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4. Geospatial Distribution and Predictors of Mortality in Hospitalized Patients With COVID-19: A Cohort Study

Author

Mallipattu, S K, Jawa, R, Moffit, R, Hajagos, J, Fries, B, Nachman, S, Gan, T J, Saltz, M, Saltz, J, Kaushansky, K, Skopicki, H, Abell-Hart, K, Chaudhri, I, Deng, J, Garcia, V, Gayen, S, Kurc, T, Bolotova, O, Yoo, J, Dhaliwal, S, Nataraj, N, Sun, S, Tsai, C, Wang, Y, Abbasi, S, Abdullah, R, Ahmad, S, Bai, K, Bennett-Guerrero, E, Chua, A, Gomes, C, Griffel, M, Kalogeropoulos, A, Kiamanesh, D, Kim, N, Koraishy, F, Lingham, V, Mansour, M, Marcos, L, Miller, J, Poovathor, S, Rubano, J, Rutigliano, D, Sands, M, Santora, C, Schwartz, J, Shroyer, K, Spitzer, S, Stopeck, A, Talamini, M, Tharakan, M, Vosswinkel, J, and Wertheim, W

Subjects
medicine.medical_specialty, medicine.medical_treatment, Logistic regression, 01 natural sciences, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Diabetes mellitus, Major Article, medicine, 030212 general & internal medicine, 0101 mathematics, Mechanical ventilation, SARS-CoV-2, business.industry, 010102 general mathematics, Acute kidney injury, COVID-19, Acute Kidney Injury, medicine.disease, Obesity, Ventilation, AcademicSubjects/MED00290, Infectious Diseases, Oncology, Cohort, business, Hyponatremia, Geospatial Distribution, Cohort study
Abstract

BackgroundThe global coronavirus disease 2019 (COVID-19) pandemic offers the opportunity to assess how hospitals manage the care of hospitalized patients with varying demographics and clinical presentations. The goal of this study was to demonstrate the impact of densely populated residential areas on hospitalization and to identify predictors of length of stay and mortality in hospitalized patients with COVID-19 in one of the hardest hit counties internationally.MethodsThis was a single-center cohort study of 1325 sequentially hospitalized patients with COVID-19 in New York between March 2, 2020, to May 11, 2020. Geospatial distribution of study patients’ residences relative to population density in the region were mapped, and data analysis included hospital length of stay, need and duration of invasive mechanical ventilation (IMV), and mortality. Logistic regression models were constructed to predict discharge dispositions in the remaining active study patients.ResultsThe median age of the study cohort (interquartile range [IQR]) was 62 (49–75) years, and more than half were male (57%) with history of hypertension (60%), obesity (41%), and diabetes (42%). Geographic residence of the study patients was disproportionately associated with areas of higher population density (rs = 0.235; P = .004), with noted “hot spots” in the region. Study patients were predominantly hypertensive (MAP > 90 mmHg; 670, 51%) on presentation with lymphopenia (590, 55%), hyponatremia (411, 31%), and kidney dysfunction (estimated glomerular filtration rate < 60 mL/min/1.73 m2; 381, 29%). Of the patients with a disposition (1188/1325), 15% (182/1188) required IMV and 21% (250/1188) developed acute kidney injury. In patients on IMV, the median (IQR) hospital length of stay in survivors (22 [16.5–29.5] days) was significantly longer than that of nonsurvivors (15 [10–23.75] days), but this was not due to prolonged time on the ventilator. The overall mortality in all hospitalized patients was 15%, and in patients receiving IMV it was 48%, which is predicted to minimally rise from 48% to 49% based on logistic regression models constructed to project disposition in the remaining patients on ventilators. Acute kidney injury during hospitalization (odds ratioE, 3.23) was the strongest predictor of mortality in patients requiring IMV.ConclusionsThis is the first study to collectively utilize the demographics, clinical characteristics, and hospital course of COVID-19 patients to identify predictors of poor outcomes that can be used for resource allocation in future waves of the pandemic.

Published
2020
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14. Understanding of uranium extraction mechanisms from phosphoric and sulphuric media using DEHCNPB

Author

Fries, B., Berger, C., Marie, C., Pacary, V., Sorel, C., Mokhtari, H., Charbonnel, M.-C., CEA-Direction des Energies (ex-Direction de l'Energie Nucléaire) (CEA-DES (ex-DEN)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), SEPA, AREVA NC, amplexor, amplexor, ORANO, and CADARACHE, Bibliothèque

Subjects
inorganic chemicals, [PHYS.NUCL] Physics [physics]/Nuclear Theory [nucl-th], Uranium extraction, [PHYS.NUCL]Physics [physics]/Nuclear Theory [nucl-th], [PHYS.NEXP] Physics [physics]/Nuclear Experiment [nucl-ex], technology, industry, and agriculture, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], complex mixtures, solvent extraction, uranium, phosphoric and sulfuric media, iron, DEHCNPB, process modeling, ComputingMilieux_MISCELLANEOUS
Abstract

International audience; Phosphate rocks are widely exploited for the manufacturing of phosphoric acid and fertilizers but they contain uranium (30-300 ppm). Therefore, recovering this uranium would enable the decontamination of phosphoric acid while valorizing uranium for the nuclear industry. Following a renewal of interest for the recovery of uranium from phosphate ores in the past few years, new extractant molecules were investigated in order to develop a new solvent extraction process. An amidophosphonate, the butyl-1-[N,N-bis-2-ethylhexyl)carbamoyl]nonyl phosphonic acid (DEHCNPB), showed good uranium extraction efficiency while meeting U/Fe decontamination requirements (as demonstrated during pilot scale trials). Afterwards, DEHCNPB was also used for the extraction of uranium from conventional resources (from sulfuric lixiviation media). However, pilot scale trials showed poorer performances, as uranium leaks in raffinates were higher than expected. The objective here is to study uranium and iron extraction mechanisms from those two different media (phosphoric and sulfuric). Thermodynamical data were acquired such as extraction isotherms, slope analysis, phosphates/ sulfates and water extraction. These data showed different behaviors depending on the initial medium. Spectroscopic techniques such as FTIR, NMR, ESI-MS and EXAFS were also investigated to study uranium-DEHCNPB complexes formed in the organic phase, enabling the determination of stoichiometries and coordination modes

Published
2017

20. Understanding of iron extraction mechanisms from phosphate and sulfuric media using DEHCNPB

Author

Fries, B., Marie, C., Pacary, V., Mokhtari, H., Charbonnel, Mc., CEA-Direction des Energies (ex-Direction de l'Energie Nucléaire) (CEA-DES (ex-DEN)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), AREVA MINES [Courbevoie], and amplexor, amplexor

Subjects
[PHYS.NUCL] Physics [physics]/Nuclear Theory [nucl-th], [PHYS.NUCL]Physics [physics]/Nuclear Theory [nucl-th], [PHYS.NEXP] Physics [physics]/Nuclear Experiment [nucl-ex], [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2016

21. Das chemotaktische Verhalten von Alveolarmakrophagen und Blutmonozyten nach Expositionen mit unterschiedlichen NO2-Konzentrationen

Author

J. Müller-Quernheim, Gross S, Marli Maria Knorst, Fries B, Neuwirth R, Ferlinz R, and Kienast K

Subjects
Lung, Chemistry, Healthy subjects, Chemotaxis, General Medicine, respiratory system, Diagnostic Bronchoscopy, Andrology, medicine.anatomical_structure, Bronchial carcinoma, Air exposure, medicine, Cytotoxic T cell, Cytotoxicity
Abstract

The chemotaxis of alveolar macrophages (AM) and blood monocytes (BM) is important in the elimination of particles and microorganisms which have invaded the lung. The effect of nitrogen dioxide (NO2) on chemotaxis was tested on AM obtained by diagnostic bronchoscopy from five patients suspected of having bronchial carcinoma (four men, one woman; mean age 59 +/- 10 years). Blood monocytes were also studied with blood from seven healthy subjects (five men, two women; mean age 32 +/- 10 years). These cells were placed on polycarbonate membranes for 15 min each, exposed to NO2 concentrations between 1.0 and 5.0 parts per million (ppm), and then incubated with complement component C5a as chemotactically active agent. The number of AM or BM which actively migrated through the polycarbonate membrane under the influence of C5a was measured by means of a light microscope. The migration rate of AM (compared to air exposure) was reduced by 33% with 1.0 ppm NO2 and by 61% with 5.0 ppm. The migration rate of BM in similar conditions was reduced by as much as 55%. There was no significant cytotoxic effect of NO2 exposure at 1.0 and 3.0 ppm. With 5.0 ppm 13.0 +/- 3.0 cells were no longer viable. These results indicate that NO2 concentrations relevant to indoor conditions affect the chemotaxis of AM and BM after short-time NO2 exposures. The data further suggest that NO2 exposures of these cells depressed chemotactic mechanisms without relevant cytotoxicity.

Published
2008
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22. Understanding of uranium extraction mechanisms from phosphate and sulfuric media using dehcnpb

Author

Fries, B., Marie, C., Pacary, V., Mokhtari, H., Charbonnel, Mc., amplexor, amplexor, CEA-Direction des Energies (ex-Direction de l'Energie Nucléaire) (CEA-DES (ex-DEN)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), and AREVA (FRANCE)

Subjects
[PHYS.NUCL] Physics [physics]/Nuclear Theory [nucl-th], Understanding, mechanisms, [PHYS.NUCL]Physics [physics]/Nuclear Theory [nucl-th], [PHYS.NEXP] Physics [physics]/Nuclear Experiment [nucl-ex], media, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], sulfuric, uranium, from, DEHCNPB, extraction, ComputingMilieux_MISCELLANEOUS, phosphate
Abstract

International audience

Published
2016

27. Poster Session 4The imaging examination and quality assessmentP957Economic impact analysis and quality performance of working with cardiovascular sonographers in high-volume echocardiography laboratoryP958Feasibility of temporal super resolution enhancement of echocardiographic images to diagnose cardiac DiseasesP959Remote medical diagnostician project - Achievements and limitation in tele-echocardiographyP960Right atrial remodeling and galectin-3 are associated with functional capacity in patients with pulmonary arterial hypertensionP961Interatrial electromechanical delay assessed by tissue doppler imaging can separate adults with prehypertension from healthy normotensive controlsP962Preliminary results of an extensive echocardiographic pacemaker optimization protocol for cardiac resynchronization therapyP963Left ventricular global and regional myocardial function in patients with double orifice mitral valve after radical correction on atrioventricular septal defectP964Improving quantitation of left ventricular ejection fraction in a tertiary echocardiography lab - marrying (or merging) guidelines and new technologyP965Echocardiographic evaluation of cardiac function and hemodynamics during LVAD-based resuscitation from cardiac arrest - a porcine studyP966Systolic excursion of the right ventricular outflow tract as a marker of right ventricular dysfunctionP967The impact of the new 2016 ASE/EACVI recommendations in the prevalence and grades of diastolic dysfunction: an analysis from the general populationP968Differential microRNA-21 and microRNA-133 gene expression levels in peripheral blood mononuclear cells from patients with heart failure with preserved ejection fractionP969CMR evaluation of cardiac thrombi and masses by T1 and T2 mapping : an observational studyP970Effect of coronary artery ectasia on left ventricular deformation mechanics. A 2D Speckle Tracking Echocardiography studyP971Diagnostic performance of stress Echo, SPECT, PET, stress CMR, CTCA, CTP and FFRCT for the assessment of CAD versus invasive FFR: a metaanalysisP972Utility of early assessment of myocardial mechanics in STEMI patients treated by primary percutaneous coronary intervention to predict major adverse cardiac events during the first 12 months of folloP973Role of left atrial reservoir in the prediction of increased left ventricular filling pressures in patients with ST-segment elevation myocardial infarctionP974Does the left ventricle ejection fraction improves the Grace risk score accuracy? P975Can we predict significant coronary stenosis using regional strain analysis in non-ST elevation acute coronary syndrome?P976Persistence of pulmonary hypertension after transcatheter aortic valve replacement: incidence and prognostic impactP977Global longitudinal strain is an independent predictor of all cause mortality in patients with severe aortic valve stenosis undergoing valve replacement or treated conservativallyP978Contribution of left ventricular diastolic dysfunction and myocardial fibrosis to pulmonary hypertension in severe aortic stenosisP979Left atrial dysfunction as a determinant of pulmonary hypertension in patients with isolated severe aortic stenosis and preserved left ventricular ejection fractionP980Intraprocedural monitoring protocol using routine transthoracic echocardiography with backup transesophageal probe in transcatheter aortic valve replacement: a single center experience

Author

De Chiara, B., primary, Ranjbar, S., primary, Szczesniak-Stanczyk, D., primary, Gabrielli, L., primary, Djikic, D., primary, Barbier, P., primary, Hristova, K., primary, Erne, D., primary, Zayat, R., primary, Crowe, TM., primary, Almeida, J., primary, Marketou, M., primary, Caspar, T., primary, Kouris, N., primary, Pontone, G., primary, Trifunovic, D., primary, Cusma Piccione, M., primary, Madeira, M., primary, Lovric, D., primary, Drakopoulou, M., primary, Fries, B., primary, Krivickiene, A., primary, Mateescu, AD., primary, Stella, S., primary, Casadei, F., additional, Peritore, A., additional, Spano, F., additional, Santambrogio, G., additional, Vicario, M., additional, Trolese, I., additional, Gallina, C., additional, Giannattasio, C., additional, Moreo, A., additional, Karvandi, M., additional, Badano, LP., additional, Brzozowski, W., additional, Blaszczyk, R., additional, Szyszko, M., additional, Zarczuk, R., additional, Janowski, M., additional, Wysokinski, A., additional, Stanczyk, B., additional, Sitges, M., additional, Castro, P., additional, Verdejo, H., additional, Ocaranza, MP., additional, Sepulveda, P., additional, Llevaneras, S., additional, Baraona, F., additional, Salinas, M., additional, Lavanderos, S., additional, Mujovic, N., additional, Dejanovic, B., additional, Peric, V., additional, Marinkovic, M., additional, Jankovic, N., additional, Orbovic, B., additional, Simic, D., additional, Guglielmo, M., additional, Salvini, L., additional, Savioli, G., additional, Dasheva, A., additional, Marinov, R., additional, Lasarov, S., additional, Mitev, I., additional, M, P., additional, Rhodes, K., additional, Bartlett, M., additional, Chong, A., additional, Wahi, S., additional, Derwall, M., additional, Ebeling, A., additional, Nix, C., additional, Marx, G., additional, Autschbach, R., additional, Hatam, N., additional, Sonecki, P., additional, Brewis, MJ., additional, Church, AC., additional, Johnson, MK., additional, Peacock, AJ., additional, Fontes-Carvalho, R., additional, Sampaio, F., additional, Ribeiro, J., additional, Bettencourt, P., additional, Leite-Moreira, A., additional, Azevedo, A., additional, Kontaraki, J., additional, Parthenakis, P., additional, Maragkoudakis, S., additional, Touloupaki, M., additional, Patrianakos, A., additional, Konstantinou, J., additional, Vernardos, M., additional, Logakis, J., additional, Vardas, P., additional, El Ghannudi, S., additional, Ohlmann, P., additional, Lawson, A., additional, Morel, O., additional, Ohana, M., additional, Roy, C., additional, Gangi, A., additional, Germain, P., additional, Kostakou, P., additional, Dagre, A., additional, Trifou, E., additional, Rodis, I., additional, Kostopoulos, V., additional, Olympios, CD., additional, Guaricci, AI., additional, Verdecchia, M., additional, Andreini, D., additional, Baggiano, A., additional, Beltrama, V., additional, Ferro, G., additional, Carita', P., additional, Pepi, M., additional, Krljanac, G., additional, Savic, L., additional, Asanin, M., additional, Matovic, D., additional, Stepanovic, J., additional, Stankovic, G., additional, Mrdovic, I., additional, Terrizzi, A., additional, Trio, O., additional, Oteri, A., additional, D'amico, G., additional, Ioppolo, A., additional, Nucifora, G., additional, Zucco, M., additional, Sergi, M., additional, Nicotera, A., additional, Boretti, I., additional, Carerj, S., additional, Zito, C., additional, Teixeira, R., additional, Reis, L., additional, Dinis, P., additional, Fernandes, A., additional, Caetano, F., additional, Almeida, I., additional, Costa, M., additional, Goncalves, L., additional, Reskovic Luksic, V., additional, Baricevic, Z., additional, Dosen, D., additional, Pasalic, M., additional, Ostojic, Z., additional, Brestovac, M., additional, Bulum, J., additional, Separovic Hanzevacki, J., additional, Toutouzas, K., additional, Stathogiannis, K., additional, Michelongona, A., additional, Latsios, G., additional, Synetos, A., additional, Trantalis, G., additional, Kaitozis, O., additional, Brili, S., additional, Tousoulis, D., additional, Liu, D., additional, Hu, K., additional, Voelker, W., additional, Ertl, G., additional, Weidemann, F., additional, Herrmann, S., additional, Gumauskiene, B., additional, Drebickaite, E., additional, Ereminiene, E., additional, Vaskelyte, JJ., additional, Calin, A., additional, Rosca, M., additional, Beladan, CC., additional, Enache, R., additional, Calin, C., additional, Cosei, I., additional, Botezatu, S., additional, Simion, M., additional, Ginghina, C., additional, Popescu, BA., additional, Rosa, I., additional, Marini, C., additional, Ancona, F., additional, Latib, A., additional, Monitorano, M., additional, Colombo, A., additional, Margonato, A., additional, and Agricola, E., additional

Published
2016
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28. Development of a new solvent extraction process based on butyl-1-[N,N-bis(2-ethylhexyl)carbamoyl]nonyl phosphonic acid for the selective recovery of uranium(VI) from phosphoric acid

Author

Miguirditchian, M., primary, Bernier, G., additional, Pacary, V., additional, Balaguer, C., additional, Sorel, C., additional, Berlemont, R., additional, Fries, B., additional, Bertrand, M., additional, Camès, B., additional, Leydier, A., additional, Turgis, R., additional, Arrachart, G., additional, Pellet-Rostaing, S., additional, and Mokhtari, H., additional

Published
2016
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31. A unified model for nursing home quality: the four corner approach

Author

Murphy, K., Morris, J., Fries, B., Nonemaker, S., and James, M.

Subjects
Health, Seniors
Abstract

This paper describes a model for nursing home (NH) quality using a limited set of dimensions. In model development we used the quality indicator (QI) definitions from CMS's 'Mega QI' project. Four dimensions ('corners') were selected (with defining QIs): function (mobility, ADLs), psycho-social (cognition, engagement, depression), clinical (pain, pressure ulcers, delirium), and nutrition (weight loss). Using a large state's MDS data aggregated to the facility, 16%, 24%, 14%, and 24% of NHs performed well (placed in the upper quartile on all related QIs) in each of the 4 'corners,' respectively. Only 1% scored well on all 4, and 5% on 3; 36% scored well on none. Facilities performing well on all 4 dimensions had an average of 8.2 other QIs in the upper quartile; those with none averaged only 1.8 (p

Published
2002

32. Convergent validity and distributional properties of performance quality indicators in post-acute care settings

Author

Morris, J., Jones, R., Hirdes, J., and Fries, B.

Subjects
Health, Seniors
Abstract

The goals of the paper were to examine the validity and reliability of administrative data used to construct performance measures in post-acute care settings. This was accomplished by simultaneously collecting administrative data and supplementing this with research instruments or other tools designed for the assessment of similar constructs. The validation results were favorable, and the resulting performance measures display similar disease profiles across varied post-acute care settings. The performance indicators described in this paper provide a basis for standardized assessments within the post-acute arena, facilitating inter-program quality monitoring and improvement activities. Seven discrete measures were evaluated. Two related to functioning, one addressing overall ADL status and the second locomotion. The others five measures represented a diverse set of clinical complications, including pain, cognitive status, communication, mood, and incontinence. The need for better data in the post-acute environment is pressing, given the rapid growth in the volume of services and expenditures for such care, and the associated need to ensure that patients receive the most appropriate care possible.

Published
2002

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