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5. Recommendations on the structure, personal, and organization of intensive care units

Author

Waydhas, Christian, primary, Riessen, Reimer, additional, Markewitz, Andreas, additional, Hoffmann, Florian, additional, Frey, Lorenz, additional, Böttiger, Bernd W., additional, Brenner, Sebastian, additional, Brenner, Thorsten, additional, Deffner, Teresa, additional, Deininger, Matthias M., additional, Janssens, Uwe, additional, Kluge, Stefan, additional, Marx, Gernot, additional, Schwab, Stefan, additional, Unterberg, Andreas W., additional, Walcher, Felix, additional, and van den Hooven, Thomas, additional

Published
2023
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7. Recommendations on the structure, personal, and organization of intensive care units

Author

Waydhas, Christian, Riessen, Reimer, Markewitz, Andreas, Hoffmann, Florian, Frey, Lorenz, Böttiger, Bernd W., Brenner, Sebastian, Brenner, Thorsten, Deffner, Teresa, Deininger, Matthias M., Janssens, Uwe, Kluge, Stefan, Marx, Gernot, Schwab, Stefan, Unterberg, Andreas W., Walcher, Felix, and van den Hooven, Thomas

Subjects
ddc:610
Abstract

Background: Intensive care units (ICU) are central facilities of medical care in hospitals world-wide and pose a significant financial burden on the health care system. Objectives: To provide guidance and recommendations for the requirements of (infra)structure, personal, and organization of intensive care units. Design and setting: Development of recommendations based on a systematic literature search and a formal consensus process from a group of multidisciplinary and multiprofessional specialists from the German Interdisciplinary Association of Intensive Care and Emergency Medicine (DIVI). The grading of the recommendation follows the report from an American College of Chest Physicians Task Force. Results: The recommendations cover the fields of a 3-staged level of intensive care units, a 3-staged level of care with respect to severity of illness, qualitative and quantitative requirements of physicians and nurses as well as staffing with physiotherapists, pharmacists, psychologists, palliative medicine and other specialists, all adapted to the 3 levels of ICUs. Furthermore, proposals concerning the equipment and the construction of ICUs are supplied. Conclusion: This document provides a detailed framework for organizing and planning the operation and construction/renovation of ICUs.

Published
2023

8. Correction to: Incidence of severe sepsis and septic shock in German intensive care units: the prospective, multicentre INSEP study

Author

Marx, Gernot, Litmathe, Jens, Schulz, Jörg B., Dafotakis, Manuel, Möllhoff, Thomas, Stalljohann, Carolin, Engels, Jonas, Sauerzapfe, Barbara, Stolzenberg, Barbara, Jonas, Engels, Möllhoff, Thomas, Carolin, Stalljohann, Thorben, Beeker, Gernot, Marx, Melanie, Schäfer, Tobias, Schürholz, Ertunc, Altiok, Marx, Nikolaus, Alexander, Kersten, Hannah, Dückers, Alexander, Koch, Trautwein, Christian, Scharf, Alexander, Kreuzer, Ilse, Jaschinski, Ulrich, Kreuzer, Ilse, Jaschinski, Ulrich, Niklas, Markus, Kulzer, Michael, Schlott, Martin, Iberer, Thomas, Stella, Oelert, Thorsten, Löhr, Vandana, Pillai, Praeger, Damaris, Knebel, Fabian, Baumann, Gert, Rosseau, Simone, Schlenk, Florian, Hoffmeister, Bodo, Compton, Friederike, Hoffmann, Clemens, Rademacher, Sibylle, Vietzke, Michael, Jörres, Achim, Meisel, Andreas, Hotter, Benjamin, Mengel, Annerose, Goldmann, Anton, Nöther, Frank, Keh, Didier, Schmidt, Katrin, Angermair, Stefan, Kaffarnik, Magnus, Bubser, Florian, Gummelt, Immo, Vedder, Ina, Bach, Friedhelm, Winter, Markus, Weißer, Frank, Roederer, Marc, Martini, Stefan, Bergmann, Lars, Adamzik, Michael, Baumann, Andreas, Wolf, Britta, Zahn, Peter K., Lehnhardt, Marcus, Daigeler, Adrien, Andreas, Andreas Hohn, Reinhold, Katrin, Adolf, Michael, Altenbeck, Nicole, Gussone, Christoph, Dietrich, Johannes Wolfgang, Köditz, Roland, Putensen, Christian, Schewe, Jens-Christian, Muders, Thomas, Soukup, Jens, Skitek, Kornel, Geisser, Wolfgang, Alber, Andreas, Düthorn, Ludwig, Demund, Josef, Düthorn, Ludwig, Criegern, Isabel v., Nowak, Andreas, Morgenstern, Toralf, Gliniorz, Christoph, Meisner, Michael, Dexel, Melanie, Schütte, Jan Karl, Huppertz-Thyssen, Markus H., Schröder, Stefan, Kowalzik, Ralf, Guel, Cansu, Terhorst, Rainer, Nießen, Peter, Hauschild, Rolf, Mutzek, Elisabeth-Maria, Kogelmann, Klaus, Drüner, Matthias, Jarczak, Dominik, Forster, Christian, Willam, Carsten, Eckardt, K. U., Clemenz, Rüdiger, Siemonsen, Sven, Pauschinger, Matthias, Baumgärtel, Matthias, Muschner, Dorothea, Christ, Michael, Wenzl, Martin, Höhl, Rainer, Junger, Axel, Wöhrle, Armin, Kanthak, Henry, Leschke, Matthias, Kanthak, Henry, Wöhrle, Armin, Leschke, Matthias, Kessler, Paul, Souquet, Jochen, Holfeld, Andreas, Habler, Oliver, Thörner, Markus, Vogt, Oliver, Meybohm, Patrick, Zacharowski, Kai, Lindau, Simone, Lenk, Marcus, Weis, Florian, Schubert, Hermann, Kemnitz, Jürgen, Reckort, Sven, Weikert, Martina, Sudhues, Ulrich, Möller, Stefan, Stefan, Pinger, Domke, Andrea, Wiesenack, Christoph, Schmidt, Florian, Döbel, Kai-Uwe, Moerer, Onnen, Schäper, Jörn, Kernchen, Andrea, Gründling, Matthias, Bollmann, Jan, Kuhn, Sven-Olaf, Kemming, Gregor, Einfeld, Carsten, Sommerer, Thomas, Kemming, Gregor, Einfeld, Carsten, Sommerer, Thomas, Köntges, Philipp, Hinz, Burkhard, Jauch, Lars-Oliver, Selonke, Lutz, Kluge, Stefan, Nierhaus, Axel, de Heer, Geraldine, Gruß, Marco, Köhler, Katja, Brinkmann, Alexander, Fuchs, Thomas, Köberer, Andreas, Geuting, Markus, Weigt, Henry, Baltus, Thomas, Scheltz, Claudia, Bloos, Frank, Reinhart, Konrad, Jegen, Rudolf, Flucht, Marcus, Jürgen, Gburek, Flucht, Marcus, Jegen, Rudolf, Stumm, Anne, Rossenbach, Jannik, Stumm, Anne, Haller, Mathias, Stumm, Anne, Rossenbach, Jannik, Lynch, John, Kempkens, Martin, Buechner, Volkmar, Molitor, Dieter, Klasen, Gerda, Rahmen, Bruno, Muhr, Petra, Canaviri, Patricia, Fiedler, Fritz, Lutz, Jürgen, Kaiser, Marc, Klünter, Simon, Krep, Henning, Anders, Helge, Aduckathil, Sanjay, Sakka, Samir, Reessing, Jan Hinnerk, Aabaid, Sabrina, Löbe, Mathias, Bogatsch, Holger, Löffler, Marcus, Engels, Christoph, Molter, Gerd Peter, Stunz, Michael, Mitrenga, Anja, Geldner, Götz, Bürle, Monica, Klasen, Robert, Werner, Steffanie, Wilhelm, Wolfram, Silke, Frenzel, Juliane, Illert, Jana, Schuttpelz, Briegel, Josef, Möhnle, Patrick, Knorr, Adrian, Hartl, Wolfgang, Ney, Ludwig, Stemmler, Hans-Joachim, Pfister, Hans-Walter, Angstwurm, Matthias, Frey, Lorenz, Irlbeck, Michael, Huge, Volker, Weis, Marion, Kilger, Erich, Hofmann-Kiefer, Klaus, Felbinger, Thomas, Kaufmann, Ines, Goeschl, Julia, Brettner, Franz, Hamm, Heiner, Eife, Claudia, Peckelsen, Claus, Findeisen, Michael, Schmidt-Schridde, Patrick, Kuner, Andreas, Walz, Thomas, Kuner, Barbara, Schrauzer, Thomas, Nentwich, Jens, John, Stefan, Byhahn, Christian, Kretschmer, Thomas, Bergold, Martin N., Weyland, Andreas, Jelschen, Florian, Diers, Anja, Knebel, Frieder G., Kupfer, Thomas, Oppert, Michael, Rohde, Steffen, Möllemann, Angela, Oehmichen, Uwe, Renner, Theresa, Bone, Hans-Georg, Freyhoff, Jörg, Holst, Dana, Birken, Thomas, Henschel, Jörg, Gloger, Martin, Brock, Peter, Klösel, Stephan, Albuszies, Gerd, Schumacher, Detlef, Meierhenrich, Rainer, Schöpp, Alexej, Kuhn, Harald, Riessen, Reimer, Haap, Michael, Ziegler, Silvia, Fastnacht-Böttcher, Jana, Schröder, Rolf Jürgen, Weiss, Manfred, Frank, Katrin, Georgieff, Michael, Weiss, Manfred, Barth, Eberhard, Bracht, Henrik, Ehmcke, Heidrun, Francke, Astrid, Ott, Stefan, Köpcke, Jens, Meyer, Andreas, Jokiel, Gunnar, Freund, Thomas, Schick, Guido, Karassimos, Evagelos, and SepNet Critical Care Trials Group

Published
2017
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9. Hinterlegungserfordernisse im Kontrahierungszwang

Author

Frey, Lorenz

Subjects
300 Sozialwissenschaften::340 Recht::340 Recht, Hinterlegung, Kontrahierungszwang, Hinterlegungserfordernisse
Abstract

Bei dieser rechtswissenschaftlichen Arbeit handelt es sich um eine Doktorarbeit, die im Jahr 2022 von der Freien Universität Berlin angenommen wurde. Sie beschäftigt sich mit dem Rechtsinstitut der Hinterlegung und dabei insbesondere mit der Grenzziehung zwischen der Hinterlegung als Erfüllungssurrogat und der Hinterlegung als Sicherheitsleistung. Aufbauend auf dieser Differenzierung wird untersucht, inwiefern die Hinterlegung im rechtlichen Bereich des Kontrahierungszwangs bereits angewendet wird und - mit Blick auf die Zukunft - angewendet werden könnte. Im Zentrum stehen dabei die Entscheidungen „Orange-Book-Standard“ des Bundesgerichtshofs aus 2011 und „Huawei/ZTE“ des Europäischen Gerichtshofs aus 2015.

Published
2023
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15. Gestose und HELLP-Syndrom

Author

Frey, Lorenz, Bardenheuer, Hubert J., editor, Forst, Helmuth, editor, Larsen, Reinhard, editor, Rossaint, Rolf, editor, and Spahn, Donat R., editor

Published
1998
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29. Abdominal obesity and prolonged prone positioning increase risk of developing sclerosing cholangitis in critically ill patients with influenza A-associated ARDS

Author

Weig Thomas, Schubert Mirjam I, Gruener Norbert, Dolch Michael E, Frey Lorenz, Miller Jens, Johnson Thorsten, and Irlbeck Michael

Subjects
Intraperitoneal fat, Multi-organ dysfunction syndrome, Obesity, Prone position, Sclerosing cholangitis in critically ill patients, Medicine
Abstract

Abstract Background Secondary sclerosing cholangitis is a severe disease of the biliary tract. Over the last decade, several cases of sclerosing cholangitis in critically ill patients (SC-CIP) were reported. Reports in the literature so far are characterized by a wide variety of underlying causes of critical illness, thereby hindering a risk-factor analysis. We report on a homogenous cohort of critically ill patients with influenza A (H1N1) pneumonia and severe acute respiratory distress syndrome (ARDS), of whom a subgroup developed sclerosing cholangitis, allowing for probing of risk factors associated with SC-CIP. Methods Twenty-one patients (5 female, 16 male, 46.3 ± 10.8 years) with severe ARDS due to H1N1 pneumonia were retrospectively divided into two groups, characterized by the presence (n = 5) and absence of SC-CIP (n = 16). A large array of clinical data, laboratory parameters, and multi-detector computed tomography-derived measures were compared. Results Both patient groups showed severe pulmonary impairment. Severity of disease on admission day and during the first 14 days of treatment showed no difference. The patients developing SC-CIP had a higher body mass index (BMI) (37.4 ± 6.0 kg/m2 vs. 29.3 ± 6.8 kg/m2; P = 0.029) and a higher volume of intraperitoneal fat (8273 ± 3659 cm3 vs. 5131 ± 2268 cm3; P = 0.033) and spent a longer cumulative period in the prone position during the first 14 days (165 ± 117 h vs. 78 ± 61 h; P = 0.038). Conclusion Our results suggest that obesity, intraperitoneal fat volume, and a longer cumulative duration spent in the prone position may put patients with ARDS at risk of developing SC-CIP. These results lead us to propose that the prone position should be carefully deployed, particularly in abdominally obese patients, and that frequent checks be made for early hepatic dysfunction.

Published
2012
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30. Delayed intracardial shunting and hypoxemia after massive pulmonary embolism in a patient with a biventricular assist device

Author

Boekstegers Peter, Bruegger Dirk, Frey Lorenz, Dolch Michael E, Weig Thomas, Sodian Ralf, and Irlbeck Michael

Subjects
patent foramen ovale, hypoxemia, pulmonary embolism, ventricle-assist device, heart transplantation, septal occluder device, Surgery, RD1-811, Anesthesiology, RD78.3-87.3
Abstract

Abstract We describe the interdisciplinary management of a 34-year-old woman with dilated cardiomyopathy three months postpartum on a cardiac biventricular assist device (BVAD) as bridge to heart transplantation with delayed onset of intracardial shunting and subsequent hypoxemia due to massive pulmonary embolism. After emergency surgical embolectomy pulmonary function was highly compromised (PaO2/FiO2 54) requiring bifemoral veno-venous extracorporeal membrane oxygenation. Transesophageal echocardiography detected atrial level hypoxemic right-to-left shunting through a patent foramen ovale (PFO). Percutaneous closure of the PFO was achieved with a PFO occluder device. After placing the PFO occluder device oxygenation increased significantly (Δ paO2 119 Torr). The patient received heart transplantation 20 weeks after BVAD implantation and was discharged from ICU 3 weeks after transplantation. An increase in pulmonary vascular resistance in patients on BVAD can reopen a PFO resulting in atrial right-to-left shunting and subsequent hypoxemia. The case demonstrates the usefulness of transesophageal echocardiography examinations in the detection of this unexpected event. Percutaneous placement of a PFO occluder device is an appropriate strategy to stop intracardiac shunting through PFO in fixed elevation of pulmonary vascular resistance.

Published
2011
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33. Role of renal function in risk assessment of target non-attainment after standard dosing of meropenem in critically ill patients

Author

Ehmann, Lisa, Zoller, Michael, Minichmayr, Iris K., Scharf, Christina, Maier, Barbara, Schmitt, Maximilian V., Hartung, Niklas (Dr.), Huisinga, Wilhelm (Prof. Dr.), Vogeser, Michael, Frey, Lorenz, Zander, Johannes, and Kloft, Charlotte (Prof. Dr. rer. nat. habil.)

Subjects
ddc:570, Institut für Biochemie und Biologie
Abstract

Background: Severe bacterial infections remain a major challenge in intensive care units because of their high prevalence and mortality. Adequate antibiotic exposure has been associated with clinical success in critically ill patients. The objective of this study was to investigate the target attainment of standard meropenem dosing in a heterogeneous critically ill population, to quantify the impact of the full renal function spectrum on meropenem exposure and target attainment, and ultimately to translate the findings into a tool for practical application. Methods: A prospective observational single-centre study was performed with critically ill patients with severe infections receiving standard dosing of meropenem. Serial blood samples were drawn over 4 study days to determine meropenem serum concentrations. Renal function was assessed by creatinine clearance according to the Cockcroft and Gault equation (CLCRCG). Variability in meropenem serum concentrations was quantified at the middle and end of each monitored dosing interval. The attainment of two pharmacokinetic/pharmacodynamic targets (100% T->MIC, 50% T->4xMIC) was evaluated for minimum inhibitory concentration (MIC) values of 2 mg/L and 8 mg/L and standard meropenem dosing (1000 mg, 30-minute infusion, every 8 h). Furthermore, we assessed the impact of CLCRCG on meropenem concentrations and target attainment and developed a tool for risk assessment of target non-attainment. Results: Large inter-and intra-patient variability in meropenem concentrations was observed in the critically ill population (n = 48). Attainment of the target 100% T->MIC was merely 48.4% and 20.6%, given MIC values of 2 mg/L and 8 mg/L, respectively, and similar for the target 50% T->4xMIC. A hyperbolic relationship between CLCRCG (25-255 ml/minute) and meropenem serum concentrations at the end of the dosing interval (C-8h) was derived. For infections with pathogens of MIC 2 mg/L, mild renal impairment up to augmented renal function was identified as a risk factor for target non-attainment (for MIC 8 mg/L, additionally, moderate renal impairment). Conclusions: The investigated standard meropenem dosing regimen appeared to result in insufficient meropenem exposure in a considerable fraction of critically ill patients. An easy-and free-to-use tool (the MeroRisk Calculator) for assessing the risk of target non-attainment for a given renal function and MIC value was developed.

Published
2017

38. Additional file 3: of Role of renal function in risk assessment of target non-attainment after standard dosing of meropenem in critically ill patients: a prospective observational study

Author

Ehmann, Lisa, Zoller, Michael, Minichmayr, Iris, Scharf, Christina, Maier, Barbara, Schmitt, Maximilian, Hartung, Niklas, Huisinga, Wilhelm, Vogeser, Michael, Frey, Lorenz, Zander, Johannes, and Kloft, Charlotte

Abstract

PK/PD target attainment.pdf. (PDF 65 kb)

Published
2017
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39. Additional file 1: of Role of renal function in risk assessment of target non-attainment after standard dosing of meropenem in critically ill patients: a prospective observational study

Author

Ehmann, Lisa, Zoller, Michael, Minichmayr, Iris, Scharf, Christina, Maier, Barbara, Schmitt, Maximilian, Hartung, Niklas, Huisinga, Wilhelm, Vogeser, Michael, Frey, Lorenz, Zander, Johannes, and Kloft, Charlotte

Subjects
ComputingMethodologies_DOCUMENTANDTEXTPROCESSING
Abstract

Study design.pdf. (PDF 170 kb)

Published
2017
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40. Additional file 2: of Role of renal function in risk assessment of target non-attainment after standard dosing of meropenem in critically ill patients: a prospective observational study

Author

Ehmann, Lisa, Zoller, Michael, Minichmayr, Iris, Scharf, Christina, Maier, Barbara, Schmitt, Maximilian, Hartung, Niklas, Huisinga, Wilhelm, Vogeser, Michael, Frey, Lorenz, Zander, Johannes, and Kloft, Charlotte

Abstract

Regression model for risk calculation.pdf. (PDF 475 kb)

Published
2017
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41. Quantification of Adipose Tissue and Muscle Mass Based on Computed Tomography Scans: Comparison of Eight Planimetric and Diametric Techniques Including a Step-By-Step Guide

Author

Irlbeck, Thomas, primary, Janitza, Silke, additional, Poros, Balázs, additional, Golebiewski, Monika, additional, Frey, Lorenz, additional, Paprottka, Philipp M., additional, da Silva, Teresa, additional, Irlbeck, Michael, additional, Böcker, Wolfgang, additional, and Weig, Thomas, additional

Published
2018
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42. Role of renal function in risk assessment of target non-attainment after standard dosing of meropenem in critically ill patients: a prospective observational study

Author

Ehmann, Lisa, primary, Zoller, Michael, additional, Minichmayr, Iris K., additional, Scharf, Christina, additional, Maier, Barbara, additional, Schmitt, Maximilian V., additional, Hartung, Niklas, additional, Huisinga, Wilhelm, additional, Vogeser, Michael, additional, Frey, Lorenz, additional, Zander, Johannes, additional, and Kloft, Charlotte, additional

Published
2017
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46. Optimization of linezolid therapy in the critically ill: the effect of adjusted infusion regimens

Author

Taubert, Max, Zander, Johannes, Frechen, Sebastian, Scharf, Christina, Frey, Lorenz, Vogeser, Michael, Fuhr, Uwe, Zoller, Michael, Taubert, Max, Zander, Johannes, Frechen, Sebastian, Scharf, Christina, Frey, Lorenz, Vogeser, Michael, Fuhr, Uwe, and Zoller, Michael

Abstract

Objectives: Insufficient linezolid levels, which are associated with a poorer outcome, are often observed in ICU patients who receive standard dosing. Although strategies to overcome these insufficient levels have been discussed, appropriate alternative dosing regimens remain to be identified. Methods: Various infusion regimens (1200-3600 mg/day; q6h, q8h, q12h and continuous) were simulated in 67000 ICU patients. The probability of attaining pharmacodynamic targets (T > MIC >= 85%, AUC/MIC >= 100, cumulative fraction of response for Staphylococcus aureus and Enterococcus spp., PTA for an MIC of 0.5-4 mg/L) as well as the avoidance of toxic concentrations and concentrations constantly below the MIC (lack of antibiotic effect) or inside amutant selection window (resistance development) were evaluated. Results: Best target attainment according to T > MIC was observed for continuous infusions, followed by q6h, q8h and q12h. A substantially reduced target attainment was observed in patients with acute respiratory distress syndrome (ARDS). In patients without ARDS, 1200 mg/day was insufficient irrespective of the regimen, while a dose of 1400 mg/day administered q6h or by continuous infusions provided an acceptable target attainment (e.g. cumulative fraction of response with regards to T > MIC >= 93%). Higher rates of potentially toxic trough concentrations (28% versus 12%) and concentrations constantly inside the mutant selection window (15% versus, 0.1%) were observed with continuous infusions compared with q6h infusions (1400 mg/day, patients without ARDS). Conclusions: Irrespective of the regimen, 1200 mg/day linezolid might be insufficient for the treatment of ICU patients. Patients without ARDS might particularly benefit from q6h infusions with increased daily doses (e.g. 1400mg/day).

Published
2017

47. Predictors of Inadequate Linezolid Concentrations after Standard Dosing in Critically Ill Patients

Author

Taubert, Max, Zoller, Michael, Maier, Barbara, Frechen, Sebastian, Scharf, Christina, Holdt, Lesca-Miriam, Frey, Lorenz, Vogeser, Michael, Fuhr, Uwe, Zander, Johannes, Taubert, Max, Zoller, Michael, Maier, Barbara, Frechen, Sebastian, Scharf, Christina, Holdt, Lesca-Miriam, Frey, Lorenz, Vogeser, Michael, Fuhr, Uwe, and Zander, Johannes

Abstract

Adequate linezolid blood concentrations have been shown to be associated with an improved clinical outcome. Our goal was to assess new predictors of inadequate linezolid concentrations often observed in critically ill patients. Fifty-two critically ill patients with severe infections receiving standard dosing of linezolid participated in this prospective observational study. Serum samples (median, 32 per patient) were taken on four consecutive days, and total linezolid concentrations were quantified. Covariates influencing linezolid pharmacokinetics were identified by multivariate analysis and a population pharmacokinetic model. Target attainment (area under the concentration-time curve over 12 h [AUC(12)]/MIC ratio of>50; MIC = 2 mg/liter) was calculated for both the study patients and a simulated independent patient group (n = 67,000). Target attainment was observed for only 36% of the population on both days 1 and 4. Independent covariates related to significant decreases of linezolid concentrations included higher weight, creatinine clearance rates, and fibrinogen and antithrombin concentrations, lower concentrations of lactate, and the presence of acute respiratory distress syndrome (ARDS). Linezolid clearance was increased in ARDS patients (by 82%) and in patients with elevated fibrinogen or decreased lactate concentrations. In simulated patients, most covariates, including fibrinogen and lactate concentrations and weight, showed quantitatively minor effects on target attainment (difference of <= 9% between the first and fourth quartiles of the respective parameters). In contrast, the presence of ARDS had the strongest influence, with only <= 6% of simulated patients reaching this target. In conclusion, the presence of ARDS was identified as a new and strong predictor of insufficient linezolid concentrations, which might cause treatment failure. Insufficient concentrations might also be a major problem in patients with combined alterations of other covariate p

Published
2016

50. Buchbesprechungen

Author

Kirchgraber, U., Struwe, Michael, Gut, J., Schneebeli, H. R., Schneebeli, H. R., van den Berg, B., Schwarz, H. R., Baltensperger, W., Scheurle, Jürgen, Frey, Lorenz, Schneebeli, H. R., and Ruf, Bernhard

Published
1988
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