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Your search keyword '"Fritzson, Ingela"' showing total 8 results
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8 results on '"Fritzson, Ingela"'

1. Hydroxyazole scaffold-based Plasmodium falciparum dihydroorotate dehydrogenase inhibitors: Synthesis, biological evaluation and X-ray structural studies

Author

Pippione, Agnese C., Sainas, Stefano, Goyal, Parveen, Fritzson, Ingela, Cassiano, Gustavo C., Giraudo, Alessandro, Giorgis, Marta, Tavella, Tatyana A., Bagnati, Renzo, Rolando, Barbara, Caing-Carlsson, Rhawnie, Costa, Fabio T.M., Andrade, Carolina Horta, Al-Karadaghi, Salam, Boschi, Donatella, Friemann, Rosmarie, and Lolli, Marco L.

Published
2019
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3. The structures of human dihydroorotate dehydrogenase with and without inhibitor reveal conformational flexibility in the inhibitor and substrate binding sites

Author

Walse, Bjorn, Dufe, Veronica Tamu, Svensson, Bo, Fritzson, Ingela, Dahlberg, Leif, Khairoullina, Alfia, Wellnar, Ulf, and Al-Karadaghi, Salam

Subjects
Plasmodium -- Genetic aspects, Enzyme inhibitors -- Chemical properties, Oxidoreductases -- Chemical properties, Biological sciences, Chemistry
Abstract

The structures of N-terminally truncated (residues Met30-Arg396) dihydroorotate dehydrogenase (DHODH) in complex with two inhibitors as well as the first structure of the enzyme to be characterized without any bound inhibitor are described. The studies have provided new insights into the dynamic features of the DHODH reaction and have provided new approaches to the design of inhibitors against DHODH.

Published
2008

7. Synthesis and Biological Evaluation of New 1,2-Dihydro-4-hydroxy-2-oxo-3-quinolinecarboxamides for Treatment of Autoimmune Disorders: Structure−Activity Relationship

Author

Jönsson, Stig, primary, Andersson, Gunnar, additional, Fex, Tomas, additional, Fristedt, Tomas, additional, Hedlund, Gunnar, additional, Jansson, Karl, additional, Abramo, Lisbeth, additional, Fritzson, Ingela, additional, Pekarski, Olga, additional, Runström, Anna, additional, Sandin, Helena, additional, Thuvesson, Ingela, additional, and Björk, Anders, additional

Published
2004
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8. Synthesis and biological evaluation of new 1,2-dihydro-4-hydroxy-2-oxo-3-quinolinecarboxamides for treatment of autoimmune disorders: structure-activity relationship.

Author

Jönsson S, Andersson G, Fex T, Fristedt T, Hedlund G, Jansson K, Abramo L, Fritzson I, Pekarski O, Runström A, Sandin H, Thuvesson I, and Björk A

Subjects
Adjuvants, Immunologic chemistry, Adjuvants, Immunologic pharmacology, Animals, Dogs, Encephalomyelitis, Autoimmune, Experimental drug therapy, Female, Hydroxyquinolines therapeutic use, Mice, Mice, Inbred C57BL, Quinolones chemistry, Quinolones therapeutic use, Structure-Activity Relationship, Adjuvants, Immunologic chemical synthesis, Autoimmune Diseases drug therapy, Quinolones chemical synthesis
Abstract

Roquinimex-related 3-quinolinecarboxamide derivatives were prepared and evaluated for treatment of autoimmune disorders. The compounds were tested in mice for their inhibitory effects on disease development in the acute experimental autoimmune encephalomyelitis model and selected compounds in the beagle dog for induction of proinflammatory reaction. Structure-activity relationships are discussed. Compound 8c, laquinimod, showed improved potency and superior toxicological profile compared to the lead compound roquinimex (1b, Linomide) and was selected for clinical studies (currently in phase II).

Published
2004
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