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5. Neonates undergoing pyloric stenosis repair are at increased risk of difficult airway management: secondary analysis of the NEonate and Children audiT of Anaesthesia pRactice IN Europe

Author

Breschan, Christian, Likar, Rudolf, Platzer, Manuela, Edelman, Isole, Eger, Johanes, Heschl, Stefan, Messerer, Brigitte, Vittinghof, Maria, Kroess, Ruth, Stichlberger, Martina, Kahn, David, Pirotte, Thierry, Pregardien, Caroline, Veyckemans, Francis, Stevens, France, Berghmans, Johan, Bauters, Annemie, De Baerdemaeker, Luc, De Hert, Stefan, Lapage, Koen, Parashchanka, Aliaksandra, Van Limmen, Jurgen, Wyffels, Piet, Lauweryns, Julie, Najafi, Nadia, Vundelinckx, Joris, Butković, Diana, Sorić, Ivana Kerovec, Kralik, Sandra, Markić, Ana, Azman, Josip, Markic, Josko, Pupacic, Daniela, Frelich, Michal, Reimer, Petr, Urbanec, René, Cajková, Petra, Mixa, Vladimír, Sedláčková, Yvona, Knoppová, Lenka, Zlámalová (neé Květoňová), Alena, Vavřina, Martin, Žurek, Jiří, Hansen, Tom, Afshari, Arash, Bille, Anders Bastholm, Ellekvist, Marguerite, Ilmoja, Mari-Liis, Moor, Reet, Kikas, Reet, Väli, Merle, Kallio, Kariantti, Reponen, Elisa, Suominen, Pertti, Suvanto, Sami, Vähätalo, Raisa, Kokki, Hannu, Kokki, Merja, Harju, Jarkko, Kokkonen, Miia, Vieri, Jenni, Manner, Tuula, Catherine, Amory, Ludot, Hugues, Bert, Dina, Godart, Juliette, Laffargue, Anne, Dupont, Hervé, Urbina, Benjamin, Baujard, Catherine, Roulleau, Philippe, Staiti, Giuseppe, Bordes, Maryline, Gaulain, Karine Nouette, Hamonic, Yann, Semjen, François, Jacqmarcq, Olivier, Lejus-Bourdeau Cécile Magne, Caroline, Petry, Léa, Ros, Lilica, Zang, Aurélien, Bennis, Mehdi, Coustets, Bernard, Fesseau, Rose, Constant, Isabelle, Khalil, Eliane, Sabourdin, Nada, Audren, Noemie, Descarpentries, Thomas, Fabre, Fanny, Legrand, Aurélien, Druot, Emilie, Orliaguet, Gilles, Sabau, Lucie, Uhrig, Lynn, Brière, François de la, Jonckheer, Karin, Mission, Jean-Paul, Scordo, Lucia, Couchepin, Caroline, Dadure, Christophe, De la Arena, Pablo, Hertz, Laurent, Pirat, Philippe, Sola, Chrystelle, Bellon, Myriam, Dahmani, Souhayl, Julien-Marsollier, Florence, Michelet, Daphne, Depret-Donatien, Veronique, Lesage, Anne, Kaufmann, Jost, Laschat, Michael, Wappler, Frank, Becke, Karin, Brunner, Lena, Oppenrieder, Karin, Badelt, Gregor, Hochmuth, Karin, Koller, Bernhard, Reil, Anita, Richter, Sebastian, Fischer, Thomas, Diers, Anja, Schorer, Clemens, Weyland, Andreas, Cohausz, Ruth, Kretz, Franz-Josef, Löffler, Michaela, Wilbs, Markus, Hoehne, Claudia, Ulrici, Johanna, Goeters, Christiane, Flinspach, Armin, Klages, Matthias, Lindau, Simone, Messroghli, Leila, Zacharowski, Kai, Eisner, Christoph, Mueller, Thomas, Richter, Daniel, Schäfer, Melanie, Weigand, Markus, Weiterer, Sebastian, Ochsenreiter, Miriam, Schöler, Michael, Terboven, Tom, Eggemann, Isabel, Haussmann, Sascha, Leister, Nicolas, Menzel, Christoph, Trieschmann, Uwe, Yücetepe, Sirin, Keilig, Susanna, Kranke, Peter, Jelting, Yvonne, Baehner, Torsten, Ellerkmann, Richard, Ghamari, Shahab, Neumann, Claudia, Söhle, Martin, Chloropoulou, Pelagia, Ntritsou, Vagia, Papagiannopoulou, Pinelopi, Garini, Eleana, Karafotia, Afroditi, Mammi, Panagoula, Bali, Evangelia, Iordanidou, Despoina, Malisiova, Anna, Polyzoi, Artemis, Tsiotou, Adelais, Sapi, Erzsebet, Székely, Edgar, Kosik, Nandor, Maráczi, Veronika, Schnur, Janos, Csillag, Judit, Gál, János, Göbl, Gergely, Hauser, Balázs, Petróczy, András, Tövisházi, Gyula, Blain, Stuart, Gallagher, Sarah, Harte, Sinead, Jackson, Mandy, Meehan, Emma, Nawoor, Zeenat, O’Hare, Brendan, Ross, Mark, Lerro, Daniela, Astuto, Marinella, Grasso, Chiara, Scalisi, Rita, Frasacco, Giulia, Lenares, Elena, Leone, Roberto, Grazzini, Maurizia, Minardi, Carmelo, Zadra, Nicola, Cinnella, Gilda, Cotoia, Antonella, Galante, Dario, De Lorenzo, Brita, Kuppers, Beate, Bottazzi, Giulia, Caramelli, Fabio, Mondardini, Maria Cristina, Rossetti, Emanuele, Picardo, Sergio, Vittori, Alessandro, Camporesi, Anna, Izzo, Francesca, Calderini, Edoardo, Colantonio, Laura Brigitta, Finamore, Simona Anna, Porro, Giuliana Anna, Bonfiglio, Rachele, Disma, Nicola, Kotzeva, Svetlana, Mattioli, Girolamo, Micalizzi, Camilla, Montaguti, Alessia, Pistorio, Angela, Guddo, Anna, Neba, Gerald Rogan, Favarato, Moreno, Locatelli, Bruno Guido, Maffioletti, Micol, Sonzogni, Valter, Garra, Rossella, Sammartino, Maria, Sbaraglia, Fabio, Cortegiani, Andrea, Moscarelli, Alessandra, Attanasi, Elena, Tesoro, Simonetta, Agapiti, Cristina, Pinzoni, Francesca, Vezzoli, Cesare, Federico, Bilotta, Barzdina, Arta, Straume, Zane, Zundane, Anda, Lukosiene, Laura, Maraulaite, Irena, Razlevice, Ilona, Schmitz, Bernd, Mifsud, Stephanie, Aehling, Carolin, Allison, Celia, De Boer, Rients, Emal, Dina, Stevens, Markus, Buitenhuis, Marielle, de Graaff, Jurgen, De Liefde, Inge, Machotta, Andreas, Scoones, Gail, Staals, Lonneke, Tomas, Jeremy, Van der Knijff-van Dortmont, Anouk, Veldhuizen, Marianne, Alders, David, Schafrat, Eva, Schreiber, Jan, Vermeulen, Petronella Mari, Hendriks, Mark, Lako, Sandra, Voet-Lindner, Marieke, Pieters, Barbe, Scheffer, Gert-Jan, Tielens, Luc, Absalom, Anthony R., Bergsma, Margot, De Ruiter, Joke, Meier, Sascha, Volkers, Martin, Zweers, Tjerk, Beukers, Anne M., Boer, Christa, Dertinger, Jurgen, Numan, Sandra, Van Zaane, Bas, Boerke, Wenche B., Ekiz, Nil, Stensrud, Kristoffer, Drage, Inger Marie, Isern, Erik Ramon, Bartkowska-Sniatkowska, Alicja, Grzeskowiak, Malgorzata, Juzwa-Sobieraj, Magdalena, Rosada-Kurasińska, Jowita, Baranowski, Artur, Jakubowska, Karina, Lewandowska, Dorota, Mierzewska-Schmidt, Magdalena, Sawicki, Piotr, Urban-Lechowicz, Magdalena, Przemyslaw, Pomianek, Zielinska, Marzena, Leal, Teresa, Soares, Maria, Pina, Pedro, Pinho, Sílvia, Patuleia, Maria Domingas, Esteves, Catarina Cruz, Salgado, Helena, Santos, Maria João, Badeti, Rodica, Cindea, Iulia, Oana, Loredana, Gurita, Adriana, Ilie, Luminita, Mocioiu, Gabriel, Tabacaru, Radu, Trante, Irina, Munteanu, Valentin, Morariu, Mihai, Nyíri, Emese, Budic, Ivana, Marjanovic, Vesna, Drašković, Biljana, Pandurov, Marina, Ilic, Jordanka, Mandras, Ana, Rados, Zdenka, Stankovic, Nikola, Suica, Maja, Vasiljevic, Sladjana, Knezevic, Mirjana, Milojevic, Irina, Petrov, Ivana, Racic, Selena Puric, Simic, Dusica, Simic, Irena, Stevic, Marija, Vulicevic, Irena, Bystrica, Banská, Cabanová, Barbora, Hanula, Miloslav, Berger, Jelena, Janjatovic, Darja, Štupnik, Špela Pirtovšek, Méndez, Dolores, Pino, Gema, Rubio, Paloma, Izquierdo, Alberto, López, Silvia, Serrano, Cristina González, Cebrián, Jesús, Peleteiro, Ana, Del Rey de Diego, Pilar, García, Ernesto Martínez, Tormo de las Heras, Carolina, Montero, Pablo Troncoso, Arbona, Celia, Artés, David, Chamizo, Alicia, Serrano, Silvia, Comas, Montserrat Suarez, Escribá, Francisco, Auli, Cristina, Pardo, Osvaldo Pérez, Biddle, Natalia Sierra, Castaño, Ceferina Suárez, Villalobos Rico, María Isabel, Muñoz, Susana Manrique, Martínez, Irene García, Estruch, Nuria Montferrer, Ortíz, Elena Vilardell, Poves-Álvarez, Rodrigo, Kohn, Ivan, Lindestam, Ulf, Reinhard, Jarl, Castellheim, Albert, Sandström, Kerstin, Bengt, Sporre, Dörenberg, Rainer, Frykholm, Peter, Garcia, Maria, Kvarnström, Ann, Pontén, Emma, Bruelisauer, Thomas, Erdoes, Gabor, Kaiser, Heiko, Marchon, Mathias, Riva, Thomas, Seiler, Stefan, Bögli, Yann, Dolci, Mirko, Marcucci, Carine, Habre, Walid, Pichon, Isabelle, Vutskits, Laszlo, Casutt, Mattias, Hölzle, Martin, Hurni, Thomas, Jöhr, Martin, Malär, Anna-Ursina, Mauch, Jacqueline, Erb, Thomas, Oeinck, Karin, Akin, Mine, Keskin, Gulsen, Senayli, Yesim, Kaya, Guner, Kendigelen, Pinar, Tutuncu, Ayse Çiğdem, Hatipoğlu, Zehra, Özcengiz, Dilek, Erdost, Hale Aksu, Öçmen, Elvan, Olguner, Çimen, Ayanoglu, Hilmi, Dincer, Pelin Corman, Umuroglu, Tumay, Azizoglu, Mustafa, Birbiçer, Handan, Doruk, Nurcan, Sagun, Aslı, Baris, Sibel, Dmytriiev, Dmytro, Kuchi, Sridevi, Masip, Nuria, Brooks, Peter, Hare, Alison, Ahmad, Nargis, Casey, Michelle, De Silva, Sam, Dobby, Nadine, Krishnan, Prakash, Sogbodjor, L. Amaki, Walker, Ellie, Walker, Suellen, King, Stephanie, Nicholson, Katy, Quinney, Michelle, Stevens, Paul, Blevin, Andrew, Giombini, Mariangela, Goonasekera, Chulananda, Adil, Sadia, Bew, Stephanie, Bodlani, Carol, Gilpin, Dan, Jinks, Stephanie, Malarkkan, Nalini, Miskovic, Alice, Pad, Rebecca, Barry, Juliet Wolfe, Abbott, Joy, Armstrong, James, Cooper, Natalie, Crate, Lindsay, Emery, John, James, Kathryn, King, Hannah, Martin, Paul, Catenacci, Stefano Scalia, Bomont, Rob, Smith, Paul, Mele, Sara, Verzelloni, Alessandra, Dix, Philippa, Bell, Graham, Gordeva, Elena, McKee, Lesley, Ngan, Esther, Scheffczik, Jutta, Tan, Li-En, Worrall, Mark, Cassar, Carmel, Goddard, Kevin, Barlow, Victoria, Oshan, Vimmi, Shah, Khairi, Bell, Sarah, Daniels, Lisa, Gandhi, Monica, Pachter, David, Perry, Chris, Robertson, Andrew, Scott, Carmen, Waring, Lynne, Barnes, David, Childs, Sophie, Norman, Joanne, Sunderland, Robin, Julia, Dowell, Prisca, Feijten, Pierre, Harlet, Sarah, Herbineaux, Brigitte, Leva, Benoît, Plichon, Katalin, Virág, Engelhardt, Thomas, Hansen, Tom G., de Graaff, Jurgen C., and Virag, Katalin

Published
2022
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6. Morbidity and mortality after anaesthesia in early life: results of the European prospective multicentre observational study, neonate and children audit of anaesthesia practice in Europe (NECTARINE)

Author

Breschan, Christian, Likar, Rudolf, Platzer, Manuela, Edelman, Isole, Eger, Johanes, Heschl, Stefan, Messerer, Brigitte, Vittinghof, Maria, Kroess, Ruth, Stichlberger, Martina, Kahn, David, Pirotte, Thierry, Pregardien, Caroline, Veyckemans, Francis, Stevens, France, Berghmans, Johan, Bauters, Annemie, De Baerdemaeker, Luc, De Hert, Stefan, Lapage, Koen, Parashchanka, Aliaksandra, Van Limmen, Jurgen, Wyffels, Piet, Lauweryns, Julie, Najafi, Nadia, Vundelinckx, Joris, Butković, Diana, Sorić, Ivana Kerovec, Kralik, Sandra, Markić, Ana, Azman, Josip, Markic, Josko, Pupacic, Daniela, Frelich, Michal, Reimer, Petr, Urbanec, Rene, Cajkova, Petra, Mixa, Vladimir, Sedlačkova, Yvona, Knoppova, Lenka, Zlamalova (nee Květoňova), Alena, Vavřina, Martin, Žurek, Jiři, Hansen, Tom, Afshari, Arash, Bille, Anders B., Ellekvist, Marguerite, Ilmoja, Mari-Liis, Moor, Reet, Kikas, Reet, Vali, Merle, Kallio, Kariantti, Reponen, Elisa, Suominen, Pertti, Suvanto, Sami, Vahatalo, Raisa, Kokki, Hannu, Kokki, Merja, Harju, Jarkko, Kokkonen, Miia, Vieri, Jenni, Manner, Tuula, Amory, Catherine, Ludot, Hugues, Bert, Dina, Godart, Juliette, Laffargue, Anne, Dupont, Herve, Urbina, Benjamin, Baujard, Catherine, Roulleau, Philippe, Staiti, Giuseppe, Bordes, Maryline, Gaulain, Karine Nouette, Hamonic, Yann, Semjen, Francois, Jacqmarcq, Olivier, Lejus-Bourdeau, Caroline, Magne, Cecile, Petry, Lea, Ros, Lilica, Zang, Aurelien, Bennis, Mehdi, Coustets, Bernard, Fesseau, Rose, Constant, Isabelle, Khalil, Eliane, Sabourdin, Nada, Audren, Noemie, Descarpentries, Thomas, Fabre, Fanny, Legrand, Aurelien, Druot, Emilie, Orliaguet, Gilles, Sabau, Lucie, Uhrig, Lynn, de la Briere, Francois, Jonckheer, Karin, Mission, Jean-Paul, Scordo, Lucia, Couchepin, Caroline, Dadure, Christophe, De la Arena, Pablo, Hertz, Laurent, Pirat, Philippe, Sola, Chrystelle, Bellon, Myriam, Dahmani, Souhayl, Julien-Marsollier, Florence, Michelet, Daphne, Depret-Donatien, Veronique, Lesage, Anne, Kaufmann, Jost, Laschat, Michael, Wappler, Frank, Becke, Karin, Brunner, Lena, Oppenrieder, Karin, Badelt, Gregor, Hochmuth, Karin, Koller, Bernhard, Reil, Anita, Richter, Sebastian, Fischer, Thomas, Diers, Anja, Schorer, Clemens, Weyland, Andreas, Cohausz, Ruth, Kretz, Franz-Josef, Loffler, Michaela, Wilbs, Markus, Hoehne, Claudia, Ulrici, Johanna, Goeters, Christiane, Flinspach, Armin, Klages, Matthias, Lindau, Simone, Messroghli, Leila, Zacharowski, Kai, Eisner, Christoph, Mueller, Thomas, Richter, Daniel, Schafer, Melanie, Weigand, Markus, Weiterer, Sebastian, Ochsenreiter, Miriam, Scholer, Michael, Terboven, Tom, Eggemann, Isabel, Haussmann, Sascha, Leister, Nicolas, Menzel, Christoph, Trieschmann, Uwe, Yucetepe, Sirin, Keilig, Susanna, Kranke, Peter, Jelting, Yvonne, Baehner, Torsten, Ellerkmann, Richard, Ghamari, Shahab, Neumann, Claudia, Sohle, Martin, Chloropoulou, Pelagia, Ntritsou, Vagia, Papagiannopoulou, Pinelopi, Garini, Eleana, Karafotia, Afroditi, Mammi, Panagoula, Bali, Evangelia, Iordanidou, Despoina, Malisiova, Anna, Polyzoi, Artemis, Tsiotou, Adelais, Sapi, Erzsebet, Szekely, Edgar, Kosik, Nandor, Maraczi, Veronika, Schnur, Janos, Csillag, Judit, Gal, Janos, Gobl, Gergely, Hauser, Balazs, Petroczy, Andras, Tovishazi, Gyula, Blain, Stuart, Gallagher, Sarah, Harte, Sinead, Jackson, Mandy, Meehan, Emma, Nawoor, Zeenat, O’Hare, Brendan, Ross, Mark, Lerro, Daniela, Astuto, Marinella, Grasso, Chiara, Scalisi, Rita, Frasacco, Giulia, Lenares, Elena, Leone, Roberto, Grazzini, Maurizia, Minardi, Carmelo, Zadra, Nicola, Cinnella, Gilda, Cotoia, Antonella, Galante, Dario, De Lorenzo, Brita, Kuppers, Beate, Bottazzi, Giulia, Caramelli, Fabio, Mondardini, Maria C., Rossetti, Emanuele, Picardo, Sergio, Vittori, Alessandro, Camporesi, Anna, Wolfler, Andrea, Calderini, Edoardo, Colantonio, Laura B., Finamore, Simona A., Porro, Giuliana A., Bonfiglio, Rachele, Disma, Nicola, Kotzeva, Svetlana, Mameli, Leila, Mattioli, Girolamo, Micalizzi, Camilla, Montaguti, Alessia, Pistorio, Angela, Zanaboni, Clelia, Guddo, Anna, Neba, Gerald R., Favarato, Moreno, Locatelli, Bruno G., Maffioletti, Micol, Sonzogni, Valter, Garra, Rossella, Sammartino, Maria, Sbaraglia, Fabio, Cortegiani, Andrea, Moscarelli, Alessandra, Attanasi, Elena, Tesoro, Simonetta, Agapiti, Cristina, Pinzoni, Francesca, Vezzoli, Cesare, Bilotta, Federico, Barzdina, Arta, Straume, Zane, Zundane, Anda, Lukosiene, Laura, Maraulaite, Irena, Razlevice, Ilona, Schmitz, Bernd, Mifsud, Stephanie, Aehling, Carolin, Allison, Celia, De Boer, Rients, Emal, Dina, Stevens, Markus, Buitenhuis, Marielle, de Graaff, Jurgen, De Liefde, Inge, Machotta, Andreas, Scoones, Gail, Staals, Lonneke, Tomas, Jeremy, Van der, Anouk, Dortmont, Knijff-van, Veldhuizen, Marianne, Alders, David, Buhre, Wolfgang, Schafrat, Eva, Schreiber, Jan, Vermeulen, Petronella M., Hendriks, Mark, Lako, Sandra, Voet-Lindner, Marieke, Pieters, Barbe, Scheffer, Gert-Jan, Tielens, Luc, Absalom, Anthony R., Bergsma, Margot, De Ruiter, Joke, Meier, Sascha, Volkers, Martin, Zweers, Tjerk, Beukers, Anne M., Boer, Christa, Dertinger, Jurgen, Numan, Sandra, Van Zaane, Bas, Boerke, Wenche B., Ekiz, Nil, Stensrud, Kristoffer, Drage, Inger M., Isern, Erik R., Bartkowska-Sniatkowska, Alicja, Grzeskowiak, Malgorzata, Juzwa-Sobieraj, Magdalena, Rosada-Kurasińska, Jowita, Baranowski, Artur, Jakubowska, Karina, Lewandowska, Dorota, Mierzewska-Schmidt, Magdalena, Sawicki, Piotr, Urban-Lechowicz, Magdalena, Przemyslaw, Pomianek, Zielinska, Marzena, Leal, Teresa, Soares, Maria, Pina, Pedro, Pinho, Silvia, Patuleia, Maria Domingas, Esteves, Catarina C., Salgado, Helena, Santos, Maria J., Badeti, Rodica, Cindea, Iulia, Oana, Loredana, Gurita, Adriana, Ilie, Luminita, Mocioiu, Gabriel, Tabacaru, Radu, Trante, Irina, Munteanu, Valentin, Morariu, Mihai, Nyiri, Emese, Budic, Ivana, Marjanovic, Vesna, Drašković, Biljana, Pandurov, Marina, Ilic, Jordanka, Mandras, Ana, Rados, Zdenka, Stankovic, Nikola, Suica, Maja, Vasiljevic, Sladjana, Knezevic, Mirjana, Milojevic, Irina, Petrov, Ivana, Racic, Selena Puric, Simic, Dusica, Simic, Irena, Stevic, Marija, Vulicevic, Irena, Cabanova, Barbora, Hanula, Miloslav, Berger, Jelena, Janjatovic, Darja, Štupnik, Špela P., Kohn, Ivan, Lindestam, Ulf, Reinhard, Jarl, Castellheim, Albert, Sandstrom, Kerstin, Bengt, Sporre, Dorenberg, Rainer, Frykholm, Peter, Garcia, Maria, Kvarnstrom, Ann, Ponten, Emma, Bruelisauer, Thomas, Erdoes, Gabor, Kaiser, Heiko, Marchon, Mathias, Riva, Thomas, Seiler, Stefan, Bogli, Yann, Dolci, Mirko, Marcucci, Carine, Habre, Walid, Pichon, Isabelle, Vutskits, Laszlo, Casutt, Mattias, Holzle, Martin, Hurni, Thomas, Johr, Martin, Anna-Ursina, Malar, Mauch, Jacqueline, Erb, Thomas, Oeinck, Karin, Akin, Mine, Keskin, Gulsen, Senayli, Yesim, Kaya, Guner, Kendigelen, Pinar, Tutuncu, Ayse C., Hatipoğlu, Zehra, Ozcengiz, Dilek, Erdost, Hale Aksu, Ocmen, Elvan, Olguner, Cimen, Ayanoglu, Hilmi, Dincer, Pelin C., Umuroglu, Tumay, Azizoglu, Mustafa, Birbicer, Handan, Doruk, Nurcan, Sagun, Aslı, Baris, Sibel, Dmytriiev, Dmytro, Kuchi, Sridevi, Masip, Nuria, Brooks, Peter, Hare, Alison, Ahmad, Nargis, Casey, Michelle, De Silva, Sam, Dobby, Nadine, Krishnan, Prakash, Sogbodjor, L. Amaki, Walker, Ellie, Walker, Suellen, King, Stephanie, Nicholson, Katy, Quinney, Michelle, Stevens, Paul, Blevin, Andrew, Giombini, Mariangela, Goonasekera, Chulananda, Adil, Sadia, Bew, Stephanie, Bodlani, Carol, Gilpin, Dan, Jinks, Stephanie, Malarkkan, Nalini, Miskovic, Alice, Pad, Rebecca, Barry, Juliet W., Abbott, Joy, Armstrong, James, Cooper, Natalie, Crate, Lindsay, Emery, John, James, Kathryn, King, Hannah, Martin, Paul, Catenacci, Stefano S., Bomont, Rob, Smith, Paul, Mele, Sara, Verzelloni, Alessandra, Dix, Philippa, Bell, Graham, Gordeva, Elena, McKee, Lesley, Ngan, Esther, Scheffczik, Jutta, Tan, Li-En, Worrall, Mark, Cassar, Carmel, Goddard, Kevin, Barlow, Victoria, Oshan, Vimmi, Shah, Khairi, Bell, Sarah, Daniels, Lisa, Gandhi, Monica, Pachter, David, Perry, Chris, Robertson, Andrew, Scott, Carmen, Waring, Lynne, Barnes, David, Childs, Sophie, Norman, Joanne, Sunderland, Robin, Virag, Katalin, Hansen, Tom G., Harlet, Pierre, Walker, Suellen M., de Graaff, Jurgen C., and Engelhardt, Thomas

Published
2021
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7. Difficult tracheal intubation in neonates and infants. NEonate and Children audiT of Anaesthesia pRactice IN Europe (NECTARINE): a prospective European multicentre observational study

Author

Breschan, Christian, Likar, Rudolf, Platzer, Manuela, Edelman, Isole, Eger, Johanes, Heschl, Stefan, Messerer, Brigitte, Vittinghof, Maria, Kroess, Ruth, Stichlberger, Martina, Kahn, David, Pirotte, Thierry, Pregardien, Caroline, Veyckemans, Francis, Stevens, France, Berghmans, Johan, Bauters, Annemie, De Baerdemaeker, Luc, De Hert, Stefan, Lapage, Koen, Parashchanka, Aliaksandra, Van Limmen, Jurgen, Wyffels, Piet, Lauweryns, Julie, Najafi, Nadia, Vundelinckx, Joris, Butković, Diana, Kerovec Sorić, Ivana, Kralik, Sandra, Markić, Ana, Azman, Josip, Markic, Josko, Pupacic, Daniela, Frelich, Michal, Reimer, Petr, Urbanec, René, Cajková, Petra, Mixa, Vladimír, Sedláčková, Yvona, Knoppová, Lenka, Zlámalová (neé Květoňová), Alena, Vavřina, Martin, Žurek, Jiří, Hansen, Tom, Afshari, Arash, Bille, Anders Bastholm, Ellekvist, Marguerite, Ilmoja, Mari-Liis, Moor, Reet, Kikas, Reet, Väli, Merle, Kallio, Kariantti, Reponen, Elisa, Suominen, Pertti, Suvanto, Sami, Vähätalo, Raisa, Kokki, Hannu, Kokki, Merja, Harju, Jarkko, Kokkonen, Miia, Vieri, Jenni, Manner, Tuula, Amory, Catherine, Ludot, Hugues, Bert, Dina, Godart, Juliette, Laffargue, Anne, Dupont, Hervé, Urbina, Benjamin, Baujard, Catherine, Roulleau, Philippe, Staiti, Giuseppe, Bordes, Maryline, Nouette Gaulain, Karine, Hamonic, Yann, Semjen, François, Jacqmarcq, Olivier, Lejus-Bourdeau, Caroline, Magne, Cécile, Petry, Léa, Ros, Lilica, Zang, Aurélien, Bennis, Mehdi, Coustets, Bernard, Fesseau, Rose, Constant, Isabelle, Khalil, Eliane, Sabourdin, Nada, Audren, Noemie, Descarpentries, Thomas, Fabre, Fanny, Legrand, Aurélien, Druot, Emilie, Orliaguet, Gilles, Sabau, Lucie, Uhrig, Lynn, de la Brière, François, Jonckheer, Karin, Mission, Jean-Paul, Scordo, Lucia, Couchepin, Caroline, Dadure, Christophe, De la Arena, Pablo, Hertz, Laurent, Pirat, Philippe, Sola, Chrystelle, Bellon, Myriam, Dahmani, Souhayl, Julien-Marsollier, Florence, Michelet, Daphne, Depret-Donatien, Veronique, Lesage, Anne, Kaufmann, Jost, Laschat, Michael, Wappler, Frank, Becke, Karin, Brunner, Lena, Oppenrieder, Karin, Badelt, Gregor, Hochmuth, Karin, Koller, Bernhard, Reil, Anita, Richter, Sebastian, Fischer, Thomas, Diers, Anja, Schorer, Clemens, Weyland, Andreas, Cohausz, Ruth, Kretz, Franz-Josef, Löffler, Michaela, Wilbs, Markus, Hoehne, Claudia, Ulrici, Johanna, Goeters, Christiane, Flinspach, Armin, Klages, Matthias, Lindau, Simone, Messroghli, Leila, Zacharowski, Kai, Eisner, Christoph, Mueller, Thomas, Richter, Daniel, Schäfer, Melanie, Weigand, Markus, Weiterer, Sebastian, Ochsenreiter, Miriam, Schöler, Michael, Terboven, Tom, Eggemann, Isabel, Haussmann, Sascha, Leister, Nicolas, Menzel, Christoph, Trieschmann, Uwe, Yücetepe, Sirin, Keilig, Susanna, Kranke, Peter, Jelting, Yvonne, Baehner, Torsten, Ellerkmann, Richard, Ghamari, Shahab, Neumann, Claudia, Söhle, Martin, Chloropoulou, Pelagia, Ntritsou, Vagia, Papagiannopoulou, Pinelopi, Garini, Eleana, Karafotia, Afroditi, Mammi, Panagoula, Bali, Evangelia, Iordanidou, Despoina, Malisiova, Anna, Polyzoi, Artemis, Tsiotou, Adelais, Sapi, Erzsebet, Székely, Edgar, Kosik, Nandor, Maráczi, Veronika, Schnur, Janos, Csillag, Judit, Gál, János, Göbl, Gergely, Hauser, Balázs, Petróczy, András, Tövisházi, Gyula, Blain, Stuart, Gallagher, Sarah, Harte, Sinead, Jackson, Mandy, Meehan, Emma, Nawoor, Zeenat, O’Hare, Brendan, Ross, Mark, Lerro, Daniela, Astuto, Marinella, Grasso, Chiara, Scalisi, Rita, Frasacco, Giulia, Lenares, Elena, Leone, Roberto, Grazzini, Maurizia, Minardi, Carmelo, Zadra, Nicola, Cinnella, Gilda, Cotoia, Antonella, Galante, Dario, De Lorenzo, Brita, Kuppers, Beate, Bottazzi, Giulia, Caramelli, Fabio, Mondardini, Maria Cristina, Rossetti, Emanuele, Picardo, Sergio, Vittori, Alessandro, Camporesi, Anna, Wolfler, Andrea, Calderini, Edoardo, Colantonio, Laura Brigitta, Finamore, Simona Anna, Porro, Giuliana Anna, Bonfiglio, Rachele, Disma, Nicola, Kotzeva, Svetlana, Mameli, Leila, Mattioli, Girolamo, Micalizzi, Camilla, Montaguti, Alessia, Pistorio, Angela, Zanaboni, Clelia, Guddo, Anna, Neba, Gerald Rogan, Favarato, Moreno, Locatelli, Bruno Guido, Maffioletti, Micol, Sonzogni, Valter, Garra, Rossella, Sammartino, Maria, Sbaraglia, Fabio, Cortegiani, Andrea, Moscarelli, Alessandra, Attanasi, Elena, Tesoro, Simonetta, Agapiti, Cristina, Pinzoni, Francesca, Vezzoli, Cesare, Bilotta, Federico, Barzdina, Arta, Straume, Zane, Zundane, Anda, Lukosiene, Laura, Maraulaite, Irena, Razlevice, Ilona, Schmitz, Bernd, Mifsud, Stephanie, Aehling, Carolin, Allison, Celia, De Boer, Rients, Emal, Dina, Stevens, Markus, Buitenhuis, Marielle, de Graaff, Jurgen, De Liefde, Inge, Machotta, Andreas, Scoones, Gail, Staals, Lonneke, Tomas, Jeremy, Van der Knijff-van Dortmont, Anouk, Veldhuizen, Marianne, Alders, David, Buhre, Wolfgang, Schafrat, Eva, Schreiber, Jan, Vermeulen, Petronella Mari, Hendriks, Mark, Lako, Sandra, Voet-Lindner, Marieke, Pieters, Barbe, Scheffer, Gert-Jan, Tielens, Luc, Absalom, Anthony R., Bergsma, Margot, De Ruiter, Joke, Meier, Sascha, Volkers, Martin, Zweers, Tjerk, Beukers, Anne M., Boer, Christa, Dertinger, Jurgen, Numan, Sandra, Van Zaane, Bas, Boerke, Wenche B., Ekiz, Nil, Stensrud, Kristoffer, Drage, Inger Marie, Isern, Erik Ramon, Bartkowska-Sniatkowska, Alicja, Grzeskowiak, Malgorzata, Juzwa-Sobieraj, Magdalena, Rosada-Kurasińska, Jowita, Baranowski, Artur, Jakubowska, Karina, Lewandowska, Dorota, Mierzewska-Schmidt, Magdalena, Sawicki, Piotr, Urban-Lechowicz, Magdalena, Przemyslaw, Pomianek, Zielinska, Marzena, Leal, Teresa, Soares, Maria, Pina, Pedro, Pinho, Sílvia, Patuleia, Maria Domingas, Esteves, Catarina Cruz, Salgado, Helena, Santos, Maria João, Badeti, Rodica, Cindea, Iulia, Oana, Loredana, Gurita, Adriana, Ilie, Luminita, Mocioiu, Gabriel, Tabacaru, Radu, Trante, Irina, Munteanu, Valentin, Morariu, Mihai, Nyíri, Emese, Budic, Ivana, Marjanovic, Vesna, Drašković, Biljana, Pandurov, Marina, Ilic, Jordanka, Mandras, Ana, Rados, Zdenka, Stankovic, Nikola, Suica, Maja, Vasiljevic, Sladjana, Knezevic, Mirjana, Milojevic, Irina, Petrov, Ivana, Puric Racic, Selena, Simic, Dusica, Simic, Irena, Stevic, Marija, Vulicevic, Irena, Cabanová, Barbora, Hanula, Miloslav, Berger, Jelena, Janjatovic, Darja, Pirtovšek Štupnik, Špela, Méndez, Dolores, Pino, Gema, Rubio, Paloma, Izquierdo, Alberto, López, Silvia, González Serrano, Cristina, Cebrián, Jesús, Peleteiro, Ana, Del Rey de Diego, Pilar, Martínez García, Ernesto, Tormo de las Heras, Carolina, Troncoso Montero, Pablo, Arbona, Celia, Artés, David, Chamizo, Alicia, Serrano, Silvia, Suarez Comas, Montserrat, Escribá, Francisco, Auli, Cristina, Pérez Pardo, Osvaldo, Sierra Biddle, Natalia, Suárez Castaño, Ceferina, Villalobos Rico, María Isabel, Manrique Muñoz, Susana, García Martínez, Irene, Montferrer Estruch, Nuria, Vilardell Ortíz, Elena, Poves-Álvarez, Rodrigo, Kohn, Ivan, Lindestam, Ulf, Reinhard, Jarl, Castellheim, Albert, Sandström, Kerstin, Bengt, Sporre, Dörenberg, Rainer, Frykholm, Peter, Garcia, Maria, Kvarnström, Ann, Pontén, Emma, Bruelisauer, Thomas, Erdoes, Gabor, Kaiser, Heiko, Marchon, Mathias, Riva, Thomas, Seiler, Stefan, Bögli, Yann, Dolci, Mirko, Marcucci, Carine, Habre, Walid, Pichon, Isabelle, Vutskits, Laszlo, Casutt, Mattias, Hölzle, Martin, Hurni, Thomas, Jöhr, Martin, Malär, Anna-Ursina, Mauch, Jacqueline, Erb, Thomas, Oeinck, Karin, Akin, Mine, Keskin, Gulsen, Senayli, Yesim, Kaya, Guner, Kendigelen, Pinar, Tutuncu, Ayse Çiğdem, Hatipoğlu, Zehra, Özcengiz, Dilek, Erdost, Hale Aksu, Öçmen, Elvan, Olguner, Çimen, Ayanoglu, Hilmi, Dincer, Pelin Corman, Umuroglu, Tumay, Azizoglu, Mustafa, Birbiçer, Handan, Doruk, Nurcan, Sagun, Aslı, Baris, Sibel, Dmytriiev, Dmytro, Kuchi, Sridevi, Masip, Nuria, Brooks, Peter, Hare, Alison, Ahmad, Nargis, Casey, Michelle, De Silva, Sam, Dobby, Nadine, Krishnan, Prakash, Sogbodjor, L. Amaki, Walker, Ellie, Walker, Suellen, King, Stephanie, Nicholson, Katy, Quinney, Michelle, Stevens, Paul, Blevin, Andrew, Giombini, Mariangela, Goonasekera, Chulananda, Adil, Sadia, Bew, Stephanie, Bodlani, Carol, Gilpin, Dan, Jinks, Stephanie, Malarkkan, Nalini, Miskovic, Alice, Pad, Rebecca, Wolfe Barry, Juliet, Abbott, Joy, Armstrong, James, Cooper, Natalie, Crate, Lindsay, Emery, John, James, Kathryn, King, Hannah, Martin, Paul, Scalia Catenacci, Stefano, Bomont, Rob, Smith, Paul, Mele, Sara, Verzelloni, Alessandra, Dix, Philippa, Bell, Graham, Gordeva, Elena, McKee, Lesley, Ngan, Esther, Scheffczik, Jutta, Tan, Li-En, Worrall, Mark, Cassar, Carmel, Goddard, Kevin, Barlow, Victoria, Oshan, Vimmi, Shah, Khairi, Bell, Sarah, Daniels, Lisa, Gandhi, Monica, Pachter, David, Perry, Chris, Robertson, Andrew, Scott, Carmen, Waring, Lynne, Barnes, David, Childs, Sophie, Norman, Joanne, Sunderland, Robin, Julia, Dowell, Prisca, Feijten, Pierre, Harlet, Sarah, Herbineaux, Brigitte, Leva, Benoît, Plichon, Katalin, Virág, Virag, Katalin, and Engelhardt, Thomas

Published
2021
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9. Paediatric postoperative acute kidney injury after non‐cardiac surgery: Protocol for a systematic review and meta‐analysis.

Author

Emami, Arash, Sivertsson, Ebba, Westerbergh, Johan, Hultström, Michael, Danielsson, Johan, Frykholm, Peter, and Frithiof, Robert

Subjects
SURGICAL complications, ACUTE kidney failure, CHRONIC kidney failure, CHILD patients, LENGTH of stay in hospitals
Abstract

Background: Paediatric acute kidney injury (AKI) is associated with significant adverse outcomes such as increased mortality, progression to chronic kidney disease and longer length of stay in hospital. Postoperative AKI is a common and recognized complication after surgery in adults. In the paediatric population, AKI postoperatively to cardiac surgery has been extensively studied. However, the incidence of postoperative AKI after non‐cardiac surgery is less clear. Therefore, we aim to assess the available literature on this topic. Methods: We will conduct a systematic review of observational and randomized controlled trials assessing the incidence of paediatric postoperative AKI after non‐cardiac surgery. Pairs of reviewers will independently screen the literature and extract data and assess risk of bias from eligible studies. The databases Pubmed, Cochrane and Web of Sciences will be searched. We will conduct the review in accordance with the Preferred Reporting Items for Systematic Review and Meta‐Analysis (PRISMA) guidelines and the Grading of Recommendation, Assessment, Development and Evaluation (GRADE) approach. If sufficient homogeneity within the included trials we will conduct meta‐analyses. Discussion: This systematic review aims to investigate the incidence of postoperative AKI in the paediatric non‐cardiac surgery population. The results of this review will provide a foundation for future research in the field of paediatric postoperative AKI. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Pediatric anesthesia in Europe: Variations within uniformity.

Author

de Graaff, Jurgen C., Frykholm, Peter, Engelhardt, Thomas, Schindler, Ehrenfried, Kovesi, Tamas, Simic, Dusica, Malagon, Ignacio, Woodman, Natasha, Courtman, Simon, Najafi, Nadia, Claussen, Nicola Groes, Karlsson, Jacob, Bonhomme, Fanny, Laffargue, Anne, and Vutskits, Laszlo

Subjects
*PEDIATRIC anesthesia, *PEDIATRIC therapy, *MEDICAL specialties & specialists, *CHILDREN'S hospitals, *PERIOPERATIVE care
Abstract

Organization of healthcare strongly differs between European countries and results in country‐specific requirements in postgraduate medical training. Within the European Union (EU), the European Board of Anaesthesiology has set recommendations of training for the Specialty of Anaesthesiology including standards for Postgraduate Medical Specialist training including a description for providing service in pediatric anesthesia. However, these standards are advisory and not mandatory. Here we aimed to review the current state and associated challenges of pediatric anesthesia training in Europe. We report an important country‐specific variability both in training and regulations of practice of pediatric anesthesia in the EU and in the United Kingdom. The requirements for training in pediatric anesthesia varies between nothing specified (Belgium) or providing anesthesia with direct supervision to a minimum of 50 cases below 5 years of age (Germany) to 3–6 month clinical practice in a specialized pediatric hospital (France). Likewise, the regulations for providing anesthesia to children varies from no regulations at all (Belgium) to age specific requirements and centralization of all children below 4 years of age to specified centers (United Kingdom). Officially recognized pediatric anesthesia fellowship programs are not available in most countries of Europe. It remains unclear if and how country‐specific differences in pediatric anesthesia training are associated with clinical outcomes in pediatric perioperative care. There is converging interest and support for the establishment of a European pediatric anesthesia curriculum. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Clear rules for clear fluids fasting in children

Author

Disma, Nicola, Frykholm, Peter, Disma, Nicola, and Frykholm, Peter

Abstract

Preoperative fasting guidelines published in 2022 by the European Society of Anaesthesiology and Intensive Care represent a paradigm shift in the preoperative preparation of children undergoing general anaesthesia. Schmitz and colleagues report the results from a multi-institutional prospective cohort study to determine if application of the recent guidelines increased the risk of regurgitation and pulmonary aspiration. This study provides support for the concept of reducing real fasting times by allowing clear fluids until 1 h before induction of anaesthesia. Although the study cohort was large, further prospective multicentre studies with even greater sample sizes are warranted to provide definitive evidence for the safety of the new fasting rules.

Published
2024
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14. Optimal Diagnostic and Treatment Practices for Facial Dysostosis Syndromes:A Clinical Consensus Statement Among European Experts

Author

Van Roey, Victor L., Irvine, Willemijn F.E., Åsten, Pamela Marika, Bouzariouh, Anouar, van Dooren, Marieke, Faasse, Mariët, Frykholm, Peter, Goverde, Anne, van Heesch, Gwen, Heinen, Arnoud, Heliövaara, Arja, Joosten, Koen, Kljajić, Marizela, Larsson, Eva, Loudon, Sjoukje, Marinac, Ivana, Mathijssen, Irene, Munill, Montserrat, Munkhammar, Åsa Alberius, van Nieuwenhoven, Christianne, Poldermans, Henriette, Thierry, Briac, Tjoa, Stephen, Topa, Alexandra, Valvassori, Maria, Versnel, Sarah, Weissbach, Elin, Wolvius, Eppo, Zafra Vallejo, Víctor, Van Roey, Victor L., Irvine, Willemijn F.E., Åsten, Pamela Marika, Bouzariouh, Anouar, van Dooren, Marieke, Faasse, Mariët, Frykholm, Peter, Goverde, Anne, van Heesch, Gwen, Heinen, Arnoud, Heliövaara, Arja, Joosten, Koen, Kljajić, Marizela, Larsson, Eva, Loudon, Sjoukje, Marinac, Ivana, Mathijssen, Irene, Munill, Montserrat, Munkhammar, Åsa Alberius, van Nieuwenhoven, Christianne, Poldermans, Henriette, Thierry, Briac, Tjoa, Stephen, Topa, Alexandra, Valvassori, Maria, Versnel, Sarah, Weissbach, Elin, Wolvius, Eppo, and Zafra Vallejo, Víctor

Abstract

Facial dysostosis syndromes (FDS) are rare congenital conditions impacting facial development, often leading to diverse craniofacial abnormalities. This study addresses the scarcity of evidence on these syndromes about optimal diagnostic and treatment practices. To overcome this scarcity, European experts from ERN CRANIO collaborated to develop a clinical consensus statement through the Delphi consensus method. A systematic search of Embase, MEDLINE/PubMed, Cochrane, and Web of Science databases was conducted until February 2023. The quality of evidence was evaluated using various tools depending on the study design. Statements were subsequently formed based on literature and expert opinion, followed by a Delphi process with expert health care providers and patient representatives. In total, 92 experts from various specialties and three patient representatives were involved in the Delphi process. Over 3 voting rounds, consensus was achieved on 92 (46.9%), 58 (59.2%), and 19 (70.4%) statements, respectively. These statements cover the topics of general care; craniofacial reconstruction; the eyes and lacrimal system; upper airway management; genetics; hearing; speech; growth, feeding, and swallowing; dental treatment and orthodontics; extracranial anomalies; and psychology and cognition. The current clinical consensus statement provides valuable insights into optimal diagnostic and treatment practices and identifies key research opportunities for FDS. This consensus statement represents a significant advancement in FDS care, underlining the commitment of health care professionals to improve the understanding and management of these rare syndromes in Europe.

Published
2024

15. Swedish registry study showed that 50% of paediatric operations were performed in university hospitals and mortality was low

Author

Pelkonen, Ruut-Maria, Frykholm, Peter, Enlund, Gunnar, Lilja, Helene Engstrand, Pelkonen, Ruut-Maria, Frykholm, Peter, Enlund, Gunnar, and Lilja, Helene Engstrand

Abstract

Aim: To investigate the distribution of paediatric surgery in various hospitals and to study postoperative risk factors of mortality. Methods: Retrospective registry-based cohort study of children aged 0-14 years undergoing surgery from 2017 to 2021. Data were extracted from the Swedish Perioperative Registry. A mixed logistic regression was applied for the all-risk mortality analysis. Results: A total of 126 539 cases were identified, 50% in university, 36% in county and 14% in district hospitals. The dominating operations were appendectomy in 6667, orchidopexy in 5287, inguinal hernia repair in 4200 and gastrostomy in 1152 children. Among children under 1 year of age or American Society of Anesthesiologists Physical Status classification (ASA-PS-Class) 3-5, the majority underwent surgery in university hospitals. The 30-day mortality in university hospitals was 0.5% and in county hospitals 0%. The proportion of emergency surgery was similar in university and county hospitals. Independent risk factors of mortality were being under 1 year of age, ASA-PS-class 4-5, emergency surgery and surgery at university hospitals. Conclusion: Half of all operations in children were performed in university hospitals, with low postoperative mortality despite effective centralisation of high risk patients <1 year of age or ASA-PS-Class 3-5.

Published
2024
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16. Lung impedance changes during awake prone positioning in COVID-19 : A non-randomized cross-over study

Author

Rosén, Jacob, Frykholm, Peter, Jonsson Fagerlund, Malin, Pellegrini, Mariangela, Campoccia Jalde, Francesca, von Oelreich, Erik, Fors, Diddi, Rosén, Jacob, Frykholm, Peter, Jonsson Fagerlund, Malin, Pellegrini, Mariangela, Campoccia Jalde, Francesca, von Oelreich, Erik, and Fors, Diddi

Abstract

Background The effects of awake prone positioning (APP) on respiratory mechanics in patients with COVID-19 are not well characterized. The aim of this study was to investigate changes of global and regional lung volumes during APP compared with the supine position using electrical lung impedance tomography (EIT) in patients with hypoxemic respiratory failure due to COVID-19. Materials and methods This exploratory non-randomized cross-over study was conducted at two university hospitals in Sweden between January and May 2021. Patients admitted to the intensive care unit with confirmed COVID-19, an arterial cannula in place, a PaO2/FiO2 ratio <26.6 kPa (<200 mmHg) and high-flow nasal oxygen or non-invasive ventilation were eligible for inclusion. EIT-data were recorded at supine baseline, at 30 and 60 minutes after APP-initiation, and 30 minutes after supine repositioning. The primary outcomes were changes in global and regional tidal impedance variation (TIV), center of ventilation (CoV), global and regional delta end-expiratory lung-impedance (dEELI) and global inhomogeneity (GI) index at the end of APP compared with supine baseline. Data were reported as median (IQR). Results All patients (n = 10) were male and age was 64 (47–73) years. There were no changes in global or regional TIV, CoV or GI-index during the intervention. dEELI increased from supine reference value 0 to 1.51 (0.32–3.62) 60 minutes after APP (median difference 1.51 (95% CI 0.19–5.16), p = 0.04) and returned to near baseline values after supine repositioning. Seven patients (70%) showed an increase >0.20 in dEELI during APP. The other EIT-variables did not change during APP compared with baseline. Conclusion Awake prone positioning was associated with a transient lung recruiting effect without changes in ventilation distribution measured with EIT in patients with hypoxemic respiratory failure due to COVID-19.

Published
2024
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17. Pediatric anesthesia in Europe:Variations within uniformity

Author

de Graaff, Jurgen C., Frykholm, Peter, Engelhardt, Thomas, Schindler, Ehrenfried, Kovesi, Tamas, Simic, Dusica, Malagon, Ignacio, Woodman, Natasha, Courtman, Simon, Najafi, Nadia, Claussen, Nicola Groes, Karlsson, Jacob, Bonhomme, Fanny, Laffargue, Anne, Vutskits, Laszlo, de Graaff, Jurgen C., Frykholm, Peter, Engelhardt, Thomas, Schindler, Ehrenfried, Kovesi, Tamas, Simic, Dusica, Malagon, Ignacio, Woodman, Natasha, Courtman, Simon, Najafi, Nadia, Claussen, Nicola Groes, Karlsson, Jacob, Bonhomme, Fanny, Laffargue, Anne, and Vutskits, Laszlo

Abstract

Organization of healthcare strongly differs between European countries and results in country-specific requirements in postgraduate medical training. Within the European Union (EU), the European Board of Anaesthesiology has set recommendations of training for the Specialty of Anaesthesiology including standards for Postgraduate Medical Specialist training including a description for providing service in pediatric anesthesia. However, these standards are advisory and not mandatory. Here we aimed to review the current state and associated challenges of pediatric anesthesia training in Europe. We report an important country-specific variability both in training and regulations of practice of pediatric anesthesia in the EU and in the United Kingdom. The requirements for training in pediatric anesthesia varies between nothing specified (Belgium) or providing anesthesia with direct supervision to a minimum of 50 cases below 5 years of age (Germany) to 3–6 month clinical practice in a specialized pediatric hospital (France). Likewise, the regulations for providing anesthesia to children varies from no regulations at all (Belgium) to age specific requirements and centralization of all children below 4 years of age to specified centers (United Kingdom). Officially recognized pediatric anesthesia fellowship programs are not available in most countries of Europe. It remains unclear if and how country-specific differences in pediatric anesthesia training are associated with clinical outcomes in pediatric perioperative care. There is converging interest and support for the establishment of a European pediatric anesthesia curriculum.

Published
2024

20. New methods needed to investigate the potential adverse effects of anaesthesia on neurological development in childhood.

Author

Frykholm, Peter and Veyckemans, Francis

Subjects
*CHILD development, *NEUROTOXICOLOGY, *ANESTHESIA, *NEURAL development, *COHORT analysis
Abstract

The issue of potentially harmful effects of neurotoxicity or anaesthesia management on children undergoing general anaesthesia is still not resolved. Studies have so far been limited by methodological problems. In a retrospective cohort study, a new noninvasive method was used to demonstrate visual processing changes in children with a single previous exposure to anaesthesia. We need new noninvasive methods that can be used before and after exposure to anaesthesia and surgery to detemine possible effects on long-term neurodevelopment. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Swedish registry study showed that 50% of paediatric operations were performed in university hospitals and mortality was low.

Author

Pelkonen, Ruut‐Maria, Frykholm, Peter, Enlund, Gunnar, and Lilja, Helene Engstrand

Subjects
*UNIVERSITY hospitals, *HOSPITAL mortality, *PREOPERATIVE risk factors, *HERNIA surgery, *PEDIATRIC surgery, *ORCHIOPEXY, *APPENDECTOMY
Abstract

Aim: To investigate the distribution of paediatric surgery in various hospitals and to study postoperative risk factors of mortality. Methods: Retrospective registry‐based cohort study of children aged 0–14 years undergoing surgery from 2017 to 2021. Data were extracted from the Swedish Perioperative Registry. A mixed logistic regression was applied for the all‐risk mortality analysis. Results: A total of 126 539 cases were identified, 50% in university, 36% in county and 14% in district hospitals. The dominating operations were appendectomy in 6667, orchidopexy in 5287, inguinal hernia repair in 4200 and gastrostomy in 1152 children. Among children under 1 year of age or American Society of Anesthesiologists Physical Status classification (ASA‐PS‐Class) 3–5, the majority underwent surgery in university hospitals. The 30‐day mortality in university hospitals was 0.5% and in county hospitals 0%. The proportion of emergency surgery was similar in university and county hospitals. Independent risk factors of mortality were being under 1 year of age, ASA‐PS‐class 4–5, emergency surgery and surgery at university hospitals. Conclusion: Half of all operations in children were performed in university hospitals, with low postoperative mortality despite effective centralisation of high risk patients <1 year of age or ASA‐PS‐Class 3–5. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Case series of peripherally inserted central catheter insertion in young children: A new approach to the axillary vein.

Author

Frykholm, Peter, Modiri, Ali‐Reza, and Frithiof, Robert

Subjects
*PERIPHERALLY inserted central catheters, *VEINS, *CENTRAL venous catheterization
Abstract

Background: We have developed a new approach for peripherally inserted central catheter (PICC) insertion that we think has several advantages, including ease of insertion, access to a larger vein and patient comfort. Methods: In this case series report, the first 19 cases were audited. Results: All PICCs were inserted without complications; 17 on the first attempt. Conclusion: We conclude that the novel approach to the axillary vein for PICC insertion is feasible and appears to be safe when performed by an experienced operator. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Randomized cross-over study investigating the tolerability and side effects of an intra-oral air-cooling device compared to ice in healthy volunteers

Author

Blacker, C, Bejhed, Rebecca, Frykholm, Peter, Ljungman, Gustaf, Blacker, C, Bejhed, Rebecca, Frykholm, Peter, and Ljungman, Gustaf

Abstract

Oral cryotherapy (OC) is a common preventive treatment of oral mucositis (OM) and is recommended in international guidelines. Ice and air OC have previously been shown to result in temperature reductions of 8.1-12.9 degrees C, and 14.5 degrees C, respectively, in healthy volunteers. However, no direct comparison between these two modalities has been performed. The primary aim was to investigate the tolerability and side effects of air OC using an intra-oral air-cooling (IOAC) device compared with ice OC. The secondary aim was to evaluate the temperature reduction in the mouth for the two respective methods. Cross-over study with randomization to order of treatment, in 15 healthy volunteers. We evaluated the self-reported intensity, frequency, and discomfort for 13 pre-defined side effects used in previous studies. All participants were able to complete both OC sessions, although one participant required reduced airflow in the air OC arm. The subjects reported more discomfort from being cold, having sensitive teeth, and numbness in the ice OC group, while they reported more discomfort from swallowing when subjected to air OC. No significant difference in the median temperature reduction was detected in the two modalities, except for the dorsal posterior part of the tongue where temperature reduction was larger in the ice OC group. We found that oral cooling using a new IOAC device was tolerated and seems to be safe in healthy volunteers.

Published
2023
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28. Ephedrine to treat intraoperative hypotension in infants : what is the target?

Author

de Graaff, Jurgen C., Frykholm, Peter, de Graaff, Jurgen C., and Frykholm, Peter

Abstract

Off-label use of medications in paediatric anaesthesia is common practice, owing to the relative paucity of evidence -based dosing regimens in children. Well-performed dose-finding studies, especially in infants, are rare and urgently needed. Unanticipated effects can result when paediatric dosing is based on adult parameters or local traditions. A recent dose-finding study on ephedrine highlights the uniqueness of paediatric dosing in comparison with adult dosing. We discuss the problems of off-label medication use and the lack of evidence for various definitions of hypotension and associated treatment strategies in paediatric anaesthesia. What is the aim of treating hypotension associated with anaesthesia induction: restoring the MAP to awake baseline values or elevating it above a provisional hypotension threshold?

Published
2023
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32. Neonates undergoing pyloric stenosis repair are at increased risk of difficult airway management: secondary analysis of the NEonate and Children audiT of Anaesthesia pRactice IN Europe

Author

Disma, Nicola, primary, Engelhardt, Thomas, additional, Hansen, Tom G., additional, de Graaff, Jurgen C., additional, Virag, Katalin, additional, Habre, Walid, additional, Breschan, Christian, additional, Likar, Rudolf, additional, Platzer, Manuela, additional, Edelman, Isole, additional, Eger, Johanes, additional, Heschl, Stefan, additional, Messerer, Brigitte, additional, Vittinghof, Maria, additional, Kroess, Ruth, additional, Stichlberger, Martina, additional, Kahn, David, additional, Pirotte, Thierry, additional, Pregardien, Caroline, additional, Veyckemans, Francis, additional, Stevens, France, additional, Berghmans, Johan, additional, Bauters, Annemie, additional, De Baerdemaeker, Luc, additional, De Hert, Stefan, additional, Lapage, Koen, additional, Parashchanka, Aliaksandra, additional, Van Limmen, Jurgen, additional, Wyffels, Piet, additional, Lauweryns, Julie, additional, Najafi, Nadia, additional, Vundelinckx, Joris, additional, Butković, Diana, additional, Sorić, Ivana Kerovec, additional, Kralik, Sandra, additional, Markić, Ana, additional, Azman, Josip, additional, Markic, Josko, additional, Pupacic, Daniela, additional, Frelich, Michal, additional, Reimer, Petr, additional, Urbanec, René, additional, Cajková, Petra, additional, Mixa, Vladimír, additional, Sedláčková, Yvona, additional, Knoppová, Lenka, additional, Zlámalová (neé Květoňová), Alena, additional, Vavřina, Martin, additional, Žurek, Jiří, additional, Hansen, Tom, additional, Afshari, Arash, additional, Bille, Anders Bastholm, additional, Ellekvist, Marguerite, additional, Ilmoja, Mari-Liis, additional, Moor, Reet, additional, Kikas, Reet, additional, Väli, Merle, additional, Kallio, Kariantti, additional, Reponen, Elisa, additional, Suominen, Pertti, additional, Suvanto, Sami, additional, Vähätalo, Raisa, additional, Kokki, Hannu, additional, Kokki, Merja, additional, Harju, Jarkko, additional, Kokkonen, Miia, additional, Vieri, Jenni, additional, Manner, Tuula, additional, Catherine, Amory, additional, Ludot, Hugues, additional, Bert, Dina, additional, Godart, Juliette, additional, Laffargue, Anne, additional, Dupont, Hervé, additional, Urbina, Benjamin, additional, Baujard, Catherine, additional, Roulleau, Philippe, additional, Staiti, Giuseppe, additional, Bordes, Maryline, additional, Gaulain, Karine Nouette, additional, Hamonic, Yann, additional, Semjen, François, additional, Jacqmarcq, Olivier, additional, Lejus-Bourdeau Cécile Magne, Caroline, additional, Petry, Léa, additional, Ros, Lilica, additional, Zang, Aurélien, additional, Bennis, Mehdi, additional, Coustets, Bernard, additional, Fesseau, Rose, additional, Constant, Isabelle, additional, Khalil, Eliane, additional, Sabourdin, Nada, additional, Audren, Noemie, additional, Descarpentries, Thomas, additional, Fabre, Fanny, additional, Legrand, Aurélien, additional, Druot, Emilie, additional, Orliaguet, Gilles, additional, Sabau, Lucie, additional, Uhrig, Lynn, additional, Brière, François de la, additional, Jonckheer, Karin, additional, Mission, Jean-Paul, additional, Scordo, Lucia, additional, Couchepin, Caroline, additional, Dadure, Christophe, additional, De la Arena, Pablo, additional, Hertz, Laurent, additional, Pirat, Philippe, additional, Sola, Chrystelle, additional, Bellon, Myriam, additional, Dahmani, Souhayl, additional, Julien-Marsollier, Florence, additional, Michelet, Daphne, additional, Depret-Donatien, Veronique, additional, Lesage, Anne, additional, Kaufmann, Jost, additional, Laschat, Michael, additional, Wappler, Frank, additional, Becke, Karin, additional, Brunner, Lena, additional, Oppenrieder, Karin, additional, Badelt, Gregor, additional, Hochmuth, Karin, additional, Koller, Bernhard, additional, Reil, Anita, additional, Richter, Sebastian, additional, Fischer, Thomas, additional, Diers, Anja, additional, Schorer, Clemens, additional, Weyland, Andreas, additional, Cohausz, Ruth, additional, Kretz, Franz-Josef, additional, Löffler, Michaela, additional, Wilbs, Markus, additional, Hoehne, Claudia, additional, Ulrici, Johanna, additional, Goeters, Christiane, additional, Flinspach, Armin, additional, Klages, Matthias, additional, Lindau, Simone, additional, Messroghli, Leila, additional, Zacharowski, Kai, additional, Eisner, Christoph, additional, Mueller, Thomas, additional, Richter, Daniel, additional, Schäfer, Melanie, additional, Weigand, Markus, additional, Weiterer, Sebastian, additional, Ochsenreiter, Miriam, additional, Schöler, Michael, additional, Terboven, Tom, additional, Eggemann, Isabel, additional, Haussmann, Sascha, additional, Leister, Nicolas, additional, Menzel, Christoph, additional, Trieschmann, Uwe, additional, Yücetepe, Sirin, additional, Keilig, Susanna, additional, Kranke, Peter, additional, Jelting, Yvonne, additional, Baehner, Torsten, additional, Ellerkmann, Richard, additional, Ghamari, Shahab, additional, Neumann, Claudia, additional, Söhle, Martin, additional, Chloropoulou, Pelagia, additional, Ntritsou, Vagia, additional, Papagiannopoulou, Pinelopi, additional, Garini, Eleana, additional, Karafotia, Afroditi, additional, Mammi, Panagoula, additional, Bali, Evangelia, additional, Iordanidou, Despoina, additional, Malisiova, Anna, additional, Polyzoi, Artemis, additional, Tsiotou, Adelais, additional, Sapi, Erzsebet, additional, Székely, Edgar, additional, Kosik, Nandor, additional, Maráczi, Veronika, additional, Schnur, Janos, additional, Csillag, Judit, additional, Gál, János, additional, Göbl, Gergely, additional, Hauser, Balázs, additional, Petróczy, András, additional, Tövisházi, Gyula, additional, Blain, Stuart, additional, Gallagher, Sarah, additional, Harte, Sinead, additional, Jackson, Mandy, additional, Meehan, Emma, additional, Nawoor, Zeenat, additional, O’Hare, Brendan, additional, Ross, Mark, additional, Lerro, Daniela, additional, Astuto, Marinella, additional, Grasso, Chiara, additional, Scalisi, Rita, additional, Frasacco, Giulia, additional, Lenares, Elena, additional, Leone, Roberto, additional, Grazzini, Maurizia, additional, Minardi, Carmelo, additional, Zadra, Nicola, additional, Cinnella, Gilda, additional, Cotoia, Antonella, additional, Galante, Dario, additional, De Lorenzo, Brita, additional, Kuppers, Beate, additional, Bottazzi, Giulia, additional, Caramelli, Fabio, additional, Mondardini, Maria Cristina, additional, Rossetti, Emanuele, additional, Picardo, Sergio, additional, Vittori, Alessandro, additional, Camporesi, Anna, additional, Izzo, Francesca, additional, Calderini, Edoardo, additional, Colantonio, Laura Brigitta, additional, Finamore, Simona Anna, additional, Porro, Giuliana Anna, additional, Bonfiglio, Rachele, additional, Disma, Nicola, additional, Kotzeva, Svetlana, additional, Mattioli, Girolamo, additional, Micalizzi, Camilla, additional, Montaguti, Alessia, additional, Pistorio, Angela, additional, Guddo, Anna, additional, Neba, Gerald Rogan, additional, Favarato, Moreno, additional, Locatelli, Bruno Guido, additional, Maffioletti, Micol, additional, Sonzogni, Valter, additional, Garra, Rossella, additional, Sammartino, Maria, additional, Sbaraglia, Fabio, additional, Cortegiani, Andrea, additional, Moscarelli, Alessandra, additional, Attanasi, Elena, additional, Tesoro, Simonetta, additional, Agapiti, Cristina, additional, Pinzoni, Francesca, additional, Vezzoli, Cesare, additional, Federico, Bilotta, additional, Barzdina, Arta, additional, Straume, Zane, additional, Zundane, Anda, additional, Lukosiene, Laura, additional, Maraulaite, Irena, additional, Razlevice, Ilona, additional, Schmitz, Bernd, additional, Mifsud, Stephanie, additional, Aehling, Carolin, additional, Allison, Celia, additional, De Boer, Rients, additional, Emal, Dina, additional, Stevens, Markus, additional, Buitenhuis, Marielle, additional, de Graaff, Jurgen, additional, De Liefde, Inge, additional, Machotta, Andreas, additional, Scoones, Gail, additional, Staals, Lonneke, additional, Tomas, Jeremy, additional, Van der Knijff-van Dortmont, Anouk, additional, Veldhuizen, Marianne, additional, Alders, David, additional, Schafrat, Eva, additional, Schreiber, Jan, additional, Vermeulen, Petronella Mari, additional, Hendriks, Mark, additional, Lako, Sandra, additional, Voet-Lindner, Marieke, additional, Pieters, Barbe, additional, Scheffer, Gert-Jan, additional, Tielens, Luc, additional, Absalom, Anthony R., additional, Bergsma, Margot, additional, De Ruiter, Joke, additional, Meier, Sascha, additional, Volkers, Martin, additional, Zweers, Tjerk, additional, Beukers, Anne M., additional, Boer, Christa, additional, Dertinger, Jurgen, additional, Numan, Sandra, additional, Van Zaane, Bas, additional, Boerke, Wenche B., additional, Ekiz, Nil, additional, Stensrud, Kristoffer, additional, Drage, Inger Marie, additional, Isern, Erik Ramon, additional, Bartkowska-Sniatkowska, Alicja, additional, Grzeskowiak, Malgorzata, additional, Juzwa-Sobieraj, Magdalena, additional, Rosada-Kurasińska, Jowita, additional, Baranowski, Artur, additional, Jakubowska, Karina, additional, Lewandowska, Dorota, additional, Mierzewska-Schmidt, Magdalena, additional, Sawicki, Piotr, additional, Urban-Lechowicz, Magdalena, additional, Przemyslaw, Pomianek, additional, Zielinska, Marzena, additional, Leal, Teresa, additional, Soares, Maria, additional, Pina, Pedro, additional, Pinho, Sílvia, additional, Patuleia, Maria Domingas, additional, Esteves, Catarina Cruz, additional, Salgado, Helena, additional, Santos, Maria João, additional, Badeti, Rodica, additional, Cindea, Iulia, additional, Oana, Loredana, additional, Gurita, Adriana, additional, Ilie, Luminita, additional, Mocioiu, Gabriel, additional, Tabacaru, Radu, additional, Trante, Irina, additional, Munteanu, Valentin, additional, Morariu, Mihai, additional, Nyíri, Emese, additional, Budic, Ivana, additional, Marjanovic, Vesna, additional, Drašković, Biljana, additional, Pandurov, Marina, additional, Ilic, Jordanka, additional, Mandras, Ana, additional, Rados, Zdenka, additional, Stankovic, Nikola, additional, Suica, Maja, additional, Vasiljevic, Sladjana, additional, Knezevic, Mirjana, additional, Milojevic, Irina, additional, Petrov, Ivana, additional, Racic, Selena Puric, additional, Simic, Dusica, additional, Simic, Irena, additional, Stevic, Marija, additional, Vulicevic, Irena, additional, Bystrica, Banská, additional, Cabanová, Barbora, additional, Hanula, Miloslav, additional, Berger, Jelena, additional, Janjatovic, Darja, additional, Štupnik, Špela Pirtovšek, additional, Méndez, Dolores, additional, Pino, Gema, additional, Rubio, Paloma, additional, Izquierdo, Alberto, additional, López, Silvia, additional, Serrano, Cristina González, additional, Cebrián, Jesús, additional, Peleteiro, Ana, additional, Del Rey de Diego, Pilar, additional, García, Ernesto Martínez, additional, Tormo de las Heras, Carolina, additional, Montero, Pablo Troncoso, additional, Arbona, Celia, additional, Artés, David, additional, Chamizo, Alicia, additional, Serrano, Silvia, additional, Comas, Montserrat Suarez, additional, Escribá, Francisco, additional, Auli, Cristina, additional, Pardo, Osvaldo Pérez, additional, Biddle, Natalia Sierra, additional, Castaño, Ceferina Suárez, additional, Villalobos Rico, María Isabel, additional, Muñoz, Susana Manrique, additional, Martínez, Irene García, additional, Estruch, Nuria Montferrer, additional, Ortíz, Elena Vilardell, additional, Poves-Álvarez, Rodrigo, additional, Kohn, Ivan, additional, Lindestam, Ulf, additional, Reinhard, Jarl, additional, Castellheim, Albert, additional, Sandström, Kerstin, additional, Bengt, Sporre, additional, Dörenberg, Rainer, additional, Frykholm, Peter, additional, Garcia, Maria, additional, Kvarnström, Ann, additional, Pontén, Emma, additional, Bruelisauer, Thomas, additional, Erdoes, Gabor, additional, Kaiser, Heiko, additional, Marchon, Mathias, additional, Riva, Thomas, additional, Seiler, Stefan, additional, Bögli, Yann, additional, Dolci, Mirko, additional, Marcucci, Carine, additional, Pichon, Isabelle, additional, Vutskits, Laszlo, additional, Casutt, Mattias, additional, Hölzle, Martin, additional, Hurni, Thomas, additional, Jöhr, Martin, additional, Malär, Anna-Ursina, additional, Mauch, Jacqueline, additional, Erb, Thomas, additional, Oeinck, Karin, additional, Akin, Mine, additional, Keskin, Gulsen, additional, Senayli, Yesim, additional, Kaya, Guner, additional, Kendigelen, Pinar, additional, Tutuncu, Ayse Çiğdem, additional, Hatipoğlu, Zehra, additional, Özcengiz, Dilek, additional, Erdost, Hale Aksu, additional, Öçmen, Elvan, additional, Olguner, Çimen, additional, Ayanoglu, Hilmi, additional, Dincer, Pelin Corman, additional, Umuroglu, Tumay, additional, Azizoglu, Mustafa, additional, Birbiçer, Handan, additional, Doruk, Nurcan, additional, Sagun, Aslı, additional, Baris, Sibel, additional, Dmytriiev, Dmytro, additional, Kuchi, Sridevi, additional, Masip, Nuria, additional, Brooks, Peter, additional, Hare, Alison, additional, Ahmad, Nargis, additional, Casey, Michelle, additional, De Silva, Sam, additional, Dobby, Nadine, additional, Krishnan, Prakash, additional, Sogbodjor, L. Amaki, additional, Walker, Ellie, additional, Walker, Suellen, additional, King, Stephanie, additional, Nicholson, Katy, additional, Quinney, Michelle, additional, Stevens, Paul, additional, Blevin, Andrew, additional, Giombini, Mariangela, additional, Goonasekera, Chulananda, additional, Adil, Sadia, additional, Bew, Stephanie, additional, Bodlani, Carol, additional, Gilpin, Dan, additional, Jinks, Stephanie, additional, Malarkkan, Nalini, additional, Miskovic, Alice, additional, Pad, Rebecca, additional, Barry, Juliet Wolfe, additional, Abbott, Joy, additional, Armstrong, James, additional, Cooper, Natalie, additional, Crate, Lindsay, additional, Emery, John, additional, James, Kathryn, additional, King, Hannah, additional, Martin, Paul, additional, Catenacci, Stefano Scalia, additional, Bomont, Rob, additional, Smith, Paul, additional, Mele, Sara, additional, Verzelloni, Alessandra, additional, Dix, Philippa, additional, Bell, Graham, additional, Gordeva, Elena, additional, McKee, Lesley, additional, Ngan, Esther, additional, Scheffczik, Jutta, additional, Tan, Li-En, additional, Worrall, Mark, additional, Cassar, Carmel, additional, Goddard, Kevin, additional, Barlow, Victoria, additional, Oshan, Vimmi, additional, Shah, Khairi, additional, Bell, Sarah, additional, Daniels, Lisa, additional, Gandhi, Monica, additional, Pachter, David, additional, Perry, Chris, additional, Robertson, Andrew, additional, Scott, Carmen, additional, Waring, Lynne, additional, Barnes, David, additional, Childs, Sophie, additional, Norman, Joanne, additional, Sunderland, Robin, additional, Julia, Dowell, additional, Prisca, Feijten, additional, Pierre, Harlet, additional, Sarah, Herbineaux, additional, Brigitte, Leva, additional, Benoît, Plichon, additional, and Katalin, Virág, additional

Published
2022
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34. Harmonising paediatric anaesthesia training in Europe: Proposal of a roadmap

Author

Hansen, Tom G., Vutskits, Laszlo, Disma, Nicola, Becke-Jakob, Karin, Elfgren, Jochen, Frykholm, Peter, Machotta, Andreas, Weiss, Markus, Engelhardt, Thomas, University of Zurich, Hansen, Tom G, and Anesthesiology

Subjects
Europe, Anesthesiology and Pain Medicine, 10036 Medical Clinic, Humans, Anesthesia, 610 Medicine & health, 10220 Clinic for Surgery, 2703 Anesthesiology and Pain Medicine, Child
Published
2022

35. Effect of high-flow nasal oxygen on postoperative oxygenation in obese patients : A randomized controlled trial

Author

Rosén, Jacob, Frykholm, Peter, Fors, Diddi, Rosén, Jacob, Frykholm, Peter, and Fors, Diddi

Abstract

Background and Aim Postoperative hypoxemia is common after general anesthesia in obese patients. We investigated if early application of high-flow nasal oxygen (HFNO) improved postoperative oxygenation in obese patients compared with standard oxygen therapy following general anesthesia for laparoscopic bariatric surgery. Methods This was an open labeled randomized controlled trial conducted at a university hospital in Sweden between October 23, 2018 and February 11, 2020. The study was performed as a substudy within a previously published trial. After ethics committee approval and written informed consent, 40 obese patients (body mass index [BMI] >= 35 kg m(-2)) scheduled for laparoscopic bariatric surgery were randomized to receive oxygen using a standard low-flow nasal cannula (NC group) or HFNO at 40 L min(-1) (HF group) immediately upon arrival to the post-anesthesia care unit. Flow rate (NC group) or FiO(2) (HF group) was titrated to reach an initial SpO(2) of 95%-98% after which settings were left unchanged. The primary outcome was PaO2 at 60 min following postoperative baseline values. Secondary outcomes included PaCO2, SpO(2), hemodynamic variables, and patient self-assessed discomfort. Results Thirty-four patients were available for analysis. PaO2 was similar between groups at postoperative baseline. After 60 min, PaO2 had increased to 12.6 +/- 2.8 kPa in the NC group (n = 15) and 14.0 +/- 2.7 kPa in the HF group (n = 19); (mean difference 1.4 kPa, 95% confidence interval -0.6 to 3.3; p = 0.16). There were no differences in PaCO2, hemodynamic variables, or self-assessed discomfort between groups after 60 min. Conclusion In obese patients, HFNO did not improve postoperative short-term oxygenation compared with standard low-flow oxygen following general anesthesia for laparoscopic bariatric surgery.

Published
2022
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36. Pre-operative fasting in children : A guideline from the European Society of Anaesthesiology and Intensive Care

Author

Frykholm, Peter, Disma, Nicola, Andersson, Hanna, Beck, Christiane, Bouvet, Lionel, Cercueil, Eloise, Elliott, Elizabeth, Hofmann, Jan, Isserman, Rebecca, Klaucane, Anna, Kuhn, Fabian, de Queiroz Siqueira, Mathilde, Rosen, David, Rudolph, Diana, Schmidt, Alexander R., Schmitz, Achim, Stocki, Daniel, Sümpelmann, Robert, Stricker, Paul A., Thomas, Mark, Veyckemans, Francis, Afshari, Arash, Frykholm, Peter, Disma, Nicola, Andersson, Hanna, Beck, Christiane, Bouvet, Lionel, Cercueil, Eloise, Elliott, Elizabeth, Hofmann, Jan, Isserman, Rebecca, Klaucane, Anna, Kuhn, Fabian, de Queiroz Siqueira, Mathilde, Rosen, David, Rudolph, Diana, Schmidt, Alexander R., Schmitz, Achim, Stocki, Daniel, Sümpelmann, Robert, Stricker, Paul A., Thomas, Mark, Veyckemans, Francis, and Afshari, Arash

Abstract

Current paediatric anaesthetic fasting guidelines have recommended conservative fasting regimes for many years and have not altered much in the last decades. Recent publications have employed more liberal fasting regimes with no evidence of increased aspiration or regurgitation rates. In this first solely paediatric European Society of Anaesthesiology and Intensive Care (ESAIC) pre-operative fasting guideline, we aim to present aggregated and evidence-based summary recommendations to assist clinicians, healthcare providers, patients and parents. We identified six main topics for the literature search: studies comparing liberal with conservative regimens; impact of food composition; impact of comorbidity; the use of gastric ultrasound as a clinical tool; validation of gastric ultrasound for gastric content and gastric emptying studies; and early postoperative feeding. The literature search was performed by a professional librarian in collaboration with the ESAIC task force. Recommendations for reducing clear fluid fasting to 1 h, reducing breast milk fasting to 3 h, and allowing early postoperative feeding were the main results, with GRADE 1C or 1B evidence. The available evidence suggests that gastric ultrasound may be useful for clinical decision-making, and that allowing a ‘light breakfast’ may be well tolerated if the intake is well controlled. More research is needed in these areas as well as evaluation of how specific patient or treatment-related factors influence gastric emptying.

Published
2022
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38. Perioperative fasting times in children and adolescents

Author

Suempelmann, R., Beck, C., Rudolph, D., Becke-Jakob, K., Eich, C., Engelhardt, T., Frykholm, Peter, Joehr, M., Oppitz, F., Roeher, K., Rueggeberg, A., Russo, S., Schindler, E., Schmitz, A., Ziegler, Bernhard, Suempelmann, R., Beck, C., Rudolph, D., Becke-Jakob, K., Eich, C., Engelhardt, T., Frykholm, Peter, Joehr, M., Oppitz, F., Roeher, K., Rueggeberg, A., Russo, S., Schindler, E., Schmitz, A., and Ziegler, Bernhard

Abstract

The German Scientific Working Group for Paediatric Anaesthesia (Wissenschaftlicher Arbeitskreis Kinderansthesie, WAKKA) of the German Society for Anaesthesia and Intensive Care Medicine (DGAI) has updated their current recommendations on preoperative fasting in children from 2007, along with the preoperative fasting statement of the German Association of Anaesthesiologists (Berufsverband Deutscher Anasthesisten, BDA) and DGAI from 2016 in agreement with the new evidence-based European Guideline of the European Society of Anaesthesiology and Intensive Care (ESAIC) of 2022 - and transferred it into the S1 Guideline format of the Association of the Scientific. Medical Societies in Germany (Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgeselischaften e. V., AWMF). This revision became necessary because recent studies had shown that optimized fasting times improved hornoeostasis and well-being of the children, while the risk of regurgitation and aspiration had not increased. On the other hand, long periods of fasting might be the cause of misbehaviour, stress, iatrogenic dehydration and catabolism. The updated S1 Guideline therefore recommends shorter fasting times of 4 hours for small, light meals and/or formula or cow's milk (still 6 hours for a full meal), 3 hours for breast milk, and 1 hour for clear fluids (6-4-3-1 Rule). In addition, the new S1 Guideline contains further recommendations for children with concomitant diseases that are of relevance to anaesthesia, for the application of ultrasound to examine the stomach content prior to the induction of anaesthesia, for postoperative fasting and the implementation of the new rules in clinical practice.

Published
2022
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40. Pre-operative fasting in children:A guideline from the European Society of Anaesthesiology and Intensive Care

Author

Frykholm, Peter, Disma, Nicola, Andersson, Hanna, Beck, Christiane, Bouvet, Lionel, Cercueil, Eloise, Elliott, Elizabeth, Hofmann, Jan, Isserman, Rebecca, Klaucane, Anna, Kuhn, Fabian, de Queiroz Siqueira, Mathilde, Rosen, David, Rudolph, Diana, Schmidt, Alexander R., Schmitz, Achim, Stocki, Daniel, Sümpelmann, Robert, Stricker, Paul A., Thomas, Mark, Veyckemans, Francis, Afshari, Arash, Frykholm, Peter, Disma, Nicola, Andersson, Hanna, Beck, Christiane, Bouvet, Lionel, Cercueil, Eloise, Elliott, Elizabeth, Hofmann, Jan, Isserman, Rebecca, Klaucane, Anna, Kuhn, Fabian, de Queiroz Siqueira, Mathilde, Rosen, David, Rudolph, Diana, Schmidt, Alexander R., Schmitz, Achim, Stocki, Daniel, Sümpelmann, Robert, Stricker, Paul A., Thomas, Mark, Veyckemans, Francis, and Afshari, Arash

Abstract

Current paediatric anaesthetic fasting guidelines have recommended conservative fasting regimes for many years and have not altered much in the last decades. Recent publications have employed more liberal fasting regimes with no evidence of increased aspiration or regurgitation rates. In this first solely paediatric European Society of Anaesthesiology and Intensive Care (ESAIC) pre-operative fasting guideline, we aim to present aggregated and evidence-based summary recommendations to assist clinicians, healthcare providers, patients and parents. We identified six main topics for the literature search: studies comparing liberal with conservative regimens; impact of food composition; impact of comorbidity; the use of gastric ultrasound as a clinical tool; validation of gastric ultrasound for gastric content and gastric emptying studies; and early postoperative feeding. The literature search was performed by a professional librarian in collaboration with the ESAIC task force. Recommendations for reducing clear fluid fasting to 1 h, reducing breast milk fasting to 3 h, and allowing early postoperative feeding were the main results, with GRADE 1C or 1B evidence. The available evidence suggests that gastric ultrasound may be useful for clinical decision-making, and that allowing a 'light breakfast' may be well tolerated if the intake is well controlled. More research is needed in these areas as well as evaluation of how specific patient or treatment-related factors influence gastric emptying.

Published
2022

42. Harmonising paediatric anaesthesia training in Europe:Proposal of a roadmap

Author

Hansen, Tom G., Vutskits, Laszlo, Disma, Nicola, Becke-Jakob, Karin, Elfgren, Jochen, Frykholm, Peter, Machotta, Andreas, Weiss, Markus, Engelhardt, Thomas, Hansen, Tom G., Vutskits, Laszlo, Disma, Nicola, Becke-Jakob, Karin, Elfgren, Jochen, Frykholm, Peter, Machotta, Andreas, Weiss, Markus, and Engelhardt, Thomas

Published
2022

45. Pre-operative fasting in children

Author

Frykholm, Peter, primary, Disma, Nicola, additional, Andersson, Hanna, additional, Beck, Christiane, additional, Bouvet, Lionel, additional, Cercueil, Eloise, additional, Elliott, Elizabeth, additional, Hofmann, Jan, additional, Isserman, Rebecca, additional, Klaucane, Anna, additional, Kuhn, Fabian, additional, de Queiroz Siqueira, Mathilde, additional, Rosen, David, additional, Rudolph, Diana, additional, Schmidt, Alexander R., additional, Schmitz, Achim, additional, Stocki, Daniel, additional, Sümpelmann, Robert, additional, Stricker, Paul A., additional, Thomas, Mark, additional, Veyckemans, Francis, additional, and Afshari, Arash, additional

Published
2022
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48. Lung recruitment assessed by total respiratory system input reactance

Author

Dellaca, Raffaele L., Andersson Olerud, Marie, Zannin, Emanuela, Kostic, Peter, Pompilio, Pasquale P., Hedenstierna, Goran, Pedotti, Antonio, and Frykholm, Peter

Subjects
Acute respiratory distress syndrome -- Diagnosis, Acute respiratory distress syndrome -- Care and treatment, Lung volume measurements -- Usage, Artificial respiration -- Physiological aspects, Health care industry
Abstract

Byline: Raffaele L. Dellaca (1), Marie Andersson Olerud (2), Emanuela Zannin (1), Peter Kostic (2), Pasquale P. Pompilio (1), Goran Hedenstierna (3), Antonio Pedotti (1), Peter Frykholm (2) Keywords: Forced oscillation technique; ALI/ARDS; Mechanical ventilation; PEEP; Respiratory mechanics Abstract: Purpose ALI and ARDS are associated with lung volume derecruitment, usually counteracted by PEEP and recruitment maneuvers (RM), which should be accurately tailored to the patient's needs. The aim of this study was to investigate the possibility of monitoring the amount of derecruited lung by the forced oscillation technique (FOT). Methods We studied six piglets (26 +- 2.5 kg) ventilated by a mechanical ventilator connected to a FOT device that produced sinusoidal pressure forcing at 5 Hz. The percentage of non-aerated lung tissue (V tiss.sub.NA%) was measured by whole-body CT scans at end-expiration with zero end-expiratory pressure. Respiratory system oscillatory input reactance (X .sub.rs) was measured simultaneously to CT and used to derive oscillatory compliance (C .sub.X5), which we used as an index of recruited lung. Measurements were performed at baseline and after several interventions in the following sequence: mono-lateral reabsorption atelectasis, RM, bi-lateral derecruitment induced by broncho-alveolar lavage and a second RM. Results By pooling data from all experimental conditions and all pigs, C .sub.X5 was linearly correlated to V tiss.sub.NA% (r .sup.2 = 0.89) regardless of the procedure used to de-recruit the lung (reabsorption atelectasis or pulmonary lavage). Separate correlation analysis on single pigs showed similar regression equations, with an even higher coefficient of determination (r .sup.2 = 0.91 +- 0.07). Conclusion These results suggest that FOT and the measurement of C .sub.X5 could be a useful tool for the non-invasive measurement of lung volume recruitment/derecruitment. Author Affiliation: (1) Dipartimento di Bioingegneria, Politecnico di Milano University, Piazza Leonardo da Vinci 32, 20133, Milan, Italy (2) Department of Surgical Sciences, Anaesthesia and Intensive Care, Uppsala University, Uppsala, Sweden (3) Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden Article History: Registration Date: 10/09/2009 Received Date: 19/01/2009 Accepted Date: 02/09/2009 Online Date: 30/09/2009 Article note: Electronic supplementary material The online version of this article (doi: 10.1007/s00134-009-1673-3) contains supplementary material, which is available to authorized users.

Published
2009

49. Role of Renal Sympathetic Nerve Activity in Volatile Anesthesia's Effect on Renal Excretory Function

Author

Taavo, Micael, Rundgren, Mats, Frykholm, Peter, Larsson, Anders, Franzén, Stephanie, Vargmar, Karin, Valarcher, Jean F., DiBona, Gerald F., and Frithiof, Robert

Subjects
surgery, renal failure, kidney, Anestesi och intensivvård, Fysiologi, Anesthesiology and Intensive Care, Physiology, urine output, oliguria, ischemia, anesthesia, urologic and male genital diseases, Acute Kidney Injury (AKI)
Abstract

Regulation of fluid balance is pivotal during surgery and anesthesia and affects patient morbidity, mortality, and hospital length of stay. Retention of sodium and water is known to occur during surgery but the mechanisms are poorly defined. In this study, we explore how the volatile anesthetic sevoflurane influences renal function by affecting renal sympathetic nerve activity (RSNA). Our results demonstrate that sevoflurane induces renal sodium and water retention during pediatric anesthesia in association with elevated plasma concentration of renin but not arginine–vasopressin. The mechanisms are further explored in conscious and anesthetized ewes where we show that RSNA is increased by sevoflurane compared with when conscious. This is accompanied by renal sodium and water retention and decreased renal blood flow (RBF). Finally, we demonstrate that renal denervation normalizes renal excretory function and improves RBF during sevoflurane anesthesia in sheep. Taken together, this study describes a novel role of the renal sympathetic nerves in regulating renal function and blood flow during sevoflurane anesthesia.

Published
2021

50. Additional file 1 of Awake prone positioning in patients with hypoxemic respiratory failure due to COVID-19: the PROFLO multicenter randomized clinical trial

Author

Rosén, Jacob, von Oelreich, Erik, Fors, Diddi, Jonsson Fagerlund, Malin, Taxbro, Knut, Skorup, Paul, Eby, Ludvig, Campoccia Jalde, Francesca, Johansson, Niclas, Bergström, Gustav, and Frykholm, Peter

Subjects
respiratory tract diseases
Abstract

Additional file 1. Supplementary information. eTable 1. Inclusion criteria based on SpO2 at various FiO2-values approximating a PaO2/FiO2 ratio of 20 kPa (150 mmHg). eTable 2. Interim analysis criteria for early trial termination. eFigure 1. Trial protocol flow-chart. eFigure 2a-c. Trial definitions of prone and semi-prone position. eFigure 3. Results of the exploratory analysis of patients with shorter (n = 26) than 3 h or longer (n = 26) than 9 h duration of awake prone positioning irrespective of group allocation presented as Kaplan-Meier graphs. eFigure 4. Results of the exploratory analysis of patients in the control group (n = 13) and prone group (n = 14) with PaO2/FiO2 ratio ≤ 15 kPa presented as Kaplan-Meier graphs.

Published
2021
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