31 results on '"Frayne C"'
Search Results
2. Monoclonal TCR-redirected tumor cell killing
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Liddy, Nathaniel, Bossi, Giovanna, Adams, Katherine J., Lissina, Anna, Mahon, Tara M., Hassan, Namir J., Avarret, Jessie G., Bianchi, Frayne C., Pumphrey, Nicholas J., Ladell, Kristin, Gostick, Emma, Lissin, Nikolai M., Harwood, Naomi E., Molloy, Peter E., Li, Yi, Cameron, Brian J., Sami, Malkit, Baston, Emma E., Todorov, Penio T., Dennis, Rebecca E., Harper, Jane V., Dunn, Steve M., Ashfield, Rebecca, Johnson, Andy, McGrath, Yvonne, Plesa, Gabriela, June, Carl H., Kalos, Michael, Price, David A., Williams, Daniel D., Sutton, Deborah H., and Jakobsen, Bent K.
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T cells -- Receptors ,Antigen receptors, T cell -- Research -- Analysis ,Cancer cells -- Research -- Analysis ,Biological sciences ,Health - Abstract
T cell immunity can potentially eradicate malignant cells and lead to clinical remission in a minority of patients with cancer. In the majority of these individuals, however, there is a failure of the specific T cell receptor (TCR)-mediated immune recognition and activation process. Here we describe the engineering and characterization of new reagentstermed immune-mobilizing monoclonal TCRs against cancer (ImmTACs). Four such ImmTACs, each comprising a distinct tumor-associated epitope-specific monoclonal TCR with picomolar affinity fused to a humanized cluster of differentiation 3 (CD3)-specific single-chain antibody fragment (scFv), effectively redirected T cells to kill cancer cells expressing extremely low surface epitope densities. Furthermore, these reagents potently suppressed tumor growth in vivo. Thus, ImmTACs overcome immune tolerance to cancer and represent a new approach to tumor immunotherapy., Harnessing the power of adaptive immunity to combat cancer has been a long-term goal of translational immunotherapy. However, although many avenues in this field have been explored over the past [...]
- Published
- 2012
- Full Text
- View/download PDF
3. Environmental Modification for Cooling, Heating and Potable Water Systems
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Frayne, C., primary
- Published
- 2010
- Full Text
- View/download PDF
4. Alternate-Fueled Combustor-Sector Performance
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Shouse, D. T, Hendricks, R. C, Lynch, A, Frayne, C. W, Stutrud, J. S, Corporan, E, and Hankins, T
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Air Transportation And Safety - Abstract
Alternate aviation fuels for military or commercial use are required to satisfy MIL-DTL-83133F(2008) or ASTM D 7566 (2010) standards, respectively, and are classified as "drop-in" fuel replacements. To satisfy legacy issues, blends to 50% alternate fuel with petroleum fuels are certified individually on the basis of processing and assumed to be feedstock agnostic. Adherence to alternate fuels and fuel blends requires "smart fueling systems" or advanced fuel-flexible systems, including combustors and engines, without significant sacrifice in performance or emissions requirements. This paper provides preliminary performance (Part A) and emissions and particulates (Part B) combustor sector data. The data are for nominal inlet conditions at 225 psia and 800 F (1.551 MPa and 700 K), for synthetic-paraffinic-kerosene- (SPK-) type (Fisher-Tropsch (FT)) fuel and blends with JP-8+100 relative to JP-8+100 as baseline fueling. Assessments are made of the change in combustor efficiency, wall temperatures, emissions, and luminosity with SPK of 0%, 50%, and 100% fueling composition at 3% combustor pressure drop. The performance results (Part A) indicate no quantifiable differences in combustor efficiency, a general trend to lower liner and higher core flow temperatures with increased FT fuel blends. In general, emissions data (Part B) show little differences, but with percent increase in FT-SPK-type fueling, particulate emissions and wall temperatures are less than with baseline JP-8. High-speed photography illustrates both luminosity and combustor dynamic flame characteristics.
- Published
- 2012
5. Alternate-Fueled Combustor-Sector Performance: Part A: Combustor Performance Part B: Combustor Emissions
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Shouse, D. T, Neuroth, C, Henricks, R. C, Lynch, A, Frayne, C, Stutrud, J. S, Corporan, E, and Hankins, T
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Propellants And Fuels - Abstract
Alternate aviation fuels for military or commercial use are required to satisfy MIL-DTL-83133F(2008) or ASTM D 7566 (2010) standards, respectively, and are classified as drop-in fuel replacements. To satisfy legacy issues, blends to 50% alternate fuel with petroleum fuels are certified individually on the basis of feedstock. Adherence to alternate fuels and fuel blends requires smart fueling systems or advanced fuel-flexible systems, including combustors and engines without significant sacrifice in performance or emissions requirements. This paper provides preliminary performance (Part A) and emissions and particulates (Part B) combustor sector data for synthetic-parafinic-kerosene- (SPK-) type fuel and blends with JP-8+100 relative to JP-8+100 as baseline fueling.
- Published
- 2010
6. An economic evaluation of the early impact of Aimhigher: excellence challenge on pre-16 outcomes: update to previous analysis
- Author
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Emmerson, C., Frayne, C., McNally, S., and Silva, O.
- Abstract
The Aimhigher: Excellence Challenge intervention seeks to encourage more young people to articipate in tertiary education. This paper updates previous estimates of the impact of the programme on the GCSE marks and reported expected school leaving ages, among year 11 pupils. Information from 3 different cohorts is used (whereas the previous analysis had data on the first 2 cohorts). In some schools the second and third cohorts have been exposed to the policy, whereas in others only the third cohort was exposed to the policy. This distinction is used to model the impact of the policy using linear regression analysis. However the lack of a comparison group in Spring 2004 means that the impact of the policy can only be estimated under relatively strong assumptions about the evolution of the impact of the policy across time. Under the assumption that the policy had the same impact in the original treatment (EiC Phase 1 & 2 areas) in Spring 2004 as in Spring 2003, we find evidence that being part of the Aimhigher: Excellence Challenge programme in the new areas (EiC Phase 3) has led to a 5.2 percentage point increase in the year 11 pupils expecting to leave education at age 20 or over. Although slightly larger, this estimate is not statistically significantly different from the increase of 3.7 percentage points found in the original (EiC Phase 1 & 2) areas. Across both types of area (EiC Phase 1& 2 and EiC Phase 3) we estimate that the average impact of the policy is to increase the percentage of year 11 pupils reporting that they will leave education at age 20 or above by 4.6 percentage points. We also find some evidence of a similar positive impact on GCSE English results, although the impact across other GCSEs is less clear. While the assumptions made in producing these new estimates are relatively strong it is clear that the analysis of the new data does not contradict the previous estimates (which were reliant on less strong assumptions).
- Published
- 2006
7. Aimhigher: excellence challenge: a policy evaluation using the labour force survey
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Emmerson, C., Frayne, C., McNally, S., and Silva, O.
- Abstract
Over the past decades, an increasing number of young people have entered into higher education in the UK. Yet, despite this growth, the UK still has a low ranking in international comparisons for the rate of participation in post-compulsory education. Furthermore, young people from disadvantaged backgrounds are greatly underrepresented. Aimhigher: Excellence Challenge is one of the government initiatives designed in an attempt to address this problem. The policy was introduced in September 2001 in the same areas as those targeted by the Excellence in Cities (EiC) programme. Its stated aims are to raise aspirations and participation in tertiary education of individuals aged between 14 and 19; a special focus is on the targeting of people with a disadvantaged background. In this paper we study the impact of Aimhigher: Excellence Challenge using information contained in the Labour Force Survey (LFS) for individuals aged between 16 and 20. Individuals in Local Education Authorities (LEA) where the programme was introduced are compared to individuals in LEAs where the policy was not implemented. The difference in average outcomes over time is compared for Aimhigher: Excellence Challenge LEAs and the 'comparison group' of LEAs outside the programme. This 'difference-in-differences' methodology allows us to distinguish the impact of the policy on outcomes from the (time-constant) effect of unobserved LEA attributes and trends common to both groups of LEAs. Yet, given that the policy was implemented in EiC areas, and that there may be complementarities between the two programmes, our results should not be interpreted as isolating the independent effect of the Aimhigher: Excellence Challenge programme. Overall, we find that the policy did not have a positive and statistically significant effect on further/higher education participation rates (and educational attainments) for young individuals. In fact, while point estimates of the impact of Aimhigher: Excellence Challenge suggest a positive impact of the policy on the fraction of young individuals studying beyond compulsory education, there is enormous variation around these estimates and they do not provide (statistically) reliable information on the effectiveness of the policy. This is due to the way in which the policy was implemented to cover only a few (very broadly defined) 'treatment' areas, which have to be compared to a similarly broadly defined comparison group. As a result, there is considerable variation in the outcome variables and only very large policy effects might be expected to result in statistical significance. However, our analysis gives stronger evidence of heterogeneity in the effects of the policy. Individuals from more disadvantaged backgrounds (for example, as indicated by those living on social housing or having unemployed fathers) have seemed to benefit more from the policy, compared to students from better-off backgrounds - their probability of entering post-compulsory education is significantly higher as a result of the policy. However, again, the estimates are relatively sensitive to specification and therefore should be interpreted with some caution.
- Published
- 2006
8. Early quantitative evidence on the impact of the pathways to work pilots
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Adam, S., Emmerson, C., Frayne, C., and Goodman, A.
- Abstract
Since October 2003 the Department for Work and Pensions (DWP) has been piloting reforms in England, Scotland and Wales which provide greater support alongside greater obligations to encourage many new claimants of incapacity benefits to move into paid work. The Pathways to Work package of reforms includes: a series of usually mandatory workfocused interviews; programmes designed to boost claimants' prospects of being able to work; and increased financial incentives for individuals to enter paid employment. As part of a quantitative assessment of the impact of the programme, a telephone survey of those making an initial enquiry to Jobcentre Plus about claiming incapacity benefits was conducted in both pilot and comparison areas before and after the pilots were implemented. This report focuses on the differences in some early quantitative outcomes between Pathways and non-Pathways areas. Two empirical techniques are used to investigate the early impact of the pilots on employment, earnings, receipt of incapacity benefits, and a potential indicator of the extent to which individuals' health affects their everyday activities. The analysis was undertaken by researchers at the Institute for Fiscal Studies and the telephone interviews were undertaken by the National Centre for Social Research. All these findings are preliminary: more comprehensive analysis will be conducted in later stages of the evaluation. This report analyses outcomes at a time shortly after the pilots started. Further analysis of outcomes will assess Pathways to Work using survey and administrative data from a later cohort and will examine outcomes over a longer period of time.
- Published
- 2006
9. Education subsidies and school drop-out rates
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Dearden, L., Emmerson, C., Frayne, C., and Meghir, C.
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I28 ,Abbrecher ,Bildungsfinanzierung ,ddc:330 ,J24 ,H52 ,Subvention - Abstract
This paper evaluates whether means-tested grants paid to secondary students are an effective way of reducing the proportion of school dropouts. We look at this problem using matching techniques on a pilot study carried out in England during 1999 and 2000 using a specially designed dataset that ensures that valid comparisons between our pilot and control areas are made. The impact of the subsidy is quite substantial with initial participation rates (at age 16/17) being around 4.5 percentage points higher. Full-time participation rates one year later are found to have increased by around 6.4 percentage points which is largely due to the EMA having a significant effect on retention in post compulsory education. These effects vary by eligibility group with those receiving the full payment having the largest initial increase in participation, whilst the effects for those who are partially eligible are only significantly different from the control group in the second year of the program. There is some evidence that the participation rate effect is stronger for boys, especially in the second year, and that the policy goes some way to reducing the gap in dropout rates between boys and girls. It is also clear that the policy has the largest impact on children from the poorest socio-economic background.
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- 2005
10. Updating the UK’s code for fiscal stability
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Emmerson, C., Frayne, C., and Love, S.
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JEL classification: E62, H62 - Abstract
The 1998 Code for Fiscal Stability sets out the framework within which UK fiscal policy is now set. While having such a code does not make it easier for a Government to meet its fiscal objectives, it may improve the economic credibility of the policy process. To date the Code has generally worked well, and in any case many of the Treasury’s practices exceed the minimum requirements of the Code. However, improvements could be made in the light of recent experiences. In particular it would be preferable for less emphasis to be placed on the precise forecasts for fiscal aggregates and greater emphasis to be placed on the magnitude of the risks to those forecasts. Using the projections contained in the March 2004 Budget, and information on the size of errors made in the past, we estimate that there is now a 60% chance that the Chancellor’s “golden rule” will be met without further tax increases or spending cuts. This compares to 74% for the forecast made by the Treasury 12 months earlier. As well as clarifying how cautious forecasts are, the uncertainty surrounding projections for fiscal aggregates also has implications for the way in which progress towards any fiscal rules should be interpreted.
- Published
- 2004
11. An examination of the IFS corporation tax forecasting record
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Basu, S., Emmerson, C., and Frayne, C.
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JEL classification: E62, H25, H6. Corporate tax, forecasting ,Steueraufkommen ,H25 ,ddc:330 ,Prognose ,Großbritannien ,Unternehmensbesteuerung ,Prognoseverfahren ,E62 ,H60 ,Corporate Tax ,Forecasting - Abstract
This paper examines the corporation tax forecasting techniques used by the Institute for Fiscal Studies. For current year forecasts a judgemental forecast is found to have performed better than relying solely on a simple model or information on the receipts available so far in the current financial year. For longer time horizons the judgemental forecast has performed slightly less well than the modelled forecast. While forecasts made later in the financial year have led to more accurate estimates of receipts in the current year no evidence is found that this has improved the accuracy of longer run forecasts. In the short term inaccuracies in the modelling process are found to be more important than errors in forecasting growth in corporate profits. However the latter is still an important component of errors and one that grows substantially in relative importance as the forecast horizon increases.
- Published
- 2003
12. Education Maintenance Allowance: the first two years: a quantitative evaluation
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Ashworth, A., Hardman, H., Hartfree, H., Maguire, S., Middleton, S., Smith, D., Dearden, L., Emmerson, C., Frayne, C., and Megir, C.
- Abstract
The Department for Education and Skills (DfES) has commissioned a longitudinal evaluation of the piloting of Education Maintenance Allowances (EMAs). The evaluation is being undertaken by a consortium of research organisations, led by the Centre for Research in Social Policy (CRSP) and also includes the National Centre for Social Research, the Institute for Fiscal Studies (IFS) and the Institute for Employment Research (IER). This is the second report of the statistical evaluation of EMA. The statistical evaluation design is a longitudinal cohort study involving large random sample surveys of young people (and their parents) in 10 EMA pilot areas and eleven control areas1. Two cohorts of young people were selected from Child Benefit records. The first cohort of young people left compulsory schooling in the summer of 1999 and they, and their parents, were interviewed between November 1999 and April 2000. A second interview was carried out with these young people between November 2000 and April 2001. The second cohort left compulsory education the following summer of 2000 and young people, and their parents, were first interviewed between November 2000 and April 2001.
- Published
- 2002
13. Education maintenance allowance: the first year: a quantitative evaluation
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Ashworth, A., Hardman, H., Liu, W. -C, Maguire, S., Middleton, S., Dearden, L., Emmerson, C., Frayne, C., Goodman, A., Ichimura, H., and Megir, C.
- Abstract
One of the main aims of the Government's Connexions Strategy is to provide financial support for young people who might otherwise be unable to remain in fulltime education post-16; that is, after the end of compulsory schooling. EMA is a means-tested allowance available to 16 to 19 year olds. It aims to encourage participation, retention and achievement among young people, particularly those from low-income families. This evaluation focuses on the four models of EMA that were introduced into the original 15 pilot LEAs in September 1999. The pilots have subsequently been extended to a further 41 LEA areas. As well as evaluating the impact of EMA on participation, retention and achievement, the evaluation must also make recommendations on the level at which EMA should be set; the effectiveness of bonuses for retention and achievement; and to whom EMA should be paid (parent or young person). The evaluation will also address a range of subsidiary issues relating to the effect of EMA on young people's lives. The evaluation has four main elements, which combine both qualitative and quantitative research methods. This report focuses on the impact of EMA on those most directly affected, young people and their parents. It describes quantitative findings from the first wave of interviews with the first cohort of young people potentially eligible for EMA; those who completed compulsory education in summer 1999.
- Published
- 2001
14. Identification of a Titin-Derived HLA-A1–Presented Peptide as a Cross-Reactive Target for Engineered MAGE A3–Directed T Cells
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Cameron, Brian J., primary, Gerry, Andrew B., additional, Dukes, Joseph, additional, Harper, Jane V., additional, Kannan, Vivekanandan, additional, Bianchi, Frayne C., additional, Grand, Francis, additional, Brewer, Joanna E., additional, Gupta, Minnal, additional, Plesa, Gabriela, additional, Bossi, Giovanna, additional, Vuidepot, Annelise, additional, Powlesland, Alex S., additional, Legg, Alison, additional, Adams, Katherine J., additional, Bennett, Alan D., additional, Pumphrey, Nicholas J., additional, Williams, Daniel D., additional, Binder-Scholl, Gwendolyn, additional, Kulikovskaya, Irina, additional, Levine, Bruce L., additional, Riley, James L., additional, Varela-Rohena, Angel, additional, Stadtmauer, Edward A., additional, Rapoport, Aaron P., additional, Linette, Gerald P., additional, June, Carl H., additional, Hassan, Namir J., additional, Kalos, Michael, additional, and Jakobsen, Bent K., additional
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- 2013
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15. Alternate-Fueled Combustor-Sector Performance—Part A: Combustor Performance and Part B: Combustor Emissions
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Shouse, D. T., primary, Neuroth, C., additional, Hendricks, R. C., additional, Lynch, A., additional, Frayne, C. W., additional, Stutrud, J. S., additional, Corporan, E., additional, and Hankins, Capt. T., additional
- Published
- 2012
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16. Particulate Matter and Polycyclic Aromatic Hydrocarbon Determination using a Well-stirred Reactor (Postprint)
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AIR FORCE RESEARCH LAB TYNDALL AFB FL MATERIALS AND MANUFACTURING DIRECTORATE/AIRBASE TECHNOLOGIES DIV, Reich, R F, Frayne, C W, Zelina, J, Stouffer, S D, Katta, V R, Mayfield, H T, AIR FORCE RESEARCH LAB TYNDALL AFB FL MATERIALS AND MANUFACTURING DIRECTORATE/AIRBASE TECHNOLOGIES DIV, Reich, R F, Frayne, C W, Zelina, J, Stouffer, S D, Katta, V R, and Mayfield, H T
- Abstract
Combustion generated particulates from gas turbine combustors can cause adverse effects on engine maintenance costs, plume visibility and the environment. Research is being conducted to provide understanding of the mechanisms of soot formation and identify mitigation strategies. A cooled well-stirred reactor (WSR), which simulates the primary zone of a gas turbine combustor, is used in the current study. Experiments have been completed with premixed, fuel-rich (1.9 0 2.6) ethylene-air andethylene-ethanol-air mixtures. Multiple physical characteristics, including particle number density, particle size distribution, total carbon mass, and (polycyclic aromatic hydrocarbon) PAH content, were used to quantify the soot. A unique instrument, the Particulate Matter Characterization and Monitoring System (PMCMS), was used for the determination of the particle size distribution, and the chemical characterization of the soot and gaseous emissions. The results of the study showed that the benzene concentration in the gas phase increased monotonically with equivalence ratio while the pyrene was shown to correlate with the soot content. The results suggest that pyrene and other PAH species can be used to predict the soot formation for more complex combustion systems.For the conditions of the present study, the addition of ethanol to ethylene was shown to lower soot production compared to pure ethylene., Prepared in collaboration with the Air Force Research Laboratory, Propulsion Directorate, Wright-Patterson AFB, OH. Prepared in cooperation with the University of Dayton Research Institute, Dayton, OH, and Innovative Scientific Solutions, Inc., Dayton, OH. Presented at the 41st Aerospace Sciences Meeting and Exhibit held in Reno, NV on 6-9 Jan 2003. Published in AIAA Proceedings, 2003.
- Published
- 2003
17. Benchmarking Training and Development Practices: A Multi-Country Comparative Analysis
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Drost, E. A., primary, Frayne, C. A., additional, Lowe, K. B., additional, and Geringer, J. M., additional
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- 2002
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18. In Search of `Best Practices' in International Human Resource Management: Research Design and Methodology
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Geringer, J. M., primary, Frayne, C. A., additional, and Milliman, J. F., additional
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- 2002
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19. Combustion Air Jet Influence on Primary Zone Characteristics for Gas-Turbine Combustors
- Author
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Gogineni, S., primary, Shouse, D., additional, Frayne, C., additional, Stutrud, J., additional, and Sturgess, G., additional
- Published
- 2002
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20. Emissions and operability trades in the primary zones of gas turbine combustors
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Sturgess, G., primary, Gogineni, S., additional, Shouse, D., additional, Frayne, C., additional, and Stutrud, J., additional
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- 1996
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21. The role of transverse air jets in the formation of gas turbine emissions
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Shouse, D., primary, Frayne, C., additional, Stutrud, J., additional, Gogineni, S., additional, and Sturgess, G., additional
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- 1996
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22. TOWARD A THEORY OF COMPARATIVE MANAGEMENT RESEARCH: AN IDIOGRAPHIC CASE STUDY OF THE BEST INTERNATIONAL HUMAN RESOURCES MANAGEMENT PROJECT.
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Teagarden, M. B., primary, Von Glinow, M. A., additional, Bowen, D. A., additional, Frayne, C. A., additional, Nason, S., additional, Huo, Y. P., additional, Milliman, J., additional, Arias, M. E., additional, Butler, M. C., additional, Geringer, J. M., additional, Scullion, H., additional, Lowe, K. B., additional, and Drost, E. A., additional
- Published
- 1995
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23. Noninvasive brain stimulation may improve stroke-related dysphagia: a pilot study.
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Kumar S, Wagner CW, Frayne C, Zhu L, Selim M, Feng W, Schlaug G, Kumar, Sandeep, Wagner, Cynthia W, Frayne, Colleen, Zhu, Lin, Selim, Magdy, Feng, Wuwei, and Schlaug, Gottfried
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- 2011
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24. Neuropsychological assessment of an 8-year-old child following excision of a right temporal lobe oligodendroglioma.
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Frayne C, Leathem J, and O'Keefe V
- Abstract
A case of right temporal lobe oligodendroglioma in an 8-year-old female is reported. This case is unusual, because of the rarity of this type of tumour in children, because it was accompanied by seizure activity which is atypical, and because it highlights the difficulties in diagnosis. Prior to diagnosis, the background had included normal early development, followed by gradual development of partial complex seizures with poor response to medication in the absence of clear findings on EEG or CT. Considered to have been present prior to 1 year of age, the tumour was purported to be the aetiological base for seizure activity, which ceased after surgical excision. Post-surgical difficulties with academic progress and behaviour resulted in referral for neuropsychological evaluation, which revealed lowered overall cognitive functioning with deficits in processing speed, abstract verbal reasoning, concept formation, visual perception, visual reasoning, scanning, attention, memory, academic attainment and learning, and clerical motor speed. Behavioural functioning revealed impairment in social skills, irritability, impulsivity, and mood changes. The relative contributions of medication (adverse reaction and toxicity), long term seizure activity, early age of onset, and presence/excision of tumour are difficult to ascertain specifically. Findings appear consistent with those of right temporal lobe brain injury. [ABSTRACT FROM AUTHOR]
- Published
- 1999
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25. More and Better Results Through Concentration
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Hunsaker, P. and Frayne, C.
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Performance -- Measurement ,Industrial concentration -- Analysis ,Business ,Business, general ,Human resources and labor relations - Published
- 1983
26. 4.27 - Environmental Modification for Cooling, Heating and Potable Water Systems
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Frayne, C.
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27. Risk of Stroke-Associated Pneumonia and Oral Hygiene.
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Wagner C, Marchina S, Deveau JA, Frayne C, Sulmonte K, and Kumar S
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- Aged, Cohort Studies, Cross Infection complications, Female, Humans, Incidence, Logistic Models, Male, Multivariate Analysis, Odds Ratio, Pneumonia complications, Retrospective Studies, Stroke complications, Cross Infection epidemiology, Oral Hygiene methods, Pneumonia epidemiology, Stroke epidemiology
- Abstract
Background: Pneumonia is a major complication of stroke, but effective prevention strategies are lacking. Since aspiration of oropharyngeal secretions is the primary mechanism for development of stroke-associated pneumonia, strategies that decrease oral colonization with pathogenic bacteria may help curtail pneumonia risk. We therefore hypothesized that systematic oral care protocols can help decrease pneumonia risk in hospitalized stroke patients. In this study, we investigated the impact of a systematic oral hygiene care (OHC) program in reducing hospital-acquired pneumonia in patients with acute-subacute stroke., Methods: This study compared the proportion of pneumonia cases in hospitalized stroke patients before and after implementation of a systematic OHC intervention. All patients hospitalized with acute ischemic stroke or intracerebral hemorrhage admitted to a large, urban academic medical center in Boston, Mass., USA from May 31, 2008, to June 1, 2010 (epoch prior to implementation of OHC), and from January 1, 2012, to December 31, 2013 (epoch after full implementation of OHC), who were 18 years of age and hospitalized for ≥ 2 days were eligible for inclusion. The cohort in the first epoch constituted the control group whereas the cohort in the second epoch formed the intervention group. Multivariate logistic regression was used to control for confounders. The main outcome measure was hospital-acquired pneumonia, defined via International Classification of Diseases, Ninth Revision, Clinical Modification codes., Results: The cohort comprised 1,656 admissions (707 formed historical controls; 949 were in the intervention group). The unadjusted incidence of hospital-acquired pneumonia was lower in the group assigned to OHC compared to controls (14 vs. 10.33%; p = 0.022) with an unadjusted OR of 0.68 (95% CI 0.48-0.95; p = 0.022). After adjustment for influential confounders, the OR of hospital-acquired pneumonia in the intervention group remained significantly lower at 0.71 (95% CI 0.51-0.98; p = 0.041)., Conclusion: In this large hospital-based cohort of patients admitted with acute stroke, systematic OHC use was associated with decreased odds of hospital-acquired pneumonia., (© 2015 S. Karger AG, Basel.)
- Published
- 2016
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28. Predictors of percutaneous endoscopic gastrostomy tube placement in patients with severe dysphagia from an acute-subacute hemispheric infarction.
- Author
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Kumar S, Langmore S, Goddeau RP Jr, Alhazzani A, Selim M, Caplan LR, Zhu L, Safdar A, Wagner C, Frayne C, Searls DE, and Schlaug G
- Subjects
- Aged, Boston, Deglutition Disorders diagnosis, Deglutition Disorders etiology, Deglutition Disorders physiopathology, Disability Evaluation, Female, Humans, Logistic Models, Magnetic Resonance Imaging, Male, Multivariate Analysis, Odds Ratio, Retrospective Studies, Risk Assessment, Risk Factors, Severity of Illness Index, Stroke diagnosis, Stroke physiopathology, Treatment Outcome, Cerebrum blood supply, Deglutition Disorders surgery, Endoscopy, Gastrointestinal instrumentation, Enteral Nutrition instrumentation, Gastrostomy instrumentation, Stroke complications
- Abstract
This study investigated the influence of age, National Institutes of Health Stroke Scale (NIHSS) score, time from stroke onset, infarct location and volume in predicting placement of a percutaneous endoscopic gastrostomy (PEG) tube in patients with severe dysphagia from an acute-subacute hemispheric infarction. We performed a retrospective analysis of a hospital-based patient cohort to analyze the effect of the aforementioned variables on the decision of whether or not to place a PEG tube. Consecutive patients were identified using International Classification of Diseases, Ninth Revision (ICD-9) codes for acute ischemic stroke, Current Procedural Terminology (CPT)-4 codes for a formal swallowing evaluation by a speech pathologist, and procedure codes for PEG placement over a 5-year period from existing medical records at our institution. Only patients with severe dysphagia were enrolled. A total of 77 patients met inclusion criteria; 20 of them underwent PEG placement. The relationship between age (dichotomized; < and ≥75 years), time from stroke onset (days), NIHSS score, acute infarct lesion volume (dichotomized; < and ≥100 cc), and infarct location (ie, insula, anterior insula, periventricular white matter, inferior frontal gyrus, motor cortex, or bilateral hemispheres) with PEG tube placement were analyzed using logistic regression analysis. In univariate analysis, NIHSS score (P = .005), lesion volume (P = .022), and presence of bihemispheric infarction (P = .005) were found to be the main predictors of interest. After multivariate adjustment, only NIHSS score (odds ratio [OR], 1.15; 90% confidence interval [CI], 1.02-1.29; P = .04) and presence of bihemispheric infarcts (OR, 4.67; 90% CI, 1.58-13.75; P = .018) remained significant. Our data indicates that baseline NIHSS score and the presence of bihemispheric infarcts predict PEG placement during hospitalization from an acute-subacute hemispheric infarction in patients with severe dysphagia. These results require further validation in future studies., (Copyright © 2012 National Stroke Association. Published by Elsevier Inc. All rights reserved.)
- Published
- 2012
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29. Win-win treatment. Interview by Lynne Wallis.
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Bowden-Jones H and Frayne C
- Subjects
- Humans, London, Nurse Clinicians organization & administration, Nurse Clinicians psychology, Nurse's Role, Nursing Assessment, Psychiatric Nursing organization & administration, Referral and Consultation statistics & numerical data, State Medicine organization & administration, Ambulatory Care Facilities organization & administration, Gambling psychology, Mental Health Services organization & administration, Psychiatry organization & administration
- Abstract
Addiction to gambling tends to be a hidden problem but now the UK's first NHS-funded treatment unit is attempting to tackle it.
- Published
- 2009
30. Self-management training for improving job performance: a field experiment involving salespeople.
- Author
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Frayne CA and Geringer JM
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- Analysis of Variance, Efficiency, Female, Humans, Male, Motivation, North America, Psychological Theory, Inservice Training methods, Insurance, Life, Self Efficacy
- Abstract
In a control-group field experiment using a reversal design, 30 insurance salespeople were randomly assigned to an experimental group that received self-management training. A multivariate analysis of variance and subsequent repeated-measures analyses of variance revealed that, compared with a control condition (n = 30), training in self-management skills significantly improved job performance as assessed through both objective and subjective measures. Performance improvement continued with time, and increases were sustained across a 12-month period posttraining. Subsequent training of the control group produced similar increases in self-efficacy, outcome expectancies, and job performance. Potential mediating effects of self-efficacy and outcome expectancies on the self-management-performance relationship were explored and partially supported.
- Published
- 2000
- Full Text
- View/download PDF
31. Strategies for successful interpersonal negotiating.
- Author
-
Frayne CA and Hunsaker PL
- Subjects
- Humans, Administrative Personnel psychology, Interpersonal Relations, Personnel Management
- Abstract
Human resources managers frequently find themselves in positions in which they must negotiate--with applicants, employees, subordinates, superiors, or peers. It is important, therefore, that they know the techniques that will enable them to wind up in an win/win situation. Authors Colette A. Frayne, doctoral candidate at the University of Washington, and Phillip L. Hunsaker, professor of management and director of management programs at the University of San Diego, spell out techniques to be used before, during, and after negotiations to reach the best possible solution for both sides.
- Published
- 1984
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