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18 results on '"Fu, Keyi"'

8. Phage P2-71 against multi-drug resistant Proteus mirabilis: isolation, characterization, and non-antibiotic antimicrobial potential

Author

Dong, Zhiyou, primary, Wu, Ruihu, additional, Liu, Lijuan, additional, Ai, Shengquan, additional, Yang, Jinpeng, additional, Li, Qianlan, additional, Fu, Keyi, additional, Zhou, Yunian, additional, Fu, Hualin, additional, Zhou, Ziyao, additional, Liu, Haifeng, additional, Zhong, Zhijun, additional, Qiu, Xianmeng, additional, and Peng, Guangneng, additional

Published
2024
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11. Distribution and association of antimicrobial resistance and virulence characteristics in Enterococcus spp. isolates from captive Asian elephants in China

Author

Yang, Jinpeng, primary, Chen, Yanshan, additional, Dong, Zhiyou, additional, Zhang, Wenqing, additional, Liu, Lijuan, additional, Meng, Wanyu, additional, Li, Qianlan, additional, Fu, Keyi, additional, Zhou, Ziyao, additional, Liu, Haifeng, additional, Zhong, Zhijun, additional, Xiao, Xiao, additional, Zhu, Jieyao, additional, and Peng, Guangneng, additional

Published
2023
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13. Altitude‐dependent metabolite biomarkers reveal the mechanism of plateau pika adaptation to high altitudes.

Author

CHEN, Xi, WANG, Zaiwei, SU, Junhu, LI, Huan, XIONG, Jinbo, FU, Keyi, WANG, Zilong, YUAN, Xuefeng, SHI, Ziyue, MIAO, Xiumei, YANG, Mei, YANG, Yunfeng, and SHI, Zunji

Subjects
PHYSIOLOGY, ALTITUDES, MACHINE learning, BIOMARKERS, EFFECT of stress on animals, PLATEAUS
Abstract

The harsh environment in the Tibetan plateau, the highest place in the world, poses thermoregulatory challenges and hypoxic stress to animals. The impacts of plateau environment on animal physiology and reproduction include external factors such as strong ultraviolet radiation and low temperature, and internal factors such as animal metabolites and gut microbiota. However, it remains unclear how plateau pika adapt to high altitudes through the combination of serum metabolites and gut microbiota. To this end, we captured 24 wild plateau pikas at the altitudes of 3400, 3600, or 3800 m a.s.l. in a Tibetan alpine grassland. Using the machine learning algorithms (random forest), we identified five biomarkers of serum metabolites indicative of the altitudes, that is, dihydrotestosterone, homo‐l‐arginine, alpha‐ketoglutaric‐acid, serotonin, and threonine, which were related to body weight, reproduction, and energy metabolism of pika. Those metabolic biomarkers were positively correlated with Lachnospiraceae_ Agathobacter, Ruminococcaceae, or Prevotellaceae_Prevotella, suggesting the close relationship between metabolites and gut microbiota. By identifying the metabolic biomarkers and gut microbiota analysis, we reveal the mechanisms of adaptation to high altitudes in plateau pika. [ABSTRACT FROM AUTHOR]

Published
2023
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17. Oral immunocontraceptive vaccines: A novel approach for fertility control in wildlife.

Author

Yang, Jinpeng, Zhou, Ziyao, Li, Gangshi, Dong, Zhiyou, Li, Qianlan, Fu, Keyi, Liu, Haifeng, Zhong, Zhijun, Fu, Hualin, Ren, Zhihua, Gu, Wuyang, and Peng, Guangneng

Subjects
ORAL vaccines, BIRTH control, SPECIES specificity, ORAL contraceptives, VACCINATION coverage
Abstract

The overabundant populations of wildlife have caused many negative impacts, such as human‐wildlife conflicts and ecological degradation. The existing approaches like injectable immunocontraceptive vaccines and lethal methods have limitations in many aspects, which has prompted the advancement of oral immunocontraceptive vaccine. There is growing interest in oral immunocontraceptive vaccines for reasons including high immunization coverage, easier administration, frequent boosting, the ability to induce systemic and mucosal immune responses, and cost‐effectiveness. Delivery systems have been developed to protect oral antigens and enhance the immunogenicity, including live vectors, microparticles and nanoparticles, bacterial ghosts, and mucosal adjuvants. However, currently, no effective oral immunocontraceptive vaccine is available for field trials because of the enormous development challenges, including biological and physicochemical barriers of the gastrointestinal tract, mucosal tolerance, pre‐existing immunity, antigen residence time in the small intestine, species specificity and other safety issues. To overcome these challenges, this article summarizes achievements in delivery systems and contraceptive antigens in oral immunocontraceptive vaccines and explores the potential barriers for future vaccine design and application. [ABSTRACT FROM AUTHOR]

Published
2023
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18. Multiomics Reveals Mechanisms of Alternaria oxytropisInhibiting Pathogenic Fungi in Oxytropis ochrocephala

Author

Fu, Keyi, Schardl, Christopher L., Cook, Daniel, Cao, Xuanli, ling, Ning, He, Chunyu, Wu, Dandan, Xue, Longhai, Li, Yanzhong, and Shi, Zunji

Abstract

Endophytic fungi can benefit the host plant and increase the plant resistance. Now, there is no in-depth study of how Alternaria oxytropis(A. oxytropis) is enhancing the ability of inhibiting pathogenic fungi in Oxytropis ochrocephala(O. ochrocephala). In this study, the fungal community and metabolites associated with endophyte-infected (EI) and endophyte-free (EF) O. ochrocephalawere compared by multiomics. The fungal community indicated that there was more A. oxytropis, less phylum Ascomycota, and less genera Leptosphaeria, Colletotrichum, and Comoclathrisin the EI group. As metabolic biomarkers, the levels of swainsonine and apigenin-7-O-glucoside-4-O-rutinoside were significantly increased in the EI group. Through in vitro validation experiments, swainsonine and apigenin-7-O-glucoside-4-O-rutinoside can dramatically suppress the growth of pathogenic fungi Leptosphaeria sclerotioidesand Colletotrichum americae-borealisby increasing the level of oxidative stress. This work suggested that O. ochrocephalacontaining A. oxytropiscould increase the resistance to fungal diseases by markedly enhancing the content of metabolites inhibiting pathogenic fungi.

Published
2024
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