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Observation is an essential tool for understanding and studying human behavior and mental states. However, coding human behavior is a time-consuming, expensive task, in which reliability can be difficult to achieve and bias is a risk. Machine learning (ML) methods offer ways to improve reliability, decrease cost, and scale up behavioral coding for application in clinical and research settings. Here, we use computer vision to derive behavioral codes or concepts of a gold standard behavioral rating system, offering familiar interpretation for mental health professionals. Features were extracted from videos of clinical diagnostic interviews of children and adolescents with and without obsessive-compulsive disorder. Our computationally-derived ratings were comparable to human expert ratings for negative emotions, activity-level/arousal and anxiety. For the attention and positive affect concepts, our ML ratings performed reasonably. However, results for gaze and vocalization indicate a need for improved data quality or additional data modalities., Comment: Presented at 2nd Workshop on Interpretable Machine Learning in Healthcare (IMLH) - International Conference on Machine Learning (ICML) 2022

Motivation: Behavioral observations are an important resource in the study and evaluation of psychological phenomena, but it is costly, time-consuming, and susceptible to bias. Thus, we aim to automate coding of human behavior for use in psychotherapy and research with the help of artificial intelligence (AI) tools. Here, we present an analysis plan. Methods: Videos of a gold-standard semi-structured diagnostic interview of 25 youth with obsessive-compulsive disorder (OCD) and 12 youth without a psychiatric diagnosis (no-OCD) will be analyzed. Youth were between 8 and 17 years old. Features from the videos will be extracted and used to compute ratings of behavior, which will be compared to ratings of behavior produced by mental health professionals trained to use a specific behavioral coding manual. We will test the effect of OCD diagnosis on the computationally-derived behavior ratings using multivariate analysis of variance (MANOVA). Using the generated features, a binary classification model will be built and used to classify OCD/no-OCD classes. Discussion: Here, we present a pre-defined plan for how data will be pre-processed, analyzed and presented in the publication of results and their interpretation. A challenge for the proposed study is that the AI approach will attempt to derive behavioral ratings based solely on vision, whereas humans use visual, paralinguistic and linguistic cues to rate behavior. Another challenge will be using machine learning models for body and facial movement detection trained primarily on adults and not on children. If the AI tools show promising results, this pre-registered analysis plan may help reduce interpretation bias. Trial registration: ClinicalTrials.gov - H-18010607, Comment: 7 pages, 1 figure