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136 results on '"Friend, P.J."'

4. Global Transplantation COVID Report March 2020

Author

Ahn, C., Amer, H., Anglicheau, D., Ascher, N.L., Baan, C.C., Battsetset, G., Bat-Ireedui, B., Berney, T., Betjes, M.G.H., Bichu, S., Birn, H., Brennan, D., Bromberg, J., Caillard, S., Cannon, R.M., Cantarovich, M., Chan, A., Chen, Z.S., Chapman, J.R., Cole, E.H., Cross, N., Durand, F., Egawa, H., Emond, J.C., Farrero, M., Friend, P.J., Geissler, E.K., Ha, J., Haberal, M.A., Henderson, M.L., Hesselink, D.A., Humar, A., Jassem, W., Jeong, J.C., Kaplan, B., Kee, T., Kim, S.J., Kumar, D., Legendre, C.M., Man, K., Moulin, B., Muller, E., Munkhbat, R., Od-Erdene, L., Perrin, P., Rela, M., Tanabe, K., Tedesco Silva, H., Tinckam, K.T., Tullius, S.G., and Wong, G.

Published
2020
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22. Modelling and experimental characterization of an ionic polymer metal composite actuator

Author

Friend, P.J., Grobler, A.J., Dr, Van Schoor, G., Prof, Bessarabov, D., Dr, 12810932 - Grobler, Andries Johannes (Supervisor), 12134457 - Van Schoor, George (Supervisor), and 22730389 - Bessarabov, Dmitri Georgievich (Supervisor)

Subjects
equivalent circuit model, Ionic polymer metal composites, actuator
Abstract

MEng (Electrical and Electronic Engineering), North-West University, Potchefstroom Campus This study is about modelling an ionic polymer metal composite (IPMC) actuator and the experimental characterization thereof. In this study a brief background on IPMCs are given to the reader and then the research that has been done in various fields that are of importance to this study was discussed. From this the equipment required to develop an experimental setup was determined. The experimental setup was designed and mainly consist of a load cell, a laser displacement sensor, a data acquisition system, and a clamp for the IPMC. A grey box model was used that consist of an electrical equivalent circuit and an electromechanical model. The model was implemented in Simulink and was verified by using parameters and results from literature. The parameter estimation that was done in Simulink was also verified with those values. The model was developed for a Nafion N117 sample plated with a Platinum loading of 10 mgPt/cm2. The model could sufficiently predict the absorbed current and the blocked force. The behaviour of seven different samples were investigated. Samples varied in terms of the Platinum loading and the membrane thickness. The response of each sample was investigated for different input voltages. The influence of input voltage, input frequency, humidity and temperature was also investigated. It was seen that the amplitude of the input voltage, the relative humidity and the temperature affect the response of the IPMC greatly. The experimental data from the sample was used to validate the model. The model could sufficiently predict the blocked forces and the displacement for a step input. Masters

Published
2018

31. The impact of thiopurine S-methyltransferase polymorphisms on azathioprine dose 1 year after renal transplantation

Author

Fabre, M.A., Jones, D.C., Bunce, M., Morris, P.J., Friend, P.J., Welsh, K.I., Marshall, S.E., Fabre, M.A., Jones, D.C., Bunce, M., Morris, P.J., Friend, P.J., Welsh, K.I., and Marshall, S.E.

Abstract

Azathioprine metabolism is influenced by activity of the enzyme thiopurine S-methyltransferase (TPMT), which varies markedly between individuals. In this study we examined the influence of TPMT gene polymorphisms on azathioprine dose 1 year after renal transplantation. TPMT coding and promoter genotypes were determined using PCR-based assays. Azathioprine dose, white cell count, and intercurrent events throughout the first year after renal transplantation were ascertained from contemporaneous clinical notes. All patients analysed (n = 172) received an initial azathioprine dose of 1.5 mg/kg per day. Twelve individuals with one variant TPMT coding allele were detected (*3A n = 11, *3C n = 1). Of these, 58% required azathioprine dose reduction because of leucopenia, compared to only 30% of homozygous wild-type patients (P = 0.04). A significant correlation between the presence of ≥11 variable number tandem repeats (VNTRs) in the TPMT promoter and reduction in azathioprine dose was also identified (P = 0.001). We concluded that when azathioprine is administered at an initial dose of 1.5 mg/kg per day, both coding and promoter TPMT polymorphisms influence the dose tolerated.

Published
2004

33. Preliminary Single-Center Canadian Experience of Human Normothermic Ex VivoLiver Perfusion: Results of a Clinical Trial

Author

Bral, M., Gala-Lopez, B., Bigam, D., Kneteman, N., Malcolm, A., Livingstone, S., Andres, A., Emamaullee, J., Russell, L., Coussios, C., West, L.J., Friend, P.J., and Shapiro, A.M.J.

Abstract

After extensive experimentation, outcomes of a first clinical normothermic machine perfusion (NMP) liver trial in the United Kingdom demonstrated feasibility and clear safety, with improved liver function compared with standard static cold storage (SCS). We present a preliminary single-center North American experience using identical NMP technology. Ten donor liver grafts were procured, four (40%) from donation after circulatory death (DCD), of which nine were transplanted. One liver did not proceed because of a technical failure with portal cannulation and was discarded. Transplanted NMP grafts were matched 1:3 with transplanted SCS livers. Median NMP was 11.5 h (range 3.3–22.5 h) with one DCD liver perfused for 22.5 h. All transplanted livers functioned, and serum transaminases, bilirubin, international normalized ratio, and lactate levels corrected in NMP recipients similarly to controls. Graft survival at 30 days (primary outcome) was not statistically different between groups on an intent-to-treat basis (p = 0.25). Intensive care and hospital stays were significantly more prolonged in the NMP group. This preliminary experience demonstrates feasibility as well as potential technical risks of NMP in a North American setting and highlights a need for larger, randomized studies.

Published
2017
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41. Adult small intestinal transplantation in England and Wales

Author

Cameron, E.A.B., Jamieson, N.V., Pollard, S., Friend, P.J., Watson, C., Calne, R.Y., Davies, M., Gimson, A.E., Bradley, J.A., Shaffer, J., and Middleton, S.J.

Subjects
Colorectal diseases -- Care and treatment -- Research, Intestine, Small -- Health aspects -- Research, Gastrointestinal diseases -- Care and treatment -- Research, Health, Care and treatment, Research, Health aspects
Abstract

Background: Two transplantation centres in the UK are commissioned by the National Specialist Commissioning Advisory Group for England and Wales to assess small intestinal transplantation in adults. The joint experience [...]

Published
2004

42. Liver Transplantation After Ex VivoNormothermic Machine Preservation: A Phase 1 (First-in-Man) Clinical Trial

Author

Ravikumar, R., Jassem, W., Mergental, H., Heaton, N., Mirza, D., Perera, M.T.P.R., Quaglia, A., Holroyd, D., Vogel, T., Coussios, C.C., and Friend, P.J.

Abstract

The number of donor organs suitable for liver transplantation is restricted by cold preservation and ischemia–reperfusion injury. We present the first patients transplanted using a normothermic machine perfusion (NMP) device that transports and stores an organ in a fully functioning state at 37°C. In this Phase 1 trial, organs were retrieved using standard techniques, attached to the perfusion device at the donor hospital, and transported to the implanting center in a functioning state. NMP livers were matched 1:2 to cold-stored livers. Twenty patients underwent liver transplantation after NMP. Median NMP time was 9.3 (3.5–18.5) h versus median cold ischaemia time of 8.9 (4.2–11.4) h. Thirty-day graft survival was similar (100% NMP vs. 97.5% control, p = 1.00). Median peak aspartate aminotransferase in the first 7 days was significantly lower in the NMP group (417 IU [84–4681]) versus (902 IU [218–8786], p = 0.03). This first report of liver transplantation using NMP-preserved livers demonstrates the safety and feasibility of using this technology from retrieval to transplantation, including transportation. NMP may be valuable in increasing the number of donor livers and improving the function of transplantable organs.

Published
2016
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