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1. Figure S3 from Larger Size of Donor Alloreactive NK Cell Repertoire Correlates with Better Response to NK Cell Immunotherapy in Elderly Acute Myeloid Leukemia Patients

Author

Curti, Antonio, primary, Ruggeri, Loredana, primary, Parisi, Sarah, primary, Bontadini, Andrea, primary, Dan, Elisa, primary, Motta, Maria Rosa, primary, Rizzi, Simonetta, primary, Trabanelli, Sara, primary, Ocadlikova, Darina, primary, Lecciso, Mariangela, primary, Giudice, Valeria, primary, Fruet, Fiorenza, primary, Urbani, Elena, primary, Papayannidis, Cristina, primary, Martinelli, Giovanni, primary, Bandini, Giuseppe, primary, Bonifazi, Francesca, primary, Lewis, Russell E., primary, Cavo, Michele, primary, Velardi, Andrea, primary, and Lemoli, Roberto M., primary

Published
2023
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2. Data from Larger Size of Donor Alloreactive NK Cell Repertoire Correlates with Better Response to NK Cell Immunotherapy in Elderly Acute Myeloid Leukemia Patients

Author

Curti, Antonio, primary, Ruggeri, Loredana, primary, Parisi, Sarah, primary, Bontadini, Andrea, primary, Dan, Elisa, primary, Motta, Maria Rosa, primary, Rizzi, Simonetta, primary, Trabanelli, Sara, primary, Ocadlikova, Darina, primary, Lecciso, Mariangela, primary, Giudice, Valeria, primary, Fruet, Fiorenza, primary, Urbani, Elena, primary, Papayannidis, Cristina, primary, Martinelli, Giovanni, primary, Bandini, Giuseppe, primary, Bonifazi, Francesca, primary, Lewis, Russell E., primary, Cavo, Michele, primary, Velardi, Andrea, primary, and Lemoli, Roberto M., primary

Published
2023
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3. supplemental figure legend from Larger Size of Donor Alloreactive NK Cell Repertoire Correlates with Better Response to NK Cell Immunotherapy in Elderly Acute Myeloid Leukemia Patients

Author

Curti, Antonio, primary, Ruggeri, Loredana, primary, Parisi, Sarah, primary, Bontadini, Andrea, primary, Dan, Elisa, primary, Motta, Maria Rosa, primary, Rizzi, Simonetta, primary, Trabanelli, Sara, primary, Ocadlikova, Darina, primary, Lecciso, Mariangela, primary, Giudice, Valeria, primary, Fruet, Fiorenza, primary, Urbani, Elena, primary, Papayannidis, Cristina, primary, Martinelli, Giovanni, primary, Bandini, Giuseppe, primary, Bonifazi, Francesca, primary, Lewis, Russell E., primary, Cavo, Michele, primary, Velardi, Andrea, primary, and Lemoli, Roberto M., primary

Published
2023
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4. Supplementary Tables S1 and S2 from Larger Size of Donor Alloreactive NK Cell Repertoire Correlates with Better Response to NK Cell Immunotherapy in Elderly Acute Myeloid Leukemia Patients

Author

Curti, Antonio, primary, Ruggeri, Loredana, primary, Parisi, Sarah, primary, Bontadini, Andrea, primary, Dan, Elisa, primary, Motta, Maria Rosa, primary, Rizzi, Simonetta, primary, Trabanelli, Sara, primary, Ocadlikova, Darina, primary, Lecciso, Mariangela, primary, Giudice, Valeria, primary, Fruet, Fiorenza, primary, Urbani, Elena, primary, Papayannidis, Cristina, primary, Martinelli, Giovanni, primary, Bandini, Giuseppe, primary, Bonifazi, Francesca, primary, Lewis, Russell E., primary, Cavo, Michele, primary, Velardi, Andrea, primary, and Lemoli, Roberto M., primary

Published
2023
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7. Allergy to latex

Author

Bandini, Giuseppe, Stanzani, Marta, Bonifazi, Francesca, Begliomini, Bruno, and Fruet, Fiorenza

Published
2000

9. Erroneous HLA typing as a result of acquired uniparental disomy in a patient with acute lymphoblastic leukaemia in peripheral blood complete remission

Author

Bontadini, Andrea, Iannelli, Sandra, Fruet, Fiorenza, Capelli, Simonetta, Masetti, Riccardo, Dubois, Valérie, Tiercy, Jean-Marie, Prete, Arcangelo, Bontadini, Andrea, Iannelli, Sandra, Fruet, Fiorenza, Capelli, Simonetta, Masetti, Riccardo, Dubois, Valérie, Tiercy, Jean-Marie, and Prete, Arcangelo

Subjects
Male, Comparative Genomic Hybridization, Sibling, acute lymphoblastic leukaemia, Siblings, Histocompatibility Testing, Gene Dosage, Loss of Heterozygosity, Case Report, loss of haplotype, Hematology, HLA-A3 Antigen, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Uniparental Disomy, Polymerase Chain Reaction, HLA typing, acquired uniparental disomy, Humans, Immunology and Allergy, Child, HLA-A1 Antigen, Human
Abstract

no abstract available

Published
2015

10. Larger Size of Donor Alloreactive NK Cell Repertoire Correlates with Better Response to NK Cell Immunotherapy in Elderly Acute Myeloid Leukemia Patients

Author

Curti, Antonio, primary, Ruggeri, Loredana, additional, Parisi, Sarah, additional, Bontadini, Andrea, additional, Dan, Elisa, additional, Motta, Maria Rosa, additional, Rizzi, Simonetta, additional, Trabanelli, Sara, additional, Ocadlikova, Darina, additional, Lecciso, Mariangela, additional, Giudice, Valeria, additional, Fruet, Fiorenza, additional, Urbani, Elena, additional, Papayannidis, Cristina, additional, Martinelli, Giovanni, additional, Bandini, Giuseppe, additional, Bonifazi, Francesca, additional, Lewis, Russell E., additional, Cavo, Michele, additional, Velardi, Andrea, additional, and Lemoli, Roberto M., additional

Published
2016
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11. Donor Natural Killer (NK) Alloreactivity Predicts Long-Term Relapse-Free Survival in Acute Myeloid Leukemia Patients Undergoing Immunotherapy with NK Cells

Author

Curti, Antonio, primary, Ruggeri, Loredana, additional, Parisi, Sarah, additional, Bontadini, Andrea, additional, Dan, Elisa, additional, Rizzi, Simonetta, additional, Motta, Maria Rosa, additional, Trabanelli, Sara, additional, Ocadlikova, Darina, additional, Lecciso, Mariangela, additional, Giudice, Valeria, additional, Urbani, Elena, additional, Papayannidis, Cristina, additional, Martinelli, Giovanni, additional, Bonifazi, Francesca, additional, Bandini, Giuseppe, additional, Fruet, Fiorenza, additional, Lewis, Russel E., additional, Cavo, Michele, additional, Velardi, Andrea, additional, and Lemoli, Roberto M., additional

Published
2014
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12. Occurrence of Fatal and Nonfatal Adverse Outcomes after Heart Transplantation in Patients with Pretransplant Noncytotoxic HLA Antibodies

Author

Potena, Luciano, primary, Bontadini, Andrea, additional, Iannelli, Sandra, additional, Fruet, Fiorenza, additional, Leone, Ornella, additional, Barberini, Francesco, additional, Borgese, Laura, additional, Manfredini, Valentina, additional, Masetti, Marco, additional, Magnani, Gaia, additional, Fallani, Francesco, additional, Grigioni, Francesco, additional, and Branzi, Angelo, additional

Published
2013
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13. Successful transfer of alloreactive haploidentical KIR ligand-mismatched natural killer cells after infusion in elderly high risk acute myeloid leukemia patients

Author

Curti, Antonio, primary, Ruggeri, Loredana, additional, D'Addio, Alessandra, additional, Bontadini, Andrea, additional, Dan, Elisa, additional, Motta, Maria Rosa, additional, Trabanelli, Sara, additional, Giudice, Valeria, additional, Urbani, Elena, additional, Martinelli, Giovanni, additional, Paolini, Stefania, additional, Fruet, Fiorenza, additional, Isidori, Alessandro, additional, Parisi, Sarah, additional, Bandini, Giuseppe, additional, Baccarani, Michele, additional, Velardi, Andrea, additional, and Lemoli, Roberto M., additional

Published
2011
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15. Adoptive Immunotherapy with Haploidentical Kir Ligand-Mismatched Natural Killer Cells In Elderly High Risk Acute Myeloid Leukemia Patients: Biological and Clinical Results of A Pilot Study

Author

Curti, Antonio, primary, Ruggeri, Loredana, additional, D'Addio, Alessandra, additional, Bontadini, Andrea, additional, Giudice, Valeria, additional, Dan, Elisa, additional, Motta, Maria Rosa, additional, Rizzi, Simonetta, additional, Trabanelli, Sara, additional, Urbani, Elena, additional, Martinelli, Giovanni, additional, Paolini, Stefania, additional, Fruet, Fiorenza, additional, Isidori, Alessandro, additional, Casadei, Beatrice, additional, Bandini, Giuseppe, additional, Baccarani, Michele, additional, Velardi, Andrea, additional, and Lemoli, Roberto M., additional

Published
2010
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16. Phase I-II Trial of Adoptive Immunotherapy with Haploidentical KIR Ligand-Mismatched Natural Killer Cells in High Risk Acute Myeloblastic Leukemia Patients.

Author

Curti, Antonio, primary, Ruggeri, Loredana, additional, D’Addio, Alessandra, additional, Urbani, Elena, additional, Bontadini, Andrea, additional, Fruet, Fiorenza, additional, Giudice, Valeria, additional, Dan, Elisa, additional, Motta, Maria Rosa, additional, Rizzi, Simona, additional, Paolini, Stefania, additional, Gugliotta, Gabriele, additional, Conte, Roberto, additional, Martinelli, Giovanni, additional, Velardi, Andrea, additional, Baccarani, Michele, additional, and Lemoli, Roberto M., additional

Published
2007
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18. Larger size of donor alloreactive NK cell repertoire correlates with better response to NK cell immunotherapy in elderly acute myeloid leukemia patients

Author

Mariangela Lecciso, Valeria Giudice, Maria Rosa Motta, Giuseppe Bandini, Loredana Ruggeri, Andrea Velardi, Russel Edward Lewis, Darina Očadlíková, Francesca Bonifazi, Sara Trabanelli, Simonetta Rizzi, Cristina Papayannidis, Andrea Bontadini, Roberto M. Lemoli, Giovanni Martinelli, Michele Cavo, Elena Urbani, Sarah Parisi, Elisa Dan, F. Fruet, Antonio Curti, Curti, Antonio, Ruggeri, Loredana, Parisi, Sarah, Bontadini, Andrea, Dan, Elisa, Motta, MARIA ROSA, Rizzi, Simonetta, Trabanelli, Sara, Ocadlikova, Darina, Lecciso, MARIANGELA STEFANIA, Giudice, Valeria, Fruet, Fiorenza, Urbani, Elena, Papayannidis, Cristina, Martinelli, Giovanni, Bandini, Giuseppe, Bonifazi, Francesca, Lewis, RUSSEL EDWARD, Cavo, Michele, Velardi, Andrea, and M. Lemoli, Roberto

Subjects
0301 basic medicine, Myeloid, Male, Isoantigens, Cancer Research, Oncology, medicine.medical_treatment, Age Factors, Aged, Combined Modality Therapy, Female, Genotype, Haplotypes, Histocompatibility Testing, Humans, Immunophenotyping, Killer Cells, Natural, Leukemia, Myeloid, Acute, Middle Aged, Phenotype, Prospective Studies, Receptors, KIR3DL1, Recurrence, Treatment Outcome, Immunotherapy, Tissue Donors, 0302 clinical medicine, Receptors, Killer Cells, Leukemia, Myeloid leukemia, Fludarabine, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Natural, medicine.drug, Cyclophosphamide, Acute, 03 medical and health sciences, KIR3DL1, medicine, business.industry, medicine.disease, Transplantation, 030104 developmental biology, Immunology, business
Abstract

In acute myeloid leukemia (AML), alloreactive natural killer (NK) cells are crucial mediators of immune responses after haploidentical stem cell transplantation. Allogeneic NK cell infusions have been adoptively transferred with promising clinical results. We aimed at determining whether the composition of NK graft in terms of frequency of alloreactive NK cells influence the clinical response in a group of elderly AML patients undergoing NK immunotherapy. Purpose: In acute myeloid leukemia (AML), alloreactive natural killer (NK) cells are crucial mediators of immune responses after haploidentical stem cell transplantation. Allogeneic NK cell infusions have been adoptively transferred with promising clinical results. We aimed at determining whether the composition of NK graft in terms of frequency of alloreactive NK cells influence the clinical response in a group of elderly AML patients undergoing NK immunotherapy. Experimental Design: Seventeen AML patients, in first complete remission (CR; median age 64 years, range 53-73) received NK cells from haploidentical KIR-ligand-mismatched donors after fludarabine/cyclophosphamide chemotherapy, followed by IL2. To correlate donor NK cell activity with clinical response, donor NK cells were assessed before and after infusion. Results: Toxicity was moderate, although 1 patient died due to bacterial pneumonia and was censored for clinical follow-up. With a median follow-up of 22.5 months (range, 6-68 months), 9 of 16 evaluable patients (0.56) are alive disease-free, whereas 7 of 16 (0.44) relapsed with a median time to relapse of 9 months (range, 3-51 months). All patients treated with molecular disease achieved molecular CR. A significantly higher number of donor alloreactive NK cell clones was observed in responders over nonresponders. The infusion of higher number of alloreactive NK cells was associated with prolonged disease-free survival (0.81 vs. 0.14, respectively; P = 0.03). Conclusions: Infusion of purified NK cells is feasible in elderly AML patients as post-CR consolidation strategy. The clinical efficacy of adoptively transferred haploidentical NK cells may be improved by infusing high numbers of alloreactive NK cells.

Published
2016

19. Occurrence of Fatal and Nonfatal Adverse Outcomes after Heart Transplantation in Patients with Pretransplant Noncytotoxic HLA Antibodies

Author

Angelo Branzi, S. Iannelli, F. Fruet, Luciano Potena, Marco Masetti, Gaia Magnani, Ornella Leone, V. Manfredini, Francesco Barberini, Andrea Bontadini, Francesco Grigioni, Francesco Fallani, L. Borgese, Potena, Luciano, Bontadini, Andrea, Iannelli, Sandra, Fruet, Fiorenza, Leone, Ornella, Barberini, Francesco, Borgese, Laura, Manfredini, Valentina, Masetti, Marco, Magnani, Gaia, Fallani, Francesco, Grigioni, Francesco, and Branzi, Angelo

Subjects
Heart transplantation, medicine.medical_specialty, biology, Article Subject, business.industry, medicine.medical_treatment, lcsh:Surgery, lcsh:RD1-811, Human leukocyte antigen, Gastroenterology, Antibodies, Internal medicine, Immunology, Clinical Study, Etiology, biology.protein, Medicine, Cytotoxic T cell, Clinical significance, Antibody, business, Pathological, Desensitization (medicine)
Abstract

HLA antibodies (HLA ab) in transplant candidates have been associated with poor outcome. However, clinical relevance of noncytotoxic antibodies after heart transplant (HT) is controversial. By using a Luminex-based HLA screening, we retested pretransplant sera from HT recipients testing negative for cytotoxic HLA ab and for prospective crossmatch. Out of the 173 consecutive patients assayed (52±13y; 16% females; 47% ischemic etiology), 32 (18%) showed pretransplant HLA ab, and 12 (7%) tested positive against both class I and class II HLA. Recipients with any HLA ab had poorer survival than those without (65±9versus82±3%;P=0.02), accounting for a doubled independent mortality risk (P=0.04). In addition, HLA-ab detection was associated with increased prevalence of early graft failure (35 versus 15%;P=0.05) and late cellular rejection (29 versus 11%;P=0.03). Of the subgroup of 37 patients suspected for antibody mediated rejection (AMR), the 9 with pretransplant HLA ab were more likely to display pathological AMR grade 2 (P=0.04). By an inexpensive, luminex-based, HLA-screening assay, we were able to detect non-cytotoxic HLA ab predicting fatal and nonfatal adverse outcomes after heart transplant. Allocation strategies and desensitization protocols need to be developed and prospectively tested in these patients.

Published
2013
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20. Erroneous HLA typing as a result of acquired uniparental disomy in a patient with acute lymphoblastic leukaemia in peripheral blood complete remission.

Author

Bontadini A, Iannelli S, Fruet F, Capelli S, Masetti R, Dubois V, Tiercy JM, and Prete A

Subjects
Child, Comparative Genomic Hybridization, Gene Dosage, HLA-A1 Antigen analysis, HLA-A1 Antigen genetics, HLA-A3 Antigen analysis, Humans, Male, Precursor Cell Lymphoblastic Leukemia-Lymphoma blood, Siblings, Uniparental Disomy genetics, HLA-A3 Antigen genetics, Histocompatibility Testing, Loss of Heterozygosity, Polymerase Chain Reaction methods, Precursor Cell Lymphoblastic Leukemia-Lymphoma immunology, Uniparental Disomy immunology
Published
2015
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