Search

Your search keyword '"Friesen, Matthew M."' showing total 4 results
Start Over Author "Friesen, Matthew M."
4 results on '"Friesen, Matthew M."'

1. Suspect screening of maternal serum to identify new environmental chemical biomonitoring targets using liquid chromatography-quadrupole time-of-flight mass spectrometry.

Author

Gerona, Roy R, Schwartz, Jackie M, Pan, Janet, Friesen, Matthew M, Lin, Thomas, and Woodruff, Tracey J

Subjects
Serum, Humans, Acids, Organic Chemicals, Benzophenones, Phenols, Sulfones, Chromatography, Liquid, Reproducibility of Results, Environmental Exposure, Environmental Monitoring, Pregnancy, Pregnancy Trimester, Second, Databases, Factual, Female, Mass Spectrometry, Tandem Mass Spectrometry, Chromatography, Reverse-Phase, endocrine disruptors, environmental organic acids, exposome, liquid chromatography-quadrupole time-of-flight mass spectrometry, non-targeted analysis, suspect screening, Chromatography, Liquid, Pregnancy Trimester, Second, Databases, Factual, Reverse-Phase, non-targeted analysis, suspect screening, Epidemiology, Chemical Sciences, Environmental Sciences, Medical and Health Sciences
Abstract

The use and advantages of high-resolution mass spectrometry (MS) as a discovery tool for environmental chemical monitoring has been demonstrated for environmental samples but not for biological samples. We developed a method using liquid chromatography-quadrupole time-of-flight MS (LC-QTOF/MS) for discovery of previously unmeasured environmental chemicals in human serum. Using non-targeted data acquisition (full scan MS analysis) we were able to screen for environmental organic acids (EOAs) in 20 serum samples from second trimester pregnant women. We define EOAs as environmental organic compounds with at least one dissociable proton which are utilized in commerce. EOAs include environmental phenols, phthalate metabolites, perfluorinated compounds, phenolic metabolites of polybrominated diphenyl ethers and polychlorinated biphenyls, and acidic pesticides and/or predicted acidic pesticide metabolites. Our validated method used solid phase extraction, reversed-phase chromatography in a C18 column with gradient elution, electrospray ionization in negative polarity and automated tandem MS (MS/MS) data acquisition to maximize true positive rates. We identified "suspect EOAs" using Agilent MassHunter Qualitative Analysis software, to match chemical formulas generated from each sample run with molecular formulas in our unique database of 693 EOAs assembled from multiple environmental literature sources. We found potential matches for 282 (41%) of the EOAs in our database. Sixty-five of these suspect EOAs were detected in at least 75% of the samples; only 19 of these compounds are currently biomonitored in National Health and Nutrition Examination Survey. We confirmed two of three suspect EOAs by LC-QTOF/MS using a targeted method developed through LC-MS/MS, reporting the first confirmation of benzophenone-1 and bisphenol S in pregnant women's sera. Our suspect screening workflow provides an approach to comprehensively scan environmental chemical exposures in humans. This can provide a better source of exposure information to help improve exposure and risk evaluation of industrial chemicals.

Published
2018

3. From knife to nebulous : physician leadership in the procedures suite

Author

Nasmyth, Guy, Palmer, Becky, Rowland, Paula, Harris, Brigitte, Friesen, Matthew M., Nasmyth, Guy, Palmer, Becky, Rowland, Paula, Harris, Brigitte, and Friesen, Matthew M.

Abstract

At BC Children's Hospital, physician leaders face complex environments replete with ambiguity. In anticipation of the new Acute Care Centre (ACC), a "procedures suite" clinical model will bring Surgery, Anaesthesiology, and Interventional Radiology programs under a shared leadership structure. The practice of leadership in this environment is juxtaposed with the distinctive skills required of these highly specialized physicians. This research explored how leadership capacity could be enhanced for this group. Sub-questions explored participants' attitudes, perceptions, and beliefs regarding the practice of leadership, and factors that were seen as contributing to successful leadership. The findings provide recommendations for enhancing physicians' leadership capacity. A mixed-method, action research methodology, consisting of participant observations, interviews, and an online survey were used. Five recommendations resulted: improve relationships among operational leaders and physician leaders, define physician leadership, expand current leadership development programs, develop quantifiable outcome measures, and build physician leadership awareness through UBC's Faculty of Medicine.

4. From knife to nebulous : physician leadership in the procedures suite

Author

Nasmyth, Guy, Palmer, Becky, Rowland, Paula, Harris, Brigitte, Friesen, Matthew M., Nasmyth, Guy, Palmer, Becky, Rowland, Paula, Harris, Brigitte, and Friesen, Matthew M.

Abstract

At BC Children's Hospital, physician leaders face complex environments replete with ambiguity. In anticipation of the new Acute Care Centre (ACC), a "procedures suite" clinical model will bring Surgery, Anaesthesiology, and Interventional Radiology programs under a shared leadership structure. The practice of leadership in this environment is juxtaposed with the distinctive skills required of these highly specialized physicians. This research explored how leadership capacity could be enhanced for this group. Sub-questions explored participants' attitudes, perceptions, and beliefs regarding the practice of leadership, and factors that were seen as contributing to successful leadership. The findings provide recommendations for enhancing physicians' leadership capacity. A mixed-method, action research methodology, consisting of participant observations, interviews, and an online survey were used. Five recommendations resulted: improve relationships among operational leaders and physician leaders, define physician leadership, expand current leadership development programs, develop quantifiable outcome measures, and build physician leadership awareness through UBC's Faculty of Medicine.

Catalog

Books, media, physical & digital resources
See catalog results