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1. Guidance on mucositis assessment from the MASCC Mucositis Study Group and ISOO: an international Delphi study.

Author

Abdalla-Aslan, Ragda, Bonomo, Pierluigi, Keefe, Dorothy, Blijlevens, Nicole, Cao, Katrina, Cheung, Yin, Fregnani, Eduardo, Miller, Robert, Raber-Durlacher, Judith, Epstein, Joel, Van Sebille, Ysabella, Kauark-Fontes, Elisa, Kandwal, Abhishek, McCurdy-Franks, Emma, Finkelstein, Joel, McCarvell, Victoria, Zadik, Yehuda, Ottaviani, Giulia, Amaral Mendes, Rui, Speksnijder, Caroline, Wardill, Hannah, and Bossi, Paolo

Subjects
Gastrointestinal mucositis, Mucositis assessment tools, Oral mucositis, Patient-reported outcome measures
Abstract

BACKGROUND: Mucositis is a common and highly impactful side effect of conventional and emerging cancer therapy and thus the subject of intense investigation. Although common practice, mucositis assessment is heterogeneously adopted and poorly guided, impacting evidence synthesis and translation. The Multinational Association of Supportive Care in Cancer (MASCC) Mucositis Study Group (MSG) therefore aimed to establish expert recommendations for how existing mucositis assessment tools should be used, in clinical care and trials contexts, to improve the consistency of mucositis assessment. METHODS: This study was conducted over two stages (January 2022-July 2023). The first phase involved a survey to MASCC-MSG members (January 2022-May 2022), capturing current practices, challenges and preferences. These then informed the second phase, in which a set of initial recommendations were prepared and refined using the Delphi method (February 2023-May 2023). Consensus was defined as agreement on a parameter by >80% of respondents. FINDINGS: Seventy-two MASCC-MSG members completed the first phase of the study (37 females, 34 males, mainly oral care specialists). High variability was noted in the use of mucositis assessment tools, with a high reliance on clinician assessment compared to patient reported outcome measures (PROMs, 47% vs 3%, 37% used a combination). The World Health Organization (WHO) and Common Terminology Criteria for Adverse Events (CTCAE) scales were most commonly used to assess mucositis across multiple settings. Initial recommendations were reviewed by experienced MSG members and following two rounds of Delphi survey consensus was achieved in 91 of 100 recommendations. For example, in patients receiving chemotherapy, the recommended tool for clinician assessment in clinical practice is WHO for oral mucositis (89.5% consensus), and WHO or CTCAE for gastrointestinal mucositis (85.7% consensus). The recommended PROM in clinical trials is OMD/WQ for oral mucositis (93.3% consensus), and PRO-CTCAE for gastrointestinal mucositis (83.3% consensus). INTERPRETATION: These new recommendations provide much needed guidance on mucositis assessment and may be applied in both clinical practice and research to streamline comparison and synthesis of global data sets, thus accelerating translation of new knowledge into clinical practice. FUNDING: No funding was received.

Published
2024

3. Guidance on mucositis assessment from the MASCC Mucositis Study Group and ISOO: an international Delphi study

Author

Laheij, Alexa, Tonkaboni, Arghavan, Scott, Jacqui, Abasaeed, Rania, Kauzman, Adel, Flato, Adriana Do Socorro Lima, Gore, Adwaita, Hardman, Anne-Marie, Horvath, Agnes, Hovan, Allan, Al-Jamaei, Aisha, koizumi, Aya, Santos-Silva, Alan, Majorana, Alessandra, Giannini, Alexandre, Teixeira, Aléxia, Shazib, Muhammad Ali, Melvin, Alison, Filho, Aluísio Miranda, Gruza, Amanda, Brown-Dahl, Amber, Harilall, Amit, El Maghrabi, Amr, Rogulj, Ana Andabak, Curvo, Ana Raphaela, Soares, Ana Laura, Stringer, Andrea, Moreira, Andréa, Kurtzweil, Andy, Salaberry, Angelyn, Blazy, Anne, Gussgard, Anne Margrete, Lynge Pedersen, Anne Marie, Freidank, Annette, Ariyawardana, Anura, Ramseier, Adrian, Arends, Jann, Blanchard, Ariel, Paz, Adriana Sesti, Thermann, Angela, Poropat, Augusto, Freites-Martinez, Azael, Al-Azri, Abdul Rahman, Herlofson, Bente Brokstad, BalajiSubramanian, Sitaraman, Ballantyne, Barbara, Bektas-Kayhan, Kivanc, Hasséus, Bengt, Kaffenberger, Benjamin, Benites, Bernar, Kwong, Bernice, Test, Beth, Chiantia, Fernando, Pettersson, Bo, Framroze, Bomi, Bonomo, Pierluigi, Brzak, Božana Lončar, Dulmage, Brittany, Buga, Sorin, Spekssnijder, Caroline, Brown, Carlton, Melo, Antonio Carlos Moura de, Ribeiro, Ana Carolina, Silva, Caroline, Fulop, Caroline, Anderson, Carryn, Flaitz, Catherine, Massoud, Cathy, Migliorati, Cesar, Gross, Callie, Gandini, Chiara, Loprinzi, Charles, de Mooij, Charlotte, Hong, Catherine, Choi, Ying Chu, Choy, Maria, Boers-Doets, Christine, Schmeel, Leonard, Nagano, Cibele, Franco, Maria Coeli, Subramaniam, Courtney, Patrick, Carolyn, Poh, Catherine, Neuenschwander, Cristina, Virgen, Cesar, Riesenbeck, Dorothea, Weaver, Dale, Goldemberg, Daniel Cohen, Sundaresan, Daniel, Nunes, Daniela, Perez, Danyel, Travassos, Daphine, Yang, David, Ribeiro, Daniela, Kolbinson, Dean, Buick, Deborah, Saunders, Deborah, De Bortolli, Juliane, Chugh, Deepika, Markstrom, Denise, Travassos, Denise, Weikel, Dianna, Galiti, Dimitra, Peiris, Dinusha, Djordjevic, Fedja, Singhai, Pankaj, Keefe, Dorothy, Peterson, Douglas, Fonseca, Douglas, Pon, Doreen, Kovalenko, Iuliia, Polonskaia, Aleksandra, Caldas, Rogério, Saganski, Kevin, Néri, Julia, Abbott, Dennis, Yergolkar, Abhijna Vithal, Del Conte, Cristina, Passos, Januaria, Uezu, Katia, Silva, Paula, Gilbert, Steven, Yeoh, Keng, Jain, Kunal, Rastogi, Madhup, Sankaran, Satheeshkumar Poolakkad, Manne, Deborah, Shatokhina, Evgeniya, Adebayo-Olojo, Esther, Somogyi-Ganss, Eszter, Ehrenpreis, Eli, Bernaola-Paredes, Wilber, Fregnani, Eduardo, Cardoso, Elaci, Bardellini, Elena, Arvanitou, Eleni, Fontes, Elisa Kauark, Bruning, Elise, Neumann, Eloise, Madureira, Elsa, Ramires, Marcia, Papadopoulou, Erofili, Munhoz, Etiene, Spijkervet, Fred, Granzotto, Fabiana, Martins, Fabiana, Alves, Fabio, Mougeot, Farah, Aielli, Federica, Pigatti, Fernanda, Fonseca, Fernanda, Samim, Firoozeh, Carvalho, Flavia, Zelaya, Florence Cuadra, Freytes, Cesar, da Silveira, Gabriela, Torino, Gabriela, Martins, Gabriela, Silva, Geisa, Caro, Gemma, Bryan, Gemma, Radford, Georgette, Al-Qadami, Ghanyah, Albini, Giorgia, Mainville, Gisele, Gkardiakos, Georgios, Potter, Gleidston, Hoeberechts, Gulbin, Howarth, Gordon, Ottaviani, Giulia, Bradley, Grace, Verma, Gunjan, Santos, Gustavo dos, Randles-Guzzardi, Margaret, Engelbrecht, Hanlie, Wardill, Hannah, Hansen, Heidi, Hasan, Iquebal, Hata, Hironobu, Ullgren, Helena, Antunes, Heliton Spindola, Laís dos Santos, Heloísa, Weld, Howard, McInnes, Helen, Jungbluth, Hans Peter, Weng, Hsiaofen, Hewson, Ian, Santos, Ingrid, Illarramendi, Jorge, Semendric, Ines, Menge, Rol, Von Bultzingslowen, Inger, Melo, Maria da Gloria de, Leong, Iona, Fonseca, Isabella, Kalif, Isadora, Carroll, James, Coller, Janet, Beck-Mannagetta, Johann, Bowen, Joanne, Meurer, Jose, McCullough, Ricky, Powers, Jennifer, Gomez, Jesus, Lenjisa, Jimma, jaya Vangara, Leko, Jasna, Fall-Dickson, Jane, Mougeot, Jean-Luc, Fox, Joan, Epstein, Joel, Robijns, Jolien, Wu, Jonn, Palma, Patricio, Amaram-Davila, Jaya, Siderov, Jim, Raber-Durlacher, Judith, Dantas, Juliana, Jasper, Juliana, Monteiro, Juliana, Bruno, Julia, julie pfeffer, Ristivojevic, Julija Jovanovic, Brito, Juliana, Kuriakose, Jyothsna, Kabasawa, Yuji, Dave, Kanan, Barczyszyn, Karin, Lima, Karol Sartori, Secombe, Kate, White, Kate, Cooper, Kate, Katsura, Kouji, Biggs, Karen, Ciarrocca, Katharine, Dennis, Kristopher, Tomizuka, Ken, Hendler, Kevin, Komo, Ikuko, Skallsjö, Kristina, Hodgins, Kristy, Rupel, Katia, Tanaka, Keiko, Kurup, Seema, Gueiros, Luiz, Agatti, Larissa, Garzona-Navas, Laura, Guerra, Letícia, Portela, Leila, Iossi, Leilani, Elting, Linda, Baad-Hansen, Lene, Reeder, Leslie, Lang, Leticia, Menezes, Liciane, Braun, Liliana, Grando, Liliane, Lim, Mathew, Fernandez, Lina, McKeage, Lucy, Campos, Luana, Simonato, Luciana, Muniz, Luciana, van Draanen, Leah, Mizutani, Mieko, Huang, Tsai-Wei, Riad, Mahfujul, Nazar, Mahnoor, Souza, Maíra, Minamisako, Mariana, Pereira, Manoela, Mantelato, Carlos, Diniz-Freitas, Márcio, Montezuma, Marco, Andrade, Marco, Santos, Marcos, Gobbo, Margherita, Fortuna, Maria Caterina, Vitor, Mariana, Marinho, Joana, Markova, Alina, Knuchel, Marlyse, Carlesimo, Marta, Neves, Marta, Mazar, Andrew, Gomez Amarilla, Maria Cristina, Chambers, Mark, Araujo, Melissa de, Melo, Alexandre, Cole, Melody, Elsayed, Mohamed, Fliedner, Monica, Hauer-Jensen, Martin, Bouchacourt, Micaela, Brennan, Michael, Thirlwell, Michael, Nakamura, Michio, Nakagaki, Midori, Rossi, Camila, Miller, Robert, Kaprilian, Mireille, Kase, Michael, Dougan, Michael, Stokman, Monique, Monsen, Ragnhild, Morgan, Alisha, Harding, Jocelyn, Taleghani, Maryam, Genot, Marie-Therese, Seshadri, Mukund, Muzyka, Brian, Batista, Nancy, Gadd, Nancy, Tanda, Naoko, Nasr, Narmin, Garcia, Natália, Lee, Nathan, Palmier, Natalia, Brito-Dellan, Norman, Corbitt, Nancy, Pieralisi, Neli, Serrano, Verônica, Iacovelli, Nicola Alessandro, Blijlevens, Nicole, Sampaio, Norma Lúcia, Karra, Nour, Venkatesh, Niveditha, Yarom, Noam, Borin, Renata Cristina, Lemenchick, Olivia, Mendes, Ondina, Nicolatou-Galitis, Ourania, Shchitka, Vasiliy, Bossi, Paolo, Reis, Paula, Santos, Paulo Sérgio, Fernandez-Ortega, Paz, Parker, Ira, García, Raquel, Fritz, Peter, Peters, Edmund, Gardner, Pamela, Girons, Pierre Saint, Tiwari, Priya, Chaturvedi, Pravin, de Moraes, Tais, Andrade, Priscila, Nair, Raj, Gibson, Rachel, Gururaj, Rachita, Abdalla-Aslan, Ragda, Thota, Raghu, Lalla, Rajesh, Mendes, Rui Amaral, Prado, Raquel Almeida, Ongole, Ravikiran, Taybos, George, Mackey, Regina, Rego, Renata, Camilotti, Renata, Ferrari, Renata, Junior, Renato, Bensadoun, Rene-Jean, Logan, Richard, Sales, Roberta, Zanicotti, Roberta, Tunes, Roberta, Mauceri, Rodolfo, Feitoza, Rosiene, Ruddy, Kathryn, Rybczyk, Cynthia, Trager, Stephanie, Mitsunaga, Sachiyo, Gunathilake, Sahani, Saini, Rajan, Salvestrini, Viola, Mukhopadhyay, Sandip, Angeloz, Sandrina, Sankar S, Pramod, Barbosa, Luciana S Barbosa, Volkova, Elena, Elad, Sharon, Cantoreggi, Sergio, Gordon, Sharon, Brown, Shelly, Janine Tam, Shu Yie, Faleiro, Sibelle, da Silva, Silmara, de Oliveira, Silvia, Jensen, Siri Beier, Skrinjar, Ivana, Beaumont, Sophie, Sperandio, Felipe, Reese, Sandra, Roser, Steven, Seo, Sachiko, van Leeuwen, Stephanie, Sonis, Stephen, Bernard, Stephen, Samuel, Stephen Rajan, Taylor, Stuart, Maitra, Suranjan, Skulski, Susanne, Carlisle, Suzanne, Avon, Sylvie Louise, Yokota, Tomoya, Yurikusa, Takashi, Polvora, Tabata Santos, Kelock, Tabitha, Fernandes, Tauana, Wain, Taylor, Brown, Timothy, Tetsuhito konishi, Ferreira, Thalyta Amanda, Kataoka, Tomoko, Kelly, Thomas, Mori, Takehiko, Higuchi, Tomoko, Saeki, Toshiaki, Tsoukalas, Nikolaos, De Vandeul, Typhaine Maupoint, Usubuchi, Masatoshi, Lacerda, Vanessa, Tilly, Vanessa, Vigarios, Emmanuelle, Villa, Alessandro, Torregrossa, Vinicius, Selvaraj, Vinodh Kumar, Sarmento, Viviane, Heng, Vivien, Gomes-Silva, Wagner, Kandwal, Abhishek, Wilberg, Petter, Miranda e Silva, Wanessa, I'zzah Wan Mohamad Zain, Wan Nor, Park, Wonse, Tissing, Wim, Soga, Yoshihiko, Van Sebille, Bella, Matsuda, Yuhei, Zadik, Yehuda, Cao, Katrina, Cheung, Yin Ting, Fregnani, Eduardo Rodrigues, Van Sebille, Ysabella, Kauark-Fontes, Elisa, McCurdy-Franks, Emma, Finkelstein, Joel, McCarvell, Victoria, Amaral Mendes, Rui, Speksnijder, Caroline Margina, and Wardill, Hannah Rose

Published
2024
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6. MASCC/ISOO expert opinion on the management of oral problems in patients with advanced cancer

Author

Jones, Jac A., Chavarri-Guerra, Yanin, Corrêa, Luisa Barreto Costa, Dean, David R., Epstein, Joel B., Fregnani, Eduardo R., Lee, Jiyeon, Matsuda, Yuhei, Mercadante, Valeria, Monsen, Ragnhild Elisabeth, Rajimakers, Natasja J. H., Saunders, Deborah, Soto-Perez-de-Celis, Enrique, Sousa, Mariana S., Tonkaboni, Arghavan, Vissink, Arjan, Yeoh, Keng Soon, and Davies, Andrew N.

Published
2022
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11. Mitigating jaw osteonecrosis: bioactive glass and pericardial membrane combination in a rat model

Author

Pellicano, Alexandre Antonio, primary, Benites, Bernar M., additional, Paschoa, Amanda F. N., additional, Oliveira, Laura C., additional, Campos, Ana Carolina P., additional, Martins, Daniel O., additional, Real, Caroline C., additional, de Paula Faria, Daniele, additional, Fonseca, Felipe P., additional, Martinez, Raquel R. C., additional, Pagano, Rosana L., additional, and Fregnani, Eduardo R., additional

Published
2024
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12. Central odontogenic fibroma: an international multicentric study of 62 cases

Author

Roza, Ana Luiza Oliveira Corrêa, Sousa, Emanuel Mendes, Leite, Amanda Almeida, Amaral-Silva, Gleyson Kleber, Morais, Thayná Melo de Lima, Wagner, Vivian Petersen, Schuch, Lauren Frenzel, Vasconcelos, Ana Carolina Uchoa, de Arruda, José Alcides Almeida, Mesquita, Ricardo Alves, Fonseca, Felipe Paiva, Abrahão, Aline Corrêa, Agostini, Michelle, de Andrade, Bruno Augusto Benevenuto, da Silveira, Ericka Janine Dantas, Martínez-Flores, René, Rondanelli, Benjamin Martínez, Alberdi-Navarro, Javier, Robinson, Liam, Marin, Constanza, Assunção Júnior, José Narciso Rosa, Valiati, Renato, Fregnani, Eduardo Rodrigues, Santos-Silva, Alan Roger, Lopes, Marcio Ajudarte, Hunter, Keith D., Khurram, Syed Ali, Speight, Paul M., Mosqueda-Taylor, Adalberto, van Heerden, Willie F.P., Carlos, Román, Wright, John M., de Almeida, Oslei Paes, Romañach, Mário José, and Vargas, Pablo Agustin

Published
2021
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13. Oral Lichen Planus and the Lichenoid Group of Diseases

Author

Fonseca, Felipe Paiva, Brennan, Peter A., Gomez, Ricardo Santiago, Pontes, Hélder Antônio Rebelo, Fregnani, Eduardo Rodrigues, Lopes, Márcio Ajudarte, Vargas, Pablo Agustin, Kazi, Rehan, Series Editor, Dwivedi, Raghav C., Series Editor, Brennan, Peter A., editor, and Aldridge, Tom, editor

Published
2019
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19. Longitudinal analysis at three oral sites links oral microbiota to clinical outcomes in allogeneic hematopoietic stem-cell transplant

Author

Heidrich, Vitor, primary, Knebel, Franciele H., additional, Bruno, Julia S., additional, de Molla, Vinícius C., additional, Miranda-Silva, Wanessa, additional, Asprino, Paula F., additional, Tucunduva, Luciana, additional, Rocha, Vanderson, additional, Novis, Yana, additional, Fregnani, Eduardo R., additional, Arrais-Rodrigues, Celso, additional, and Camargo, Anamaria A., additional

Published
2023
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20. Photobiomodulation therapy in management of cancer therapy-induced side effects

Author

Robijns, Jolien, Nair, Raj G., Lodewijckx, Joy, Arany, Praveen, Barasch, Andrei, Bjordal, Jan Magnus, Bossi, Paolo, Chilles, Anne, Corby, Patricia M., Epstein, Joel B., Elad, Sharon, Fekrazad, Reza, Fregnani, Eduardo Rodrigues, Genot, Marie-Thérèse, Ibarra, Ana M. C., Hamblin, Michael R., Heiskanen, Vladimir, Hu, Ken, Klastersky, Jean, Lalla, Rajesh, Latifian, Sofia, Maiya, Arun, Mebis, Jeroen, Migliorati, Cesar A., Milstein, Dan M. J., Murphy, Barbara, Raber-Durlacher, Judith E., Roseboom, Hendrik J., Sonis, Stephen, Treister, Nathaniel, Zadik, Yehuda, Bensadoun, René-Jean, ROBIJNS, Jolien, LODEWIJCKX, Joy, Arany, Praveen, Barasch, Andrei, Jan, Bjordal, Bossi, Paolo, Chilles, Anne, Corby, Patricia, Epstein, Joel, Elad, Sharon, Fekrazad, Reza, Fregnani, Eduardo, Genot, Marie-Thérèse, Ibarra, Ana, Hamblin, Michael, Heiskanen, Vladimir, Hu, Ken, Klastersky, Jean, Lalla, Raj, Latifian, Sofia, Maiya, Arun, MEBIS, Jeroen, Migliorati, Cesar, Milstein, Dan, Murhpy, Barbara, Raber-Durlacher, Judith, Roseboom, Hendrik, Sonis, Stephen, Treister, Nathaniel, Zadik, Yehuda, and Bensadoun, René-Jean

Subjects
cancer supportive care, cancer-treatment side effects, dermatitis, guidelines, mucositis, photobiomodulation (PBM), recommendations, Cancer Research, Oncology, SDG 3 - Good Health and Well-being
Abstract

DisclaimerThis article is based on recommendations from the 12th WALT Congress, Nice, October 3-6, 2018, and a follow-up review of the existing data and the clinical observations of an international multidisciplinary panel of clinicians and researchers with expertise in the area of supportive care in cancer and/or PBM clinical application and dosimetry. This article is informational in nature. As with all clinical materials, this paper should be used with a clear understanding that continued research and practice could result in new insights and recommendations. The review reflects the collective opinion and, as such, does not necessarily represent the opinion of any individual author. In no event shall the authors be liable for any decision made or action taken in reliance on the proposed protocols.ObjectiveThis position paper reviews the potential prophylactic and therapeutic effects of photobiomodulation (PBM) on side effects of cancer therapy, including chemotherapy (CT), radiation therapy (RT), and hematopoietic stem cell transplantation (HSCT).BackgroundThere is a considerable body of evidence supporting the efficacy of PBM for preventing oral mucositis (OM) in patients undergoing RT for head and neck cancer (HNC), CT, or HSCT. This could enhance patients’ quality of life, adherence to the prescribed cancer therapy, and treatment outcomes while reducing the cost of cancer care.MethodsA literature review on PBM effectiveness and dosimetry considerations for managing certain complications of cancer therapy were conducted. A systematic review was conducted when numerous randomized controlled trials were available. Results were presented and discussed at an international consensus meeting at the World Association of photobiomoduLation Therapy (WALT) meeting in 2018 that included world expert oncologists, radiation oncologists, oral oncologists, and oral medicine professionals, physicists, engineers, and oncology researchers. The potential mechanism of action of PBM and evidence of PBM efficacy through reported outcomes for individual indications were assessed.ResultsThere is a large body of evidence demonstrating the efficacy of PBM for preventing OM in certain cancer patient populations, as recently outlined by the Multinational Association for Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO). Building on these, the WALT group outlines evidence and prescribed PBM treatment parameters for prophylactic and therapeutic use in supportive care for radiodermatitis, dysphagia, xerostomia, dysgeusia, trismus, mucosal and bone necrosis, lymphedema, hand-foot syndrome, alopecia, oral and dermatologic chronic graft-versus-host disease, voice/speech alterations, peripheral neuropathy, and late fibrosis amongst cancer survivors.ConclusionsThere is robust evidence for using PBM to prevent and treat a broad range of complications in cancer care. Specific clinical practice guidelines or evidence-based expert consensus recommendations are provided. These recommendations are aimed at improving the clinical utilization of PBM therapy in supportive cancer care and promoting research in this field. It is anticipated these guidelines will be revised periodically.

Published
2022

27. Longitudinal analysis at three oral sites links oral microbiota to clinical outcomes in allogeneic hematopoietic stem-cell transplant

Author

Heidrich, Vitor, primary, Knebel, Franciele H., additional, Bruno, Julia S., additional, de Molla, Vinícius C., additional, Miranda-Silva, Wanessa, additional, Asprino, Paula F., additional, Tucunduva, Luciana, additional, Rocha, Vanderson, additional, Novis, Yana, additional, Fregnani, Eduardo R., additional, Arrais-Rodrigues, Celso, additional, and Camargo, Anamaria A., additional

Published
2022
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32. Evaluation of halitosis parameters in patients undergoing head and neck radiotherapy.

Author

Maluf, Gustavo Valerio, Caldas, Rogério Jardim, Fregnani, Eduardo Rodrigues, Antunes, Héliton Spindola, Tobias, Matheus Augusto Siscotto, and da Silva Santos, Paulo Sérgio

Subjects
SULFUR compounds, STATISTICS, HYDROGEN sulfide, CROSS-sectional method, HEAD & neck cancer, FISHER exact test, MANN Whitney U Test, GAS chromatography, BAD breath, XEROSTOMIA, DATA analysis
Abstract

Objectives: To assess halitosis parameters using OralChroma™ and the correlation with salivary flow, oral hygiene index, radiation dose, and tongue‐coating index among irradiated head and neck cancer patients compared to patients without cancer. Materials and Methods: This cross‐sectional study enrolled irradiated and non‐irradiated patients divided into two groups. Hydrogen sulfide, methyl mercaptan, and dimethyl sulfide (DMS) levels were measured using a gas chromatograph, and sialometry was performed. The tongue‐coating index and simplified oral hygiene index were also assessed. Results: Thirty‐eight patients were allocated to each group. Volatile sulfur compound levels were above the thresholds in both groups. Non‐irradiated individuals showed higher levels of hydrogen sulfide and dimethyl sulfide. Patients with asialia had an inexpressive tongue‐coating index and increased dimethyl sulfide levels. A decrease in salivary flow rate was followed by a significant increase in volatile sulfur compound levels. Higher doses of radiation to the submandibular salivary glands were associated with higher concentrations of sulfide and methyl mercaptan. Conclusions: Head and neck radiotherapy may be important in the development of halitosis. Irradiated patients with asialia presented insignificant lingual biofilm. Consequently, lower levels of volatile sulfur compounds were detected in this group. Asialia, a severe radiation‐induced hyposalivation, impacted the levels of DMS (extraoral origin). [ABSTRACT FROM AUTHOR]

Published
2023
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33. Oral shedding of herpesviruses and clinical outcomes in hematopoietic stem cell transplant patients.

Author

Miranda‐Silva, Wanessa, de Molla, Vinícius Campos, Knebel, Franciele Hinterholz, Tozetto‐Mendoza, Tania Regina, Arrais‐Rodrigues, Celso, Camargo, Anamaria Aranha, Braz‐Silva, Paulo Henrique, and Fregnani, Eduardo Rodrigues

Subjects
ORAL microbiology, EVALUATION of medical care, VIRAL physiology, CYTOMEGALOVIRUSES, PATIENTS, DESCRIPTIVE statistics, EPSTEIN-Barr virus, RESEARCH funding, HERPESVIRUSES, HEMATOPOIETIC stem cell transplantation, POLYMERASE chain reaction, TRANSPLANTATION of organs, tissues, etc.
Abstract

Objectives: To characterize the oral shedding of herpes viruses in patients who underwent allogeneic hematopoietic stem cell transplantation (alloHSCT) and investigate its relationship with clinical outcomes. Materials and Methods: Polymerase chain reaction and enzymatic digestion were performed to identify the oral shedding of the members of the Herpesviridae family in 31 patients. The samples were collected from the oral cavity at five timestamps. Results: The presence of each herpesvirus in the oral cavity was observed in 3.2%, 12.9%, 19.3%, 32.2%, 54.8% and 93.5% patients for human herpesvirus (HHV)‐6A, herpes simplex virus‐1, HHV‐6B, cytomegalovirus (CMV), Epstein–Barr virus (EBV) and HHV‐7, respectively. Oral shedding of herpes virus was not uncommon after alloHSCT. There was a statistically significant association between the EBV and CMV oral shedding at C1 and the cumulative incidence of acute graft‐versus‐host disease (aGVHD). The results suggested that the presence of HSV‐1 at C2 was related to a relapse. The HHV‐7 oral shedding at C2 suggests a possible link between relapse, progression‐free survival and overall survival of the patients. Conclusions: Patients who developed aGVHD showed higher CMV and EBV shedding in the oral cavity at aplasia, suggesting modifications to the pattern of immune cell response and inflammatory microenvironment. [ABSTRACT FROM AUTHOR]

Published
2023
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37. ORAL MICROBIOME INFLUENCES THE CLINICAL COURSE OF ORAL MUCOSITIS IN ALLOGENEIC HSCT PATIENTS

Author

Bruno, Julia S., primary, Heidrich, Vitor, additional, Knebel, Franciele H., additional, De Molla, Vinícius C., additional, Miranda-Silva, Wanessa, additional, Asprino, Paula F., additional, Tucunduva, Luciana, additional, Rocha, Vanderson, additional, Novis, Yana, additional, Arrais-Rodrigues, Celso, additional, Camargo, Anamaria A., additional, and Fregnani, Eduardo R., additional

Published
2022
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39. Commensal Oral Microbiota Influences Ulcerative Oral Mucositis Clinical Course in Allogeneic Stem Cell Transplant Recipients

Author

Bruno, Julia, primary, Heidrich, Vitor, additional, Knebel, Franciele H., additional, de Molla, Vinícius Campos, additional, Parahyba, Claudia Joffily, additional, Miranda-Silva, Wanessa, additional, Asprino, Paula Fontes, additional, Tucunduva, Luciana, additional, Rocha, Vanderson, additional, Novis, Yana, additional, Arrais-Rodrigues, Celso, additional, Camargo, Anamaria Aranha, additional, and Fregnani, Eduardo Rodrigues, additional

Published
2022
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43. Avaliação epidemiologica de 8.875 diagnosticos histopatologicos orais realizados pelo Serviço de Diagnostico Oral da Disciplina de Patologia Bucal da FOP/UNICAMP em um periodo de 32 anos

Author

Fregnani, Eduardo Rodrigues, Vargas, Pablo Agustin, 1973, Villalba, Halbert, Lopes, Márcio Ajudarte, Universidade Estadual de Campinas. Faculdade de Odontologia de Piracicaba, and UNIVERSIDADE ESTADUAL DE CAMPINAS

Subjects
Histopatologia, Boca - Doenças, Epidemiologia, Tumores ontogenicos
Abstract

Orientador : Pablo Agustin Vargas Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba Resumo: Estudos epidemiológicos de doenças orais são importantes para verificar a prevalência relativa de lesões reativas, infecciosas, císticas e neoplásicas e, para determinar estratégias de prevenção e tratamento. A freqüência de lesões orais possui diferenças geográficas, sendo importante obter informações não somente dos países, mas também de suas sub-regiões. Por exemplo, o Brasil possui enormes diferenças econômicas, culturais e demográficas entre suas regiões o que pode refletir em diferentes prevalências de lesões orais. Assim, este trabalho, composto por dois artigos, teve como objetivos: 1- analisar a freqüência dos 8.875 casos de doenças bucais encaminhados ao Serviço de Diagnóstico Oral da FOP/UNICAMP num período de 32 anos; 2- verificar especificamente a freqüência dos Tumores Odontogênicos (TO) no mesmo período. 3- Desenvolver um banco de dados informatizado com a finalidade de agrupar os dados e facilitar a análise da casuística. A metodologia utilizada em comum para os dois artigos consistiu na revisão histológica e revisão dos dados clínicos disponíveis por dois examinadores, lançamentos dos dados no software desenvolvido e posterior estudo epidemiológico. Como resultados do primeiro trabalho, verificou-se que a maioria dos casos foram lesões reativas ou infecciosas tais como hiperplasias fibrosas (26%), lesões periapicais (11%) e periodontites (10%). O carcinoma espinocelular foi responsável por 5% dentre todos os casos e 86% de todas as neoplasias malignas. Paracoccidioidomicose mostrou um grande número de casos (150) e os TO representaram 1,26% do total. Como resultados do segundo trabalho, diagnosticamos 113 casos de TO, sendo 39,4% odontomas, 22,1% ameloblastomas e apenas um caso maligno (Ameloblastoma maligno). Além disso, os TO ocorreram predominantemente entre a 2a e 3a décadas de vida e a região posterior da mandíbula foi o local anatõmico mais acometido para os ameloblastomas e região anterior de maxila para os odontomas Abstract: Epidemiological studies of oral diseases are important to verify the relative prevalence of reactive, infectious, cystic and neoplastic lesions, and to determine strategies of prevention and treatment. Moreover, geographical differences may lead to clues regarding the causes of these lesions. Frequency of oral diseases varies throughout the world, and it is important to have information not only of countries, but also of each specific region. For example, Brazil has enormous differences among its regions relating to economical, cultural and demographic aspects that may reflect different prevalence of oral lesions. So, the purpose of this study, presented as two distinct publications, is to: 1. - show the frequency of 8,875 oral and perioral lesions submitted to the Oral Diagnostic Service of the Oral Pathology Department at the School of Dentistry of Piracicaba - UNICAMP, Brazil during a 32-year period; 2 - to verify particularly the Odontogenic Tumors frequency at the same period of time; 3- a computer database software was developed to collect and store the data. The assessment method consisted of reviewing ali microscopic slides and available clinical data by two examiners; data storage on the developed software and finally, the epidemiological analysis. As a result of the first work, it could be seen that the majority of the oral biopsies were taken from either infectious or reactive lesions as fibrous hyperplasias (26%), periapicallesions (11 %) and periodontitis (10%). Squamous cell carcinoma was responsible for 5% of the total cases and corresponded to 86% of ali malignant neoplasms. It is interesting to notice the occurrence of 150 cases of paracoccidioidomycosis. Odontogenic tumours corresponded to 1.26% of the total. As for the results of the second article, it is noticed that among the 113 Odontogenic Tumors cases, 39.4% were odontomas, 22.1 % ameloblastomas and only one malignant case, diagnosed as malignant Ameloblastoma. In addition, the cases occurred predominantly in the second and third decades of life, and the posterior region of the mandible was the most affected site to ameloblastomas whereas anterior maxilla was to odontomas Mestrado Patologia Mestre em Estomatopatologia

Published
2021

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Author

Amaral-Silva, Gleyson Kleber do, primary, Morais, Thayná Melo de Lima, additional, Wagner, Vivian Petersen, additional, Martins, Manoela Domingues, additional, Fregnani, Eduardo Rodrigues, additional, Soares, Fernando Augusto, additional, Rocha, André Caroli, additional, Pontes, Helder Rabelo, additional, Santos-Silva, Alan Roger, additional, and Vargas, Pablo Agustin, additional

Published
2021
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Author

Heidrich, Vitor, primary, Bruno, Julia S., additional, Knebel, Franciele H., additional, de Molla, Vinícius C., additional, Miranda-Silva, Wanessa, additional, Asprino, Paula F., additional, Tucunduva, Luciana, additional, Rocha, Vanderson, additional, Novis, Yana, additional, Arrais-Rodrigues, Celso, additional, Fregnani, Eduardo R., additional, and Camargo, Anamaria A., additional

Published
2021
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