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1. Zircon age spectra to quantify magma evolution

Author

Schmitt, A.K., primary, Sliwinski, J., additional, Caricchi, L., additional, Bachmann, O., additional, Riel, N., additional, Kaus, B.J.P., additional, Cisneros de Léon, A., additional, Cornet, J., additional, Friedrichs, B., additional, Lovera, O., additional, Sheldrake, T., additional, and Weber, G., additional

Published
2023
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2. Allogeneic transplantation in T‐cell lymphoma: Lessons from the AATT study

Author

Tournilhac, O., primary, Altmann, B., additional, Friedrichs, B., additional, Bouabdallah, K., additional, Cartron, G., additional, Nickelsen, M., additional, Wulf, G., additional, Leclerc, M., additional, Vilatte, A., additional, Turlure, P., additional, Sanhès, L., additional, Houot, R., additional, Roussel, M., additional, de Leval, L., additional, Rosenwald, A., additional, Gaulard, P., additional, Dreger, P., additional, Glass, B., additional, Latière, C., additional, Damaj, G., additional, Lenz, G., additional, Reimer, P., additional, Banos, A., additional, Bilger, K., additional, Durot, E., additional, Sibon, D., additional, Wagner, E., additional, Nguyen, S., additional, Trümper, L., additional, Ziepert, M., additional, and Schmitz, N., additional

Published
2023
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3. P1184: PHASE I TRIAL OF MB-CART2019.1 IN PATIENTES WITH RELAPSED OR REFRATORY B-CELL NON-HODGKIN LYMPHOMA: 2 YEAR FOLLOW-UP REPORT

Author

Borchmann, P., primary, Lohneis, A., additional, Gödel, P., additional, Balke-Want, H., additional, Schmid, C., additional, Ayuk, F., additional, Holtkamp, S., additional, Hanssens, L., additional, Zadoyan, G., additional, Friedrichs, B., additional, Assenmacher, M., additional, Bürger, I., additional, Schneider, D., additional, Overstijns, T., additional, Scheid, C., additional, Holtick, U., additional, Miltenyi, S., additional, and Hallek, M., additional

Published
2022
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4. PB2115: TRIAL IN PROGRESS: A RANDOMIZED PHASE II STUDY OF MB-CART2019.1 COMPARED TO STANDARD OF CARE THERAPY IN PATIENTS WITH RELAPSED/REFRACTORY DLBCL INELIGIBLE FOR AUTOLOGOUS STEM CELL TRANSPLANTATION

Author

Borchmann, P., primary, Vandenberghe, P., additional, Urbano, A., additional, Haioun, C., additional, Lemonnier, F., additional, Griškevicius, L., additional, Maury, S., additional, Holtkamp, S., additional, Friedrichs, B., additional, Zadoyan, G., additional, Hanssens, L., additional, Brillant, C., additional, Bethke, U., additional, Assenmacher, M., additional, Bürger, I., additional, Philippe, B., additional, Overstijns, T., additional, Jäger, U., additional, and Kersten, M. J., additional

Published
2022
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5. Multitechnique Geochronology of Intrusive and Explosive Activity on Piton des Neiges Volcano, Réunion Island

Author

Famin, V., Paquez, C., Danišík, Martin, Gardiner, Nicholas, Michon, L., Kirkland, Christopher, Berthod, C., Friedrichs, B., Schmitt, A.K., Monié, P., Famin, V., Paquez, C., Danišík, Martin, Gardiner, Nicholas, Michon, L., Kirkland, Christopher, Berthod, C., Friedrichs, B., Schmitt, A.K., and Monié, P.

Abstract

The construction of ocean island basaltic volcanoes consists of a succession of eruptions, intrusions, and metamorphism. These events are often temporally ill-constrained because the most widely used radiometric dating methods applicable to mafic volcanic rocks (K-Ar or 40Ar/39Ar on whole rock or groundmass) are prone to inaccuracy when applied to slowly cooled, altered, or vesicular and aphyric products. Here, we adopt a multitechnique geochronology approach (including zircon U-Pb, phlogopite 40Ar/39Ar, zircon and apatite (U-Th)/He, and zircon double-dating) to demonstrate its efficacy when applied to basaltic volcanoes. Taking the main volcano of Réunion Island (Piton des Neiges) as a case study, we establish the time of the major plutonic, metamorphic, and explosive events that had resisted previous dating attempts. We document four stages of pluton emplacement and metamorphism at 2,200–2,000 ka, 1,414 ± 8 ka, 665 ± 78 ka, and 150–110 ka, all coinciding with volcanism revival after quiescent intervals. We also date a major Plinian eruption at 188.2 ± 10.4 ka, coeval with the formation age of a large caldera, and, finally, we constrain the last eruption of Piton des Neiges to 27 ka, revising a previous estimate of 12 ka. By resolving several conundrums of Réunion's geological history, our multitechnique geochronology approach reveals that endogenous growth of a volcanic island proceeds as pulses at the beginning of renewed volcanism. We also demonstrate that crosschecking eruptions ages by diversified dating techniques is important to better assess the timing and recurrence of basaltic volcanic activity, with implications for hazard prediction.

Published
2022

7. The Medial Offshore Record of Explosive Volcanism Along the Central to Eastern Aegean Volcanic Arc: 1. Tephrostratigraphic Correlations

Author

Kutterolf, S., primary, Freundt, A., additional, Hansteen, T. H., additional, Dettbarn, R., additional, Hampel, F., additional, Sievers, C., additional, Wittig, C., additional, Allen, S. R., additional, Druitt, T. H., additional, McPhie, J., additional, Nomikou, P., additional, Pank, K., additional, Schindlbeck‐Belo, J. C., additional, Wang, K.‐L., additional, Lee, H.‐Y., additional, and Friedrichs, B., additional

Published
2021
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8. The Medial Offshore Record of Explosive Volcanism Along the Central to Eastern Aegean Volcanic Arc: 1. Tephrostratigraphic Correlations

Author

Kutterolf, S. Freundt, A. Hansteen, T. H. Dettbarn, R. and Hampel, F. Sievers, C. Wittig, C. Allen, S. R. Druitt, T. H. McPhie, J. Nomikou, P. Pank, K. Schindlbeck-Belo, J. C. Wang, K-L Lee, H-Y Friedrichs, B.

Abstract

The Milos, Christiana-Santorini-Kolumbo (CSK) and Kos-Yali-Nisyros (KYN) volcanic complexes of the Aegean Volcanic Arc have repeatedly produced highly explosive eruptions from at least similar to 360 ka into historic times and still show recent unrest. We present the marine tephra record from an array of 50, up to 7.4 m long, sediment cores along the arc collected in 2017 during RV Poseidon cruise POS513, which complements earlier work on distal to ultra-distal eastern Mediterranean sediment cores. A unique set of glass-shard trace element (LA-ICPMS) compositions complements our major element (EMP) data on 220 primary ash layers and 40 terrestrial samples to support geochemical fingerprinting for correlations with 19 known tephras from all three volcanic complexes and with the 39 ka Campanian Ignimbrite from the Campi Flegrei, Italy. The correlations include 11 eruptions from CSK (Kameni, Kolumbo 1650, Minoan, Cape Riva, Cape Tripiti, Upper Scoriae 1 and 2, Middle Pumice, Cape Thera, Lower Pumice, Cape Therma 3). We identify a previously unknown widespread tephra from a plinian eruption on Milos (Firiplaka Tephra). Near the KYN we correlate marine tephras with the Kos Plateau Tuff, the Yali 1 and Yali 2 tephras, and the Upper and Lower Pumice on Nisyros. Between these two major tephras, we found two tephras from Nisyros not yet observed on land. The four Nisyros tephras form a systematic trend toward more evolved magma compositions. In the companion paper we use the tephrostratigraphic framework established here to constrain new eruption ages and magnitudes as a contribution to volcanic hazard assessment.

Published
2021

9. The medial offshore record of explosive volcanism along the central to eastern Aegean Volcanic Arc, part 1: Tephrostratigraphic correlations

Author

Kutterolf, Steffen, Freundt, Armin, Hansteen, Thor H., Dettbarn, Rebecca, Hampel, Fabian, Sievers, C., Wittig, Cathrin, Allen, S., Druitt, T. H., McPhie, J., Nomikou, P., Pank, Katharina, Schindlbeck-Belo, Julie, Wang, K.‐L., Lee, H.‐Y., Friedrichs, B., Kutterolf, Steffen, Freundt, Armin, Hansteen, Thor H., Dettbarn, Rebecca, Hampel, Fabian, Sievers, C., Wittig, Cathrin, Allen, S., Druitt, T. H., McPhie, J., Nomikou, P., Pank, Katharina, Schindlbeck-Belo, Julie, Wang, K.‐L., Lee, H.‐Y., and Friedrichs, B.

Abstract

The Milos, Christiana-Santorini-Kolumbo (CSK) and Kos-Yali-Nisyros (KYN) volcanic complexes of the Aegean Volcanic Arc have repeatedly produced highly explosive eruptions from at least ∼360 ka into historic times and still show recent unrest. We present the marine tephra record from an array of 50, up to 7.4 m long, sediment cores along the arc collected in 2017 during RV Poseidon cruise POS513, which complements earlier work on distal to ultra-distal eastern Mediterranean sediment cores. A unique set of glass-shard trace element (LA-ICPMS) compositions complements our major element (EMP) data on 220 primary ash layers and 40 terrestrial samples to support geochemical fingerprinting for correlations with 19 known tephras from all three volcanic complexes and with the 39 ka Campanian Ignimbrite from the Campi Flegrei, Italy. The correlations include eleven eruptions from CSK (Kameni, Kolumbo 1650, Minoan, Cape Riva, Cape Tripiti, Upper Scoriae 1 and 2, Middle Pumice, Cape Thera, Lower Pumice, Cape Therma 3). We identify a previously unknown widespread tephra from a plinian eruption on Milos (Firiplaka Tephra). Near the KYN we correlate marine tephras with the Kos Plateau Tuff, the Yali 1 and Yali 2 tephras, and the Upper and Lower Pumice on Nisyros. Between these two major tephras, we found two tephras from Nisyros not yet observed on land. The four Nisyros tephras form a systematic trend toward more evolved magma compositions. In the companion paper we use the tephrostratigraphic framework established here to constrain new eruption ages and magnitudes as a contribution to volcanic hazard assessment.

Published
2021

20. A hybrid numerical technique to model 3-D flow fields in resin transfer molding processes

Author

Friedrichs, B. and Guceri, S.I.

Subjects
Numerical analysis -- Models, Flow visualization -- Models, Gums and resins -- Production processes -- Models, Molding (Chemical technology) -- Models -- Production processes, Engineering and manufacturing industries, Science and technology, Production processes, Models
Abstract

A hybrid two- /three-dimensional solution technique is presented to model 3-D flow fields in resin transfer moeling using Darcy's law. The 3-D flow field is only solved for regions where all three velocity components are significant, thus largely reducing the number of unknowns. Elsewhere, the commonly used 2-D approximation for flow in thin gaps between plates is employed. The method is applied to regions where the flow splits, such as T-joints. Because of the uncertainties associated with an accurate determination of the permeability in these regions, a simplified, decoupled procedure is proposed, which reduces the computational complexity. In this procedure, the flow front is advanced using the 2-D formulation. The 2-D formulation also provides the boundary conditions for the subsequent computation of the 3-D flow field without feedback of flow field information to the 2-D model. The governing equations are solved using boundary fitted coordinate systems (BFCS) together with the finite difference method (FDM). Numerical as well as algebraic grid generation and domain decomposition are employed to generate grids that always coincide with the continuously deforming and enlarging flow domain. Results that include the tracking of numerical tracer particles to visualize the three-dimensionality of the flow field are presented for isothermal flow of a Newtonian fluid through a T-joint. This detailed flow field description is expected to form the basis for a rather accurate simulation of quantities that largely depend on the fluid particle pathlines, such as the degree of cure. The method is also extendable to shear-thinning fluids as well as to 3-D flow in the vicinity of the flow front., INTRODUCTION To enhance the thermo-physical properties of polymers, fiber reinforcement preforms can be placed into an empty mold; which is subsequently filled with a resin. Typical resin systems are made [...]

Published
1995

23. FIRST-LINE THERAPY OF T-CELL LYMPHOMA: ALLOGENEIC OR AUTOLOGOUS TRANSPLANTATION FOR CONSOLIDATION - FINAL RESULTS OF THE AATT STUDY

Author

Tournilhac, O., primary, Truemper, L., additional, Ziepert, M., additional, Bouabdallah, K., additional, Nickelsen, M., additional, Maury, S., additional, Reimer, P., additional, Jaccard, A., additional, Herr, W., additional, Wilhelm, M., additional, Cartron, G., additional, Wulf, G., additional, Sanhes, L., additional, Dreger, P., additional, Lamy, T., additional, Kroschinsky, F., additional, Lindemann, H., additional, Roussel, M., additional, Viardot, A., additional, Sibon, D., additional, Delmer, A., additional, De Leval, L., additional, Damaj, G.L., additional, Gisselbrecht, C., additional, Gaulard, P., additional, Rosenwald, A., additional, Friedrichs, B., additional, Altmann, B., additional, and Schmitz, N., additional

Published
2019
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25. A RANDOMIZED PHASE II STUDY OF MB‐CART2019.1 COMPARED TO STANDARD OF CARE IN PATIENTS WITH RELAPSED/REFRACTORY DLBCL INELIGIBLE FOR ASCT – DALY 2‐EU TRIAL.

Author

Borchmann, P., Vandenberghe, P., Urbano‐Ispizua, A., Haiuon, C., Griškevicius, L., Lemonnier, F., Zadoyan, G., Bethke, U., Overstijns, T., Hanssens, L., Bürger, I., Assenmacher, M., Reer, O., Friedrichs, B., Holtkamp, S., Jäger, U., and Kersten, M. J.

Subjects
PATIENT care, CYTOKINE release syndrome
Abstract

B Introduction: b Elderly patients with relapsed or refractory ( I r i / I r i ) diffuse large B-cell lymphoma (DLBCL) represent a distinct patient population with often limited treatment options. A RANDOMIZED PHASE II STUDY OF MB-CART2019.1 COMPARED TO STANDARD OF CARE IN PATIENTS WITH RELAPSED/REFRACTORY DLBCL INELIGIBLE FOR ASCT - DALY 2-EU TRIAL CAR-T cell treatment can offer a curative approach to this comorbid patient population, but data directly comparing standard chemotherapy with CAR-T cell therapy are scarce. [Extracted from the article]

Published
2023
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29. Limited clinical relevance of imaging techniques in the follow-up of patients with advanced chronic lymphocytic leukemia: results of a meta-analysis

Author

Eichhorst, Barbara F, Fischer, Kirsten, Fink, Anna Maria, Elter, Thomas, Wendtner, Clemens M, Goede, Valentin, Bergmann, Manuela, Stilgenbauer, Stephan, Hopfinger, Georg, Ritgen, Matthias, Bahlo, Jasmin, Busch, Raymonde, Hallek, Michael, Oduncu, F, Dreyling, M, Forstpointner, R, Schneller, F, Bogner, C, Peschel, C, Ringshausen, I, Götze, K, Goebeler, Me, Rückle, Lanz, Ritgen, M, Schawitzke, A, Heydrich, B, Kern, K, Böttcher, S, Irmer, S, Strack, U, Borries, V, Klima, Km, Scholz, C, Herold, M, Härtwig, K, Dürig, J, Dührsen, U, Müller Beissenhirtz, H, Noppeney, R, Schüttrumpf, S, Hohloch, K, Binder, C, Hasenkamp, J, Trümper, L, Bäsecke, J, Rieger, M, Witzens Harig, M, Friedrichs, B, Rieger, K, Uharek, L, Kubuschok, B, Murawski, N, Held, G, Zwick, C, Pfreundschuh, M, Fingerle Rowson, G, Reiser, M, Elter, T, Eichhorst, B, Pallasch, C, Hallek, M, Borchmann, P, Hacker, U, Schinkel, S, Wieker, K, Sökler, M, Wolf, Hh, Eucker, J, Staib, P, Schlegel, F, Kropff, M, Kahl, C, Hess, G, Beck, J, Wölfel, T, Bokemeyer, C, Schilling, G, Dierlamm, J, Schüler, F, Busemann, C, Dölken, G, Trendelenburg, Tk, Bühler, A, Stilgenbauer, S, Viardot, A, Greiner, J, Zenz, T, Gaidzik, V, Langer, C, Döhner, H, Werner, I, Dienst, A, Habersang, K, Härtel, N, Leitner, A, Kehrer, G, Middeke, H, Heinisch, K, Adorf, D, Ismer, B, Hering Schubert, C, Jäckle, J, Aulmann, C, Söllner, S, Majunke, P, Fuss, H, Käfer, G, Potenberg, J, Dietrich, G, Hartung, E, Pronath, A, Riedhammer, Fj, Zehrfeld, T, Prümmer, O, Gatter, J, Meier, A, Wattad, M, Heit, W, Sauer, I, Hilgers, K, Geissler, M, Bauer, J, Stein, W, Voigtmann, R, Natt, F, Nickelsen, M, Zeis, M, Schmitz, N, Lange, E, Stoltefuss, A, Schubert, J, Dürk, Ha, Kloke, O, Fauser, A, Roemer, E, Kraut, L, Musch, E, Kohl, S, Link, H, Kirsch, Jf, Schatz, M, Mezger, J, Kempf, B, Heil, G, Derigs, Hg, Roll, C, Kettner, E, Dübbers, Hw, Lutz, L, Hentrich, M, Hoffmann, U, Ibe, M, Falge, C, Schäfer Eckart, K, Rothmann, F, Raghavachar, A, Beckmann, K, Behringer, D, Stauder, H, Hempfling, C, Matzdorff, A, Hähling, D, Kaesberger, Kj, Mück, R, Waladkhani, Ar, Clemens, M, Kraft, J, Ehlert, T, N. N., Schloen, A, Sandritter, B, Scholz, Diekmann, C, Pflüger, Kh, Hausner, G, Fetscher, S, Aulitzky, W, Brugger, W, Frickhofen, N, Fuhr, Lange, C, Lambertz, H, Schulz, L, Schmier, M, Bentz, M, Tauchmann, Gm, Schmidt, M, Meiler, J, Sandmann, M, Kürschner, D, Maier Bay, B, Lindemann, W, Diers, J, Riemeier Sievers, C, Daun, M, Mergenthaler, Hg, Hiller, S, Schirmer, V, Kirchner, H, Langer, W, Günther, B, Gassmann, W, Franke, K, Burghardt, F, Abele, U, Celikel Becker, D, von Weikersthal LF, Brög, G, Hauch, U, Heinrich, B, Brudler, O, Häcker, B, Eckart, Mj, Bolouri, H, Göttler, B, Kindler, M, Zuchold, K, Strohbach, F, Plingen, Ml, Seibt Jung, H, Kirsch, A, Herrenberger, J, Doering, G, von Grünhagen, U, Franke, H, Weniger, J, Kerzel, W, Schmalfeld, M, Rohrberg, R, Hurtz, Hj, Gehbauer, G, Hahnfeld, S, Vehling Kaiser, U, Abenhardt, W, Bosse, D, Böning, L, Schmidt, B, Schick, Hd, Jacobs, G, Stauch, M, Hoffmann, R, Müller, S, Hahn, M, Freier, W, Dietzfelbinger, H, Rassmann, I, Söling, U, Siehl, S, Rudolph, R, Weinert, R, Sauer, A, Meyer, B, Eschenburg, H, Schadeck Gressel, C, Grabenhorst, U, Perker, M, Otremba, B, Reschke, D, Hinrichs, Hf, Zirpel, I, Höring, E, Respondek, M, Köppler, H, Heymanns, J, Weide, R, Hünermund, K, Thiel, C, Reiber, T, Spohn, C, Springer, G, Fiechtner, H, Hübner, A, Kurschel, E, Weiss, J, Schlag, R, Schäfer, E, Hartwich, G, Schmitz, S, Steinmetz, T, Kim, Ts, Lerchenmüller, C, Wehmeyer, J, Laubenstein, Hp, Rendenbach, B, Lebahn, H, Kröning, H, Uhle, R, Balló, H, Gaede, B, Zumbrink, S, Eckert, R, Kamp, T, Reimann, B, Burkhard, O, Mittermüller, J, Hansen, R, Hitz, H, Schliesser, G, Schmitt, Hr, Forstbauer, H, Grundeis, M, Schulze, M, Baldus, M, Lakner, V, Haen, M, Müller, C, Dörfel, S, Göhler, T, Welslau, M, Achtzehn, V, Culmann, H, Gerhardt, S, Ulshöfer, T, Koschuth, A, Schmidt, P, Müller, L, Schneider, M, Koniczek, K, Porowski, P, Glados, M, Knoblich, J, Ben Yehuda, D, Jäger, U, Gaiger, A, Schwarzmeier, J, Nösslinger, T, Smith, M, Patton, N, Gibbons, S, Bouabdallah, R, Gandhi, M, Marlton, P, Mills, T, Angelucci, E, Sorano, Gg, Casula, P, Berneman, Z, Kohser, P, Hudcova Burgetova, A, Machová, R, Papajik, T, Kubová, Z, Fineman, R, Mayer, J, Doubek, M, Brychtova, Y, Ciceri, F, Caligaris Cappio, F, Crocchiolo, R, Dauriac, C, Bernard, M, Escoffre Barbe, M, Lamy, T, Zikesova, E, Karban, J, Salkova, J, Trnený, M, Pytlik, R, Tiley, C, Forsyth, C, Vokurka, S, Koza, V, Van Hoof, A, Selleslag, D, Sebban, C, Baker, B, Belada, D, Jebavy, L, Smolej, L, Pavel, Z, Di Ianni, M, Castaigne, S, Del Poeta, G, Amadori, S, Catalano, J, Ganju, V, Hertzberg, M, Laurenti, L, Dalseg, Am, Bron, D, Morton, J, Durrant, S, Casado, Lf, Theunissen, K, Atias, D, Berkhan, L, Seymour, J, Wolf, M, Bosly, A, Osma Cordoba MM, Portois, C, Jaubert, J, Ferrant, A, Lambert, C, Maerevoet, E, Van den Neste, E, Gadeberg, O, Carney, B, Cannell, P, Eghbali, H, Legouffe, E, Bordessoule, D, Chaury, M, Moreau, S, Pierri, I, Gobbi, M, Berrebi, A, Lishner, M, Yerushazim, R, Yermiaku, T, Kosolov, V, Ambrosetti, Achille, Andreoli, Al, Huguet, F, Laurent, G, Orsucci, L, Forconi, F, Musuraca, G, Zinzani, Pl, Loscertales, J, Mcquillan, A, Cordingley, F, Leahy, M, Cazin, B, Taylor, Mulligan, S, Herbrecht, Cull, G, Seldon, M, Rowlings, P, Ludwig, H, Zojer, N, Solal Céligny, P, Pomponi, F, Savdkova, L, Kozák, T, Christiansen, I, Pérez, I, Campbell, P, Canales Albendea, M, De Paz, R, Arthur, C, Gisselbrecht, C., Eichhorst B.F., Fischer K., Fink A.M., Elter T., Wendtner C.M., Goede V., Bergmann M., Stilgenbauer S., Hopfinger G., Ritgen M., Bahlo J., Busch R., Hallek M., and Zinzani P.L.

Subjects
Male, medicine.medical_specialty, Cyclophosphamide, Chronic lymphocytic leukemia, Immunology, Medizin, Antineoplastic Combined Chemotherapy Protocols, Blood Cell Count, Disease Progression, Disease-Free Survival, Female, Follow-Up Studies, Humans, Leukemia, Lymphocytic, Chronic, B-Cell, Middle Aged, Prognosis, Recurrence, Remission Induction, Tomography, X-Ray Computed, Physical examination, Biochemistry, Chemoimmunotherapy, medicine, Chronic, Tomography, Leukemia, medicine.diagnostic_test, business.industry, B-Cell, Cancer, Cell Biology, Hematology, medicine.disease, Lymphocytic, imaging techniques, X-Ray Computed, Fludarabine, Surgery, chronic lymphocytic leukemia, Radiology, business, Progressive disease, medicine.drug
Abstract

The clinical value of imaging is well established for the follow-up of many lymphoid malignancies but not for chronic lymphocytic leukemia (CLL). A meta-analysis was performed with the dataset of 3 German CLL Study Group phase 3 trials (CLL4, CLL5, and CLL8) that included 1372 patients receiving first-line therapy for CLL. Response as well as progression during follow-up was reassessed according to the National Cancer Institute Working Group1996 criteria. A total of 481 events were counted as progressive disease during treatment or follow-up. Of these, 372 progressions (77%) were detected by clinical symptoms or blood counts. Computed tomography (CT) scans or ultrasound were relevant in 44 and 29 cases (9% and 6%), respectively. The decision for relapse treatment was determined by CT scan or ultrasound results in only 2 of 176 patients (1%). CT scan results had an impact on the prognosis of patients in complete remission only after the administration of conventional chemotherapy but not after chemoimmunotherapy. In conclusion, physical examination and blood count remain the methods of choice for staging and clinical follow-up of patients with CLL as recommended by the International Workshop on Chronic Lymphocytic Leukemia 2008 guidelines. These trials are registered at http://www.isrctn.org as ISRCTN 75653261 and ISRCTN 36294212 and at http://www.clinicaltrials.gov as NCT00281918.

Published
2011

30. A Novel Semi-airborne EM System for Mineral Exploration - First Results from Combined Fluxgate and Induction Coil Data

Author

Nittinger, C., primary, Cherevatova, M., additional, Becken, M., additional, Martin, T., additional, Petersen, H., additional, Steuer, A., additional, Meyer, U., additional, Siemon, B., additional, Matzander, U., additional, Friedrichs, B., additional, Mörbe, W., additional, Yogeshwar, P., additional, Tezkan, B., additional, Rochlitz, R., additional, and Günther, T., additional

Published
2017
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33. Genetic and environmental influences on adult attention deficit hyperactivity disorder symptoms : a large Swedish population-based study of twins

Author

Larsson, Henrik, Asherson, P, Chang, Z, Ljung, T, Friedrichs, B, Larsson, J-O, Lichtenstein, P, Larsson, Henrik, Asherson, P, Chang, Z, Ljung, T, Friedrichs, B, Larsson, J-O, and Lichtenstein, P

Abstract

BACKGROUND: Attention deficit hyperactivity disorder (ADHD) frequently persists into adulthood. Family and twin studies delineate a disorder with strong genetic influences among children and adolescents based on parent- and teacher-reported data but little is known about the genetic and environmental contribution to DSM-IV ADHD symptoms in adulthood. We therefore aimed to investigate the impact of genetic and environmental influences on the inattentive and hyperactive-impulsive symptoms of ADHD in adults. METHOD: Twin methods were applied to self-reported assessments of ADHD symptoms from a large population-based Swedish twin study that included data from 15 198 Swedish male and female twins aged 20 to 46 years. RESULTS: The broad heritability [i.e., A + D, where A is an additive genetic factor and D (dominance) a non-additive genetic factor] was 37% (A = 11%, D = 26%) for inattention and 38% (A = 18%, D = 20%) for hyperactivity-impulsivity. The results also indicate that 52% of the phenotypic correlation between inattention and hyperactivity-impulsivity (r = 0.43) was explained by genetic influences whereas the remaining part of the covariance was explained by non-shared environmental influences. These results were replicated across age strata. CONCLUSIONS: Our findings of moderate broad heritability estimates are consistent with previous literature on self-rated ADHD symptoms in older children, adolescents and adults and retrospective reports of self-rated childhood ADHD by adults but differ from studies of younger children with informant ratings. Future research needs to clarify whether our data indicate a true decrease in the heritability of ADHD in adults compared to children, or whether this relates to the use of self-ratings in contrast to informant data., Funding Agency:Karolinska Institutet Center of Neurodevelopmental Disorders

Published
2013
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34. Einsatz von HTS-DC-SQUIDs in der TEM

Author

Chwala, A. and Friedrichs, B.

Abstract

Wir stellen ein SQUID-Magnetometer-System auf der Basis von Hochtemperatur-Supraleitern vor, das speziell für die Anwendung in der Transienten Elektromagnetik (TEM) entwickelt wurde. Es wird gezeigt, daß Messungen mit SQUID-Magnetometern insbesondere im späten Zeitbereich deutliche Vorteile gegenüber konventionellen Spulen bieten: Spulen messen dB/dt, die zeitliche Ableitung des magnetischen Feldes, welche mit zunehmender Zeit verschwindet; das SQUID misst hingegen B direkt und kann den Transienten solange verfolgen, bis er in dem natürlichen Feldrauschen untergeht. Dadurch kann im Explorationsgeschäft eine erhebliche Kostenersparnis verbunden werden, da mit SQUIDs bei gleicher Signalqualität viel weniger Mittelungen als mit Spulen nötig sind. Andererseits wird mit SQUIDs eine erweiterte Explorationstiefe möglich.

Published
2000

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