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Background: Information on vaccine effectiveness in a context of novel variants of concern (VOC) emergence is of key importance to inform public health policies. This study aimed to estimate a measure of comparative vaccine effectiveness between Omicron (BA.1) and Delta (B.1.617.2 and sub-lineages) VOC according to vaccination exposure (primary or booster). Methods: We developed a case–case study using data on RT-PCR SARS-CoV2-positive cases notified in Portugal during Weeks 49–51, 2021. To obtain measure of comparative vaccine effectiveness, we compared the odds of vaccination in Omicron cases versus Delta using logistic regression adjusted for age group, sex, region, week of diagnosis, and laboratory of origin. Results: Higher odds of vaccination were observed in cases infected by Omicron VOC compared with Delta VOC cases for both complete primary vaccination (odds ratio [OR] = 2.1; 95% confidence interval [CI]: 1.8 to 2.4) and booster dose (OR = 5.2; 95% CI: 3.1 to 8.8), equivalent to reduction of vaccine effectiveness from 44.7% and 92.8%, observed against infection with Delta, to 6.0% (95% CI: 29.2% to 12.7%) and 62.7% (95% CI: 35.7% to 77.9%), observed against infection with Omicron, for complete primary vaccination and booster dose, respectively. Conclusion: Consistent reduction in vaccine-induced protection against infection with Omicron was observed. Complete primary vaccination may not be protective against SARS-CoV-2 infection in regions where Omicron variant is dominant. Grant no. 2021/PHF/23776; POCI-01-0145-FEDER-022184; Project ALG-D2-2021-06 info:eu-repo/semantics/publishedVersion

Submitted by Claudina Moraes (camclaudina@gmail.com) on 2016-06-24T20:21:40Z No. of bitstreams: 1 Disserta????o - Samanta Ara??jo Freire.pdf: 1892629 bytes, checksum: f91cc8517d9d407a1383016ec826a6b1 (MD5) Approved for entry into archive by Divis??o de Documenta????o/BC Biblioteca Central (ddbc@ufam.edu.br) on 2016-07-11T14:57:00Z (GMT) No. of bitstreams: 1 Disserta????o - Samanta Ara??jo Freire.pdf: 1892629 bytes, checksum: f91cc8517d9d407a1383016ec826a6b1 (MD5) Approved for entry into archive by Divis??o de Documenta????o/BC Biblioteca Central (ddbc@ufam.edu.br) on 2016-07-11T14:57:28Z (GMT) No. of bitstreams: 1 Disserta????o - Samanta Ara??jo Freire.pdf: 1892629 bytes, checksum: f91cc8517d9d407a1383016ec826a6b1 (MD5) Made available in DSpace on 2016-07-11T14:57:28Z (GMT). No. of bitstreams: 1 Disserta????o - Samanta Ara??jo Freire.pdf: 1892629 bytes, checksum: f91cc8517d9d407a1383016ec826a6b1 (MD5) Previous issue date: 2015-10-28 FAPEAM - Funda????o de Amparo ?? Pesquisa do Estado do Amazonas In the contemporaneous world, the labor market is in constant transformation due to the inclusion of new technologies and forms of organization of the productive process, which demands from the worker the development of skills that will enable their permanence in the job before a competitive scenario. In the case of workers with disability, remain inserted in the labor market is even more difficult due to several factors, whether of social, economic and even cultural order, that???s why the qualification represents a fundamental weapon for this group, as a way to make effective their inclusion both professional and social. Given the above, the present dissertation aims to analyze the social contribution of professional qualification programs for people with disability in the city of Manaus, with emphasis on the preparing of this group for the labor market. It still has as specific objectives, understand the fundamental aspects of disability through concepts, terminologies and models; know the historical and social evolution of people with disability; understand the work world and labor laws, especially those governing the National Policy for the Integration of People with Disability; and verify, at the municipal level, the dynamics of the labor market and the working process of professional qualification programs for people with disability. For the research, were chosen two professional qualification programs developed in Manaus: the Curupira Project, from the Federal Institute of Education, Science and Technology of Amazon (IFAM), and the Program SENAI of Inclusive Actions, this one in period from 2012 to 2014. The research was based on quantitative and qualitative approach, of descriptive, bibliographical and documentary character, because were used theoretical references and internal documents related to the operation of the programs. The research method used was dialectical, because the aim was to understand the dynamics of the programs, from the relationship these establish with the other spheres of society. The field study was conducted through questionnaires, with the participation of students and coordinators, as well as documentary study in loco with the help of employees who work in the programs. The results allowed concluding that in some cases the programs' social contribution goes beyond offering the qualification for the job, as it contributes to the development of the autonomy and independence of the individual. In such cases, it was observed that the inclusion in the labor market is carried out effectively, bringing life improvements to these workers with disability. No mundo contempor??neo, o mercado de trabalho encontra-se em constante transforma????o devido ?? inclus??o de novas tecnologias e formas de organiza????o do processo produtivo, o que exige do trabalhador o desenvolvimento de compet??ncias que possibilitem sua perman??ncia no emprego diante de um cen??rio t??o competitivo. No caso do trabalhador com defici??ncia, manter-se inserido no mercado de trabalho ?? ainda mais dif??cil devido a v??rios fatores, seja de ordem social, econ??mica ou at?? mesmo cultural, por isso a qualifica????o profissional representa uma arma fundamental para esse grupo como forma de efetivar sua inclus??o tanto profissional quanto social. Diante do exposto, a presente disserta????o tem como objetivo principal, analisar a contribui????o social dos programas de qualifica????o profissional para pessoas com defici??ncia no munic??pio de Manaus, com ??nfase na prepara????o desse grupo para o mercado de trabalho. Tem ainda como objetivos espec??ficos, entender os principais aspectos da defici??ncia atrav??s de conceitos, terminologias e modelos; conhecer a evolu????o hist??rica e social das pessoas com defici??ncia; compreender o mundo do trabalho e as legisla????es trabalhistas, principalmente as que regulamentam a Pol??tica Nacional para a Integra????o da Pessoa Portadora de Defici??ncia; e verificar, a n??vel municipal, a din??mica do mercado de trabalho e o processo de funcionamento dos programas de qualifica????o profissional para pessoas com defici??ncia. Para a realiza????o da pesquisa, foram escolhidos dois programas de qualifica????o profissional desenvolvidos em Manaus: o Projeto Curupira, do Instituto Federal de Educa????o, Ci??ncia e Tecnologia do Amazonas (IFAM), e o Programa SENAI de A????es Inclusivas, este no per??odo de 2012 a 2014. A investiga????o baseou-se na abordagem quanti-qualitativa, de car??ter descritivo, bibliogr??fico e documental, pois foram utilizados tanto referenciais te??ricos, quanto documentos internos referentes ao funcionamento dos programas. O m??todo de pesquisa utilizado foi o dial??tico, pois se pretendeu compreender a din??mica dos programas a partir da rela????o que estes estabelecem com as demais esferas da sociedade. O trabalho de campo foi desenvolvido atrav??s de question??rios, com a participa????o de alunos e coordenadores, al??m de estudo documental in loco com o aux??lio de colaboradores que atuam nos programas. Os resultados obtidos permitiram concluir que em alguns casos a contribui????o social dos programas vai al??m da oferta da qualifica????o para o trabalho, uma vez que contribui para o desenvolvimento da autonomia e independ??ncia do individuo. Nesses casos, observou-se que a inclus??o no mercado de trabalho ?? realizada de forma efetiva, trazendo melhorias de vida para esses trabalhadores com defici??ncia.