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629 results on '"Frommeyer G"'

2. Triggered activity in atrial myocytes is influenced by Na+/Ca2+ exchanger activity in genetically altered mice

Author

Bögeholz, N, Pauls, P, Kaese, S, Schulte, JS, Lemoine, MD, Dechering, DG, Frommeyer, G, Goldhaber, JI, Seidl, MD, Kirchhefer, U, Eckardt, L, Müller, FU, and Pott, C

Subjects
Medical Physiology, Biomedical and Clinical Sciences, Heart Disease, Cardiovascular, Action Potentials, Animals, Calcium, Calcium Signaling, Female, Gene Expression, Heart Atria, Male, Membrane Potentials, Mice, Mice, Transgenic, Myocardial Contraction, Myocardium, Myocytes, Cardiac, Sarcoplasmic Reticulum, Sodium-Calcium Exchanger, Na+/Ca2+ exchanger, Afterdepolarizations, Atrial fibrillation, Atrial myocytes, Na(+)/Ca(2+) exchanger, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Biochemistry and cell biology, Cardiovascular medicine and haematology, Medical physiology
Abstract

AimsIn atrial fibrillation, increased function of the Na+/Ca2+-exchanger (NCX) is one among several electrical remodeling mechanisms.Methods/resultsUsing the patch-clamp- and Ca2+ imaging-methods, we investigated atrial myocytes from NCX-homozygous-overexpressor (OE)- and heterozygous-knockout (KO)-mice and their corresponding wildtypes (WTOE; WTKO). NCX mediated Ca2+ extrusion capacity was reduced in KO and increased in OE. There was no evidence for structural or molecular remodeling. During a proarrhythmic pacing-protocol, the number of low amplitude delayed afterdepolarizations (DADs) was unaltered in OE vs. WTOE and KO vs. WTKO. However, DADs triggered full spontaneous action potentials (sAP) significantly more often in OE vs. WTOE (ratio sAP/DAD: OE:0.18±0.05; WTOE:0.02±0.02; p

Published
2016

11. The new ESC guidelines on the management of ventricular tachyarrhythmias Implications for daily practice

Author

Konemann, H., Frommeyer, G., Zeppenfeld, K., and Eckardt, L.

Subjects
Sudden cardiac death, Ventricular arrhythmias, Ventricular tachycardia, Catheter ablation, Implantable cardioverter defibrillators
Abstract

The recently published guidelines of the European Society of Cardiology (ESC) on the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death is an update of the 2015 guideline. For the first time a new section is dedicated to public basic life support. In the acute treatment of ventricular arrhythmias electrical cardioversion is upgraded, and there is a new focus on the management of electrical storm. Recommendations for the comprehensive diagnostic evaluation of patients with first manifestations of ventricular arrhythmias structured according to common clinical scenarios are also new. Both genetic testing and cardiac magnetic resonance imaging are upgraded, not only for diagnostic evaluation but also for risk stratification. In the long-term management, recommendations for pharmacotherapy are aligned with current heart failure guidelines. Catheter ablation has gained relevance not only for recurrent ventricular tachycardia under amiodarone treatment and as an alternative to implantable cardioverter defibrillation (ICD) implantation in selected patients with coronary artery disease but also particularly in the treatment of idiopathic ventricular extrasystoles and tachycardia. The ICD treatment remains an essential component of primary and secondary prevention of sudden cardiac death. Of note, the recommendation on primary preventive ICD treatment for patients with dilated cardiomyopathy and left ventricular ejection fraction (LVEF)

Published
2022

22. EKG-Quiz

Author

Bauersachs, J., Borggrefe, M., Eckardt, L., Ehlermann, P., Engberding, R., Frommeyer, G., Fabritz, L., Friedrich, C., Gerecke, B., Herrera-Siklody, C., Katus, H. A., Kirchhof, P., McKenna, W. J., Oswald, H., Paul, M., Parade, U., Pott, C., Rüb, N., Schimpf, R., Seebohm, G., Schulze-Bahr, E., Sen-Chowdhry, Srijita, Stallmeyer, B., Strotmann, C., Tomé Esteban, M. T., Veltmann, C., Waltenberger, J., Wichter, T., Wolpert, C., and Zumhagen, S.

Published
2012
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