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2. Clinical Spectrum of Gross Hematuria Following SARS-CoV-2 Vaccination With mRNA Vaccines

Author

Ritter, Alexander; https://orcid.org/0000-0002-9049-0765, Helmchen, Birgit, Gaspert, Ariana, Bleisch, Jörg, Fritschi, Barbara, Buchkremer, Florian; https://orcid.org/0000-0003-4437-6862, Damm, Stephanie, Schmid, Nicolas, Schachtner, Thomas; https://orcid.org/0000-0001-5549-4798, Seeger, Harald; https://orcid.org/0000-0003-1552-7983, Ritter, Alexander; https://orcid.org/0000-0002-9049-0765, Helmchen, Birgit, Gaspert, Ariana, Bleisch, Jörg, Fritschi, Barbara, Buchkremer, Florian; https://orcid.org/0000-0003-4437-6862, Damm, Stephanie, Schmid, Nicolas, Schachtner, Thomas; https://orcid.org/0000-0001-5549-4798, and Seeger, Harald; https://orcid.org/0000-0003-1552-7983

Abstract

Background: Novel mRNA-based vaccines play an important role in current vaccination campaigns against SARS-CoV-2. They are highly efficacious and generally well tolerated. Vaccination in patients with immune-mediated kidney diseases is recommended. A number of cases with de novo or relapsing glomerulonephritis shortly after vaccine application were reported, some of which presented with gross hematuria. Methods: We collected 10 cases of macrohematuria following mRNA-based SARS-CoV-2 vaccination at our tertiary care institution and referring centers. Additionally we pooled all 25 published cases from the literature with ours to analyse their clinical characteristics. Results: Most macrohematuria episodes (72.2%) began within 2 days after vaccination, the majority after the second dose. In some individuals, repeated episodes occured after subsequent doses of the same vaccine. 65.7% of patients never had macrohematuria before. 45.7% were known to suffer from IgAN, the rest had no prior renal diagnosis. IgAN was the most frequent new diagnosis but ANCA-associated vasculitis and anti-GBM disease were also identified. AKI occurred in 28.6% of patients, a rise in serum creatinine not meeting KDIGO AKI criteria in 28.6%. Treatment ranged from conservative management, RAAS-inhibitors, steroids and cyclophosphamide to plasmapheresis. While renal outcomes were mainly favourable in isolated IgAN, they were poor in patients with additional or isolated small vessel vasculitis. Conclusion: Awareness of gross hematuria after SARS-CoV-2 vaccination is important. Close follow-up and additional work-up in particular in individuals without known underlying kidney disease or worsening renal function is essential. For patients with vaccine associated macrohematuria an alternative vaccine class might be considered for subsequent vaccinations.

Published
2022

6. Gesamtdiskussion, Wissen als kulturspezifischer Begriff: Asien und Europa

Author

Altenburger, Roland, Ateş, Şevket, Fritschi, Barbara, Schüpbach, Michael, University of Zurich, Rüegger, Hans-Ulrich, Arioli, Martina, and Murer, Heini

Subjects
10887 Basic Subjects, 950 History of Asia, 340 Law, 180 Ancient, medieval & eastern philosophy, U2 Asia and Europe
Published
2009

9. Hermeneutik und Recht in der Tradition des Islam

Author

Senn, Marcel, Fritschi, Barbara, Senn, M ( Marcel ), Fritschi, B ( Barbara ), Büchler, Andrea, Senn, Marcel, Fritschi, Barbara, Senn, M ( Marcel ), Fritschi, B ( Barbara ), and Büchler, Andrea

Published
2009

10. Diskussion, 2. Teil, Wissen als kulturspezifischer Begriff: Asien und Europa

Author

Rüegger, Hans-Ulrich, Arioli, Martina, Murer, Heini, Rüegger, H ( Hans-Ulrich ), Arioli, M ( Martina ), Murer, H ( Heini ), Ateş, Şevket, Fritschi, Barbara, Rüegger, Hans-Ulrich, Arioli, Martina, Murer, Heini, Rüegger, H ( Hans-Ulrich ), Arioli, M ( Martina ), Murer, H ( Heini ), Ateş, Şevket, and Fritschi, Barbara

Published
2009

11. Gesamtdiskussion, Wissen als kulturspezifischer Begriff: Asien und Europa

Author

Rüegger, Hans-Ulrich, Arioli, Martina, Murer, Heini, Rüegger, H ( Hans-Ulrich ), Arioli, M ( Martina ), Murer, H ( Heini ), Altenburger, Roland, Ateş, Şevket, Fritschi, Barbara, Schüpbach, Michael, Rüegger, Hans-Ulrich, Arioli, Martina, Murer, Heini, Rüegger, H ( Hans-Ulrich ), Arioli, M ( Martina ), Murer, H ( Heini ), Altenburger, Roland, Ateş, Şevket, Fritschi, Barbara, and Schüpbach, Michael

Published
2009

12. Wissen als kulturspezifischer Begriff: Asien und Europa. Diskussion

Author

Rüegger, Hans-Ulrich, Arioli, Martina, Murer, Heini, Rüegger, H ( Hans-Ulrich ), Arioli, M ( Martina ), Murer, H ( Heini ), Şevket, Ates, Fritschi, Barbara, Rüegger, Hans-Ulrich, Arioli, Martina, Murer, Heini, Rüegger, H ( Hans-Ulrich ), Arioli, M ( Martina ), Murer, H ( Heini ), Şevket, Ates, and Fritschi, Barbara

Published
2009

16. Iatrogenic nephrocalcinosis with acute renal failure: an underestimated complication after parathyroidectomy?

Author

Fritschi, Barbara C., Trachsler, Johannes, Varga, Zsuzsanna, Binet, Isabelle, and Fehr, Thomas

Subjects
*HYPOCALCEMIA, *PARATHYROIDECTOMY, *HYPOPARATHYROIDISM, *VITAMIN D, *CALCIUM
Abstract

Hypocalcaemia often occurs in patients after parathyroidectomy (PTX) due to hypoparathyroidism and/or hungry bone syndrome. To avoid hypocalcaemia, patients are substituted with large doses of calcium and vitamin D. Here, we present four patients, who developed acute renal failure with hypercalcaemia and/or histologically confirmed nephrocalcinosis after PTX due to oversubstitution with vitamin D analogues and calcium. As a consequence, serum and urinary calcium should be closely monitored after PTX, and calcium and vitamin D substitution should be continuously adapted to avoid not only hypocalcaemia but also nephrocalcinosis and hypercalcaemic renal failure. [ABSTRACT FROM PUBLISHER]

Published
2010
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18. Hermeneutik und Recht in der Tradition des Islam

Author

Büchler, Andrea, University of Zurich, Senn, Marcel, Fritschi, Barbara, and Büchler, Andrea

Subjects
10887 Basic Subjects, 950 History of Asia, 10888 Civil Law, 340 Law, 180 Ancient, medieval & eastern philosophy, U2 Asia and Europe
Published
2009

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