88,253 results on '"Fry A"'
Search Results
2. Intravenous thrombolysis in acute ischaemic stroke two years into the COVID-19 pandemic: A retrospective study
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Jala, Sheila, Bertmar, Carin, Fry, Margaret, Elliott, Rosalind, Day, Susan, O’Brien, Elizabeth, Priglinger-Coorey, Miriam, and Krause, Martin
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- 2024
3. The Isotope Effect in the Decomposition of Oxalic Acid 1,2
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Fry, Arthur and Calvin, Melvin
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- 2024
4. Heavy tails and negative correlation in a binomial model for sports matches: applications to curling
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Fry, John, Austin, Mark, and Fanzon, Silvio
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Statistics - Applications ,Mathematics - Probability ,62P25, 91-10, 62M99 - Abstract
A binomial model for sports matches is developed making use of the maximum possible score $n$ in a game. In contrast to previous approaches the scores of the two teams are negatively correlated, abstracting from a scenario whereby teams cancel each other out. When $n$ is known, analytical results are possible via a Gaussian approximation. Model calibration is obtained via generalized linear modelling, enabling elementary econometric and strategic analysis to be performed. Inter alia this includes quantifying the Last Stone First End effect, analogous to the home-field advantage found in conventional sports. When $n$ is unknown the model behaviour is richer and leads to heavy-tailed non-Gaussian behaviour. We present an approximate analysis of this case based on the Variance Gamma distribution.
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- 2024
5. A normal version of Brauer's height zero conjecture
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Moretó, Alexander and Fry, A. A. Schaeffer
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Mathematics - Group Theory - Abstract
The celebrated It\^o-Michler theorem asserts that a prime $p$ does not divide the degree of any irreducible character of a finite group $G$ if and only if $G$ has a normal and abelian Sylow $p$-subgroup. The principal block case of the recently-proven Brauer's height zero conjecture isolates the abelian part in the It\^o-Michler theorem. In this paper, we show that the normal part can also be isolated in a similar way. This is a consequence of work on a strong form of the so-called Brauer's height zero conjecture for two primes of Malle and Navarro. Using our techniques, we also provide an alternate proof of this conjecture., Comment: Revised following Gunter Malle's suggestions
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- 2024
6. Schwarz preconditioner with $H_k$-GenEO coarse space for the indefinite Helmholtz problem
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Dolean, Victorita, Fry, Mark, Graham, Ivan G., and Langer, Matthias
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Mathematics - Numerical Analysis ,65N22, 65N55, 65F10 - Abstract
GenEO (`Generalised Eigenvalue problems on the Overlap') is a method from the family of spectral coarse spaces that can efficiently rely on local eigensolves in order to build a robust parallel domain decomposition preconditioner for elliptic PDEs. When used as a preconditioner in a conjugate gradient, this method is extremely efficient in the positive-definite case, yielding an iteration count completely independent of the number of subdomains and heterogeneity. In a previous work this theory was extended to the cased of convection--diffusion--reaction problems, which may be non-self-adjoint and indefinite, and whose discretisations are solved with preconditioned GMRES. The GenEO coarse space was then defined here using a generalised eigenvalue problem based on a self-adjoint and positive definite subproblem. The resulting method, called $\Delta$-GenEO becomes robust with respect to the variation of the coefficient of the diffusion term in the operator and depends only very mildly on variations of the other coefficients. However, the iteration number estimates get worse as the non-self-adjointness and indefiniteness of the operator increases, which is often the case for the high frequency Helmholtz problems. In this work, we will improve on this aspect by introducing a new version, called $H_k$-GenEO, which uses a generalised eigenvalue problem based directly on the indefinite operator which will lead to a robust method with respect to the increase in the wave-number. We provide theoretical estimates showing the dependence of the size of the coarse space on the wave-number., Comment: arXiv admin note: text overlap with arXiv:2403.18378
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- 2024
7. TIDMAD: Time Series Dataset for Discovering Dark Matter with AI Denoising
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Fry, J. T., Li, Aobo, Winslow, Lindley, Fu, Xinyi Hope, Fu, Zhenghao, and Pappas, Kaliroe M. W.
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Computer Science - Machine Learning ,High Energy Physics - Experiment - Abstract
Dark matter makes up approximately 85% of total matter in our universe, yet it has never been directly observed in any laboratory on Earth. The origin of dark matter is one of the most important questions in contemporary physics, and a convincing detection of dark matter would be a Nobel-Prize-level breakthrough in fundamental science. The ABRACADABRA experiment was specifically designed to search for dark matter. Although it has not yet made a discovery, ABRACADABRA has produced several dark matter search results widely endorsed by the physics community. The experiment generates ultra-long time-series data at a rate of 10 million samples per second, where the dark matter signal would manifest itself as a sinusoidal oscillation mode within the ultra-long time series. In this paper, we present the TIDMAD -- a comprehensive data release from the ABRACADABRA experiment including three key components: an ultra-long time series dataset divided into training, validation, and science subsets; a carefully-designed denoising score for direct model benchmarking; and a complete analysis framework which produces a community-standard dark matter search result suitable for publication as a physics paper. This data release enables core AI algorithms to extract the signal and produce real physics results thereby advancing fundamental science. The data downloading and associated analysis scripts are available at https://github.com/jessicafry/TIDMAD
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- 2024
8. Characters and Sylow $3$-subgroup abelianization
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Giannelli, Eugenio, Rizo, Noelia, Fry, A. A. Schaeffer, and Vallejo, Carolina
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Mathematics - Group Theory ,Mathematics - Representation Theory - Abstract
We characterize when a finite group G possesses a Sylow 3-subgroup P with abelianization of order 9 in terms of the number of height zero characters lying in the principal 3-block of G, settling a conjecture put forward by Navarro, Sambale, and Tiep in 2018. Along the way, we show that a recent result by Laradji on the number of character of height zero in a block that lie above a given character of some normal subgroup holds, without any hypothesis on the group for blocks of maximal defect., Comment: slight title change and other minor changes, following helpful comments thanks to Gunter Malle and Bejamin Sambale
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- 2024
9. The sounds of science a symphony for many instruments and voices part II
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Hooft, Gerard t, Phillips, William D, Zeilinger, Anton, Allen, Roland, Baggott, Jim, Bouchet, Francois R, Cantanhede, Solange M G, Castanedo, Lazaro A M, Cetto, Ana Maria, Coley, Alan A, Dalton, Bryan J, Fahimi, Peyman, Franks, Sharon, Frano, Alex, Fry, Edward S, Goldfarb, Steven, Langanke, Karlheinz, Matta, Cherif F, Nanopoulos, Dimitri, Orzel, Chad, Patrick, Sam, Sanghai, Viraj A A, Schuller, Ivan K, Shpyrko, Oleg, and Lidstrom, Suzy
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Physics - Physics and Society - Abstract
Despite its amazing quantitative successes and contributions to revolutionary technologies, physics currently faces many unsolved mysteries ranging from the meaning of quantum mechanics to the nature of the dark energy that will determine the future of the Universe. It is clearly prohibitive for the general reader, and even the best informed physicists, to follow the vast number of technical papers published in the thousands of specialized journals. For this reason, we have asked the leading experts across many of the most important areas of physics to summarise their global assessment of some of the most important issues. In lieu of an extremely long abstract summarising the contents, we invite the reader to look at the section headings and their authors, and then to indulge in a feast of stimulating topics spanning the current frontiers of fundamental physics from The Future of Physics by William D Phillips and What characterises topological effects in physics? by Gerard t Hooft through the contributions of the widest imaginable range of world leaders in their respective areas. This paper is presented as a preface to exciting developments by senior and young scientists in the years that lie ahead, and a complement to the less authoritative popular accounts by journalists., Comment: 54 pages, 13 figures
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- 2024
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10. Development and Validation of a Novel Placental DNA Methylation Biomarker of Maternal Smoking during Pregnancy in the ECHO Program.
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Shorey-Kendrick, Lyndsey, Davis, Brett, Gao, Lina, Park, Byung, Vu, Annette, Morris, Cynthia, Breton, Carrie, Fry, Rebecca, Garcia, Erika, Schmidt, Rebecca, OShea, T, Tepper, Robert, McEvoy, Cindy, and Spindel, Eliot
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Humans ,Female ,Pregnancy ,DNA Methylation ,Placenta ,Biomarkers ,Adult ,Double-Blind Method ,Machine Learning - Abstract
BACKGROUND: Maternal cigarette smoking during pregnancy (MSDP) is associated with numerous adverse health outcomes in infants and children with potential lifelong consequences. Negative effects of MSDP on placental DNA methylation (DNAm), placental structure, and function are well established. OBJECTIVE: Our aim was to develop biomarkers of MSDP using DNAm measured in placentas (N=96), collected as part of the Vitamin C to Decrease the Effects of Smoking in Pregnancy on Infant Lung Function double-blind, placebo-controlled randomized clinical trial conducted between 2012 and 2016. We also aimed to develop a digital polymerase chain reaction (PCR) assay for the top ranking cytosine-guanine dinucleotide (CpG) so that large numbers of samples can be screened for exposure at low cost. METHODS: We compared the ability of four machine learning methods [logistic least absolute shrinkage and selection operator (LASSO) regression, logistic elastic net regression, random forest, and gradient boosting machine] to classify MSDP based on placental DNAm signatures. We developed separate models using the complete EPIC array dataset and on the subset of probes also found on the 450K array so that models exist for both platforms. For comparison, we developed a model using CpGs previously associated with MSDP in placenta. For each final model, we used model coefficients and normalized beta values to calculate placental smoking index (PSI) scores for each sample. Final models were validated in two external datasets: the Extremely Low Gestational Age Newborn observational study, N=426; and the Rhode Island Childrens Health Study, N=237. RESULTS: Logistic LASSO regression demonstrated the highest performance in cross-validation testing with the lowest number of input CpGs. Accuracy was greatest in external datasets when using models developed for the same platform. PSI scores in smokers only (n=72) were moderately correlated with maternal plasma cotinine levels. One CpG (cg27402634), with the largest coefficient in two models, was measured accurately by digital PCR compared with measurement by EPIC array (R2=0.98). DISCUSSION: To our knowledge, we have developed the first placental DNAm-based biomarkers of MSDP with broad utility to studies of prenatal disease origins. https://doi.org/10.1289/EHP13838.
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- 2024
11. Network model of skeletal muscle cell signalling predicts differential responses to endurance and resistance exercise training.
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Fowler, Annabelle, Knaus, Katherine, Khuu, Stephanie, Khalilimeybodi, Ali, Schenk, Simon, Ward, Samuel, Fry, Andrew, Rangamani, Padmini, and McCulloch, Andrew
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computational model ,endurance exercise ,exercise ,resistance exercise ,signalling network ,skeletal muscle ,Humans ,Signal Transduction ,Muscle ,Skeletal ,Resistance Training ,Physical Endurance ,Animals ,Adaptation ,Physiological ,Exercise ,Models ,Biological - Abstract
Exercise-induced muscle adaptations vary based on exercise modality and intensity. We constructed a signalling network model from 87 published studies of human or rodent skeletal muscle cell responses to endurance or resistance exercise in vivo or simulated exercise in vitro. The network comprises 259 signalling interactions between 120 nodes, representing eight membrane receptors and eight canonical signalling pathways regulating 14 transcriptional regulators, 28 target genes and 12 exercise-induced phenotypes. Using this network, we formulated a logic-based ordinary differential equation model predicting time-dependent molecular and phenotypic alterations following acute endurance and resistance exercises. Compared with nine independent studies, the model accurately predicted 18/21 (85%) acute responses to resistance exercise and 12/16 (75%) acute responses to endurance exercise. Detailed sensitivity analysis of differential phenotypic responses to resistance and endurance training showed that, in the model, exercise regulates cell growth and protein synthesis primarily by signalling via mechanistic target of rapamycin, which is activated by Akt and inhibited in endurance exercise by AMP-activated protein kinase. Endurance exercise preferentially activates inflammation via reactive oxygen species and nuclear factor κB signalling. Furthermore, the expected preferential activation of mitochondrial biogenesis by endurance exercise was counterbalanced in the model by protein kinase C in response to resistance training. This model provides a new tool for investigating cross-talk between skeletal muscle signalling pathways activated by endurance and resistance exercise, and the mechanisms of interactions such as the interference effects of endurance training on resistance exercise outcomes.
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- 2024
12. Cross-Sectional Associations between Prenatal Per- and Poly-Fluoroalkyl Substances and Bioactive Lipids in Three Environmental Influences on Child Health Outcomes (ECHO) Cohorts
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Suthar, Himal, Manea, Tomás, Pak, Dominic, Woodbury, Megan, Eick, Stephanie M, Cathey, Amber, Watkins, Deborah J, Strakovsky, Rita S, Ryva, Brad A, Pennathur, Subramaniam, Zeng, Lixia, Weller, David, Park, June-Soo, Smith, Sabrina, DeMicco, Erin, Padula, Amy, Fry, Rebecca C, Mukherjee, Bhramar, Aguiar, Andrea, Geiger, Sarah Dee, Ng, Shukhan, Huerta-Montanez, Gredia, Vélez-Vega, Carmen, Rosario, Zaira, Cordero, Jose F, Zimmerman, Emily, Woodruff, Tracey J, Morello-Frosch, Rachel, Schantz, Susan L, Meeker, John D, Alshawabkeh, Akram N, Aung, Max T, and Outcomes, on behalf of Program Collaborators for Environmental Influences on Child Health
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Biomedical and Clinical Sciences ,Public Health ,Health Sciences ,Women's Health ,Pediatric ,Endocrine Disruptors ,Clinical Research ,Prevention ,Pregnancy ,Conditions Affecting the Embryonic and Fetal Periods ,2.1 Biological and endogenous factors ,Aetiology ,Reproductive health and childbirth ,Good Health and Well Being ,Humans ,Female ,Lipids ,Fluorocarbons ,Child Health ,Cohort Studies ,Cross-Sectional Studies ,Adult ,Environmental Pollutants ,Environmental Exposure ,Maternal Exposure ,Child ,PFAS ,mixtures ,bioactive lipids ,eicosanoids ,pregnancy outcomes ,inflammatory pathways ,metabolic pathways ,Program Collaborators for Environmental Influences on Child Health Outcomes ,Environmental Sciences - Abstract
Prenatal per- and poly-fluoroalkyl substances (PFAS) exposure may influence gestational outcomes through bioactive lipids─metabolic and inflammation pathway indicators. We estimated associations between prenatal PFAS exposure and bioactive lipids, measuring 12 serum PFAS and 50 plasma bioactive lipids in 414 pregnant women (median 17.4 weeks' gestation) from three Environmental influences on Child Health Outcomes Program cohorts. Pairwise association estimates across cohorts were obtained through linear mixed models and meta-analysis, adjusting the former for false discovery rates. Associations between the PFAS mixture and bioactive lipids were estimated using quantile g-computation. Pairwise analyses revealed bioactive lipid levels associated with PFDeA, PFNA, PFOA, and PFUdA (p < 0.05) across three enzymatic pathways (cyclooxygenase, cytochrome p450, lipoxygenase) in at least one combined cohort analysis, and PFOA and PFUdA (q < 0.2) in one linear mixed model. The strongest signature revealed doubling in PFOA corresponding with PGD2 (cyclooxygenase pathway; +24.3%, 95% CI: 7.3-43.9%) in the combined cohort. Mixture analysis revealed nine positive associations across all pathways with the PFAS mixture, the strongest signature indicating a quartile increase in the PFAS mixture associated with PGD2 (+34%, 95% CI: 8-66%), primarily driven by PFOS. Bioactive lipids emerged as prenatal PFAS exposure biomarkers, deepening insights into PFAS' influence on pregnancy outcomes.
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- 2024
13. Improvements to the theoretical estimates of the Schwarz preconditioner with $\Delta$-GenEO coarse space for the indefinite Helmholtz problem
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Dolean, Victorita, Fry, Mark, and Langer, Matthias
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Mathematics - Numerical Analysis ,65N22, 65N55, 65F10 - Abstract
The purpose of this work is to improve the estimates for the $\Delta$-GenEO method from the paper "Overlapping Schwarz methods with GenEO coarse spaces for indefinite and nonself-adjoint problems" by N. Bootland, V. Dolean, I. G Graham, C. Ma, R. Scheichl (https://doi.org/10.1093/imanum/drac036) when applied to the indefinite Helmholtz equation. We derive k-dependent estimates of quantities of interest ensuring the robustness of the method.
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- 2024
14. Gemini 1.5: Unlocking multimodal understanding across millions of tokens of context
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Gemini Team, Georgiev, Petko, Lei, Ving Ian, Burnell, Ryan, Bai, Libin, Gulati, Anmol, Tanzer, Garrett, Vincent, Damien, Pan, Zhufeng, Wang, Shibo, Mariooryad, Soroosh, Ding, Yifan, Geng, Xinyang, Alcober, Fred, Frostig, Roy, Omernick, Mark, Walker, Lexi, Paduraru, Cosmin, Sorokin, Christina, Tacchetti, Andrea, Gaffney, Colin, Daruki, Samira, Sercinoglu, Olcan, Gleicher, Zach, Love, Juliette, Voigtlaender, Paul, Jain, Rohan, Surita, Gabriela, Mohamed, Kareem, Blevins, Rory, Ahn, Junwhan, Zhu, Tao, Kawintiranon, Kornraphop, Firat, Orhan, Gu, Yiming, Zhang, Yujing, Rahtz, Matthew, Faruqui, Manaal, Clay, Natalie, Gilmer, Justin, Co-Reyes, JD, Penchev, Ivo, Zhu, Rui, Morioka, Nobuyuki, Hui, Kevin, Haridasan, Krishna, Campos, Victor, Mahdieh, Mahdis, Guo, Mandy, Hassan, Samer, Kilgour, Kevin, Vezer, Arpi, Cheng, Heng-Tze, de Liedekerke, Raoul, Goyal, Siddharth, Barham, Paul, Strouse, DJ, Noury, Seb, Adler, Jonas, Sundararajan, Mukund, Vikram, Sharad, Lepikhin, Dmitry, Paganini, Michela, Garcia, Xavier, Yang, Fan, Valter, Dasha, Trebacz, Maja, Vodrahalli, Kiran, Asawaroengchai, Chulayuth, Ring, Roman, Kalb, Norbert, Soares, Livio Baldini, Brahma, Siddhartha, Steiner, David, Yu, Tianhe, Mentzer, Fabian, He, Antoine, Gonzalez, Lucas, Xu, Bibo, Kaufman, Raphael Lopez, Shafey, Laurent El, Oh, Junhyuk, Hennigan, Tom, Driessche, George van den, Odoom, Seth, Lucic, Mario, Roelofs, Becca, Lall, Sid, Marathe, Amit, Chan, Betty, Ontanon, Santiago, He, Luheng, Teplyashin, Denis, Lai, Jonathan, Crone, Phil, Damoc, Bogdan, Ho, Lewis, Riedel, Sebastian, Lenc, Karel, Yeh, Chih-Kuan, Chowdhery, Aakanksha, Xu, Yang, Kazemi, Mehran, Amid, Ehsan, Petrushkina, Anastasia, Swersky, Kevin, Khodaei, Ali, Chen, Gowoon, Larkin, Chris, Pinto, Mario, Yan, Geng, Badia, Adria Puigdomenech, Patil, Piyush, Hansen, Steven, Orr, Dave, Arnold, Sebastien M. R., Grimstad, Jordan, Dai, Andrew, Douglas, Sholto, Sinha, Rishika, Yadav, Vikas, Chen, Xi, Gribovskaya, Elena, Austin, Jacob, Zhao, Jeffrey, Patel, Kaushal, Komarek, Paul, Austin, Sophia, Borgeaud, Sebastian, Friso, Linda, Goyal, Abhimanyu, Caine, Ben, Cao, Kris, Chung, Da-Woon, Lamm, Matthew, Barth-Maron, Gabe, Kagohara, Thais, Olszewska, Kate, Chen, Mia, Shivakumar, Kaushik, Agarwal, Rishabh, Godhia, Harshal, Rajwar, Ravi, Snaider, Javier, Dotiwalla, Xerxes, Liu, Yuan, Barua, Aditya, Ungureanu, Victor, Zhang, Yuan, Batsaikhan, Bat-Orgil, Wirth, Mateo, Qin, James, Danihelka, Ivo, Doshi, Tulsee, Chadwick, Martin, Chen, Jilin, Jain, Sanil, Le, Quoc, Kar, Arjun, Gurumurthy, Madhu, Li, Cheng, Sang, Ruoxin, Liu, Fangyu, Lamprou, Lampros, Munoz, Rich, Lintz, Nathan, Mehta, Harsh, Howard, Heidi, Reynolds, Malcolm, Aroyo, Lora, Wang, Quan, Blanco, Lorenzo, Cassirer, Albin, Griffith, Jordan, Das, Dipanjan, Lee, Stephan, Sygnowski, Jakub, Fisher, Zach, Besley, James, Powell, Richard, Ahmed, Zafarali, Paulus, Dominik, Reitter, David, Borsos, Zalan, Joshi, Rishabh, Pope, Aedan, Hand, Steven, Selo, Vittorio, Jain, Vihan, Sethi, Nikhil, Goel, Megha, Makino, Takaki, May, Rhys, Yang, Zhen, Schalkwyk, Johan, Butterfield, Christina, Hauth, Anja, Goldin, Alex, Hawkins, Will, Senter, Evan, Brin, Sergey, Woodman, Oliver, Ritter, Marvin, Noland, Eric, Giang, Minh, Bolina, Vijay, Lee, Lisa, Blyth, Tim, Mackinnon, Ian, Reid, Machel, Sarvana, Obaid, Silver, David, Chen, Alexander, Wang, Lily, Maggiore, Loren, Chang, Oscar, Attaluri, Nithya, Thornton, Gregory, Chiu, Chung-Cheng, Bunyan, Oskar, Levine, Nir, Chung, Timothy, Eltyshev, Evgenii, Si, Xiance, Lillicrap, Timothy, Brady, Demetra, Aggarwal, Vaibhav, Wu, Boxi, Xu, Yuanzhong, McIlroy, Ross, Badola, Kartikeya, Sandhu, Paramjit, Moreira, Erica, Stokowiec, Wojciech, Hemsley, Ross, Li, Dong, Tudor, Alex, Shyam, Pranav, Rahimtoroghi, Elahe, Haykal, Salem, Sprechmann, Pablo, Zhou, Xiang, Mincu, Diana, Li, Yujia, Addanki, Ravi, Krishna, Kalpesh, Wu, Xiao, Frechette, Alexandre, Eyal, Matan, Dafoe, Allan, Lacey, Dave, Whang, Jay, Avrahami, Thi, Zhang, Ye, Taropa, Emanuel, Lin, Hanzhao, Toyama, Daniel, Rutherford, Eliza, Sano, Motoki, Choe, HyunJeong, Tomala, Alex, Safranek-Shrader, Chalence, Kassner, Nora, Pajarskas, Mantas, Harvey, Matt, Sechrist, Sean, Fortunato, Meire, Lyu, Christina, Elsayed, Gamaleldin, Kuang, Chenkai, Lottes, James, Chu, Eric, Jia, Chao, Chen, Chih-Wei, Humphreys, Peter, Baumli, Kate, Tao, Connie, Samuel, Rajkumar, Santos, Cicero Nogueira dos, Andreassen, Anders, Rakićević, Nemanja, Grewe, Dominik, Kumar, Aviral, Winkler, Stephanie, Caton, Jonathan, Brock, Andrew, Dalmia, Sid, Sheahan, Hannah, Barr, Iain, Miao, Yingjie, Natsev, Paul, Devlin, Jacob, Behbahani, Feryal, Prost, Flavien, Sun, Yanhua, Myaskovsky, Artiom, Pillai, Thanumalayan Sankaranarayana, Hurt, Dan, Lazaridou, Angeliki, Xiong, Xi, Zheng, Ce, Pardo, Fabio, Li, Xiaowei, Horgan, Dan, Stanton, Joe, Ambar, Moran, Xia, Fei, Lince, Alejandro, Wang, Mingqiu, Mustafa, Basil, Webson, Albert, Lee, Hyo, Anil, Rohan, Wicke, Martin, Dozat, Timothy, Sinha, Abhishek, Piqueras, Enrique, Dabir, Elahe, Upadhyay, Shyam, Boral, Anudhyan, Hendricks, Lisa Anne, Fry, Corey, Djolonga, Josip, Su, Yi, Walker, Jake, Labanowski, Jane, Huang, Ronny, Misra, Vedant, Chen, Jeremy, Skerry-Ryan, RJ, Singh, Avi, Rijhwani, Shruti, Yu, Dian, Castro-Ros, Alex, Changpinyo, Beer, Datta, Romina, Bagri, Sumit, Hrafnkelsson, Arnar Mar, Maggioni, Marcello, Zheng, Daniel, Sulsky, Yury, Hou, Shaobo, Paine, Tom Le, Yang, Antoine, Riesa, Jason, Rogozinska, Dominika, Marcus, Dror, Badawy, Dalia El, Zhang, Qiao, Wang, Luyu, Miller, Helen, Greer, Jeremy, Sjos, Lars Lowe, Nova, Azade, Zen, Heiga, Chaabouni, Rahma, Rosca, Mihaela, Jiang, Jiepu, Chen, Charlie, Liu, Ruibo, Sainath, Tara, Krikun, Maxim, Polozov, Alex, Lespiau, Jean-Baptiste, Newlan, Josh, Cankara, Zeyncep, Kwak, Soo, Xu, Yunhan, Chen, Phil, Coenen, Andy, Meyer, Clemens, Tsihlas, Katerina, Ma, Ada, Gottweis, Juraj, Xing, Jinwei, Gu, Chenjie, Miao, Jin, Frank, Christian, Cankara, Zeynep, Ganapathy, Sanjay, Dasgupta, Ishita, Hughes-Fitt, Steph, Chen, Heng, Reid, David, Rong, Keran, Fan, Hongmin, van Amersfoort, Joost, Zhuang, Vincent, Cohen, Aaron, Gu, Shixiang Shane, Mohananey, Anhad, Ilic, Anastasija, Tobin, Taylor, Wieting, John, Bortsova, Anna, Thacker, Phoebe, Wang, Emma, Caveness, Emily, Chiu, Justin, Sezener, Eren, Kaskasoli, Alex, Baker, Steven, Millican, Katie, Elhawaty, Mohamed, Aisopos, Kostas, Lebsack, Carl, Byrd, Nathan, Dai, Hanjun, Jia, Wenhao, Wiethoff, Matthew, Davoodi, Elnaz, Weston, Albert, Yagati, Lakshman, Ahuja, Arun, Gao, Isabel, Pundak, Golan, Zhang, Susan, Azzam, Michael, Sim, Khe Chai, Caelles, Sergi, Keeling, James, Sharma, Abhanshu, Swing, Andy, Li, YaGuang, Liu, Chenxi, Bostock, Carrie Grimes, Bansal, Yamini, Nado, Zachary, Anand, Ankesh, Lipschultz, Josh, Karmarkar, Abhijit, Proleev, Lev, Ittycheriah, Abe, Yeganeh, Soheil Hassas, Polovets, George, Faust, Aleksandra, Sun, Jiao, Rrustemi, Alban, Li, Pen, Shivanna, Rakesh, Liu, Jeremiah, Welty, Chris, Lebron, Federico, Baddepudi, Anirudh, Krause, Sebastian, Parisotto, Emilio, Soricut, Radu, Xu, Zheng, Bloxwich, Dawn, Johnson, Melvin, Neyshabur, Behnam, Mao-Jones, Justin, Wang, Renshen, Ramasesh, Vinay, Abbas, Zaheer, Guez, Arthur, Segal, Constant, Nguyen, Duc Dung, Svensson, James, Hou, Le, York, Sarah, Milan, Kieran, Bridgers, Sophie, Gworek, Wiktor, Tagliasacchi, Marco, Lee-Thorp, James, Chang, Michael, Guseynov, Alexey, Hartman, Ale Jakse, Kwong, Michael, Zhao, Ruizhe, Kashem, Sheleem, Cole, Elizabeth, Miech, Antoine, Tanburn, Richard, Phuong, Mary, Pavetic, Filip, Cevey, Sebastien, Comanescu, Ramona, Ives, Richard, Yang, Sherry, Du, Cosmo, Li, Bo, Zhang, Zizhao, Iinuma, Mariko, Hu, Clara Huiyi, Roy, Aurko, Bijwadia, Shaan, Zhu, Zhenkai, Martins, Danilo, Saputro, Rachel, Gergely, Anita, Zheng, Steven, Jia, Dawei, Antonoglou, Ioannis, Sadovsky, Adam, Gu, Shane, Bi, Yingying, Andreev, Alek, Samangooei, Sina, Khan, Mina, Kocisky, Tomas, Filos, Angelos, Kumar, Chintu, Bishop, Colton, Yu, Adams, Hodkinson, Sarah, Mittal, Sid, Shah, Premal, Moufarek, Alexandre, Cheng, Yong, Bloniarz, Adam, Lee, Jaehoon, Pejman, Pedram, Michel, Paul, Spencer, Stephen, Feinberg, Vladimir, Xiong, Xuehan, Savinov, Nikolay, Smith, Charlotte, Shakeri, Siamak, Tran, Dustin, Chesus, Mary, Bohnet, Bernd, Tucker, George, von Glehn, Tamara, Muir, Carrie, Mao, Yiran, Kazawa, Hideto, Slone, Ambrose, Soparkar, Kedar, Shrivastava, Disha, Cobon-Kerr, James, Sharman, Michael, Pavagadhi, Jay, Araya, Carlos, Misiunas, Karolis, Ghelani, Nimesh, Laskin, Michael, Barker, David, Li, Qiujia, Briukhov, Anton, Houlsby, Neil, Glaese, Mia, Lakshminarayanan, Balaji, Schucher, Nathan, Tang, Yunhao, Collins, Eli, Lim, Hyeontaek, Feng, Fangxiaoyu, Recasens, Adria, Lai, Guangda, Magni, Alberto, De Cao, Nicola, Siddhant, Aditya, Ashwood, Zoe, Orbay, Jordi, Dehghani, Mostafa, Brennan, Jenny, He, Yifan, Xu, Kelvin, Gao, Yang, Saroufim, Carl, Molloy, James, Wu, Xinyi, Arnold, Seb, Chang, Solomon, Schrittwieser, Julian, Buchatskaya, Elena, Radpour, Soroush, Polacek, Martin, Giordano, Skye, Bapna, Ankur, Tokumine, Simon, Hellendoorn, Vincent, Sottiaux, Thibault, Cogan, Sarah, Severyn, Aliaksei, Saleh, Mohammad, Thakoor, Shantanu, Shefey, Laurent, Qiao, Siyuan, Gaba, Meenu, Chang, Shuo-yiin, Swanson, Craig, Zhang, Biao, Lee, Benjamin, Rubenstein, Paul Kishan, Song, Gan, Kwiatkowski, Tom, Koop, Anna, Kannan, Ajay, Kao, David, Schuh, Parker, Stjerngren, Axel, Ghiasi, Golnaz, Gibson, Gena, Vilnis, Luke, Yuan, Ye, Ferreira, Felipe Tiengo, Kamath, Aishwarya, Klimenko, Ted, Franko, Ken, Xiao, Kefan, Bhattacharya, Indro, Patel, Miteyan, Wang, Rui, Morris, Alex, Strudel, Robin, Sharma, Vivek, Choy, Peter, Hashemi, Sayed Hadi, Landon, Jessica, Finkelstein, Mara, Jhakra, Priya, Frye, Justin, Barnes, Megan, Mauger, Matthew, Daun, Dennis, Baatarsukh, Khuslen, Tung, Matthew, Farhan, Wael, Michalewski, Henryk, Viola, Fabio, Quitry, Felix de Chaumont, Lan, Charline Le, Hudson, Tom, Wang, Qingze, Fischer, Felix, Zheng, Ivy, White, Elspeth, Dragan, Anca, Alayrac, Jean-baptiste, Ni, Eric, Pritzel, Alexander, Iwanicki, Adam, Isard, Michael, Bulanova, Anna, Zilka, Lukas, Dyer, Ethan, Sachan, Devendra, Srinivasan, Srivatsan, Muckenhirn, Hannah, Cai, Honglong, Mandhane, Amol, Tariq, Mukarram, Rae, Jack W., Wang, Gary, Ayoub, Kareem, FitzGerald, Nicholas, Zhao, Yao, Han, Woohyun, Alberti, Chris, Garrette, Dan, Krishnakumar, Kashyap, Gimenez, Mai, Levskaya, Anselm, Sohn, Daniel, Matak, Josip, Iturrate, Inaki, Chang, Michael B., Xiang, Jackie, Cao, Yuan, Ranka, Nishant, Brown, Geoff, Hutter, Adrian, Mirrokni, Vahab, Chen, Nanxin, Yao, Kaisheng, Egyed, Zoltan, Galilee, Francois, Liechty, Tyler, Kallakuri, Praveen, Palmer, Evan, Ghemawat, Sanjay, Liu, Jasmine, Tao, David, Thornton, Chloe, Green, Tim, Jasarevic, Mimi, Lin, Sharon, Cotruta, Victor, Tan, Yi-Xuan, Fiedel, Noah, Yu, Hongkun, Chi, Ed, Neitz, Alexander, Heitkaemper, Jens, Sinha, Anu, Zhou, Denny, Sun, Yi, Kaed, Charbel, Hulse, Brice, Mishra, Swaroop, Georgaki, Maria, Kudugunta, Sneha, Farabet, Clement, Shafran, Izhak, Vlasic, Daniel, Tsitsulin, Anton, Ananthanarayanan, Rajagopal, Carin, Alen, Su, Guolong, Sun, Pei, V, Shashank, Carvajal, Gabriel, Broder, Josef, Comsa, Iulia, Repina, Alena, Wong, William, Chen, Warren Weilun, Hawkins, Peter, Filonov, Egor, Loher, Lucia, Hirnschall, Christoph, Wang, Weiyi, Ye, Jingchen, Burns, Andrea, Cate, Hardie, Wright, Diana Gage, Piccinini, Federico, Zhang, Lei, Lin, Chu-Cheng, Gog, Ionel, Kulizhskaya, Yana, Sreevatsa, Ashwin, Song, Shuang, Cobo, Luis C., Iyer, Anand, Tekur, Chetan, Garrido, Guillermo, Xiao, Zhuyun, Kemp, Rupert, Zheng, Huaixiu Steven, Li, Hui, Agarwal, Ananth, Ngani, Christel, Goshvadi, Kati, Santamaria-Fernandez, Rebeca, Fica, Wojciech, Chen, Xinyun, Gorgolewski, Chris, Sun, Sean, Garg, Roopal, Ye, Xinyu, Eslami, S. M. Ali, Hua, Nan, Simon, Jon, Joshi, Pratik, Kim, Yelin, Tenney, Ian, Potluri, Sahitya, Thiet, Lam Nguyen, Yuan, Quan, Luisier, Florian, Chronopoulou, Alexandra, Scellato, Salvatore, Srinivasan, Praveen, Chen, Minmin, Koverkathu, Vinod, Dalibard, Valentin, Xu, Yaming, Saeta, Brennan, Anderson, Keith, Sellam, Thibault, Fernando, Nick, Huot, Fantine, Jung, Junehyuk, Varadarajan, Mani, Quinn, Michael, Raul, Amit, Le, Maigo, Habalov, Ruslan, Clark, Jon, Jalan, Komal, Bullard, Kalesha, Singhal, Achintya, Luong, Thang, Wang, Boyu, Rajayogam, Sujeevan, Eisenschlos, Julian, Jia, Johnson, Finchelstein, Daniel, Yakubovich, Alex, Balle, Daniel, Fink, Michael, Agarwal, Sameer, Li, Jing, Dvijotham, Dj, Pal, Shalini, Kang, Kai, Konzelmann, Jaclyn, Beattie, Jennifer, Dousse, Olivier, Wu, Diane, Crocker, Remi, Elkind, Chen, Jonnalagadda, Siddhartha Reddy, Lee, Jong, Holtmann-Rice, Dan, Kallarackal, Krystal, Liu, Rosanne, Vnukov, Denis, Vats, Neera, Invernizzi, Luca, Jafari, Mohsen, Zhou, Huanjie, Taylor, Lilly, Prendki, Jennifer, Wu, Marcus, Eccles, Tom, Liu, Tianqi, Kopparapu, Kavya, Beaufays, Francoise, Angermueller, Christof, Marzoca, Andreea, Sarcar, Shourya, Dib, Hilal, Stanway, Jeff, Perbet, Frank, Trdin, Nejc, Sterneck, Rachel, Khorlin, Andrey, Li, Dinghua, Wu, Xihui, Goenka, Sonam, Madras, David, Goldshtein, Sasha, Gierke, Willi, Zhou, Tong, Liu, Yaxin, Liang, Yannie, White, Anais, Li, Yunjie, Singh, Shreya, Bahargam, Sanaz, Epstein, Mark, Basu, Sujoy, Lao, Li, Ozturel, Adnan, Crous, Carl, Zhai, Alex, Lu, Han, Tung, Zora, Gaur, Neeraj, Walton, Alanna, Dixon, Lucas, Zhang, Ming, Globerson, Amir, Uy, Grant, Bolt, Andrew, Wiles, Olivia, Nasr, Milad, Shumailov, Ilia, Selvi, Marco, Piccinno, Francesco, Aguilar, Ricardo, McCarthy, Sara, Khalman, Misha, Shukla, Mrinal, Galic, Vlado, Carpenter, John, Villela, Kevin, Zhang, Haibin, Richardson, Harry, Martens, James, Bosnjak, Matko, Belle, Shreyas Rammohan, Seibert, Jeff, Alnahlawi, Mahmoud, McWilliams, Brian, Singh, Sankalp, Louis, Annie, Ding, Wen, Popovici, Dan, Simicich, Lenin, Knight, Laura, Mehta, Pulkit, Gupta, Nishesh, Shi, Chongyang, Fatehi, Saaber, Mitrovic, Jovana, Grills, Alex, Pagadora, Joseph, Petrova, Dessie, Eisenbud, Danielle, Zhang, Zhishuai, Yates, Damion, Mittal, Bhavishya, Tripuraneni, Nilesh, Assael, Yannis, Brovelli, Thomas, Jain, Prateek, Velimirovic, Mihajlo, Akbulut, Canfer, Mu, Jiaqi, Macherey, Wolfgang, Kumar, Ravin, Xu, Jun, Qureshi, Haroon, Comanici, Gheorghe, Wiesner, Jeremy, Gong, Zhitao, Ruddock, Anton, Bauer, Matthias, Felt, Nick, GP, Anirudh, Arnab, Anurag, Zelle, Dustin, Rothfuss, Jonas, Rosgen, Bill, Shenoy, Ashish, Seybold, Bryan, Li, Xinjian, Mudigonda, Jayaram, Erdogan, Goker, Xia, Jiawei, Simsa, Jiri, Michi, Andrea, Yao, Yi, Yew, Christopher, Kan, Steven, Caswell, Isaac, Radebaugh, Carey, Elisseeff, Andre, Valenzuela, Pedro, McKinney, Kay, Paterson, Kim, Cui, Albert, Latorre-Chimoto, Eri, Kim, Solomon, Zeng, William, Durden, Ken, Ponnapalli, Priya, Sosea, Tiberiu, Choquette-Choo, Christopher A., Manyika, James, Robenek, Brona, Vashisht, Harsha, Pereira, Sebastien, Lam, Hoi, Velic, Marko, Owusu-Afriyie, Denese, Lee, Katherine, Bolukbasi, Tolga, Parrish, Alicia, Lu, Shawn, Park, Jane, Venkatraman, Balaji, Talbert, Alice, Rosique, Lambert, Cheng, Yuchung, Sozanschi, Andrei, Paszke, Adam, Kumar, Praveen, Austin, Jessica, Li, Lu, Salama, Khalid, Kim, Wooyeol, Dukkipati, Nandita, Baryshnikov, Anthony, Kaplanis, Christos, Sheng, XiangHai, Chervonyi, Yuri, Unlu, Caglar, Casas, Diego de Las, Askham, Harry, Tunyasuvunakool, Kathryn, Gimeno, Felix, Poder, Siim, Kwak, Chester, Miecnikowski, Matt, Dimitriev, Alek, Parisi, Aaron, Liu, Dangyi, Tsai, Tomy, Shevlane, Toby, Kouridi, Christina, Garmon, Drew, Goedeckemeyer, Adrian, Brown, Adam R., Vijayakumar, Anitha, Elqursh, Ali, Jazayeri, Sadegh, Huang, Jin, Carthy, Sara Mc, Hoover, Jay, Kim, Lucy, Kumar, Sandeep, Chen, Wei, Biles, Courtney, Bingham, Garrett, Rosen, Evan, Wang, Lisa, Tan, Qijun, Engel, David, Pongetti, Francesco, de Cesare, Dario, Hwang, Dongseong, Yu, Lily, Pullman, Jennifer, Narayanan, Srini, Levin, Kyle, Gopal, Siddharth, Li, Megan, Aharoni, Asaf, Trinh, Trieu, Lo, Jessica, Casagrande, Norman, Vij, Roopali, Matthey, Loic, Ramadhana, Bramandia, Matthews, Austin, Carey, CJ, Johnson, Matthew, Goranova, Kremena, Shah, Rohin, Ashraf, Shereen, Dasgupta, Kingshuk, Larsen, Rasmus, Wang, Yicheng, Vuyyuru, Manish Reddy, Jiang, Chong, Ijazi, Joana, Osawa, Kazuki, Smith, Celine, Boppana, Ramya Sree, Bilal, Taylan, Koizumi, Yuma, Xu, Ying, Altun, Yasemin, Shabat, Nir, Bariach, Ben, Korchemniy, Alex, Choo, Kiam, Ronneberger, Olaf, Iwuanyanwu, Chimezie, Zhao, Shubin, Soergel, David, Hsieh, Cho-Jui, Cai, Irene, Iqbal, Shariq, Sundermeyer, Martin, Chen, Zhe, Bursztein, Elie, Malaviya, Chaitanya, Biadsy, Fadi, Shroff, Prakash, Dhillon, Inderjit, Latkar, Tejasi, Dyer, Chris, Forbes, Hannah, Nicosia, Massimo, Nikolaev, Vitaly, Greene, Somer, Georgiev, Marin, Wang, Pidong, Martin, Nina, Sedghi, Hanie, Zhang, John, Banzal, Praseem, Fritz, Doug, Rao, Vikram, Wang, Xuezhi, Zhang, Jiageng, Patraucean, Viorica, Du, Dayou, Mordatch, Igor, Jurin, Ivan, Liu, Lewis, Dubey, Ayush, Mohan, Abhi, Nowakowski, Janek, Ion, Vlad-Doru, Wei, Nan, Tojo, Reiko, Raad, Maria Abi, Hudson, Drew A., Keshava, Vaishakh, Agrawal, Shubham, Ramirez, Kevin, Wu, Zhichun, Nguyen, Hoang, Liu, Ji, Sewak, Madhavi, Petrini, Bryce, Choi, DongHyun, Philips, Ivan, Wang, Ziyue, Bica, Ioana, Garg, Ankush, Wilkiewicz, Jarek, Agrawal, Priyanka, Guo, Danhao, Xue, Emily, Shaik, Naseer, Leach, Andrew, Khan, Sadh MNM, Wiesinger, Julia, Jerome, Sammy, Chakladar, Abhishek, Wang, Alek Wenjiao, Ornduff, Tina, Abu, Folake, Ghaffarkhah, Alireza, Wainwright, Marcus, Cortes, Mario, Liu, Frederick, Maynez, Joshua, Terzis, Andreas, Samangouei, Pouya, Mansour, Riham, Kępa, Tomasz, Aubet, François-Xavier, Algymr, Anton, Banica, Dan, Weisz, Agoston, Orban, Andras, Senges, Alexandre, Andrejczuk, Ewa, Geller, Mark, Santo, Niccolo Dal, Anklin, Valentin, Merey, Majd Al, Baeuml, Martin, Strohman, Trevor, Bai, Junwen, Petrov, Slav, Wu, Yonghui, Hassabis, Demis, Kavukcuoglu, Koray, Dean, Jeffrey, and Vinyals, Oriol
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Computer Science - Computation and Language ,Computer Science - Artificial Intelligence - Abstract
In this report, we introduce the Gemini 1.5 family of models, representing the next generation of highly compute-efficient multimodal models capable of recalling and reasoning over fine-grained information from millions of tokens of context, including multiple long documents and hours of video and audio. The family includes two new models: (1) an updated Gemini 1.5 Pro, which exceeds the February version on the great majority of capabilities and benchmarks; (2) Gemini 1.5 Flash, a more lightweight variant designed for efficiency with minimal regression in quality. Gemini 1.5 models achieve near-perfect recall on long-context retrieval tasks across modalities, improve the state-of-the-art in long-document QA, long-video QA and long-context ASR, and match or surpass Gemini 1.0 Ultra's state-of-the-art performance across a broad set of benchmarks. Studying the limits of Gemini 1.5's long-context ability, we find continued improvement in next-token prediction and near-perfect retrieval (>99%) up to at least 10M tokens, a generational leap over existing models such as Claude 3.0 (200k) and GPT-4 Turbo (128k). Finally, we highlight real-world use cases, such as Gemini 1.5 collaborating with professionals on completing their tasks achieving 26 to 75% time savings across 10 different job categories, as well as surprising new capabilities of large language models at the frontier; when given a grammar manual for Kalamang, a language with fewer than 200 speakers worldwide, the model learns to translate English to Kalamang at a similar level to a person who learned from the same content.
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- 2024
15. Deep Confident Steps to New Pockets: Strategies for Docking Generalization
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Corso, Gabriele, Deng, Arthur, Fry, Benjamin, Polizzi, Nicholas, Barzilay, Regina, and Jaakkola, Tommi
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Quantitative Biology - Biomolecules ,Computer Science - Machine Learning - Abstract
Accurate blind docking has the potential to lead to new biological breakthroughs, but for this promise to be realized, docking methods must generalize well across the proteome. Existing benchmarks, however, fail to rigorously assess generalizability. Therefore, we develop DockGen, a new benchmark based on the ligand-binding domains of proteins, and we show that existing machine learning-based docking models have very weak generalization abilities. We carefully analyze the scaling laws of ML-based docking and show that, by scaling data and model size, as well as integrating synthetic data strategies, we are able to significantly increase the generalization capacity and set new state-of-the-art performance across benchmarks. Further, we propose Confidence Bootstrapping, a new training paradigm that solely relies on the interaction between diffusion and confidence models and exploits the multi-resolution generation process of diffusion models. We demonstrate that Confidence Bootstrapping significantly improves the ability of ML-based docking methods to dock to unseen protein classes, edging closer to accurate and generalizable blind docking methods.
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- 2024
16. Simulating decoherence of coupled two spin qubits using generalized cluster correlation expansion
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Chen, Xiao, Hoffman, Silas, Fry, James N., and Cheng, Hai-Ping
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Quantum Physics ,Physics - Computational Physics - Abstract
We study the coherence of two coupled spin qubits in the presence of a bath of nuclear spins simulated using generalized cluster correlation expansion (gCCE) method. In our model, two electron spin qubits coupled with isotropic exchange or magnetic dipolar interactions interact with an environment of random nuclear spins. We study the time-evolution of the two-qubit reduced density matrix (RDM) and resulting decay of the off diagonal elements, corresponding to decoherence, which allows us to calculate gate fidelity in the regime of pure dephasing. We contrast decoherence when the system undergoes free evolution and evolution with dynamical decoupling pulses applied. Moreover, we study the dependence of decoherence on external magnetic field and system parameters which mimic realistic spin qubits, emphasizing magnetic molecules. Lastly, we comment on the application and limitations of gCCE in simulating nuclear-spin induced two-qubit relaxation processes.
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- 2024
17. A Brauer--Galois height zero conjecture
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Malle, Gunter, Moretó, Alexander, Rizo, Noelia, and Fry, A. A. Schaeffer
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Mathematics - Representation Theory ,Mathematics - Group Theory ,20C15, 20C20, 20C33 - Abstract
Recently, Malle and Navarro obtained a Galois strengthening of Brauer's height zero conjecture for principal $p$-blocks when $p=2$, considering a particular Galois automorphism of order~$2$. In this paper, for any prime $p$ we consider a certain elementary abelian $p$-subgroup of the absolute Galois group and propose a Galois version of Brauer's height zero conjecture for principal $p$-blocks. We prove it when $p=2$ and also for arbitrary $p$ when $G$ does not involve certain groups of Lie type of small rank as composition factors. Furthermore, we prove it for almost simple groups and for $p$-solvable groups., Comment: a few minor improvements over version 1
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- 2024
18. Navigating tensions in climate change-related planned relocation
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Gini, Giovanna, Piggott-McKellar, Annah, Wiegel, Hanne, Neu, Friedrich Nikolaus, Link, Ann-Christine, Fry, Claudia, Tabe, Tammy, Adegun, Olumuyiwa, Wade, Cheikh Tidiane, Bower, Erica Rose, Koeltzow, Sarah, Harrington-Abrams, Rachel, Jacobs, Carolien, van der Geest, Kees, Zivdar, Narjes, Alaniz, Ryan, Cherop, Carolyne, Durand-Delacre, David, Pill, Melanie, Shekhar, Himanshu, Yates, Olivia, Khan, Md Abdul Awal, Nansam-Aggrey, Frank Kwesi, Grant, Lauren, Nizar, Danang Aditya, Owusu-Daaku, Kwame Nitri, Preato, Alberto, Stefancu, Oana, and Yee, Merewalesi
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- 2024
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19. Assessment of knowledge, attitude, and use of complementary and integrative medicine among health-major students in Western Pennsylvania and their implications on ethics education
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Aramesh, Kiarash, Etemadi, Arash, Sines, Lindsay, Fry, Alayna, Coe, Taylor, and Tucker, Kaylan
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- 2024
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20. Targeting TGFβ-activated kinase-1 activation in microglia reduces CAR T immune effector cell-associated neurotoxicity syndrome
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Vinnakota, Janaki Manoja, Biavasco, Francesca, Schwabenland, Marius, Chhatbar, Chintan, Adams, Rachael C., Erny, Daniel, Duquesne, Sandra, El Khawanky, Nadia, Schmidt, Dominik, Fetsch, Viktor, Zähringer, Alexander, Salié, Henrike, Athanassopoulos, Dimitrios, Braun, Lukas M., Javorniczky, Nora R., Ho, Jenny N. H. G., Kierdorf, Katrin, Marks, Reinhard, Wäsch, Ralph, Simonetta, Federico, Andrieux, Geoffroy, Pfeifer, Dietmar, Monaco, Gianni, Capitini, Christian, Fry, Terry J., Blank, Thomas, Blazar, Bruce R., Wagner, Eva, Theobald, Matthias, Sommer, Clemens, Stelljes, Matthias, Reicherts, Christian, Jeibmann, Astrid, Schittenhelm, Jens, Monoranu, Camelia-Maria, Rosenwald, Andreas, Kortüm, Martin, Rasche, Leo, Einsele, Hermann, Meyer, Philipp T., Brumberg, Joachim, Völkl, Simon, Mackensen, Andreas, Coras, Roland, von Bergwelt-Baildon, Michael, Albert, Nathalie L., Bartos, Laura M., Brendel, Matthias, Holzgreve, Adrien, Mack, Matthias, Boerries, Melanie, Mackall, Crystal L., Duyster, Justus, Henneke, Philipp, Priller, Josef, Köhler, Natalie, Strübing, Felix, Bengsch, Bertram, Ruella, Marco, Subklewe, Marion, von Baumgarten, Louisa, Gill, Saar, Prinz, Marco, and Zeiser, Robert
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- 2024
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21. Ionospheric irregularities at Jupiter observed by JWST
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Melin, Henrik, O’Donoghue, J., Moore, L., Stallard, T. S., Fletcher, L. N., Roman, M. T., Harkett, J., King, O. R. T., Thomas, E. M., Wang, R., Tiranti, P. I., Knowles, K. L., de Pater, I., Fouchet, T., Fry, P. H., Wong, M. H., Holler, B. J., Hueso, R., James, M. K., Orton, G. S., Mura, A., Sánchez-Lavega, A., Lellouch, E., de Kleer, K., and Showalter, M. R.
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- 2024
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22. Residual Stress Estimation Using Hole Drilling and Contour Methods in Rail Welds Treated with and without Ultrasonic Impact Treatment
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Bandyopadhyay, Ananyo, Fry, Gary T., and Watanabe, Brett
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- 2024
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23. Epigenetic associations in HPA axis genes related to bronchopulmonary dysplasia and antenatal steroids
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Hodge, Kenyaita M., Zhabotynsky, Vasyl, Burt, Amber A., Carter, Brian S., Fry, Rebecca C., Helderman, Jennifer, Hofheimer, Julie A., McGowan, Elisabeth C., Neal, Charles R., Pastyrnak, Steven L., Smith, Lynne M., DellaGrotta, Sheri A., Dansereau, Lynne M., Lester, Barry M., Marsit, Carmen J., O’Shea, T. Michael, and Everson, Todd M.
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- 2024
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24. Online Modules for Community-Engaged Learning during a Global Pandemic
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Lancaster, Alexander, Bonella, Barrett, Gesteland, Becky Jo, Tadlock, Patrick, and Fry, Richard
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In the summer of 2020, our team created virtual community-engaged learning (VCEL) modules in response to the need to move classes to online and hybrid delivery styles during the height of the COVID-19 pandemic. These modules addressed engaged learning concepts and were designed with faculty, students, and community partner organizations in mind. This paper explores the challenges of creating and beta testing these VCEL modules, as well as the creative methods taken to produce high-quality content that would continue to serve students in the wake of the pandemic. What emerged from this project is a unique set of self-contained learning modules in Canvas Commons that include built-in assessments, allowing students to demonstrate learning, and allowing faculty members to review engaged-learning theory and strategies and integrate the virtual content into their online classes seamlessly. Our beta test findings indicate that students generally had a positive experience with the content and spent approximately two hours, on average, engaging with the material. In this reflective analysis of our process, we offer an explanation of the replicable process of creating VCEL modules and a description of the outcomes associated with producing and testing the content therein.
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- 2023
25. Researching COVID to enhance recovery (RECOVER) pediatric study protocol: Rationale, objectives and design.
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Gross, Rachel, Thaweethai, Tanayott, Rosenzweig, Erika, Chan, James, Chibnik, Lori, Cicek, Mine, Elliott, Amy, Flaherman, Valerie, Foulkes, Andrea, Gage Witvliet, Margot, Gallagher, Richard, Gennaro, Maria, Jernigan, Terry, Karlson, Elizabeth, Katz, Stuart, Kinser, Patricia, Kleinman, Lawrence, Lamendola-Essel, Michelle, Milner, Joshua, Mohandas, Sindhu, Mudumbi, Praveen, Newburger, Jane, Rhee, Kay, Salisbury, Amy, Snowden, Jessica, Stein, Cheryl, Stockwell, Melissa, Tantisira, Kelan, Thomason, Moriah, Truong, Dongngan, Warburton, David, Wood, John, Ahmed, Shifa, Akerlundh, Almary, Alshawabkeh, Akram, Anderson, Brett, Aschner, Judy, Atz, Andrew, Aupperle, Robin, Baker, Fiona, Balaraman, Venkataraman, Banerjee, Dithi, Barch, Deanna, Baskin-Sommers, Arielle, Bhuiyan, Sultana, Bind, Marie-Abele, Bogie, Amanda, Bradford, Tamara, Buchbinder, Natalie, Bueler, Elliott, Bükülmez, Hülya, Casey, B, Chang, Linda, Chrisant, Maryanne, Clark, Duncan, Clifton, Rebecca, Clouser, Katharine, Cottrell, Lesley, Cowan, Kelly, DSa, Viren, Dapretto, Mirella, Dasgupta, Soham, Dehority, Walter, Dionne, Audrey, Dummer, Kirsten, Elias, Matthew, Esquenazi-Karonika, Shari, Evans, Danielle, Faustino, E, Fiks, Alexander, Forsha, Daniel, Foxe, John, Friedman, Naomi, Fry, Greta, Gaur, Sunanda, Gee, Dylan, Gray, Kevin, Handler, Stephanie, Harahsheh, Ashraf, Hasbani, Keren, Heath, Andrew, Hebson, Camden, Heitzeg, Mary, Hester, Christina, Hill, Sophia, Hobart-Porter, Laura, Hong, Travis, Horowitz, Carol, Hsia, Daniel, Huentelman, Matthew, Hummel, Kathy, Irby, Katherine, Jacobus, Joanna, Jacoby, Vanessa, Jone, Pei-Ni, Kaelber, David, Kasmarcak, Tyler, Kluko, Matthew, Kosut, Jessica, and Laird, Angela
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Humans ,COVID-19 ,Adolescent ,Child ,Child ,Preschool ,Female ,Young Adult ,Adult ,Male ,Infant ,SARS-CoV-2 ,Infant ,Newborn ,Prospective Studies ,Research Design ,Cohort Studies ,Post-Acute COVID-19 Syndrome - Abstract
IMPORTANCE: The prevalence, pathophysiology, and long-term outcomes of COVID-19 (post-acute sequelae of SARS-CoV-2 [PASC] or Long COVID) in children and young adults remain unknown. Studies must address the urgent need to define PASC, its mechanisms, and potential treatment targets in children and young adults. OBSERVATIONS: We describe the protocol for the Pediatric Observational Cohort Study of the NIHs REsearching COVID to Enhance Recovery (RECOVER) Initiative. RECOVER-Pediatrics is an observational meta-cohort study of caregiver-child pairs (birth through 17 years) and young adults (18 through 25 years), recruited from more than 100 sites across the US. This report focuses on two of four cohorts that comprise RECOVER-Pediatrics: 1) a de novo RECOVER prospective cohort of children and young adults with and without previous or current infection; and 2) an extant cohort derived from the Adolescent Brain Cognitive Development (ABCD) study (n = 10,000). The de novo cohort incorporates three tiers of data collection: 1) remote baseline assessments (Tier 1, n = 6000); 2) longitudinal follow-up for up to 4 years (Tier 2, n = 6000); and 3) a subset of participants, primarily the most severely affected by PASC, who will undergo deep phenotyping to explore PASC pathophysiology (Tier 3, n = 600). Youth enrolled in the ABCD study participate in Tier 1. The pediatric protocol was developed as a collaborative partnership of investigators, patients, researchers, clinicians, community partners, and federal partners, intentionally promoting inclusivity and diversity. The protocol is adaptive to facilitate responses to emerging science. CONCLUSIONS AND RELEVANCE: RECOVER-Pediatrics seeks to characterize the clinical course, underlying mechanisms, and long-term effects of PASC from birth through 25 years old. RECOVER-Pediatrics is designed to elucidate the epidemiology, four-year clinical course, and sociodemographic correlates of pediatric PASC. The data and biosamples will allow examination of mechanistic hypotheses and biomarkers, thus providing insights into potential therapeutic interventions. CLINICAL TRIALS.GOV IDENTIFIER: Clinical Trial Registration: http://www.clinicaltrials.gov. Unique identifier: NCT05172011.
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- 2024
26. Faster identification of faster Formula 1 drivers via time-rank duality
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Fry, John, Brighton, Tom, and Fanzon, Silvio
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Statistics - Applications ,Mathematics - Probability ,62P25, 91-10, 62M99, 65C05 - Abstract
Two natural ways of modelling Formula 1 race outcomes are a probabilistic approach, based on the exponential distribution, and econometric modelling of the ranks. Both approaches lead to exactly soluble race-winning probabilities. Equating race-winning probabilities leads to a set of equivalent parametrisations. This time-rank duality is attractive theoretically and leads to quicker ways of dis-entangling driver and car level effects., Comment: 9 pages
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- 2023
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27. Quantum Time Series Similarity Measures and Quantum Temporal Kernels
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Markov, Vanio, Rastunkov, Vladimir, and Fry, Daniel
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Quantum Physics - Abstract
This article presents a quantum computing approach to designing of similarity measures and kernels for classification of stochastic symbolic time series. In the area of machine learning, kernels are important components of various similarity-based classification, clustering, and regression algorithms. An effective strategy for devising problem-specific kernels is leveraging existing generative models of the example space. In this study we assume that a quantum generative model, known as quantum hidden Markov model (QHMM), describes the underlying distributions of the examples. The sequence structure and probability are determined by transitions within model's density operator space. Consequently, the QHMM defines a mapping from the example space into the broader quantum space of density operators. Sequence similarity is evaluated using divergence measures such as trace and Bures distances between quantum states. We conducted extensive simulations to explore the relationship between the distribution of kernel-estimated similarity and the dimensionality of the QHMMs Hilbert space. As anticipated, a higher dimension of the Hilbert space corresponds to greater sequence distances and a more distinct separation of the examples. To empirically evaluate the performance of the kernels, we defined classification tasks based on a simplified generative model of directional price movement in the stock market. We implemented two widely-used kernel-based algorithms - support vector machines and k-nearest neighbors - using both classical and quantum kernels. Across all classification task scenarios, the quantum kernels consistently demonstrated superior performance compared to their classical counterparts., Comment: 25 pages, 18 figures
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- 2023
28. A Method of Moments Approach to Asymptotically Unbiased Synthetic Controls
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Fry, Joseph
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Economics - Econometrics - Abstract
A common approach to constructing a Synthetic Control unit is to fit on the outcome variable and covariates in pre-treatment time periods, but it has been shown by Ferman and Pinto (2019) that this approach does not provide asymptotic unbiasedness when the fit is imperfect and the number of controls is fixed. Many related panel methods have a similar limitation when the number of units is fixed. I introduce and evaluate a new method in which the Synthetic Control is constructed using a General Method of Moments approach where units not being included in the Synthetic Control are used as instruments. I show that a Synthetic Control Estimator of this form will be asymptotically unbiased as the number of pre-treatment time periods goes to infinity, even when pre-treatment fit is imperfect and the number of units is fixed. Furthermore, if both the number of pre-treatment and post-treatment time periods go to infinity, then averages of treatment effects can be consistently estimated. I conduct simulations and an empirical application to compare the performance of this method with existing approaches in the literature.
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- 2023
29. Comparing Optimization Targets for Contrast-Consistent Search
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Fry, Hugo, Fallows, Seamus, Fan, Ian, Wright, Jamie, and Schoots, Nandi
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Computer Science - Machine Learning ,Computer Science - Computation and Language - Abstract
We investigate the optimization target of Contrast-Consistent Search (CCS), which aims to recover the internal representations of truth of a large language model. We present a new loss function that we call the Midpoint-Displacement (MD) loss function. We demonstrate that for a certain hyper-parameter value this MD loss function leads to a prober with very similar weights to CCS. We further show that this hyper-parameter is not optimal and that with a better hyper-parameter the MD loss function attains a higher test accuracy than CCS., Comment: Socially Responsible Language Modelling Research (SoLaR) NeurIPS 2023
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- 2023
30. Composition and thermal properties of Ganymede's surface from JWST/NIRSpec and MIRI observations
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Bockelee-Morvan, D., Lellouch, E., Poch, O., Quirico, E., Cazaux, S., de Pater, I., Fouchet, T., Fry, P. M., Rodriguez-Ovalle, P., Tosi, F., Wong, M. H., Boshuizen, I., de Kleer, K., Fletcher, L. N., Meunier, L., Mura, A., Roth, L., Saur, J., Schmitt, B., Trumbo, S. K., Brown, M. E., O'Donoghue, J., Orton, G. S., and Showalter, M. R.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
JWST NIRSpec IFU (2.9-5.3 mu) and MIRI MRS (4.9-28.5 mu) observations were performed on both the leading and trailing hemispheres of Ganymede with a spectral resolution of ~2700. Reflectance spectra show signatures of water ice, CO2 and H2O2. An absorption feature at 5.9 mu is revealed and is tentatively assigned to sulfuric acid hydrates. The CO2 4.26-mu band shows latitudinal and longitudinal variations in depth, shape and position over the two hemispheres, unveiling different CO2 physical states. In the ice-rich polar regions, which are the most exposed to Jupiter's plasma irradiation, the CO2 band is redshifted with respect to other terrains. In the leading northern polar cap, the CO2 band is dominated by a high wavelength component at ~4.27 mu, consistent with CO2 trapped in amorphous water ice. At equatorial latitudes (and especially on dark terrains) the observed band is broader and shifted towards the blue, suggesting CO2 adsorbed on non-icy materials. Amorphous ice is detected in the ice-rich polar regions, and is especially abundant on the leading northern polar cap. In both hemispheres the north polar cap ice appears to be more processed than the south polar cap. A longitudinal modification of the H2O ice molecular structure and/or nano/micrometre-scale texture, of diurnal or geographic origin, is observed in both hemispheres. Ice frost is observed on the morning limb of the trailing hemisphere, possibly formed during the night from the recondensation of water subliming from the warmer subsurface. Reflectance spectra of the dark terrains are compatible with the presence of Na-/Mg-sulfate salts, sulfuric acid hydrates, and possibly phyllosilicates mixed with fine-grained opaque minerals, having an highly porous texture. Mid-IR brightness temperatures indicate a rough surface and a very low thermal inertia of 20-40 J m-2 s-0.5 K-1, consistent with a porous surface., Comment: 35 pages, 34 figures
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- 2023
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31. Unbiased Estimation of Structured Prediction Error
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Fry, Kevin and Taylor, Jonathan E.
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Statistics - Methodology - Abstract
Many modern datasets, such as those in ecology and geology, are composed of samples with spatial structure and dependence. With such data violating the usual independent and identically distributed (IID) assumption in machine learning and classical statistics, it is unclear a priori how one should measure the performance and generalization of models. Several authors have empirically investigated cross-validation (CV) methods in this setting, reaching mixed conclusions. We provide a class of unbiased estimation methods for general quadratic errors, correlated Gaussian response, and arbitrary prediction function $g$, for a noise-elevated version of the error. Our approach generalizes the coupled bootstrap (CB) from the normal means problem to general normal data, allowing correlation both within and between the training and test sets. CB relies on creating bootstrap samples that are intelligently decoupled, in the sense of being statistically independent. Specifically, the key to CB lies in generating two independent "views" of our data and using them as stand-ins for the usual independent training and test samples. Beginning with Mallows' $C_p$, we generalize the estimator to develop our generalized $C_p$ estimators (GC). We show at under only a moment condition on $g$, this noise-elevated error estimate converges smoothly to the noiseless error estimate. We show that when Stein's unbiased risk estimator (SURE) applies, GC converges to SURE as in the normal means problem. Further, we use these same tools to analyze CV and provide some theoretical analysis to help understand when CV will provide good estimates of error. Simulations align with our theoretical results, demonstrating the effectiveness of GC and illustrating the behavior of CV methods. Lastly, we apply our estimator to a model selection task on geothermal data in Nevada., Comment: 28 pages, 13 figures
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- 2023
32. Cognitive Tuning in the STEM Classroom: Communication Processes Supporting Children's Changing Conceptions about Data
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Kym Fry, Lyn English, and Katie Makar
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The teaching and learning of statistical thinking begins at a young age in Australia, with a focus on data representation and interpretation from Foundation Year (age 5), and the collection, sorting and categorising of items from the natural environment starting even earlier. The intangible concept of "data," as part of statistical literacy, can be complex for children to grasp, especially when applying the notion of data to the everyday world or when data are explored in isolation to an investigation process. Authentic data modelling experiences present meaningful opportunities to apply statistical thinking although expert STEM knowledge is not always accessible to primary classroom teachers, nor is it always obvious how to implement such authentic problems within a classroom context. In this exploratory case study, we present data from a Year 4 classroom (age 9) statistical investigation addressing, 'How big is a leaf?' linking data to the real-life STEM context they represented. The authors were interested in how the teacher's communication processes supported her students' emerging understandings about data. Wit's (2018) cognitive tuning framework offered a way to capture how the communication processes in a group build to a commonly shared frame of reference. Findings revealed a pattern of communication between the teacher and students, supporting students' changing conceptions of data and related statistical thinking processes, throughout the investigation.
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- 2024
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33. The Teaching of Introductory Statistics: Results of a National Survey
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Chelsey Legacy, Laura Le, Andrew Zieffler, Elizabeth Fry, and Pablo Vivas Corrales
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The "Statistics Teaching Inventory" (STI) was designed to assess the teaching practices of U.S.-based, college-level introductory statistics instructors in a variety of institutions and departments. This instrument has now been updated to reflect current trends and recommendations in statistics education. In this study, we used the STI to examine the current state of the curricular and instructional practices being used by U.S.-based, college-level introductory statistics instructors. We explore the extent to which instructors report that their introductory statistics courses are aligned with recommended practices as outlined by the 2016 GAISE College Report. Data were collected from a sample of college-level U.S.-based, college-level introductory statistics instructors. Results based on 228 usable responses indicated that instructors, by-and-large, tended to be following the GAISE recommendations, especially related to content. However, courses may not yet be aligned with newer content recommendations (e.g., provide students opportunities to work with multivariate data), and there is still a large percentage of instructors that are not embracing student-oriented pedagogies and assessment methods. Supplementary materials for this article are available online.
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- 2024
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34. Community tuberculosis screening, testing and care, Uganda/ Depistage, analyse et prise en charge de la tuberculose au niveau communautaire en Ouganda/Deteccion, pruebas y atencion de la tuberculosis a nivel comunitario en Uganda
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Turyahabwe, Stavia, Bamuloba, Muzamiru, Mugenyi, Levicatus, Amanya, Geoffrey, Byaruhanga, Raymond, Imoko, Joseph Fry, Nakawooya, Mabel, Walusimbi, Simon, Nidoi, Jasper, Burua, Aldomoro, Sekadde, Moorine, Muttamba, Winters, Arinaitwe, Moses, Henry, Luzze, Kengonzi, Rose, Mudiope, Mary, and Kirenga, Bruce J.
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Lepers -- Analysis ,Tuberculosis -- Analysis ,Contact tracing -- Analysis ,Leprosy -- Analysis ,Health ,World Health Organization - Abstract
Objective To assess the effectiveness of a community-based tuberculosis and leprosy intervention in which village health teams and health workers conduct door-to-door tuberculosis screening, targeted screenings and contact tracing. Methods We conducted a before-and-after implementation study in Uganda to assess the effectiveness of the community tuberculosis intervention by looking at reach, outputs, adoption and effectiveness of the intervention. Campaign 1 was conducted in March 2022 and campaign 2 in September 2022. We calculated percentages of targets achieved and compared case notification rates during the intervention with corresponding quarters in the previous year. We also assessed the leprosy screening. Findings Over 5 days, campaign 1 screened 1 289 213 people (2.9% of the general population), of whom 179 144 (13.9%) fulfilled the presumptive tuberculosis criteria, and 4043 (2.3%) were diagnosed with bacteriologically-confirmed tuberculosis; 3710 (91.8%) individuals were linked to care. In campaign 2, 5 134 056 people (11.6% of the general population) were screened, detecting 428 444 (8.3%) presumptive tuberculosis patients and 8121 (1.9%) bacteriologically-confirmed tuberculosis patients; 5942 individuals (87.1%) were linked to care. The case notification rate increased from 48.1 to 59.5 per 100 000 population in campaign 1, with a case notification rate ratio of 1.24 (95% confidence interval, CI: 1.22-1.26). In campaign 2, the case notification rate increased from 45.0 to 71.6 per 100 000 population, with a case notification rate ratio of 1.59 (95% CI: 1.56-1.62). Of the 176 patients identified with leprosy, 137 (77.8%) initiated treatment. Conclusion This community tuberculosis screening initiative is effective. However, continuous monitoring and adaptations are needed to overcome context-specific implementation challenges. Objectif Evaluer l'efficacite d'une intervention de lutte contre la tuberculose et la lepre au niveau communautaire, dans le cadre de laquelle des equipes et agents de sante du village effectuent un depistage en porte-a-porte, des analyses ciblees et un suivi des contacts. Methodes Nous avons mene une etude en Ouganda, avant et apres la mise en reuvre, afin de mesurer les performances de cette intervention communautaire en examinant sa portee, ses resultats, son adoption et son efficacite. La campagne 1 s'est deroulee en mars 2022 et la campagne 2 en septembre 2022. Nous avons calcule les pourcentages d'objectifs atteints et compare le taux de signalement des cas durant l'intervention avec les trimestres correspondants de l'annee precedente. Nous avons egalement evalue le depistage de la lepre. Resultats En l'espace de cinq jours, la campagne 1 a passe en revue 1 289 213 personnes (2,9% de la population generale); parmi elles, 179 144 (13,9%) remplissaient les criteres d'une tuberculose presumee, 4043 (2,3%) ont regu un diagnostic de tuberculose avec confirmation bacteriologique et 3710 (91,8%) ont fait l'objet d'un suivi medical. Lors de la campagne 2, 5 134 056 personnes (11,6% de la population generale) ont fait l'objet d'un depistage; 428 444 (8,3%) cas presumes de tuberculose ont ete detectes et 8121 (1,9%) d'entre eux ont regu une confirmation bacteriologique, tandis que 5942 individus (87,1%) ont fait l'objet d'un suivi medical. De son cote, le taux de signalement des cas a augmente, passant de 48,1 a 59,5 par 100 000 habitants durant la campagne 1, ce qui equivaut a un rapport de taux de 1,24 (intervalle de confiance (IC) de 95%: 1,22-1,26). Et durant la campagne 2, le taux de signalement des cas a progresse de 45,0 a 71,6 par 100 000 habitants, avec un rapport de taux de 1,59 (IC de 95%: 1,56-1,62). Sur les 176 patients caracterises par un diagnostic de lepre, 137 (77,8%) ont entame un traitement. Conclusion Cette initiative de depistage communautaire s'est revelee efficace. Il est cependant necessaire d'exercer une surveillance continue et de proceder a des adaptations pour surmonter les difficultes de mise en reuvre liees au contexte. Objetivo Evaluar la eficacia de una intervencion comunitaria contra la tuberculosis y la lepra en la que los equipos y los profesionales sanitarios de los pueblos realizan pruebas de deteccion de la tuberculosis puerta a puerta, pruebas de deteccion selectivas y rastreo de contactos. Metodos Se realizo un estudio de implementacion antes y despues en Uganda para evaluar la eficacia de la intervencion comunitaria contra la tuberculosis mediante el analisis del alcance, los resultados, la adopcion y la eficacia de la intervencion. La campana 1 se llevo a cabo en marzo de 2022 y la campana 2 en septiembre de 2022. Se calcularon los porcentajes de objetivos alcanzados y se compararon las tasas de notificacion de casos durante la intervencion con los trimestres correspondientes del ano anterior.Ademas, se evaluo la deteccion de la lepra. Resultados Durante cinco dias, en la campana 1, se sometio a cribado a 1 289 213 personas (el 2,9% de la poblacion general), de las cuales 179 144 (el 13,9%) cumplian los criterios de presuncion de tuberculosis y a 4043 (el 2,3%) se les diagnostico tuberculosis confirmada bacteriologicamente; 3710 (el 91,8%) personas recibieron asistencia. En la campana 2, se sometio a cribado a 5 134 056 personas (11,6% de la poblacion general), detectandose 428 444 (8,3%) pacientes con tuberculosis presunta y 8121 (1,9%) con tuberculosis confirmada bacteriologicamente; 5942 personas (87,1%) recibieron asistencia. La tasa de notificacion de casos aumento de 48,1 a 59,5 por 100 000 habitantes en la campana 1, con una razon de tasa de notificacion de casos de 1,24 (intervalo de confianza del 95%, IC: 1,22-1,26). En la campana 2, la tasa de notificacion de casos aumento de 45,0 a 71,6 por 100 000 habitantes, con una razon de tasa de notificacion de casos de 1,59 (IC del 95%: 1,56-1,62). De los 176 pacientes identificados con lepra, 137 (77,8%) iniciaron tratamiento. Conclusion Esta iniciativa comunitaria de deteccion de la tuberculosis es eficaz. Sin embargo, se necesita un seguimiento continuo y adaptaciones para superar los desafios de implementacion especificos del contexto., Introduction Tuberculosis remains one of the leading causes of death worldwide. (1) In 2022, approximately 10.6 million people fell sick with tuberculosis globally, with most cases occurring in South-East Asia [...]
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- 2024
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35. A preliminary characterization of the psychometric properties and generalizability of a novel social approach-avoidance paradigm
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Evans, Travis C., Carlson, Josie, Zuberer, Agnieszka, Fry, Regan, Agnoli, Sam, Britton, Jennifer C., DeGutis, Joseph, and Esterman, Michael
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- 2024
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36. Health-related quality of life at age 10 years in children born extremely preterm
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Call, Catherine, Oran, Ali, O’Shea, T. Michael, Jensen, Elizabeth T., Frazier, Jean A., Vaidya, Ruben, Shenberger, Jeffrey, Gogcu, Semsa, Msall, Michael E., Kim, Sohye, Jalnapurkar, Isha, Fry, Rebecca C., and Singh, Rachana
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- 2024
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37. Red-on-Yellow Queen: Bio-Layer Interferometry Reveals Functional Diversity Within Micrurus Venoms and Toxin Resistance in Prey Species
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Dashevsky, Daniel, Harris, Richard J., Zdenek, Christina N., Benard-Valle, Melisa, Alagón, Alejandro, Portes-Junior, José A., Tanaka-Azevedo, Anita M., Grego, Kathleen F., Sant’Anna, Sávio S., Frank, Nathaniel, and Fry, Bryan G.
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- 2024
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38. Impact of healthcare-associated infections within 7-days of acute stroke on health outcomes and risk of care-dependency: a multi-centre registry-based cohort study
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Fluck, David, Fry, Christopher H., Robin, Jonathan, Affley, Brendan, Kakar, Puneet, Sharma, Pankaj, and Han, Thang S.
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- 2024
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39. Continuous positive airway pressure compliance in patients with mild cognitive impairment
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Briand, Raphaël, Lebouvier, Thibaud, Lanvin, Lise, Ramdane, Nassima, Skrobala, Emilie, Leroy, Mélanie, Chenivesse, Cécile, Fry, Stéphanie, and Le Rouzic, Olivier
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- 2024
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40. Alliance for Scientific Autism Intervention: System Components and Outcome Data from High-Quality Service Delivery Organizations
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Townsend, Dawn Buffington, Brothers, Kevin J., MacDuff, Gregory S., Freeman, Amanda, Fry, Christine, Rozenblat, Eric, DeFeo, Donna, Budzinska, Anna, Ruta-Sominka, Iwona, Birkan, Binyamin, Hall, Laura J., Krantz, Patricia J., and McClannahan, Lynn E.
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- 2024
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41. Access, acceptance and adherence to cancer prehabilitation: a mixed-methods systematic review
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Watts, Tessa, Courtier, Nicholas, Fry, Sarah, Gale, Nichola, Gillen, Elizabeth, McCutchan, Grace, Patil, Manasi, Rees, Tracy, Roche, Dominic, Wheelwright, Sally, and Hopkinson, Jane
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- 2024
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42. Navigating the post-Dobbs landscape: ethical considerations from a perinatal perspective
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Pyle, Alaina, Adams, Shannon Y., Cortezzo, DonnaMaria E., Fry, Jessica T., Henner, Natalia, Laventhal, Naomi, Lin, Matthew, Sullivan, Kevin, and Wraight, C. Lydia
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- 2024
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43. Model-based financial regulations impair the transition to net-zero carbon emissions
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Gasparini, Matteo, Ives, Matthew C., Carr, Ben, Fry, Sophie, and Beinhocker, Eric
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- 2024
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44. Aristocrats in Arbitration: Did Class Affect Inter-state Arbitration Before or After the 1899 Hague Peace Conference?
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Fry, James D., Cheung, Arthur L. W., and Michael, Bryane
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- 2024
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45. Epigenetic Responses to Nonchemical Stressors: Potential Molecular Links to Perinatal Health Outcomes
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Eaves, Lauren A., Harrington, Cailee E., and Fry, Rebecca C.
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- 2024
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46. A Schema Conceptualisation of Psychosocial Functioning Among Transitioned Military Personnel
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Fry, Megan A., Boschen, Mark J., Morrissey, Shirley A., Yalcin, Ozgur, and Burton, Nicola W.
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- 2024
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47. Inhibition of p53-MDM2 binding reduces senescent cell abundance and improves the adaptive responses of skeletal muscle from aged mice
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Nolt, Georgia L., Keeble, Alexander R., Wen, Yuan, Strong, Aubrey C., Thomas, Nicholas T., Valentino, Taylor R., Brightwell, Camille R., Murach, Kevin A., Patrizia, Sini, Weinstabl, Harald, Gollner, Andreas, McCarthy, John J., Fry, Christopher S., Franti, Michael, Filareto, Antonio, Peterson, Charlotte A., and Dungan, Cory M.
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- 2024
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48. Scenario-robust pre-disaster planning for multiple relief items
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Yang, Muer, Kumar, Sameer, Wang, Xinfang, and Fry, Michael J.
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- 2024
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49. Gender and entrepreneurial intention in low-income countries: the relative roles played by anticipated financial returns versus perceived barriers for university students in Sierra Leone
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Bradley, Wendy A. and Fry, Caroline
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- 2024
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50. Galois automorphisms and a unique Jordan decomposition in the case of connected centralizer
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Fry, A. A. Schaeffer, Taylor, Jay, and Vinroot, C. Ryan
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Mathematics - Group Theory ,Mathematics - Representation Theory - Abstract
We show that the Jordan decomposition of characters of finite reductive groups can be chosen so that if the centralizer of the relevant semisimple element is connected, then the map is Galois-equivariant. Further, in this situation, we show that there is a unique Jordan decomposition satisfying conditions analogous to those of Digne--Michel's unique Jordan decomposition in the connected center case.
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- 2023
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