24 results on '"Frederick L. Makrauer"'
Search Results
2. Reply
- Author
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Tim Walker, Frederick L. Makrauer, and Vincent Dusabejambo
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Carr ,Hepatology ,Political science ,Gastroenterology ,Global health ,Public administration ,Global Health ,Article - Published
- 2020
3. Single-Cell Analyses of Colon and Blood Reveal Distinct Immune Cell Signatures of Ulcerative Colitis and Crohn’s Disease
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Liza Konnikova, Jessica Toothaker, Rima Fawaz, Jared Silverstein, Randi G. Pleskow, Michael Field, Susanna Huh, Beth-Ann Norton, Sabina Sabharwal, Amit S. Grover, Laurie N. Fishman, Peng Liu, Silvana Bonilla, Rachel W. Winter, Jose Ordovas-Montanes, Alex K. Shalek, Punyanganie S. de Silva, Anne A. Wolf, Jodie Ouahed, Bruce H. Horwitz, Sonia Arora Ballal, Victor L. Fox, Frederick L. Makrauer, Marko Vukovic, Sonia Friedman, Leslie S. Kean, Scott B. Snapper, Sarah Wall, Menno Verhave, Leslie M. Higuchi, Athos Bousvaros, Munir Mobassaleh, Stacy A. Kahn, Collin C. McCourt, Jessica R. Allegretti, Naamah L. Zitomersky, Joshua R. Korzenik, Dennis J. Spencer, Alejandro Flores, Vanessa Mitsialis, Jeff Goldsmith, Lori A. Zimmerman, George C. Tseng, Matthew J. Hamilton, Paul A. Rufo, Brian P. Regan, Tamar Parmet, and Christine K. Lee
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Adult ,Male ,0301 basic medicine ,Adolescent ,Colon ,Regulatory T cell ,Plasmacytoid dendritic cell ,CD38 ,Inflammatory bowel disease ,Peripheral blood mononuclear cell ,Article ,Immunophenotyping ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Immune system ,Crohn Disease ,medicine ,Humans ,RNA-Seq ,Intestinal Mucosa ,Child ,Immunity, Cellular ,Hepatology ,business.industry ,Innate lymphoid cell ,Gastroenterology ,Dendritic cell ,Flow Cytometry ,medicine.disease ,030104 developmental biology ,medicine.anatomical_structure ,Case-Control Studies ,Immunology ,Colitis, Ulcerative ,Female ,030211 gastroenterology & hepatology ,Single-Cell Analysis ,business - Abstract
Background & Aims Studies are needed to determine the mechanisms of mucosal dysregulation in patients with inflammatory bowel diseases (IBDs) and differences in inflammatory responses of patients with ulcerative colitis (UC) vs Crohn’s disease (CD). We used mass cytometry (CyTOF) to characterize and compare immune cell populations in the mucosa and blood from patients with IBD and without IBD (controls) at single-cell resolution. Methods We performed CyTOF analysis of colonic mucosa samples (n = 87) and peripheral blood mononuclear cells (n = 85) from patients with active or inactive UC or CD and controls. We also performed single-cell RNA sequencing, flow cytometry, and RNA in situ hybridization analyses to validate key findings. We used random forest modeling to identify differences in signatures across subject groups. Results Compared with controls, colonic mucosa samples from patients with IBD had increased abundances of HLA-DR+CD38+ T cells, including T-regulatory cells that produce inflammatory cytokines; CXCR3+ plasmablasts; and IL1B+ macrophages and monocytes. Colonic mucosa samples from patients with UC were characterized by expansion of IL17A+ CD161+ effector memory T cells and IL17A+ T-regulatory cells; expansion of HLA-DR+CD56+ granulocytes; and reductions in type 3 innate lymphoid cells. Mucosal samples from patients with active CD were characterized by IL1B+HLA-DR+CD38+ T cells, IL1B+TNF+IFNG+ naive B cells, IL1B+ dendritic cells (DCs), and IL1B+ plasmacytoid DCs. Peripheral blood mononuclear cells from patients with active CD differed from those of active UC in that the peripheral blood mononuclear cells from patients with CD had increased IL1B+ T-regulatory cells, IL1B+ DCs and IL1B+ plasmacytoid DCs, IL1B+ monocytes, and fewer group 1 innate lymphoid cells. Random forest modeling differentiated active UC from active CD in colonic mucosa and blood samples; top discriminating features included many of the cellular populations identified above. Conclusions We used single-cell technologies to identify immune cell populations specific to mucosa and blood samples from patients with active or inactive CD and UC and controls. This information might be used to develop therapies that target specific cell populations in patients with different types of IBD.
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- 2020
4. Factors that Affect Adherence to Surveillance Colonoscopy in Patients with Inflammatory Bowel Disease
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Barbara Farmer, Adam S. Cheifetz, Robert Burakoff, Francis A. Farraye, Peter A. Banks, Sonia Friedman, Leanne N. Torgersen, Frederick L. Makrauer, and Kelly E. Wahl
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medicine.medical_specialty ,Referral ,business.industry ,Colorectal cancer ,Gastroenterology ,Disease ,medicine.disease ,Affect (psychology) ,Inflammatory bowel disease ,Ulcerative colitis ,digestive system diseases ,Dysplasia ,Internal medicine ,medicine ,Immunology and Allergy ,Surveillance colonoscopy ,business - Abstract
BACKGROUND Patients with extensive ulcerative colitis or Crohn's disease of the colon have an increased risk of colon cancer and require colonoscopic surveillance. This study explores factors that affect adherence to surveillance colonoscopy. METHODS Three hundred and seventy-eight patients with ulcerative colitis or Crohn's disease of the colon for at least 7 years and at least one-third of the colon involved participated in this cross-sectional questionnaire study performed at 3 tertiary referral inflammatory bowel disease clinics. RESULTS Two hundred and eight patients were female and 189 had ulcerative colitis. The mean age was 49.9 years and mean disease duration 22.9 years. The total number of surveillance colonoscopies performed was 1529, and the mean number per patient was 4.01. The mean interval between surveillance colonoscopies was 2.71 years; 282 patients had a mean interval of 3-year intervals on average. Significant categories of reasons for nonadherence included logistics, health perceptions, stress, and procedure problems.
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- 2013
5. Global Health Education in Gastroenterology Fellowship: A National Survey
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Frederick L. Makrauer, Ying P Tabak, Pichamol Jirapinyo, Deborah D. Proctor, and Rachel S. Hunt
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Adult ,Male ,medicine.medical_specialty ,Time Factors ,Physiology ,Intrahepatic duct ,Global Health ,Gastroenterology ,Infectious enteritis ,Cholangiocarcinoma ,03 medical and health sciences ,0302 clinical medicine ,Transplant surgery ,Cholelithiasis ,Internal medicine ,Surveys and Questionnaires ,Global health ,medicine ,Humans ,Tuberculosis ,Mesentery ,030212 general & internal medicine ,Fellowships and Scholarships ,Curriculum ,Accreditation ,business.industry ,Survey research ,Middle Aged ,Training Support ,Hepatitis B ,Enteritis ,Hepatitis E ,Bile Ducts, Intrahepatic ,Bile Duct Neoplasms ,Family medicine ,030211 gastroenterology & hepatology ,Female ,business - Abstract
Interest in global health (GH) education is increasing across disciplines. To assess exposure to and perception of GH training among gastroenterology fellows and program directors across the USA. Design: Electronic survey study. Setting: The questionnaire was circulated to accredited US gastroenterology fellowship programs, with the assistance of the American Gastroenterological Association. Participants: Gastroenterology program directors and fellows. The questionnaire was returned by 127 respondents (47 program directors, 78 fellows) from 55 training programs (36 % of all training programs). 61 % of respondents had prior experience in GH. 17 % of programs offered GH curriculum with international elective (13 %), didactic (9 %), and research activity (7 %) being the most common. Fellows had adequate experience managing hepatitis B (93 %), cholangiocarcinoma (84 %), and intrahepatic duct stones (84 %). 74, 69 and 68 % reported having little to no experience managing hepatitis E, tuberculosis mesenteritis, or epidemic infectious enteritis, respectively. Most fellows would participate in an elective in an underserved area locally (81 %) or a 4-week elective abroad (71 %), if available. 44 % of fellows planned on working or volunteering abroad after fellowship. Barriers to establishing GH curriculum included funding (94 %), scheduling (88 %), and a lack of standardized objectives (78 %). Lack of interest, however, was not a concern. Fellows (49 %), more than faculty (29 %) (χ 2 = 21.9; p = 0.03), believed that GH education should be included in fellowship curriculum. Program directors and trainees recognize the importance of GH education. However, only 17 % of ACGME-approved fellowship programs offer the opportunity. Global health curriculum may enhance gastroenterology training.
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- 2016
6. Doctor Message Can Alter Patientsʼ Behavior and Attitudes Regarding Inflammatory Bowel Disease and Colon Cancer
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Frederick L. Makrauer, Robert Burakoff, Francis A. Farraye, Barbara Farmer, Sonia Friedman, Kelly E. Wahl, Peter A. Banks, Leanne N. Torgersen, and Adam S. Cheifetz
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Adult ,Male ,medicine.medical_specialty ,Colorectal cancer ,Cross-sectional study ,Colonoscopy ,Inflammatory bowel disease ,Gastroenterology ,Young Adult ,Crohn Disease ,Quality of life ,Physicians ,Surveys and Questionnaires ,Internal medicine ,medicine ,Humans ,Immunology and Allergy ,Young adult ,Aged ,Aged, 80 and over ,Crohn's disease ,medicine.diagnostic_test ,business.industry ,Middle Aged ,Prognosis ,medicine.disease ,Ulcerative colitis ,digestive system diseases ,Cross-Sectional Studies ,Colonic Neoplasms ,Colitis, Ulcerative ,Female ,business - Abstract
Background: Patients with extensive ulcerative (UC) or Crohn's (CD) colitis have an increased risk of colon cancer and require colonoscopic surveillance. This study explores patient attitudes and behavior regarding inflammatory bowel disease (IBD), colonoscopies, and colon cancer risk. Methods: In all, 514 patients with UC or CD colitis for at least 7 years and at least one-third of the colon involved participated in this cross-sectional questionnaire study performed at three tertiary referral IBD clinics. Results: In all, 288 patients were female, 262 had UC, and 252 had CD. The mean age was 48 (range, 20–88) and mean number of years with symptoms was 20 (range, 7–51); 70.8% reported “my doctor” as an extensive information source. The mean perceived lifetime risk of developing colon cancer without having routine colonoscopies was 56% (SD 24.193). We developed and validated a scale of 10 important messages that IBD patients remember doctors discussing with them (“Doctor Told Scale”). Higher scores correlated with better quality of life (P < 0.001) and positive descriptors of colonoscopies and IBD (P < 0.001). Patients with higher scores perceived a higher chance of getting colon cancer without having surveillance colonoscopies (P < 0.001) and were more likely to report that the correct surveillance interval is every 2 years (P < 0.01). Conclusions: Patients who remember their doctor's messages are more likely to have a positive outlook about colonoscopies and IBD, have a better quality of life, undergo surveillance colonoscopies at the correct interval, and perceive cancer risk more realistically. (Inflamm Bowel Dis 2012)
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- 2012
7. Diverticulosis and Diverticulitis
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Anna M. Duloy and Frederick L Makrauer
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medicine.medical_specialty ,business.industry ,Internal medicine ,medicine ,Diverticulitis ,business ,medicine.disease ,Gastroenterology ,Diverticulosis - Abstract
Diverticular disease has been considered a disease of the elderly, but recently, an increased incidence has been noted in younger patients. Diverticulosis is asymptomatic; however, when symptomatic, it is referred to as diverticular disease. When associated with any inflammation, it is diverticulitis. Diverticulitis is an acute illness, but symptoms may become chronic with recurrent episodes. When mucosal inflammation is present, segmental colitis associated with diverticula (SCAD) is identified. SCAD is a distinct, but uncommon, disorder sharing histological and clinical features of ulcerative colitis and Crohn disease. Only 1 to 2% of patients with diverticulosis will develop diverticulitis. This review covers the epidemiology, etiology and genetics, pathophysiology and pathogenesis, diagnosis, management, complications and prognosis of diverticulosis, and diverticulitis. Figures show diverticulosis, symptomatic uncomplicated diverticular disease, diverticulitis, computed tomography scan of acute diverticulitis, and a management algorithm. Tables list definitions, risk factors, pathophysiology, modified Hinchey classification, and acute diverticulitis differential diagnosis. This review contains 5 highly rendered figures, 5 tables and 105 references
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- 2015
8. Differential Regulation of Peripheral Leukocyte Genes in Patients With Active Crohn's Disease and Crohn's Disease in Remission
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Scott Hande, Choong-Chin Liew, Frederick L. Makrauer, Robert Burakoff, Sonia Friedman, Jun Ma, and Peter A. Banks
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Adult ,Male ,Microarray ,Disease ,Severity of Illness Index ,Inflammatory bowel disease ,Young Adult ,Crohn Disease ,Gene expression ,Leukocytes ,medicine ,Humans ,Gene ,Aged ,Crohn's disease ,Reverse Transcriptase Polymerase Chain Reaction ,business.industry ,Gene Expression Profiling ,Remission Induction ,Gastroenterology ,Middle Aged ,medicine.disease ,Ulcerative colitis ,digestive system diseases ,Gene expression profiling ,Gene Expression Regulation ,Immunology ,Female ,business ,Biomarkers - Abstract
Goals: Assessment of disease severity is a frequent challenge in the management of Crohn's disease. Noninvasive, accurate markers for monitoring disease activity are urgently required. Specific gene expression patterns and molecular biomarkers associated with active Crohn's disease could serve as such markers, thereby providing a novel approach to disease activity monitoring. Background: Gene expression profiling in circulating leukocytes has shown promise in several medical conditions and blood may provide an easily accessible surrogate tissue for using gene expression profiling to assess activity of Crohn's disease. Study: In this study, we compared genome-wide transcription profiles of circulating leukocytes in patients with active and quiescent Crohn's disease. Results: We observed complex changes in blood gene expression patterns in active Crohn's disease: genes of various functional categories were differentially regulated between active and inactive Crohn's disease. We specifically identified a number of inflammatory molecules overexpressed or underexpressed in active Crohn's disease and validated a subset of these genes by real-time reverse transcription-polymerase chain reaction. Conclusions: The genes differentially regulated in peripheral leukocytes represent potential new biomarkers for assessing the activity of Crohn's disease.
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- 2010
9. Blood-based biomarkers used to predict disease activity in Crohn's disease and ulcerative colitis
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Jonathan S. Levine, Robert D. Odze, Sonia Friedman, Joshua R. Korzenik, Matthew J. Hamilton, Hai Choo Smith, Choong-Chin Liew, Cheryl A Adackapara, Louisa Onyewadume, Changming Cheng, Frederick L. Makrauer, Vikas Pabby, Wei Wang, Robert Burakoff, and Samuel Chao
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Male ,medicine.medical_specialty ,Adolescent ,Disease ,Real-Time Polymerase Chain Reaction ,Gastroenterology ,Inflammatory bowel disease ,Severity of Illness Index ,Crohn Disease ,Internal medicine ,Severity of illness ,medicine ,Immunology and Allergy ,Humans ,RNA, Messenger ,Colitis ,Whole blood ,Crohn's disease ,business.industry ,Reverse Transcriptase Polymerase Chain Reaction ,Gene Expression Profiling ,Case-control study ,High-Throughput Nucleotide Sequencing ,medicine.disease ,Prognosis ,Ulcerative colitis ,Case-Control Studies ,Colitis, Ulcerative ,Female ,business ,Biomarkers - Abstract
Background Identifying specific genes that are differentially expressed during inflammatory bowel disease flares may help stratify disease activity. The aim of this study was to identify panels of genes to be able to distinguish disease activity in Crohn's disease (CD) and ulcerative colitis (UC). Methods Patients were grouped into categories based on disease and severity determined by histological grading. Whole blood was collected by PAXgene Blood RNA collection tubes, (PreAnalytiX) and gene expression analysis using messenger RNA was conducted. Logistic regression was performed on multiple combinations of common probe sets, and data were evaluated in terms of discrimination by computing the area under the receiving operator characteristic curve (ROC-AUC). Results Nine inactive CD, 8 mild CD, 10 moderate-to-severe CD, 9 inactive UC, 8 mild UC, 10 moderate-to-severe UC, and 120 controls were hybridized to Affymetrix U133 Plus 2 microarrays. Panels of 6 individual genes discriminated the stages of disease activity: CD with mild severity {ROC-AUC, 0.89 (95% confidence interval [CI], 0.84%-0.95%)}, CD with moderate-to-severe severity (ROC-AUC 0.98 [95% CI, 0.97-1.0]), UC with mild severity (ROC-AUC 0.92 [95% CI, 0.87-0.96]), and UC with moderate-to-severe severity (ROC-AUC 0.99 [95% CI, 0.97-1.0]). Validation by real-time reverse transcription-PCR confirmed the Affymetrix microarray data. Conclusions The specific whole blood gene panels reliably distinguished CD and UC and determined the activity of disease, with high sensitivity and specificity in our cohorts of patients. This simple serological test has the potential to become a biomarker to determine the activity of disease.
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- 2015
10. High self-efficacy predicts adherence to surveillance colonoscopy in inflammatory bowel disease
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Robert Burakoff, Francis A. Farraye, Kelly E. Wahl, Frederick L. Makrauer, Sonia Friedman, Leanne N. Torgersen, Adam S. Cheifetz, Barbara Farmer, and Peter A. Banks
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Adult ,Male ,medicine.medical_specialty ,Referral ,Colorectal cancer ,Population ,Colonoscopy ,Disease ,Logistic regression ,Inflammatory bowel disease ,Gastroenterology ,Health Services Accessibility ,Young Adult ,Crohn Disease ,Risk Factors ,Internal medicine ,Surveys and Questionnaires ,medicine ,Immunology and Allergy ,Humans ,education ,Aged ,Aged, 80 and over ,education.field_of_study ,Motivation ,medicine.diagnostic_test ,business.industry ,Middle Aged ,medicine.disease ,Prognosis ,Ulcerative colitis ,Self Efficacy ,Cross-Sectional Studies ,Health Care Surveys ,Population Surveillance ,Colonic Neoplasms ,Patient Compliance ,Colitis, Ulcerative ,Female ,Self Report ,business ,Follow-Up Studies - Abstract
BACKGROUND Patients with extensive ulcerative colitis or Crohn's disease of the colon have an increased risk of colon cancer and require colonoscopic surveillance. In this study, we assessed individual self-efficacy (SE) to estimate the probability of adherence to surveillance colonoscopies. METHODS Three hundred seventy-eight patients with ulcerative colitis or Crohn's disease of the colon for at least 7 years and with at least one third of the colon involved participated in this cross-sectional questionnaire study performed at 3 tertiary referral inflammatory bowel disease clinics. Medical charts were abstracted for demographic and clinical variables. The questionnaire contained a group of items assessing SE for undergoing colonoscopy. RESULTS We validated our 20-question SE scale and used 8 of the items that highlighted scheduling, preparation, and postprocedure recovery, to develop 2 shorter SE scales. All 3 scales were reliable with Cronbach's α ranging from 0.845 to 0.905 and correlated with chart-documented adherence to surveillance colonoscopy (P < 0.001). We then developed logistic regression models to predict adherence to surveillance colonoscopy using each scale separately along with other key variables (i.e., disease location, knowledge of correct adherence intervals, and information sources of patients consulted regarding Crohn's disease and ulcerative colitis) and demonstrated model accuracy up to 74%. CONCLUSIONS SE, as measured by our validated scales, correlates with chart-adherence to surveillance colonoscopy. Our adherence model, which includes SE, predicts adherence with 74% certainty. An 8-item validated clinical questionnaire can be administered to assess whether patients in this population may require further intervention for adherence.
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- 2014
11. Does Local Irradiation Affect Gastric Emptying in Humans?
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Jeffrey L. Becker, Frederick L. Makrauer, Elizabeth Oates, Jay Shumaker, Timothy O'Connor, Ross A. Abrams, and Richard W. McCallum
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Adult ,Diarrhea ,Male ,medicine.medical_specialty ,Vomiting ,Nausea ,medicine.medical_treatment ,Gastroenterology ,Pelvis ,Neoplasms ,Internal medicine ,Abdomen ,medicine ,Humans ,Aged ,Radiotherapy ,Gastric emptying ,business.industry ,Cancer ,General Medicine ,Middle Aged ,Thorax ,medicine.disease ,Radiation therapy ,medicine.anatomical_structure ,Gastric Emptying ,Case-Control Studies ,Toxicity ,Female ,medicine.symptom ,Complication ,business ,Nuclear medicine - Abstract
The authors measured gastric emptying in 13 patients undergoing radiation therapy to the chest, abdomen, or pelvis for nongastrointestinal cancer to investigate whether gastric emptying (GE) was altered by this therapy. Symptoms and weight were monitored at regular intervals. Patients served as their own controls and were compared to a group of healthy subjects. When studied prior to radiation therapy (baseline), cancer patients had a gastric emptying rate that was similar to a healthy control group (t1/2 mean+/-SEM 92.0+/-15.3 vs. 80.4+/-8.2 min). Irradiation did not change the emptying rate, either after the first dose (early) of 180 cGy (t1/2 99.5+/-17.9) or after 2 weeks of therapy (late) with 3000 cGy (t1/2 75.5+/-7.3). There was no correlation of radiation field or tumor type with gastric emptying rate. Two of the 13 patients experienced nausea and vomiting during their course of radiation, but their gastric emptying was unchanged from baseline.
- Published
- 1999
12. Mo1872 Trough and Antibody Level Testing in Conjunction With the Use of a Standardized Clinical Assessment and Management Plan Does Not Improve Outcomes Among Patients With Inflammatory Bowel Disease
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Frederick L. Makrauer, Dionne A. Graham, Stephanie Cantu, Robert Burakoff, Vikas Pabby, Jeffery O. Greenberg, Peter A. Banks, Edward L. Barnes, Beth-Ann Norton, Punyanganie S. de Silva, Michael Currier, Michal Tomczak, Sarah R. McLaughlin, Aoibhlinn O'Toole, Matthew J. Hamilton, George Ciociolo, Jessica R. Allegretti, Joshua R. Korzenik, Jonathan S. Levine, Sonia Friedman, Karl Laskowski, and Scott B. Snapper
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medicine.medical_specialty ,Hepatology ,business.industry ,Gastroenterology ,medicine ,Physical therapy ,Antibody level ,Intensive care medicine ,Trough (economics) ,business ,medicine.disease ,Inflammatory bowel disease - Published
- 2016
13. Blood-based biomarkers can differentiate ulcerative colitis from Crohn's disease and noninflammatory diarrhea
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Samuel Chao, Robert D. Odze, Choong-Chin Liew, Robert Burakoff, Hema Khurana, Sonia Friedman, Frederick L. Makrauer, Jay Ying, and Molly Perencevich
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Adult ,Diarrhea ,Male ,alpha Karyopherins ,medicine.medical_specialty ,Cell Cycle Proteins ,Inflammatory bowel disease ,Gastroenterology ,Crohn Disease ,Aminohydrolases ,Antigens, CD ,Internal medicine ,medicine ,Immunology and Allergy ,Blood test ,Humans ,Receptors, Interleukin-1 Type II ,Receptors, Immunologic ,Whole blood ,Aged ,Crohn's disease ,medicine.diagnostic_test ,business.industry ,Gene Expression Profiling ,Oxo-Acid-Lyases ,Alpha Karyopherins ,Middle Aged ,medicine.disease ,Ulcerative colitis ,Gene expression profiling ,Cytoskeletal Proteins ,Logistic Models ,ELAV Proteins ,Immunology ,Colitis, Ulcerative ,Female ,medicine.symptom ,business ,Biomarkers ,BH3 Interacting Domain Death Agonist Protein - Abstract
Background: Blood gene expression profiling has been used in several studies to identify patients with a number of conditions and diseases. A blood test with the ability to differentiate Crohn's disease (CD) from ulcerative colitis (UC) and noninflammatory diarrhea would be useful in the clinical management of these diseases. Methods: Affymetrix U133Plus 2.0 GeneChip oligonucleotide arrays were used to generate whole blood gene expression profiles for 21 patients with UC, 24 patients with CD, and 10 control patients with diarrhea, but without colonic pathology. Results: A supervised learning method (logistic regression) was used to identify specific panels of probe sets which were able to discriminate between UC and CD and from controls. The UC panel consisted of the four genes, CD300A, KPNA4, IL1R2, and ELAVL1; the CD panel comprised the four genes CAP1, BID, NIT2, and NPL. These panels clearly differentiated between CD and UC. Conclusions: Gene expression profiles from blood can differentiate patients with CD from those with UC and from noninflammatory diarrheal disorders. (Inflamm Bowel Dis 2011;)
- Published
- 2010
14. Fulminant hepatic failure secondary to erlotinib
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Frederick L. Makrauer, Pasi A. Jänne, Robert D. Odze, Amir A. Qamar, and Weitian Liu
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Oncology ,medicine.medical_specialty ,Lung Neoplasms ,medicine.drug_class ,Administration, Oral ,Tyrosine-kinase inhibitor ,Erlotinib Hydrochloride ,Fulminant hepatic failure ,Internal medicine ,Pancreatic cancer ,Carcinoma, Non-Small-Cell Lung ,medicine ,Carcinoma ,Humans ,heterocyclic compounds ,Epidermal growth factor receptor ,Lung cancer ,neoplasms ,Protein Kinase Inhibitors ,Aged ,Hepatology ,biology ,business.industry ,Liver Neoplasms ,Gastroenterology ,Liver Failure, Acute ,medicine.disease ,respiratory tract diseases ,ErbB Receptors ,biology.protein ,Quinazolines ,Female ,Erlotinib ,business ,medicine.drug - Abstract
Erlotinib is a tyrosine kinase inhibitor recently approved by the Food and Drug Administration for the treatment of non–small-cell lung cancer and pancreatic cancer. We report a case of a patient with stage IV non–small-cell lung cancer who died of fulminant hepatic failure as a result of treatment with erlotinib.
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- 2007
15. Tu1112 Global Health Curriculum in Gastroenterology Fellowship: A National Survey
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Deborah D. Proctor, Ying P. Tabak, Frederick L. Makrauer, Rachel S. Hunt, and Pichamol Jirapinyo
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medicine.medical_specialty ,Medical education ,Hepatology ,business.industry ,Family medicine ,Gastroenterology ,medicine ,Global health ,business ,Curriculum - Published
- 2015
16. Tu1244 Use of a Standardized Clinical Assessment and Management Plan to Demonstrate Barriers to Trough Level and Antibody Level Testing in Patients on Anti-Tumor Necrosis Factor Therapy for Inflammatory Bowel Disease
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Jeffery O. Greenberg, George Ciociolo, Scott B. Snapper, Jonathan S. Levine, Karl Laskowski, Punyanganie S. de Silva, Michael Currier, Sarah R. McLaughlin, Frederick L. Makrauer, Joshua R. Korzenik, Robert Burakoff, Matthew J. Hamilton, Vikas Pabby, Dionne A. Graham, Edward L. Barnes, Beth-Ann Norton, Michal Tomczak, Sonia Friedman, Peter A. Banks, and Roya Ghazinouri
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medicine.medical_specialty ,Hepatology ,business.industry ,General surgery ,Gastroenterology ,Antibody level ,medicine.disease ,Inflammatory bowel disease ,Anti-Tumor Necrosis Factor Therapy ,Physical therapy ,Trough level ,Medicine ,In patient ,business - Abstract
Use of a Standardized Clinical Assessment and Management Plan to Demonstrate Barriers to Trough Level and Antibody Level Testing in Patients on Anti-Tumor Necrosis Factor Therapy for Inflammatory Bowel Disease Edward L. Barnes, Jonathan S. Levine, Vikas Pabby, George Ciociolo, Roya Ghazinouri, Jeffery O. Greenberg, Karl Laskowski, Sarah R. McLaughlin, Dionne Graham, Peter A. Banks, Michael Currier, Punyanganie S. de Silva, Sonia Friedman, Matthew J. Hamilton, Joshua R. Korzenik, Frederick L. Makrauer, Beth-Ann Norton, Scott B. Snapper, Michal Tomczak, Robert Burakoff
- Published
- 2015
17. 5-aminosalicylate therapy is associated with higher 6-thioguanine levels in adults and children with inflammatory bowel disease in remission on 6-mercaptopurine or azathioprine
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Rie Maurer, Noah Wilson-Rich, Peter A. Banks, Anna Zholudev, Sarathchandra I Reddy, Frederick L. Makrauer, Sonia Friedman, Scott Hande, Athos Bousvaros, and Robert Burakoff
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Azathioprine ,Inflammatory bowel disease ,Gastroenterology ,Severity of Illness Index ,Internal medicine ,Severity of illness ,medicine ,Immunology and Allergy ,Humans ,Prospective cohort study ,Child ,Mesalamine ,Thioguanine ,Aged ,Retrospective Studies ,Thiopurine methyltransferase ,biology ,business.industry ,Mercaptopurine ,Anti-Inflammatory Agents, Non-Steroidal ,Remission Induction ,Retrospective cohort study ,Middle Aged ,medicine.disease ,Inflammatory Bowel Diseases ,Ulcerative colitis ,Cross-Sectional Studies ,Treatment Outcome ,Immunology ,biology.protein ,Female ,business ,Biomarkers ,Immunosuppressive Agents ,medicine.drug ,Follow-Up Studies - Abstract
Background Small uncontrolled trials have suggested that 5-aminosalicylate (5-ASA) medications increase 6-thioguanine nucleotide (6-TGn) levels in adults with Crohn's disease (CD) on azathioprine (AZA) or 6-mercaptopurine (6-MP), presumably through the inhibition of thiopurine methyltransferase (TPMT). We tested the theory that coadministration of 5-ASA agents with AZA/6-MP results in higher 6-TGn levels in a large cohort of children and adults with CD or ulcerative colitis (UC). Methods A retrospective cohort study identified all children and adults treated for IBD with AZA/6-MP at 2 tertiary medical centers. Patients were included if their TPMT genotype was known and 6-TGn and 6-methymercaptopurine (6-MMP) levels had been obtained after 3 months of clinical remission at a stable dose of AZA/6-MP. 6-TGn and 6-MMP levels were compared between patients taking and those not taking 5-ASA medications through the use of linear regression models to identify and adjust for potentially confounding variables. Results Of the 126 patients included, 88 were taking 5-ASA medications. Patients on 5-ASA agents had higher mean 6-TGn levels after adjustment for confounding variables (Delta6-TGn, 47.6 +/- 21.8 pmol/8 x 10 red blood cells; P = 0.03). CD and TPMT heterozygosity was independently associated with higher 6-TGn levels (P = 0.01 and P = 0.03, respectively). 5-ASA exposure was not associated with a change in 6-MMP levels. Conclusions We found that 5-ASA therapy is associated with higher 6-TGn levels in children and adults with IBD on 6-MP/AZA. TPMT inhibition may not explain this effect because 5-ASA exposure did not affect 6-MMP levels. The observed association of CD with higher 6-TGn levels is novel and needs to be verified in prospective studies.
- Published
- 2006
18. Lymphocytic Colitis Secondary to Ipilimumab Treatment
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Frederick L. Makrauer, Robert D. Odze, and Alejandro García-Varona
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Lymphocytic colitis ,biology ,business.industry ,Gastroenterology ,Ipilimumab ,medicine.disease ,Antibodies monoclonal ,Immunology ,biology.protein ,Immunology and Allergy ,Medicine ,Colitis ,Antibody ,business ,medicine.drug - Published
- 2013
19. Tu1127 Prevalence and Significance of Ileal Inflamation in Ulcerative Colitis: A Prospective Controlled Study
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Robert D. Odze, Sonia Friedman, Joshi Pallavi, Matthew J. Hamilton, Frederick L. Makrauer, Peter A. Banks, Kevin L. Golden, Shelley Hurwitz, and Li Qing Chen
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medicine.medical_specialty ,Hepatology ,business.industry ,Internal medicine ,Gastroenterology ,medicine ,business ,medicine.disease ,Ulcerative colitis - Published
- 2013
20. Tu1090 Global Health Curriculum Should Be Included in Gastroenterology Fellowship
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Frederick L. Makrauer, Ying P. Tabak, and Graham McMahon
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Medical education ,medicine.medical_specialty ,Hepatology ,business.industry ,Family medicine ,Gastroenterology ,Global health ,Medicine ,business ,Curriculum - Published
- 2012
21. Contributions of vitamin D intake and seasonal sunlight exposure to plasma 25-hydroxyvitamin D concentration in elderly women
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Frederick L. Makrauer, Bess Dawson-Hughes, Gerard E. Dallal, L M Salamone, and D Zantos
- Subjects
Sunlight ,Aged, 80 and over ,Food intake ,medicine.medical_specialty ,Analysis of Variance ,Nutrition and Dietetics ,Chemistry ,Hydroxycholecalciferols ,Medicine (miscellaneous) ,Vitamina d ,Vitamin D intake ,Endocrinology ,Internal medicine ,medicine ,Vitamin D and neurology ,Humans ,Female ,Vitamin D ,Total Vitamin D ,Aged - Abstract
We investigated the contributions (1.00-8.03 micrograms/d, or 40-321 IU/d) of vitamin D intake and seasonal sunlight exposure to plasma 25(OH)D in 59 healthy women aged 70-97 y with a mean total vitamin D intake of 8.58 micrograms/d (343 IU/d). In the summer and winter, each subject had a fasting blood measurement and assessments of vitamin D intake and sunlight exposure. Vitamin D intake was significantly correlated with plasma 25(OH)D in the summer (r = 0.52, P < 0.01) and winter (r = 0.63, P < 0.01). The influence of sunlight exposure measured in the summer on the 25(OH)D concentration was dependent on the vitamin D intake. In subjects with lower vitamin D intakes (1.00-8.03 micrograms/d, or 40-321 IU/d), the wintertime 25(OH)D concentrations of those with low and high sunlight exposure were comparable. In subjects with higher vitamin D intakes (11.15-28.68 micrograms/d, or 446-1147 IU/d), however, the wintertime 25(OH)D concentrations of those with high sunlight exposure were lower than those with lower exposure [63.8 +/- 3.9 and 80.6 +/- 6.7 nmol/L, respectively, P = 0.066; P (intake by exposure interaction) < 0.05]. This suggests that the contribution of vitamin D intake to plasma 25(OH)D concentration may be influenced by sunlight exposure.
- Published
- 1994
22. Duodenal stenosis in chronic pancreatitis
- Author
-
Peter A. Banks, Frederick L. Makrauer, and Donald A. Antonioli
- Subjects
Adult ,Male ,medicine.medical_specialty ,Physiology ,medicine.medical_treatment ,Duodenal stenosis ,Constriction, Pathologic ,Vagotomy ,Gastroenterology ,Pancreatectomy ,Gastrectomy ,Internal medicine ,Abdomen ,Humans ,Medicine ,Duodenal Diseases ,business.industry ,Middle Aged ,medicine.disease ,Pancreaticoduodenectomy ,Pain, Intractable ,Radiography ,Alcoholism ,Stenosis ,Jejunum ,medicine.anatomical_structure ,Pancreatitis ,Duodenum ,Female ,Duodenal Obstruction ,business - Abstract
Persistent duodenal stenosis has been noted as a complication of chronic pancreatitis, but its clinical importance and histologic basis have not been defined. We report three patients with chronic alcoholic pancreatitis who developed duodenal stenosis and intractable abdominal pain. In two patients, the stenosis was caused by severe inflammation of pancreatic tissue within the wall of the duodenum. Pancreaticoduodenectomy resulted in prompt and sustained clinical improvement in both patients. In the third patient, who had mural inflammation in the distal stomach and presumably in the duodenum as well, vagotomy and gastrojejunostomy relieved severe duodenal obstruction but not pain. This study supports the view that duodenal stenosis is caused by severe intramural duodenal inflammation and suggests that a pancreaticoduodenectomy may be required for relief of pain.
- Published
- 1982
23. Gastroscopic removal of a partial denture
- Author
-
Frederick L. Makrauer and John S. Davis
- Subjects
Male ,Adolescent ,business.industry ,Radiodensity ,digestive, oral, and skin physiology ,Stomach ,Dentistry ,Foreign Bodies ,Gastroscopy ,Fiberoptic endoscope ,Medicine ,Denture, Partial, Removable ,Fiber Optic Technology ,Humans ,Space Maintenance, Orthodontic ,medicine.symptom ,business ,General Dentistry ,Confusion - Abstract
A 14-year-old boy accidentally swallowed a partial denture fabricated of radiolucent acrylic material. A young boy accidentally ingested a partial denture. Although the denture was finally extracted easily from the stomach with a fiberoptic endoscope, diagnostic confusion did occur because the denture was made of radiolucent acrylic material. The need for the use of radiopaque denture material is emphasized, and the efficacy of the fiberoptic endoscope in the removal of ingested dental prostheses is outlined.
- Published
- 1977
24. Increased Risk for Vitamin A Toxicity in Severe Hypertriglyceridemia
- Author
-
Frederick L. Makrauer, Ernst J. Schaefer, Robert M. Russell, and Jerome K. Ellis
- Subjects
Vitamin ,medicine.medical_specialty ,Very low-density lipoprotein ,Hyperlipoproteinemia Type V ,chemistry.chemical_compound ,Malabsorption Syndromes ,Internal medicine ,Internal Medicine ,Humans ,Medicine ,Hypervitaminosis A ,Vitamin A ,Triglycerides ,business.industry ,Hypertriglyceridemia ,Retinol ,nutritional and metabolic diseases ,Retinol Equivalent ,General Medicine ,Middle Aged ,medicine.disease ,Hypervitaminosis ,Endocrinology ,chemistry ,Low-density lipoprotein ,Female ,business - Abstract
A 48-year-old woman with malabsorption and type V hyperlipoproteinemia developed hypervitaminosis A with a total plasma vitamin A level of 871 micrograms/dL during therapy with an oral dosage of 18,000 retinol equivalents (60,000 IU) daily. Twelve percent of the total plasma retinol was found to be transported in the chylomicron-very low density lipoprotein (VLDL) fraction, which does not contain retinol-binding protein. For comparison, concentrations of retinyl esters and retinol were determined in nine patients with type V hyperlipoproteinemia and nine control subjects, none of whom were using vitamin A supplements. Both retinyl esters and retinol were significantly elevated in the group with hyperlipoproteinemia (p less than 0.0005 in both cases). Eight of these nine patients had retinol present in the chylomicron-VLDL fraction, whereas retinol was not detectable in this fraction in any of the nine normal controls. The data suggest that patients with severe hypertriglyceridemia associated with type V hyperlipoproteinemia are at increased risk for hypervitaminosis A.
- Published
- 1986
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