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1. Design and expected performance of the MICE demonstration of ionization cooling

Author

MICE Collaboration, Bogomilov, M., Tsenov, R., Vankova-Kirilova, G., Song, Y., Tang, J., Li, Z., Bertoni, R., Bonesini, M., Chignoli, F., Mazza, R., Palladino, V., de Bari, A., Cecchet, G., Orestano, D., Tortora, L., Kuno, Y., Ishimoto, S., Filthaut, F., Jokovic, D., Maletic, D., Savic, M., Hansen, O. M., Ramberger, S., Vretenar, M., Asfandiyarov, R., Blondel, A., Drielsma, F., Karadzhov, Y., Charnley, G., Collomb, N., Gallagher, A., Grant, A., Griffiths, S., Hartnett, T., Martlew, B., Moss, A., Muir, A., Mullacrane, I., Oates, A., Owens, P., Stokes, G., Tucker, M., Warburton, P., White, C., Adams, D., Anderson, R. J., Barclay, P., Bayliss, V., Boehm, J., Bradshaw, T. W., Courthold, M., Dumbell, K., Francis, V., Fry, L., Hayler, T., Hills, M., Lintern, A., Macwaters, C., Nichols, A., Preece, R., Ricciardi, S., Rogers, C., Stanley, T., Tarrant, J., Wilson, A., Watson, S., Bayes, R., Nugent, J. C., Soler, F. J. P., Gamet, R., Barber, G., Blackmore, V. J., Colling, D., Dobbs, A., Dornan, P., Hunt, C., Kurup, A., Lagrange, J-B., Long, K., Martyniak, J., Middleton, S., Pasternak, J., Uchida, M. A., Cobb, J. H., Lau, W., Booth, C. N., Hodgson, P., Langlands, J., Overton, E., Robinson, M., Smith, P. J., Wilbur, S., Dick, A. J., Ronald, K., Whyte, C. G., Young, A. R., Boyd, S., Franchini, P., Greis, J. R., Pidcott, C., Taylor, I., Gardener, R. B. S., Kyberd, P., Nebrensky, J. J., Palmer, M., Witte, H., Bross, A. D., Bowring, D., Liu, A., Neuffer, D., Popovic, M., Rubinov, P., DeMello, A., Gourlay, S., Li, D., Prestemon, S., Virostek, S., Freemire, B., Hanlet, P., Kaplan, D. M., Mohayai, T. A., Rajaram, D., Snopok, P., Suezaki, V., Torun, Y., Onel, Y., Cremaldi, L. M., Sanders, D. A., Summers, D. J., Hanson, G. G., and Heidt, C.

Subjects
Physics - Accelerator Physics
Abstract

Muon beams of low emittance provide the basis for the intense, well-characterised neutrino beams necessary to elucidate the physics of flavour at a neutrino factory and to provide lepton-antilepton collisions at energies of up to several TeV at a muon collider. The international Muon Ionization Cooling Experiment (MICE) aims to demonstrate ionization cooling, the technique by which it is proposed to reduce the phase-space volume occupied by the muon beam at such facilities. In an ionization-cooling channel, the muon beam passes through a material in which it loses energy. The energy lost is then replaced using RF cavities. The combined effect of energy loss and re-acceleration is to reduce the transverse emittance of the beam (transverse cooling). A major revision of the scope of the project was carried out over the summer of 2014. The revised experiment can deliver a demonstration of ionization cooling. The design of the cooling demonstration experiment will be described together with its predicted cooling performance., Comment: 21 pages, 10 figures

Published
2017
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2. Lattice design and expected performance of the Muon Ionization Cooling Experiment demonstration of ionization cooling

Author

Bogomilov, M, Tsenov, R, Vankova-Kirilova, G, Song, Y, Tang, J, Li, Z, Bertoni, R, Bonesini, M, Chignoli, F, Mazza, R, Palladino, V, De Bari, A, Cecchet, G, Orestano, D, Tortora, L, Kuno, Y, Ishimoto, S, Filthaut, F, Jokovic, D, Maletic, D, Savic, M, Hansen, OM, Ramberger, S, Vretenar, M, Asfandiyarov, R, Blondel, A, Drielsma, F, Karadzhov, Y, Charnley, G, Collomb, N, Dumbell, K, Gallagher, A, Grant, A, Griffiths, S, Hartnett, T, Martlew, B, Moss, A, Muir, A, Mullacrane, I, Oates, A, Owens, P, Stokes, G, Warburton, P, White, C, Adams, D, Anderson, RJ, Barclay, P, Bayliss, V, Boehm, J, Bradshaw, TW, Courthold, M, Francis, V, Fry, L, Hayler, T, Hills, M, Lintern, A, Macwaters, C, Nichols, A, Preece, R, Ricciardi, S, Rogers, C, Stanley, T, Tarrant, J, Tucker, M, Wilson, A, Watson, S, Bayes, R, Nugent, JC, Soler, FJP, Gamet, R, Barber, G, Blackmore, VJ, Colling, D, Dobbs, A, Dornan, P, Hunt, C, Kurup, A, Lagrange, JB, Long, K, Martyniak, J, Middleton, S, Pasternak, J, Uchida, MA, Cobb, JH, Lau, W, Booth, CN, Hodgson, P, Langlands, J, Overton, E, Robinson, M, Smith, PJ, Wilbur, S, Dick, AJ, Ronald, K, Whyte, CG, Young, AR, Boyd, S, Franchini, P, Greis, JR, and Pidcott, C

Subjects
physics.acc-ph
Abstract

Muon beams of low emittance provide the basis for the intense, well-characterized neutrino beams necessary to elucidate the physics of flavor at a neutrino factory and to provide lepton-antilepton collisions at energies of up to several TeV at a muon collider. The international Muon Ionization Cooling Experiment (MICE) aims to demonstrate ionization cooling, the technique by which it is proposed to reduce the phase-space volume occupied by the muon beam at such facilities. In an ionization-cooling channel, the muon beam passes through a material in which it loses energy. The energy lost is then replaced using rf cavities. The combined effect of energy loss and reacceleration is to reduce the transverse emittance of the beam (transverse cooling). A major revision of the scope of the project was carried out over the summer of 2014. The revised experiment can deliver a demonstration of ionization cooling. The design of the cooling demonstration experiment will be described together with its predicted cooling performance.

Published
2017

3. Pion contamination in the MICE muon beam

Author

Adams, D., Alekou, A., Apollonio, M., Asfandiyarov, R., Barber, G., Barclay, P., de Bari, A., Bayes, R., Bayliss, V., Bertoni, R., Blackmore, V. J., Blondel, A., Blot, S., Bogomilov, M., Bonesini, M., Booth, C. N., Bowring, D., Boyd, S., Bradshaw, T. W., Bravar, U., Bross, A. D., Capponi, M., Carlisle, T., Cecchet, G., Charnley, C., Chignoli, F., Cline, D., Cobb, J. H., Colling, G., Collomb, N., Coney, L., Cooke, P., Courthold, M., Cremaldi, L. M., DeMello, A., Dick, A., Dobbs, A., Dornan, P., Drews, M., Drielsma, F., Filthaut, F., Fitzpatrick, T., Franchini, P., Francis, V., Fry, L., Gallagher, A., Gamet, R., Gardener, R., Gourlay, S., Grant, A., Greis, J. R., Griffiths, S., Hanlet, P., Hansen, O. M., Hanson, G. G., Hart, T. L., Hartnett, T., Hayler, T., Heidt, C., Hills, M., Hodgson, P., Hunt, C., Iaciofano, A., Ishimoto, S., Kafka, G., Kaplan, D. M., Karadzhov, Y., Kim, Y. K., Kuno, Y., Kyberd, P., Lagrange, J-B, Langlands, J., Lau, W., Leonova, M., Li, D., Lintern, A., Littlefield, M., Long, K., Luo, T., Macwaters, C., Martlew, B., Martyniak, J., Mazza, R., Middleton, S., Moretti, A., Moss, A., Muir, A., Mullacrane, I., Nebrensky, J. J., Neuffer, D., Nichols, A., Nicholson, R., Nugent, J. C., Oates, A., Onel, Y., Orestano, D., Overton, E., Owens, P., Palladino, V., Pasternak, J., Pastore, F., Pidcott, C., Popovic, M., Preece, R., Prestemon, S., Rajaram, D., Ramberger, S., Rayner, M. A., Ricciardi, S., Roberts, T. J., Robinson, M., Rogers, C., Ronald, K., Rubinov, P., Rucinski, P., Sakamato, H., Sanders, D. A., Santos, E., Savidge, T., Smith, P. J., Snopok, P., Soler, F. J. P., Speirs, D., Stanley, T., Stokes, G., Summers, D. J., Tarrant, J., Taylor, I., Tortora, L., Torun, Y., Tsenov, R., Tunnell, C. D., Uchida, M. A., Vankova-Kirilova, G., Virostek, S., Vretenar, M., Warburton, P., Watson, S., White, C., Whyte, C. G., Wilson, A., Winter, M., Yang, X., Young, A., and Zisman, M.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

The international Muon Ionization Cooling Experiment (MICE) will perform a systematic investigation of ionization cooling with muon beams of momentum between 140 and 240\,MeV/c at the Rutherford Appleton Laboratory ISIS facility. The measurement of ionization cooling in MICE relies on the selection of a pure sample of muons that traverse the experiment. To make this selection, the MICE Muon Beam is designed to deliver a beam of muons with less than $\sim$1\% contamination. To make the final muon selection, MICE employs a particle-identification (PID) system upstream and downstream of the cooling cell. The PID system includes time-of-flight hodoscopes, threshold-Cherenkov counters and calorimetry. The upper limit for the pion contamination measured in this paper is $f_\pi < 1.4\%$ at 90\% C.L., including systematic uncertainties. Therefore, the MICE Muon Beam is able to meet the stringent pion-contamination requirements of the study of ionization cooling., Comment: 16 pages, 7 figures

Published
2015
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4. Electron-Muon Ranger: performance in the MICE Muon Beam

Author

Adams, D., Alekou, A., Apollonio, M., Asfandiyarov, R., Barber, G., Barclay, P., de Bari, A., Bayes, R., Bayliss, V., Bene, P., Bertoni, R., Blackmore, V. J., Blondel, A., Blot, S., Bogomilov, M., Bonesini, M., Booth, C. N., Bowring, D., Boyd, S., Bradshaw, T. W., Bravar, U., Bross, A. D., Cadoux, F., Capponi, M., Carlisle, T., Cecchet, G., Charnley, C., Chignoli, F., Cline, D., Cobb, J. H., Colling, G., Collomb, N., Coney, L., Cooke, P., Courthold, M., Cremaldi, L. M., Debieux, S., DeMello, A., Dick, A., Dobbs, A., Dornan, P., Drielsma, F., Filthaut, F., Fitzpatrick, T., Franchini, P., Francis, V., Fry, L., Gallagher, A., Gamet, R., Gardener, R., Gourlay, S., Grant, A., Graulich, J. S., Greis, J., Griffiths, S., Hanlet, P., Hansen, O. M., Hanson, G. G., Hart, T. L., Hartnett, T., Hayler, T., Heidt, C., Hills, M., Hodgson, P., Hunt, C., Husi, C., Iaciofano, A., Ishimoto, S., Kafka, G., Kaplan, D. M., Karadzhov, Y., Kim, Y. K., Kuno, Y., Kyberd, P., Lagrange, J-B, Langlands, J., Lau, W., Leonova, M., Li, D., Lintern, A., Littlefield, M., Long, K., Luo, T., Macwaters, C., Martlew, B., Martyniak, J., Masciocchi, F., Mazza, R., Middleton, S., Moretti, A., Moss, A., Muir, A., Mullacrane, I., Nebrensky, J. J., Neuffer, D., Nichols, A., Nicholson, R., Nicola, L., Messomo, E. Noah, Nugent, J. C., Oates, A., Onel, Y., Orestano, D., Overton, E., Owens, P., Palladino, V., Pasternak, J., Pastore, F., Pidcott, C., Popovic, M., Preece, R., Prestemon, S., Rajaram, D., Ramberger, S., Rayner, M. A., Ricciardi, S., Roberts, T. J., Robinson, M., Rogers, C., Ronald, K., Rothenfusser, K., Rubinov, P., Rucinski, P., Sakamato, H., Sanders, D. A., Sandstrom, R., Santos, E., Savidge, T., Smith, P. J., Snopok, P., Soler, F. J. P., Speirs, D., Stanley, T., Stokes, G., Summers, D. J., Tarrant, J., Taylor, I., Tortora, L., Torun, Y., Tsenov, R., Tunnell, C. D., Uchida, M. A., Vankova-Kirilova, G., Virostek, S., Vretenar, M., Warburton, P., Watson, S., White, C., Whyte, C. G., Wilson, A., Wisting, H., Yang, X., Young, A., and Zisman, M.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

The Muon Ionization Cooling Experiment (MICE) will perform a detailed study of ionization cooling to evaluate the feasibility of the technique. To carry out this program, MICE requires an efficient particle-identification (PID) system to identify muons. The Electron-Muon Ranger (EMR) is a fully-active tracking-calorimeter that forms part of the PID system and tags muons that traverse the cooling channel without decaying. The detector is capable of identifying electrons with an efficiency of 98.6%, providing a purity for the MICE beam that exceeds 99.8%. The EMR also proved to be a powerful tool for the reconstruction of muon momenta in the range 100-280 MeV/$c$., Comment: 22 pages, 19 figures

Published
2015
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5. Pion contamination in the MICE muon beam

Author

Adams, D, Alekou, A, Apollonio, M, Asfandiyarov, R, Barber, G, Barclay, P, de Bari, A, Bayes, R, Bayliss, V, Bertoni, R, Blackmore, VJ, Blondel, A, Blot, S, Bogomilov, M, Bonesini, M, Booth, CN, Bowring, D, Boyd, S, Brashaw, TW, Bravar, U, Bross, AD, Capponi, M, Carlisle, T, Cecchet, G, Charnley, C, Chignoli, F, Cline, D, Cobb, JH, Colling, G, Collomb, N, Coney, L, Cooke, P, Courthold, M, Cremaldi, LM, DeMello, A, Dick, A, Dobbs, A, Dornan, P, Drews, M, Drielsma, F, Filthaut, F, Fitzpatrick, T, Franchini, P, Francis, V, Fry, L, Gallagher, A, Gamet, R, Gardener, R, Gourlay, S, Grant, A, Greis, JR, Griffiths, S, Hanlet, P, Hansen, OM, Hanson, GG, Hart, TL, Hartnett, T, Hayler, T, Heidt, C, Hills, M, Hodgson, P, Hunt, C, Iaciofano, A, Ishimoto, S, Kafka, G, Kaplan, DM, Karadzhov, Y, Kim, YK, Kuno, Y, Kyberd, P, Lagrange, J-B, Langlands, J, Lau, W, Leonova, M, Li, D, Lintern, A, Littlefield, M, Long, K, Luo, T, Macwaters, C, Martlew, B, Martyniak, J, Mazza, R, Middleton, S, Moretti, A, Moss, A, Muir, A, Mullacrane, I, Nebrensky, JJ, Neuffer, D, Nichols, A, Nicholson, R, Nugent, JC, Oates, A, Onel, Y, Orestano, D, Overton, E, Owens, P, Palladino, V, and Pasternak, J

Subjects
Nuclear and Plasma Physics, Particle and High Energy Physics, Synchrotrons and Accelerators, Physical Sciences, Instrumentation for particle accelerators and storage rings - low energy, Beam-line instrumentation (beam position and profile, monitors, beam-intensity monitors, bunch length monitors), physics.ins-det, hep-ex, Engineering, Nuclear & Particles Physics, Physical sciences
Abstract

The international Muon Ionization Cooling Experiment (MICE) will perform a systematic investigation of ionization cooling with muon beams of momentum between 140 and 240 MeV/c at the Rutherford Appleton Laboratory ISIS facility. The measurement of ionization cooling in MICE relies on the selection of a pure sample of muons that traverse the experiment. To make this selection, the MICE Muon Beam is designed to deliver a beam of muons with less than ∼1% contamination. To make the final muon selection, MICE employs a particle-identification (PID) system upstream and downstream of the cooling cell. The PID system includes time-of-flight hodoscopes, threshold-Cherenkov counters and calorimetry. The upper limit for the pion contamination measured in this paper is fπ < 1.4% at 90% C.L., including systematic uncertainties. Therefore, the MICE Muon Beam is able to meet the stringent pion-contamination requirements of the study of ionization cooling.

Published
2016

6. Electron-muon ranger: Performance in the MICE muon beam

Author

Adams, D, Alekou, A, Apollonio, M, Asfandiyarov, R, Barber, G, Barclay, P, De Bari, A, Bayes, R, Bayliss, V, Bene, P, Bertoni, R, Blackmore, VJ, Blondel, A, Blot, S, Bogomilov, M, Bonesini, M, Booth, CN, Bowring, D, Boyd, S, Bradshaw, TW, Bravar, U, Bross, AD, Cadoux, F, Capponi, M, Carlisle, T, Cecchet, G, Charnley, C, Chignoli, F, Cline, D, Cobb, JH, Colling, G, Collomb, N, Coney, L, Cooke, P, Courthold, M, Cremaldi, LM, Debieux, S, Demello, A, Dick, A, Dobbs, A, Dornan, P, Drielsma, F, Filthaut, F, Fitzpatrick, T, Franchini, P, Francis, V, Fry, L, Gallagher, A, Gamet, R, Gardener, R, Gourlay, S, Grant, A, Graulich, JS, Greis, J, Griffiths, S, Hanlet, P, Hansen, OM, Hanson, GG, Hart, TL, Hartnett, T, Hayler, T, Heidt, C, Hills, M, Hodgson, P, Hunt, C, Husi, C, Iaciofano, A, Ishimoto, S, Kafka, G, Kaplan, DM, Karadzhov, Y, Kim, YK, Kuno, Y, Kyberd, P, Lagrange, JB, Langlands, J, Lau, W, Leonova, M, Li, D, Lintern, A, Littlefield, M, Long, K, Luo, T, Macwaters, C, Martlew, B, Martyniak, J, Masciocchi, F, Mazza, R, Middleton, S, Moretti, A, Moss, A, Muir, A, Mullacrane, I, Nebrensky, JJ, Neuffer, D, Nichols, A, Nicholson, R, Nicola, L, Messomo, EN, and Nugent, JC

Subjects
Particle identification methods, Particle tracking detectors, Performance of High Energy Physics Detectors, Calorimeters, physics.ins-det, hep-ex, Nuclear & Particles Physics, Other Physical Sciences, Physical Sciences, Engineering
Abstract

The Muon Ionization Cooling Experiment (MICE) will perform a detailed study of ionization cooling to evaluate the feasibility of the technique. To carry out this program, MICE requires an efficient particle-identification (PID) system to identify muons. The Electron-Muon Ranger (EMR) is a fully-active tracking-calorimeter that forms part of the PID system and tags muons that traverse the cooling channel without decaying. The detector is capable of identifying electrons with an efficiency of 98.6%, providing a purity for the MICE beam that exceeds 99.8%. The EMR also proved to be a powerful tool for the reconstruction of muon momenta in the range 100-280 MeV/c.

Published
2015

7. Characterisation of the muon beams for the Muon Ionisation Cooling Experiment

Author

The MICE Collaboration, Adams, D., Adey, D., Alekou, A., Apollonio, M., Asfandiyarov, R., Back, J., Barber, G., Barclay, P., de Bari, A., Bayes, R., Bayliss, V., Bertoni, R., Blackmore, V. J., Blondel, A., Blot, S., Bogomilov, M., Bonesini, M., Booth, C. N., Bowring, D., Boyd, S., Bradshaw, T. W., Bravar, U., Bross, A. D., Capponi, M., Carlisle, T., Cecchet, G., Charnley, G., Cobb, J. H., Colling, D., Collomb, N., Coney, L., Cooke, P., Courthold, M., Cremaldi, L. M., DeMello, A., Dick, A., Dobbs, A., Dornan, P., Fayer, S., Filthaut, F., Fish, A., Fitzpatrick, T., Fletcher, R., Forrest, D., Francis, V., Freemire, B., Fry, L., Gallagher, A., Gamet, R., Gourlay, S., Grant, A., Graulich, J. S., Griffiths, S., Hanlet, P., Hansen, O. M., Hanson, G. G., Harrison, P., Hart, T. L., Hartnett, T., Hayler, T., Heidt, C., Hills, M., Hodgson, P., Iaciofano, A., Ishimoto, S., Kafka, G., Kaplan, D. M., Karadzhov, Y., Kim, Y. K., Kolev, D., Kuno, Y., Kyberd, P., Lau, W., Leaver, J., Leonova, M., Li, D., Lintern, A., Littlefield, M., Long, K., Lucchini, G., Luo, T., Macwaters, C., Martlew, B., Martyniak, J., Moretti, A., Moss, A., Muir, A., Mullacrane, I., Nebrensky, J. J., Neuffer, D., Nichols, A., Nicholson, R., Nugent, J. C., Onel, Y., Orestano, D., Overton, E., Owens, P., Palladino, V., Pasternak, J., Pastore, F., Pidcott, C., Popovic, M., Preece, R., Prestemon, S., Rajaram, D., Ramberger, S., Rayner, M. A., Ricciardi, S., Richards, A., Roberts, T. J., Robinson, M., Rogers, C., Ronald, K., Rubinov, P., Rucinski, R., Rusinov, I., Sakamoto, H., Sanders, D. A., Santos, E., Savidge, T., Smith, P. J., Snopok, P., Soler, F. J. P., Stanley, T., Summers, D. J., Takahashi, M., Tarrant, J., Taylor, I., Tortora, L., Torun, Y., Tsenov, R., Tunnell, C. D., Vankova, G., Verguilov, V., Virostek, S., Vretenar, M., Walaron, K., Watson, S., White, C., Whyte, C. G., Wilson, A., Wisting, H., and Zisman, M.

Subjects
Physics - Accelerator Physics
Abstract

A novel single-particle technique to measure emittance has been developed and used to characterise seventeen different muon beams for the Muon Ionisation Cooling Experiment (MICE). The muon beams, whose mean momenta vary from 171 to 281 MeV/c, have emittances of approximately 1.5--2.3 \pi mm-rad horizontally and 0.6--1.0 \pi mm-rad vertically, a horizontal dispersion of 90--190 mm and momentum spreads of about 25 MeV/c. There is reasonable agreement between the measured parameters of the beams and the results of simulations. The beams are found to meet the requirements of MICE., Comment: Published in EPJC, 20 pages, 15 figures

Published
2013
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8. Cell separation and cryopreservation of cord blood fractions for immunotherapeutic applications

Author

Fry, L. J.

Subjects
362.17
Abstract

In 2008 Anthony Nolan opened the UK’s first public umbilical cord blood (CB) bank (Anthony Nolan Cell Therapy Centre, ANCTC) in which CB is stored for haematopoietic stem cell (HSC) transplantation. Due to strict quality thresholds, the majority of units are not suitable for transplantation. Therefore, ANCTC aims to create a Biobank allowing these units to be stored for other purposes. To ensure cell products retained high levels of viability and potency, this study optimised banking processes starting with assessing the effects of transport conditions. It is essential that units are of the highest possible quality upon arrival at ANCTC, yet there is no consensus as to the optimal transport conditions of HSCs. Therefore, different fresh storage temperatures and the effect of delaying cryopreservation was assessed on three sources of HSCs. Cells were found to be better maintained at refrigerated temperatures and to avoid significant losses in potency, delays in cryopreservation should be minimised to <24 hours for bone marrow and <48 hours for CB and mobilised peripheral blood stem cells. Based upon these observations, ANCTC maintains all fresh samples at refrigerated temperatures and aims to cryopreserve them within 24 hours of collection. Banking cells involves cryopreservation and potentially long term storage of samples, however, suboptimal cryopreservation conditions can result in reduced cell viability. Cryoprotectants are used to reduce damage during the freeze and thaw stages of cryopreservation but they have been linked to toxic effects observed in cells. Dimethyl sulphoxide (DMSO) was found to exhibit a dose-dependent toxic effect on CB and optimal concentrations were found to be between 7.5% and 10% (v/v). This study also highlights the importance of minimising exposure to DMSO to <1hour prior to freezing and <30 minutes post-thaw. In addition, the presence of 1% (w/v) dextran-40 in the cryoprotective solution was found to be crucial to maintaining cell potency. The Biobank would require the storage of specific pure cell populations. Tregs are vital for the homeostasis of the immune system and have the potential to be used therapeutically in autoimmunity or transplantation, thus making these cells an ideal candidate for the Biobank. CB Tregs were found to have reduced suppressive abilities compared to their adult counterparts, due to lower levels of FoxP3 intensity and CD39 expression. However, their higher frequency and a more defined CD25+ population facilitates the isolation process. Two banking strategies were assessed, using both research and GMP grade methods. Firstly banking an isolated pure Treg population which, post-thaw, the cells maintained their phenotype but viability and suppressive ability was reduced. Alternatively, mononuclear cells were banked and Tregs isolated post-thaw. This strategy resulted in comparable isolation yields and purities compared to fresh cells, however, improved viabilities and higher suppressive abilities were observed compared to the cryopreserved pure Treg samples (p=0.0012). Therefore, this banking strategy was found to be more efficient. Overall, this study has optimised banking procedures from the transport of fresh samples to isolation and cryopreservation of pure cell populations. Therefore, this study has laid the foundations for the creation of a Biobank within the ANCTC allowing the distribution of cell products not only for research purposes, but also potentially for their use in immunotherapeutic interventions.

Published
2014

9. Characterisation of the muon beams for the Muon Ionisation Cooling Experiment

Author

Adams, D, Adey, D, Alekou, A, Apollonio, M, Asfandiyarov, R, Back, J, Barber, G, Barclay, P, de Bari, A, Bayes, R, Bayliss, V, Bertoni, R, Blackmore, VJ, Blondel, A, Blot, S, Bogomilov, M, Bonesini, M, Booth, CN, Bowring, D, Boyd, S, Bradshaw, TW, Bravar, U, Bross, AD, Capponi, M, Carlisle, T, Cecchet, G, Charnley, G, Cobb, JH, Colling, D, Collomb, N, Coney, L, Cooke, P, Courthold, M, Cremaldi, LM, DeMello, A, Dick, AJ, Dobbs, A, Dornan, P, Fayer, S, Filthaut, F, Fish, A, Fitzpatrick, T, Fletcher, R, Forrest, D, Francis, V, Freemire, B, Fry, L, Gallagher, A, Gamet, R, Gourlay, S, Grant, A, Graulich, JS, Griffiths, S, Hanlet, P, Hansen, OM, Hanson, GG, Harrison, P, Hart, TL, Hartnett, T, Hayler, T, Heidt, C, Hills, M, Hodgson, P, Hunt, C, Iaciofano, A, Ishimoto, S, Kafka, G, Kaplan, DM, Karadzhov, Y, Kim, YK, Kolev, D, Kuno, Y, Kyberd, P, Lau, W, Leaver, J, Leonova, M, Li, D, Lintern, A, Littlefield, M, Long, K, Lucchini, G, Luo, T, Macwaters, C, Martlew, B, Martyniak, J, Middleton, S, Moretti, A, Moss, A, Muir, A, Mullacrane, I, Nebrensky, JJ, Neuffer, D, Nichols, A, Nicholson, R, Nugent, JC, Onel, Y, Orestano, D, Overton, E, Owens, P, and Palladino, V

Subjects
physics.acc-ph, Nuclear & Particles Physics, Quantum Physics, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Atomic, Molecular, Nuclear, Particle and Plasma Physics
Abstract

A novel single-particle technique to measure emittance has been developed and used to characterise seventeen different muon beams for the Muon Ionisation Cooling Experiment (MICE). The muon beams, whose mean momenta vary from 171 to 281 MeV/c, have emittances of approximately 1.2-2.3 π mm-rad horizontally and 0.6-1.0 π mm-rad vertically, a horizontal dispersion of 90-190 mm and momentum spreads of about 25 MeV/c. There is reasonable agreement between the measured parameters of the beams and the results of simulations. The beams are found to meet the requirements of MICE. © 2013 The Author(s).

Published
2013

26. P-017 Triple therapy versus dual antiplatelet therapy for dolichoectatic vertebrobasilar fusiform aneurysms treated with flow-diverters: the last frontier?

Author

Siddiqui, A, primary, Monteiro, A, additional, Hanel, R, additional, Kan, P, additional, Mohanty, A, additional, Cortez, G, additional, Rabinovich, M, additional, Matouk, C, additional, Sujijantarat, N, additional, Ebersole, K, additional, Fry, L, additional, Natarajan, S, additional, Owusu-Adjei, B, additional, Ortega-Gutierrez, S, additional, Vivanco-Suarez, J, additional, Wakhloo, A, additional, and Levy, E, additional

Published
2022
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27. The Great Lakes Runoff Intercomparison Project Phase 4: the Great Lakes (GRIP-GL)

Author

Mai, J., Shen, H. R., Tolson, B. A., Gaborit, E., Arsenault, R., Craig, J. R., Fortin, V., Fry, L. M., Gauch, M., Klotz, D., Kratzert, F., O'Brien, N., Princz, D. G., Koya, S. R., Roy, T., Seglenieks, F., Shrestha, N. K., Temgoua, A. G. T., Vionnet, V., Waddell, J. W., Mai, J., Shen, H. R., Tolson, B. A., Gaborit, E., Arsenault, R., Craig, J. R., Fortin, V., Fry, L. M., Gauch, M., Klotz, D., Kratzert, F., O'Brien, N., Princz, D. G., Koya, S. R., Roy, T., Seglenieks, F., Shrestha, N. K., Temgoua, A. G. T., Vionnet, V., and Waddell, J. W.

Abstract

Model intercomparison studies are carried out to test and compare the simulated outputs of various model setups over the same study domain. The Great Lakes region is such a domain of high public interest as it not only resembles a challenging region to model with its transboundary location, strong lake effects, and regions of strong human impact but is also one of the most densely populated areas in the USA and Canada. This study brought together a wide range of researchers setting up their models of choice in a highly standardized experimental setup using the same geophysical datasets, forcings, common routing product, and locations of performance evaluation across the 1×106 km2 study domain. The study comprises 13 models covering a wide range of model types from machine-learning-based, basin-wise, subbasin-based, and gridded models that are either locally or globally calibrated or calibrated for one of each of the six predefined regions of the watershed. Unlike most hydrologically focused model intercomparisons, this study not only compares models regarding their capability to simulate streamflow (Q) but also evaluates the quality of simulated actual evapotranspiration (AET), surface soil moisture (SSM), and snow water equivalent (SWE). The latter three outputs are compared against gridded reference datasets. The comparisons are performed in two ways – either by aggregating model outputs and the reference to basin level or by regridding all model outputs to the reference grid and comparing the model simulations at each grid-cell. The main results of this study are as follows: The comparison of models regarding streamflow reveals the superior quality of the machine-learning-based model in the performance of all experiments; even for the most challenging spatiotemporal validation, the machine learning (ML) model outperforms any other physically based model. While the locally calibrated models lead to good performance in calibration and temporal validation (even outp

Published
2022

28. Safety and effectiveness of a glistening-free single-piece hydrophobic acrylic intraocular lens (enVista)

Author

Packer M, Fry L, Lavery KT, Lehmann R, McDonald J, Nichamin L, Bearie B, Hayashida J, Altmann GE, and Khodai O

Subjects
Ophthalmology, RE1-994
Abstract

Mark Packer,1 Luther Fry,2 Kevin T Lavery,3 Robert Lehmann,4 James McDonald,5 Louis Nichamin,6 Brian Bearie,7,† Jon Hayashida,8 Griffith E Altmann,8 Omid Khodai8 1Department of Ophthalmology, Oregon Health and Science University, Eugene, OR, USA; 2University of Kansas Medical Center, Kansas City, KS, USA; 3Wayne State University, Detroit, MI, USA; 4Baylor College of Medicine, Houston, TX, USA; 5University of Arkansas for Medical Sciences, Little Rock, AR, USA; 6Laurel Eye Clinic, Brookville, PA, USA; 7Grand Rapids Eye Institute, Grand Rapids, MI, USA; 8Bausch & Lomb, Aliso Viejo, CA, USA †Brian Bearie passed away on March 9, 2011 Purpose: To evaluate the safety and effectiveness of a single-piece hydrophobic acrylic intraocular lens (IOL; enVista model MX60; Bausch & Lomb, Rochester, NY, USA) when used to correct aphakia following cataract extraction in adults. Methods: This was a prospective case series (NCT01230060) conducted in private practices in the US. Eligible subjects were adult patients with age-related cataract amenable to treatment with standard phacoemulsification/extracapsular cataract extraction. With follow-up of 6 months, primary safety and effectiveness end points included the rates of US Food and Drug Administration (FDA)-defined cumulative and persistent adverse events and the percentage of subjects who achieved best-corrected visual acuity (BCVA) of 20/40 or better at final visit. To evaluate rotational stability, subjects were randomized (1:1:1:1) to have the lens implanted in one of four axis positions in 45° increments. Results: A total of 122 subjects were enrolled. The rate of cumulative and persistent adverse events did not significantly exceed historical controls, as per FDA draft guidance. At the final postoperative visit, all subjects (100%) achieved a BCVA of 20/40 compared with the FDA historical control of 96.7%. Rotation of the IOL between the two final follow-up visits was ≤5° for 100% of eyes, and refractive stability was demonstrated. A low evaluation of posterior capsule opacification score was demonstrated, and no glistenings of any grade were reported for any subject at any visit. Conclusion: This study demonstrated the safety and effectiveness of the MX60 IOL. Favorable clinical outcomes included preserved BCVA, excellent rotational and refractive stability, no glistenings, and a low evaluation of posterior capsule opacification score. Keywords: cataract surgery, enVista, glistenings, intraocular lens, hydrophobic acrylic

Published
2013

32. Prospective multicentre study on antimicrobial resistance of Helicobacter pylori in Germany

Author

Wüppenhorst, Nicole, Draeger, Sarah, Stüger, Hans Peter, Hobmaier, Beate, Vorreiter, Jolanta, Kist, Manfred, Glocker, Erik-Oliver, Albert, F., Blenk, H., de Bär, G. Marquez, Eigner, U., Hillert, H., Hülsmann, H., Käflein, R., Keksel, O., Lerner, J., Lindner, M., Loddersteadt, G., Schneider, C., Schwede, I., Stachon, A., Tammer, I., Zimmer, M., Abels, W., Adolphs, J., Andree, H., Asbach, M., Auberle, T., Bauer, T., Bergenthal, D., Berger, H., Breja, R., De Weerth, A., Dischler, R., Dörflinger, G., Engel, M., Ernst, H., Erlenmaier, U., Falk, M., Fall, J., Ferentzi, C., Fleischer, E., Frühauf, S., Fry, L., Göbel, U., Greulich, P., Gronemeyer, R., Haferland, C., Hampel, M., Heitlage, G., Hörner, M., Huber, M., Janowitz, P., Kellner, H., Klemm, W., Kluge, F., Knapp, B., Konturek, P., Kröger, T., Küppers, B., Labenz, J., Mocny, M., Müller, T., Oehler, R., Peitz, U., Pfäffl, S., Schiffelholz, W., Scholz, S., Schumacher, R., Stiebens, A., Strobel, M., Usadel, H., Votteler, B., Wallgrün, N., Wallstabe, I., Wegener, W., Wilhelm, K., Wilke, W., Zeus, J., Zwack, K., Heep, Markus, Vetter-Knoll, Marianne, Wolf, Bärbel, and Zwilling, Andrea

Published
2014
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