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147 results on '"Frenzel, K."'

11. Abstract OT2-06-01: Highly innovative personalized RNA-immunotherapy for patients with triple negative breast cancer

Author

Schmidt, M, primary, Bolte, S, additional, Frenzel, K, additional, Heesen, L, additional, Derhovanessian, E, additional, Bukur, V, additional, Diken, M, additional, Gruetzner, J, additional, Kreiter, S, additional, Klein, A, additional, Kuhn, A, additional, Langer, D, additional, Loewer, M, additional, Lindman, H, additional, Schneeweiss, A, additional, Tuereci, O, additional, and Sahin, U, additional

Published
2019
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13. Mutanome engineered RNA immuno-therapy (MERIT) for patients with triple negative breast cancer (TNBC)

Author

Heesen, L., primary, Frenzel, K., additional, Bolte, S., additional, Bukur, V., additional, Diken, M., additional, Derhovanessian, E., additional, Kreiter, S., additional, Kuhn, A., additional, Kühlcke, K., additional, Löwer, M., additional, Lindman, H., additional, Pascolo, S., additional, Schmidt, M., additional, Schneeweiss, A., additional, Sjöblom, T., additional, Thielemans, K., additional, Zitvogel, L., additional, Türeci, Ö, additional, and Sahin, U., additional

Published
2018
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16. Mutanome engineered RNA immuno-therapy (MERIT) for patients with triple negative breast cancer

Author

Frenzel, K., Heesen, L., Bolte, S., Bukur, V., Diken, M., Derhovanessian, E., Kreiter, S., Kuhn, A., Kuehlcke, K., Löwer, M., De Greve, J., Lindman, Henrik, Pascolo, S., Schmidt, M., Schneeweiss, A., Sjöblom, Tobias, Thielemans, K., Zitvogel, L., Tuereci, Ö., Sahin, U., Frenzel, K., Heesen, L., Bolte, S., Bukur, V., Diken, M., Derhovanessian, E., Kreiter, S., Kuhn, A., Kuehlcke, K., Löwer, M., De Greve, J., Lindman, Henrik, Pascolo, S., Schmidt, M., Schneeweiss, A., Sjöblom, Tobias, Thielemans, K., Zitvogel, L., Tuereci, Ö., and Sahin, U.

Published
2017
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17. Mutanome engineered RNA immuno-therapy (MERIT) for patients with triple negative breast cancer

Author

Frenzel, K., primary, Heesen, L., additional, Bolte, S., additional, Bukur, V., additional, Diken, M., additional, Derhovanessian, E., additional, Kreiter, S., additional, Kuhn, A., additional, Kuehlcke, K., additional, Löwer, M., additional, De Greve, J., additional, Lindman, H., additional, Pascolo, S., additional, Schmidt, M., additional, Schneeweiss, A., additional, Sjöblom, T., additional, Thielemans, K., additional, Zitvogel, L., additional, Türeci, Ö, additional, and Sahin, U., additional

Published
2017
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19. USP18 lack in microglia causes destructive interferonopathy of the mouse brain

Author

Goldmann, T. (Tobias), Zeller, N. (Nicolas), Raasch, J. (Jenni), Kierdorf, K. (Katrin), Frenzel, K. (Kathrin), Ketscher, L. (Lars), Basters, A. (Anja), Staszewski, O. (Ori), Brendecke, S.M. (Stefanie M.), Spiess, A. (Alena), Tay, T.L. (Tuan Leng), Kreutz, C. (Clemens), Timmer, J. (Jens), Mancini, G.M.S. (Grazia), Blank, T. (Thomas), Fritz, G. (Günter), Biber, K.P.H. (Knut), Lang, R. (Roland), Malo, D. (Danielle), Merkler, D. (Doron), Heikenwälder, M. (Mathias), Knobeloch, K.-P. (Klaus-Peter), Prinz, M. (Marco), Goldmann, T. (Tobias), Zeller, N. (Nicolas), Raasch, J. (Jenni), Kierdorf, K. (Katrin), Frenzel, K. (Kathrin), Ketscher, L. (Lars), Basters, A. (Anja), Staszewski, O. (Ori), Brendecke, S.M. (Stefanie M.), Spiess, A. (Alena), Tay, T.L. (Tuan Leng), Kreutz, C. (Clemens), Timmer, J. (Jens), Mancini, G.M.S. (Grazia), Blank, T. (Thomas), Fritz, G. (Günter), Biber, K.P.H. (Knut), Lang, R. (Roland), Malo, D. (Danielle), Merkler, D. (Doron), Heikenwälder, M. (Mathias), Knobeloch, K.-P. (Klaus-Peter), and Prinz, M. (Marco)

Abstract

Microglia are tissue macrophages of the central nervous system (CNS) that control tissue homeostasis. Microglia dysr

Published
2015
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24. Oesophagostomum bifurcum-induced nodular pathology in a highly endemic area of Northern Ghana

Author

Ziem, J. B., Spannbrucker, N., Magnussen, P., Olsen, A., Amon-Kotey, D. Nii, Frenzel, K., Nang-beifubah, A., Westendorp, R. G.J., Polderman, A. M., Ziem, J. B., Spannbrucker, N., Magnussen, P., Olsen, A., Amon-Kotey, D. Nii, Frenzel, K., Nang-beifubah, A., Westendorp, R. G.J., and Polderman, A. M.

Abstract

Human infection with Oesophagostomum bifurcum is rare globally, but focally endemic and common in Ghana and Togo. Two clinical presentations are identified: uni-nodular disease, which may be recognized as a 'Dapaong Tumour', and multi-nodular disease. Here, we describe the prevalence of O. bifurcum infection and the association with nodular pathology in northern Ghana. The study was performed in October 2002. Out of a well-defined population of approximately 18 000, 928 subjects of all ages were randomly selected for parasitological and ultrasound examination. In stool cultures, 44% had detectable third-stage O. bifurcum larvae present. Females were more often infected than males (P < 0.05). In 34% of the samples, nodules were detected along the colon wall, with the ascending and the transverse colon being the most affected regions. Significant correlations existed between the intensity of infection and the presence of nodules, both at the village and the individual level (P < 0.001 for both). Patients with multi-nodular pathology had significantly higher larval counts than patients with uni-nodular pathology. The present data suggest that nodular pathology, and probably the severity of the disease, are directly related to intensity of the infection.

Published
2005

37. Transmembrane neuregulins interact with LIM kinase 1, a cytoplasmic protein kinase implicated in development of visuospatial cognition.

Author

Wang, J Y, Frenzel, K E, Wen, D, and Falls, D L

Abstract

The neuregulins are receptor tyrosine kinase ligands that play a critical role in the development of the heart, nervous system, and breast. Unlike many extracellular signaling molecules, such as the neurotrophins, most neuregulins are synthesized as transmembrane proteins. To determine the functions of the highly conserved neuregulin cytoplasmic tail, a yeast two-hybrid screen was performed to identify proteins that interact with the 157-amino acid sequence common to the cytoplasmic tails of all transmembrane neuregulin isoforms. This screen revealed that the neuregulin cytoplasmic tail interacts with the LIM domain region of the nonreceptor protein kinase LIM kinase 1 (LIMK1). Interaction between the neuregulin cytoplasmic tail and full-length LIMK1 was demonstrated by in vitro binding and co-immunoprecipitation assays. Transmembrane neuregulins with each of the three known neuregulin cytoplasmic tail isoforms interacted with LIMK1. In contrast, the cytoplasmic tail of TGF-alpha did not interact with LIMK1. In vivo, neuregulin and LIMK1 are co-localized at the neuromuscular synapse, suggesting that LIMK1, like neuregulin, may play a role in synapse formation and maintenance. To our knowledge, LIMK1 is the first identified protein shown to interact with the cytoplasmic tail of a receptor tyrosine kinase ligand.

Published
1998

49. Complementary techniques for the reliable characterisation of tissue samples: A case study on pancreatic tumours analysed by means of X-ray fluorescence analysis and IR spectroscopy.

Author

Frenzel K, Kayser Y, Hornemann A, Kästner B, Hoehl A, Mouratidis P, Rivens I, Ter Haar G, and Beckhoff B

Subjects
Animals, Mice, Spectroscopy, Fourier Transform Infrared methods, Carcinoma, Pancreatic Ductal pathology, Carcinoma, Pancreatic Ductal diagnostic imaging, Pancreatic Neoplasms pathology, Pancreatic Neoplasms diagnostic imaging, Pancreatic Neoplasms radiotherapy, Spectrometry, X-Ray Emission methods
Abstract

An improvement in the reliability and comparability of tissue characterization results is crucial for enabling further progress in cancer detection and the assessment of therapeutic effects. This can only be achieved by integrating quantitative methods into well-established qualitative characterization routines. This case study presents a hybrid metrological approach for tissue characterisation including vibrational Fourier Transform InfraRed (FTIR) spectroscopy and traceable reference-free X-Ray Fluorescence analysis (XRF). Through the combination of spatially resolved qualitative molecular information with quantitative elemental concentrations an all-encompassing sample characterisation can be provided. The study was performed on tissue sections of syngeneic murine pancreatic ductal adenocarcinoma KPC (KrasG12D/+; Trp53R172H/+; Pdx-1-Cre) tumours ex-vivo. Sections from healthy pancreatic tissues, sham-exposed tumours and tumours subjected to low dose radiotherapy treatment (2 Gray and 6 Gray) were analysed using both methods. Additional sample integrity studies using Near Edge X-ray Absorption Fine Structure (NEXAFS) spectroscopy at the carbon and nitrogen K-edges were performed to assess the effect of sample aging and XRF investigations on the samples. Results showed an increase in the concentrations of elemental biomarkers, including S, K and amide I structures in malignant pancreatic tissue compared to healthy pancreatic tissue. The exposure of tumours to 6 Gy radiation decreases the levels of these elements towards a phenotype seen in the healthy pancreas. A protocol for hybrid investigations is presented, with emphasis on the sample preparation, minimizing the impact of consecutive applied methods on their measurands, and ensuring the compatibility and reliability of achieved results. The study demonstrates the cancer recognition capabilities, and the sensitivity for low dosage radiotherapy treatment monitoring for each method individually and assesses the potential of combining molecular fingerprinting with non-destructive quantitative elemental information for tissue sample characterization., Competing Interests: The authors have read the journal’s policy and have the following competing interests: KF, YK, AH, BK, AH, PM, IR, GterH, and BB are employees of EURAMET, European Association of National Metrology Institutes (https://www.euramet.org). PM, IR, and GterH are also employees of Focused Ultrasound Foundation and Pancreatic Cancer UK. This does not alter our adherence to PLOS ONE policies on sharing data and materials. There are no patents, products in development or marketed products associated with this research to declare., (Copyright: © 2024 Frenzel et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)

Published
2024
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