92,464 results on '"Fry, A."'
Search Results
2. RingSim- An Agent-based Approach for Modelling Mesoscopic Magnetic Nanowire Networks
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Vidamour, Ian T, Venkat, Guru, Swindells, Charles, Griffin, David, Fry, Paul W, Rowan-Robinson, Richard M, Welbourne, Alexander, Maccherozzi, Francesco, Dhesi, Sarnjeet S, Stepney, Susan, Allwood, Dan A, and Hayward, Thomas J
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Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
We describe 'RingSim', a phenomenological agent-based model that allows numerical simulation of magnetic nanowire networks with areas of hundreds of micrometers squared for durations of hundreds of seconds; a practical impossibility for general-purpose micromagnetic simulation tools. In RingSim, domain walls (DWs) are instanced as mobile agents which respond to external magnetic fields, and their stochastic interactions with pinning sites and other DWs are described via simple phenomenological rules. We first present a detailed description of the model and its algorithmic implementation for simulating the behaviours of arrays of interconnected ring-shaped nanowires, which have previously been proposed as hardware platforms for unconventional computing applications. The model is then validated against a series of experimental measurements of an array's static and dynamic responses to rotating magnetic fields. The robust agreement between the modelled and experimental data demonstrates that agent-based modelling is a powerful tool for exploring mesoscale magnetic devices, enabling time scales and device sizes that are inaccessible to more conventional magnetic simulation techniques.
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- 2024
3. Developing Consistency Among Undergraduate Graders Scoring Open-Ended Statistics Tasks
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Beckman, Matthew D., Burke, Sean, Fiochetta, Jack, Fry, Benjamin, Lloyd, Susan E., Patterson, Luke, and Tang, Elle
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Statistics - Other Statistics - Abstract
Undergraduate graders are frequently important contributors to the teaching team in post-secondary education settings. This study set out to investigate agreement for a team of undergraduate graders as they acquired training and experience for scoring responses to open-ended tasks. Results demonstrate compelling evidence that undergraduate students can develop the ability to establish and sustain substantial agreement with an instructor, especially when equipped with proper training and a high-quality scoring rubric., Comment: Supplemental materials for the preprint available by request from the first author
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- 2024
4. A Deep Learning-Based Method for Metal Artifact-Resistant Syn-MP-RAGE Contrast Synthesis
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Zeng, Ziyi, Wang, Yuhao, Hu, Dianlin, O'Shea, T. Michael, Fry, Rebecca C., Cai, Jing, and Zhang, Lei
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Physics - Medical Physics ,Electrical Engineering and Systems Science - Image and Video Processing - Abstract
In certain brain volumetric studies, synthetic T1-weighted magnetization-prepared rapid gradient-echo (MP-RAGE) contrast, derived from quantitative T1 MRI (T1-qMRI), proves highly valuable due to its clear white/gray matter boundaries for brain segmentation. However, generating synthetic MP-RAGE (syn-MP-RAGE) typically requires pairs of high-quality, artifact-free, multi-modality inputs, which can be challenging in retrospective studies, where missing or corrupted data is common. To overcome this limitation, our research explores the feasibility of employing a deep learning-based approach to synthesize syn-MP-RAGE contrast directly from a single channel turbo spin-echo (TSE) input, renowned for its resistance to metal artifacts. We evaluated this deep learning-based synthetic MP-RAGE (DL-Syn-MPR) on 31 non-artifact and 11 metal-artifact subjects. The segmentation results, measured by the Dice Similarity Coefficient (DSC), consistently achieved high agreement (DSC values above 0.83), indicating a strong correlation with reference segmentations, with lower input requirements. Also, no significant difference in segmentation performance was observed between the artifact and non-artifact groups., Comment: 11 pages, 8 figures, 2 tables
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- 2024
5. An X-Ray Is Worth 15 Features: Sparse Autoencoders for Interpretable Radiology Report Generation
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Abdulaal, Ahmed, Fry, Hugo, Montaña-Brown, Nina, Ijishakin, Ayodeji, Gao, Jack, Hyland, Stephanie, Alexander, Daniel C., and Castro, Daniel C.
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Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Artificial Intelligence - Abstract
Radiological services are experiencing unprecedented demand, leading to increased interest in automating radiology report generation. Existing Vision-Language Models (VLMs) suffer from hallucinations, lack interpretability, and require expensive fine-tuning. We introduce SAE-Rad, which uses sparse autoencoders (SAEs) to decompose latent representations from a pre-trained vision transformer into human-interpretable features. Our hybrid architecture combines state-of-the-art SAE advancements, achieving accurate latent reconstructions while maintaining sparsity. Using an off-the-shelf language model, we distil ground-truth reports into radiological descriptions for each SAE feature, which we then compile into a full report for each image, eliminating the need for fine-tuning large models for this task. To the best of our knowledge, SAE-Rad represents the first instance of using mechanistic interpretability techniques explicitly for a downstream multi-modal reasoning task. On the MIMIC-CXR dataset, SAE-Rad achieves competitive radiology-specific metrics compared to state-of-the-art models while using significantly fewer computational resources for training. Qualitative analysis reveals that SAE-Rad learns meaningful visual concepts and generates reports aligning closely with expert interpretations. Our results suggest that SAEs can enhance multimodal reasoning in healthcare, providing a more interpretable alternative to existing VLMs.
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- 2024
6. The Thermal Structure and Composition of Jupiter's Great Red Spot From JWST/MIRI
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Harkett, Jake, Fletcher, Leigh N., King, Oliver R. T., Roman, Michael T., Melin, Henrik, Hammel, Heidi B., Hueso, Ricardo, Sánchez-Lavega, Agustín, Wong, Michael H., Milam, Stefanie N., Orton, Glenn S., de Kleer, Katherine, Irwin, Patrick G. J., de Pater, Imke, Fouchet, Thierry, Rodríguez-Ovalle, Pablo, Fry, Patrick M., and Showalter, Mark R.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
Jupiter's Great Red Spot (GRS) was mapped by the James Webb Space Telescope (JWST)/Mid-Infrared Instrument (4.9-27.9 micron) in July and August 2022. These observations took place alongside a suite of visual and infrared observations from; Hubble, JWST/NIRCam, Very Large Telescope/VISIR and amateur observers which provided both spatial and temporal context across the jovian disc. The stratospheric temperature structure retrieved using the NEMESIS software revealed a series of hot-spots above the GRS. These could be the consequence of GRS-induced wave activity. In the troposphere, the temperature structure was used to derive the thermal wind structure of the GRS vortex. These winds were only consistent with the independently determined wind field by JWST/NIRCam at 240 mbar if the altitude of the Hubble-derived winds were located around 1,200 mbar, considerably deeper than previously assumed. No enhancement in ammonia was found within the GRS but a link between elevated aerosol and phosphine abundances was observed within this region. North-south asymmetries were observed in the retrieved temperature, ammonia, phosphine and aerosol structure, consistent with the GRS tilting in the north-south direction. Finally, a small storm was captured north-west of the GRS that displayed a considerable excess in retrieved phosphine abundance, suggestive of vigorous convection. Despite this, no ammonia ice was detected in this region. The novelty of JWST required us to develop custom-made software to resolve challenges in calibration of the data. This involved the derivation of the "FLT-5" wavelength calibration solution that has subsequently been integrated into the standard calibration pipeline., Comment: 53 pages, 19 figures, 4 tables
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- 2024
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7. Plurals: A System for Guiding LLMs Via Simulated Social Ensembles
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Ashkinaze, Joshua, Fry, Emily, Edara, Narendra, Gilbert, Eric, and Budak, Ceren
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Computer Science - Computation and Language ,Computer Science - Artificial Intelligence ,Computer Science - Computers and Society ,Computer Science - Human-Computer Interaction ,Computer Science - Multiagent Systems - Abstract
Recent debates raised concerns that language models may favor certain viewpoints. But what if the solution is not to aim for a 'view from nowhere' but rather to leverage different viewpoints? We introduce Plurals, a system and Python library for pluralistic AI deliberation. Plurals consists of Agents (LLMs, optionally with personas) which deliberate within customizable Structures, with Moderators overseeing deliberation. Plurals is a generator of simulated social ensembles. Plurals integrates with government datasets to create nationally representative personas, includes deliberation templates inspired by democratic deliberation theory, and allows users to customize both information-sharing structures and deliberation behavior within Structures. Six case studies demonstrate fidelity to theoretical constructs and efficacy. Three randomized experiments show simulated focus groups produced output resonant with an online sample of the relevant audiences (chosen over zero-shot generation in 75% of trials). Plurals is both a paradigm and a concrete system for pluralistic AI. The Plurals library is available at https://github.com/josh-ashkinaze/plurals and will be continually updated.
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- 2024
8. A patchy CO$_2$ exosphere on Ganymede revealed by the James Webb Space Telescope
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Bockelée-Morvan, Dominique, Poch, Olivier, Leblanc, Françcois, Zakharov, Vladimir, Lellouch, Emmanuel, Quirico, Eric, de Pater, Imke, Fouchet, Thierry, Rodriguez-Ovalle, Pablo, Roth, Lorenz, Merlin, Frédéric, Duling, Stefan, Saur, Joachim, Masson, Adrien, Fry, Patrick, Trumbo, Samantha, Brown, Michael, Cartwright, Richard, Cazaux, Stéphanie, de Kleer, Katherine, Fletcher, Leigh N., Milby, Zachariah, Moingeon, Audrey, Mura, Alessandro, Orton, Glenn S., Schmitt, Bernard, Tosi, Federico, and Wong, Michael H.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
Jupiter's icy moon Ganymede has a tenuous exosphere produced by sputtering and possibly sublimation of water ice. To date, only atomic hydrogen and oxygen have been directly detected in this exosphere. Here, we present observations of Ganymede's CO$_2$ exosphere obtained with the James Webb Space Telescope. CO$_2$ gas is observed over different terrain types, mainly over those exposed to intense Jovian plasma irradiation, as well as over some bright or dark terrains. Despite warm surface temperatures, the CO$_2$ abundance over equatorial subsolar regions is low. CO$_2$ vapor has the highest abundance over the north polar cap of the leading hemisphere, reaching a surface pressure of 1 pbar. From modeling we show that the local enhancement observed near 12 h local time in this region can be explained by the presence of cold traps enabling CO$_2$ adsorption. However, whether the release mechanism in this high-latitude region is sputtering or sublimation remains unclear. The north polar cap of the leading hemisphere also has unique surface-ice properties, probably linked to the presence of the large atmospheric CO2 excess over this region. These CO2 molecules might have been initially released in the atmosphere after the radiolysis of CO$_2$ precursors, or from the sputtering of CO$_2$ embedded in the H$_2$O ice bedrock. Dark terrains (regiones), more widespread on the north versus south polar regions, possibly harbor CO$_2$ precursors. CO$_2$ molecules would then be redistributed via cold trapping on ice-rich terrains of the polar cap and be diurnally released and redeposited on these terrains. Ganymede's CO$_2$ exosphere highlights the complexity of surface-atmosphere interactions on Jupiter's icy Galilean moons., Comment: 21 pages, 21 figures, Accepted as a Letter in Astronomy and Astrophysics
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- 2024
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9. Establishing Social Presence through Online Interactions: A Case Study in a Literacy Clinic
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Mary L. Hoch and Michelle Fry
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During the global pandemic, teachers and students were forced to quickly adjust teaching and learning to fit in the new socially distanced world. Along with the challenge of establishing effective online teaching tools came the need to create social spaces for connecting with students through teacher-student interactions. This study followed the practices of K-12 teachers who were also graduate students seeking an advanced endorsement in literacy as they grappled with problems and solutions of online learning during an intensive K-12 literacy tutoring program. The researchers honed in on the work of one focal teacher as she carved out a new social space for connecting with her students. This work resulted in the identification of specific criteria for three dimensions of social presence: relationship building, engagement, and social interactions.
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- 2024
10. A Systematic Review of CBM Content in Practitioner-Focused Journals: Do We Talk about Instructional Decision-Making?
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Erica C. Fry, Jessica R. Toste, Beth R. Feuer, and Christine A. Espin
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Data-based decision-making (DBDM) using curriculum-based measurement (CBM) data has demonstrated effectiveness in improving academic achievement for students with or at risk for learning disability. Despite substantial evidence supporting DBDM, its use is not common practice for many educators, even those who regularly collect CBM data. One explanation for its lack of widespread use is that educators may not receive adequate training in the DBDM aspects of CBM. Espin et al. examined the extent to which DBDM is represented in CBM professional development (PD) materials and found that the topic was significantly underrepresented (12% to 14% of CBM PD material content) compared with other CBM topics. The purpose of this study was to conduct a conceptual replication of the Espin et al. systematic review through an analysis of CBM content in practitioner journal articles. The present review includes 29 practitioner articles coded to the four CBM categories used in the Espin et al. study: (a) general CBM information, (b) conducting CBM, (c) data-based decision-making, and (d) other. Results revealed a pattern similar to the one found by Espin et al. with approximately 18% of the content of practitioner articles on CBM devoted to the topic of decision-making. These findings strengthen the recommendation from Espin et al. for increased attention to DBDM in CBM training materials.
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- 2024
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11. Heavy tails and negative correlation in a binomial model for sports matches: applications to curling
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Fry, John, Austin, Mark, and Fanzon, Silvio
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Statistics - Applications ,Mathematics - Probability ,62P25, 91-10, 62M99 - Abstract
A binomial model for sports matches is developed making use of the maximum possible score $n$ in a game. In contrast to previous approaches the scores of the two teams are negatively correlated, abstracting from a scenario whereby teams cancel each other out. When $n$ is known, analytical results are possible via a Gaussian approximation. Model calibration is obtained via generalized linear modelling, enabling elementary econometric and strategic analysis to be performed. Inter alia this includes quantifying the Last Stone First End effect, analogous to the home-field advantage found in conventional sports. When $n$ is unknown the model behaviour is richer and leads to heavy-tailed non-Gaussian behaviour. We present an approximate analysis of this case based on the Variance Gamma distribution.
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- 2024
12. A normal version of Brauer's height zero conjecture
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Moretó, Alexander and Fry, A. A. Schaeffer
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Mathematics - Group Theory - Abstract
The celebrated It\^o-Michler theorem asserts that a prime $p$ does not divide the degree of any irreducible character of a finite group $G$ if and only if $G$ has a normal and abelian Sylow $p$-subgroup. The principal block case of the recently-proven Brauer's height zero conjecture isolates the abelian part in the It\^o-Michler theorem. In this paper, we show that the normal part can also be isolated in a similar way. This is a consequence of work on a strong form of the so-called Brauer's height zero conjecture for two primes of Malle and Navarro. Using our techniques, we also provide an alternate proof of this conjecture., Comment: Revised following Gunter Malle's suggestions
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- 2024
13. Schwarz preconditioner with $H_k$-GenEO coarse space for the indefinite Helmholtz problem
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Dolean, Victorita, Fry, Mark, Graham, Ivan G., and Langer, Matthias
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Mathematics - Numerical Analysis ,65N22, 65N55, 65F10 - Abstract
GenEO (`Generalised Eigenvalue problems on the Overlap') is a method from the family of spectral coarse spaces that can efficiently rely on local eigensolves in order to build a robust parallel domain decomposition preconditioner for elliptic PDEs. When used as a preconditioner in a conjugate gradient, this method is extremely efficient in the positive-definite case, yielding an iteration count completely independent of the number of subdomains and heterogeneity. In a previous work this theory was extended to the cased of convection--diffusion--reaction problems, which may be non-self-adjoint and indefinite, and whose discretisations are solved with preconditioned GMRES. The GenEO coarse space was then defined here using a generalised eigenvalue problem based on a self-adjoint and positive definite subproblem. The resulting method, called $\Delta$-GenEO becomes robust with respect to the variation of the coefficient of the diffusion term in the operator and depends only very mildly on variations of the other coefficients. However, the iteration number estimates get worse as the non-self-adjointness and indefiniteness of the operator increases, which is often the case for the high frequency Helmholtz problems. In this work, we will improve on this aspect by introducing a new version, called $H_k$-GenEO, which uses a generalised eigenvalue problem based directly on the indefinite operator which will lead to a robust method with respect to the increase in the wave-number. We provide theoretical estimates showing the dependence of the size of the coarse space on the wave-number., Comment: arXiv admin note: text overlap with arXiv:2403.18378
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- 2024
14. TIDMAD: Time Series Dataset for Discovering Dark Matter with AI Denoising
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Fry, J. T., Li, Aobo, Winslow, Lindley, Fu, Xinyi Hope, Fu, Zhenghao, and Pappas, Kaliroe M. W.
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Computer Science - Machine Learning ,High Energy Physics - Experiment - Abstract
Dark matter makes up approximately 85% of total matter in our universe, yet it has never been directly observed in any laboratory on Earth. The origin of dark matter is one of the most important questions in contemporary physics, and a convincing detection of dark matter would be a Nobel-Prize-level breakthrough in fundamental science. The ABRACADABRA experiment was specifically designed to search for dark matter. Although it has not yet made a discovery, ABRACADABRA has produced several dark matter search results widely endorsed by the physics community. The experiment generates ultra-long time-series data at a rate of 10 million samples per second, where the dark matter signal would manifest itself as a sinusoidal oscillation mode within the ultra-long time series. In this paper, we present the TIDMAD -- a comprehensive data release from the ABRACADABRA experiment including three key components: an ultra-long time series dataset divided into training, validation, and science subsets; a carefully-designed denoising score for direct model benchmarking; and a complete analysis framework which produces a community-standard dark matter search result suitable for publication as a physics paper. This data release enables core AI algorithms to extract the signal and produce real physics results thereby advancing fundamental science. The data downloading and associated analysis scripts are available at https://github.com/jessicafry/TIDMAD
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- 2024
15. Intravenous thrombolysis in acute ischaemic stroke two years into the COVID-19 pandemic: A retrospective study
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Jala, Sheila, Bertmar, Carin, Fry, Margaret, Elliott, Rosalind, Day, Susan, O’Brien, Elizabeth, Priglinger-Coorey, Miriam, and Krause, Martin
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- 2024
16. The Isotope Effect in the Decomposition of Oxalic Acid 1,2
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Fry, Arthur and Calvin, Melvin
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- 2024
17. Development and Validation of a Novel Placental DNA Methylation Biomarker of Maternal Smoking during Pregnancy in the ECHO Program
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Shorey-Kendrick, Lyndsey E, Davis, Brett, Gao, Lina, Park, Byung, Vu, Annette, Morris, Cynthia D, Breton, Carrie V, Fry, Rebecca, Garcia, Erika, Schmidt, Rebecca J, O’Shea, T Michael, Tepper, Robert S, McEvoy, Cindy T, Spindel, Eliot R, and Outcomes, on behalf of program collaborators for Environmental influences on Child Health
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Reproductive Medicine ,Biomedical and Clinical Sciences ,Prevention ,Tobacco Smoke and Health ,Tobacco ,Clinical Research ,Pediatric ,Conditions Affecting the Embryonic and Fetal Periods ,Perinatal Period - Conditions Originating in Perinatal Period ,Reproductive health and childbirth ,Good Health and Well Being ,Humans ,Female ,Pregnancy ,DNA Methylation ,Placenta ,Biomarkers ,Adult ,Double-Blind Method ,Machine Learning ,program collaborators for Environmental influences on Child Health Outcomes ,Environmental Sciences ,Medical and Health Sciences ,Toxicology ,Biomedical and clinical sciences ,Environmental sciences ,Health sciences - Abstract
BackgroundMaternal cigarette smoking during pregnancy (MSDP) is associated with numerous adverse health outcomes in infants and children with potential lifelong consequences. Negative effects of MSDP on placental DNA methylation (DNAm), placental structure, and function are well established.ObjectiveOur aim was to develop biomarkers of MSDP using DNAm measured in placentas (N=96), collected as part of the Vitamin C to Decrease the Effects of Smoking in Pregnancy on Infant Lung Function double-blind, placebo-controlled randomized clinical trial conducted between 2012 and 2016. We also aimed to develop a digital polymerase chain reaction (PCR) assay for the top ranking cytosine-guanine dinucleotide (CpG) so that large numbers of samples can be screened for exposure at low cost.MethodsWe compared the ability of four machine learning methods [logistic least absolute shrinkage and selection operator (LASSO) regression, logistic elastic net regression, random forest, and gradient boosting machine] to classify MSDP based on placental DNAm signatures. We developed separate models using the complete EPIC array dataset and on the subset of probes also found on the 450K array so that models exist for both platforms. For comparison, we developed a model using CpGs previously associated with MSDP in placenta. For each final model, we used model coefficients and normalized beta values to calculate placental smoking index (PSI) scores for each sample. Final models were validated in two external datasets: the Extremely Low Gestational Age Newborn observational study, N=426; and the Rhode Island Children's Health Study, N=237.ResultsLogistic LASSO regression demonstrated the highest performance in cross-validation testing with the lowest number of input CpGs. Accuracy was greatest in external datasets when using models developed for the same platform. PSI scores in smokers only (n=72) were moderately correlated with maternal plasma cotinine levels. One CpG (cg27402634), with the largest coefficient in two models, was measured accurately by digital PCR compared with measurement by EPIC array (R2=0.98).DiscussionTo our knowledge, we have developed the first placental DNAm-based biomarkers of MSDP with broad utility to studies of prenatal disease origins. https://doi.org/10.1289/EHP13838.
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- 2024
18. Network model of skeletal muscle cell signalling predicts differential responses to endurance and resistance exercise training.
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Fowler, Annabelle, Knaus, Katherine, Khuu, Stephanie, Khalilimeybodi, Ali, Schenk, Simon, Ward, Samuel, Fry, Andrew, Rangamani, Padmini, and McCulloch, Andrew
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computational model ,endurance exercise ,exercise ,resistance exercise ,signalling network ,skeletal muscle ,Humans ,Signal Transduction ,Muscle ,Skeletal ,Resistance Training ,Physical Endurance ,Animals ,Adaptation ,Physiological ,Exercise ,Models ,Biological - Abstract
Exercise-induced muscle adaptations vary based on exercise modality and intensity. We constructed a signalling network model from 87 published studies of human or rodent skeletal muscle cell responses to endurance or resistance exercise in vivo or simulated exercise in vitro. The network comprises 259 signalling interactions between 120 nodes, representing eight membrane receptors and eight canonical signalling pathways regulating 14 transcriptional regulators, 28 target genes and 12 exercise-induced phenotypes. Using this network, we formulated a logic-based ordinary differential equation model predicting time-dependent molecular and phenotypic alterations following acute endurance and resistance exercises. Compared with nine independent studies, the model accurately predicted 18/21 (85%) acute responses to resistance exercise and 12/16 (75%) acute responses to endurance exercise. Detailed sensitivity analysis of differential phenotypic responses to resistance and endurance training showed that, in the model, exercise regulates cell growth and protein synthesis primarily by signalling via mechanistic target of rapamycin, which is activated by Akt and inhibited in endurance exercise by AMP-activated protein kinase. Endurance exercise preferentially activates inflammation via reactive oxygen species and nuclear factor κB signalling. Furthermore, the expected preferential activation of mitochondrial biogenesis by endurance exercise was counterbalanced in the model by protein kinase C in response to resistance training. This model provides a new tool for investigating cross-talk between skeletal muscle signalling pathways activated by endurance and resistance exercise, and the mechanisms of interactions such as the interference effects of endurance training on resistance exercise outcomes.
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- 2024
19. Characters and Sylow $3$-subgroup abelianization
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Giannelli, Eugenio, Rizo, Noelia, Fry, A. A. Schaeffer, and Vallejo, Carolina
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Mathematics - Group Theory ,Mathematics - Representation Theory - Abstract
We characterize when a finite group G possesses a Sylow 3-subgroup P with abelianization of order 9 in terms of the number of height zero characters lying in the principal 3-block of G, settling a conjecture put forward by Navarro, Sambale, and Tiep in 2018. Along the way, we show that a recent result by Laradji on the number of character of height zero in a block that lie above a given character of some normal subgroup holds, without any hypothesis on the group for blocks of maximal defect., Comment: slight title change and other minor changes, following helpful comments thanks to Gunter Malle and Bejamin Sambale
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- 2024
20. The sounds of science a symphony for many instruments and voices part II
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Hooft, Gerard t, Phillips, William D, Zeilinger, Anton, Allen, Roland, Baggott, Jim, Bouchet, Francois R, Cantanhede, Solange M G, Castanedo, Lazaro A M, Cetto, Ana Maria, Coley, Alan A, Dalton, Bryan J, Fahimi, Peyman, Franks, Sharon, Frano, Alex, Fry, Edward S, Goldfarb, Steven, Langanke, Karlheinz, Matta, Cherif F, Nanopoulos, Dimitri, Orzel, Chad, Patrick, Sam, Sanghai, Viraj A A, Schuller, Ivan K, Shpyrko, Oleg, and Lidstrom, Suzy
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Physics - Physics and Society - Abstract
Despite its amazing quantitative successes and contributions to revolutionary technologies, physics currently faces many unsolved mysteries ranging from the meaning of quantum mechanics to the nature of the dark energy that will determine the future of the Universe. It is clearly prohibitive for the general reader, and even the best informed physicists, to follow the vast number of technical papers published in the thousands of specialized journals. For this reason, we have asked the leading experts across many of the most important areas of physics to summarise their global assessment of some of the most important issues. In lieu of an extremely long abstract summarising the contents, we invite the reader to look at the section headings and their authors, and then to indulge in a feast of stimulating topics spanning the current frontiers of fundamental physics from The Future of Physics by William D Phillips and What characterises topological effects in physics? by Gerard t Hooft through the contributions of the widest imaginable range of world leaders in their respective areas. This paper is presented as a preface to exciting developments by senior and young scientists in the years that lie ahead, and a complement to the less authoritative popular accounts by journalists., Comment: 54 pages, 13 figures
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- 2024
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21. Improvements to the theoretical estimates of the Schwarz preconditioner with $\Delta$-GenEO coarse space for the indefinite Helmholtz problem
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Dolean, Victorita, Fry, Mark, and Langer, Matthias
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Mathematics - Numerical Analysis ,65N22, 65N55, 65F10 - Abstract
The purpose of this work is to improve the estimates for the $\Delta$-GenEO method from the paper "Overlapping Schwarz methods with GenEO coarse spaces for indefinite and nonself-adjoint problems" by N. Bootland, V. Dolean, I. G Graham, C. Ma, R. Scheichl (https://doi.org/10.1093/imanum/drac036) when applied to the indefinite Helmholtz equation. We derive k-dependent estimates of quantities of interest ensuring the robustness of the method.
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- 2024
22. Gemini 1.5: Unlocking multimodal understanding across millions of tokens of context
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Gemini Team, Georgiev, Petko, Lei, Ving Ian, Burnell, Ryan, Bai, Libin, Gulati, Anmol, Tanzer, Garrett, Vincent, Damien, Pan, Zhufeng, Wang, Shibo, Mariooryad, Soroosh, Ding, Yifan, Geng, Xinyang, Alcober, Fred, Frostig, Roy, Omernick, Mark, Walker, Lexi, Paduraru, Cosmin, Sorokin, Christina, Tacchetti, Andrea, Gaffney, Colin, Daruki, Samira, Sercinoglu, Olcan, Gleicher, Zach, Love, Juliette, Voigtlaender, Paul, Jain, Rohan, Surita, Gabriela, Mohamed, Kareem, Blevins, Rory, Ahn, Junwhan, Zhu, Tao, Kawintiranon, Kornraphop, Firat, Orhan, Gu, Yiming, Zhang, Yujing, Rahtz, Matthew, Faruqui, Manaal, Clay, Natalie, Gilmer, Justin, Co-Reyes, JD, Penchev, Ivo, Zhu, Rui, Morioka, Nobuyuki, Hui, Kevin, Haridasan, Krishna, Campos, Victor, Mahdieh, Mahdis, Guo, Mandy, Hassan, Samer, Kilgour, Kevin, Vezer, Arpi, Cheng, Heng-Tze, de Liedekerke, Raoul, Goyal, Siddharth, Barham, Paul, Strouse, DJ, Noury, Seb, Adler, Jonas, Sundararajan, Mukund, Vikram, Sharad, Lepikhin, Dmitry, Paganini, Michela, Garcia, Xavier, Yang, Fan, Valter, Dasha, Trebacz, Maja, Vodrahalli, Kiran, Asawaroengchai, Chulayuth, Ring, Roman, Kalb, Norbert, Soares, Livio Baldini, Brahma, Siddhartha, Steiner, David, Yu, Tianhe, Mentzer, Fabian, He, Antoine, Gonzalez, Lucas, Xu, Bibo, Kaufman, Raphael Lopez, Shafey, Laurent El, Oh, Junhyuk, Hennigan, Tom, Driessche, George van den, Odoom, Seth, Lucic, Mario, Roelofs, Becca, Lall, Sid, Marathe, Amit, Chan, Betty, Ontanon, Santiago, He, Luheng, Teplyashin, Denis, Lai, Jonathan, Crone, Phil, Damoc, Bogdan, Ho, Lewis, Riedel, Sebastian, Lenc, Karel, Yeh, Chih-Kuan, Chowdhery, Aakanksha, Xu, Yang, Kazemi, Mehran, Amid, Ehsan, Petrushkina, Anastasia, Swersky, Kevin, Khodaei, Ali, Chen, Gowoon, Larkin, Chris, Pinto, Mario, Yan, Geng, Badia, Adria Puigdomenech, Patil, Piyush, Hansen, Steven, Orr, Dave, Arnold, Sebastien M. R., Grimstad, Jordan, Dai, Andrew, Douglas, Sholto, Sinha, Rishika, Yadav, Vikas, Chen, Xi, Gribovskaya, Elena, Austin, Jacob, Zhao, Jeffrey, Patel, Kaushal, Komarek, Paul, Austin, Sophia, Borgeaud, Sebastian, Friso, Linda, Goyal, Abhimanyu, Caine, Ben, Cao, Kris, Chung, Da-Woon, Lamm, Matthew, Barth-Maron, Gabe, Kagohara, Thais, Olszewska, Kate, Chen, Mia, Shivakumar, Kaushik, Agarwal, Rishabh, Godhia, Harshal, Rajwar, Ravi, Snaider, Javier, Dotiwalla, Xerxes, Liu, Yuan, Barua, Aditya, Ungureanu, Victor, Zhang, Yuan, Batsaikhan, Bat-Orgil, Wirth, Mateo, Qin, James, Danihelka, Ivo, Doshi, Tulsee, Chadwick, Martin, Chen, Jilin, Jain, Sanil, Le, Quoc, Kar, Arjun, Gurumurthy, Madhu, Li, Cheng, Sang, Ruoxin, Liu, Fangyu, Lamprou, Lampros, Munoz, Rich, Lintz, Nathan, Mehta, Harsh, Howard, Heidi, Reynolds, Malcolm, Aroyo, Lora, Wang, Quan, Blanco, Lorenzo, Cassirer, Albin, Griffith, Jordan, Das, Dipanjan, Lee, Stephan, Sygnowski, Jakub, Fisher, Zach, Besley, James, Powell, Richard, Ahmed, Zafarali, Paulus, Dominik, Reitter, David, Borsos, Zalan, Joshi, Rishabh, Pope, Aedan, Hand, Steven, Selo, Vittorio, Jain, Vihan, Sethi, Nikhil, Goel, Megha, Makino, Takaki, May, Rhys, Yang, Zhen, Schalkwyk, Johan, Butterfield, Christina, Hauth, Anja, Goldin, Alex, Hawkins, Will, Senter, Evan, Brin, Sergey, Woodman, Oliver, Ritter, Marvin, Noland, Eric, Giang, Minh, Bolina, Vijay, Lee, Lisa, Blyth, Tim, Mackinnon, Ian, Reid, Machel, Sarvana, Obaid, Silver, David, Chen, Alexander, Wang, Lily, Maggiore, Loren, Chang, Oscar, Attaluri, Nithya, Thornton, Gregory, Chiu, Chung-Cheng, Bunyan, Oskar, Levine, Nir, Chung, Timothy, Eltyshev, Evgenii, Si, Xiance, Lillicrap, Timothy, Brady, Demetra, Aggarwal, Vaibhav, Wu, Boxi, Xu, Yuanzhong, McIlroy, Ross, Badola, Kartikeya, Sandhu, Paramjit, Moreira, Erica, Stokowiec, Wojciech, Hemsley, Ross, Li, Dong, Tudor, Alex, Shyam, Pranav, Rahimtoroghi, Elahe, Haykal, Salem, Sprechmann, Pablo, Zhou, Xiang, Mincu, Diana, Li, Yujia, Addanki, Ravi, Krishna, Kalpesh, Wu, Xiao, Frechette, Alexandre, Eyal, Matan, Dafoe, Allan, Lacey, Dave, Whang, Jay, Avrahami, Thi, Zhang, Ye, Taropa, Emanuel, Lin, Hanzhao, Toyama, Daniel, Rutherford, Eliza, Sano, Motoki, Choe, HyunJeong, Tomala, Alex, Safranek-Shrader, Chalence, Kassner, Nora, Pajarskas, Mantas, Harvey, Matt, Sechrist, Sean, Fortunato, Meire, Lyu, Christina, Elsayed, Gamaleldin, Kuang, Chenkai, Lottes, James, Chu, Eric, Jia, Chao, Chen, Chih-Wei, Humphreys, Peter, Baumli, Kate, Tao, Connie, Samuel, Rajkumar, Santos, Cicero Nogueira dos, Andreassen, Anders, Rakićević, Nemanja, Grewe, Dominik, Kumar, Aviral, Winkler, Stephanie, Caton, Jonathan, Brock, Andrew, Dalmia, Sid, Sheahan, Hannah, Barr, Iain, Miao, Yingjie, Natsev, Paul, Devlin, Jacob, Behbahani, Feryal, Prost, Flavien, Sun, Yanhua, Myaskovsky, Artiom, Pillai, Thanumalayan Sankaranarayana, Hurt, Dan, Lazaridou, Angeliki, Xiong, Xi, Zheng, Ce, Pardo, Fabio, Li, Xiaowei, Horgan, Dan, Stanton, Joe, Ambar, Moran, Xia, Fei, Lince, 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Ada, Gottweis, Juraj, Xing, Jinwei, Gu, Chenjie, Miao, Jin, Frank, Christian, Cankara, Zeynep, Ganapathy, Sanjay, Dasgupta, Ishita, Hughes-Fitt, Steph, Chen, Heng, Reid, David, Rong, Keran, Fan, Hongmin, van Amersfoort, Joost, Zhuang, Vincent, Cohen, Aaron, Gu, Shixiang Shane, Mohananey, Anhad, Ilic, Anastasija, Tobin, Taylor, Wieting, John, Bortsova, Anna, Thacker, Phoebe, Wang, Emma, Caveness, Emily, Chiu, Justin, Sezener, Eren, Kaskasoli, Alex, Baker, Steven, Millican, Katie, Elhawaty, Mohamed, Aisopos, Kostas, Lebsack, Carl, Byrd, Nathan, Dai, Hanjun, Jia, Wenhao, Wiethoff, Matthew, Davoodi, Elnaz, Weston, Albert, Yagati, Lakshman, Ahuja, Arun, Gao, Isabel, Pundak, Golan, Zhang, Susan, Azzam, Michael, Sim, Khe Chai, Caelles, Sergi, Keeling, James, Sharma, Abhanshu, Swing, Andy, Li, YaGuang, Liu, Chenxi, Bostock, Carrie Grimes, Bansal, Yamini, Nado, Zachary, Anand, Ankesh, Lipschultz, Josh, Karmarkar, Abhijit, Proleev, Lev, Ittycheriah, Abe, Yeganeh, Soheil Hassas, Polovets, George, Faust, Aleksandra, Sun, Jiao, Rrustemi, Alban, Li, Pen, Shivanna, Rakesh, Liu, Jeremiah, Welty, Chris, Lebron, Federico, Baddepudi, Anirudh, Krause, Sebastian, Parisotto, Emilio, Soricut, Radu, Xu, Zheng, Bloxwich, Dawn, Johnson, Melvin, Neyshabur, Behnam, Mao-Jones, Justin, Wang, Renshen, Ramasesh, Vinay, Abbas, Zaheer, Guez, Arthur, Segal, Constant, Nguyen, Duc Dung, Svensson, James, Hou, Le, York, Sarah, Milan, Kieran, Bridgers, Sophie, Gworek, Wiktor, Tagliasacchi, Marco, Lee-Thorp, James, Chang, Michael, Guseynov, Alexey, Hartman, Ale Jakse, Kwong, Michael, Zhao, Ruizhe, Kashem, Sheleem, Cole, Elizabeth, Miech, Antoine, Tanburn, Richard, Phuong, Mary, Pavetic, Filip, Cevey, Sebastien, Comanescu, Ramona, Ives, Richard, Yang, Sherry, Du, Cosmo, Li, Bo, Zhang, Zizhao, Iinuma, Mariko, Hu, Clara Huiyi, Roy, Aurko, Bijwadia, Shaan, Zhu, Zhenkai, Martins, Danilo, Saputro, Rachel, Gergely, Anita, Zheng, Steven, Jia, Dawei, Antonoglou, Ioannis, Sadovsky, Adam, Gu, Shane, Bi, Yingying, Andreev, Alek, Samangooei, Sina, Khan, Mina, Kocisky, Tomas, Filos, Angelos, Kumar, Chintu, Bishop, Colton, Yu, Adams, Hodkinson, Sarah, Mittal, Sid, Shah, Premal, Moufarek, Alexandre, Cheng, Yong, Bloniarz, Adam, Lee, Jaehoon, Pejman, Pedram, Michel, Paul, Spencer, Stephen, Feinberg, Vladimir, Xiong, Xuehan, Savinov, Nikolay, Smith, Charlotte, Shakeri, Siamak, Tran, Dustin, Chesus, Mary, Bohnet, Bernd, Tucker, George, von Glehn, Tamara, Muir, Carrie, Mao, Yiran, Kazawa, Hideto, Slone, Ambrose, Soparkar, Kedar, Shrivastava, Disha, Cobon-Kerr, James, Sharman, Michael, Pavagadhi, Jay, Araya, Carlos, Misiunas, Karolis, Ghelani, Nimesh, Laskin, Michael, Barker, David, Li, Qiujia, Briukhov, Anton, Houlsby, Neil, Glaese, Mia, Lakshminarayanan, Balaji, Schucher, Nathan, Tang, Yunhao, Collins, Eli, Lim, Hyeontaek, Feng, Fangxiaoyu, Recasens, Adria, Lai, Guangda, Magni, Alberto, De Cao, Nicola, Siddhant, Aditya, Ashwood, Zoe, Orbay, Jordi, Dehghani, Mostafa, Brennan, Jenny, He, Yifan, Xu, Kelvin, Gao, Yang, Saroufim, Carl, Molloy, James, Wu, Xinyi, Arnold, Seb, Chang, Solomon, Schrittwieser, Julian, Buchatskaya, Elena, Radpour, Soroush, Polacek, Martin, Giordano, Skye, Bapna, Ankur, Tokumine, Simon, Hellendoorn, Vincent, Sottiaux, Thibault, Cogan, Sarah, Severyn, Aliaksei, Saleh, Mohammad, Thakoor, Shantanu, Shefey, Laurent, Qiao, Siyuan, Gaba, Meenu, Chang, Shuo-yiin, Swanson, Craig, Zhang, Biao, Lee, Benjamin, Rubenstein, Paul Kishan, Song, Gan, Kwiatkowski, Tom, Koop, Anna, Kannan, Ajay, Kao, David, Schuh, Parker, Stjerngren, Axel, Ghiasi, Golnaz, Gibson, Gena, Vilnis, Luke, Yuan, Ye, Ferreira, Felipe Tiengo, Kamath, Aishwarya, Klimenko, Ted, Franko, Ken, Xiao, Kefan, Bhattacharya, Indro, Patel, Miteyan, Wang, Rui, Morris, Alex, Strudel, Robin, Sharma, Vivek, Choy, Peter, Hashemi, Sayed Hadi, Landon, Jessica, Finkelstein, Mara, Jhakra, Priya, Frye, Justin, Barnes, Megan, Mauger, Matthew, Daun, Dennis, Baatarsukh, Khuslen, Tung, Matthew, Farhan, Wael, Michalewski, Henryk, Viola, Fabio, Quitry, Felix de Chaumont, Lan, Charline Le, Hudson, Tom, Wang, Qingze, Fischer, Felix, Zheng, Ivy, White, Elspeth, Dragan, Anca, Alayrac, Jean-baptiste, Ni, Eric, Pritzel, Alexander, Iwanicki, Adam, Isard, Michael, Bulanova, Anna, Zilka, Lukas, Dyer, Ethan, Sachan, Devendra, Srinivasan, Srivatsan, Muckenhirn, Hannah, Cai, Honglong, Mandhane, Amol, Tariq, Mukarram, Rae, Jack W., Wang, Gary, Ayoub, Kareem, FitzGerald, Nicholas, Zhao, Yao, Han, Woohyun, Alberti, Chris, Garrette, Dan, Krishnakumar, Kashyap, Gimenez, Mai, Levskaya, Anselm, Sohn, Daniel, Matak, Josip, Iturrate, Inaki, Chang, Michael B., Xiang, Jackie, Cao, Yuan, Ranka, Nishant, Brown, Geoff, Hutter, Adrian, Mirrokni, Vahab, Chen, Nanxin, Yao, Kaisheng, Egyed, Zoltan, Galilee, Francois, Liechty, Tyler, Kallakuri, Praveen, Palmer, Evan, Ghemawat, Sanjay, Liu, Jasmine, Tao, David, Thornton, Chloe, Green, Tim, Jasarevic, Mimi, Lin, Sharon, Cotruta, Victor, Tan, Yi-Xuan, Fiedel, Noah, Yu, Hongkun, Chi, Ed, Neitz, Alexander, Heitkaemper, Jens, Sinha, Anu, Zhou, Denny, Sun, Yi, Kaed, Charbel, Hulse, Brice, Mishra, Swaroop, Georgaki, Maria, Kudugunta, Sneha, Farabet, Clement, Shafran, Izhak, Vlasic, Daniel, Tsitsulin, Anton, Ananthanarayanan, Rajagopal, Carin, Alen, Su, Guolong, Sun, Pei, V, Shashank, Carvajal, Gabriel, Broder, Josef, Comsa, Iulia, Repina, Alena, Wong, William, Chen, Warren Weilun, Hawkins, Peter, Filonov, Egor, Loher, Lucia, Hirnschall, Christoph, Wang, Weiyi, Ye, Jingchen, Burns, Andrea, Cate, Hardie, Wright, Diana Gage, Piccinini, Federico, Zhang, Lei, Lin, Chu-Cheng, Gog, Ionel, Kulizhskaya, Yana, Sreevatsa, Ashwin, Song, Shuang, Cobo, Luis C., Iyer, Anand, Tekur, Chetan, Garrido, Guillermo, Xiao, Zhuyun, Kemp, Rupert, Zheng, Huaixiu Steven, Li, Hui, Agarwal, Ananth, Ngani, Christel, Goshvadi, Kati, Santamaria-Fernandez, Rebeca, Fica, Wojciech, Chen, Xinyun, Gorgolewski, Chris, Sun, Sean, Garg, Roopal, Ye, Xinyu, Eslami, S. M. Ali, Hua, Nan, Simon, Jon, Joshi, Pratik, Kim, Yelin, Tenney, Ian, Potluri, Sahitya, Thiet, Lam Nguyen, Yuan, Quan, Luisier, Florian, Chronopoulou, Alexandra, Scellato, Salvatore, Srinivasan, Praveen, Chen, Minmin, Koverkathu, Vinod, Dalibard, Valentin, Xu, Yaming, Saeta, Brennan, Anderson, Keith, Sellam, Thibault, Fernando, Nick, Huot, Fantine, Jung, Junehyuk, Varadarajan, Mani, Quinn, Michael, Raul, Amit, Le, Maigo, Habalov, Ruslan, Clark, Jon, Jalan, Komal, Bullard, Kalesha, Singhal, Achintya, Luong, Thang, Wang, Boyu, Rajayogam, Sujeevan, Eisenschlos, Julian, Jia, Johnson, Finchelstein, Daniel, Yakubovich, Alex, Balle, Daniel, Fink, Michael, Agarwal, Sameer, Li, Jing, Dvijotham, Dj, Pal, Shalini, Kang, Kai, Konzelmann, Jaclyn, Beattie, Jennifer, Dousse, Olivier, Wu, Diane, Crocker, Remi, Elkind, Chen, Jonnalagadda, Siddhartha Reddy, Lee, Jong, Holtmann-Rice, Dan, Kallarackal, Krystal, Liu, Rosanne, Vnukov, Denis, Vats, Neera, Invernizzi, Luca, Jafari, Mohsen, Zhou, Huanjie, Taylor, Lilly, Prendki, Jennifer, Wu, Marcus, Eccles, Tom, Liu, Tianqi, Kopparapu, Kavya, Beaufays, Francoise, Angermueller, Christof, Marzoca, Andreea, Sarcar, Shourya, Dib, Hilal, Stanway, Jeff, Perbet, Frank, Trdin, Nejc, Sterneck, Rachel, Khorlin, Andrey, Li, Dinghua, Wu, Xihui, Goenka, Sonam, Madras, David, Goldshtein, Sasha, Gierke, Willi, Zhou, Tong, Liu, Yaxin, Liang, Yannie, White, Anais, Li, Yunjie, Singh, Shreya, Bahargam, Sanaz, Epstein, Mark, Basu, Sujoy, Lao, Li, Ozturel, Adnan, Crous, Carl, Zhai, Alex, Lu, Han, Tung, Zora, Gaur, Neeraj, Walton, Alanna, Dixon, Lucas, Zhang, Ming, Globerson, Amir, Uy, Grant, Bolt, Andrew, Wiles, Olivia, Nasr, Milad, Shumailov, Ilia, Selvi, Marco, Piccinno, Francesco, Aguilar, Ricardo, McCarthy, Sara, Khalman, Misha, Shukla, Mrinal, Galic, Vlado, Carpenter, John, Villela, Kevin, Zhang, Haibin, Richardson, Harry, Martens, James, Bosnjak, Matko, Belle, Shreyas Rammohan, Seibert, Jeff, Alnahlawi, Mahmoud, McWilliams, Brian, Singh, Sankalp, Louis, Annie, Ding, Wen, Popovici, Dan, Simicich, Lenin, Knight, Laura, Mehta, Pulkit, Gupta, Nishesh, Shi, Chongyang, Fatehi, Saaber, Mitrovic, Jovana, Grills, Alex, Pagadora, Joseph, Petrova, Dessie, Eisenbud, Danielle, Zhang, Zhishuai, Yates, Damion, Mittal, Bhavishya, Tripuraneni, Nilesh, Assael, Yannis, Brovelli, Thomas, Jain, Prateek, Velimirovic, Mihajlo, Akbulut, Canfer, Mu, Jiaqi, Macherey, Wolfgang, Kumar, Ravin, Xu, Jun, Qureshi, Haroon, Comanici, Gheorghe, Wiesner, Jeremy, Gong, Zhitao, Ruddock, Anton, Bauer, Matthias, Felt, Nick, GP, Anirudh, Arnab, Anurag, Zelle, Dustin, Rothfuss, Jonas, Rosgen, Bill, Shenoy, Ashish, Seybold, Bryan, Li, Xinjian, Mudigonda, Jayaram, Erdogan, Goker, Xia, Jiawei, Simsa, Jiri, Michi, Andrea, Yao, Yi, Yew, Christopher, Kan, Steven, Caswell, Isaac, Radebaugh, Carey, Elisseeff, Andre, Valenzuela, Pedro, McKinney, Kay, Paterson, Kim, Cui, Albert, Latorre-Chimoto, Eri, Kim, Solomon, Zeng, William, Durden, Ken, Ponnapalli, Priya, Sosea, Tiberiu, Choquette-Choo, Christopher A., Manyika, James, Robenek, Brona, Vashisht, Harsha, Pereira, Sebastien, Lam, Hoi, Velic, Marko, Owusu-Afriyie, Denese, Lee, Katherine, Bolukbasi, Tolga, Parrish, Alicia, Lu, Shawn, Park, Jane, Venkatraman, Balaji, Talbert, Alice, Rosique, Lambert, Cheng, Yuchung, Sozanschi, Andrei, Paszke, Adam, Kumar, Praveen, Austin, Jessica, Li, Lu, Salama, Khalid, Kim, Wooyeol, Dukkipati, Nandita, Baryshnikov, Anthony, Kaplanis, Christos, Sheng, XiangHai, Chervonyi, Yuri, Unlu, Caglar, Casas, Diego de Las, Askham, Harry, Tunyasuvunakool, Kathryn, Gimeno, Felix, Poder, Siim, Kwak, Chester, Miecnikowski, Matt, Dimitriev, Alek, Parisi, Aaron, Liu, Dangyi, Tsai, Tomy, Shevlane, Toby, Kouridi, Christina, Garmon, Drew, Goedeckemeyer, Adrian, Brown, Adam R., Vijayakumar, Anitha, Elqursh, Ali, Jazayeri, Sadegh, Huang, Jin, Carthy, Sara Mc, Hoover, Jay, Kim, Lucy, Kumar, Sandeep, Chen, Wei, Biles, Courtney, Bingham, Garrett, Rosen, Evan, Wang, Lisa, Tan, Qijun, Engel, David, Pongetti, Francesco, de Cesare, Dario, Hwang, Dongseong, Yu, Lily, Pullman, Jennifer, Narayanan, Srini, Levin, Kyle, Gopal, Siddharth, Li, Megan, Aharoni, Asaf, Trinh, Trieu, Lo, Jessica, Casagrande, Norman, Vij, Roopali, Matthey, Loic, Ramadhana, Bramandia, Matthews, Austin, Carey, CJ, Johnson, Matthew, Goranova, Kremena, Shah, Rohin, Ashraf, Shereen, Dasgupta, Kingshuk, Larsen, Rasmus, Wang, Yicheng, Vuyyuru, Manish Reddy, Jiang, Chong, Ijazi, Joana, Osawa, Kazuki, Smith, Celine, Boppana, Ramya Sree, Bilal, Taylan, Koizumi, Yuma, Xu, Ying, Altun, Yasemin, Shabat, Nir, Bariach, Ben, Korchemniy, Alex, Choo, Kiam, Ronneberger, Olaf, Iwuanyanwu, Chimezie, Zhao, Shubin, Soergel, David, Hsieh, Cho-Jui, Cai, Irene, Iqbal, Shariq, Sundermeyer, Martin, Chen, Zhe, Bursztein, Elie, Malaviya, Chaitanya, Biadsy, Fadi, Shroff, Prakash, Dhillon, Inderjit, Latkar, Tejasi, Dyer, Chris, Forbes, Hannah, Nicosia, Massimo, Nikolaev, Vitaly, Greene, Somer, Georgiev, Marin, Wang, Pidong, Martin, Nina, Sedghi, Hanie, Zhang, John, Banzal, Praseem, Fritz, Doug, Rao, Vikram, Wang, Xuezhi, Zhang, Jiageng, Patraucean, Viorica, Du, Dayou, Mordatch, Igor, Jurin, Ivan, Liu, Lewis, Dubey, Ayush, Mohan, Abhi, Nowakowski, Janek, Ion, Vlad-Doru, Wei, Nan, Tojo, Reiko, Raad, Maria Abi, Hudson, Drew A., Keshava, Vaishakh, Agrawal, Shubham, Ramirez, Kevin, Wu, Zhichun, Nguyen, Hoang, Liu, Ji, Sewak, Madhavi, Petrini, Bryce, Choi, DongHyun, Philips, Ivan, Wang, Ziyue, Bica, Ioana, Garg, Ankush, Wilkiewicz, Jarek, Agrawal, Priyanka, Guo, Danhao, Xue, Emily, Shaik, Naseer, Leach, Andrew, Khan, Sadh MNM, Wiesinger, Julia, Jerome, Sammy, Chakladar, Abhishek, Wang, Alek Wenjiao, Ornduff, Tina, Abu, Folake, Ghaffarkhah, Alireza, Wainwright, Marcus, Cortes, Mario, Liu, Frederick, Maynez, Joshua, Terzis, Andreas, Samangouei, Pouya, Mansour, Riham, Kępa, Tomasz, Aubet, François-Xavier, Algymr, Anton, Banica, Dan, Weisz, Agoston, Orban, Andras, Senges, Alexandre, Andrejczuk, Ewa, Geller, Mark, Santo, Niccolo Dal, Anklin, Valentin, Merey, Majd Al, Baeuml, Martin, Strohman, Trevor, Bai, Junwen, Petrov, Slav, Wu, Yonghui, Hassabis, Demis, Kavukcuoglu, Koray, Dean, Jeffrey, and Vinyals, Oriol
- Subjects
Computer Science - Computation and Language ,Computer Science - Artificial Intelligence - Abstract
In this report, we introduce the Gemini 1.5 family of models, representing the next generation of highly compute-efficient multimodal models capable of recalling and reasoning over fine-grained information from millions of tokens of context, including multiple long documents and hours of video and audio. The family includes two new models: (1) an updated Gemini 1.5 Pro, which exceeds the February version on the great majority of capabilities and benchmarks; (2) Gemini 1.5 Flash, a more lightweight variant designed for efficiency with minimal regression in quality. Gemini 1.5 models achieve near-perfect recall on long-context retrieval tasks across modalities, improve the state-of-the-art in long-document QA, long-video QA and long-context ASR, and match or surpass Gemini 1.0 Ultra's state-of-the-art performance across a broad set of benchmarks. Studying the limits of Gemini 1.5's long-context ability, we find continued improvement in next-token prediction and near-perfect retrieval (>99%) up to at least 10M tokens, a generational leap over existing models such as Claude 3.0 (200k) and GPT-4 Turbo (128k). Finally, we highlight real-world use cases, such as Gemini 1.5 collaborating with professionals on completing their tasks achieving 26 to 75% time savings across 10 different job categories, as well as surprising new capabilities of large language models at the frontier; when given a grammar manual for Kalamang, a language with fewer than 200 speakers worldwide, the model learns to translate English to Kalamang at a similar level to a person who learned from the same content.
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- 2024
23. Comparisons of 30-day outcomes after ventral hernia repair by body mass index and surgical approach: a retrospective cohort study
- Author
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Hallway, Alexander K., Sinamo, Joshua K., Fry, Brian T., Kappelman, Abigail L., Huynh, Desmond, Schoel, Leah J., O’Neill, Sean M., Rubyan, Michael, Shao, Jenny M., Telem, Dana A., and Ehlers, Anne P.
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- 2024
- Full Text
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24. Two decades of advances in clinical oncology — lessons learned and future directions
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Banerjee, Susana, Booth, Christopher M., Bruera, Eduardo, Büchler, Markus W., Drilon, Alexander, Fry, Terry J., Ghobrial, Irene M., Gianni, Luca, Jain, Rakesh K., Kroemer, Guido, Llovet, Josep M., Long, Georgina V., Pantel, Klaus, Pritchard-Jones, Kathy, Scher, Howard I., Tabernero, Josep, Weichselbaum, Ralph R., Weller, Michael, and Wu, Yi-Long
- Published
- 2024
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25. An Open-Label Extension Study Assessing the Long-Term Safety and Efficacy of Viloxazine Extended-Release Capsules in Adults with Attention-Deficit/Hyperactivity Disorder
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Childress, Ann, Cutler, Andrew J., Adler, Lenard A., Fry, Nicholas, Asubonteng, Kobby, Maldonado-Cruz, Zulane, Formella, Andrea, and Rubin, Jonathan
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- 2024
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26. Heterogeneity in the surgical approach to recurrent abdominal wall hernias: an opportunity for quality improvement
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Schoel, Leah J., Sinamo, Joshua, Williams, Jonathan, Hallway, Alexander, Fry, Brian T., Rubyan, Michael, Shao, Jenny M., O’Neill, Sean M., Telem, Dana A., and Ehlers, Anne P.
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- 2024
- Full Text
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27. The 24-hour molecular landscape after exercise in humans reveals MYC is sufficient for muscle growth
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Edman, Sebastian, Jones III, Ronald G, Jannig, Paulo R, Fernandez-Gonzalo, Rodrigo, Norrbom, Jessica, Thomas, Nicholas T, Khadgi, Sabin, Koopmans, Pieter J, Morena, Francielly, Chambers, Toby L, Peterson, Calvin S, Scott, Logan N, Greene, Nicholas P, Figueiredo, Vandre C, Fry, Christopher S, Zhengye, Liu, Lanner, Johanna T, Wen, Yuan, Alkner, Björn, Murach, Kevin A, and von Walden, Ferdinand
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- 2024
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28. Understanding patient experiences to improve care for females groin hernia
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Sukhon, Deena, Bradley, Sarah E., Hallway, Alex, Fry, Brian, Hosea, Forrest, Schoel, Leah, Rubyan, Michael, Shao, Jenny, O’Neill, Sean, Telem, Dana, and Ehlers, Anne P.
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- 2024
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29. Long-term patient reported outcomes after robotic, laparoscopic, and open ventral hernia repair
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Fry, Brian T., Kappelman, Abigail L., Sinamo, Joshua K., Huynh, Desmond, Schoel, Leah J., Hallway, Alexander K., Ehlers, Anne P., O’Neill, Sean M., Rubyan, Michael A., Shao, Jenny M., and Telem, Dana A.
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- 2024
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30. Space radiation measurements during the Artemis I lunar mission
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George, Stuart P., Gaza, Ramona, Matthiä, Daniel, Laramore, Diego, Lehti, Jussi, Campbell-Ricketts, Thomas, Kroupa, Martin, Stoffle, Nicholas, Marsalek, Karel, Przybyla, Bartos, Abdelmelek, Mena, Aeckerlein, Joachim, Bahadori, Amir A., Barzilla, Janet, Dieckmann, Matthias, Ecord, Michael, Egeland, Ricky, Eronen, Timo, Fry, Dan, Jones, Bailey H., Hellweg, Christine E., Houri, Jordan, Hirsh, Robert, Hirvonen, Mika, Hovland, Scott, Hussein, Hesham, Johnson, A. Steve, Kasemann, Moritz, Lee, Kerry, Leitgab, Martin, McLeod, Catherine, Milstein, Oren, Pinsky, Lawrence, Quinn, Phillip, Riihonen, Esa, Rohde, Markus, Rozhdestvenskyy, Sergiy, Saari, Jouni, Schram, Aaron, Straube, Ulrich, Turecek, Daniel, Virtanen, Pasi, Waterman, Gideon, Wheeler, Scott, Whitman, Kathryn, Wirtz, Michael, Vandewalle, Madelyn, Zeitlin, Cary, Semones, Edward, and Berger, Thomas
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- 2024
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31. Changes in Cannabis-Related Health Care Use in Alberta After Cannabis Legalization Between 2018 and 2022: A Population-Based Interrupted Time Series Study
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Pulok, Mohammad Habibullah, Patel, Nirav, Fry, Michelle, Friesen, Brent, Lang, Eddy, and Saini, Vineet
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- 2024
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32. The intergenerational metabolic-cardiovascular life course: maternal body mass index (BMI), offspring BMI, and blood pressure of adolescents born extremely preterm
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Sanderson, Keia, Oran, Ali, Singh, Rachana, Gogcu, Semsa, Perrin, Eliana M., Washburn, Lisa, Zhabotynsky, Vasyl, South, Andrew M., Jensen, Elizabeth T., Fry, Rebecca C., and O’Shea, T. Michael
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- 2024
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33. The use of Enhanced Vegetation Index for assessing access to different types of green space in epidemiological studies
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Mizen, Amy, Thompson, Daniel A., Watkins, Alan, Akbari, Ashley, Garrett, Joanne K., Geary, Rebecca, Lovell, Rebecca, Lyons, Ronan A., Nieuwenhuijsen, Mark, Parker, Sarah C., Rowney, Francis M., Song, Jiao, Stratton, Gareth, Wheeler, Benedict W., White, James, White, Mathew P., Williams, Sue, Rodgers, Sarah E., and Fry, Richard
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- 2024
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34. Proteomic aging clock predicts mortality and risk of common age-related diseases in diverse populations
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Argentieri, M. Austin, Xiao, Sihao, Bennett, Derrick, Winchester, Laura, Nevado-Holgado, Alejo J., Ghose, Upamanyu, Albukhari, Ashwag, Yao, Pang, Mazidi, Mohsen, Lv, Jun, Millwood, Iona, Fry, Hannah, Rodosthenous, Rodosthenis S., Partanen, Jukka, Zheng, Zhili, Kurki, Mitja, Daly, Mark J., Palotie, Aarno, Adams, Cassandra J., Li, Liming, Clarke, Robert, Amin, Najaf, Chen, Zhengming, and van Duijn, Cornelia M.
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- 2024
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35. Navigating tensions in climate change-related planned relocation
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Gini, Giovanna, Piggott-McKellar, Annah, Wiegel, Hanne, Neu, Friedrich Nikolaus, Link, Ann-Christine, Fry, Claudia, Tabe, Tammy, Adegun, Olumuyiwa, Wade, Cheikh Tidiane, Bower, Erica Rose, Koeltzow, Sarah, Harrington-Abrams, Rachel, Jacobs, Carolien, van der Geest, Kees, Zivdar, Narjes, Alaniz, Ryan, Cherop, Carolyne, Durand-Delacre, David, Pill, Melanie, Shekhar, Himanshu, Yates, Olivia, Khan, Md Abdul Awal, Nansam-Aggrey, Frank Kwesi, Grant, Lauren, Nizar, Danang Aditya, Owusu-Daaku, Kwame Nitri, Preato, Alberto, Stefancu, Oana, and Yee, Merewalesi
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- 2024
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36. Exploring Family Obligation as a Buffer Between Parental Differential Treatment and Sibling Hostility
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McClellan, Lucy S., Fry, Cassidy M., Telzer, Eva H., and Rogers, Christy R.
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- 2024
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37. Deep Confident Steps to New Pockets: Strategies for Docking Generalization
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Corso, Gabriele, Deng, Arthur, Fry, Benjamin, Polizzi, Nicholas, Barzilay, Regina, and Jaakkola, Tommi
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Quantitative Biology - Biomolecules ,Computer Science - Machine Learning - Abstract
Accurate blind docking has the potential to lead to new biological breakthroughs, but for this promise to be realized, docking methods must generalize well across the proteome. Existing benchmarks, however, fail to rigorously assess generalizability. Therefore, we develop DockGen, a new benchmark based on the ligand-binding domains of proteins, and we show that existing machine learning-based docking models have very weak generalization abilities. We carefully analyze the scaling laws of ML-based docking and show that, by scaling data and model size, as well as integrating synthetic data strategies, we are able to significantly increase the generalization capacity and set new state-of-the-art performance across benchmarks. Further, we propose Confidence Bootstrapping, a new training paradigm that solely relies on the interaction between diffusion and confidence models and exploits the multi-resolution generation process of diffusion models. We demonstrate that Confidence Bootstrapping significantly improves the ability of ML-based docking methods to dock to unseen protein classes, edging closer to accurate and generalizable blind docking methods.
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- 2024
38. Simulating decoherence of coupled two spin qubits using generalized cluster correlation expansion
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Chen, Xiao, Hoffman, Silas, Fry, James N., and Cheng, Hai-Ping
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Quantum Physics ,Physics - Computational Physics - Abstract
We study the coherence of two coupled spin qubits in the presence of a bath of nuclear spins simulated using generalized cluster correlation expansion (gCCE) method. In our model, two electron spin qubits coupled with isotropic exchange or magnetic dipolar interactions interact with an environment of random nuclear spins. We study the time-evolution of the two-qubit reduced density matrix (RDM) and resulting decay of the off diagonal elements, corresponding to decoherence, which allows us to calculate gate fidelity in the regime of pure dephasing. We contrast decoherence when the system undergoes free evolution and evolution with dynamical decoupling pulses applied. Moreover, we study the dependence of decoherence on external magnetic field and system parameters which mimic realistic spin qubits, emphasizing magnetic molecules. Lastly, we comment on the application and limitations of gCCE in simulating nuclear-spin induced two-qubit relaxation processes.
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- 2024
39. A Brauer--Galois height zero conjecture
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Malle, Gunter, Moretó, Alexander, Rizo, Noelia, and Fry, A. A. Schaeffer
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Mathematics - Representation Theory ,Mathematics - Group Theory ,20C15, 20C20, 20C33 - Abstract
Recently, Malle and Navarro obtained a Galois strengthening of Brauer's height zero conjecture for principal $p$-blocks when $p=2$, considering a particular Galois automorphism of order~$2$. In this paper, for any prime $p$ we consider a certain elementary abelian $p$-subgroup of the absolute Galois group and propose a Galois version of Brauer's height zero conjecture for principal $p$-blocks. We prove it when $p=2$ and also for arbitrary $p$ when $G$ does not involve certain groups of Lie type of small rank as composition factors. Furthermore, we prove it for almost simple groups and for $p$-solvable groups., Comment: a few minor improvements over version 1
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- 2024
40. On almost $p$-rational characters in principal blocks
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Maróti, Attila, Martínez, J. Miquel, Fry, A. A. Schaeffer, and Vallejo, Carolina
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Mathematics - Representation Theory ,Mathematics - Group Theory ,20C15, 20C20 - Abstract
Let p be a prime. In this paper we provide a lower bound for the number of almost p-rational characters of degree coprime to p in the principal p-block of a finite group of order divisible by p. We further describe the p-local structure of the groups for which the above-mentioned bound is sharp., Comment: To appear in Publicacions Matem\`atiques
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- 2024
41. Cross-Sectional Associations between Prenatal Per- and Poly-Fluoroalkyl Substances and Bioactive Lipids in Three Environmental Influences on Child Health Outcomes (ECHO) Cohorts
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Suthar, Himal, Manea, Tomás, Pak, Dominic, Woodbury, Megan, Eick, Stephanie M, Cathey, Amber, Watkins, Deborah J, Strakovsky, Rita S, Ryva, Brad A, Pennathur, Subramaniam, Zeng, Lixia, Weller, David, Park, June-Soo, Smith, Sabrina, DeMicco, Erin, Padula, Amy, Fry, Rebecca C, Mukherjee, Bhramar, Aguiar, Andrea, Geiger, Sarah Dee, Ng, Shukhan, Huerta-Montanez, Gredia, Vélez-Vega, Carmen, Rosario, Zaira, Cordero, Jose F, Zimmerman, Emily, Woodruff, Tracey J, Morello-Frosch, Rachel, Schantz, Susan L, Meeker, John D, Alshawabkeh, Akram N, Aung, Max T, and Outcomes, on behalf of Program Collaborators for Environmental Influences on Child Health
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Biomedical and Clinical Sciences ,Public Health ,Health Sciences ,Women's Health ,Pediatric ,Endocrine Disruptors ,Clinical Research ,Prevention ,Pregnancy ,Conditions Affecting the Embryonic and Fetal Periods ,2.1 Biological and endogenous factors ,Aetiology ,Reproductive health and childbirth ,Good Health and Well Being ,Humans ,Female ,Lipids ,Fluorocarbons ,Child Health ,Cohort Studies ,Cross-Sectional Studies ,Adult ,Environmental Pollutants ,Environmental Exposure ,Maternal Exposure ,Child ,PFAS ,mixtures ,bioactive lipids ,eicosanoids ,pregnancy outcomes ,inflammatory pathways ,metabolic pathways ,Program Collaborators for Environmental Influences on Child Health Outcomes ,Environmental Sciences - Abstract
Prenatal per- and poly-fluoroalkyl substances (PFAS) exposure may influence gestational outcomes through bioactive lipids─metabolic and inflammation pathway indicators. We estimated associations between prenatal PFAS exposure and bioactive lipids, measuring 12 serum PFAS and 50 plasma bioactive lipids in 414 pregnant women (median 17.4 weeks' gestation) from three Environmental influences on Child Health Outcomes Program cohorts. Pairwise association estimates across cohorts were obtained through linear mixed models and meta-analysis, adjusting the former for false discovery rates. Associations between the PFAS mixture and bioactive lipids were estimated using quantile g-computation. Pairwise analyses revealed bioactive lipid levels associated with PFDeA, PFNA, PFOA, and PFUdA (p < 0.05) across three enzymatic pathways (cyclooxygenase, cytochrome p450, lipoxygenase) in at least one combined cohort analysis, and PFOA and PFUdA (q < 0.2) in one linear mixed model. The strongest signature revealed doubling in PFOA corresponding with PGD2 (cyclooxygenase pathway; +24.3%, 95% CI: 7.3-43.9%) in the combined cohort. Mixture analysis revealed nine positive associations across all pathways with the PFAS mixture, the strongest signature indicating a quartile increase in the PFAS mixture associated with PGD2 (+34%, 95% CI: 8-66%), primarily driven by PFOS. Bioactive lipids emerged as prenatal PFAS exposure biomarkers, deepening insights into PFAS' influence on pregnancy outcomes.
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- 2024
42. Faster identification of faster Formula 1 drivers via time-rank duality
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Fry, John, Brighton, Tom, and Fanzon, Silvio
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Statistics - Applications ,Mathematics - Probability ,62P25, 91-10, 62M99, 65C05 - Abstract
Two natural ways of modelling Formula 1 race outcomes are a probabilistic approach, based on the exponential distribution, and econometric modelling of the ranks. Both approaches lead to exactly soluble race-winning probabilities. Equating race-winning probabilities leads to a set of equivalent parametrisations. This time-rank duality is attractive theoretically and leads to quicker ways of dis-entangling driver and car level effects., Comment: 9 pages
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- 2023
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43. Quantum Time Series Similarity Measures and Quantum Temporal Kernels
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Markov, Vanio, Rastunkov, Vladimir, and Fry, Daniel
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Quantum Physics - Abstract
This article presents a quantum computing approach to designing of similarity measures and kernels for classification of stochastic symbolic time series. In the area of machine learning, kernels are important components of various similarity-based classification, clustering, and regression algorithms. An effective strategy for devising problem-specific kernels is leveraging existing generative models of the example space. In this study we assume that a quantum generative model, known as quantum hidden Markov model (QHMM), describes the underlying distributions of the examples. The sequence structure and probability are determined by transitions within model's density operator space. Consequently, the QHMM defines a mapping from the example space into the broader quantum space of density operators. Sequence similarity is evaluated using divergence measures such as trace and Bures distances between quantum states. We conducted extensive simulations to explore the relationship between the distribution of kernel-estimated similarity and the dimensionality of the QHMMs Hilbert space. As anticipated, a higher dimension of the Hilbert space corresponds to greater sequence distances and a more distinct separation of the examples. To empirically evaluate the performance of the kernels, we defined classification tasks based on a simplified generative model of directional price movement in the stock market. We implemented two widely-used kernel-based algorithms - support vector machines and k-nearest neighbors - using both classical and quantum kernels. Across all classification task scenarios, the quantum kernels consistently demonstrated superior performance compared to their classical counterparts., Comment: 25 pages, 18 figures
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- 2023
44. A Method of Moments Approach to Asymptotically Unbiased Synthetic Controls
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Fry, Joseph
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Economics - Econometrics - Abstract
A common approach to constructing a Synthetic Control unit is to fit on the outcome variable and covariates in pre-treatment time periods, but it has been shown by Ferman and Pinto (2019) that this approach does not provide asymptotic unbiasedness when the fit is imperfect and the number of controls is fixed. Many related panel methods have a similar limitation when the number of units is fixed. I introduce and evaluate a new method in which the Synthetic Control is constructed using a General Method of Moments approach where units not being included in the Synthetic Control are used as instruments. I show that a Synthetic Control Estimator of this form will be asymptotically unbiased as the number of pre-treatment time periods goes to infinity, even when pre-treatment fit is imperfect and the number of units is fixed. Furthermore, if both the number of pre-treatment and post-treatment time periods go to infinity, then averages of treatment effects can be consistently estimated. I conduct simulations and an empirical application to compare the performance of this method with existing approaches in the literature.
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- 2023
45. Cognitive Tuning in the STEM Classroom: Communication Processes Supporting Children's Changing Conceptions about Data
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Kym Fry, Lyn English, and Katie Makar
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The teaching and learning of statistical thinking begins at a young age in Australia, with a focus on data representation and interpretation from Foundation Year (age 5), and the collection, sorting and categorising of items from the natural environment starting even earlier. The intangible concept of "data," as part of statistical literacy, can be complex for children to grasp, especially when applying the notion of data to the everyday world or when data are explored in isolation to an investigation process. Authentic data modelling experiences present meaningful opportunities to apply statistical thinking although expert STEM knowledge is not always accessible to primary classroom teachers, nor is it always obvious how to implement such authentic problems within a classroom context. In this exploratory case study, we present data from a Year 4 classroom (age 9) statistical investigation addressing, 'How big is a leaf?' linking data to the real-life STEM context they represented. The authors were interested in how the teacher's communication processes supported her students' emerging understandings about data. Wit's (2018) cognitive tuning framework offered a way to capture how the communication processes in a group build to a commonly shared frame of reference. Findings revealed a pattern of communication between the teacher and students, supporting students' changing conceptions of data and related statistical thinking processes, throughout the investigation.
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- 2024
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46. Community tuberculosis screening, testing and care, Uganda/ Depistage, analyse et prise en charge de la tuberculose au niveau communautaire en Ouganda/Deteccion, pruebas y atencion de la tuberculosis a nivel comunitario en Uganda
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Turyahabwe, Stavia, Bamuloba, Muzamiru, Mugenyi, Levicatus, Amanya, Geoffrey, Byaruhanga, Raymond, Imoko, Joseph Fry, Nakawooya, Mabel, Walusimbi, Simon, Nidoi, Jasper, Burua, Aldomoro, Sekadde, Moorine, Muttamba, Winters, Arinaitwe, Moses, Henry, Luzze, Kengonzi, Rose, Mudiope, Mary, and Kirenga, Bruce J.
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Lepers -- Analysis ,Tuberculosis -- Analysis ,Contact tracing -- Analysis ,Leprosy -- Analysis ,Health ,World Health Organization - Abstract
Objective To assess the effectiveness of a community-based tuberculosis and leprosy intervention in which village health teams and health workers conduct door-to-door tuberculosis screening, targeted screenings and contact tracing. Methods We conducted a before-and-after implementation study in Uganda to assess the effectiveness of the community tuberculosis intervention by looking at reach, outputs, adoption and effectiveness of the intervention. Campaign 1 was conducted in March 2022 and campaign 2 in September 2022. We calculated percentages of targets achieved and compared case notification rates during the intervention with corresponding quarters in the previous year. We also assessed the leprosy screening. Findings Over 5 days, campaign 1 screened 1 289 213 people (2.9% of the general population), of whom 179 144 (13.9%) fulfilled the presumptive tuberculosis criteria, and 4043 (2.3%) were diagnosed with bacteriologically-confirmed tuberculosis; 3710 (91.8%) individuals were linked to care. In campaign 2, 5 134 056 people (11.6% of the general population) were screened, detecting 428 444 (8.3%) presumptive tuberculosis patients and 8121 (1.9%) bacteriologically-confirmed tuberculosis patients; 5942 individuals (87.1%) were linked to care. The case notification rate increased from 48.1 to 59.5 per 100 000 population in campaign 1, with a case notification rate ratio of 1.24 (95% confidence interval, CI: 1.22-1.26). In campaign 2, the case notification rate increased from 45.0 to 71.6 per 100 000 population, with a case notification rate ratio of 1.59 (95% CI: 1.56-1.62). Of the 176 patients identified with leprosy, 137 (77.8%) initiated treatment. Conclusion This community tuberculosis screening initiative is effective. However, continuous monitoring and adaptations are needed to overcome context-specific implementation challenges. Objectif Evaluer l'efficacite d'une intervention de lutte contre la tuberculose et la lepre au niveau communautaire, dans le cadre de laquelle des equipes et agents de sante du village effectuent un depistage en porte-a-porte, des analyses ciblees et un suivi des contacts. Methodes Nous avons mene une etude en Ouganda, avant et apres la mise en reuvre, afin de mesurer les performances de cette intervention communautaire en examinant sa portee, ses resultats, son adoption et son efficacite. La campagne 1 s'est deroulee en mars 2022 et la campagne 2 en septembre 2022. Nous avons calcule les pourcentages d'objectifs atteints et compare le taux de signalement des cas durant l'intervention avec les trimestres correspondants de l'annee precedente. Nous avons egalement evalue le depistage de la lepre. Resultats En l'espace de cinq jours, la campagne 1 a passe en revue 1 289 213 personnes (2,9% de la population generale); parmi elles, 179 144 (13,9%) remplissaient les criteres d'une tuberculose presumee, 4043 (2,3%) ont regu un diagnostic de tuberculose avec confirmation bacteriologique et 3710 (91,8%) ont fait l'objet d'un suivi medical. Lors de la campagne 2, 5 134 056 personnes (11,6% de la population generale) ont fait l'objet d'un depistage; 428 444 (8,3%) cas presumes de tuberculose ont ete detectes et 8121 (1,9%) d'entre eux ont regu une confirmation bacteriologique, tandis que 5942 individus (87,1%) ont fait l'objet d'un suivi medical. De son cote, le taux de signalement des cas a augmente, passant de 48,1 a 59,5 par 100 000 habitants durant la campagne 1, ce qui equivaut a un rapport de taux de 1,24 (intervalle de confiance (IC) de 95%: 1,22-1,26). Et durant la campagne 2, le taux de signalement des cas a progresse de 45,0 a 71,6 par 100 000 habitants, avec un rapport de taux de 1,59 (IC de 95%: 1,56-1,62). Sur les 176 patients caracterises par un diagnostic de lepre, 137 (77,8%) ont entame un traitement. Conclusion Cette initiative de depistage communautaire s'est revelee efficace. Il est cependant necessaire d'exercer une surveillance continue et de proceder a des adaptations pour surmonter les difficultes de mise en reuvre liees au contexte. Objetivo Evaluar la eficacia de una intervencion comunitaria contra la tuberculosis y la lepra en la que los equipos y los profesionales sanitarios de los pueblos realizan pruebas de deteccion de la tuberculosis puerta a puerta, pruebas de deteccion selectivas y rastreo de contactos. Metodos Se realizo un estudio de implementacion antes y despues en Uganda para evaluar la eficacia de la intervencion comunitaria contra la tuberculosis mediante el analisis del alcance, los resultados, la adopcion y la eficacia de la intervencion. La campana 1 se llevo a cabo en marzo de 2022 y la campana 2 en septiembre de 2022. Se calcularon los porcentajes de objetivos alcanzados y se compararon las tasas de notificacion de casos durante la intervencion con los trimestres correspondientes del ano anterior.Ademas, se evaluo la deteccion de la lepra. Resultados Durante cinco dias, en la campana 1, se sometio a cribado a 1 289 213 personas (el 2,9% de la poblacion general), de las cuales 179 144 (el 13,9%) cumplian los criterios de presuncion de tuberculosis y a 4043 (el 2,3%) se les diagnostico tuberculosis confirmada bacteriologicamente; 3710 (el 91,8%) personas recibieron asistencia. En la campana 2, se sometio a cribado a 5 134 056 personas (11,6% de la poblacion general), detectandose 428 444 (8,3%) pacientes con tuberculosis presunta y 8121 (1,9%) con tuberculosis confirmada bacteriologicamente; 5942 personas (87,1%) recibieron asistencia. La tasa de notificacion de casos aumento de 48,1 a 59,5 por 100 000 habitantes en la campana 1, con una razon de tasa de notificacion de casos de 1,24 (intervalo de confianza del 95%, IC: 1,22-1,26). En la campana 2, la tasa de notificacion de casos aumento de 45,0 a 71,6 por 100 000 habitantes, con una razon de tasa de notificacion de casos de 1,59 (IC del 95%: 1,56-1,62). De los 176 pacientes identificados con lepra, 137 (77,8%) iniciaron tratamiento. Conclusion Esta iniciativa comunitaria de deteccion de la tuberculosis es eficaz. Sin embargo, se necesita un seguimiento continuo y adaptaciones para superar los desafios de implementacion especificos del contexto., Introduction Tuberculosis remains one of the leading causes of death worldwide. (1) In 2022, approximately 10.6 million people fell sick with tuberculosis globally, with most cases occurring in South-East Asia [...]
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- 2024
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47. Online Modules for Community-Engaged Learning during a Global Pandemic
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Lancaster, Alexander, Bonella, Barrett, Gesteland, Becky Jo, Tadlock, Patrick, and Fry, Richard
- Abstract
In the summer of 2020, our team created virtual community-engaged learning (VCEL) modules in response to the need to move classes to online and hybrid delivery styles during the height of the COVID-19 pandemic. These modules addressed engaged learning concepts and were designed with faculty, students, and community partner organizations in mind. This paper explores the challenges of creating and beta testing these VCEL modules, as well as the creative methods taken to produce high-quality content that would continue to serve students in the wake of the pandemic. What emerged from this project is a unique set of self-contained learning modules in Canvas Commons that include built-in assessments, allowing students to demonstrate learning, and allowing faculty members to review engaged-learning theory and strategies and integrate the virtual content into their online classes seamlessly. Our beta test findings indicate that students generally had a positive experience with the content and spent approximately two hours, on average, engaging with the material. In this reflective analysis of our process, we offer an explanation of the replicable process of creating VCEL modules and a description of the outcomes associated with producing and testing the content therein.
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- 2023
48. Assessment of knowledge, attitude, and use of complementary and integrative medicine among health-major students in Western Pennsylvania and their implications on ethics education
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Aramesh, Kiarash, Etemadi, Arash, Sines, Lindsay, Fry, Alayna, Coe, Taylor, and Tucker, Kaylan
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- 2024
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49. Targeting TGFβ-activated kinase-1 activation in microglia reduces CAR T immune effector cell-associated neurotoxicity syndrome
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Vinnakota, Janaki Manoja, Biavasco, Francesca, Schwabenland, Marius, Chhatbar, Chintan, Adams, Rachael C., Erny, Daniel, Duquesne, Sandra, El Khawanky, Nadia, Schmidt, Dominik, Fetsch, Viktor, Zähringer, Alexander, Salié, Henrike, Athanassopoulos, Dimitrios, Braun, Lukas M., Javorniczky, Nora R., Ho, Jenny N. H. G., Kierdorf, Katrin, Marks, Reinhard, Wäsch, Ralph, Simonetta, Federico, Andrieux, Geoffroy, Pfeifer, Dietmar, Monaco, Gianni, Capitini, Christian, Fry, Terry J., Blank, Thomas, Blazar, Bruce R., Wagner, Eva, Theobald, Matthias, Sommer, Clemens, Stelljes, Matthias, Reicherts, Christian, Jeibmann, Astrid, Schittenhelm, Jens, Monoranu, Camelia-Maria, Rosenwald, Andreas, Kortüm, Martin, Rasche, Leo, Einsele, Hermann, Meyer, Philipp T., Brumberg, Joachim, Völkl, Simon, Mackensen, Andreas, Coras, Roland, von Bergwelt-Baildon, Michael, Albert, Nathalie L., Bartos, Laura M., Brendel, Matthias, Holzgreve, Adrien, Mack, Matthias, Boerries, Melanie, Mackall, Crystal L., Duyster, Justus, Henneke, Philipp, Priller, Josef, Köhler, Natalie, Strübing, Felix, Bengsch, Bertram, Ruella, Marco, Subklewe, Marion, von Baumgarten, Louisa, Gill, Saar, Prinz, Marco, and Zeiser, Robert
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- 2024
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50. Ionospheric irregularities at Jupiter observed by JWST
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Melin, Henrik, O’Donoghue, J., Moore, L., Stallard, T. S., Fletcher, L. N., Roman, M. T., Harkett, J., King, O. R. T., Thomas, E. M., Wang, R., Tiranti, P. I., Knowles, K. L., de Pater, I., Fouchet, T., Fry, P. H., Wong, M. H., Holler, B. J., Hueso, R., James, M. K., Orton, G. S., Mura, A., Sánchez-Lavega, A., Lellouch, E., de Kleer, K., and Showalter, M. R.
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- 2024
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