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3. Thoracic ultrasound combined with low-dose computed tomography may represent useful screening strategy in highly exposed population in the industrial city of Taranto (Italy)

Author

Quarato, Carla Maria Irene, primary, Dama, Elisa, additional, Maggi, Michele, additional, Feragalli, Beatrice, additional, Borelli, Cristina, additional, Del Colle, Anna, additional, Taurchini, Marco, additional, Maiello, Evaristo, additional, De Cosmo, Salvatore, additional, Lacedonia, Donato, additional, Barbaro, Maria Pia Foschino, additional, Carpagnano, Giovanna Elisiana, additional, Scioscia, Giulia, additional, Graziano, Paolo, additional, Termine, Rosalinda, additional, Frongillo, Elisabettamaria, additional, Santamaria, Sonia, additional, Venuti, Mariapia, additional, Grimaldi, Maria Arcangela, additional, Notarangelo, Stefano, additional, Saponara, Annarita, additional, Copetti, Massimiliano, additional, Colangelo, Tommaso, additional, Cuttano, Roberto, additional, Macrodimitris, Dimitrios, additional, Mazzarelli, Francesco, additional, Talia, Michela, additional, Mirijello, Antonio, additional, Pazienza, Luca, additional, Perna, Rita, additional, Simeone, Anna, additional, Vergara, Doriana, additional, Varriale, Antonio, additional, Carella, Massimo, additional, Bianchi, Fabrizio, additional, and Sperandeo, Marco, additional

Published
2023
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4. Thoracic ultrasound combined with low-dose computed tomography may represent useful screening strategy in highly exposed population in the industrial city of Taranto (Italy)

Author

Quarato, C, Dama, E, Maggi, M, Feragalli, B, Borelli, C, Del Colle, A, Taurchini, M, Maiello, E, De Cosmo, S, Lacedonia, D, Barbaro, M, Carpagnano, G, Scioscia, G, Graziano, P, Termine, R, Frongillo, E, Santamaria, S, Venuti, M, Grimaldi, M, Notarangelo, S, Saponara, A, Copetti, M, Colangelo, T, Cuttano, R, Macrodimitris, D, Mazzarelli, F, Talia, M, Mirijello, A, Pazienza, L, Perna, R, Simeone, A, Vergara, D, Varriale, A, Carella, M, Bianchi, F, Sperandeo, M, Quarato, Carla Maria Irene, Dama, Elisa, Maggi, Michele, Feragalli, Beatrice, Borelli, Cristina, Del Colle, Anna, Taurchini, Marco, Maiello, Evaristo, De Cosmo, Salvatore, Lacedonia, Donato, Barbaro, Maria Pia Foschino, Carpagnano, Giovanna Elisiana, Scioscia, Giulia, Graziano, Paolo, Termine, Rosalinda, Frongillo, Elisabettamaria, Santamaria, Sonia, Venuti, Mariapia, Grimaldi, Maria Arcangela, Notarangelo, Stefano, Saponara, Annarita, Copetti, Massimiliano, Colangelo, Tommaso, Cuttano, Roberto, Macrodimitris, Dimitrios, Mazzarelli, Francesco, Talia, Michela, Mirijello, Antonio, Pazienza, Luca, Perna, Rita, Simeone, Anna, Vergara, Doriana, Varriale, Antonio, Carella, Massimo, Bianchi, Fabrizio, Sperandeo, Marco, Quarato, C, Dama, E, Maggi, M, Feragalli, B, Borelli, C, Del Colle, A, Taurchini, M, Maiello, E, De Cosmo, S, Lacedonia, D, Barbaro, M, Carpagnano, G, Scioscia, G, Graziano, P, Termine, R, Frongillo, E, Santamaria, S, Venuti, M, Grimaldi, M, Notarangelo, S, Saponara, A, Copetti, M, Colangelo, T, Cuttano, R, Macrodimitris, D, Mazzarelli, F, Talia, M, Mirijello, A, Pazienza, L, Perna, R, Simeone, A, Vergara, D, Varriale, A, Carella, M, Bianchi, F, Sperandeo, M, Quarato, Carla Maria Irene, Dama, Elisa, Maggi, Michele, Feragalli, Beatrice, Borelli, Cristina, Del Colle, Anna, Taurchini, Marco, Maiello, Evaristo, De Cosmo, Salvatore, Lacedonia, Donato, Barbaro, Maria Pia Foschino, Carpagnano, Giovanna Elisiana, Scioscia, Giulia, Graziano, Paolo, Termine, Rosalinda, Frongillo, Elisabettamaria, Santamaria, Sonia, Venuti, Mariapia, Grimaldi, Maria Arcangela, Notarangelo, Stefano, Saponara, Annarita, Copetti, Massimiliano, Colangelo, Tommaso, Cuttano, Roberto, Macrodimitris, Dimitrios, Mazzarelli, Francesco, Talia, Michela, Mirijello, Antonio, Pazienza, Luca, Perna, Rita, Simeone, Anna, Vergara, Doriana, Varriale, Antonio, Carella, Massimo, Bianchi, Fabrizio, and Sperandeo, Marco

Abstract

Objectives: We validated a screening protocol in which thoracic ultrasound (TUS) acts as a first-line complementary imaging technique in selecting patients which may deserve a second-line low-dose high resolution computed tomography (HRCT) scan among a population of asymptomatic high-risk subjects for interstitial lung abnormalities (ILA) and lung cancer. Due to heavy environmental pollution burden, the district Tamburi of Taranto has been chosen as “case study” for this purpose. Methods: From July 2018 to October 2020, 677 patients aged between 45 and 65 year and who had been living in the Tamburi district of Taranto for at least 10 years were included in the study. After demographic, clinical and risk factor exposition data were collected, each participant underwent a complete TUS examination. These subjects were then asked to know if they agreed to perform a second-level examination by low-dose HRCT scan. Results: On a total of 167 subjects (24.7%) who agreed to undergo a second-level HRCT, 85 patients (50.9%) actually showed pleuro-pulmonary abnormalities. Interstitial abnormalities were detected in a total of 36 patients on HRCT scan. In particular, 34 participants presented subpleural ILAs, that were classified in the fibrotic subtype in 7 cases. The remaining 2 patients showed non-subpleural interstitial abnormalities. Subpleural nodules were observed in 46 patients. TUS showed an overall diagnostic accuracy of 88.6% in detecting pleuro-pulmonary abnormalities in comparison with HRCT scan, with a sensitivity of 95.3%, a specificity of 81.7%, a positive predictive value of 84.4% and a negative predictive value of 94.4%. The matched evaluation of specific pulmonary abnormalities on HRTC scan (i.e., interstitial abnormalities or pulmonary nodules) with determinate sonographic findings revealed a reduction in both TUS sensibility and specificity. Focusing TUS evaluation on the assessment of interstitial abnormalities, a thickened pleural line showed a sensitivity

Published
2023

7. Thoracic ultrasound combined with low-dose computed tomography may represent useful screening strategy in highly exposed population in the industrial city of Taranto (Italy)

Author

Quarato, Carla Maria Irene, Dama, Elisa, Maggi, Michele, Feragalli, Beatrice, Borelli, Cristina, Del Colle, Anna, Taurchini, Marco, Maiello, Evaristo, De Cosmo, Salvatore, Lacedonia, Donato, Barbaro, Maria Pia Foschino, Carpagnano, Giovanna Elisiana, Scioscia, Giulia, Graziano, Paolo, Termine, Rosalinda, Frongillo, Elisabettamaria, Santamaria, Sonia, Venuti, Mariapia, Grimaldi, Maria Arcangela, Notarangelo, Stefano, Saponara, Annarita, Copetti, Massimiliano, Colangelo, Tommaso, Cuttano, Roberto, Macrodimitris, Dimitrios, Mazzarelli, Francesco, Talia, Michela, Mirijello, Antonio, Pazienza, Luca, Perna, Rita, Simeone, Anna, Vergara, Doriana, Varriale, Antonio, Carella, Massimo, Bianchi, Fabrizio, Sperandeo, Marco, Quarato, C, Dama, E, Maggi, M, Feragalli, B, Borelli, C, Del Colle, A, Taurchini, M, Maiello, E, De Cosmo, S, Lacedonia, D, Barbaro, M, Carpagnano, G, Scioscia, G, Graziano, P, Termine, R, Frongillo, E, Santamaria, S, Venuti, M, Grimaldi, M, Notarangelo, S, Saponara, A, Copetti, M, Colangelo, T, Cuttano, R, Macrodimitris, D, Mazzarelli, F, Talia, M, Mirijello, A, Pazienza, L, Perna, R, Simeone, A, Vergara, D, Varriale, A, Carella, M, Bianchi, F, and Sperandeo, M

Subjects
ransthoracic ultrasound, high-resolution computed tomography, lung cancer, interstitial lung abnormalities, screening protocol, environmental exposure, lung cancer, interstitial lung abnormalities, high-resolution computed tomography, screening protocol, ransthoracic ultrasound, environmental exposure, transthoracic ultrasound, General Medicine, interstitial lung abnormalitie
Abstract

ObjectivesWe validated a screening protocol in which thoracic ultrasound (TUS) acts as a first-line complementary imaging technique in selecting patients which may deserve a second-line low-dose high resolution computed tomography (HRCT) scan among a population of asymptomatic high-risk subjects for interstitial lung abnormalities (ILA) and lung cancer. Due to heavy environmental pollution burden, the district Tamburi of Taranto has been chosen as “case study” for this purpose.MethodsFrom July 2018 to October 2020, 677 patients aged between 45 and 65 year and who had been living in the Tamburi district of Taranto for at least 10 years were included in the study. After demographic, clinical and risk factor exposition data were collected, each participant underwent a complete TUS examination. These subjects were then asked to know if they agreed to perform a second-level examination by low-dose HRCT scan.ResultsOn a total of 167 subjects (24.7%) who agreed to undergo a second-level HRCT, 85 patients (50.9%) actually showed pleuro-pulmonary abnormalities. Interstitial abnormalities were detected in a total of 36 patients on HRCT scan. In particular, 34 participants presented subpleural ILAs, that were classified in the fibrotic subtype in 7 cases. The remaining 2 patients showed non-subpleural interstitial abnormalities. Subpleural nodules were observed in 46 patients. TUS showed an overall diagnostic accuracy of 88.6% in detecting pleuro-pulmonary abnormalities in comparison with HRCT scan, with a sensitivity of 95.3%, a specificity of 81.7%, a positive predictive value of 84.4% and a negative predictive value of 94.4%. The matched evaluation of specific pulmonary abnormalities on HRTC scan (i.e., interstitial abnormalities or pulmonary nodules) with determinate sonographic findings revealed a reduction in both TUS sensibility and specificity. Focusing TUS evaluation on the assessment of interstitial abnormalities, a thickened pleural line showed a sensitivity of 63.9% and a specificity of 69.5%, hypoechoic striae showed a sensitivity of 38.9% and a specificity of 90.1% and subpleural nodules showed a sensitivity of 58.3% and a specificity of 77.1%. Regarding to the assessment of subpleural nodules, TUS showed a sensitivity of 60.9% and a specificity of 81.0%. However, the combined employment of TUS examination and HRCT scans allowed to identify 34 patients with early subpleural ILA and to detect three suspicious pulmonary nodules (of which two were intraparenchymal and one was a large subpleural mass), which revealed to be lung cancers on further investigations.ConclusionA first-line TUS examination might aid the identification of subjects highly exposed to environmental pollution, who could benefit of a second-line low-dose HRCT scan to find early interstitial lung diseases as well as lung cancer.Protocol registration codePLEURO-SCREENING-V1.0_15 Feb, 17.

Published
2023

9. Safety and accuracy of transthoracic ultrasound-guided fine-needle aspiration biopsy

Author

Frongillo, Elisabettamaria, Tinti, Maria, Dimitri, Lucia, and Sperandeo, Marco

Subjects
Health
Abstract

Byline: Elisabettamaria. Frongillo, Maria. Tinti, Lucia. Dimitri, Marco. Sperandeo Sir, We read with great interest the review by Abdelfattah Ahmed Touman et al .,[1] recently published in your journal, focused [...]

Published
2018

11. Transthoracic ultrasound sign in severe asthmatic patients: a lack of “gliding sign” mimic pneumothorax

Author

Del Colle, Anna, primary, Carpagnano, Giovanna Elisiana, additional, Feragalli, Beatrice, additional, Foschino Barbaro, Maria Pia, additional, Lacedonia, Donato, additional, Scioscia, Giulia, additional, Quarato, Carla Maria Irene, additional, Buonamico, Enrico, additional, Tinti, Maria Giulia, additional, Rea, Gaetano, additional, Cipriani, Cristiana, additional, Frongillo, Elisabettamaria, additional, De Cosmo, Salvatore, additional, Guglielmi, Giuseppe, additional, and Sperandeo, Marco, additional

Published
2019
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22. Count of B-lines: a reappraisal. Comment on "Visual versus automatic ultrasound scoring of lung B-lines: reliability and consistency between systems".

Author

Irene Quarato, Carla Maria, Lacedonia, Donato, Colle, Anna Del, Gaudiuso, Giulia, Frongillo, Elisabettamaria, Cipriani, Cristiana, Tinti, Maria Giulia, Sperandeo, Marco, Quarato, Carla Maria Irene, and Del Colle, Anna

Subjects
*ULTRASONIC imaging, *MEDICAL artifacts, *AUTOMATION, *LUNGS, RESEARCH evaluation
Abstract

. [ABSTRACT FROM AUTHOR]

Published
2019
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24. Transthoracic ultrasound sign in severe asthmatic patients: a lack of "gliding sign" mimic pneumothorax.

Author

Del Colle A, Carpagnano GE, Feragalli B, Foschino Barbaro MP, Lacedonia D, Scioscia G, Quarato CMI, Buonamico E, Tinti MG, Rea G, Cipriani C, Frongillo E, De Cosmo S, Guglielmi G, and Sperandeo M

Abstract

Transthoracic ultrasound (TUS) is a validate complementary technique widely used in everyday medical practice. TUS is the gold-standard for studying pleural effusion and for echo-guided thoracentesis, moreover, it is employed in detection of pleural and pulmonary lesions adherent to pleural surface and their ccho-guided percutaneous needle biopsy (PTNB). 1 We used TUS technique to study severe asthma patients. We found that several patterns are constant in these patients. One of these patterns, i.e . lack of gliding sign, mimic pneumothorax (PNX). In this study, we attempted an echographic approach to asthma, trying to lay the first stone for the individuation of common ultrasound patterns in this disease., (© 2019 The Authors. Published by the British Institute of Radiology.)

Published
2019
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