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4 results on '"Friedrich Eichert"'

1. 2nd International Congress of the Vascular Access Society / Author Index for Abstracts

Author

Scott J. Hines, Hiromichi Suzuki, Susie Q. Lew, Ester Morelli, J.K. Unger, Paolo Rindi, Takashi Akiba, A. Blumberg, Claudio Ronco, Caitlin E. Carroll, Julia Lepenies, R. Rossaint, Ulrich Frei, Toshio Yamada, Sei Sasaki, N.A. Horn, Yoshihiko Kanno, J C Terrat, Hidetomo Nakamoto, Fabio Galetta, Paul L. Kimmel, Bernard Charra, Mitsuru Arai, Hirokazu Okada, Jean-Marc Hurot, Terry M. Phillips, Kenshi Moriwaki, Ferdinando Franzoni, Giuliano Barsotti, Allen R. Nissenson, Hironori Nemoto, Gary J. Mishkin, Guillaume Jean, Souichi Sugahara, Maria P. Varela, Charles Chazot, Thierry Vanel, Ralf Schindler, Friedrich Eichert, Bernd Klosterhalfen, Adamasco Cupisti, Juan P. Bosch, R Caprioli, Jennifer R. Shapiro, A. Kashefi, and Robert J. Rubin

Subjects
Index (economics), Nephrology, business.industry, International congress, Vascular access, Library science, Medicine, Hematology, General Medicine, business
Published
2001

2. Blood components influence cytokine induction by bacterial substances

Author

Ralf Schindler, Julia Lepenies, Friedrich Eichert, and Ulrich Frei

Subjects
Lipopolysaccharides, Lipopolysaccharide, medicine.medical_treatment, Inflammation, Peripheral blood mononuclear cell, Microbiology, chemistry.chemical_compound, Renal Dialysis, Gram-Negative Bacteria, medicine, Humans, Interleukin 6, Whole blood, Antigens, Bacterial, Immunity, Cellular, biology, Interleukin-6, Interleukin, Hematology, General Medicine, In vitro, Hemodialysis Solutions, Cytokine, Blood, chemistry, Nephrology, biology.protein, Leukocytes, Mononuclear, Cytokines, medicine.symptom, Interleukin-1
Abstract

While some studies clearly demonstrated transfer of cytokine-inducing substances (CIS) through dialysis membranes, other authors were unable to reproduce such a transfer. This inconsistency may have been caused by marked differences in experimental design. We performed a systematic evaluation of cytokine induction in whole blood and from separated peripheral blood mononuclear cells (PBMC) using either purified lipopolysaccharide (LPS) or culture supernatants from various bacterial strains. An in vitro hemodialysis circuit with whole blood in the blood compartment was employed; the dialysate was contaminated with sterile filtrates from Pseudomonas aeruginosa cultures. Addition of plasma samples from the blood side to PBMC readily induced interleukin (IL)-1β and IL-6 after contamination of the dialysate, while the same samples failed to induce cytokine production in whole blood. In experiments using direct incubation, purified P. aeruginosa LPS induced more IL-1β and IL-6 in whole blood compared to PBMC. In contrast, bacterial filtrates from Escherichia coli, Enterobacter cloacae and especially P. aeruginosa induced significantly less cytokines in whole blood compared to PBMC. Addition of erythrocytes but not granulocytes decreased cytokine induction by bacterial filtrates as well as by LPS, probably by adsorption of these substances. The addition of 30% plasma increased cytokine induction by LPS but decreased cytokine induction by P. aeruginosas filtrates. Our results suggest that cellular and plasmatic components of whole blood interact with bacterial CIS altering their pyrogenic activity. The detection of CIS depends on the test system used; whole blood cultures are not as sensitive for the detection of CIS from bacterial filtrates as PBMC cultures.

Published
2001

3. Contents Vol. 19, 2001

Author

J C Terrat, Hidetomo Nakamoto, Fabio Galetta, Susie Q. Lew, Paul L. Kimmel, Ester Morelli, Kenshi Moriwaki, A. Blumberg, Juan P. Bosch, Giuliano Barsotti, Paolo Rindi, Caitlin E. Carroll, R Caprioli, Maria P. Varela, Charles Chazot, Bernd Klosterhalfen, Terry M. Phillips, J.K. Unger, Robert J. Rubin, Scott J. Hines, Hironori Nemoto, Adamasco Cupisti, Hirokazu Okada, Thierry Vanel, Hiromichi Suzuki, Sei Sasaki, Gary J. Mishkin, Yoshihiko Kanno, A. Kashefi, Ralf Schindler, Friedrich Eichert, Bernard Charra, Mitsuru Arai, Guillaume Jean, Souichi Sugahara, R. Rossaint, Toshio Yamada, Takashi Akiba, Jennifer R. Shapiro, Ferdinando Franzoni, Allen R. Nissenson, Claudio Ronco, Ulrich Frei, N.A. Horn, Julia Lepenies, and Jean-Marc Hurot

Subjects
Nephrology, Hematology, General Medicine
Published
2001

4. Subject Index Vol. 19, 2001

Author

Sei Sasaki, Guillaume Jean, Friedrich Eichert, Giuliano Barsotti, Hironori Nemoto, Maria P. Varela, Charles Chazot, R. Rossaint, Scott J. Hines, Paolo Rindi, Thierry Vanel, Yoshihiko Kanno, Gary J. Mishkin, Toshio Yamada, J.K. Unger, Bernard Charra, Mitsuru Arai, Hidetomo Nakamoto, Jennifer R. Shapiro, J C Terrat, Kenshi Moriwaki, Fabio Galetta, Souichi Sugahara, Hiromichi Suzuki, Ulrich Frei, Paul L. Kimmel, N.A. Horn, A. Kashefi, Ferdinando Franzoni, Allen R. Nissenson, Jean-Marc Hurot, Claudio Ronco, Julia Lepenies, Terry M. Phillips, Susie Q. Lew, Ester Morelli, A. Blumberg, Ralf Schindler, Hirokazu Okada, Juan P. Bosch, R Caprioli, Caitlin E. Carroll, Bernd Klosterhalfen, Takashi Akiba, Adamasco Cupisti, and Robert J. Rubin

Subjects
Index (economics), Nephrology, Statistics, Subject (documents), Hematology, General Medicine, Mathematics
Published
2001

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