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2. Coulomb dissociation of $^{20,21}$N

Author

Röder, Marko, Adachi, Tatsuya, Aksyutina, Yulia, Alcantara, Juan, Altstadt, Sebastian, Alvarez-Pol, Hector, Ashwood, Nicholas, Atar, Leyla, Aumann, Thomas, Avdeichikov, Vladimir, Barr, M., Beceiro, Saul, Bemmerer, Daniel, Benlliure, Jose, Bertulani, Carlos, Boretzky, Konstanze, Borge, Maria J. G., Burgunder, G., Caamano, Manuel, Caesar, Christoph, Casarejos, Enrique, Catford, Wilton, Cederkall, Joakim, Chakraborty, S., Chartier, Marielle, Chulkov, Leonid, Cortina-Gil, Dolores, Crespo, Raquel, Pramanik, Ushasi Datta, Diaz-Fernandez, Paloma, Dillmann, Iris, Elekes, Zoltan, Enders, Joachim, Ershova, Olga, Estrade, A., Farinon, F., Fraile, Luis M., Freer, Martin, Freudenberger, M., Fynbo, Hans, Galaviz, Daniel, Geissel, Hans, Gernhäuser, Roman, Göbel, Kathrin, Golubev, Pavel, Diaz, Diego Gonzalez, Hagdahl, Julius, Heftrich, Tanja, Heil, Michael, Heine, Marcel, Heinz, Andreas, Henriques, Ana, Holl, Matthias, Ickert, G., Ignatov, Alexander, Jakobsson, Bo, Johansson, Hakan, Jonson, Björn, Kalantar-Nayestanaki, Nasser, Kanungo, Rituparna, Kelic-Heil, Aleksandra, Knöbel, Ronja, Kröll, Thorsten, Krücken, Reiner, Kurcewicz, J., Kurz, Nikolaus, Labiche, Marc, Langer, Christoph, Bleis, Tudi Le, Lemmon, Roy, Lepyoshkina, Olga, Lindberg, Simon, Machado, Jorge, Marganiec, Justyna, Caro, Magdalena Mostazo, Movsesyan, Alina, Najafi, Mohammad Ali, Nilsson, Thomas, Nociforo, Chiara, Panin, Valerii, Paschalis, Stefanos, Perea, Angel, Petri, Marina, Pietri, S., Plag, Ralf, Prochazka, A., Rahaman, Md. Anisur, Rastrepina, Ganna, Reifarth, Rene, Ribeiro, Guillermo, Ricciardi, M. Valentina, Rigollet, Catherine, Riisager, Karsten, Rossi, Dominic, Saez, Jose Sanchez del Rio, Savran, Deniz, Scheit, Heiko, Simon, Haik, Sorlin, Olivier, Stoica, V., Streicher, Branislav, Taylor, Jon, Tengblad, Olof, Terashima, Satoru, Thies, Ronja, Togano, Yasuhiro, Uberseder, Ethan, Van de Walle, J., Velho, Paulo, Volkov, Vasily, Wagner, Andreas, Wamers, Felix, Weick, Helmut, Weigand, Mario, Wheldon, Carl, Wilson, G., Wimmer, Christine, Winfield, J. S., Woods, Philip, Yakorev, Dmitry, Zhukov, Mikhail, Zilges, Andreas, and Zuber, Kai

Subjects
Nuclear Experiment
Abstract

Neutron-rich light nuclei and their reactions play an important role for the creation of chemical elements. Here, data from a Coulomb dissociation experiment on $^{20,21}$N are reported. Relativistic $^{20,21}$N ions impinged on a lead target and the Coulomb dissociation cross section was determined in a kinematically complete experiment. Using the detailed balance theorem, the $^{19}\mathrm{N}(\mathrm{n},\gamma)^{20}\mathrm{N}$ and $^{20}\mathrm{N}(\mathrm{n},\gamma)^{21}\mathrm{N}$ excitation functions and thermonuclear reaction rates have been determined. The $^{19}\mathrm{N}(\mathrm{n},\gamma)^{20}\mathrm{N}$ rate is up to a factor of 5 higher at $T<1$\,GK with respect to previous theoretical calculations, leading to a 10\,\% decrease in the predicted fluorine abundance.

Published
2016
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3. Determination of the Neutron-Capture Rate of 17C for the R-process Nucleosynthesis

Author

Heine, M., Typel, S., Wu, M. -R., Adachi, T., Aksyutina, Y., Alcantara, J., Altstadt, S., Alvarez-Pol, H., Ashwood, N., Aumann, T., Avdeichikov, V., Barr, M., Beceiro-Novo, S., Bemmerer, D., Benlliure, J., Bertulani, C. A., Boretzky, K., Borge, M. J. G., Burgunder, G., Caamano, M., Caesar, C., Casarejos, E., Catford, W., Cederkäll, J., Chakraborty, S., Chartier, M., Chulkov, L. V., Cortina-Gil, D., Crespo, R., Pramanik, U. Datta, Fernandez, P. Diaz, Dillmann, I., Elekes, Z., Enders, J., Ershova, O., Estrade, A., Farinon, F., Fraile, L. M., Freer, M., Freudenberger, M., Fynbo, H. O. U., Galaviz, D., Geissel, H., Gernhäuser, R., Göbel, K., Golubev, P., Diaz, D. Gonzalez, Hagdahl, J., Heftrich, T., Heil, M., Heinz, A., Henriques, A., Holl, M., Ickert, G., Ignatov, A., Jakobsson, B., Johansson, H. T., Jonson, B., Kalantar-Nayestanaki, N., Kanungo, R., Kelic-Heil, A., Knöbel, R., Kröll, T., Krücken, R., Kurcewicz, J., Kurz, N., Labiche, M., Langer, C., Bleis, T. Le, Lemmon, R., Lepyoshkina, O., Lindberg, S., Machado, J., Marganiec, J., Martínez-Pinedo, G., Maroussov, V., Mostazo, M., Movsesyan, A., Najafi, A., Neff, T., Nilsson, T., Nociforo, C., Panin, V., Paschalis, S., Perea, A., Petri, M., Pietri, S., Plag, R., Prochazka, A., Rahaman, A., Rastrepina, G., Reifarth, R., Ribeiro, G., Ricciardi, M. V., Rigollet, C., Riisager, K., Röder, M., Rossi, D., del Rio, J. Sanchez, Savran, D., Scheit, H., Simon, H., Sorlin, O., Stoica, V., Streicher, B., Taylor, J. T., Tengblad, O., Terashima, S., Thies, R., Togano, Y., Uberseder, E., Van de Walle, J., Velho, P., Volkov, V., Wagner, A., Wamers, F., Weick, H., Weigand, M., Wheldon, C., Wilson, G., Wimmer, C., Winfield, J. S., Woods, P., Yakorev, D., Zhukov, M. V., Zilges, A., and Zuber, K.

Subjects
Nuclear Experiment, Astrophysics - Solar and Stellar Astrophysics
Abstract

With the R$^{3}$B-LAND setup at GSI we have measured exclusive relative-energy spectra of the Coulomb dissociation of $^{18}$C at a projectile energy around 425~AMeV on a lead target, which are needed to determine the radiative neutron-capture cross sections of $^{17}$C into the ground state of $^{18}$C. Those data have been used to constrain theoretical calculations for transitions populating excited states in $^{18}$C. This allowed to derive the astrophysical cross section $\sigma^{*}_{\mathrm{n}\gamma}$ accounting for the thermal population of $^{17}$C target states in astrophysical scenarios. The experimentally verified capture rate is significantly lower than those of previously obtained Hauser-Feshbach estimations at temperatures $T_{9}\leq{}1$~GK. Network simulations with updated neutron-capture rates and hydrodynamics according to the neutrino-driven wind model as well as the neutron-star merger scenario reveal no pronounced influence of neutron capture of $^{17}$C on the production of second- and third-peak elements in contrast to earlier sensitivity studies.

Published
2016
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4. Systematic investigation of projectile fragmentation using beams of unstable B and C isotopes

Author

Thies, R., Heinz, A., Adachi, T., Aksyutina, Y., Alcantara-Núñes, J., Altstadt, S., Alvarez-Pol, H., Ashwood, N., Aumann, T., Avdeichikov, V., Barr, M., Beceiro-Novo, S., Bemmerer, D., Benlliure, J., Bertulani, C. A., Boretzky, K., Borge, M. J. G., Burgunder, G., Caamano, M., Caesar, C., Casarejos, E., Catford, W., Cederkäll, J., Chakraborty, S., Chartier, M., Chulkov, L. V., Cortina-Gil, D., Crespo, R., Datta, U., Fernández, P. Díaz, Dillmann, I., Elekes, Z., Enders, J., Ershova, O., Estradé, A., Farinon, F., Fraile, L. M., Freer, M., Freudenberger, M., Fynbo, H. O. U., Galaviz, D., Geissel, H., Gernhäuser, R., Göbel, K., Golubev, P., Diaz, D. Gonzalez, Hagdahl, J., Heftrich, T., Heil, M., Heine, M., Henriques, A., Holl, M., Ickert, G., Ignatov, A., Jakobsson, B., Johansson, H. T., Jonson, B., Kalantar-Nayestanaki, N., Kanungo, R., Knöbel, R., Kröll, T., Krücken, R., Kurcewicz, J., Kurz, N., Labiche, M., Langer, C., Bleis, T. Le, Lemmon, R., Lepyoshkina, O., Lindberg, S., Machado, J., Marganiec, J., Maroussov, V., Mostazo, M., Movsesyan, A., Najafi, A., Nilsson, T., Nociforo, C., Panin, V., Paschalis, S., Perea, A., Petri, M., Pietri, S., Plag, R., Prochazka, A., Rahaman, A., Rastrepina, G., Reifarth, R., Ribeiro, G., Ricciardi, M. V., Rigollet, C., Riisager, K., Röder, M., Rossi, D., del Rio, J. Sanchez, Savran, D., Scheit, H., Simon, H., Sorlin, O., Stoica, V., Streicher, B., Taylor, J. T., Tengblad, O., Terashima, S., Togano, Y., Uberseder, E., Van de Walle, J., Velho, P., Volkov, V., Wagner, A., Wamers, F., Weick, H., Weigand, M., Wheldon, C., Wilson, G., Wimmer, C., Winfield, J. S., Woods, P., Yakorev, D., Zhukov, M. V., Zilges, A., and Zuber, K.

Subjects
Nuclear Experiment
Abstract

Background: Models describing nuclear fragmentation and fragmentation-fission deliver important input for planning nuclear physics experiments and future radioactive ion beam facilities. These models are usually benchmarked against data from stable beam experiments. In the future, two-step fragmentation reactions with exotic nuclei as stepping stones are a promising tool to reach the most neutron-rich nuclei, creating a need for models to describe also these reactions. Purpose: We want to extend the presently available data on fragmentation reactions towards the light exotic region on the nuclear chart. Furthermore, we want to improve the understanding of projectile fragmentation especially for unstable isotopes. Method: We have measured projectile fragments from 10,12-18C and 10-15B isotopes colliding with a carbon target. These measurements were all performed within one experiment, which gives rise to a very consistent dataset. We compare our data to model calculations. Results: One-proton removal cross sections with different final neutron numbers (1pxn) for relativistic 10,12-18C and 10-15B isotopes impinging on a carbon target. Comparing model calculations to the data, we find that EPAX is not able to describe the data satisfactorily. Using ABRABLA07 on the other hand, we find that the average excitation energy per abraded nucleon needs to be decreased from 27 MeV to 8.1 MeV. With that decrease ABRABLA07 describes the data surprisingly well. Conclusions: Extending the available data towards light unstable nuclei with a consistent set of new data have allowed for a systematic investigation of the role of the excitation energy induced in projectile fragmentation. Most striking is the apparent mass dependence of the average excitation energy per abraded nucleon. Nevertheless, this parameter, which has been related to final-state interactions, requires further study.

Published
2016
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5. Beyond the Neutron Drip-Line: The Unbound Oxygen Isotopes 25O and 26O

Author

Caesar, C., Simonis, J., Adachi, T., Aksyutina, Y., Alcantara, J., Altstadt, S., Alvarez-Pol, H., Ashwood, N., Aumann, T., Avdeichikov, V., Barr, M., Beceiro, S., Bemmerer, D., Benlliure, J., Bertulani, C. A., Boretzky, K., Borge, M. J. G., Burgunder, G., Caamano, M., Casarejos, E., Catford, W., Cederkäll, J., Chakraborty, S., Chartier, M., Chulkov, L., Cortina-Gil, D., Pramanik, U. Datta, Fernandez, P. Diaz, Dillmann, I., Elekes, Z., Enders, J., Ershova, O., Estrade, A., Farinon, F., Fraile, L. M., Freer, M., Freudenberger, M., Fynbo, H. O. U., Galaviz, D., Geissel, H., Gernhäuser, R., Golubev, P., Diaz, D. Gonzalez, Hagdahl, J., Heftrich, T., Heil, M., Heine, M., Heinz, A., Henriques, A., Holl, M., Holt, J. D., Ickert, G., Ignatov, A., Jakobsson, B., Johansson, H. T., Jonson, B., Kalantar-Nayestanaki, N., Kanungo, R., Kelic-Heil, A., Knöbel, R., Kröll, T., Krücken, R., Kurcewicz, J., Labiche, M., Langer, C., Bleis, T. Le, Lemmon, R., Lepyoshkina, O., Lindberg, S., Machado, J., Marganiec, J., Maroussov, V., Menéndez, J., Mostazo, M., Movsesyan, A., Najafi, A., Nilsson, T., Nociforo, C., Panin, V., Perea, A., Pietri, S., Plag, R., Prochazka, A., Rahaman, A., Rastrepina, G., Reifarth, R., Ribeiro, G., Ricciardi, M. V., Rigollet, C., Riisager, K., Röder, M., Rossi, D. M., del Rio, J. Sanchez, Savran, D., Scheit, H., Schwenk, A., Simon, H., Sorlin, O., Stoica, V., Streicher, B., Taylor, J., Tengblad, O., Terashima, S., Thies, R., Togano, Y., Uberseder, E., Van de Walle, J., Velho, P., Volkov, V., Wagner, A., Wamers, F., Weick, H., Weigand, M., Wheldon, C., Wilson, G., Wimmer, C., Winfield, J. S., Woods, P., Yakorev, D., Zhukov, M. V., Zilges, A., Zoric, M., Zuber, K., and collaboration, R3B

Subjects
Nuclear Experiment, Nuclear Theory
Abstract

The very neutron-rich oxygen isotopes 25O and 26O are investigated experimentally and theoret- ically. In this first R3B-LAND experiment, the unbound states are populated at GSI via proton- knockout reactions from 26F and 27F at relativistic energies around 450 MeV/nucleon. From the kinematically complete measurement of the decay into 24O plus one or two neutrons, the 25O ground- state energy and lifetime are determined, and upper limits for the 26O ground state are extracted. In addition, the results provide evidence for an excited state in 26O at around 4 MeV. The ex- perimental findings are compared to theoretical shell-model calculations based on chiral two- and three-nucleon (3N) forces, including for the first time residual 3N forces, which are shown to be amplified as valence neutrons are added.

Published
2012
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6. 13,14B(n, γ) via Coulomb Dissociation for Nucleosynthesis towards the r-Process

Author

Altstadt, S.G., Adachi, T., Aksyutina, Y., Alcantara, J., Alvarez-Pol, H., Ashwood, N., Atar, L., Aumann, T., Avdeichikov, V., Barr, M., Beceiro, S., Bemmerer, D., Benlliure, J., Bertulani, C.A., Boretzky, K., Borge, M.J.G., Burgunder, G., Caamano, M., Caesar, C., Casarejos, E., Catford, W., Cederkäll, J., Chakraborty, S., Chartier, M., Chulkov, L., Cortina-Gil, D., Datta Pramanik, U., Diaz Fernandez, P., Dillmann, I., Elekes, Z., Enders, J., Ershova, O., Estrade, A., Farinon, F., Fraile, L.M., Freer, M., Freudenberger, M., Fynbo, H.O.U., Galaviz, D., Geissel, H., Gernhäuser, R., Göbel, K., Golubev, P., Gonzalez Diaz, D., Hagdahl, J., Heftrich, T., Heil, M., Heine, M., Heinz, A., Henriques, A., Holl, M., Holt, J.D., Ickert, G., Ignatov, A., Jakobsson, B., Johansson, H.T., Jonson, B., Kalantar-Nayestanaki, N., Kanungo, R., Kelic-Heil, A., Knöbel, R., Kröll, T., Krücken, R., Kurcewicz, J., Kurz, N., Labiche, M., Langer, C., Le Bleis, T., Lemmon, R., Lepyoshkina, O., Machado, J., Marganiec, J., Maroussov, V., Menéndez, J., Mostazo, M., Movsesyan, A., Najafi, M.A., Nilsson, T., Nociforo, C., Panin, V., Perea, A., Pietri, S., Plag, R., Prochazka, A., Rahaman, A., Rastrepina, G., Reifarth, R., Ribeiro, G., Ricciardi, M.V., Rigollet, C., Riisager, K., Röder, M., Rossi, D., Sanchez del Rio, J., Savran, D., Scheit, H., Schwenk, A., Simon, H., Simonis, J., Sonnabend, K., Sorlin, O., Stoica, V., Streicher, B., Taylor, J., Tengblad, O., Terashima, S., Thies, R., Togano, Y., Uberseder, E., Van de Walle, J., Velho, P., Volkov, V., Wagner, A., Wamers, F., Weick, H., Weigand, M., Wheldon, C., Wilson, G., Wimmer, C., Winfield, J.S., Woods, P., Yakorev, D., Zhukov, M.V., Zilges, A., Zoric, M., and Zuber, K.

Published
2014
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12. Recent developments for an active UF6 gas target for photon-induced fission experiments

Author

Freudenberger M., Eckardt C., Enders J., Göök A., von Neumann-Cosel P., Oberstedt A., and Oberstedt S.

Subjects
Physics, QC1-999
Abstract

Recent developments for an active uranium-hexafluoride-loaded gas target as well as results on the detector gas properties are presented. The gas of choice is a mixture of argon with small amounts of UF6. This contribution presents the experimental setup and focusses on the electron drift velocity with increasing UF6 content. A time-dependent decrease in electron drift velocity is observed in our setup.

Published
2013
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13. Determination of the neutron-capture rate of C-17 for r-process nucleosynthesis

Author

Heine, M, Typel, S, Wu, M-R, Adachi, T, Aksyutina, Y, Alcantara, J, Altstadt, S, Alvarez-Pol, H, Ashwood, N, Atar, L, Aumann, T, Avdeichikov, V, Barr, M, Beceiro-Novo, S, Bemmerer, D, Benlliure, J, Bertulani, CA, Boretzky, K, Borge, MJG, Burgunder, G, Caamano, M, Caesar, C, Casarejos, E, Catford, W, Cederkaell, J, Chakraborty, S, Chartier, M, Chulkov, LV, Cortina-Gil, D, Crespo, R, Pramanik, U Datta, Fernandez, P Diaz, Dillmann, I, Elekes, Z, Enders, J, Ershova, O, Estrade, A, Farinon, F, Fraile, LM, Freer, M, Freudenberger, M, Fynbo, HOU, Galaviz, D, Geissel, H, Gernhaeuser, R, Goebel, K, Golubev, P, Diaz, D Gonzalez, Hagdahl, J, Heftrich, T, Heil, M, Heinz, A, Henriques, A, Holl, M, Ickert, G, Ignatov, A, Jakobsson, B, Johansson, HT, Jonson, B, Kalantar-Nayestanaki, N, Kanungo, R, Kelic-Heil, A, Knoebel, R, Kroell, T, Kruecken, R, Kurcewicz, J, Kurz, N, Labiche, M, Langer, C, Le Bleis, T, Lemmon, R, Lepyoshkina, O, Lindberg, S, Machado, J, Marganiec, J, Martinez-Pinedo, G, Maroussov, V, Mostazo, M, Movsesyan, A, Najafi, A, Neff, T, Nilsson, T, Nociforo, C, Panin, V, Paschalis, S, Perea, A, Petri, M, Pietri, S, Plag, R, Prochazka, A, Rahaman, A, Rastrepina, G, Reifarth, R, Ribeiro, G, Ricciardi, MV, Rigollet, C, Riisager, K, Roeder, M, Rossi, D, del Rio, J Sanchez, Savran, D, Scheit, H, Simon, H, Sorlin, O, Stoica, V, Streicher, B, Taylor, JT, Tengblad, O, Terashima, S, Thies, R, Togano, Y, Uberseder, E, Van de Walle, J, Velho, P, Volkov, V, Wagner, A, Wamers, F, Weick, H, Weigand, M, Wheldon, C, Wilson, G, Wimmer, C, Winfield, JS, Woods, P, Yakorev, D, Zhukov, MV, Zilges, A, Zuber, K, and Collaboration, R3B

Published
2017

14. Determination of the neutron-capture rate of C-17 for r-process nucleosynthesis

Author

Heine, M., Typel, S., Wu, M. -R., Adachi, T., Aksyutina, Y., Alcantara, J., Altstadt, S., Álvarez-Pol, H., Ashwood, N., Atar, L., Aumann, T., Avdeichikov, V., Barr, M., Beceiro-Novo, S., Bemmerer, D., Benlliure, J., Bertulani, C.A, Boretzky, K., Borge, M. J. G., Burgunder, G., Caamano, M., Caesar, C., Casarejos, E., Catford, W., Cederkaell, J., Chakraborty, S., Chartier, M., Chulkov, L. V., Cortina-Gil, D., Crespo, Raquel, Pramanik, U. Datta, Fernandez, P. Diaz, Dillmann, I., Elekes, Z., Enders, J., Ershova, O., Estrade, A., Farinon, F., Fraile, L. M., Freer, M., Freudenberger, M., Fynbo, H. O. U., Galaviz, D., Geissel, H., Gernhaeuser, R., Göbel, K., Golubev, P., Diaz, D. Gonzalez, Hagdahl, J., and Riisager, K.

Subjects
EJECTA, LIGHT, ELEMENTS, NUCLEAR-PHYSICS, DISSOCIATION, Nuclear Experiment, METAL-POOR, RICH, DETECTOR, RELATIVISTIC HEAVY-IONS, COSMOCHRONOLOGY
Abstract

With the (RB)-B-3-LAND setup at GSI we have measured exclusive relative-energy spectra of the Coulomb dissociation of C-18 at a projectile energy around 425A MeV on a lead target, which are needed to determine the radiative neutron-capture cross sections of C-17 into the ground state of C-18. Those data have been used to constrain theoretical calculations for transitions populating excited states in C-18. This allowed to derive the astrophysical cross section sigma(n gamma)*. accounting for the thermal population of C-17 target states in astrophysical scenarios. The experimentally verified capture rate is significantly lower than those of previously obtained Hauser-Feshbach estimations at temperatures T-9

Published
2017
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15. Determination of the Neutron-Capture Rate of $^{17}$C for the R-process Nucleosynthesis

Author

Heine, M., Typel, S., Wu, M. -R, Adachi, T., Aksyutina, Y., Alcantara, J., Altstadt, S., Alvarez-Pol, H., Ashwood, N., Aumann, T., Avdeichikov, V., Barr, M., Beceiro-Novo, S., Daniel Bemmerer, Benlliure, J., Bertulani, C. A., Boretzky, K., Borge, M. J. G., Burgunder, G., Caamano, M., Caesar, C., Casarejos, E., Catford, W., Cederkäll, J., Chakraborty, S., Chartier, M., Chulkov, L. V., Cortina-Gil, D., Crespo, R., Datta Pramanik, U., Diaz Fernandez, P., Dillmann, I., Elekes, Z., Enders, J., Ershova, O., Estrade, A., Farinon, F., Fraile, L. M., Freer, M., Freudenberger, M., Fynbo, H. O. U., Galaviz, D., Geissel, H., Gernhäuser, R., Göbel, K., Golubev, P., Gonzalez Diaz, D., Hagdahl, J., Heftrich, T., Heil, M., Heinz, A., Henriques, A., Holl, M., Ickert, G., Ignatov, A., Jakobsson, B., Johansson, H. T., Jonson, B., Kalantar-Nayestanaki, N., Kanungo, R., Kelic-Heil, A., Knöbel, R., Kröll, T., Krücken, R., Kurcewicz, J., Kurz, N., Labiche, M., Langer, C., Le Bleis, T., Lemmon, R., Lepyoshkina, O., Lindberg, S., Machado, J., Marganiec, J., Martínez-Pinedo, G., Maroussov, V., Mostazo, M., Movsesyan, A., Najafi, A., Neff, T., Nilsson, T., Nociforo, C., Panin, V., Paschalis, S., Perea, A., Petri, M., Pietri, S., Plag, R., Prochazka, A., Rahaman, A., Rastrepina, G., Reifarth, R., Ribeiro, G., Ricciardi, M. V., Rigollet, C., Riisager, K., Röder, M., Rossi, D., Sanchez Del Rio, J., Savran, D., Scheit, H., Simon, H., Sorlin, O., Stoica, V., Streicher, B., Taylor, J. T., Tengblad, O., Terashima, S., Thies, R., Togano, Y., Uberseder, E., Walle, J., Velho, P., Volkov, V., Wagner, A., Wamers, F., Weick, H., Weigand, M., Wheldon, C., Wilson, G., Wimmer, C., Winfield, J. S., Woods, P., Yakorev, D., Zhukov, M. V., Zilges, A., Zuber, K., Helmholtz zentrum für Schwerionenforschung GmbH (GSI), KVI-CART, University of Groningen, University of Groningen [Groningen], Grand Accélérateur National d'Ions Lourds (GANIL), Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), R3B Collaboration, Research unit Nuclear & Hadron Physics, and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
astro-ph.SR, Astrophysics - Solar and Stellar Astrophysics, FOS: Physical sciences, Nuclear Experiment (nucl-ex), [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], nucl-ex, Nuclear Experiment, Solar and Stellar Astrophysics (astro-ph.SR)
Abstract

International audience; With the R$^{3}$B-LAND setup at GSI we have measured exclusive relative-energy spectra of the Coulomb dissociation of $^{18}$C at a projectile energy around 425~AMeV on a lead target, which are needed to determine the radiative neutron-capture cross sections of $^{17}$C into the ground state of $^{18}$C. Those data have been used to constrain theoretical calculations for transitions populating excited states in $^{18}$C. This allowed to derive the astrophysical cross section $\sigma^{*}_{\mathrm{n}\gamma}$ accounting for the thermal population of $^{17}$C target states in astrophysical scenarios. The experimentally verified capture rate is significantly lower than those of previously obtained Hauser-Feshbach estimations at temperatures $T_{9}\leq{}1$~GK. Network simulations with updated neutron-capture rates and hydrodynamics according to the neutrino-driven wind model as well as the neutron-star merger scenario reveal no pronounced influence of neutron capture of $^{17}$C on the production of second- and third-peak elements in contrast to earlier sensitivity studies.

Published
2017
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16. Correlated mass, energy, and angular distributions from bremsstrahlung-induced fission of U 234 and Th 232 in the energy region of the fission barrier

Author

Göök, A., Eckardt, C., Enders, J., Freudenberger, M., Oberstedt, A., Oberstedt, S., Göök, A., Eckardt, C., Enders, J., Freudenberger, M., Oberstedt, A., and Oberstedt, S.

Abstract

The bremstrahlung-induced fission of U234 and Th232 has been studied at the superconducting Darmstadt linear accelerator (S-DALINAC) in the excitation energy region close to the fission barrier. Fission-fragment mass and total kinetic energy (TKE) distributions from U234 were studied for the first time in this energy region. The results have been analysed in terms of fission modes, and a dominant yield of the mass-asymmetric standard-2 mode was found in both nuclei. No strong dependence of the fission-mode weights on the excitation energy of the compound nucleus was found. Correlations among mass, TKE, and angular distributions have also been investigated. A correlation in the form of an increased anisotropy for far-asymmetric masses and low TKE were found in both fissioning systems. A possible interpretation of this correlation in terms of fission modes is discussed., QC 20240110

Published
2017
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17. Coulomb dissociation of N-20,N-21

Author

Roeder, Marko, Adachi, Tatsuya, Aksyutina, Yulia, Alcantara, Juan, Altstadt, Sebastian, Alvarez-Pol, Hector, Ashwood, Nicholas, Atar, Leyla, Aumann, Thomas, Avdeichikov, Vladimir, Barr, M., Beceiro, Saul, Bemmerer, Daniel, Benlliure, Jose, Bertulani, Carlos, Boretzky, Konstanze, Borge, Maria J. G., Burgunder, G., Caamano, Manuel, Caesar, Christoph, Casarejos, Enrique, Catford, Wilton, Cederkall, Joakim, Chakraborty, S., Chartier, Marielle, Chulkov, Leonid, Cortina-Gil, Dolores, Crespo, Raquel, Pramanik, Ushasi Datta, Diaz-Fernandez, Paloma, Dillmann, Iris, Elekes, Zoltan, Enders, Joachim, Ershova, Olga, Estrade, A., Farinon, F., Fraile, Luis M., Freer, Martin, Freudenberger, M., Fynbo, Hans, Galaviz, Daniel, Geissel, Hans, Gernhaeuser, Roman, Goebel, Kathrin, Kalantar-Nayestanaki, Nasser, Najafi, Mohammad Ali, Rigollet, Catherine, Stoica, V., Streicher, Branislav, Van de Walle, J., and Research unit Nuclear & Hadron Physics

Subjects
LIGHT, REFERENCES, NUCLEI, Astrophysics::High Energy Astrophysical Phenomena, ELEMENTS, R-PROCESS NUCLEOSYNTHESIS, DETECTOR, RELATIVISTIC HEAVY-IONS, STARS, GRAPHS, TABLES
Abstract

Neutron-rich light nuclei and their reactions play an important role in the creation of chemical elements. Here, data from a Coulomb dissociation experiment on N-20,N-21 are reported. Relativistic N-20,N-21 ions impinged on a lead target and the Coulomb dissociation cross section was determined in a kinematically complete experiment. Using the detailed balance theorem, the N-19(n,gamma)N-20 and N-20(n,gamma)N-21 excitation functions and thermonuclear reaction rates have been determined. The N-19(n,gamma)N-20 rate is up to a factor of 5 higher at T

Published
2016

18. Systematic investigation of projectile fragmentation using beams of unstable B and C isotopes

Author

Thies, R, Heinz, A, Adachi, T, Aksyutina, Y, Alcantara-Nunes, J, Altstadt, S, Alvarez-Pol, H, Ashwood, N, Aumann, T, Avdeichikov, V, Barr, M, Beceiro-Novo, S, Bemmerer, D, Benlliure, J, Bertulani, CA, Boretzky, K, Borge, MJG, Burgunder, G, Camano, M, Caesar, C, Casarejos, E, Catford, W, Cederkall, J, Chakraborty, S, Chartier, M, Chulkov, LV, Cortina-Gil, D, Crespo, R, Datta, U, Diaz Fernandez, P, Dillmann, I, Elekes, Z, Enders, J, Ershova, O, Estrade, A, Farinon, F, Fraile, LM, Freer, M, Freudenberger, M, Fynbo, HOU, Galaviz, D, Geissel, H, Gernhauser, R, Gobel, K, Golubev, P, Diaz, DG, Hagdahl, J, Heftrich, T, Heil, M, Heine, M, Henriques, A, Holl, M, Ickert, G, Ignatov, A, Jakobsson, B, Johansson, HT, Jonson, B, Kalantar-Nayestanaki, N, Kanungo, R, Knobel, R, Kroll, T, Krucken, R, Kurcewicz, J, Kurz, N, Labiche, M, Langer, C, Le Bleis, T, Lemmon, R, Lepyoshkina, O, Lindberg, S, Machado, J, Marganiec, J, Maroussov, V, Mostazo, M, Movsesyan, A, Najafi, A, Nilsson, T, Nociforo, C, Panin, V, Paschalis, S, Perea, A, Petri, M, Pietri, S, Plag, R, Prochazka, A, Rahaman, A, Rastrepina, G, Reifarth, R, Ribeiro, G, Ricciardi, MV, Rigollet, C, Riisager, K, Roder, M, Rossi, D, Sanchez del Rio, J, Savran, D, Scheit, H, Simon, H, Sorlin, O, Stoica, V, Streicher, B, Taylor, JT, Tengblad, O, Terashima, S, Togano, Y, Uberseder, E, Van de Walle, J, Velho, P, Volkov, V, Wagner, A, Wamers, F, Weick, H, Weigand, M, Wheldon, C, Wilson, G, Wimmer, C, Winfield, JS, Woods, P, Yakorev, D, Zhukov, MV, Zilges, A, Zuber, K, Collaboration, R, Helmholtz zentrum für Schwerionenforschung GmbH (GSI), Grand Accélérateur National d'Ions Lourds (GANIL), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), R3B Collaboration, KVI - Center for Advanced Radiation Technology, Research unit Nuclear & Hadron Physics, Federal Ministry of Education and Research (Germany), Nuclear Astrophysics Virtual Institute (Germany), Helmholtz Association, Science and Technology Facilities Council (UK), Department of Energy (US), Ministerio de Economía y Competitividad (España), Swedish Research Council, Helmholtz Centre for Heavy Ion Research, National Science Foundation (US), and Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)

Subjects
Physics, Ion beam, 010308 nuclear & particles physics, Fission, Projectile, Nuclear Theory, Fragmentation (computing), Aucun, FOS: Physical sciences, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 01 natural sciences, Nuclear physics, nuclear fragmentation fission radioactive ion beam facilities C10 C12−18 B10−15 isotope, 0103 physical sciences, Neutron, Física nuclear, Nuclear Experiment (nucl-ex), 010306 general physics, Nucleon, Nuclear Experiment, Excitation, Beam (structure)
Abstract

R. Thies et al.; 9 pags., 7 figs., 1 tab., Background: Models describing nuclear fragmentation and fragmentation fission deliver important input for planning nuclear physics experiments and future radioactive ion beam facilities. These models are usually benchmarked against data from stable beam experiments. In the future, two-step fragmentation reactions with exotic nuclei as stepping stones are a promising tool for reaching the most neutron-rich nuclei, creating a need for models to describe also these reactions. Purpose: We want to extend the presently available data on fragmentation reactions towards the light exotic region on the nuclear chart. Furthermore, we want to improve the understanding of projectile fragmentation especially for unstable isotopes. Method: We have measured projectile fragments from C10,12-18 and B10-15 isotopes colliding with a carbon target. These measurements were all performed within one experiment, which gives rise to a very consistent data set. We compare our data to model calculations. Results: One-proton removal cross sections with different final neutron numbers (1pxn) for relativistic C10,12-18 and B10-15 isotopes impinging on a carbon target. Comparing model calculations to the data, we find that the epax code is not able to describe the data satisfactorily. Using abrabla07 on the other hand, we find that the average excitation energy per abraded nucleon needs to be decreased from 27 MeV to 8.1 MeV. With that decrease abrabla07 describes the data surprisingly well. Conclusions: Extending the available data towards light unstable nuclei with a consistent set of new data has allowed a systematic investigation of the role of the excitation energy induced in projectile fragmentation. Most striking is the apparent mass dependence of the average excitation energy per abraded nucleon. Nevertheless, this parameter, which has been related to final-state interactions, requires further study. ©2016 American Physical Society, We thank the FRS and the GSI accelerator staff for their efforts. This work was supported by the Swedish Research Council. O.T. was supported by the Spanish Research Council under project FPA2012-32443, C.A.B. acknowledges support from the U.S. DOE Grant No. DE-FG02-08ER41533 and the U.S. NSF Grant No. 1415656. L.M.F. acknowledges support by the Spanish Research Council under project FPA2013-41267-P and M.R. was supported by GSI (F&E, DR-ZUBE), German BMBF (06DR134I and 05P09CRFN5), the Nuclear Astrophysics Virtual Institute (NAVI, HGF VHVI- 417) and the Helmholtz Association Detector Technology and Systems Platform. T.K. acknowledges support by the German BMBF No. 06DA9040I, No. 05P12RDFN8, and No. 05P15RDFN1. C.W. acknowledges funding by the UK STFC No. ST/E500651/1, while N.A. and M.F. acknowledge funding by the UK STFC No. ST/F011989/1.

Published
2016
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20. Coulomb dissociation of N-20,N-21

Author

Röder, M., Adachi, T., Aksyutina, Y., Alcantara, J., Altstadt, S., Alvarez-Pol, H., Ashwood, N., Atar, L., Aumann, T., Avdeichikov, V., Barr, M., Beceiro, S., Bemmerer, D., Benlliure, J., Bertulani, C., Boretzky, K., Borge, M., Burgunder, G., Caamano, M., Caesar, C., Casarejos, E., Catford, W., Cederkall, J., Chakraborty, S., Chartier, M., Chulkov, L., Cortina-Gil, D., Crespo, R., Pramanik, U., Diaz-Fernandez, P., Dillmann, I., Elekes, Z., Enders, J., Ershova, O., Estrade, A., Farinon, F., Fraile, L., Freer, M., Freudenberger, M., Fynbo, H., Galaviz, D., Geissel, H., Gernhauser, R., Gobel, K., Golubev, P., Diaz, D., Hagdahl, J., Heftrich, T., Heil, M., Heine, M., Heinz, A., Henriques, A., Holl, M., Ickert, G., Ignatov, A., Jakobsson, B., Johansson, H., Jonson, B., Kalantar-Nayestanaki, N., Kanungo, R., Kelic-Heil, A., Knobel, R., Kroll, T., Krucken, R., Kurcewicz, J., Kurz, N., Labiche, M., Langer, C., Le Bleis, T., Lemmon, R., Lepyoshkina, O., Lindberg, S., Machado, J., Marganiec, J., Caro, M., Movsesyan, A., Najafi, M., Nilsson, T., Nociforo, C., Panin, V., Paschalis, S., Perea, A., Petri, M., Pietri, S., Plag, R., Prochazka, A., Rahaman, M., Rastrepina, G., Reifarth, R., Ribeiro, G., Ricciardi, M., Rigollet, C., Riisager, K., Rossi, D., Saez, J., Savran, D., Scheit, H., Simon, H., Sorlin, O., Stoica, V., Streicher, B., Taylor, J., Tengblad, O., Terashima, S., Thies, R., Togano, Y., Uberseder, E., Walle, J., Velho, P., Volkov, V., Wagner, A., Wamers, F., Weick, H., Weigand, M., Wheldon, C., Wilson, G., Wimmer, C., Winfield, J., Woods, P., Yakorev, D., Zhukov, M., Zilges, A., Zuber, K., Röder, M., Adachi, T., Aksyutina, Y., Alcantara, J., Altstadt, S., Alvarez-Pol, H., Ashwood, N., Atar, L., Aumann, T., Avdeichikov, V., Barr, M., Beceiro, S., Bemmerer, D., Benlliure, J., Bertulani, C., Boretzky, K., Borge, M., Burgunder, G., Caamano, M., Caesar, C., Casarejos, E., Catford, W., Cederkall, J., Chakraborty, S., Chartier, M., Chulkov, L., Cortina-Gil, D., Crespo, R., Pramanik, U., Diaz-Fernandez, P., Dillmann, I., Elekes, Z., Enders, J., Ershova, O., Estrade, A., Farinon, F., Fraile, L., Freer, M., Freudenberger, M., Fynbo, H., Galaviz, D., Geissel, H., Gernhauser, R., Gobel, K., Golubev, P., Diaz, D., Hagdahl, J., Heftrich, T., Heil, M., Heine, M., Heinz, A., Henriques, A., Holl, M., Ickert, G., Ignatov, A., Jakobsson, B., Johansson, H., Jonson, B., Kalantar-Nayestanaki, N., Kanungo, R., Kelic-Heil, A., Knobel, R., Kroll, T., Krucken, R., Kurcewicz, J., Kurz, N., Labiche, M., Langer, C., Le Bleis, T., Lemmon, R., Lepyoshkina, O., Lindberg, S., Machado, J., Marganiec, J., Caro, M., Movsesyan, A., Najafi, M., Nilsson, T., Nociforo, C., Panin, V., Paschalis, S., Perea, A., Petri, M., Pietri, S., Plag, R., Prochazka, A., Rahaman, M., Rastrepina, G., Reifarth, R., Ribeiro, G., Ricciardi, M., Rigollet, C., Riisager, K., Rossi, D., Saez, J., Savran, D., Scheit, H., Simon, H., Sorlin, O., Stoica, V., Streicher, B., Taylor, J., Tengblad, O., Terashima, S., Thies, R., Togano, Y., Uberseder, E., Walle, J., Velho, P., Volkov, V., Wagner, A., Wamers, F., Weick, H., Weigand, M., Wheldon, C., Wilson, G., Wimmer, C., Winfield, J., Woods, P., Yakorev, D., Zhukov, M., Zilges, A., and Zuber, K.

Abstract

Neutron-rich light nuclei and their reactions play an important role in the creation of chemical elements. Here, data from a Coulomb dissociation experiment on N-20,N-21 are reported. Relativistic N-20,N-21 ions impinged on a lead target and the Coulomb dissociation cross section was determined in a kinematically complete experiment. Using the detailed balance theorem, the N-19(n,gamma)N-20 and N-20(n,gamma)N-21 excitation functions and thermonuclear reaction rates have been determined. The N-19(n,gamma)N-20 rate is up to a factor of 5 higher at T < 1 GK with respect to previous theoretical calculations, leading to a 10% decrease in the predicted fluorine abundance.

Published
2016

21. B-13,B-14(n,gamma) via Coulomb Dissociation for Nucleosynthesis towards the r-Process

Author

Altstadt, S. G., Adachi, T., Aksyutina, Y., Alcantara, J., Alvarez-Pol, H., Ashwood, N., Atar, L., Aumann, T., Avdeichikov, V., Barr, M., Beceiro, S., Bemmerer, D., Benlliure, J., Bertulani, C. A., Boretzky, K., Borge, M. J. G., Burgunder, G., Caamano, M., Caesar, C., Casarejos, E., Catford, W., Cederkall, J., Chakraborty, S., Chartier, M., Chulkov, L., Cortina-Gil, D., Pramanik, U. Datta, Fernandez, P. Diaz, Dillmann, I., Elekes, Z., Enders, J., Ershova, O., Estrade, A., Farinon, F., Fraile, L. M., Freer, M., Freudenberger, M., Fynbo, H. O. U., Galaviz, D., Geissel, H., Gernhaeuser, R., Goebel, K., Golubev, P., Gonzalez Diaz, D., Kalantar-Nayestanaki, N., Najafi, M. A., Rigollet, C., Stoica, V., Streicher, B., Van de Walle, J., and Research unit Nuclear & Hadron Physics

Subjects
LIGHT
Abstract

Radioactive beams of B-14,B-15 produced by fragmentation of a primary Ar-40 beam were directed onto a Pb target to investigate the neutron breakup within the Coulomb field. The experiment was performed at the LAND/(RB)-B-3 setup. Preliminary results for the Coulomb dissociation cross sections as well as for the astrophysically interesting inverse reactions, B-13,B-14(n,gamma), are presented.

Published
2014

22. Beyond the neutron drip line: The unbound oxygen isotopes O-25 and O-26

Author

Caesar, C., Simonis, J., Adachi, T., Aksyutina, Y., Alcantara, J., Altstadt, S., Alvarez-Pol, H., Ashwood, N., Aumann, T., Avdeichikov, V., Barr, M., Beceiro, S., Bemmerer, D., Benlliure, J., Bertulani, C. A., Boretzky, K., Borge, M. J. G., Burgunder, G., Caamano, M., Casarejos, E., Catford, W., Cederkaell, J., Chakraborty, S., Chartier, M., Chulkov, L., Cortina-Gil, D., Pramanik, U. Datta, Fernandez, P. Diaz, Dillmann, I., Elekes, Z., Enders, J., Ershova, O., Estrade, A., Farinon, F., Fraile, L. M., Freer, M., Freudenberger, M., Fynbo, H. O. U., Galaviz, D., Geissel, H., Gernhaeuser, R., Golubev, P., Diaz, D. Gonzalez, Hagdahl, J., Heftrich, T., Heil, M., Kalantar-Nayestanaki, N., Rigollet, C., Streicher, B., Van de Walle, J., and KVI - Center for Advanced Radiation Technology

Subjects
Nuclear Theory, RICH NUCLEI, PARTICLE STABILITY, Nuclear Experiment, DETECTOR, RELATIVISTIC HEAVY-IONS
Abstract

The very neutron-rich oxygen isotopes O-25 and O-26 are investigated experimentally and theoretically. The unbound states are populated in an experiment performed at the R3B-LAND setup at GSI via proton-knockout reactions from F-26 and F-27 at relativistic energies around 442 and 414 MeV/nucleon, respectively. From the kinematically complete measurement of the decay into O-24 plus one or two neutrons, the O-25 ground-state energy and width are determined, and upper limits for the O-26 ground-state energy and lifetime are extracted. In addition, the results provide indications for an excited state in O-26 at around 4 MeV. The experimental findings are compared to theoretical shell-model calculations based on chiral two- and three-nucleon (3N) forces, including for the first time residual 3N forces, which are shown to be amplified as valence neutrons are added.

Published
2013

23. Beyond the neutron drip line: The unbound oxygen isotopes O and O

Author

Caesar, C., Simonis, J., Adachi, T., Aksyutina, Y., Alcantara, J., Altstadt, S., Alvarez-Pol, H., Ashwood, N., Aumann, T., Avdeichikov, V., Barr, M., Beceiro, S., Bemmerer, D., Benlliure, J., Bertulani, C. A., Boretzky, K., Borge, M. J. G., Burgunder, G., Caamano, M., Casarejos, E., Catford, W., Cederkäll, J., Chakraborty, S., Chartier, M., Chulkov, L., Cortina-Gil, D., Datta Pramanik, U., Diaz Fernandez, P., Dillmann, I., Elekes, Z., Enders, J., Ershova, O., Estrade, A., Farinon, F., Fraile, L. M., Freer, M., Freudenberger, M., Fynbo, H. O. U., Galaviz, D., Geissel, H., Gernhäuser, R., Golubev, P., Gonzalez Diaz, D., Hagdahl, J., Heftrich, T., Heil, M., Heine, M., Heinz, A., Henriques, A., Holl, M., Holt, J. D., Ickert, G., Ignatov, A., Jakobsson, B., Johansson, H. T., Jonson, B., Kalantar-Nayestanaki, N., Kanungo, R., Kelic-Heil, A., Knöbel, R., Kröll, T., Krücken, R., Kurcewicz, J., Labiche, M., Langer, C., Le Bleis, T., Lemmon, R., Lepyoshkina, O., Lindberg, S., Machado, J., Marganiec, J., Maroussov, V., Menéndez, J., Mostazo, M., Movsesyan, A., Najafi, A., Nilsson, T., Nociforo, C., Panin, V., Perea, A., Pietri, S., Plag, R., Prochazka, A., Rahaman, A., Rastrepina, G., Reifarth, R., Ribeiro, G., Ricciardi, M. V., Rigollet, C., Riisager, K., Röder, M., Rossi, D., Sanchez del Rio, J., Savran, D., Scheit, H., Schwenk, A., Simon, H., Sorlin, O., Stoica, V., Streicher, B., Taylor, J., Tengblad, O., Terashima, S., Thies, R., Togano, Y., Uberseder, E., Van de Walle, J., Velho, P., Volkov, V., Wagner, A., Wamers, F., Weick, H., Weigand, M., Wheldon, C., Wilson, G., Wimmer, C., Winfield, J. S., Woods, P., Yakorev, D., Zhukov, M. V., Zilges, A., Zoric, M., and Zuber, K.

Subjects
Aucun
Published
2013
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24. Beyond the neutron drip line: The unbound oxygen isotopes O-25 and O-26

Author

Caesar, C, Simonis, J, Adachi, T, Aksyutina, Y, Alcantara, J, Altstadt, S, Alvarez-Pol, H, Ashwood, N, Aumann, T, Avdeichikov, V, Barr, M, Beceiro, S, Bemmerer, D, Benlliure, J, Bertulani, CA, Boretzky, K, Borge, MJG, Burgunder, G, Caamano, M, Casarejos, E, Catford, W, Cederkaell, J, Chakraborty, S, Chartier, M, Chulkov, L, Cortina-Gil, D, Pramanik, UD, Fernandez, PD, Dillmann, I, Elekes, Z, Enders, J, Ershova, O, Estrade, A, Farinon, F, Fraile, LM, Freer, M, Freudenberger, M, Fynbo, HOU, Galaviz, D, Geissel, H, Gernhaeuser, R, Golubev, P, Gonzalez Diaz, D, Hagdahl, J, Heftrich, T, Heil, M, Heine, M, Heinz, A, Henriques, A, Holl, M, Holt, JD, Ickert, G, Ignatov, A, Jakobsson, B, Johansson, HT, Jonson, B, Kalantar-Nayestanaki, N, Kanungo, R, Kelic-Heil, A, Knoebel, R, Kroell, T, Kruecken, R, Kurcewicz, J, Labiche, M, Langer, C, Le Bleis, T, Lemmon, R, Lepyoshkina, O, Lindberg, S, Machado, J, Marganiec, J, Maroussov, V, Menendez, J, Mostazo, M, Movsesyan, A, Najafi, A, Nilsson, T, Nociforo, C, Panin, V, Perea, A, Pietri, S, Plag, R, Prochazka, A, Rahaman, A, Rastrepina, G, Reifarth, R, Ribeiro, G, Ricciardi, MV, Rigollet, C, Riisager, K, Roeder, M, Rossi, D, del Rio, JS, Savran, D, Scheit, H, Schwenk, A, Simon, H, Sorlin, O, Stoica, V, Streicher, B, Taylor, J, Tengblad, O, Terashima, S, Thies, R, Togano, Y, Uberseder, E, Van de Walle, J, Velho, P, Volkov, V, Wagner, A, Wamers, F, Weick, H, Weigand, M, Wheldon, C, Wilson, G, Wimmer, C, Winfield, JS, Woods, P, Yakorev, D, Zhukov, MV, Zilges, A, Zoric, M, Zuber, K, Caesar, C, Simonis, J, Adachi, T, Aksyutina, Y, Alcantara, J, Altstadt, S, Alvarez-Pol, H, Ashwood, N, Aumann, T, Avdeichikov, V, Barr, M, Beceiro, S, Bemmerer, D, Benlliure, J, Bertulani, CA, Boretzky, K, Borge, MJG, Burgunder, G, Caamano, M, Casarejos, E, Catford, W, Cederkaell, J, Chakraborty, S, Chartier, M, Chulkov, L, Cortina-Gil, D, Pramanik, UD, Fernandez, PD, Dillmann, I, Elekes, Z, Enders, J, Ershova, O, Estrade, A, Farinon, F, Fraile, LM, Freer, M, Freudenberger, M, Fynbo, HOU, Galaviz, D, Geissel, H, Gernhaeuser, R, Golubev, P, Gonzalez Diaz, D, Hagdahl, J, Heftrich, T, Heil, M, Heine, M, Heinz, A, Henriques, A, Holl, M, Holt, JD, Ickert, G, Ignatov, A, Jakobsson, B, Johansson, HT, Jonson, B, Kalantar-Nayestanaki, N, Kanungo, R, Kelic-Heil, A, Knoebel, R, Kroell, T, Kruecken, R, Kurcewicz, J, Labiche, M, Langer, C, Le Bleis, T, Lemmon, R, Lepyoshkina, O, Lindberg, S, Machado, J, Marganiec, J, Maroussov, V, Menendez, J, Mostazo, M, Movsesyan, A, Najafi, A, Nilsson, T, Nociforo, C, Panin, V, Perea, A, Pietri, S, Plag, R, Prochazka, A, Rahaman, A, Rastrepina, G, Reifarth, R, Ribeiro, G, Ricciardi, MV, Rigollet, C, Riisager, K, Roeder, M, Rossi, D, del Rio, JS, Savran, D, Scheit, H, Schwenk, A, Simon, H, Sorlin, O, Stoica, V, Streicher, B, Taylor, J, Tengblad, O, Terashima, S, Thies, R, Togano, Y, Uberseder, E, Van de Walle, J, Velho, P, Volkov, V, Wagner, A, Wamers, F, Weick, H, Weigand, M, Wheldon, C, Wilson, G, Wimmer, C, Winfield, JS, Woods, P, Yakorev, D, Zhukov, MV, Zilges, A, Zoric, M, and Zuber, K

Published
2013

25. Abstract P5-04-02: Biopsy of metastases impacts treatment choice and patient outcome in breast cancer – Final results of the WSG/DETECT PRIMET study

Author

Wuerstlein, R, primary, Kates, R, additional, Heitz, F, additional, Gluz, O, additional, Ortmann, M, additional, Freudenberger, M, additional, du Bois, A, additional, Bensmann, E, additional, Pelz, E, additional, Mallmann, P, additional, Fehm, T, additional, Nitz, U, additional, Liedtke, C, additional, and Harbeck, N, additional

Published
2013
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26. Direct reactions of light exotic beams measured in complete kinematics at R3B

Author

Adachi, T., Aksyutina, Y., Alcantara, J., Altstadt, S., Alvarez-Pol, H., Ashwood, N., Aumann, T., Barr, M., Beceiro, S., Bemmerer, D., Benlliure, J., Boretzky, K., Burgunder, G., Caamano, M., Caesar, C., Casarejos, E., Catford, W., Chakraborty, S., Chartier, M., Chulkov, L., Cortina-Gil, D., Datta Pramanik, U., Diaz, P., Dillmann, I., Enders, J., Ershova, O., Estrade, A., Farinon, F., Fraile, L. M., Freer, M., Freudenberger, M., Galaviz Redondo, D., Geissel, H., Gonzalez Diaz, D., Hagdahl, J., Heftrich, T., Heil, M., Heine, M., Henriques, A., Holl, M., Ignatov, A., Johansson, H., Jonson, B., Kalantar, N., Knöbel, R., Kroell, T., Krücken, R., Kurcewicz, J., Labiche, M., Langer, C., Le Bleis, T., Lemmon, R., Machado, J., Marganiec, J., Movsesyan, A., Najafi, A., Nilsson, T., Nociforo, C., Panin, V., Pietri, S., Plag, R., Prochazka, A., Rahaman, A., Rastrepina, G., Reifarth, R., Ribeiro, G., Ricciardi, M. V., Rigollet, C., Riisager, K., Röder, M., Rossi, D., Sanchez Del Rio, J., Savran, D., Scheit, H., Simon, H., Sorlin, O., Streicher, B., Taylor, J., Tengblad, O., Terashima, S., Thies, R., Yasuhiro, T., Uberseder, E., Walle, J., Velho, P., Volkov, V., Wagner, A., Wamers, F., Weick, H., Weigand, M., Wheldon, C., Wilson, G., Wimmer, C., Winfield, J., Woods, P., Yakorev, D., Zoric, M., Zuber, K., Adachi, T., Aksyutina, Y., Alcantara, J., Altstadt, S., Alvarez-Pol, H., Ashwood, N., Aumann, T., Barr, M., Beceiro, S., Bemmerer, D., Benlliure, J., Boretzky, K., Burgunder, G., Caamano, M., Caesar, C., Casarejos, E., Catford, W., Chakraborty, S., Chartier, M., Chulkov, L., Cortina-Gil, D., Datta Pramanik, U., Diaz, P., Dillmann, I., Enders, J., Ershova, O., Estrade, A., Farinon, F., Fraile, L. M., Freer, M., Freudenberger, M., Galaviz Redondo, D., Geissel, H., Gonzalez Diaz, D., Hagdahl, J., Heftrich, T., Heil, M., Heine, M., Henriques, A., Holl, M., Ignatov, A., Johansson, H., Jonson, B., Kalantar, N., Knöbel, R., Kroell, T., Krücken, R., Kurcewicz, J., Labiche, M., Langer, C., Le Bleis, T., Lemmon, R., Machado, J., Marganiec, J., Movsesyan, A., Najafi, A., Nilsson, T., Nociforo, C., Panin, V., Pietri, S., Plag, R., Prochazka, A., Rahaman, A., Rastrepina, G., Reifarth, R., Ribeiro, G., Ricciardi, M. V., Rigollet, C., Riisager, K., Röder, M., Rossi, D., Sanchez Del Rio, J., Savran, D., Scheit, H., Simon, H., Sorlin, O., Streicher, B., Taylor, J., Tengblad, O., Terashima, S., Thies, R., Yasuhiro, T., Uberseder, E., Walle, J., Velho, P., Volkov, V., Wagner, A., Wamers, F., Weick, H., Weigand, M., Wheldon, C., Wilson, G., Wimmer, C., Winfield, J., Woods, P., Yakorev, D., Zoric, M., and Zuber, K.

Abstract

An experiment has been performed by the R3B collaboration aiming at the investigation of light neutron-rich nuclei utilizing kinematically complete measurements of reactions at relativistic energies with the R3 B-LAND reaction setup at Cave C. The physics topics to be studied comprise the measurement of astrophysical reaction rates relevant for r-process nucleosynthesis using heavy-ion induced electromagnetic excitation and quasi-free knockout reactions to study the evolution of shell and cluster structures close to and beyond the dripline.

Published
2011

27. Persistent Triple-Negative Phenotype Is Associated with Poorest Outcome among Patients with Metastatic Breast Cancer (BC) - Results of the Retrospective Multicenter PriMet Study Comparing Molecular BC Phenotypes in Primary Tumors and Corresponding Recurrences

Author

Liedtke, C., Gluz, O., Heitz, F., Freudenberger, M., Wuestlein, R., Hungermann, D., Ortmann, M., Kates, R. E., Nitz, U., du Bois, A., Fehm, T. N., Harbeck, N., Liedtke, C., Gluz, O., Heitz, F., Freudenberger, M., Wuestlein, R., Hungermann, D., Ortmann, M., Kates, R. E., Nitz, U., du Bois, A., Fehm, T. N., and Harbeck, N.

Published
2010

29. Beyond the neutron drip line: The unbound oxygen isotopes25O and26O

Author

Caesar, C., primary, Simonis, J., additional, Adachi, T., additional, Aksyutina, Y., additional, Alcantara, J., additional, Altstadt, S., additional, Alvarez-Pol, H., additional, Ashwood, N., additional, Aumann, T., additional, Avdeichikov, V., additional, Barr, M., additional, Beceiro, S., additional, Bemmerer, D., additional, Benlliure, J., additional, Bertulani, C. A., additional, Boretzky, K., additional, Borge, M. J. G., additional, Burgunder, G., additional, Caamano, M., additional, Casarejos, E., additional, Catford, W., additional, Cederkäll, J., additional, Chakraborty, S., additional, Chartier, M., additional, Chulkov, L., additional, Cortina-Gil, D., additional, Datta Pramanik, U., additional, Diaz Fernandez, P., additional, Dillmann, I., additional, Elekes, Z., additional, Enders, J., additional, Ershova, O., additional, Estrade, A., additional, Farinon, F., additional, Fraile, L. M., additional, Freer, M., additional, Freudenberger, M., additional, Fynbo, H. O. U., additional, Galaviz, D., additional, Geissel, H., additional, Gernhäuser, R., additional, Golubev, P., additional, Gonzalez Diaz, D., additional, Hagdahl, J., additional, Heftrich, T., additional, Heil, M., additional, Heine, M., additional, Heinz, A., additional, Henriques, A., additional, Holl, M., additional, Holt, J. D., additional, Ickert, G., additional, Ignatov, A., additional, Jakobsson, B., additional, Johansson, H. T., additional, Jonson, B., additional, Kalantar-Nayestanaki, N., additional, Kanungo, R., additional, Kelic-Heil, A., additional, Knöbel, R., additional, Kröll, T., additional, Krücken, R., additional, Kurcewicz, J., additional, Labiche, M., additional, Langer, C., additional, Le Bleis, T., additional, Lemmon, R., additional, Lepyoshkina, O., additional, Lindberg, S., additional, Machado, J., additional, Marganiec, J., additional, Maroussov, V., additional, Menéndez, J., additional, Mostazo, M., additional, Movsesyan, A., additional, Najafi, A., additional, Nilsson, T., additional, Nociforo, C., additional, Panin, V., additional, Perea, A., additional, Pietri, S., additional, Plag, R., additional, Prochazka, A., additional, Rahaman, A., additional, Rastrepina, G., additional, Reifarth, R., additional, Ribeiro, G., additional, Ricciardi, M. V., additional, Rigollet, C., additional, Riisager, K., additional, Röder, M., additional, Rossi, D., additional, Sanchez del Rio, J., additional, Savran, D., additional, Scheit, H., additional, Schwenk, A., additional, Simon, H., additional, Sorlin, O., additional, Stoica, V., additional, Streicher, B., additional, Taylor, J., additional, Tengblad, O., additional, Terashima, S., additional, Thies, R., additional, Togano, Y., additional, Uberseder, E., additional, Van de Walle, J., additional, Velho, P., additional, Volkov, V., additional, Wagner, A., additional, Wamers, F., additional, Weick, H., additional, Weigand, M., additional, Wheldon, C., additional, Wilson, G., additional, Wimmer, C., additional, Winfield, J. S., additional, Woods, P., additional, Yakorev, D., additional, Zhukov, M. V., additional, Zilges, A., additional, Zoric, M., additional, and Zuber, K., additional

Published
2013
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31. Recent developments for an active UF6 gas target for photon-induced fission experiments.

Author

Freudenberger, M., Eckardt, C., Enders, J., Göök, A., von Neumann-Cosel, P., Oberstedt, A., and Oberstedt, S.

Subjects
*URANIUM, *GAS detectors, *ELECTRONS, *VELOCITY, *PARTICLES (Nuclear physics)
Abstract

Recent developments for an active uranium-hexafluoride-loaded gas target as well as results on the detector gas properties are presented. The gas of choice is a mixture of argon with small amounts of UF6. This contribution presents the experimental setup and focusses on the electron drift velocity with increasing UF6 content. A time-dependent decrease in electron drift velocity is observed in our setup. [ABSTRACT FROM AUTHOR]

Published
2013
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32. 18P Relevance and Prediction of Breast Cancer Phenotype in Primary Tumor and its Positive Lymph Nodes and Later Disease Recurrence (Metastatic Breast Cancer): Results of the Primet-Trial (WSG / Detect)

Author

Wuerstlein, R., primary, Freudenberger, M., additional, Wildenburg, L., additional, Ortmann, M., additional, Liedtke, C., additional, Gluz, O., additional, Kates, R., additional, Fehm, T., additional, Nitz, U., additional, and Harbeck, N., additional

Published
2012
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34. Old Wind in New Bottles: Creating New Institutions for Local Land Management

Author

Bruce, J. W., Freudenberger, M. S., Ngaido, T., and Sustainable Agriculture and Natural Resource Management (SANREM) Knowledgebase

Subjects
Nationalism, Governance, Tenure system, Decentralization, Traditional, Legal, Decision making, Standardization, Modern
Abstract

Metadata only record The document reviews the experiences of Niger, Senegal, Botswana, Gambia, and Tanzania in their attempts to replace traditional community-based tenure systems with modern legal tenure systems based on national statutes. Most attempts race evolved into a second wave of adaptive tenure models using decentralized (local) decision-making to implement quasi-standardized tenure systems for each nation.

Published
1995

35. Reactions with polarized electrons and photons at low momentum transfers at the superconducting Darmstadt electron linear accelerator S–DALINAC

Author

Enders, J, primary, Bahlo, T, additional, Bangert, P, additional, Barday, R, additional, Brunken, M, additional, Eckardt, C, additional, Eichhorn, R, additional, Espig, M, additional, Freudenberger, M, additional, Göök, A, additional, Ingenhaag, C, additional, Lindemann, J, additional, Neumann-Cosel, P von, additional, Oberstedt, A, additional, Oberstedt, S, additional, Poltoratska, Y, additional, Richter, A, additional, Roth, M, additional, Schneider, F, additional, Wagner, M, additional, Weber, A, additional, and Zwicker, B, additional

Published
2011
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36. Abstract P4-06-22: Persistent Triple-Negative Phenotype Is Associated with Poorest Outcome among Patients with Metastatic Breast Cancer (BC) - Results of the Retrospective MulticenterPriMetStudy Comparing Molecular BC Phenotypes in Primary Tumors and Corresponding Recurrences

Author

Liedtke, C, primary, Gluz, O, additional, Heitz, F, additional, Freudenberger, M, additional, Würstlein, R, additional, Hungermann, D, additional, Ortmann, M, additional, Kates, RE, additional, Nitz, U, additional, du Bois, A, additional, Fehm, TN, additional, and Harbeck, N., additional

Published
2010
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37. The question of the commons in the Sahel

Author

Freudenberger, M. S., Mathieu, P., and Sustainable Agriculture and Natural Resource Management (SANREM) Knowledgebase

Subjects
Scarcity, Authority, Project strategies, Incentives, Communal pastures, Management regimes, Conditional exclusion, Common property resources, Ecosystem
Abstract

Metadata only record This report introduces common property regimes in the Sahel, establishes the conditions for the emergence of sustainable institutions to manage common property resources, and then concludes with policy recommendations. Available in SANREM office, FS

Published
1993

39. Pastoralism in Peril: The Compression of Grazing Space in Senegal

Author

Freudenberger, M. S., Freudenberger, K. S., Freudenberger, M. S., and Freudenberger, K. S.

Abstract

Land use patterns across Senegal's Sahelian zone are undergoing significant and rapid change. One particularly alarming aspect of this transformation is the unrelenting compression of once dynamic agro-pastoral livelihood systems into an ever more circumscribed space. The paper looks first at the agro-pastoral populations of Senegal and, in particular, at the role of mobility in reducing risk and ensuring the sustainability of their livelihood. It then discusses, region by region, the pressures on grazing lands, looking specifically at issues that have arisen (1) along the Senegal river and the Lac de Guiers, (2) in the Ferlo, (3) in the groundnut basin, (4) in the Niayes coastal region and (5) in Eastern Senegal and the Casamance. The conclusions focus on specific political and legal issues related to the maintenance of common areas necessary for agro-pastoralist livelihoods and looks at how the local populations themselves have responded to this threat to grazing strategies. (CAB Abstracts)

Published
1993

40. Pastoralism in Peril: The Compression of Grazing Space in Senegal

Author

Sustainable Agriculture and Natural Resource Management (SANREM) Knowledgebase, Freudenberger, M. S., Freudenberger, K. S., Sustainable Agriculture and Natural Resource Management (SANREM) Knowledgebase, Freudenberger, M. S., and Freudenberger, K. S.

Abstract

Land use patterns across Senegal's Sahelian zone are undergoing significant and rapid change. One particularly alarming aspect of this transformation is the unrelenting compression of once dynamic agro-pastoral livelihood systems into an ever more circumscribed space. The paper looks first at the agro-pastoral populations of Senegal and, in particular, at the role of mobility in reducing risk and ensuring the sustainability of their livelihood. It then discusses, region by region, the pressures on grazing lands, looking specifically at issues that have arisen (1) along the Senegal river and the Lac de Guiers, (2) in the Ferlo, (3) in the groundnut basin, (4) in the Niayes coastal region and (5) in Eastern Senegal and the Casamance. The conclusions focus on specific political and legal issues related to the maintenance of common areas necessary for agro-pastoralist livelihoods and looks at how the local populations themselves have responded to this threat to grazing strategies. (CAB Abstracts)

Published
1993

41. Feasibility Study for an Active 238UF6 Gas Target for Photo-Fission Experiments.

Author

Freudenberger, M., Eckardt, C., Göök, A., Enders, J., Hehner, J., von Neumann-Cosel, P., Oberstedt, A., Oberstedt, S., and Simon, H.

Subjects
PHOTOFISSION, LINEAR accelerators, ACTINIDE elements, IONIZATION (Atomic physics), SIGNAL processing, URANIUM
Abstract

Abstract: A series of fission experiments in the actinide region has been started at the superconducting Darmstadt linear accelerator S-DALINAC. For detailed investigations on, e.g., the energy dependence of fission modes, the population of fission isomers, or even the search for parity non-conservation effects (PNC) in the photon-induced fission process of 238U, high luminosities are needed. Increasing target thickness reduces mass and angular resolutions. One possible solution is the utilization of an active gas target containing UF6. In order to test UF6 as an admixture to standard counting gases (e.g. argon) and to study its properties, an ionization chamber has been built at Technische Universität Darmstadt. After testing the chamber with pure argon as a counting gas to evaluate signal quality and to determine the drift velocity, gaseous UF6 was filled into the chamber in steps of one mass-percent uranium for each measurement, where both signal quality and drift velocity at different admixtures have been determined. Up to two percent of uranium in the counting gas one finds that the drift velocity increases with UF6 content, while overall a good signal quality and energy resolution of the ionization chamber is preserved. [Copyright &y& Elsevier]

Published
2012
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42. Development of an Active 238UF6 Gas Target.

Author

Eckardt, C., Enders, J., Freudenberger, M., Gook, A., von Neumann-Cosel, P., Oberstedt, A., and Oberstedt, S.

Subjects
SUPERCONDUCTIVITY, URANIUM fluorides, ELECTRON accelerators, POLARIZATION (Nuclear physics), NUCLEAR spin, NUCLEAR energy, MOMENTUM transfer, THICKNESS measurement
Abstract

Abstract: At the superconducting 130 MeV Darmstadt electron linac S-DALINAC a new source of spin-polarized electrons using a GaAs cathode has been installed, opening the path for experiments with polarized electron and photon beams for nuclear structure studies at low momentum transfers, e.g., the search for forward-backward asymmetries originating from parity non-conservation (PNC) in the photon-induced fission process of 238U.Detailed studies of different properties, e.g., the energy dependence of fission modes, the population of fission isomers, or the search for (PNC) effects in the photon-induced fission process of 238U, depends on high quality data, therefore needing high luminosities. An active gas target containing uranium may overcome the problem that large solid target thicknesses cause poor energy and angular resolution.A single Frisch-grid ionization chamber has been built to test a mixture of standard counting gases (e.g., argon) with depleted uraniumhexafluoride (238UF6) using a triple alpha source, evaluating signal quality and drift velocity. For mass fractions up to 2 percent of 238U in the counting gas. The drift velocity increases with rising UF6 content, while a good signal quality and energy resolution is preserved. [Copyright &y& Elsevier]

Published
2012
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46. Correlated mass, energy, and angular distributions from bremsstrahlung-induced fission of 234U and 232Th in the energy region of the fission barrier.

Author

Göök, A., Eckardt, C., Enders, J., Freudenberger, M., Oberstedt, A., and Oberstedt, S.

Subjects
*ANGULAR distribution (Nuclear physics), *SUPERCONDUCTIVITY, *KINETIC energy
Abstract

The bremstrahlung-induced fission of 234U and 232Th has been studied at the superconducting Darmstadt linear accelerator (S-DALINAC) in the excitation energy region close to the fission barrier. Fission-fragment mass and total kinetic energy (TKE) distributions from 234U were studied for the first time in this energy region. The results have been analysed in terms of fission modes, and a dominant yield of the mass-asymmetric standard-2 mode was found in both nuclei. No strong dependence of the fission-mode weights on the excitation energy of the compound nucleus was found. Correlations among mass, TKE, and angular distributions have also been investigated. A correlation in the form of an increased anisotropy for far-asymmetric masses and low TKE were found in both fissioning systems. A possible interpretation of this correlation in terms of fission modes is discussed. [ABSTRACT FROM AUTHOR]

Published
2017
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47. Phenotype Discordance between Primary Tumor and Metastasis Impacts Metastasis Site and Outcome: Results of WSG-DETECT-PriMet.

Author

Kolberg-Liedtke C, Wuerstlein R, Gluz O, Heitz F, Freudenberger M, Bensmann E, du Bois A, Nitz U, Pelz E, Warm M, Ortmann M, Sultova E, Brucker SY, Kates RE, Fehm T, and Harbeck N

Abstract

Introduction: Tumor biological factors of breast cancer (BC) such as hormone receptor (HR) status, HER2 status, and grade can differ in the metastatic cascade from primary to lymph node (LN) metastasis and to distant metastatic tissue. Systematic data regarding therapeutic consequences are yet limited., Methods: We conducted a prospectively planned, retrospective cohort study comparing BC phenotype in tissue from primary tumors (PTs), locoregional LN metastases, and disease recurrence (DR). HR and HER2 as well as tumor grade in PTs and DR were obtained by a database search. No centralized biomarker testing was performed. The impact of changes in tumor biological factors on post-recurrence survival (PRS) and overall survival was analyzed., Results: PriMet comprises 635 patients (LN tissue in 142 patients). Discrepancies for HR or HER2 status between PT and DR were observed in 18.7 and 21.6% of cases, respectively. For HR status, positivity of PT and negativity of DR was seen more often (13.2%) than vice versa (5.5%). For HER2 status, negativity of the primary and positivity of DR was seen more often (14.9%) than vice versa (6.7%). Discordance was more often observed between PT and LN metastasis compared to LN versus DR. However, numbers were small. Compared to concordant non-triple-negative (TN) disease, concordant TN disease showed significantly inferior PRS., Conclusion: We demonstrate receptor discordance to occur relatively frequently between PT, LN metastasis, and DR and to impact patient prognosis. However, clinical consequences of receptor discordance need to be drawn with caution considering clinical aspects as well as tumor biology., Competing Interests: C. Kolberg-Liedtke has received honoraria/travel support by Phaon Scientific, Novartis, Pfizer, Celgene, Roche, AstraZeneca, Lilly, HEXAL, Amgen, Eisai, and SonoScape and has received research funding by Roche, Novartis, and Pfizer (CKL). O. Gluz has received lecture/consultancy fees from Celgene, Roche, Genomic Health, Amgen, Pfizer, Novartis, Lilly, Nanostring, Eisai, and MSD, and assistance with travel costs from Celgene, Roche, and Daiichi-Sankyo. N. Harbeck has received honoraria for lectures and/or consulting from Agendia, Amgen, Astra Zeneca, BMS, Celgene, Daiichi-Sankyo, Genomic Health, Lilly, MSD, Novartis, Odonate, Pierre Fabre, Pfizer, Roche, Sandoz/Hexal, and Seattle Genetics. R. Wuerstlein, M. Freudenberger, E. Bensmann, A. du Bois, U. Nitz, E. Pelz, M. Warm, M. Ortmann, E. Sultova, S.Y. Brucker, R.E. Kates, and T. Fehm state that they have no conflict of interest regarding the paper., (Copyright © 2020 by S. Karger AG, Basel.)

Published
2021
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48. D-Light on promoters: a client-server system for the analysis and visualization of cis-regulatory elements.

Author

Laimer J, Zuzan CJ, Ehrenberger T, Freudenberger M, Gschwandtner S, Lebherz C, and Lackner P

Subjects
Binding Sites, Computer Graphics, Genome, Transcription Factors metabolism, Promoter Regions, Genetic, Software
Abstract

Background: The binding of transcription factors to DNA plays an essential role in the regulation of gene expression. Numerous experiments elucidated binding sequences which subsequently have been used to derive statistical models for predicting potential transcription factor binding sites (TFBS). The rapidly increasing number of genome sequence data requires sophisticated computational approaches to manage and query experimental and predicted TFBS data in the context of other epigenetic factors and across different organisms., Results: We have developed D-Light, a novel client-server software package to store and query large amounts of TFBS data for any number of genomes. Users can add small-scale data to the server database and query them in a large scale, genome-wide promoter context. The client is implemented in Java and provides simple graphical user interfaces and data visualization. Here we also performed a statistical analysis showing what a user can expect for certain parameter settings and we illustrate the usage of D-Light with the help of a microarray data set., Conclusions: D-Light is an easy to use software tool to integrate, store and query annotation data for promoters. A public D-Light server, the client and server software for local installation and the source code under GNU GPL license are available at http://biwww.che.sbg.ac.at/dlight.

Published
2013
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49. Expression and activity of alcohol and aldehyde dehydrogenases in melanoma cells and in melanocytes.

Author

Amann PM, Hofmann C, Freudenberger M, Holland-Cunz S, Eichmüller SB, and Bazhin AV

Subjects
Alcohol Dehydrogenase genetics, Aldehyde Dehydrogenase genetics, Cell Line, Cell Line, Tumor, Humans, Melanocytes drug effects, RNA, Messenger metabolism, Retinaldehyde pharmacology, Alcohol Dehydrogenase metabolism, Aldehyde Dehydrogenase metabolism, Melanocytes enzymology, Melanoma enzymology
Abstract

Disturbances in vitamin A metabolism are an important attribute of some cancer cells. Most evidence point that these disturbances lead to decreasing of the retinoic acid concentration in tumor cells. Up to now, in benign and malignant skin cells the features of vitamin A metabolism with its participating enzymes are not entirely understood. Alcohol and aldehyde dehydrogenases (ALDH) are involved in the retinol metabolism, oxidizing retinol, and retinal in retinoic acid or reducing retinal in retinol. In this work we investigated the expression and enzymatic activity of alcohol and ALDH in melanoma cells compared to their benign counterparts. We demonstrated that melanoma cell lines and melanocytes despite similar pattern of the enzyme expression, show different general ALDH activity. Retinal, the substrate of ALDH, could stimulate the ALDH activity through up-regulation of retinaldehyde dehydrogenase 1 and aldehyde dehydrogenase 6. Furthermore, we found that retinoids regulate alcohol dehydrogenase activity, probably via effects on alcohol dehydrogenase expression at the post-transcriptional level. We suggest that melanoma cells in contrast to melanocytes should favor the retinal reduction over its oxidation. The decreasing cellular amount of the precursor molecules of retinoic acid could result in a changed gene regulation in melanoma cells., (Copyright © 2011 Wiley Periodicals, Inc.)

Published
2012
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50. Vitamin A metabolism in benign and malignant melanocytic skin cells: importance of lecithin/retinol acyltransferase and RPE65.

Author

Amann PM, Luo C, Owen RW, Hofmann C, Freudenberger M, Schadendorf D, Eichmüller SB, and Bazhin AV

Subjects
Acyltransferases genetics, Carrier Proteins genetics, Carrier Proteins metabolism, Cell Line, Tumor, Eye Proteins genetics, Eye Proteins metabolism, Gene Expression Regulation, Enzymologic drug effects, Gene Expression Regulation, Enzymologic physiology, Gene Expression Regulation, Neoplastic drug effects, Gene Expression Regulation, Neoplastic physiology, Humans, Melanocytes cytology, RNA Interference, RNA, Messenger genetics, RNA, Messenger metabolism, Receptors, Retinoic Acid genetics, Receptors, Retinoic Acid metabolism, Retinoid X Receptors genetics, Retinoid X Receptors metabolism, Retinol-Binding Proteins, Cellular genetics, Retinol-Binding Proteins, Cellular metabolism, Tretinoin, cis-trans-Isomerases, Acyltransferases metabolism, Melanocytes metabolism, Melanoma metabolism, Vitamin A pharmacology
Abstract

Disturbance in vitamin A metabolism seems to be an important attribute of cancer cells. Retinoids, particularly retinoic acid, have critical regulatory functions and appear to modulate tumor development and progression. The key step of vitamin A metabolism is the esterification of all-trans retinol, catalyzed by lecithin/retinol acyltransferase (LRAT). In this work, we show that malignant melanoma cells are able to esterify all-trans retinol and subsequently isomerize all-trans retinyl esters (RE) into 11-cis retinol, whereas their benign counterparts-melanocytes are not able to catalyze these reactions. Besides, melanoma cell lines express lecithin/retinol acyltranseferase both at the mRNA and protein levels. In contrast, melanocytes do not express this enzyme at the protein level, but mRNA of lecithin/retinol acyltransefrase could still be present at mRNA level. RPE65 is expressed in both melanocytic counterparts, and could be involved in the subsequent isomerization of RE produced by lecithin/retinol acyltransefrase to 11-cis retinol. Cellular retinol-binding protein 2 does not appear to be involved in the regulation of all-trans retinol esterification in these cells. Expression of LRAT and RPE65 can be modulated by retinoids. We propose that the post-transcriptional regulation of lecithin/retinol acyltransefrase could be involved in the differential expression of this enzyme. Besides, activities of LRAT and RPE65 may be important for removal of all-trans retinal which is the substrate for retinoic acid production in skin cells. Consequently, the decreasing cellular amount of retinoic acid and its precursor molecules could result in a change of gene regulation., (Copyright © 2011 Wiley Periodicals, Inc.)

Published
2012
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