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611 results on '"Freund, Yonathan"'

1. Effect of the 1-h bundle on mortality in patients with suspected sepsis in the emergency department: a stepped wedge cluster randomized clinical trial

Author

Freund, Yonathan, Cancella de Abreu, Marta, Lebal, Soufiane, Rousseau, Alexandra, Lafon, Thomas, Yordanov, Youri, Macrez, Richard, Coisy, Fabien, Le Borgne, Pierrick, Femy, Florent, Douillet, Delphine, Boter, Neus Robert, Eyer, Xavier, Bouillon-Minois, Jean-Baptiste, Ogereau, Carl, Bouzid, Donia, Goulet, Hélène, Roussel, Mélanie, Rousseau, Geoffroy, Guénézan, Jeremy, Occelli, Celine, Chouihed, Tahar, Osorio Quispe, Gina, Renard, Marine Clea, Gorlicki, Judith, Bloom, Ben, Simon, Tabassome, and Gerlier, Camille

Published
2024
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4. Correction: Effect of the 1-h bundle on mortality in patients with suspected sepsis in the emergency department: a stepped wedge cluster randomized clinical trial

Author

Freund, Yonathan, Cancella de Abreu, Marta, Lebal, Soufiane, Rousseau, Alexandra, Lafon, Thomas, Yordanov, Youri, Macrez, Richard, Coisy, Fabien, Le Borgne, Pierrick, Femy, Florent, Douillet, Delphine, Boter, Neus Robert, Eyer, Xavier, Bouillon-Minois, Jean-Baptiste, Ogereau, Carl, Bouzid, Donia, Goulet, Hélène, Roussel, Mélanie, Rousseau, Geoffroy, Guénézan, Jeremy, Occelli, Celine, Chouihed, Tahar, Osorio Quispe, Gina, Renard, Marine Clea, Gorlicki, Judith, Bloom, Ben, Simon, Tabassome, and Gerlier, Camille

Published
2024
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6. Accuracy of physicians’ intuitive risk estimation in the diagnostic management of pulmonary embolism: an individual patient data meta-analysis

Author

van Maanen, Rosanne, Martens, Emily S.L., Takada, Toshihiko, Roy, Pierre-Marie, de Wit, Kerstin, Parpia, Sameer, Kraaijpoel, Noémie, Huisman, Menno V., Wells, Philip S., Le Gal, Grégoire, Righini, Marc, Freund, Yonathan, Galipienzo, Javier, van Es, Nick, Blom, Jeanet W., Moons, Karel G.M., Rutten, Frans H., van Smeden, Maarten, Klok, Frederikus A., Geersing, Geert-Jan, and Luijken, Kim

Published
2023
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10. Effect of intravenous almitrine on intubation or mortality in patients with COVID-19 acute hypoxemic respiratory failure: A multicentre, randomised, double-blind, placebo-controlled trial

Author

Kalfon, Pierre, Payen, Jean-François, Rousseau, Alexandra, Chousterman, Benjamin, Cachanado, Marine, Tibi, Annick, Audibert, Juliette, Depret, François, Constantin, Jean-Michel, Weiss, Emmanuel, Remerand, Francis, Freund, Yonathan, Simon, Tabassome, and Riou, Bruno

Published
2022
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11. Pulmonary embolism severity and in-hospital mortality: An international comparative study between COVID-19 and non-COVID patients

Author

Miró, Òscar, Jiménez, Sònia, Llorens, Pere, Roussel, Melanie, Gorlicki, Judith, García-Lamberechts, Eric Jorge, Le Borgne, Pierrick, Jacob, Javier, Chauvin, Anthony, Lucidarme, Olivier, Burillo-Putze, Guillermo, Aguirre, Alfons, Brigant, Fabien, Lozano, Laura, González del Castillo, Juan, and Freund, Yonathan

Published
2022
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17. Effect of Noninvasive Airway Management of Comatose Patients With Acute Poisoning

Author

Freund, Yonathan, primary, Viglino, Damien, additional, Cachanado, Marine, additional, Cassard, Clémentine, additional, Montassier, Emmanuel, additional, Douay, Bénedicte, additional, Guenezan, Jérémy, additional, Le Borgne, Pierrick, additional, Yordanov, Youri, additional, Severin, Armelle, additional, Roussel, Mélanie, additional, Daniel, Matthieu, additional, Marteau, Adrien, additional, Peschanski, Nicolas, additional, Teissandier, Dorian, additional, Macrez, Richard, additional, Morere, Julia, additional, Chouihed, Tahar, additional, Roux, Damien, additional, Adnet, Frédéric, additional, Bloom, Ben, additional, Chauvin, Anthony, additional, and Simon, Tabassome, additional

Published
2023
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20. Time-pattern of adverse outcomes after an infection-triggered acute heart failure decompensation and the influence of early antibiotic administration and hospitalisation: results of the PAPRICA-3 study

Author

Miró, Òscar, Takagi, Koji, Gayat, Étienne, Gil, Víctor, Llorens, Pere, Martín-Sánchez, Francisco J., Jacob, Javier, Herrero-Puente, Pablo, Escoda, Rosa, Pilar López-Díez, María, Valero, Amparo, Fuentes, Marta, Garrido, José M., Salvo, Eva, Rizzi, Miguel A., Aguirre, Alfons, Travería Bécquer, Lissete, Domínguez-Rodríguez, Alberto, Padrosa, Joan, Martínez, Gemma, Arrigo, Mattia, Freund, Yonathan, and Mebazaa, Alexandre

Published
2020
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22. Diagnostic management of acute pulmonary embolism: a prediction model based on a patient data meta-analysis

Author

van Es, Nick, primary, Takada, Toshihiko, additional, Kraaijpoel, Noémie, additional, Klok, Frederikus A, additional, Stals, Milou A M, additional, Büller, Harry R, additional, Courtney, D Mark, additional, Freund, Yonathan, additional, Galipienzo, Javier, additional, Le Gal, Grégoire, additional, Ghanima, Waleed, additional, Huisman, Menno V, additional, Kline, Jeffrey A, additional, Moons, Karel G M, additional, Parpia, Sameer, additional, Perrier, Arnaud, additional, Righini, Marc, additional, Robert-Ebadi, Helia, additional, Roy, Pierre-Marie, additional, Wells, Phil S, additional, de Wit, Kerstin, additional, van Smeden, Maarten, additional, and Geersing, Geert-Jan, additional

Published
2023
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24. Ruling out pulmonary embolism across different healthcare settings: A systematic review and individual patient data meta-analysis

Author

Geersing, Geert-Jan, Takada, Toshihiko, Klok, Frederikus A., Büller, Harry R., Courtney, D. Mark, Freund, Yonathan, Galipienzo, Javier, Le Gal, Gregoire, Ghanima, Waleed, Kline, Jeffrey A., Huisman, Menno V., Moons, Karel G. M., Perrier, Arnaud, Parpia, Sameer, Robert-Ebadi, Helia, Righini, Marc, Roy, Pierre-Marie, van Smeden, Maarten, Stals, Milou A. M., Wells, Philip S., de Wit, Kerstin, Kraaijpoel, Noémie, and van Es, Nick

Subjects
Pulmonary embolism -- Diagnosis, Diagnosis -- Comparative analysis -- Evaluation, Biological sciences
Abstract

Background The challenging clinical dilemma of detecting pulmonary embolism (PE) in suspected patients is encountered in a variety of healthcare settings. We hypothesized that the optimal diagnostic approach to detect these patients in terms of safety and efficiency depends on underlying PE prevalence, case mix, and physician experience, overall reflected by the type of setting where patients are initially assessed. The objective of this study was to assess the capability of ruling out PE by available diagnostic strategies across all possible settings. Methods and findings We performed a literature search (MEDLINE) followed by an individual patient data (IPD) meta-analysis (MA; 23 studies), including patients from self-referral emergency care (n = 12,612), primary healthcare clinics (n = 3,174), referred secondary care (n = 17,052), and hospitalized or nursing home patients (n = 2,410). Multilevel logistic regression was performed to evaluate diagnostic performance of the Wells and revised Geneva rules, both using fixed and adapted D-dimer thresholds to age or pretest probability (PTP), for the YEARS algorithm and for the Pulmonary Embolism Rule-out Criteria (PERC). All strategies were tested separately in each healthcare setting. Following studies done in this field, the primary diagnostic metrices estimated from the models were the 'failure rate' of each strategy-i.e., the proportion of missed PE among patients categorized as 'PE excluded' and 'efficiency'-defined as the proportion of patients categorized as 'PE excluded' among all patients. In self-referral emergency care, the PERC algorithm excludes PE in 21% of suspected patients at a failure rate of 1.12% (95% confidence interval [CI] 0.74 to 1.70), whereas this increases to 6.01% (4.09 to 8.75) in referred patients to secondary care at an efficiency of 10%. In patients from primary healthcare and those referred to secondary care, strategies adjusting D-dimer to PTP are the most efficient (range: 43% to 62%) at a failure rate ranging between 0.25% and 3.06%, with higher failure rates observed in patients referred to secondary care. For this latter setting, strategies adjusting D-dimer to age are associated with a lower failure rate ranging between 0.65% and 0.81%, yet are also less efficient (range: 33% and 35%). For all strategies, failure rates are highest in hospitalized or nursing home patients, ranging between 1.68% and 5.13%, at an efficiency ranging between 15% and 30%. The main limitation of the primary analyses was that the diagnostic performance of each strategy was compared in different sets of studies since the availability of items used in each diagnostic strategy differed across included studies; however, sensitivity analyses suggested that the findings were robust. Conclusions The capability of safely and efficiently ruling out PE of available diagnostic strategies differs for different healthcare settings. The findings of this IPD MA help in determining the optimum diagnostic strategies for ruling out PE per healthcare setting, balancing the trade-off between failure rate and efficiency of each strategy., Author(s): Geert-Jan Geersing 1,*, Toshihiko Takada 1,2, Frederikus A. Klok 3, Harry R. Büller 4, D. Mark Courtney 5, Yonathan Freund 6, Javier Galipienzo 7, Gregoire Le Gal 8, Waleed [...]

Published
2022
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28. Covariate-specific ROC curve analysis can accommodate differences between covariate subgroups in the evaluation of diagnostic accuracy

Author

Lee, Jenny, primary, van Es, Nick, additional, Takada, Toshihiko, additional, Klok, Frederikus A., additional, Geersing, Geert-Jan, additional, Blume, Jeffrey, additional, Bossuyt, Patrick M., additional, Büller, Harry R., additional, Courtney, D Mark, additional, Freund, Yonathan, additional, Galipienzo, Javier, additional, Le Gal, Gregoire, additional, Ghanima, Waleed, additional, Kline, Jeffrey A., additional, Huisman, Menno V., additional, Moons, Karel G.M., additional, Perrier, Arnaud, additional, Parpia, Sameer, additional, Robert-Ebadi, Helia, additional, Righini, Marc, additional, Roy, Pierre-Marie, additional, van Smeden, Maarten, additional, Stals, Milou A.M., additional, Wells, Philip S., additional, de Wit, Kerstin, additional, and Kraaijpoel, Noémie, additional

Published
2023
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32. Outcomes of Omicron sub-lineages BA.1.1 and BA.2 infection compared with the sub-lineage BA.1 infection in emergency departments' patients

Author

Bouzid, Donia, primary, Kapfer, Thomas, additional, Marot, Stéphane, additional, Ing, Vittiaroat, additional, Ferré, Valentine Marie, additional, Chauvin, Anthony, additional, Le Goff, Jérôme, additional, Ellouze, Sami, additional, Salmona, Maud, additional, Hermand, Christelle, additional, Bourg, Arthur, additional, Schnuriger, Aurélie, additional, Fémy, Florent, additional, Van Tinh, Méryl Nguyen, additional, Brichler, Ségolène, additional, Veyer, David, additional, Le Borgne, Pierrick, additional, Fafi-Kremer, Samira, additional, L'Honneur, Anne Sophie, additional, Augustin, Clément, additional, Simon, Tabassome, additional, Cachanado, Marine, additional, and Freund, Yonathan, additional

Published
2023
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41. Effects of the intensity of prehospital treatment on short-term outcomes in patients with acute heart failure: the SEMICA-2 study

Author

Miró, Òscar, Hazlitt, Melissa, Escalada, Xavier, Llorens, Pere, Gil, Víctor, Martín-Sánchez, Francisco Javier, Harjola, Pia, Rico, Verónica, Herrero-Puente, Pablo, Jacob, Javier, Cone, David C., Möckel, Martin, Christ, Michael, Freund, Yonathan, di Somma, Salvatore, Laribi, Said, Mebazaa, Alexandre, Harjola, Veli-Pekka, and On behalf of the ICA-SEMES Research Group

Published
2018
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45. Early variation of quick sequential organ failure assessment score to predict in-hospital mortality in emergency department patients with suspected infection

Author

Lemachatti, Najla, Ortega, Mar, Penaloza, Andrea, Le Borgne, Pierrick, Claret, Pierre-Géraud, Occelli, Céline, Truchot, Jennifer, Dumas, Florence, Feral-Pierssens, Anne-Laure, Andrianjafy, Héry, Beaune, Sebastien, Yordanov, Youri, Hausfater, Pierre, Riou, Bruno, Bloom, Ben, Krastinova, Evguenia, and Freund, Yonathan

Published
2019
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47. Overnight Stay in the Emergency Department and Mortality in Older Patients

Author

Roussel, Melanie, Teissandier, Dorian, Yordanov, Youri, Balen, Frederic, Noizet, Marc, Tazarourte, Karim, Bloom, Ben, Catoire, Pierre, Berard, Laurence, Cachanado, Marine, Simon, Tabassome, Laribi, Said, and Freund, Yonathan

Abstract

IMPORTANCE: Patients in the emergency department (ED) who are waiting for hospital admission on a wheeled cot may be subject to harm. However, mortality and morbidity among older patients who spend the night in the ED while waiting for a bed in a medical ward are unknown. OBJECTIVE: To assess whether older adults who spend a night in the ED waiting for admission to a hospital ward are at increased risk of in-hospital mortality. DESIGN, SETTINGS, AND PARTICIPANTS: This was a prospective cohort study of older patients (≥75 years) who visited the ED and were admitted to the hospital on December 12 to 14, 2022, at 97 EDs across France. Two groups were defined and compared: those who stayed in the ED from midnight until 8:00 am (ED group) and those who were admitted to a ward before midnight (ward group). MAIN OUTCOMES AND MEASURES: The primary end point was in-hospital mortality, truncated at 30 days. Secondary outcomes included in-hospital adverse events (ie, falls, infection, bleeding, myocardial infarction, stroke, thrombosis, bedsores, and dysnatremia) and hospital length of stay. A generalized linear-regression mixed model was used to compare end points between groups. RESULTS: The total sample comprised 1598 patients (median [IQR] age, 86 [80-90] years; 880 [55%] female and 718 [45%] male), with 707 (44%) in the ED group and 891 (56%) in the ward group. Patients who spent the night in the ED had a higher in-hospital mortality rate of 15.7% vs 11.1% (adjusted risk ratio [aRR], 1.39; 95% CI, 1.07-1.81). They also had a higher risk of adverse events compared with the ward group (aRR, 1.24; 95% CI, 1.04-1.49) and increased median length of stay (9 vs 8 days; rate ratio, 1.20; 95% CI, 1.11-1.31). In a prespecified subgroup analysis of patients who required assistance with the activities of daily living, spending the night in the ED was associated with a higher in-hospital mortality rate (aRR, 1.81; 95% CI, 1.25-2.61). CONCLUSIONS AND RELEVANCE: The findings of this prospective cohort study indicate that for older patients, waiting overnight in the ED for admission to a ward was associated with increased in-hospital mortality and morbidity, particularly in patients with limited autonomy. Older adults should be prioritized for admission to a ward.

Published
2023
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49. Diagnostic management of acute pulmonary embolism: a prediction model based on a patient data meta-analysis.

Author

Es, Nick van, Takada, Toshihiko, Kraaijpoel, Noémie, Klok, Frederikus A, Stals, Milou A M, Büller, Harry R, Courtney, D Mark, Freund, Yonathan, Galipienzo, Javier, Gal, Grégoire Le, Ghanima, Waleed, Huisman, Menno V, Kline, Jeffrey A, Moons, Karel G M, Parpia, Sameer, Perrier, Arnaud, Righini, Marc, Robert-Ebadi, Helia, Roy, Pierre-Marie, and Wells, Phil S

Subjects
PULMONARY embolism, CLINICAL prediction rules, NURSING home patients, PREDICTION models, VENOUS thrombosis, THROMBOEMBOLISM, SYMPTOMS
Abstract

Aims Risk stratification is used for decisions regarding need for imaging in patients with clinically suspected acute pulmonary embolism (PE). The aim was to develop a clinical prediction model that provides an individualized, accurate probability estimate for the presence of acute PE in patients with suspected disease based on readily available clinical items and D-dimer concentrations. Methods and results An individual patient data meta-analysis was performed based on sixteen cross-sectional or prospective studies with data from 28 305 adult patients with clinically suspected PE from various clinical settings, including primary care, emergency care, hospitalized and nursing home patients. A multilevel logistic regression model was built and validated including ten a priori defined objective candidate predictors to predict objectively confirmed PE at baseline or venous thromboembolism (VTE) during follow-up of 30 to 90 days. Multiple imputation was used for missing data. Backward elimination was performed with a P -value <0.10. Discrimination (c-statistic with 95% confidence intervals [CI] and prediction intervals [PI]) and calibration (outcome:expected [O:E] ratio and calibration plot) were evaluated based on internal-external cross-validation. The accuracy of the model was subsequently compared with algorithms based on the Wells score and D-dimer testing. The final model included age (in years), sex, previous VTE, recent surgery or immobilization, haemoptysis, cancer, clinical signs of deep vein thrombosis, inpatient status, D-dimer (in µg/L), and an interaction term between age and D-dimer. The pooled c-statistic was 0.87 (95% CI, 0.85–0.89; 95% PI, 0.77–0.93) and overall calibration was very good (pooled O:E ratio, 0.99; 95% CI, 0.87–1.14; 95% PI, 0.55–1.79). The model slightly overestimated VTE probability in the lower range of estimated probabilities. Discrimination of the current model in the validation data sets was better than that of the Wells score combined with a D-dimer threshold based on age (c-statistic 0.73; 95% CI, 0.70–0.75) or structured clinical pretest probability (c-statistic 0.79; 95% CI, 0.76–0.81). Conclusion The present model provides an absolute, individualized probability of PE presence in a broad population of patients with suspected PE, with very good discrimination and calibration. Its clinical utility needs to be evaluated in a prospective management or impact study. Registration PROSPERO ID 89366. [ABSTRACT FROM AUTHOR]

Published
2023
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