30 results on '"Freeman, Megan Culler"'
Search Results
2. Gonococcal Infection and Ventriculoperitoneal Shunts
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Freeman, Megan Culler, Lazzara, Alexandra, Lennon, Tyler, McAteer, John, Pease, Matthew, Sefcik, Roberta, Radovic-Stakic, Ana, Milstone, Aaron M., Nowalk, Andrew, and Trent, Maria
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- 2022
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3. Contemporary enterovirus-D68 isolates infect human spinal cord organoids
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Aguglia, Gabrielle, primary, Coyne, Carolyn B., additional, Dermody, Terence S., additional, Williams, John V., additional, and Freeman, Megan Culler, additional
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- 2023
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4. Clinical progress note: Enterovirus D68 and acute flaccid myelitis.
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Lu, Elise, Sinha, Amit, and Freeman, Megan Culler
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- 2023
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5. Setting the Stage for the Next Great Vaccine Success Story
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Freeman, Megan Culler, primary
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- 2022
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6. Performance of the Sofia SARS-CoV-2 Rapid Antigen Test in Symptomatic and Asymptomatic Pediatric Patients
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Freeman, Megan Culler, primary, Freeman, Tanner J, additional, Iagnemma, Jennifer, additional, Rasmussen, Jayne, additional, Heidenreich, Kelly, additional, Wells, Alan, additional, Hoberman, Alejandro, additional, and Mitchell, Stephanie L, additional
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- 2022
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7. Asthma as a risk factor for hospitalization in children with COVID‐19: A nested case‐control study
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Gaietto, Kristina, primary, Freeman, Megan Culler, additional, DiCicco, Leigh Anne, additional, Rauenswinter, Sherry, additional, Squire, Joseph R., additional, Aldewereld, Zachary, additional, Iagnemma, Jennifer, additional, Campfield, Brian T., additional, Wolfson, David, additional, Kazmerski, Traci M., additional, and Forno, Erick, additional
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- 2021
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8. False-Positive Rates in Pediatric SARS-CoV-2 Serology Testing
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Henry, Brandon Michael, primary, Benoit, Stefanie W, additional, Lippi, Giuseppe, additional, Sabalza, Maite, additional, Venkataraman, Iswariya, additional, Geisler, Daniel, additional, Freeman, Megan Culler, additional, Rapsinski, Glenn J, additional, and Wheeler, Sarah E, additional
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- 2021
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9. Respiratory and intestinal epithelial cells exhibit differential susceptibility and innate immune responses to contemporary EV-D68 isolates
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Freeman, Megan Culler, primary, Wells, Alexandra I, additional, Ciomperlik-Patton, Jessica, additional, Myerburg, Michael M, additional, Yang, Liheng, additional, Konopka-Anstadt, Jennifer, additional, and Coyne, Carolyn B, additional
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- 2021
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10. #13: Respiratory and Intestinal Epithelial Cells Exhibit Differential Susceptibility and Innate Immune Responses to Contemporary EV-D68 Isolates
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Freeman, Megan Culler, primary, Wells, Alexandra I, additional, Ciomperlik-Patton, Jessica, additional, Myerburg, Michael M, additional, Anstadt, Jennifer, additional, and Coyne, Carolyn B, additional
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- 2021
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11. Author response: Respiratory and intestinal epithelial cells exhibit differential susceptibility and innate immune responses to contemporary EV-D68 isolates
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Freeman, Megan Culler, primary, Wells, Alexandra I, additional, Ciomperlik-Patton, Jessica, additional, Myerburg, Michael M, additional, Yang, Liheng, additional, Konopka-Anstadt, Jennifer, additional, and Coyne, Carolyn B, additional
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- 2021
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12. Unexpected False-Positive Rates in Pediatric SARS-CoV-2 Serology Using the EUROIMMUN Anti-SARS-CoV-2 ELISA IgG Assay
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Geisler, Daniel, primary, Freeman, Megan Culler, additional, Rapsinski, Glenn J, additional, and Wheeler, Sarah E, additional
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- 2021
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13. A Comprehensive Clinical Description of Pediatric SARS-CoV-2 Infection in Western Pennsylvania
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Freeman, Megan Culler, primary, Gaietto, Kristina, additional, DiCicco, Leigh Anne, additional, Rauenswinter, Sherry, additional, Squire, Joseph R, additional, Aldewereld, Zachary, additional, Rapsinski, Glenn, additional, Iagnemma, Jennifer, additional, Campfield, Brian T., additional, Wolfson, David, additional, Kazmerski, Traci M., additional, and Forno, Erick, additional
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- 2020
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14. Immunocompromised Seroprevalence and Course of Illness of SARS-CoV-2 in One Pediatric Quaternary Care Center
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Freeman, Megan Culler, primary, Rapsinski, Glenn J, additional, Zilla, Megan L, additional, and Wheeler, Sarah E, additional
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- 2020
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15. A man was reinfected with coronavirus after recovery – what does this mean for immunity?
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Freeman, Megan Culler
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Infection -- Health aspects ,Coronaviruses -- Health aspects ,News, opinion and commentary - Abstract
(The Conversation is an independent and nonprofit source of news, analysis and commentary from academic experts.) https://theconversation.com/profiles/megan-culler-freeman-1095575, https://theconversation.com/institutions/university-of-pittsburgh-854 (THE CONVERSATION) A 33-year old man was found to have https://www.statnews.com/2020/08/24/first-covid-19-reinfection-documented-in-hong-kong-researchers-say/ some [...]
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- 2020
16. Asthma as a risk factor for hospitalization in children with COVID‐19: A nested case‐control study.
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Gaietto, Kristina, Freeman, Megan Culler, DiCicco, Leigh Anne, Rauenswinter, Sherry, Squire, Joseph R., Aldewereld, Zachary, Iagnemma, Jennifer, Campfield, Brian T., Wolfson, David, Kazmerski, Traci M., Forno, Erick, and Kalayci, Ömer
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WHEEZE , *COVID-19 , *ASTHMA in children , *CASE-control method , *ASTHMA , *DISEASE exacerbation - Abstract
Background: Most pediatric studies of asthma and COVID‐19 to date have been ecological, which offer limited insight. We evaluated the association between asthma and COVID‐19 at an individual level. Methods: Using data from prospective clinical registries, we conducted a nested case‐control study comparing three groups: children with COVID‐19 and underlying asthma ("A+C" cases); children with COVID‐19 without underlying disease ("C+" controls); and children with asthma without COVID‐19 ("A+" controls). Results: The cohort included 142 A+C cases, 1110 C+ controls, and 140 A+ controls. A+C cases were more likely than C+ controls to present with dyspnea and wheezing, to receive pharmacologic treatment including systemic steroids (all p <.01), and to be hospitalized (4.9% vs. 1.7%, p =.01). In the adjusted analysis, A+C cases were nearly 4 times more likely to be hospitalized than C+ controls (adjusted OR = 3.95 [95%CI = 1.4–10.9]); however, length of stay and respiratory support level did not differ between groups. Among A+C cases, 8.5% presented with an asthma exacerbation and another 6.3% developed acute exacerbation symptoms shortly after testing positive for SARS‐CoV‐2. Compared to historic A+ controls, A+C cases had less severe asthma, were less likely to be on controller medications, and had better asthma symptom control (all p <.01). Conclusions: In our cohort, asthma was a risk factor for hospitalization in children with COVID‐19, but not for worse COVID‐19 outcomes. SARS‐CoV‐2 does not seem to be a strong trigger for pediatric asthma exacerbations. Asthma severity was not associated with higher risk of COVID‐19. [ABSTRACT FROM AUTHOR]
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- 2022
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17. Neonatal Toxic Shock Syndrome–Like Exanthematous Disease in North America
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Freeman, Megan Culler, primary, Mitchell, Stephanie, additional, Ibrahim, John, additional, and Williams, John V, additional
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- 2019
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18. Immunocompromised Seroprevalence and Course of Illness of SARS-CoV-2 in One Pediatric Quaternary Care Center.
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Freeman, Megan Culler, Rapsinski, Glenn J, Zilla, Megan L, and Wheeler, Sarah E
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RESEARCH , *SEROPREVALENCE , *DISEASE progression , *REVERSE transcriptase polymerase chain reaction , *COVID-19 , *BONE marrow transplantation , *INFLAMMATORY bowel diseases , *IMMUNOGLOBULINS , *CONFIDENCE intervals , *IMMUNOCOMPROMISED patients , *CHILDREN'S hospitals , *CROSS-sectional method , *IMMUNE response , *STATISTICAL sampling , *POLYMERASE chain reaction , *IMMUNOCOMPETENT cells , *TRANSPLANTATION of organs, tissues, etc. - Abstract
Background The burden of coronavirus disease 2019 (COVID-19) is poorly understood in pediatric patients due to frequent asymptomatic and mild presentations. Additionally, the disease prevalence in pediatric immunocompromised patients remains unknown. Methods This cross-sectional study tested convenience samples from pediatric patients who had clinically indicated lab work collected and an immunocompromising condition, including oncologic diagnoses, solid organ transplant (SOT), bone marrow transplant, primary immunodeficiency, and rheumatologic conditions or inflammatory bowel disease on systemic immunosuppression, for the presence of antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Results We tested sera from 485 children and observed SARS-CoV-2 seroprevalence of 1.0% (Confidence Interval [CI] 95%: 0.3%–2.4%). Two patients were positive by nasopharyngeal (NP) swab Reverse transcriptase polymerase chain reaction (RT-PCR), but only 1 seroconverted. Patients with oncologic diagnoses or SOT were most likely to be tested for COVID-19 when presenting with respiratory illness as compared with other groups. Conclusions Seroprevalence of antibodies to SARS-CoV-2 in immunocompromised children was similar to that of an immunocompetent pediatric population (0.6%, CI 95%: 0.3%–1.1%), suggesting an adequate antibody response. However, none of the patients who tested positive for antibodies or via NP RT-PCR had more than a mild illness course and 2 patients did not have any reported illness, suggesting that SARS-CoV-2 may not cause a worse clinical outcome in immunosuppressed children, in contrast to immunocompromised adults. [ABSTRACT FROM AUTHOR]
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- 2021
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19. False-Positive Rates in Pediatric SARS-CoV-2 Serology Testing.
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Henry, Brandon Michael, Benoit, Stefanie W, Lippi, Giuseppe, Sabalza, Maite, Venkataraman, Iswariya, Geisler, Daniel, Freeman, Megan Culler, Rapsinski, Glenn J, and Wheeler, Sarah E
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COVID-19 ,SARS-CoV-2 ,MULTISYSTEM inflammatory syndrome in children ,VIRAL antibodies ,COVID-19 testing - Abstract
: Biological, Clinical, and Technical Considerations These considerations are important when performing serology studies, with anti-S1/S2 serology tests preferably used to assess true seroprevalence; anti-RBD-specific serology immunoassays may be better suited to reflecting the presence of neutralizing antibodies. We read with interest the report by Geisler et al[1] and commend the authors for their efforts to address the important need to evaluate the clinical performance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) diagnostic assays in pediatric populations, especially with respect to serology, given the noted differences in immune responses between children and adults.[2] We do feel, however, that the title of this paper may be misleading. This behavior would make it challenging to define whether anti-RBD antibodies are false negatives or if anti-S1 antibodies are false positives. [Extracted from the article]
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- 2022
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20. Emerging arboviruses and implications for pediatric transplantation: A review
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Freeman, Megan Culler, primary, Coyne, Carolyn B., additional, Green, Michael, additional, Williams, John V., additional, and Silva, Laurie A., additional
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- 2018
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21. Chapter 264 - Coronaviruses
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Freeman, Megan Culler and Denison, Mark R.
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- 2016
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22. Colaboradores
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Abzug, Mark J., Adams, David R., Adelson, Stewart L., Aiken, John J., Akay, Begum, Akdis, Cezmi A., Alessandrini, Evaline A., Alexander, Michael A., Ali, Omar, Ambalavanan, Namasivayam, Anderson, Karl E., Anderson, Peter M., Anthony, Kelly K., Antoon, Alia Y., Apkon, Susan D., Ardoin, Stacy P., Ardura, Monica I., Ariss, Michelle M., Armangué, Thaís, Arndt, Carola A.S., Arnon, Stephen S., Aronoff, Stephen C., Asher, David M., Ashworth, Ann, Asselin, Barbara L., Ater, Joann L., Augustine, Erika F., Augustyn, Marilyn C., Avner, Ellis D., Bacino, Carlos A., Baldassano, Robert N., Baldwin, Keith D., Bales, Christina, Balistreri, William F., Baltimore, Robert S., Balwani, Manisha, Barron, Christine E., Barron, Karyl S., Bass, Dorsey M., Batshaw, Mark L., Bauer, Nerissa S., Bayer, Michelle L., Behrman, Richard E., Bell, Michael J., Belmont, John W., Benjamin, Daniel K., Jr., Bennett, Michael J., Benseler, Susanne M., Bernstein, Daniel, Bhutta, Zulfiqar Ahmed, Blanchard, Samra S., Blatter, Joshua A., Bleyer, Archie, Boas, Steven R., Bockting, Walter O., Boerkoel, Neal F., Bogdanovic, Natalija, Boguniewicz, Mark, Bonthius, Daniel J., Bordini, Brett J., Boyer, Kenneth M., Brandow, Amanda M., Branski, David, Breault, David T., Britt, William J., Bryan, Angela R., Buckley, Rebecca H., Budek, Cynthia Etzler, Buescher, E. Stephen, Bunyavanich, Supinda, Burnham, Carey-Ann D., Burstein, Gale R., Bustinduy, Amaya L., Cabada, Miguel M., Caglar, Derya, Cairo, Mitchell S., Camarda, Lauren E., Camitta, Bruce M., Campbell, Angela J.P., Carlo, Waldemar A., Carrigan, Robert B., Caserta, Mary T., Casey, Denise, Chadwick, Ellen Gould, Chamberlain, Lisa J., Chapman, Jennifer I., Cheifetz, Ira M., Chemaitilly, Wassim, Chen, Yuan-Tsong, Chesney, Russell W., Chiriboga, Jennifer A., Chiu, Yvonne E., Cho, Christine B., Christensen, Robert D., Chu, Andrew, Chusid, Michael J., Cieslak, Col. Theodore J., Clark, Jeff A., Cleary, Thomas G., Clemens, John David, Coates, Bria M., Coates, Thomas D., Cohen, Joanna S., Cohen, Mitchell B., Cohen-Wolkowiez, Michael, Colbert, Robert A., Cole, F. Sessions, III, Colombo, John L., Congeni, Joseph A., Conroy, Christine M., Cooper, Amber R., Covar, Ronina A., Crowe, James E., Jr., Czinn, Steve J., Dalmau, Josep O., Darville, Toni, Daum, Robert S., Davidson, Loren T., Davidson, Richard S., Davies, H. Dele, Daw, Najat C., Dayan, Peter S., DeBaun, Michael R., DeMaso, David R., Denison, Mark R., Dent, Arlene E., Desnick, Robert J., deVeber, Gabrielle A., Dhawan, Anil, Dick, André A.S., Dickey, Brianne Z., Dietz, Harry C., III, Donoghue, Lydia J., Donohoue, Patricia A., Donovan, Mary K., Dormans, John P., Dougherty, Kelly A., Doyle, Alexander, Doyle, Daniel A., Doyle, Jefferson J., Drayna, Patrick C., Dreskin, Stephen C., Drolet, Beth A., Dror, Yigal, Dubowitz, Howard, Dumler, J. Stephen, Duncan, Aubrey N., Duncan, Janet, Duncan, Paula M., Dvergsten, Jeffrey A., Earing, Michael G., Eberly, Matthew D., Edgerton, Elizabeth A., Egan, Marie E., Elder, Jack S., Elfenbein, Dianne S., Eppes, Stephen C., Ericson, Jessica, Fasano, Alessio, Feigelman, Susan, Felice, Marianne E., Felner, Eric I., Fels, Edward C., Felsch, Kora N., Ferkol, Thomas W., Jr., Ficicioglu, Can H., Finder, Jonathan D., Fiorino, Kristin N., Fischer, Philip R., Flood, Veronica H., Flynn, Patricia M., Forman, Joel A., Frank, Michael M., Freedman, Melvin H., Freeman, Megan Culler, Frei-Jones, Melissa J., Friedman, Deborah, Friehling, Erika, Frush, Donald P., Gaensbauer, James T., Gahagan, Sheila, Gahl, William A., Galbraith, Sheila S., Gallentine, William B., Gardiner, Paula M., Garibaldi, Luigi R., Gauthier, Gregory M., Gibson, K. Michael, Gibson, Mark, Gigliotti, Francis, Gilliam, Walter S., Ginde, Salil, Ginsburg, Charles M., Girotto, John A., Giulino-Roth, Lisa, Glascoe, Frances Page, Goodman, Denise M., Gopnik, Alison, Gordon, Leslie B., Gorelick, Marc H., Gould, Jane M., Goulet, Olivier, Green, Deanna M., Green, Michael, Green, Thomas P., Greenbaum, Larry A., Griffiths, Anne G., Grimes, Allison, Grindler, Natalia M., Grizzle, Kenneth L., Groleau, Veronique, Grossman, Andrew B., Grossman, David C., Guarino, Alfredo, Gurion, Reut, Hackney, Lisa R., Haddad, Gabriel G., Haddad, Joseph, Jr., Hagan, Joseph F., Jr., Halstead, Scott B., Hammerschlag, Margaret R., Hamvas, Aaron, Hani, Abeer J., Harris, James C., Hartman, Mary E., Haslam, David B., Hassan, H. Hesham Abdel-Kader, Hatzenbuehler, Lindsay A., Hauck, Fern R., Havers, Fiona P., Hecht, Jacqueline T., Heidemann, Sabrina M., Hendley, J. Owen, Henretig, Frederick M., Heresi, Gloria P., Hershey, Andrew D., Herzog, Cynthia E., Hochberg, Jessica, Hoefgen, Holly R., Holinger, Lauren D., Holland-Hall, Cynthia, Hord, Jeffrey D., Horn, B. David, Horstmann, Helen M., Horton, William A., Hotez, Peter J., Hsu, Evelyn, Huang, Stephen A., Huddleston, Heather G., Huff, Vicki, Hug, Denise, Hughes, Dennis P.M., Huh, Winston W., Humphrey, Stephen R., Hunstad, David A., Hunt, Carl E., Hunter, Anna K., Huppert, Stacey S., Ibeziako, Patricia I., Ibrahim, Samar H., Jacobs, Richard F., Jatlaoui, Tara, Jensen, M. Kyle, Jenson, Hal B., John, Chandy C., John, Collin C., Johnston, Michael V., Johnston, Richard B., Jr., Jones, Bridgette L., Jones, James F., Joselow, Marsha, Jospe, Nicholas, Joyce, Joel C., Juern, Anna M., Kabbouche, Marielle A., Kaljee, Linda, Kamat, Deepak, Kansra, Alvina R., Kaplan, Sheldon L., Karlin, Aaron M., Kastner, Daniel L., Katz, Emily R., Kazura, James W., Keane, Virginia A., Kearns, Gregory L., Keesecker, Sarah E., Kelly, Desmond P., Kelly, Kevin J., Kelly, Matthew S., Kelsen, Judith R., Kemper, Kathi J., Kennedy, Melissa, Kerem, Eitan, Kerschner, Joseph E., Khan, Seema, Kim, Jennifer S., King, Charles H., Kinsman, Stephen L., Kirton, Adam, Kishnani, Priya S., Kitts, Robert L., Kleiman, Martin B., Klein, Bruce L., Klein, Bruce S., Klein, Michael D., Kliegman, Robert M., Koch, William C., Kochanek, Patrick M., Kodish, Eric, Kohlhoff, Stephan A., Kostic, Mark A., Krach, Linda E., Krane, Elliot J., Krause, Peter J., Kreipe, Richard E., Krug, Steven E., Kuttesch, John F., Jr., Kwon, Jennifer M., Lachenauer, Catherine S., Ladisch, Stephan, LaFranchi, Stephen H., Lakser, Oren J., Lande, Marc B., Landrigan, Philip J., Landry, Gregory L., Lane, Wendy G., LaRussa, Phillip S., Lawrence, J. Todd R., Lee, Brendan, Lee, K. Jane, Leeder, J. Steven, Lehman, Rebecca K., Lentze, Michael J., Lerner, Norma B., Lestrud, Steven O., Leung, Donald Y.M., Liacouras, Chris A., Liebig, Christopher W., Lindquist, Timothy P., Liu, Andrew H., Lo, Stanley F., Locatelli, Franco, Lockhart, John H., Long, Sarah S., Lopez, Anna Lena, Lossef, Steven V., Lowry, Jennifer A., MacZura, Nora T., Mahajan, Prashant V., Maheshwari, Akhil, Majzoub, Joseph A., Maqbool, Asim, Maranich, Ashley M., Marin, Mona, Marini, Joan C., Markello, Thomas C., Markowitz, Morri, Marks, Kevin P., Maroushek, Stacene R., Martin, Kari L., Mason, Wilbert H., Jr., Mastropietro, Christopher, Matalon, Kimberlee M., Matalon, Reuben K., Mathew, Roshni, Matthews, Dennis J., Mazor, Robert L., McCabe, Megan E., McColley, Susanna A., McGovern, Margaret M., McLean, Heather S., McLeod, Rima, McMahon, Mary A., Mejias, Asuncion, Melby, Peter C., Menchise, Alexandra N., Merritt, Diane F., Mezoff, Ethan A., Michaels, Marian G., Mikati, Mohamad A., Milgrom, Henry, Miller, E. Kathryn, Mink, Jonathan W., Mistovich, R. Justin, Mitchell, Grant A., Morgan-DeWitt, Esi, Moscicki, Anna-Barbara, Moseley, Lovern R., Moughan, Beth, Murphy, James R., Murphy, Kevin P., Murphy, Timothy F., Murray, Thomas S., Myers, René P., Natale, Mindo J., Neal, William A., Nelson, Maureen R., Ness, Jayne M., Neville, Kathleen A., Nevin, Mary A., Newburger, Jane W., Newburger, Peter E., Nield, Linda S., Niermeyer, Susan, Noah, Zehava L., Nogee, Lawrence M., Norris, Robert L., Nowak-Wȩgrzyn, Anna, Obaro, Stephen K., Obeid, Makram M., O’ Brien, Hope L., Ochoa, Theresa J., Ohls, Robin K., Okwo-Bele, Jean-Marie, Oldham, Keith T., Oleszek, Joyce L., Olitsky, Scott E., Olsson, John M., Ombrello, Amanda K., Orenstein, Susan R., Orenstein, Walter A., Osorio, Marisa, Toole, Patrick O’, Owens, Judith A., Özen, Seza, Packman, Charles H., Pais, Priya, Palermo, Tonya M., Pan, Cynthia G., Pappas, Diane E., Parks, Elizabeth P., Parks, John S., Patterson, Maria Jevitz, Peters, Timothy R., Pickering, Larry K., Pless, Misha L., Plummer, Laura S., Pollard, Andrew J., Porter, Craig C., Preciado, Diego, Price, David T., Prober, Charles G., Pruitt, David W., Quan, Linda, Quint, Elisabeth H., Rabinovich, C. Egla, Raffini, Leslie J., Ramilo, Octavio, Ramirez-Montealegre, Denia, Rashid, Asma, Raviola, Giuseppe J., Raymond, Gerald V., Reed, Ann M., Rekate, Harold L., Reller, Megan E., Reyes, Jorges D., Rezvani, Geoffrey A., Rezvani, Iraj, Ritchey, A. Kim, Rivara, Frederick P., Robilotti, Elizabeth V., Robinson, Angela Byun, Roosevelt, Genie E., Rosenberg, David R., Rosenblatt, David S., Roskind, Cindy Ganis, Ross, A. Catharine, Rotar, Mary M., Rozenfeld, Ranna A., Ryan, Colleen A., Sachdev, H.P.S., Sachdeva, Ramesh C., Sadarangani, Manish, Sadun, Rebecca E., Sahin, Mustafa, Salata, Robert A., Salerno, Denise A., Salvana, Edsel Maurice T., Sampson, Hugh A., Sandora, Thomas J., Sandritter, Tracy L., Sankar, Wudbhav N., Sarkissian, Eric J., Sarnaik, Ajit A., Sarnaik, Ashok P., Sarnat, Harvey B., Sarwal, Minnie M., Schanberg, Laura E., Schleiss, Mark R., Schor, Nina F., Schroeder, Bill J., Schroeder, James W., Jr., Schuster, Mark A., Schutze, Gordon E., Scott, Daryl A., Scott, J. Paul, Seed, Patrick C., Segel, George B., Seidman, Ernest G., Serwint, Janet R., Shah, Dheeraj, Shaikhkhalil, Ala, Shamir, Raanan, Shane, Andi L., Shapiro, Bruce K., Shaw, Amanda N., Shaywitz, Bennett A., Shaywitz, Sally E., Sherman, Philip M., Shneider, Benjamin L., Shulman, Stanford T., Sicherer, Scott H., Sills, Richard, Simms, Mark D., Simões, Eric A.F., Simonsen, Kari A., Slavotinek, Anne, Slovis, Thomas L., Smith, P. Brian, Son, Mary Beth F., Sosinsky, Laura Stout, Spahn, Joseph D., Spalter, Rivkie, Sperling, Mark A., Spicer, Robert L., Spiegel, David A., Spoudeas, Helen, Spranger, Jürgen W., Squires, James E., Sreedharan, Rajasree, Sreedharan, Raman, Srinivas, Nivedita, Stager, Margaret M., Stahl, Erin D., Stallings, Amy P., Stallings, Virginia A., Stambough, Kathryn C., Stanberry, Lawrence R., Stanley, Charles A., Stanton, Bonita F., Starke, Jeffrey R., Stechenberg, Barbara W., Steinbach, William J., Stewart, Janet, Stoll, Barbara J., Storch, Gregory A., Strauss, Ronald G., Sucato, Gina S., Suchy, Frederick J., Svoren, Britta M., Swanson, Stephen J., Szilagyi, Moira, Tan, Libo, Tanz, Robert R., Tarek, Nidale, Tifft, Cynthia J., Tinanoff, Norman, Todd, James K., Tompkins, Lucy S., Tower, Richard L., II, Trieu, Michael L., Troncone, Riccardo, Tubergen, David G., Turk, Margaret A., Turner, David A., Ullrich, Christina, Urion, David K., Vanderbilt, Douglas, Vanderhoof, Jon A., Van Hare, George F., van Ingen, Jakko, Van Mater, Heather A., van Soolingen, Dick, VanTubbergen, Christine, Van Why, Scott K., Velardi, Andrea, Vichinsky, Elliott P., Vickery, Brian P., Vitola, Bernadette E., Voynow, Judith A., Waggoner-Fountain, Linda A., Waguespack, Steven G., Walker, David M., Walkovich, Kelly J., Wallihan, Rebecca, Walter, Heather J., Wang, Julie, Ware, Stephanie M., Weese-Mayer, Debra E., Weinberg, Jason B., Weise, Kathryn L., Weiss, Pamela F., Weisse, Martin E., Wells, Lawrence, Wen, Jessica W., Wendel, Danielle, Werlin, Steven L., Wessels, Michael R., Wetmore, Ralph F., Wetzel, Randall C., Wexler, Isaiah D., Wharff, Elizabeth A., White, A. Clinton, Jr., White, Perrin C., Williams, John V., Willoughby, Rodney E., Jr., Wilschanski, Michael, Wilson, Pamela, Wilson, Samantha L., Winell, Jennifer J., Winnie, Glenna B., Winter, Harland S., Wise, Paul H., Wolf, Joshua, Wolfe, Joanne, Wood, James B., Worth, Laura L., Wright, Joseph L., Wright, Terry W., Wu, Eveline Y., Yagupsky, Pablo, Yaron, Michael, Yogev, Ram, Yu, JiaDe, Yudkoff, Marc, Zage, Peter E., Zakhour, Ramia, Zeltzer, Lonnie K., Zimmer, Klaus-Peter, Zoran, Naama, and Zuckerman, Barry S.
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- 2018
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23. Invasive Fungal Disease in Acute Leukemia: Single Center Retrospective Study
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England, James, primary, Torabi, Sahar, additional, Freeman, Megan Culler, additional, Thomas, Lora, additional, and Satyanarayana, Gowri, additional
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- 2016
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24. Coronaviruses Induce Entry-Independent, Continuous Macropinocytosis
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Freeman, Megan Culler, primary, Peek, Christopher T., additional, Becker, Michelle M., additional, Smith, Everett Clinton, additional, and Denison, Mark R., additional
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- 2014
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25. Coronavirus Replicase-Reporter Fusions Provide Quantitative Analysis of Replication and Replication Complex Formation
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Freeman, Megan Culler, primary, Graham, Rachel L., additional, Lu, Xiaotao, additional, Peek, Christopher T., additional, and Denison, Mark R., additional
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- 2014
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26. Colaboradores
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Abzug, Mark J., Adams, David R., Adelson, Stewart L., Aiken, John J., Akay, Begum, Akdis, Cezmi A., Alessandrini, Evaline A., Alexander, Michael A., Ali, Omar, Ambalavanan, Namasivayam, Anderson, Karl E., Anderson, Peter M., Anthony, Kelly K., Antoon, Alia Y., Apkon, Susan D., Ardoin, Stacy P., Ardura, Monica I., Ariss, Michelle M., Armangué, Thaís, Arndt, Carola A.S., Arnon, Stephen S., Aronoff, Stephen C., Asher, David M., Ashworth, Ann, Asselin, Barbara L., Ater, Joann L., Augustine, Erika F., Augustyn, Marilyn C., Avner, Ellis D., Bacino, Carlos A., Baldassano, Robert N., Baldwin, Keith D., Bales, Christina, Balistreri, William F., Baltimore, Robert S., Balwani, Manisha, Barron, Christine E., Barron, Karyl S., Bass, Dorsey M., Batshaw, Mark L., Bauer, Nerissa S., Bayer, Michelle L., Behrman, Richard E., Bell, Michael J., Belmont, John W., Benjamin, Daniel K., Jr., Bennett, Michael J., Benseler, Susanne M., Bernstein, Daniel, Bhutta, Zulfiqar Ahmed, Blanchard, Samra S., Blatter, Joshua A., Bleyer, Archie, Boas, Steven R., Bockting, Walter O., Boerkoel, Neal F., Bogdanovic, Natalija, Boguniewicz, Mark, Bonthius, Daniel J., Bordini, Brett J., Boyer, Kenneth M., Brandow, Amanda M., Branski, David, Breault, David T., Britt, William J., Bryan, Angela R., Buckley, Rebecca H., Budek, Cynthia Etzler, Buescher, E. Stephen, Bunyavanich, Supinda, Burnham, Carey-Ann D., Burstein, Gale R., Bustinduy, Amaya L., Cabada, Miguel M., Caglar, Derya, Cairo, Mitchell S., Camarda, Lauren E., Camitta, Bruce M., Campbell, Angela J.P., Carlo, Waldemar A., Carrigan, Robert B., Caserta, Mary T., Casey, Denise, Chadwick, Ellen Gould, Chamberlain, Lisa J., Chapman, Jennifer I., Cheifetz, Ira M., Chemaitilly, Wassim, Chen, Yuan-Tsong, Chesney, Russell W., Chiriboga, Jennifer A., Chiu, Yvonne E., Cho, Christine B., Christensen, Robert D., Chu, Andrew, Chusid, Michael J., Cieslak, Col. Theodore J., Clark, Jeff A., Cleary, Thomas G., Clemens, John David, Coates, Bria M., Coates, Thomas D., Cohen, Joanna S., Cohen, Mitchell B., Cohen-Wolkowiez, Michael, Colbert, Robert A., Cole, F. Sessions, III, Colombo, John L., Congeni, Joseph A., Conroy, Christine M., Cooper, Amber R., Covar, Ronina A., Crowe, James E., Jr., Czinn, Steve J., Dalmau, Josep O., Darville, Toni, Daum, Robert S., Davidson, Loren T., Davidson, Richard S., Davies, H. Dele, Daw, Najat C., Dayan, Peter S., DeBaun, Michael R., DeMaso, David R., Denison, Mark R., Dent, Arlene E., Desnick, Robert J., deVeber, Gabrielle A., Dhawan, Anil, Dick, André A.S., Dickey, Brianne Z., Dietz, Harry C., III, Donoghue, Lydia J., Donohoue, Patricia A., Donovan, Mary K., Dormans, John P., Dougherty, Kelly A., Doyle, Alexander, Doyle, Daniel A., Doyle, Jefferson J., Drayna, Patrick C., Dreskin, Stephen C., Drolet, Beth A., Dror, Yigal, Dubowitz, Howard, Dumler, J. Stephen, Duncan, Aubrey N., Duncan, Janet, Duncan, Paula M., Dvergsten, Jeffrey A., Earing, Michael G., Eberly, Matthew D., Edgerton, Elizabeth A., Egan, Marie E., Elder, Jack S., Elfenbein, Dianne S., Eppes, Stephen C., Ericson, Jessica, Fasano, Alessio, Feigelman, Susan, Felice, Marianne E., Felner, Eric I., Fels, Edward C., Felsch, Kora N., Ferkol, Thomas W., Jr., Ficicioglu, Can H., Finder, Jonathan D., Fiorino, Kristin N., Fischer, Philip R., Flood, Veronica H., Flynn, Patricia M., Forman, Joel A., Frank, Michael M., Freedman, Melvin H., Freeman, Megan Culler, Frei-Jones, Melissa J., Friedman, Deborah, Friehling, Erika, Frush, Donald P., Gaensbauer, James T., Gahagan, Sheila, Gahl, William A., Galbraith, Sheila S., Gallentine, William B., Gardiner, Paula M., Garibaldi, Luigi R., Gauthier, Gregory M., Gibson, K. Michael, Gibson, Mark, Gigliotti, Francis, Gilliam, Walter S., Ginde, Salil, Ginsburg, Charles M., Girotto, John A., Giulino-Roth, Lisa, Glascoe, Frances Page, Goodman, Denise M., Gopnik, Alison, Gordon, Leslie B., Gorelick, Marc H., Gould, Jane M., Goulet, Olivier, Green, Deanna M., Green, Michael, Green, Thomas P., Greenbaum, Larry A., Griffiths, Anne G., Grimes, Allison, Grindler, Natalia M., Grizzle, Kenneth L., Groleau, Veronique, Grossman, Andrew B., Grossman, David C., Guarino, Alfredo, Gurion, Reut, Hackney, Lisa R., Haddad, Gabriel G., Haddad, Joseph, Jr., Hagan, Joseph F., Jr., Halstead, Scott B., Hammerschlag, Margaret R., Hamvas, Aaron, Hani, Abeer J., Harris, James C., Hartman, Mary E., Haslam, David B., Hassan, H. Hesham Abdel-Kader, Hatzenbuehler, Lindsay A., Hauck, Fern R., Havers, Fiona P., Hecht, Jacqueline T., Heidemann, Sabrina M., Hendley, J. Owen, Henretig, Frederick M., Heresi, Gloria P., Hershey, Andrew D., Herzog, Cynthia E., Hochberg, Jessica, Hoefgen, Holly R., Holinger, Lauren D., Holland-Hall, Cynthia, Hord, Jeffrey D., Horn, B. David, Horstmann, Helen M., Horton, William A., Hotez, Peter J., Hsu, Evelyn, Huang, Stephen A., Huddleston, Heather G., Huff, Vicki, Hug, Denise, Hughes, Dennis P.M., Huh, Winston W., Humphrey, Stephen R., Hunstad, David A., Hunt, Carl E., Hunter, Anna K., Huppert, Stacey S., Ibeziako, Patricia I., Ibrahim, Samar H., Jacobs, Richard F., Jatlaoui, Tara, Jensen, M. Kyle, Jenson, Hal B., John, Chandy C., John, Collin C., Johnston, Michael V., Johnston, Richard B., Jr., Jones, Bridgette L., Jones, James F., Joselow, Marsha, Jospe, Nicholas, Joyce, Joel C., Juern, Anna M., Kabbouche, Marielle A., Kaljee, Linda, Kamat, Deepak, Kansra, Alvina R., Kaplan, Sheldon L., Karlin, Aaron M., Kastner, Daniel L., Katz, Emily R., Kazura, James W., Keane, Virginia A., Kearns, Gregory L., Keesecker, Sarah E., Kelly, Desmond P., Kelly, Kevin J., Kelly, Matthew S., Kelsen, Judith R., Kemper, Kathi J., Kennedy, Melissa, Kerem, Eitan, Kerschner, Joseph E., Khan, Seema, Kim, Jennifer S., King, Charles H., Kinsman, Stephen L., Kirton, Adam, Kishnani, Priya S., Kitts, Robert L., Kleiman, Martin B., Klein, Bruce L., Klein, Bruce S., Klein, Michael D., Kliegman, Robert M., Koch, William C., Kochanek, Patrick M., Kodish, Eric, Kohlhoff, Stephan A., Kostic, Mark A., Krach, Linda E., Krane, Elliot J., Krause, Peter J., Kreipe, Richard E., Krug, Steven E., Kuttesch, John F., Jr., Kwon, Jennifer M., Lachenauer, Catherine S., Ladisch, Stephan, LaFranchi, Stephen H., Lakser, Oren J., Lande, Marc B., Landrigan, Philip J., Landry, Gregory L., Lane, Wendy G., LaRussa, Phillip S., Lawrence, J. Todd R., Lee, Brendan, Lee, K. Jane, Leeder, J. Steven, Lehman, Rebecca K., Lentze, Michael J., Lerner, Norma B., Lestrud, Steven O., Leung, Donald Y.M., Liacouras, Chris A., Liebig, Christopher W., Lindquist, Timothy P., Liu, Andrew H., Lo, Stanley F., Locatelli, Franco, Lockhart, John H., Long, Sarah S., Lopez, Anna Lena, Lossef, Steven V., Lowry, Jennifer A., MacZura, Nora T., Mahajan, Prashant V., Maheshwari, Akhil, Majzoub, Joseph A., Maqbool, Asim, Maranich, Ashley M., Marin, Mona, Marini, Joan C., Markello, Thomas C., Markowitz, Morri, Marks, Kevin P., Maroushek, Stacene R., Martin, Kari L., Mason, Wilbert H., Jr., Mastropietro, Christopher, Matalon, Kimberlee M., Matalon, Reuben K., Mathew, Roshni, Matthews, Dennis J., Mazor, Robert L., McCabe, Megan E., McColley, Susanna A., McGovern, Margaret M., McLean, Heather S., McLeod, Rima, McMahon, Mary A., Mejias, Asuncion, Melby, Peter C., Menchise, Alexandra N., Merritt, Diane F., Mezoff, Ethan A., Michaels, Marian G., Mikati, Mohamad A., Milgrom, Henry, Miller, E. Kathryn, Mink, Jonathan W., Mistovich, R. Justin, Mitchell, Grant A., Morgan-DeWitt, Esi, Moscicki, Anna-Barbara, Moseley, Lovern R., Moughan, Beth, Murphy, James R., Murphy, Kevin P., Murphy, Timothy F., Murray, Thomas S., Myers, René P., Natale, Mindo J., Neal, William A., Nelson, Maureen R., Ness, Jayne M., Neville, Kathleen A., Nevin, Mary A., Newburger, Jane W., Newburger, Peter E., Nield, Linda S., Niermeyer, Susan, Noah, Zehava L., Nogee, Lawrence M., Norris, Robert L., Nowak-Wȩgrzyn, Anna, Obaro, Stephen K., Obeid, Makram M., O'Brien, Hope L., Ochoa, Theresa J., Ohls, Robin K., Okwo-Bele, Jean-Marie, Oldham, Keith T., Oleszek, Joyce L., Olitsky, Scott E., Olsson, John M., Ombrello, Amanda K., Orenstein, Susan R., Orenstein, Walter A., Osorio, Marisa, O'Toole, Patrick, Owens, Judith A., Özen, Seza, Packman, Charles H., Pais, Priya, Palermo, Tonya M., Pan, Cynthia G., Pappas, Diane E., Parks, Elizabeth P., Parks, John S., Patterson, Maria Jevitz, Peters, Timothy R., Pickering, Larry K., Pless, Misha L., Plummer, Laura S., Pollard, Andrew J., Porter, Craig C., Preciado, Diego, Price, David T., Prober, Charles G., Pruitt, David W., Quan, Linda, Quint, Elisabeth H., Rabinovich, C. Egla, Raffini, Leslie J., Ramilo, Octavio, Ramirez-Montealegre, Denia, Rashid, Asma, Raviola, Giuseppe J., Raymond, Gerald V., Reed, Ann M., Rekate, Harold L., Reller, Megan E., Reyes, Jorges D., Rezvani, Geoffrey A., Rezvani, Iraj, Ritchey, A. Kim, Rivara, Frederick P., Robilotti, Elizabeth V., Robinson, Angela Byun, Roosevelt, Genie E., Rosenberg, David R., Rosenblatt, David S., Roskind, Cindy Ganis, Ross, A. Catharine, Rotar, Mary M., Rozenfeld, Ranna A., Ryan, Colleen A., Sachdev, H.P.S., Sachdeva, Ramesh C., Sadarangani, Manish, Sadun, Rebecca E., Sahin, Mustafa, Salata, Robert A., Salerno, Denise A., Salvana, Edsel Maurice T., Sampson, Hugh A., Sandora, Thomas J., Sandritter, Tracy L., Sankar, Wudbhav N., Sarkissian, Eric J., Sarnaik, Ajit A., Sarnaik, Ashok P., Sarnat, Harvey B., Sarwal, Minnie M., Schanberg, Laura E., Schleiss, Mark R., Schor, Nina F., Schroeder, Bill J., Schroeder, James W., Jr., Schuster, Mark A., Schutze, Gordon E., Scott, Daryl A., Scott, J. Paul, Seed, Patrick C., Segel, George B., Seidman, Ernest G., Serwint, Janet R., Shah, Dheeraj, Shaikhkhalil, Ala, Shamir, Raanan, Shane, Andi L., Shapiro, Bruce K., Shaw, Amanda N., Shaywitz, Bennett A., Shaywitz, Sally E., Sherman, Philip M., Shneider, Benjamin L., Shulman, Stanford T., Sicherer, Scott H., Sills, Richard, Simms, Mark D., Simões, Eric A.F., Simonsen, Kari A., Slavotinek, Anne, Slovis, Thomas L., Smith, P. Brian, Son, Mary Beth F., Sosinsky, Laura Stout, Spahn, Joseph D., Spalter, Rivkie, Sperling, Mark A., Spicer, Robert L., Spiegel, David A., Spoudeas, Helen, Spranger, Jürgen W., Squires, James E., Sreedharan, Rajasree, Sreedharan, Raman, Srinivas, Nivedita, Stager, Margaret M., Stahl, Erin D., Stallings, Amy P., Stallings, Virginia A., Stambough, Kathryn C., Stanberry, Lawrence R., Stanley, Charles A., Stanton, Bonita F., Starke, Jeffrey R., Stechenberg, Barbara W., Steinbach, William J., Stewart, Janet, Stoll, Barbara J., Storch, Gregory A., Strauss, Ronald G., Sucato, Gina S., Suchy, Frederick J., Svoren, Britta M., Swanson, Stephen J., Szilagyi, Moira, Tan, Libo, Tanz, Robert R., Tarek, Nidale, Tifft, Cynthia J., Tinanoff, Norman, Todd, James K., Tompkins, Lucy S., Tower, Richard L., II, Trieu, Michael L., Troncone, Riccardo, Tubergen, David G., Turk, Margaret A., Turner, David A., Ullrich, Christina, Urion, David K., Vanderbilt, Douglas, Vanderhoof, Jon A., Van Hare, George F., van Ingen, Jakko, Van Mater, Heather A., van Soolingen, Dick, VanTubbergen, Christine, Van Why, Scott K., Velardi, Andrea, Vichinsky, Elliott P., Vickery, Brian P., Vitola, Bernadette E., Voynow, Judith A., Waggoner-Fountain, Linda A., Waguespack, Steven G., Walker, David M., Walkovich, Kelly J., Wallihan, Rebecca, Walter, Heather J., Wang, Julie, Ware, Stephanie M., Weese-Mayer, Debra E., Weinberg, Jason B., Weise, Kathryn L., Weiss, Pamela F., Weisse, Martin E., Wells, Lawrence, Wen, Jessica W., Wendel, Danielle, Werlin, Steven L., Wessels, Michael R., Wetmore, Ralph F., Wetzel, Randall C., Wexler, Isaiah D., Wharff, Elizabeth A., White, A. Clinton, Jr., White, Perrin C., Williams, John V., Willoughby, Rodney E., Jr., Wilschanski, Michael, Wilson, Pamela, Wilson, Samantha L., Winell, Jennifer J., Winnie, Glenna B., Winter, Harland S., Wise, Paul H., Wolf, Joshua, Wolfe, Joanne, Wood, James B., Worth, Laura L., Wright, Joseph L., Wright, Terry W., Wu, Eveline Y., Yagupsky, Pablo, Yaron, Michael, Yogev, Ram, Yu, JiaDe, Yudkoff, Marc, Zage, Peter E., Zakhour, Ramia, Zeltzer, Lonnie K., Zimmer, Klaus-Peter, Zoran, Naama, and Zuckerman, Barry S.
- Published
- 2016
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27. Neonatal Toxic Shock Syndrome–Like Exanthematous Disease in North America.
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Freeman, Megan Culler, Mitchell, Stephanie, Ibrahim, John, and Williams, John V
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C-reactive protein , *FEVER , *NEONATAL intensive care , *NEONATAL intensive care units , *THROMBOCYTOPENIA , *TOXIC shock syndrome - Abstract
Neonatal toxic shock syndrome (TSS)-like exanthematous disease (NTED) is a syndrome first reported in Japan. Neonates develop systemic exanthema, thrombocytopenia, and fever usually during the first week of life. The disease is distinguished from frank TSS because affected infants are not severely ill and do not meet TSS criteria. Most infants are confirmed to be colonized with TSST-1 producing strains of S. aureus. Suggested diagnostic criteria for NTED include a skin rash with generalized macular erythema and one of the following symptoms: fever >38.0°C, thrombocytopenia <150 x103uL, or low positive C-reactive protein (1-5 mg/dL) in the absence of another known disease process. NTED is common in Japanese NICUs, but outside Japan, only one case has been reported in France. We describe the first case of NTED reported in North America. [ABSTRACT FROM AUTHOR]
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- 2021
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28. Emerging arboviruses and implications for pediatric transplantation: A review.
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Freeman, Megan Culler, Coyne, Carolyn B., Green, Michael, Williams, John V., and Silva, Laurie A.
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ARBOVIRUS diseases , *VIRUS diseases , *ARBOVIRUSES , *GRAFT rejection , *CHIKUNGUNYA virus , *DENGUE viruses , *TRANSPLANTATION of organs, tissues, etc. - Abstract
Recent years have brought a rise in newly emergent viral infections, primarily in the form of previously known arthropod‐transmitted viruses that have increased significantly in both incidence and geographical range. Of particular note are DENV, CHIKV, and ZIKV, which are transmitted mostly by Aedes species of mosquitoes that exhibit a wide and increasing global distribution. Being important pathogens for the general population, these viruses have the potential to be devastating in the international transplant community, with graft rejection and death as possible outcomes of infection. In this review, we discuss the current state of knowledge for these viruses as well as repercussions of infection in the solid organ and HSCT population, with a focus, when possible, on pediatric patients. [ABSTRACT FROM AUTHOR]
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- 2019
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29. Immune cells promote paralytic disease in mice infected with enterovirus D68.
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Woods Acevedo MA, Lan J, Maya S, Jones JE, Williams JV, Freeman MC, and Dermody TS
- Abstract
Enterovirus D68 (EV-D68) is associated with acute flaccid myelitis (AFM), a poliomyelitis-like illness causing paralysis in young children. However, mechanisms of paralysis are unclear, and antiviral therapies are lacking. To better understand EV-D68 disease, we inoculated newborn mice intracranially to assess viral tropism, virulence, and immune responses. Wild-type (WT) mice inoculated intracranially with a neurovirulent strain of EV-D68 showed infection of spinal cord neurons and developed paralysis. Spinal tissue from infected mice revealed increased levels of chemokines, inflammatory monocytes, macrophages, and T cells relative to controls, suggesting that immune cell infiltration influences pathogenesis. To define the contribution of cytokine-mediated immune cell recruitment to disease, we inoculated mice lacking CCR2, a receptor for several EV-D68-upregulated cytokines, or RAG1, which is required for lymphocyte maturation. WT, Ccr2
-/- , and Rag1-/- mice had comparable viral titers in spinal tissue. However, Ccr2-/- and Rag1-/- mice had significantly less paralysis relative to WT mice. Consistent with impaired T cell recruitment to sites of infection in Ccr2-/- and Rag1-/- mice, antibody-mediated depletion of CD4+ or CD8+ T cells from WT mice diminished paralysis. These results indicate that immune cell recruitment to the spinal cord promotes EV-D68-associated paralysis and illuminate new targets for therapeutic intervention.- Published
- 2024
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30. A Comprehensive Clinical Description of Pediatric SARS-CoV-2 Infection in Western Pennsylvania.
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Freeman MC, Gaietto K, DiCicco LA, Rauenswinter S, Squire JR, Aldewereld Z, Rapsinski G, Iagnemma J, Campfield BT, Wolfson D, Kazmerski TM, and Forno E
- Abstract
Objective: We sought to characterize clinical presentation and healthcare utilization for pediatric COVID-19 in Western Pennsylvania (PA)., Methods: We established and analyzed a registry of pediatric COVID-19 in Western PA that includes cases in patients <22 years of age cared for by the pediatric quaternary medical center in the area and its associated pediatric primary care network from March 11 through August 20, 2020., Results: Our cohort included 424 pediatric COVID-19 cases (mean age 12.5 years, 47.4% female); 65% reported exposure and 79% presented with symptoms. The most common initial healthcare contact was through telehealth (45%). Most cases were followed as outpatients, but twenty-two patients (4.5%) were hospitalized: 19 with acute COVID-19 disease, and three for multisystem inflammatory syndrome of children (MIS-C). Admitted patients were younger (p<0.001) and more likely to have pre-existing conditions (p<0.001). Black/Hispanic patients were 5.8 times more likely to be hospitalized than white patients (p=0.012). Five patients (1.2%) were admitted to the PICU, including all three MIS-C cases; two required BiPAP and one mechanical ventilation. All patients survived., Conclusions: We provide a comprehensive snapshot of pediatric COVID-19 disease in an area with low to moderate incidence. In this cohort, COVID-19 was generally a mild disease; however, ~5% of children were hospitalized. Pediatric patients can be critically ill with this infection, including those presenting with MIS-C.
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- 2020
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