116 results on '"Frolich, Marijke"'
Search Results
2. Sensitivity to activated protein C during the menstrual cycle in women with and without factor V Leiden
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van Vliet, Huib A.A.M., Rodrigues, Sharon P., Snieders, Marieke N.E., van der Meer, Felix J.M., Frolich, Marijke, Rosendaal, Frits R., Rosing, Jan, and Helmerhorst, Frans M.
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- 2008
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3. Systemic energy homeostasis in Huntington's disease patients
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Aziz, N. Ahmad, Pijl, Hanno, Frolich, Marijke, Snel, Marieke, Streefland, Trea C.M., Roelfsema, Ferdinand, and Roos, Raymund A.C.
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Huntington's chorea -- Development and progression ,Huntington's chorea -- Genetic aspects ,Huntington's chorea -- Research ,Homeostasis -- Demographic aspects ,Homeostasis -- Genetic aspects ,Homeostasis -- Research ,Bioenergetics -- Demographic aspects ,Bioenergetics -- Genetic aspects ,Bioenergetics -- Research ,Energy metabolism -- Demographic aspects ,Energy metabolism -- Genetic aspects ,Energy metabolism -- Research ,Health ,Psychology and mental health - Published
- 2010
4. Low serum free triiodothyronine levels mark familial longevity: the Leiden Longevity Study
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Rozing, Maarten P., Westendorp, Rudi G.J., de Craen, Anton J.M., Frolich, Marijke, Heijmans, Bastiaan T., Beekman, Marian, Wijsman, Carolien, Mooijaart, Simon P., Blauw, Gerard-Jan, Slagboom, P. Eline, and van Heemst, Diana
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Longevity -- Research ,Thyrotropin -- Physiological aspects ,Thyrotropin -- Research ,Thyroxine -- Physiological aspects ,Thyroxine -- Research ,Health ,Seniors - Abstract
Background. The hypothalamo-pituitary-thyroid axis has been widely implicated in modulating the aging process. Life extension effects associated with low thyroid hormone levels have been reported in multiple animal models. In human populations, an association was observed between low thyroid function and longevity at old age, but the beneficial effects of low thyroid hormone metabolism at middle age remain elusive. Methods. We have compared serum thyroid hormone function parameters in a group of middle-aged offspring of long-living nonagenarian siblings and a control group of their partners, all participants of the Leiden Longevity Study. Results. When compared with their partners, the group of offspring of nonagenarian siblings showed a trend toward higher serum thyrotropin levels (1.65 vs 157 mU/L, p =.11) in conjunction with lower free thyroxine levels (15.0 vs 15.2 pmol/L, p = .045) and lower free triiodothyronine levels (4.08 vs 4.14 pmol/L, p = .024). Conclusions. Compared with their partners, the group of offspring of nonagenarian siblings show a lower thyroidal sensitivity to thyrotropin. These findings suggest that the favorable role of low thyroid hormone metabolism on health and longevity in model organism is applicable to humans as well. Key Words: Thyroid--Longevity--Endocrinology. doi: 10.1093/gerona/glp200
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- 2010
5. Pituitary-hormone secretion by thyrotropinomas
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Roelfsema, Ferdinand, Kok, Simon, Kok, Petra, Pereira, Alberto M., Biermasz, Nienke R., Smit, Jan W., Frolich, Marijke, Keenan, Daniel M., Veldhuis, Johannes D., and Romijn, Johannes A.
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- 2009
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6. Vascular factors and markers of inflammation in offspring with a parental history of late-onset Alzheimer disease
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van Exel, Eric, Eikelenboom, Piet, Comijs, Hannie, Frolich, Marijke, Smit, Johannes H., Stek, Max L., Scheltens, Philip, Eefsting, Jan E., and Westendorp, Rudi G.J.
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Alzheimer's disease -- Development and progression ,Alzheimer's disease -- Research ,Amyloid beta-protein -- Physiological aspects ,Amyloid beta-protein -- Research ,Health ,Psychology and mental health - Published
- 2009
7. Is nephrocalcinosis in preterm neonates harmful for long-term blood pressure and renal function?
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Kist-van Holthe, Joana E., van Zwieten, Paul H.T., Schell-Feith, Eveline A., Zonderland, Harmien M., Holscher, Herma C., Wolterbeek, Ron, Veen, Sylvia, Frolich, Marijke, and van der Heijden, Bert J.
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Lung diseases -- Research ,Lung diseases -- Care and treatment ,Lung diseases -- Complications and side effects ,Lung diseases -- Analysis ,Infants (Premature) -- Diseases ,Infants (Premature) -- Complications and side effects ,Infants (Premature) -- Health aspects - Abstract
OBJECTIVE. The aim of our study was to examine long-term effects of nephrocalcinosis in prematurely born children. PATIENTS AND METHODS. Preterm neonates (gestational age RESULTS. Blood pressure did not differ in ex-preterm infants with and without nephrocalcinosis but was significantly higher than expected for healthy children. In comparison to healthy children, more ex-preterm infants with neonatal nephrocalcinosis had (mild) chronic renal insufficiency (glomerular filtration rate: CONCLUSIONS. Nephrocalcinosis in preterm neonates can have long-term sequelae for glomerular and tubular function. Furthermore, prematurity per se is associated with high blood pressure, relatively small kidneys, and (distal) tubular dysfunction. Long-term follow-up of blood pressure and renal glomerular and tubular function of preterm neonates, especially with neonatal nephrocalcinosis, seems warranted., NEPHROCALCINOSIS, FIRST DESCRIBED in preterm neonates in 1982 by Hufnagle, was initially attributed to long-term furosemide therapy for chronic lung disease. (1) Since then, nephrocalcinosis was diagnosed in 7% to [...]
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- 2007
8. Activation of dopamine D2 receptors simultaneously ameliorates various metabolic features of obese women
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Kok, Petra, Roelfsema, Ferdinand, Frolich, Marijke, van Pelt, Johannes, Stokkel, Marcel P.M., Meinders, A. Edo, and Pijl, Hanno
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Metabolic syndrome X -- Research ,Metabolic syndrome X -- Health aspects ,Insulin resistance -- Research ,Prolactin -- Research ,Overweight persons -- Health aspects ,Overweight persons -- Research ,Women -- Health aspects ,Women -- Physiological aspects ,Biological sciences - Abstract
The metabolic syndrome comprises a cluster of metabolic anomalies including insulin resistance, abdominal obesity, dyslipidemia, and hypertension. Previous studies suggest that impaired dopamine D2 receptor (D2R) signaling is involved in its pathogenesis. We studied the acute effects of bromocriptine (a D2R agonist) on energy metabolism in obese women; body weight and caloric intake remained constant. Eighteen healthy, obese women (BMI 33.2 [+ or -] 0.6 kg/[m.sup.2], mean age 37.5 [+ or -] 1.7, range 22-51 yr) were studied twice in the follicular phase of their menstrual cycle in a prospective, single-blind, crossover design. Subjects received both placebo (P; always first occasion) and bromocriptine (B; always second occasion) on separate occasions for 8 days. At each occasion blood glucose and insulin were assessed every 10 min for 24 h, and circadian plasma free fatty acid (FFA) and triglyceride (TG) levels were measured hourly. Fuel oxidation was determined by indirect calorimetry. Body weight and composition were not affected by the drug. Mean 24-h blood glucose (P < 0.01) and insulin (P < 0.01) were significantly reduced by bromocriptine, whereas mean 24 h FFA levels were increased (P < 0.01), suggesting that lipolysis was stimulated. Bromocriptine increased oxygen consumption (P = 0.03) and resting energy expenditure (by 50 kcal/day, P = 0.03). Systolic blood pressure was significantly reduced by bromocriptine. Thus these results imply that short-term bromocriptine treatment ameliorates various components of the metabolic syndrome while it shifts energy balance away from lipogenesis in obese humans. metabolic syndrome; food intake; insulin resistance; d2r agonist; prolactin
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- 2006
9. Increased circadian prolactin release is blunted after body weight loss in obese premenopausal women
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Kok, Petra, Roelfsema, Ferdinand, Langendonk, Janneke G., de Wit, Caroline C., Frolich, Marijke, Burggraaf, Jacobus, Meinders, A. Edo, and Pijl, Hanno
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Menopause -- Health aspects ,Weight loss -- Health aspects ,Prolactin -- Health aspects ,Biological sciences - Abstract
We recently showed that prolactin (PRL) release is considerably enhanced in obese women in proportion to the size of their visceral fat mass. PRL release is inhibited by dopamine 2 receptor (D2R) activation, and dietary restriction/weight loss are associated with increased dopaminergic signaling in animals. Therefore, we hypothesized that enhanced PRL release in obese humans would be reversed by weight loss. To evaluate this postulate, we measured 24-h plasma PRL concentrations at 10-min intervals in 11 obese premenopausal women (BMI 33.3 [+ or -] 0.7 kg/[m.sup.2]) before and after weight loss (50% reduction of overweight/ 15% absolute weight loss, using a very low-calorie diet) in the follicular phase of their menstrual cycle. The 24-h PRL concentration profiles were analyzed by a peak detection program (Cluster) and a wave form-independent deconvolution technique (Pulse). Spontaneous 24-h PRL secretion was significantly reduced in obese women [mean daily release, before 128 [+ or -] 24 vs. after weight loss 110 [+ or -] 17 [micro]g/liter distribution volume [(Vdl).sup.-1] X 24 h, P = 0.05]. Body weight loss particularly blunted PRL secretory burst mass (Pulse area, before 230 [+ or -] 28 vs. after weight loss 221 [+ or -] 31 [micro]g/[Vd1.sup.-1] x 24 h, P = 0.03), whereas burst frequency was unaffected (no. of pulses, before 11 [+ or -] 1 vs. after weight loss 12 [+ or -] 1 n/24 h, P = 0.69). Thus elevated PRL secretion rate in obese women is significantly reduced after loss of 50% of overweight. We speculate that amelioration of deficit D2Rmediated neurotransmission and/or diminutions of circulating leptin/estrogen levels might be involved in the physiology of this phenomenon. caloric restriction; estrogen; dopamine; leptin
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- 2006
10. Is blood pressure increased 19 years after intrauterine growth restriction and preterm birth? A prospective follow-up study in the Netherlands
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Keijzer-Veen, Mandy G., Finken, Martijn J.J., Nauta, Jeroen, Dekker, Friedo W., Hille, Elysee T.M., Frolich, Marijke, Wit, Jan M., and van der Heijden, A.J.
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Premature labor -- Case studies ,Blood pressure -- Case studies ,Infants (Premature) -- Case studies ,Family and marriage ,Health - Abstract
Objective. To determine whether intrauterine growth restriction (IUGR) is a predisposing factor for high blood pressure (BP) in 19-year-olds who were born (very) preterm. Methods. A prospective follow-up study was conducted at age 19 in individuals who born preterm in the Netherlands in 1983. Systolic, diastolic, and mean BP values and plasma renin activity concentration were obtained in 422 young adults who were born with a gestational age (GA) Results. An increased prevalence of hypertension and probably also of prehypertensive stage was found. IUGR, birth weight, GA, and plasma renin activity were not associated with BP. Current weight and BMI were the best predicting factors for systolic BP at the age of 19 years. Conclusions. The prevalence of hypertension is high in individuals who were born preterm when compared with the general population. In the individuals who were born very preterm, no support to the hypothesis that low birth weight is associated with increased BP at young adult age can be given. Pediatrics 2005;116:725-731; adulthood, blood pressure, follow-up studies, intrauterine growth retardation, preterm infants., ABBREVIATIONS. IUGR, intrauterine growth restriction; BP, blood pressure; GA, gestational age; SBP, systolic blood pressure; SDS, SD score; DBP, diastolic blood pressure; PRA, plasma renin activity; MAP, mean arterial pressure; [...]
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- 2005
11. Altered setting of the pituitary-thyroid ensemble in hypocretin-deficient narcoleptic men
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Kok, Simon W., Roelfsema, Ferdinand, Overeem, Sebastiaan, Lammers, Gert Jan, Frolich, Marijke, Meinders, A. Edo, and Pijl, Hanno
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Neural transmission -- Complications and side effects ,Thyrotropin -- Risk factors ,Narcolepsy -- Causes of ,Biological sciences - Abstract
Narcolepsy is a sleep disorder caused by disruption of hypocretin (orexin) neurotransmission. Injection of hypocretin-1 acutely suppresses TRH and TSH release in rats. In contrast, subchronic administration does not appear to affect the hypothalamo-pituitary-thyroid ensemble in animals. We explored (in 7 patients and 7 controls) whether hypocretin deficiency impacts circulating TSH levels and circadian timing of TSH release in narcoleptic humans. Plasma TSH concentration profiles (blood samples taken at 10-min intervals during 24 h) and TSH levels in response to TRH injection were analyzed by Cluster, robust regression, approximate entropy (ApEn), and deconvolution. Circulating TSH levels were lower in patients, which was primarily attributable to lower pulse amplitude and nadir concentrations. TSH secretion correlated positively with mean 24-h leptin levels ([R.sup.2] = 0.46, P = 0.02) and negatively with amount of sleep ([R.sup.2] = 0.29, P = 0.048). Pattern-synchrony between 24-h leptin and TSH concentrations was demonstrated by significant cross-correlation and cross-ApEn analyses with no differences between controls and patients. Sleep onset was closely associated with a fall in circulating TSH. Features of diurnal rhythmicity of circulating TSH fluctuations were similar in patients and controls, with the acrophase occurring shortly after midnight. Thyroxine and triiodothyronine concentrations were similar in patients and controls and did not display a diurnal rhythm. The response of plasma TSH levels to TRH was also similar in both groups. Sleep patterns in narcoleptics were significantly disorderly compared with controls, as measured by ApEn (P = 0.006). In summary, circulating TSH concentrations are low in hypocretin-deficient narcoleptic men, which could be attributable to their low plasma leptin levels and/or their abnormal sleep-wake cycle. narcolepsy; thyroid-stimulating hormone; orexin; sleep; entropy
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- 2005
12. Growth hormone secretion in primary adrenal Cushing's syndrome is disorderly and inversely correlated with body mass index
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van Aken, Maarten O., Pereira, Alberto M., Frolich, Marijke, Romijn, Johannes A., Pijl, Hanno, Veldhuis, Johannes D., and Roelfsema, Ferdinand
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Adenoma -- Causes of ,Body mass index -- Analysis ,Biological sciences - Abstract
To evaluate the impact on the somatotropic axis of endogenous cortisol excess in the absence of primary pituitary disease, we investigated spontaneous 24-h growth hormone (GH) secretion in 12 adult patients with ACTH-independent hypercortisolism. Plasma GH concentration profiles (10-min samples) were analyzed by deconvolution to reconstruct secretion and approximate entropy to quantitate orderliness of the release process. Comparisons were made with a body mass index (BMI)-, age-, and gender-matched control group and an age- and gender-matched lean control group. GH secretion rates did not differ from BMI-matched controls but were twofold lower compared with lean subjects, mainly due to a 2.5-fold attenuation of the mean secretory burst mass (P = 0.001). In hypercortisolemic patients, GH secretion was negatively correlated with BMI (R = -0.55, P = 0.005) but not cortisol secretion. Total serum IGF-I concentrations were similar in the three groups. Approximate entropy (ApEn) was increased in patients with Cushing's syndrome compared with both control groups (vs. BMI-matched, P = 0.04; vs. lean, P = 0.001), denoting more irregular GH secretion patterns. ApEn in patients correlated directly with cortisol secretion (R = 0.77, P = 0.003). Synchrony between cortisol and GH concentration series was analyzed by cross-correlation, cross-ApEn, and copulsatility analyses. Patients showed loss of pattern synchrony compared with BMImatched controls, but copulsatility was unchanged. We conclude that hyposomatotropism in primary adrenal hypercortisolism is only partly explained (~30%) by increased body weight and that increased GH secretory irregularity and loss of synchrony suggest altered coordinate regulation of GH release. cortisol; entropy; adrenal adenoma
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- 2005
13. Thyroid status, disability and cognitive function, and survival in old age
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Gussekloo, Jacobijn, Exel, Eric van, Craen, Anton J.M. de, Meinders, Arend E., Frolich, Marijke, and Westendorp, Rudi G.J.
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Thyroid diseases -- Care and treatment ,Thyroid diseases -- Research ,Thyroxine -- Dosage and administration - Abstract
A prospective, observational, population-based follow-up study is conducted to determine whether subclinical thyroid dysfunction should be treated in old age and the long-term impact of thyroid dysfunction on performance and survive in old age. The findings indicate that the plasma levels of thyrotropin and free thyroxine are not associated with disability in daily life, depressive symptoms and cognitive impairment at baseline.
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- 2004
14. Enhanced circadian ACTH release in obese premenopausal women: reversal by short-term acipimox treatment
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Kok, Petra, Kok, Simon W., Buijs, Madelon M., Westenberg, Jos J.M., Roelfsema, Ferdinand, Frolich, Marijke, Stokkel, Marcel P.M., Meinders, A. Edo, and Pijl, Hanno
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Hormones -- Research ,Obesity -- Research ,Biological sciences - Abstract
Enhanced circadian ACTH release in obese premenopausal women: reversal by short-term acipimox treatment. Am J Physiol Endocrinol Metab 287: E848-E856, 2004. First published July 27, 2004; doi:10.1152/ ajpendo.00254.2004.--Several studies suggest that the hypothalamopituitary-adrenal (HPA) axis is exceedingly active in obese individuals. Experimental studies show that circulating free fatty acids (FFAs) promote the secretory activity of the HPA axis and that human obesity is associated with high circulating FFAs. We hypothesized that HPA axis activity is enhanced and that lowering of circulating FFAs by acipimox would reduce spontaneous secretion of the HPA hormonal ensemble in obese humans. To evaluate these hypotheses, diurnal ACTH and cortisol secretion was studied in 11 obese and 9 lean premenopausal women (body mass index: obese 33.5 [+ or -] 0.9 vs. lean 21.2 [+ or -] 0.6 kg/[m.sup.2], P < 0.001) in the early follicular stage of their menstrual cycle. Obese women were randomly assigned to treatment with either acipimox (inhibitor of lipolysis, 250 mg orally four times daily) or placebo in a double-blind crossover design, starting one day before admission until the end of the blood-sampling period. Blood samples were taken during 24 h with a sampling interval of 10 min for assessment of plasma ACTH and cortisol concentrations. ACTH and cortisol secretion rates were estimated by multiparameter deconvolution analysis. Daily ACTH secretion was substantially higher in obese than in lean women (7,950 [+ or -] 1,212 vs. 2,808 [+ or -] 329 ng/24 h, P = 0.002), whereas cortisol was not altered (obese 36,362 [+ or -] 5,639 vs. lean 37,187 [+ or -] 4,239 nmol/24 h, P = 0.912). Acipimox significantly reduced ACTH secretion in the obese subjects (acipimox 5,850 [+ or -] 769 ng/24 h, P = 0.039 vs. placebo), whereas cortisol release did not change (acipimox 33,542 [+ or -] 3,436 nmol/24 h, P = 0.484 vs. placebo). In conclusion, spontaneous ACTH secretion is enhanced in obese premenopausal women, whereas cortisol production is normal. Reduction of circulating FFA concentrations by acipimox blunts ACTH release in obese women, which suggests that FFAs are involved in the pathophysiology of this neuroendocrine anomaly. adrenocorticotropic hormone; spontaneous secretion; pituitary adrenal system; free fatty acids; obesity
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- 2004
15. Acipimox enhances spontaneous growth hormone secretion in obese women
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Kok, Petra, Buijs, Madelon M., Kok, Simon W., van Ierssel, H.A.P., Frolich, Marijke, Roelfsema, Ferdinand, Voshol, Peter J., Meinders, A. Edo, and Pijl, Hanno
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Obesity -- Research ,Biological sciences - Abstract
Kok, Petra, Madelon M. Buijs, Simon W. Kok, Inge H. A. P. van Ierssel, Marijke Frolich, Ferdinand Roelfsema, Peter J. Voshol, A. Edo Meinders, and Hanno Pijl. Acipimox enhances spontaneous growth hormone secretion in obese women. Am J Physiol Regul Integr Comp Physiol 286: R693-R698, 2004. First published December 11, 2003; 10.1152/ajpregu.00595.2003.--We hypothesized that a high circulating free fatty acid (FFA) concentration is involved in the pathogenesis of hyposomatotropism associated with obesity. To evaluate this hypothesis, 10 healthy premenopausal women (body mass index 33.8 [+ or -] 1.0 kg/[m.sup.2]) were studied in the follicular phase of their menstrual cycle at two occasions with a time interval of at least 8 wk, where body weight remained stable. Subjects were randomly assigned to treatment with either acipimox (an inhibitor of lipolysis, 250 mg orally 4 times daily) or placebo in a double-blind crossover design, starting 1 day before admission until the end of the blood sampling period. Blood samples were taken during 24 h with a sampling interval of 10 min for assessment of growth hormone (GH) concentrations, and GH secretion was estimated by deconvolution analysis. Identical methodology was used to study GH secretion in a historical control group of age-matched normal weight women. GH secretion was clearly blunted in obese women (total daily release 66 [+ or -] 10 vs. lean controls: 201 [+ or -] 23 mU * [[l.sub.Vd].sup.-1] * 24 [h.sup.-1], P = 0.005, where [l.sub.Vd] is liter of distribution volume). Acipimox considerably enhanced total (113 [+ or -] 50 vs. 66 [+or -] 10 mU * [[l.sub.Vd].sup.-1] * 24[h.sup.-1], P = 0.02) and pulsatile GH secretion (109 [+ or -] 49 vs. 62 [+ or -] 30 mU * [[l.sub.Vd].sup.-1] * 24 [h.sup.-1], P = 0.02), but GH output remained lower compared with lean controls. Further analysis did not show any relationship between the effects of acipimox on GH secretion and regional body fat distribution. In conclusion, acipimox unleashes spontaneous GH secretion in obese women. It specifically enhances GH secretory burst mass. This might mean that lowering of systemic FFA concentrations by acipimox modulates neuroendocrine mechanisms that orchestrate the activity of the somatotropic ensemble. hyposomatotropism; growth hormone kinetics; somatotroph cell function; free fatty acid
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- 2004
16. Retention of estradiol negative feedback relationship to LH predicts ovulation in response to caloric restriction and weight loss in obese patients with polycystic ovary syndrome
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van Dam, Eveline W.C.M., Roelfsema, Ferdinand, Veldhuis, Johannes D., Hogendoorn, Simone, Westenberg, Jos, Helmerhorst, Frans M., Frolich, Marijke, Krans, H. Michiel, J., Meinders, A. Edo, and Pijl, Hanno
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Estradiol -- Research ,Biological sciences - Abstract
Van Dam, Eveline W. C. M., Ferdinand Roelfsema, Johannes D. Veldhuis, Simone Hogendoorn, Jos Westenberg, Frans M. Helmerhorst, Marijke Frolich, H. Michiel J. Krans, A. Edo Meinders, and Hanno Pijl. Retention of estradiol negative feedback relationship to LH predicts ovulation in response to caloric restriction and weight loss in obese patients with polycystic ovary syndrome. Am J Physiol Endocrinol Metab 286: E615-E620, 2004. First published December 16, 2003; 10.1152/ajpendo.00377.2003.--The present study tests the hypothesis that specific endocrine, metabolic, and anthropometric features distinguish obese women with polycystic ovary syndrome (PCOS) who resume ovulation in response to calorie restriction and weight loss from those who do not. Fifteen obese (body mass index 39 [+ or -] 7 kg/[m.sup.2]) hyperandrogenemic oligoovulatory patients undertook a very low calorie diet (VLCD), wherein each lost [greater than or equal to] 10% of body weight over a mean of 6.25 mo. Body fat distribution was quantitated by magnetic resonance imaging. Hormones were measured in the morning at baseline, after 1 wk of VLCD, and after 10% weight loss. To monitor LH release, blood was sampled for 24 h at 10-min intervals before intervention and after 7 days of VLCD. Responders were defined a priori as individuals exhibiting two or more ovulatory cycles in the course of intervention, as corroborated by serum progesterone concentrations [greater than or equal to] 18 nmol/l followed by vaginal bleeding. At baseline, responders had a higher sex hormone-binding globulin (SHBG) concentration but were otherwise indistinguishable from nonresponders. Body weight, the size of body fat depots, and plasma insulin levels declined to a similar extent in responders and nonresponders. Also, SHBG increased, and the free testosterone index decreased comparably. However, responders exhibited a significant decline of circulating estradiol concentrations (from 191 [+ or -] 82 to 158 [+ or -] 77 pmol/l, means [+ or -] SD, P = 0.037) and a concurrent increase in LH secretion (from 104 = [+ or -] 42 to 140 [+ or -] 5 U*[1.sup.-1]*[day.sup.-1], P = 0.006) in response to 7 days of VLCD, whereas neither parameter changed significantly in nonresponders. We infer that evidence of retention of estradiol-dependent negative feedback on LH secretion may forecast follicle maturation and ovulation in obese patients with PCOS under dietary restriction. fertility; ovarian cycle; sex hormones; body fat distribution; gonadotropins
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- 2004
17. Octreotide represses secretory-burst mass and nonpulsatile secretion but does not restore event frequency or orderly GH secretion in acromegaly
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Biermasz, Nienke R., Pereira, Alberto M., Frolich, Marijke, Romijn, Johannes A., Veldhuis, Johannes D., and Roelfsema, Ferdinand
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Somatostatin -- Research ,Biological sciences - Abstract
Octreotide is a potent somatostatin analog that inhibits growth hormone (GH) release and restricts somatotrope cell growth. The long-acting octreotide formulation Sandostatin LAR is effective clinically in ~60% of patients with acromegaly. Tumoral GH secretion in this disorder is characterized by increases in pulse amplitude and frequency, nonpulsatile (basal) release, and irregularity. Whether sustained blockade by octreotide can restore physiological secretion patterns in this setting is unknown. To address this question, we studied seven patients with GH-secreting tumors during chronic receptor agonism. Responses were monitored by sampling blood at 10-min intervals for 24 h, followed by analyses of secretion and regularity by multiparameter deconvolution and approximate entropy (ApEn). The somatostatin agonist suppressed GH secretory-burst mass, nonpulsatile (basal) GH release, and pulsatile secretion, thereby decreasing total GH secretion by 86% (range 70-96%). ApEn decreased from 1.203 [+ or -] 0.129 to 0.804 [+ or -] 0.141 (P = 0.032), denoting greater regularity. None of GH pulse frequency, basal GH secretion rates, or ApEn normalized. In summary, chronic somatostatin agonism is able to repress amplitude-dependent measures of excessive GH secretion in acromegaly. Presumptive tumoral autonomy is inferred by continued elevations of event frequency, overall pattern disruption (irregularity), and nonsuppressible basal GH secretion. growth hormone; human; deconvolution analysis; diurnal rhythm
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- 2004
18. Somatotropic axis in hypocretin-deficient narcoleptic humans: altered circadian distribution of GH-secretory events
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Overeem, Sebastiaan, Kok, Simon W., Lammers, Gert Jan, Vein, Alla A., Frolich, Marijke, Meinders, Arend E., Roelfsema, Ferdinand, and Pijl, Hanno
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Physiology -- Research ,Narcolepsy -- Physiological aspects ,Somatotropin -- Physiological aspects ,Biological sciences - Abstract
Narcolepsy is a sleep disorder caused by impaired hypocretin (orexin) neurotransmission. Growth hormone (GH) secretion may be altered in narcolepsy for various reasons. Slow-wave sleep episodes, which are closely associated with GH-secretory events, are more randomly dispersed over 24 h in narcoleptics. Furthermore, hypocretins may inhibit pituitary GH release. We assessed the function of the somatotropic axis in narcolepsy by deconvolving 24-h (10-min sampling interval) plasma GH concentration profiles in seven hypocretin-deficient narcoleptic patients and in seven healthy controls matched for age, sex, and body weight. Both basal and pulsatile GH secretion rate and secretagogue-induced GH release were similar in patients and controls. However, narcoleptics secreted ~50% of their total production during the daytime, whereas controls secreted only 25% during the day. Also, the GH output pattern of narcoleptics was significantly less regular. We propose that hypocretin deficiency disrupts the circadian distribution of hypothalamic GH-releasing hormone release in narcoleptic patients to simultaneously cause daytime GH release and promote their propensity to fall asleep during the day. orexin; diurnal; deconvolution
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- 2003
19. Increase in daily LH secretion in response to short-term calorie restriction in obese women with PCOS
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Van Dam, Eveline W.C.M., Roelfsema, Ferdinand, Veldhuis, Johannes D., Helmerhorst, Frans M., Frolich, Marijke, Meinders, A. Edo, Krans, H. Michiel J., and Pijl, Hanno
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Physiology -- Research ,Stein-Leventhal syndrome -- Physiological aspects ,Luteinizing hormone -- Physiological aspects ,Leptin -- Physiological aspects ,Insulin -- Physiological aspects ,Diet therapy -- Usage ,Biological sciences - Abstract
We hypothesized that short-term calorie restriction would blunt luteinizing hormone (LH) hypersecretion in obese women with polycystic ovary syndrome (PCOS) and thereby ameliorate the anovulatory endocrine milieu. To test this hypothesis, 15 obese patients with PCOS and nine age- and body mass index-matched healthy women underwent 24-h blood sampling to quantitate plasma LH, leptin, and insulin levels. PCOS subjects were prescribed a very low caloric liquid diet (4.2 MJ/day) for 7 days and were then resampled. Basal and pulsatile LH secretion was threefold higher in PCOS subjects, but plasma insulin and leptin levels were not different in the calorie-replete state. Contrary to expectation, calorie restriction enhanced basal and pulsatile LH secretion even further. As expected, plasma glucose, insulin, and leptin concentrations decreased by 18, 75, and 50%, respectively. Serum total testosterone concentration fell by 23%, whereas serum estrone, estradiol, sex hormone-binding globulin (SHBG), and androstenedione concentrations remained unchanged. Enhanced LH secretion in the presence of normal metabolic and hormonal adaptations to calorie restriction points to anomalous feedback control of pituitary LH release in PCOS. leptin; insulin; dietary intervention; feedback regulation
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- 2002
20. Genetic Architecture of Plasma Adiponectin Overlaps With the Genetics of Metabolic Syndrome–Related Traits
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Henneman, Peter, Aulchenko, Yurii S., Frants, Rune R., Zorkoltseva, Irina V., Zillikens, M. Carola, Frolich, Marijke, Oostra, Ben A., van Dijk, Ko Willems, and van Duijn, Cornelia M.
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- 2010
- Full Text
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21. Disordered and Increased Adrenocorticotropin Secretion with Diminished Adrenocorticotropin Potency in Obese in Premenopausal Women
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Roelfsema, Ferdinand, Kok, Petra, Frolich, Marijke, Pereira, Alberto M., and Pijl, Hanno
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- 2009
22. Diminished and Irregular Thyrotropin Secretion with Preserved Diurnal Rhythm in Patients with Active Acromegaly
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Roelfsema, Ferdinand, Biermasz, Nienke R., Frolich, Marijke, Keenan, Daniel M., Veldhuis, Johannes D., and Romijn, Johannes A.
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- 2009
23. Vitamin B12 and folate and the risk of anemia in old age: The Leiden 85-plus study
- Author
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den Elzen, Wendy P.J., Westendorp, Rudi G.J., Frolich, Marijke, de Ruijter, Wouter, Assendelft, Willem J.J., and Gussekloo, Jacobijn
- Subjects
Vitamin B12 -- Research ,Folic acid -- Research ,Anemia -- Risk factors ,Anemia -- Demographic aspects ,Anemia -- Research ,Health - Published
- 2008
24. Effect of hyperinsulinemia on plasma leptin concentrations and food intake in rats
- Author
-
Koopmans, Sietse J., Frolich, Marijke, Gribnau, Eric H., Westendorp, Rudi G.J., and DeFronzo, Ralph A.
- Subjects
Leptin -- Research ,Ingestion -- Research ,Insulin -- Physiological aspects ,Biological sciences - Abstract
Research was conducted to examine the effect of hyperinsulinemia on plasma leptin concentrations and food intake in male Sprague-Dawley rats. Doses of insulin were administered for times ranging from 2 h to 7 days on plasma leptin levels and food intake. The euglycemic insulin clamp method was used in awake unstressed rats to analyze the effect of hyperinsulinemia while maintaining strict euglycemia. The role of leptin in food consumption is supported by the observed inverse relationship between food intake and plasma leptin concentration during prolonged hyperinsulinemia.
- Published
- 1998
25. Anti-inflammatory cytokine profile and mortality in febrile patients
- Author
-
Dissel, Jaap T. van, Langevelde, Petra van, Westendorp, Rudi G.J., Kwappenberg, Kitty, and Frolich, Marijke
- Subjects
Interleukin-10 -- Physiological aspects ,Tumor necrosis factor -- Physiological aspects ,Bacterial infections -- Physiological aspects ,Fever -- Physiological aspects ,Inflammation -- Mediators - Published
- 1998
26. Anti-inflammatory cytokine profile and mortality in febrile patients
- Author
-
Van Dissel, Jaap T., Van Langevelde, Petra, Westendorp, Rudi GJ, Kwappenberg, Kitty, and Frolich, Marijke
- Published
- 1998
27. Short-term caloric restriction induces accumulation of myocardial triglycerides and decreases left ventricular diastolic function in healthy subjects
- Author
-
van der Meer, Rutger W., Hammer, Sebastiaan, Smit, Johannes W.A., Frolich, Marijke, Bax, Jeroen J., Diamant, Michaela, Rijzewijk, Luuk J., de Roos, Albert, Romijn, Johannes A., and Lamb, Hildo J.
- Subjects
Heart beat -- Health aspects -- Research ,Low-calorie diet -- Health aspects -- Research ,Triglycerides -- Health aspects -- Research ,Health ,Research ,Health aspects - Abstract
OBJECTIVE--Diabetes and obesity are associated with increased plasma nonesterified fatty acid (NEFA) levels, myocardial triglyceride accumulation, and myocardial dysfunction. Because a very low-calorie diet (VLCD) also increases plasma NEFA levels, [...]
- Published
- 2007
28. Central obesity is an independent risk factor for albuminuria in nondiabetic South Asian subjects
- Author
-
Chandie Shaw, Prataap K., Berger, Stefan P., Mallat, Marko, Frolich, Marijke, Dekker, Friedo W., and Rabelink, Ton J.
- Subjects
Obesity -- Complications and side effects -- Research -- Risk factors ,South Asians -- Health aspects -- Research ,Kidney failure -- Risk factors -- Complications and side effects -- Research ,Albuminuria -- Risk factors -- Complications and side effects -- Research ,Health ,Complications and side effects ,Research ,Risk factors ,Health aspects - Abstract
OBJECTIVE--South Asians have a high prevalence of central obesity. When the diagnosis of diabetes is made, they have a very high risk of developing renal failure. In the current study, [...]
- Published
- 2007
29. Association between sex hormone-binding globulin levels and activated protein C resistance in explaining the risk of thrombosis in users of oral contraceptives containing different progestogens
- Author
-
van Vliet, Huib A.A.M., Frolich, Marijke, Christella, M., Thomassen, L.G.D., Doggen, Carine J.M., Rosendaal, Frits R., Rosing, Jan, and Helmerhorst, Frans M.
- Published
- 2005
30. Effect of peptide YY on pancreatico-biliary secretion in humans
- Author
-
SYMERSKY, TOMAS, BIEMOND, IZAK, FROLICH, MARIJKE, and MASCLEE, AD A. M.
- Published
- 2005
31. Homocysteine, vitamin B-12, and folic acid and the risk of cognitive decline in old age: the Leiden 85-Plus Study
- Author
-
Mooijaart, Simon P., Gussekloo, Jacobijn, Frolich, Marijke, Jelle Jolles, Stott, David J., Westendorp, Rudi G.J., and de Craen, Anton J.M.
- Subjects
Aged -- Psychological aspects ,Cognition disorders -- Risk factors ,Homocysteine -- Health aspects ,Vitamin B -- Health aspects ,Vitamin B complex -- Health aspects ,Folic acid -- Health aspects ,Food/cooking/nutrition ,Health - Abstract
Background: High concentrations of homocysteine and low concentrations of vitamin B- 12 and folic acid are frequently observed in subjects with dementia. Objective: We assessed whether serum concentrations of homocysteine, vitamin B- 12, or folic acid predict cognitive decline in old age. Design: This was a prospective, population-based, longitudinal study of 599 subjects (Leiden 85-Plus Study, Netherlands). The subjects were administered a battery of cognitive tests (including the Mini Mental State Examination, the Stroop test, a letter digit coding test, and a word recall test) at 85 y of age and yearly thereafter until 89 y of age. Serum concentrations of homocysteine, vitamin B- 12, and folic acid were measured at 85 and 89 y of age. Cross-sectional associations between serum concentrations and cognition were assessed at 85 and 89 y of age. The association between baseline serum concentrations and subsequent longitudinal cognitive decline was assessed with the use of mixed linear models. Results: In the cross-sectional analyses, serum concentrations of homocysteine and folic acid were significantly associated with cognitive performance, but serum concentrations of vitamin B-l 2 were not. In the longitudinal analyses, there were no significant associations of serum concentrations of homocysteine, vitamin B-12, or folic acid with rate of cognitive decline. Conclusions: Elevated serum concentrations of homocysteine and reduced folic acid are associated with cognitive impairment in elderly persons hut do not predict an increased rate of cognitive decline. The association of high serum concentrations of homocysteine and low folic acid with cognitive impairment in old age is likely to be a consequence of disease and not a contributory cause. KEY WORDS Homocysteine, folic acid, vitamin B-12, elderly persons, cognitive decline
- Published
- 2005
32. Blunted lipolytic response to fasting in abdominally obese women: evidence for involvement of hyposomatotropism
- Author
-
Buijs, Madelon M, Burggraaf, Jacobus, Wijbrandts, Carla, de Kam, Marieke L, Frolich, Marijke, Cohen, Adam F, Romijn, Johannes A, Sauerwein, Hans P, Meinders, A Edo, and Pijl, Hanno
- Subjects
Fasting -- Physiological aspects ,Lipolysis -- Measurement ,Obesity -- Physiological aspects ,Lipid metabolism -- Physiological aspects ,Food/cooking/nutrition ,Health - Abstract
Background: Abdominal obesity is associated with a blunted lipolytic response to fasting that may contribute to the preservation of adipose tissue mass. Objective: To further explore the pathophysiology of blunted lipolysis during fasting in obesity, we simultaneously measured lipolysis and distinct neuroendocrine regulatory hormones in abdominally obese and normal-weight (NW) women. Design: Eight abdominally obese [bar]x [+ or -] SD body mass index (BMI; in kg/[m.sup.2]): 32.1 [+ or -] 2.6] and 6 NW (BMI: 22.7 [+ or -] 1.5) women were studied during the last 8 h of a 20-h fast. The glycerol appearance rate and the serum and plasma concentrations of insulin, leptin, cortisol, and growth hormone were measured regularly. Results: At 13 h of fasting, the mean ([+ or -] SD) glycerol appearance rate corrected for fat mass was greater in NW women than in obese women (7.2 [+ or -] 1.0 and 5.1 [+ or -] 0.6 [micro]mol*[kg.sup.-2]*[min.sup.-1], respectively; P = 0.001). After a 20-h fast, lipolysis increased to 8.9 [+ or -] 1.5 mmol*[kg.sup.-2]*[min.sup.-1] in NW women (23%), whereas it did not change significantly in obese women (-2%). Fasting decreased insulin concentrations by [approximately equal to] 30% in both groups, but it did not induce significant changes in leptin concentrations. Mean cortisol concentrations and urinary catecholamine excretion were comparable in both groups. However, mean plasma growth hormone concentrations were higher in NW women than in obese women (1.81 [+ or -] 0.98 compared with 0.74 [+ or -] 0.52 mU/L; P = 0.046). The relative change in lipolysis tended to correlate with mean plasma growth hormone concentrations (r = 0.515, P = 0.059). Conclusion: Abdominal obesity-associated hyposomatotropism may be involved in the blunted increase in lipolysis during fasting. KEY WORDS Lipid metabolism, somatotropin, starvation, lipolysis rate, obesity, women
- Published
- 2003
33. Low production capacity of interleukin-10 associates with the metabolic syndrome and type 2 diabetes: the Leiden 85-plus study
- Author
-
van Exel, Eric, Gussekloo, Jacobijn, de Craen, Anton J.M., Frolich, Marijke, Bootsma-van der Wiel, Annetje, and Westendorp, Rudi G.J.
- Subjects
Lipids -- Physiological aspects -- Health aspects ,Cytokines -- Genetic aspects -- Physiological aspects -- Health aspects ,Metabolism -- Physiological aspects -- Genetic aspects -- Health aspects ,Aged -- Health aspects -- Physiological aspects ,Dextrose -- Physiological aspects -- Health aspects -- Genetic aspects ,Blood lipoproteins -- Physiological aspects -- Genetic aspects -- Health aspects ,Proteolipids -- Physiological aspects -- Genetic aspects -- Health aspects ,Interleukin-10 -- Physiological aspects -- Health aspects ,Glucose -- Physiological aspects -- Health aspects -- Genetic aspects ,Lipoproteins -- Physiological aspects -- Genetic aspects -- Health aspects ,Type 2 diabetes -- Physiological aspects -- Genetic aspects ,Health ,Physiological aspects ,Genetic aspects ,Health aspects - Abstract
It has been suggested that the metabolic syndrome and type 2 diabetes are manifestations of the inflammatory host response. This host response is orchestrated by the production of pro- and [...]
- Published
- 2002
34. Effect of duodenum-preserving resection of the head of the pancreas on endocrine and exocrine pancreatic function in patients with chronic pancreatitis
- Author
-
Eddes, Eric H., Masclee, Ad A.M., Gooszen, Hein G., Frolich, Marijke, and Lamers, Cornelis B.H.W.
- Subjects
Pancreatitis -- Care and treatment ,Pancreas ,Health - Abstract
BACKGROUND: Chronic pancreatitis leads to progressive destruction of pancreatic parenchyma affecting exocrine and endocrine function. We prospectively evaluated the effect of duodenum-preserving resection of the head of the pancreas on pancreatic function. METHODS: Exocrine and endocrine function were measured in a combined test including (1) urinary PABA recovery; (2) plasma glucose, glycogen, and C-peptide responses; and (3) plasma pancreatic polypeptide response. Nineteen patients were included. RESULTS: Compared with the preoperative state, plasma glucose levels did not increase postoperatively. Plasma C-peptide levels were reduced postoperatively but the difference was not significant. The percentage of insulin-dependent patients did not increase after operation (32% versus 32%). Glucose tolerance improved in 4 patients and deteriorated in 3 patients. Postoperative basal and-meal stimulated plasma pancreatic polypeptide levels were significantly reduced. Postoperative urinary PABA recovery was not significantly different from preoperative values. CONCLUSIONS: Neither exocrine nor endocrine pancreatic function are negatively influenced by duodenum-preserving pancreatic head resection. Am J Surg. 1997; 174:387-392. [C] 1997 by Excerpta Medica, Inc.
- Published
- 1997
35. Nitric oxide: a predictor of morbidity in postoperative patients?
- Author
-
van Dissel, Jaap T., Groeneveld, Paul H P, Maes, Bart, Furth, Ralph van, Frolich, Marijke, and Feuth, Hans D M
- Published
- 1994
36. Cardiac-endothelium feedback
- Author
-
Westendorp, Rudi G J, vd Hoeven, Hans G, Frolich, Marijke, and Meinders, A Edo
- Published
- 1993
37. Weight changes in critically ill patients evaluated by fluid balances and impedance measurements
- Author
-
ROOS, ARNOUT N., WESTENDORP, RUDI G. J., FROLICH, MARIJKE, and MEINDERS, AREND E.
- Published
- 1993
38. Survival in selected patients with gram-negative sepsis after adjunctive therapy with HA-1A
- Author
-
van Dissel, Jaap T., van Furth, Ralph, Compier, Betty A., Feuth, Hans, and Frolich, Marijke.
- Published
- 1993
39. Preexisting cardiopulmonary disease attenuating the atrial natriuretic peptide response: results in patients with acute respiratory failure
- Author
-
Westendorp, Rudi G.J., Roos, Arnout N., Walma, Sjoukjen T., Frolich, Marijke, and Meinders, A. Edo.
- Subjects
Respiratory insufficiency -- Physiological aspects ,Lung diseases -- Physiological aspects ,Natriuretic peptides -- Physiological aspects ,Health ,Physiological aspects - Abstract
The purpose of this study was to evaluate the pathophysiologic role of atrial natriuretic peptide (ANP) as a pulmonary artery vasodilator in patients with acute respiratory failure receiving artificial ventilation. Twenty-one consecutive patients were studied, 12 without and 9 with preexisting cardiopulmonary disease. Pulmonary artery plasma ANP levels were significantly higher than the levels obtained in the superior vena cava and radial artery. Plasma ANP levels correlated significantly with the plasma levels of its second messenger, guanosine 3',5'-cyclic monophosphate (cGMP). In the 12 patients without prior cardiopulmonary disease, plasma ANP levels correlated significantly with mean pulmonary arterial pressure (MPAP). This correlation was not found in the nine patients with preexisting cardiopulmonary disease. The cGMP/ANP ratio, indicating the biologic effect of ANP, was also higher in the patients without preexisting cardiopulmonary disease. These results are compatible with clearance and vasodilator activity of ANP in the pulmonary vascular bed, but only in patients without preexisting cardiopulmonary disease. (Chest 1992; 102:1758-63), ANP=atrial natriuretic peptide; cGMP=guanosin 3',5'-cyclic ate; MPAP = mean pulmonary arterterial pressure The lung is a major target organ for ANP Released into the right auricle as a result of [...]
- Published
- 1992
40. Influence of angiotensin converting enzyme inhibition on pump function and cardiac contractility in patients with chronic congestive heart failure
- Author
-
Baur, Leo H.B., Schipperheyn, Johan J., Baan, Jan, Laarse, Arnoud van der, Buis, Beert, Wall, Ernst E. van der, Cats, Volkert Manger, Dijk, Arjan D. van, Blokland, Jacobus A.K., Frolich, Marijke, and Bruschke, Albert V.G.
- Subjects
Enalapril -- Evaluation ,Heart muscle -- Physiological aspects ,Congestive heart failure -- Drug therapy ,ACE inhibitors -- Evaluation ,Health - Abstract
Enalapril is a drug often used to treat congestive heart failure. It helps improve heart pump functioning by reducing blood volume in the ventricles. It works at the cellular level by inhibiting the enzyme that converts the hormone angiotensin into its active form; the drug is therefore of the class of angiotensin converting enzyme, or ACE, inhibitors. Angiotensin causes blood vessels to constrict (become narrower) and enalapril thus keeps them open, an effect known as vasodilation. It is also thought that enalapril may also work by enhancing cardiac muscle function by allowing a reversal of the damage to the cardiac muscle cells. This study examined the effects of this drug on unloading and remodeling (changing structure) of the ventricle and possible improvements in myocardial function at the cellular level in patients suffering from congestive heart failure. Eleven men had enalapril added to their treatment programs for congestive heart failure. Biochemical and hemodynamic (blood flow) measurements were taken before and after the drug was included. Results showed that the drug significantly decreased the activity of angiotensin converting enzyme. Significant declines were seen in right atrial pressure, pulmonary artery pressure, pulmonary capillary pressure, and left ventricular end diastolic pressure and ejection fraction at rest increased slightly (indexes of ventricular function). Measurements of cardiac muscle contractility showed no change when the drug was used. Passive properties of the ventricle during the rest phase (diastole) showed changes after drug treatment indicating remodelling. These results indicate that enalapril works to improve pump function by reshaping the ventricle, but not by improving cardiac muscle function at the cellular level. (Consumer Summary produced by Reliance Medical Information, Inc.)
- Published
- 1991
41. In vivo relationship between insulin clearance and action in healthy subjects and IDDM patients
- Author
-
Nijs, Hubert G.T., Radder, Jasper K., Frolich, Marijke, and Krans, H. Michiel J.
- Subjects
Insulin -- Physiological aspects ,Type 1 diabetes -- Complications ,Hyperglycemia -- Physiological aspects ,Health - Abstract
Insulin-dependent diabetes mellitus (IDDM) is a metabolic disorder caused by destruction of the insulin-secreting pancreatic beta cells and consequent inability to regulate blood glucose levels. The resulting hyperglycemia (high blood sugar) has been shown to have a variety of serious consequences, and must be controlled as well as possible with injections of insulin. In normal subjects, there is a strong correlation between clearance of insulin from the blood and the physiological action of this hormone. This is thought to reflect the fact that insulin is internalized by cells (hence its disappearance from the blood), and only once inside the cell can it exert its effect. In order to investigate whether or not this sequence is maintained in IDDM patients, the relationship between plasma clearance rate of insulin and insulin-stimulated glucose disposal was measured in 15 healthy volunteers and 30 patients with IDDM. Insulin levels were maintained at several different levels; at low insulin levels, diabetic patients were unresponsive to the hormone. At high insulin levels, hormone action was normal. In normal subjects, appropriate responses were seen at all levels of plasma insulin. Additionally, in normal subjects, there was a strong correlation between plasma clearance rate of insulin and glucose disposal; no such relationship was observed in IDDM patients even when statistical corrections for the diabetic state were made. This disruption of the normal response to insulin may be the result of prolonged hyperglycemia caused by IDDM. (Consumer Summary produced by Reliance Medical Information, Inc.)
- Published
- 1990
42. Influence of obesity and body fat distribution on growth hormone kinetics in humans
- Author
-
LANGENDONK, JANNEKE G., MEINDERS, A. EDO, BURGGRAAF, JACOBUS, FROLICH, MARIJKE, ROELEN, CORNE A. M., SCHOEMAKER, RIK C., COHEN, ADAM F., and PIJL, HANNO
- Subjects
Obesity -- Physiological aspects ,Adipose tissues -- Distribution ,Somatotropin -- Physiological aspects ,Menopause -- Physiological aspects ,Biological sciences - Abstract
Langendonk, Janneke G., A. Edo Meinders, Jacobus Burggraaf, Marijke Frolich, Corne A. M. Roelen, Rik C. Schoemaker, Adam F. Cohen, and Hanno Pijl. Influence of obesity and body fat distribution on growth hormone kinetics in humans. Am. J. Physiol. 277 (Endocrinol. Metab. 40): E824-E829, 1999.--We studied the kinetics of exogenous recombinant 22-kDa human growth hormone (rhGH) in premenopausal women with upper body obesity (UBO), lower body obesity (LBO), or normal body weight. A bolus of 100 mU rhGH was administered during a continuous infusion of somatostatin to suppress endogenous GH secretion. GH kinetics were investigated with noncompartmental analysis of plasma GH curves. GH peak values in response to GH infusion and plasma half-life of GH were not significantly different between normal weight and obese subjects. In contrast, GH clearance was 33% higher in LBO women and 51% higher in UBO women compared with clearance in normal weight controls. The difference in clearance between LBO and UBO was not statistically significant. Altered GH clearance characteristics contribute to low circulating GH levels in obese humans. Body fat distribution does not appear to affect GH kinetics. somatotropin; clearance; distribution volume; fat mass; fat distribution
- Published
- 1999
43. Prevalence of Glucose Intolerance Among Malays in Brunei
- Author
-
EEKELEN, ANKE VAN, STOKVIS-BRANTSMA, HENRIETTE, FROLICH, MARIJKE, SMELT, AUGUSTINUS H.M., and STOKVIS, HYLKE
- Subjects
Diabetes -- Research ,Type 2 diabetes -- Research ,Health ,Research - Abstract
In newly industrialized countries, dramatic changes in economy and lifestyle may result in changed eating habits, reduced physical activity, and increased frequency of obesity. These changes appear to lead to [...]
- Published
- 2000
44. Polymorphisms in TLR4 and TLR2 genes, cytokine production and survival in rural Ghana
- Author
-
May, Linda, Bodegom, David van, Frolich, Marijke, Lieshout, Lisette van, Slagboom, P Eline, and Westendorp, Rudi GJ and Kuningas, Maris
- Subjects
parasitic diseases ,Plasmodium falciparum ,TLR2 ,Cytokines ,TLR4 ,Mortality ,Polymorphisms - Abstract
Toll-like receptors (TLRs) are involved in the induction of an adequate immune response on infection. We hypothesized that genetic variation in TLR4 and TLR2 genes could influence this response and lead to variability in cytokine production and survival. We tested this hypothesis in 4292 participants who were followed up for all-cause mortality for 6 years and live under adverse environmental conditions in the Upper-East region of Ghana, where malaria is endemic. In 605 participants, tumor necrosis factor-a and interleukin-10 (IL10) production, after stimulation with lipopolysaccharide and zymosan, was measured. In addition, 34 single-nucleotide polymorphisms (SNPs) in TLR4 and 12 SNPs in TLR2 were genotyped and tested for association with cytokine production, malaria infection and mortality. In this comprehensive gene-wide approach, we identified novel SNPs in the TLR4 gene that influence cytokine production. From the analyzed SNPs, rs7860896 associated the strongest with IL10 production (P¼0.0005). None of the SNPs in this study associated with malaria or overall mortality risks. In conclusion, we demonstrate that genetic variation within the TLR4 gene influences cytokine production capacity, but in an endemic area does not influence the susceptibility to malaria infection or mortality.
- Published
- 2010
45. Selection for Genetic Variation Inducing Pro-Inflammatory Responses under Adverse Environmental Conditions in a Ghanaian Population
- Author
-
Kuningas Meij Eline, Westendorp, Maris, May, Linda, Tamm, Riin, Bodegom, David van, Biggelaar, Anita H. J. van den, Meij, Johannes J., Frolich, Marijke, Ziem, Juventus B., Suchiman, Helena E. D., Metspalu, Andres, Slagboom, P. Eline, and Westendorp,Rudi G.J.
- Abstract
Background: Chronic inflammation is involved in the pathogenesis of chronic age-associated, degenerative diseases. Proinflammatory host responses that are deleterious later in life may originate from evolutionary selection for genetic variation mediating resistance to infectious diseases under adverse environmental conditions. Methodology/Principal Findings: In the Upper-East region of Ghana where infection has remained the leading cause of death, we studied the effect on survival of genetic variations at the IL10 gene locus that have been associated with chronic diseases. Here we show that an IL10 haplotype that associated with a pro-inflammatory innate immune response, characterised by low IL-10 (p = 0.028) and high TNF-a levels (p = 1.3961023), was enriched among Ghanaian elders (p = 2.4661026). Furthermore, in an environment where the source of drinking water (wells/rivers vs. boreholes) influences mortality risks (HR 1.28, 95% CI [1.09–1.50]), we observed that carriers of the pro-inflammatory haplotype have a survival advantage when drinking from wells/rivers but a disadvantage when drinking from boreholes (pinteraction = 0.013). Resequencing the IL10 gene region did not uncover any additional common variants in the pro-inflammatory haplotype to those SNPs that were initially genotyped. Conclusions/Significance: Altogether, these data lend strong arguments for the selection of pro-inflammatory host responses to overcome fatal infection and promote survival in adverse environments.
- Published
- 2009
46. Genetic Variation in Pentraxin (PTX) 3 Gene Associates with PTX3 Production and Fertility in Women
- Author
-
May, Linda, Kuningas, Maris, Bodegom, David van, Meij, Hans J., Frolich, Marijke, Slagboom, P. Eline, Mantovani, Alberto, and and Westendorp, Rudi G.J.
- Subjects
Africa ,Immunology ,Female fertility ,Polymorphisms ,PTX3 - Abstract
Pentraxin 3 (PTX3) plays an important role in innate immune responses and in female fertility, as discovered with studies in mice. However, the role of PTX3 in human fertility is unknown. Here, we report on a population-based study from a rural area of Upper East Ghana (n ¼ 4346). We studied the association between the number of children given birth by women during their lifetime and ex vivo, lipopolysaccharide (LPS)-induced PTX3 production (n ¼ 362). In addition, we studied the association of genetic variation in the PTX3 gene with PTX3 production (n ¼ 617) and with female fertility (n ¼ 1999). We found that ex vivo LPS-induced PTX3 production was associated with fertility (P ¼ 0.040). Furthermore, we identified genetic variants in the PTX3 gene that influence PTX3 production, and also fertility. The strongest associations were observed for the rs6788044 single-nucleotide polymorphism (SNP). We found that carriers of this SNP had higher PTX3 production capacity (P ¼ 0.003) and higher fertility (P ¼ 0.043). The results reported here provide the first evidence, based on protein production and analysis of polymorphisms, that the long pentraxin PTX3 plays a role in female fertility in humans.
- Published
- 2009
47. Role of vitamin B12 in anemia in old age
- Author
-
Andres, Emmanuel, Federici, Laure, den Elzen, Wendy P.J., Westendorp, Rudi G.J., Frolich, Marijke, de Ruijter, Wouter, Assendelft, Willem J.J., and Gussekloo, Jacobijn
- Subjects
Vitamin B12 deficiency -- Patient outcomes ,Anemia -- Risk factors ,Anemia -- Demographic aspects ,Aged -- Physiological aspects ,Aged -- Health aspects ,Health - Published
- 2009
48. Genetic Variation in Pentraxin (PTX) 3 Gene Associates with PTX3 Production and Fertility in Women1
- Author
-
May, Linda, primary, Kuningas, Maris, additional, Bodegom, David van, additional, Meij, Hans J., additional, Frolich, Marijke, additional, Slagboom, P. Eline, additional, Mantovani, Alberto, additional, and Westendorp, Rudi G.J., additional
- Published
- 2010
- Full Text
- View/download PDF
49. Diminished and irregular TSH secretion with delayed acrophase in patients with Cushing's syndrome
- Author
-
Roelfsema, Ferdinand, primary, Pereira, Alberto M, additional, Biermasz, Nienke R, additional, Frolich, Marijke, additional, Keenan, Daniel M, additional, Veldhuis, Johannes D, additional, and Romijn, Johannes A, additional
- Published
- 2009
- Full Text
- View/download PDF
50. Contribution of partial pancreatectomy, systemic hormone delivery, and duct obliteration to glucose regulation in canine pancreas
- Author
-
van der Burg, Michael P. M., Gooszen, Hein G., Guicherit, Onno R., Jansen, Jan B. M. J., Frolich, Marijke, van Haastert, Frans A., and Lamers, Cornelis B. H. W.
- Subjects
Transplantation of organs, tissues, etc. -- Case studies -- Models ,Pancreatectomy -- Research -- Case studies -- Models ,Diabetes -- Models -- Research -- Case studies ,Pancreas -- Case studies -- Models ,Glucose metabolism -- Research -- Case studies -- Models ,Surgery -- Case studies -- Models ,Health ,Models ,Case studies ,Research - Abstract
Contribution of Partial Pancreatectomy, Systemic Hormone Delivery, and Duct Obliteration to Glucose Regulation in Canine Pancreas The results of clinical pancreas transplantation have improved considerably in the last decade in [...]
- Published
- 1989
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