirschhorn, J.N. (Joel), Assimes, T.L. (Themistocles), Wichmann, H.E. (Heinz Erich), Thorsteinsdottir, U. (Unnur), Duijn, C.M. (Cornelia) van, Stefansson, K. (Kari), Cupples, L.A. (Adrienne), Loos, R.J.F. (Ruth), Barroso, I.E. (Inês), Fox, C.S. (Caroline), Mohlke, K.L. (Karen), Lindgren, C.M. (Cecilia), Watanabe, R.M. (Richard), and Weedon, M.N. (Michael)
Abstract: Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified. We conducted a meta-analysis of 32 genome-wide association studies for WHR adjusted for body mass index (comprising up to 77,167 participants), following up 16 loci in an additional 29 studies (comprising up to 113,636 subjects). We identified 13 new loci in or near RSPO3, VEGFA, TBX15-WARS2, NFE2L3, GRB14, DNM3-PIGC, ITPR2-SPN, LY86, HOXC13, ADAMTS9, ZNRF3-KREMEN1, NISCH-STAB1 and CPEB4 (P = 1.9-10-9 to P = 1.8-10-40) and the known signal at LYPLAL1. Seven of these loci exhibited marked sexual dimorphism, all with a stronger effect on WHR in women than men (P for sex difference = 1.9-10-3 to P = 1.2-10-13). These findings provide evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions.
Published: 2010
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8. NRXN3Is a novel locus for waist circumference: A genome-wide association study from the CHARGE consortium

Author: Heard-Costa, N.L. (Nancy), Zillikens, M.C. (Carola), Monda, K.L. (Keri), Johansson, A. (Åsa), Harris, T.B. (Tamara), Fu, M. (Mao), Haritunians, T. (Talin), Feitosa, M.F. (Mary Furlan), Aspelund, T. (Thor), Eiriksdottir, G. (Gudny), Garcia, M. (Melissa), Launer, L.J. (Lenore), Smith, A.V. (Albert Vernon), Mitchell, B.D. (Braxton), McArdle, P.F. (Patrick), Shuldiner, A.R. (Alan), Bielinski, S.J. (Suzette), Boerwinkle, E.A. (Eric), Brancati, F. (Fred), Demerath, E.W. (Ellen), Pankow, J.S. (James), Arnold, A.M. (Alice), Chen, Y.D.I. (Yii-Der Ida), Glazer, N.L. (Nicole), McKnight, B. (Barbara), Psaty, B.M. (Bruce), Rotter, J.I. (Jerome), Amin, N. (Najaf), Campbell, H. (Harry), Gyllensten, U. (Ulf), Pattaro, C. (Cristian), Pramstaller, P.P. (Peter Paul), Rudan, I. (Igor), Struchalin, M.V. (Maksim), Vitart, V. (Veronique), Gao, X. (Xiaoyi), Kraja, A. (Aldi), Province, M.A. (Mike), Zhang, Q. (Qunyuan), Atwood, L.D. (Larry), Dupuis, J. (Josée), Hirschhorn, J.N. (Joel), Jaquish, C.E. (Cashell), Vasan, R.S. (Ramachandran Srini), White, C.C. (Charles), Aulchenko, Y.S. (Yurii), Estrada Gil, K. (Karol), Hofman, A. (Albert), Rivadeneira Ramirez, F. (Fernando), Uitterlinden, A.G. (André), Witteman, J.C.M. (Jacqueline), Oostra, B.A. (Ben), Kaplan, R.C. (Robert), Gudnason, V. (Vilmundur), O'Donnell, C.J. (Christopher), O´Connell, J.R., Borecki, I.B. (Ingrid), Duijn, C.M. (Cornelia) van, Cupples, L.A. (Adrienne), Fox, C.S. (Caroline), North, K.E. (Kari), Heard-Costa, N.L. (Nancy), Zillikens, M.C. (Carola), Monda, K.L. (Keri), Johansson, A. (Åsa), Harris, T.B. (Tamara), Fu, M. (Mao), Haritunians, T. (Talin), Feitosa, M.F. (Mary Furlan), Aspelund, T. (Thor), Eiriksdottir, G. (Gudny), Garcia, M. (Melissa), Launer, L.J. (Lenore), Smith, A.V. (Albert Vernon), Mitchell, B.D. (Braxton), McArdle, P.F. (Patrick), Shuldiner, A.R. (Alan), Bielinski, S.J. (Suzette), Boerwinkle, E.A. (Eric), Brancati, F. (Fred), Demerath, E.W. (Ellen), Pankow, J.S. (James), Arnold, A.M. (Alice), Chen, Y.D.I. (Yii-Der Ida), Glazer, N.L. (Nicole), McKnight, B. (Barbara), Psaty, B.M. (Bruce), Rotter, J.I. (Jerome), Amin, N. (Najaf), Campbell, H. (Harry), Gyllensten, U. (Ulf), Pattaro, C. (Cristian), Pramstaller, P.P. (Peter Paul), Rudan, I. (Igor), Struchalin, M.V. (Maksim), Vitart, V. (Veronique), Gao, X. (Xiaoyi), Kraja, A. (Aldi), Province, M.A. (Mike), Zhang, Q. (Qunyuan), Atwood, L.D. (Larry), Dupuis, J. (Josée), Hirschhorn, J.N. (Joel), Jaquish, C.E. (Cashell), Vasan, R.S. (Ramachandran Srini), White, C.C. (Charles), Aulchenko, Y.S. (Yurii), Estrada Gil, K. (Karol), Hofman, A. (Albert), Rivadeneira Ramirez, F. (Fernando), Uitterlinden, A.G. (André), Witteman, J.C.M. (Jacqueline), Oostra, B.A. (Ben), Kaplan, R.C. (Robert), Gudnason, V. (Vilmundur), O'Donnell, C.J. (Christopher), O´Connell, J.R., Borecki, I.B. (Ingrid), Duijn, C.M. (Cornelia) van, Cupples, L.A. (Adrienne), Fox, C.S. (Caroline), and North, K.E. (Kari)
Abstract: Central abdominal fat is a strong risk factor for diabetes and cardiovascular disease. To identify common variants influencing central abdominal fat, we conducted a two-stage genome-wide association analysis for waist circumference (WC). In total, three loci reached genome-wide significance. In stage 1, 31,373 individuals of Caucasian descent from eight cohort studies confirmed the role of FTO and MC4R and identified one novel loc
Published: 2009
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8 results on '"Fu, M. (Mao)"'

1. Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices

2. Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults

3. Genome-wide physical activity interactions in adiposity:a meta-analysis of 200,452 adults

4. Physical activity attenuates the influence of FTO variants on obesity risk: A meta-analysis of 218,166 adults and 19,268 children

5. Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile

6. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

7. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

8. NRXN3Is a novel locus for waist circumference: A genome-wide association study from the CHARGE consortium

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