542 results on '"Frattola, L."'
Search Results
2. Bovine spongiform encephalopathy and Creutzfeldt-Jakob disease: facts and uncertainties underlying the causal link between animal and human diseases
- Author
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Beghi, E., Gandolfo, C., Ferrarese, C., Rizzuto, N., Poli, G., Tonini, M. C., Vita, G., Leone, M., Logroscino, G., Granieri, E., Salemi, G., Savettieri, G., Frattola, L., Ru, G., Mancardi, G. L., and Messina, C.
- Published
- 2004
- Full Text
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3. Assessing clinically relevant cognitive decline: preliminary data on a new method
- Author
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Isella, V., Atzeni, L., Iurlaro, S., Villa, M. L., Russo, A., Forapani, E., Frattola, L., and Appollonio, I. M.
- Published
- 2003
- Full Text
- View/download PDF
4. Physical anhedonia in Parkinson's disease
- Author
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Isella, V, Iurlaro, S, Piolti, R, Ferrarese, C, Frattola, L, and Appollonio, I
- Subjects
Anhedonia -- Diagnosis -- Evaluation -- Complications and side effects ,Parkinson's disease -- Complications and side effects -- Diagnosis ,Statistics ,Neuropsychological tests ,Health ,Psychology and mental health ,Diagnosis ,Evaluation ,Complications and side effects - Abstract
Besides motor and cognitive symptoms, affective and behavioural disturbances are often observed during the course of Parkinson's disease (PD). (1) Attention of clinicians and researchers has classically focused on depression, [...]
- Published
- 2003
5. Reduced platelet glutamate uptake in Parkinson's disease
- Author
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Ferrarese, C., Zoia, C., Pecora, N., Piolti, R., Frigo, M., Bianchi, G., Sala, G., Begni, B., Riva, R., and Frattola, L.
- Published
- 1999
- Full Text
- View/download PDF
6. Modifications of diazepam binding inhibitor and peripheral benzodiazepine receptors in the lymphocytes of epileptic patients
- Author
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Ferrarese C., Perego M., Marzorati C., Bianchi G., Frigo M., Pecora N., Riva R., Moretti G., and Frattola L.
- Published
- 1996
- Full Text
- View/download PDF
7. Fourth meeting of the European Neurological Society 25–29 June 1994 Barcelona, Spain: Abstracts of Symposia and free communications
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Harms, L., Bock, A., JÄnisch, W., Valdueza, J., Weber, J., Link, I., De Keyser, J., Goossens, A., Wilczak, N., Vedeler, C., Bjorge, L., Uvestad, E., Conti, G., Williams, K., Ginsberg, L., Rafique, S., Rapoport, S. I., Gershfeld, N. L., De La Meilleure, G., Crevits, L., Faiss, J. H., Heye, N., Blanke, J., Sackmann, A., Kastrup, O., Doornbos, R., van der Worp, H. B., Kappelle, L. J., Bar, P. R., Davie, C. A., Barker, G. J., Brenton, D., Miller, D. H., Thompson, A. J., Block, F., Schwarz, M., Delodovici, L., Baruzzi, F., Bonaldi, G., Dario, A., Marra, A., Mercuri, A., Dworzak, F., Cavallari, P., Confalonieri, P., Zuffi, M., Antozzi, C., Cornelio, F., Baldissera, F., Chassande, B., Ameri, A., Eymard, B., Poisson, M., Vérier, A., Brunet, P., Congia, S., Murgia, P. L., Cannas, A., Borghero, G., Uselli, S., Mellino, G., Ferrai, R., Lampis, R., Massa, R., Muzzetto, B., Giannini, F., Rossi, S., Cioni, R., d'Aniello, C., Guarneri, A., Battistini, N., Ceriani, F., Del Santo, A., Poloni, M., Campo, J. F., Iglesias, F., Guitera, M. V., Farinas, C., Pascual, J., Leno, C., Berciano, J., Thorpe, I. W., Kendall, B. E., McDonald, W. I., Moulignier, A., Dromer, F., Baudrimont, M., Dupont, B., Gozlan, J., El Amrani, M., Petit, J. C., Roullet, E., Sterzi, R., Causaran, R., Protti, A., Riva, M., Erminio, F., Arena, O., Villa, F., Maccagnano, E., Miletta, M., Spinelli, F., Ben-Hur, T., Weidenfeldl, J., Rao, N. S., Chari, C. C., Laforet, P., Matheron, S., Adams, D., Chemouilli, Ph., Desi, M., Said, G., Davous, P., Lionnet, F., Pulik, M., Genet, P., Rozenberg, F., Cartier, L. M., Castillo, J. L., Cea, J. G., Villagra, R., de Saint Martin, L., Mahieux, F., Manifacier, M. J., Mattos, K., Queiros, C., Publio, L., Vinhas, V., PeÇanha-Martins, A. C., Melo, A., Liska, U., Zifko, U., Budka, H., Drlicek, M., Grisold, W., Kaufmann, R., Kaiser, R., Czygan, M., Gomes, I., Jones, N., Cunha, S., EmbiruÇu, E. Katiane, Vieira, V., Araujo, I., Alexandra, M., Ferreira, A., Goes, J., Chemouilli, P., Israel-Biet, Masson, H., Lacroix, C., Gasnault, J., Hildebrandt-Müller, B., Oschmann, P., Krack, P., Willems, W. R., Dorndorf, W., Freitas, V., Bittencourt, A., Fernandes, D., Nascimento, M. H., Severo, M., Moraes, D., Muller, M., Hasert, K., Merkelbach, S., Schimrigk, K., van Oosten, B. W., Lai, M., Polman, C. H., Bertelsmann, F. W., Hodgkinson, S., Cabre, P. H., Volpe, L., Smadja, D., Vernant, J. P., Villaroya, H., Violleau, K., Younes-Chennoufi, A. Ben, Baumann, N., Villanueva-Hemandez, P., Ballabriga, J., Basart, E., Arbizu, T. X., Perez-Serra, J., Vinuels, F., Giron, J. M., Castilla, J. M., Redondo, L., Izquierdo, G., Lauer, K., Henneberg, A., Bittmann, N., Link, D., Wollinsky, K. H., Mobner, R., Fassbender, K., Kuhnen, J., Schwartz, A., Hennerici, M., Miller, A., Lider, O., Abramsky, O., Weiner, H. L., Offner, H., Vanderbark, A. A., Paoino, E., Fainardi, E., Addonizio, M. C., Ruppi, P., Tola, M. R., Granieri, E., Carreras, M., Sazdovitch, V., Joutel, A., Verdier-taillefer, M. H., Heinzlef, O., Radder, C., Tournier-Lasserve, E., Brenner, R. E., Munro, P. M. G., Williams, S. C. R., Bell, J. D., Hawkins, C. P., Filippi, M., Campi, A., Dousset, V., Canal, N., Comi, G., Zhu, J., Weber, F., Retska, R., List, J., Zhang, L., Brock, M., Taphoorn, M. J. B., Heimans, J. J., van der Veen, E. A., Karim, A. B. M. F., Sarazin, M., Argentino, N., Delattre, J. Y., Derkinderen, P., Buchwald, B., Schroter, G., Serve, G., Franke, C. H., Conrad, B., Kitchen, N. D., Thomas, D. G. T., Forman, A. D., Ang, Kie- Kian, Price, R., Stephens, C., Salmaggi, A., Nermni, R., Silvani, A., Forno, M. G., Luksch, R., Boiardi, A., Grzelec, H., Fryze, C., Nowacki, P., Zdziarska, B., Sanson, M., Merel, P., Richard, S., Rouleau, G., Thomas, G., Olsen, N. K., Pfeiffer, P., Egund, N., Bentzen, S. M., Johannesen, L., Mondrup, K., Rose, C., Zyluk, B., Wondrusch, E., Berger, O., Fast, N., Jellinger, K., Lindner, K., Urman, A., Thibault, J. L., Duyckaerts, Ch., Strik, H., Muller, B., Richter, E., Krauseneck, P., Steinbrecher, A., Schabet, M., Hess, C., Bamberg, M., Dichgans, J., Counsell, C. E., McLeod, M., Grant, R., Creel, G. B., Claus, D., Sieber, E., Engelhardt, A., Rechlin, T., Thierauf, P., Neubauer, U., Peresson, M., Di Giovacchino, G., Romani, G. L., Di Silverio, F., Danek, A., Kuffner, M., Hoermann, R., Schopohl, J., Laska, M., Heye, B., Zangaladze, A. T., Valls-SoIè, J., Cammarota, A., Alvarez, R., Tolosa, E., Hallett, M., Ulbricht, D., Ganslandt, O., Kober, H., Vieth, J., Grummich, P., Pongratz, H., Brigel, C., Fahlbusch, R., Serra, F. P., Palma, V., Nolfe, G., Buscaino, G. A., Rothstein, T. L., Gibson J. M., Morrison P. M., Collins A. D., Eiselt, M., Wagnur, H., Zwiener, U., Schindler, T., Efendi, H., Ertekin, C., Erfas, M., Larsson, L. E., Sirin, H., AraÇ, N., Toygar, A., Demir, Y., Seddigh, S., Vogt, T. H., Hundemer, H., Visbeck, A., Pastena, L., Faralli, F., Mainardi, G., Gagliardi, R., Linden, D., Berlit, P., Lopez, O. L., Becker, J. T., Jungreis, C., Brenner, R., Rezek, D., Dekesky, S. T., Estol, C., Boller, F., Fernandez, J. M., Mederer, S., Batlle, J., Turon, A., Codina, A., Hitzenberger, P., Vila, N., Valls-SolÇ, J., Chamorro, A., Pouget, J., Schmied, A., Morin, D., Azulay, J. Ph., Vedel, J. P., Montalt, J., Escudero, J., Barona, R., Campos, A., Varli, K., Ertem, E., Uludag, B., Yagiz, A., Privorkin, Z., Steinvil, Y., Kott, E., Combarros, O., Sanchez-Pernaute, R., Orizaola, P., Mokrusch, Th., Kutluaye, E., Selcuki, D., Ertikin, C., Zettl, U., Gold, R., Harvey, G. K., Hartung, H. P., Toyka, K. V., Wokke, J. H. J., Oey, P. L., Ippel, P. F., Jansen, G. H., Franssen, H., Toyooka, K., Fujimura, H., Ueno, S., Yoshikawa, H., Yorifuji, S., Yanagihara, T., Talamon, C., Tzourio, C., Kiefer, R., Jung, S., Toyka, K., Ruolt, I., Tranchant, C., Mohr, M., Warter, J. M., Younger, D. S., Rosoklija, G., Hays, A. P., Kurita, R., Hasegawa, O., Matsumto, M., Komiyama, A., Nara, Y., Oueslati, S., Belal, S., Turki, I., Ben Hamida, C., Hentati, F., Ben Hamida, M., Kwiecinski, H., Krolicki, L., Domzal-Stryga, A., Dellemijn, P. L. I., van Deventer, P., van Moll, B., Drogendijk, T., Vecht, Ch. J., Nemni S., Amadio, Fazio, R., Galardin, G., Delodovici, M. L., Peghi, E., Monticelli, M. L., Sessa, A., Viguera, M. L., Palomar, M., Gamez, J., Cervera, C., Navarro, C., Serena, J., Duran, I., Fernandez, A. L., Comabella, M., Nos, C., Rio, J., Montalban, J., Navarro, X., Verdu, E., Darbra, S., Buti, M., Mrabet, A., Fredj, M., Gouider, R., Tounsi, H., Khalfallah, N., Haddad, A., Dbaiss, T., Ghnassia, R., Rouillet, E., Chedru, F., Porsche, H., Strenge, H., Li, S. W., Young, Y. P., Garcia, A. A., Baron, P., Scarpini, E., Bianchi, R., Conti, A., Livraghi, S., Rees, J. H., Gregson, N. A., Hughes, R. A. C., Sedano, M. J., Calleja, J., Canga, E., Bahou, Y., Biary, N., Al Deeb, S. M., Guern, E. L. E., Gugenheim, M., Tardieu, S., Aisonobe, T. M., Agid, Y., Bouche, P., Brice, A., Rautenstrauss, B., Nelis, E., Grehl, H., Van Broeckhoven, C., Pfeiffer, R. A., Liehr, T., Ganzmann, E., Gehring, C., Neundörfer, B., Geremia, L., Doronzo, R., Sacilotto, G., Sergi, P., Pastorino, G. C., Scarlato, G., Planté-Bordeneuve, V., Mantel, A., Baas, F., Moser, H., Antonini, A., Psylla, M., Günther, I., Vontobell, P., Beer, H. F., Leenders, K. L., Chaudhuri, K. Ray, Parker, J., Pye, I. F., Millac, P. A. H., Abbott, R. J., Sutter, M., Albani, C., de Rijk, M. C., Breteler, M. M. B., Graveland, G. A., van der Mechè, F. G. A., Hofman, A., Keipes, M., Hilger, Ch., Diederich, N., Metz, H., Hentges, F., Pollak, P., Benabid, A. L., Limousin, P., Hoffmann, D., Benazzouz, A., Perret, J., Laihinen, A., Rinne, J. O., Ruottinen, H., Nagren, K., Lehikoinen, P., Oikonen, V., Ruotsalainen, U., Rinne, U. K., Cocozza, S., Pizzuti, A., Cavalcanti, F., Monticelli, A., Pianese, L., Redolfi, E., Paiau, F., Di Donato, S., Pandolfo, M., Palau, F., Monros, E., De Michele, G., Smeyers, P., Lopez-ArLandis, J., Uilchez, J., Filla, A., Genis, D., Matilla, T., Volpini, V., Blanchs, M. I., Davalos, A., Molins, A., Rosell, J., Estivill, X., De Jonghe, P., Smeyers, G., Krols, L., Mercelis, R., Hazan, J., Weissenbach, J., Martin, J. J., Warner, T. A. T., Williams, L., Orb, A. S., Harding, A. E., Giunti, P., Sweeney, M. G., Spadaro, M., Jodice, C., Novelletto, A., Malaspina, P., Frontali, M., Salmon, E., Gregoire, Del Fiore, Comar, Franck, G., Scheltens, P. H., Siegfried, K., Dartigues, E., De Deyn, P., Horn, R., Nelson, I., Hanna, M. G., Morgan-Hughes, J. A., Collinge, J., Palmer, M. S., Campbell, T., Mahal, S., Sidle, K., Humphreys, C., Tavitian, B., Pappata, S., Jobert, A., Crouzel, A. M., DiGiamberardino, L., Steimetz, G., Barbanti, P., Fabbrini, G., Salvatore, M., Buzzi, M. G., Di Piero, V., Petraroli, R., Sbriccoli, A., Pocchiari, M., Macchi, G., Lenzi, G. L., Spiegel, R., Maguire, P., Schmid, W., Ott, A., Bots, M. L., Grobbe, D. E., Hofman, A., Howard, R. S., Russell, S., Losseff, N., Hirsch, N. P., Couderc, R., Bailleul, S., Nargeot, M. C., Touchon, J., Picot, M. C., Rizzo, M., Watson, G., McGehee, D., Dingus, T., Kappos, L., Radü, E. W., Haas, J., Hartard, C. H., Spuler, S., Yousry, T., Voltz, R., Scheller, A., Holler, E., Hohlfeld, R., Scolding, N. J., Sussman, J., Kolar, O. J., Farlow, M. R., Rice, P. H., Zipp, F., Sotgiu, S., Weiss, E. H., Wekerle, H., Chalmers, R., Robertson, N., Compston, D. A. S., Martino, G., Clementi, E., Brambilla, E., Moiola, L., Martinelli, V., Colombo, B., Poggi, A., Rovaris, M., Grimaldi, L. M. E., Roth, M. P., Descoins, P., Ballivet, S., Ruidavets, J. B., Waubant, E., Nogueira, L., Cambon-Thomsen, A., Clanet, M., Leppert, D., Hauser, S., Lugaresi, A., Tartaro, A., D'aurelio, P., Befalo, L. L. O., Thomas, A., Malatesta, G., Gambi, D., Benedikz, J. E. G., Magnusson, H., Poser, C. M., Guomundsson, G., Bates, T. E., Davies, S. E. C., Clark, J. B., Landon, D. N., ùther, J. R., Rautenberg, W., Overgaard, K., Sereghy, T., Pedersen, H., Boysen, G., Diez-Tejedor, E., Carceller, F., Gutierrez, M., Lopez-Pajares, R., Roda, J. M., Chandra, B., Ricart, W., Gonzalez-Huix, F., Molina, A., Rundek, T., Demarin, V., De Reuck, J., Boon, P., Decoq, D., Strijckmans, K., Goethals, P., Lemahieu, I., Nibbio, A., Chabriat, H., Vahedi, K., Nagy, T., Verin, M., Mas, J. L., Julien, J., Ducrocq, X., Iba-Zizen, M. T., Cabanis, E. A., Bousser, M. G., Rolland, Y., Landgraf, F., Bompais, B., Lemaitre, M. H., Edan, G., Vorstrup, S., Knudsen, L., Olsen, K. Skovgaard, Videbaek, C., Schroeder, T., van Gijn, J., Jansen, H. M. L., Pruim, J., Paans, A. M. J., Willemsen, A. T. M., Hew, J. M., vd Vliet, A. M., Haaxma, R., Vaalburg, W., Minderhoud, J. M., Korf, J., Soudain, S. E., Ho, T. W., Mishu, B., Li, C. Y., Nachainkin, I., Gao, C. Y., Cornblath, D. R., Griffin, J. W., Asbury, A. K., Blaser, M. J., McKhann, G. M., Ho, T., Macko, C., Xue, P., Stadlan, E. M., Ramos-Alvarez, M., Valenciano, L., Visser, L. H., van der Meché, F. G. A., van Darn, P. A., Meulstee, J., Schmitz, P. I. M., Jacobs, B., Oomes, P. G., Kleyweg, R. P., Jacobs, B. C., Endtz, H. P., van Doorn, P. A., van der Mech, F. G. A., Van den Berg, L. H., Mollee, I., Logtenberg, T., Thomas, P. K., Plant, G., Baxter, P. J., Luis, R. Santiago, Matsumoto, M., Notermans, N. C., Wokke, J. H. J., Lokhorst, H. M., van der Graaf, Y., Jennekens, F. G. I., Azulay, J. P., Bille-Turg, F., Valentin, P., Farnarier, G. G., Pellissier, J. F., Serratrice, G., Quasthoff, S., Schneider, U., Grafe, P., Hilkens, P. H. E., Moll, J. W. B., van der Burg, M. E. L., Planting, A. S. T., van Putten, W. L. J., van den Bent, M. J., Birklein, F., Spitzer, A., Lang, E., Neundorfer, B., Diehl, R. R., Lücke, D., Smith, G. D. P., Mathias, C. J., Serra, J., Campera, M., Ochoa, J. L., Ray Chaudhuri, K., Pavitt, D., Alam, M., Handwerker, H. O., Bleasdale-Barr, K., Smith, G., Murray, N. M. F., Hawkins, P., Pepys, M., Gellera, C., DiDonato, S., Taroni, F., Uncini, A., Di Muzio, A., Servidei, S., Silvestri, G., Lodi, R., Iotti, S., Barbiroli, B., Morrissey, S. P., Borruat, F. X., Francis, D., Mosely, I., Hansen, H. C., Helmke, K., Kunze, K., Sadzot, B., Maquet, P., Lemaire, Plenevaux, Damhaut, Sommer, C., Myers, R. R., Berta, E., Mantegazza, R., Argov, Z., Shapira, Y., Wirguin, I., Beuuer, J., Franke, C., Roberts, M., Willison, H., Vincent, A., Newsom-Davis, J., Morrison, K. E., Damels, R., Francis, M., Campbell, L., Davies, K. E., Kohler, W., Bucka, C., Hertel, G., Kanovsky, P., Auer, D., Ackermann, H., Klose, U., Naegele, Th., Bien, S., Voigt, K., Fink, G. R., Stephan, K. M., Wise, R. J. S., Mullatti, N., Hewer, L., Frackowiak, R. S. J., Weiller, C. S., Rijnites, M., Jueptner, M., Bauermann, T., Krams, M., Diener, H. C., van Walderveen, M. A. A., Barkhof, F., Hommes, O. R., Valk, J., Willmer, J. P., Guzman, D. A., Passingham, R. E., Silbersweig, D., Ceballos-Baumann, A., Frith, C. D., Frackowiak, R., Lucas, C. H., Goullard, L., Marchau, M. J., Godefroy, O., Rondepierre, P. H., Chamas, E., Mounier-Vehier, F., Leys, D., Renato, J., Verdugo, M. S. C., Campero, M., Jose, L., Ochoa, D. S. C., Vivancos, F., Tejedor, E. Diez, Martinez, N., Roda, J., Frank, A., Barreiro, P., Satoh, Y., Nagata, K., Maeda, T., Hirata, Y., YalÇinerner, B., Ozkara, C., Ozer, F., Ozer, S., Hanoglu, L., Zunker, P., Pozo, J. L., Oberwittler, C., Schick, A., Buschmann, H. -Ch., Ringelstein, E. Bernd, Lara, M., Anzola, G. P., Magoni, M., Volta, G. Dalla, Tarasov, A., Feigin, V., Beaudry, M. G., Carrier, S., Chicoutimi, Henriques, I. L., Bogoussslavsky, J., van Melle, G., Mathieu, J., Perusse, L., Allard, P., Prevost, C., Cantin, L., Bouchard, J. M., De Braekeleer, M., Agbo, C., Neau, J. P., Tantot, A. M., Dary-Auriol, M., Ingrand, P., Gil, R., Baltadjiev, D., Zekin, D., Sabey, K., Gennaula, C. P., Pope, B. A., Caparros-Lefebvre, D., Girard-Buttaz, I., Pruvo, J. P., Petit, H., Hipola, D., Martin, M., Giménez-Roldan, S., Ivanez, V., Japaridze, G., Carrasco, J. L., Picomell, I., Herranz, J. L., Macias, J. A., Nieto, M., Noya, M., Oller, L., Kiteva-Trencevska, G., Delgado, M. R., Liu, H., Luengo, A., Parra, J., Colas, J., Fernandez, M. J., Manzanares, R., Kornhuber, M. E., Malashkhia, V., Orkodashili, G., Martinez, M., Bonaventura, I., Porta, G., Martinez, I., Fernandez, A., Aguilar, M., Masnou, P., Drouet, A., Dreyfus, M., Cartron, J., Morel-Kopp, M. C., Tchernia, G., Kaplan, C., Lammers, M. W., Hekster, Y. A., Keyser, A., Meinardi, H., Renier, W. O., Boon, P. A. J. M., Have, M. D., Kint, B., Cruz, P., Cadilha, A., Almeida, R., Goncalves, M., Pimenta, M., Ramos, L. M. P., Polder, T. W., Broere, C. A., Polman, L., Rother, I., Rother, M., Schlaug, G., Arnold, S., Holthausen, H., Wunderlich, G., Ebner, A., Luders, H., Witte, O. W., Seitz, R. J., Serra, L. L., Gallicchio, B., Rotondi, F., Wieshmann, U., Meierkord, H., Sabev, K., Di Carlo, V., Gueguen, B., Derouesné, Ch., Ancri, D., Bourdel, M. C., Guillou, S., Aliaga, R., Chornet, M. A., Rodrigo, A., Pascual, A. Pascual -Leone, Catala, M. D., Pascual-Leone, A., Benbadis, S. R., Dinner, D. S., Chelune, G. J., Lüders, H. O., Piedmonte, M. R., Blanco, T., Lopez, M. P., Romero, B., Deltoro, A., Pascual, A., Pascual, Leone, Bolgert, F., Josse, M. O., Tassan, P., Touze, E., Laplane, D., Godenberg, F., Brizioli, E., Del Gobbo, M., Pelliccioni, G., Scarpino, O., Durak, H., Damlacik, G., Tunca, Z., Fidaner, H., Yurekli, Y., Yemez, B., Kaygisiz, A., Anllo, E. A., Esperet, E., Giovagnoli, A. R., Casazza, M., Spreafico, R., Avanzini, G., Mascheroni, S., Vecchio, I., Tornali, C., Antonuzzo, A., Grasso, A. A., Bella, R., Pennisi, G., Raffaele, R., Broeckx, J., Schildermans, F., Hospers, W., Deberdt, W., Carney, J. M., Aksenova, M., Chen, M. S., Juncadella, M., Busquets, N., De la Fuente, I., Rodriguez, A., Rubio, F., Soler, R., Khati, C., Pillon, B., Deweer, B., Malapani, C., Malichard, N., Dubois, B., Rancurel, G., Lopez, D. L., Jungreia, G., DeKosky, S. T., Boiler, F., Weiller, C., Rijntjes, M., Mueller, S. P., Maguire, E. A., Burke, E. T., Staunton, H., Phillips, J., Rousseaux, M., Pena, J., Bertran, I., Santacruz, P., Lopez, R., Catafau, A., Lomena, F., Blesa, R., Rampello, L., Nicoletti, A., Cabaret, M., Lesoin, F., Steinling, M., Tournev, I., Maier-Hauff, K., Schroeder, M., Wolf, A., Cochin, J. P., Noel, I., Augustin, P., Auzou, P., Hannequin, D., Maria, V., Lopez-Bresnahan, Danielle, D. M., Antin-Ozerkis B. A., Bartels, E., Rodiek, S. O., Flugel, K. A., Campos, D. M., Salas-Puig, J., Del Rio, J. Sanhez, Vidal, J. A., Lahoz, C. H., Eraksoy, M., Barlas, O., Barlas, M., Bayindir, C., Ozcan, H., Birbamer, G., Gerstenbrand, F., Felber, S., Luz, G., Aichner, F., Seidel, G., Kaps, M., Hutzelmann, A., Gerriets, T., Kruggel, F., Martin, P. J., Gaunt, M. E., Abbot, R. J., Naylor, A. R., Meary, E., Dilouya, A., Meder, J. F., De Recondo, J., Lebtahi, R., Neff, K. W., Meairs, S., Viola, S., Matta, E., Aquilone, L., Rise, I. R., Authier, F. J., Kondo, H., Ghnassia, R. T., Degos, J. D., Gherardi, R. K., Bardoni A., Ciafaloni E., Comi G. P., Bresolin N., Robotti M., Moggio M., Rigoletto C., Roses A., Scarlato G., Castelli, E., Turconi, A., Bresolin, N., Perani, D., Felisari, G., Chariot, P., de Pinieux, G., Astier, A., Jacotot, B., Gherardi, R., Fischer-Gagnepain, V., Louboutin, J. P., Crespo, F., Florea-Strat, A., Fromont, G., Sabourin, J. -C., Gonano, E. -F., Moroni, I., Prelle, A., Iannaccone, S., Quattrini, A., deRino, F., Sessa, M., Golzi, V., Smirne, S., Nemni, R., Turpin, J. C., Lucotte, G., Jacobs, S. C. J. M., Willems, P. W. A., Bootsma, A. L., Lasa, A., Calaf, M., Baiget, M., Gallano, B., Fichter-Gagnepain, V., Mazzucchelli, F., D'Angelo, M. G., Velicogna, M., Bet, L., Comi, G. P., Bordoni, A., Gonano, E. F., Bazzi, P., Rapuzzi, S., Moggio, M., Fagiolari, G., Ciscato, P., Messina, A., Battistel, A., Ryniewicz, B., Sangla, I., Desnuelle, C., Paquis, V., Cozzone, P. J., Bendahan, D., Sturenburg, H. J., Kohncke, G., Castellli, E., Linssen, W., Stegeman, D., Binkhorst, R., Notermans, S., Jaspert, A., Fahsold, R., de Munain, A. Lopez, Cobo, A., Martorell, L., Poza, J. J., Navarrete Palau, D., Emparanza, J. I., Sanchez-Roy, R., Vilchez, J. J., Hernandez, M., Tena, J. Garcia, Perla, C., Koutroumanidis, M., Papathanasopoulos, P., Papadimitriou, A., Papapetropoulos, T. H., Divari, R., Hadjigeorgiou, G. M., Anastasopoulos, I., Sansone, V., Rotondo, G., Meola, G., Rigoletto, C., Messina, S., Szwabowska-Orzeszko, E., Jozwiak, S., Michalowicz, R., Szaplyko, W., Petrella, M. A., Della Marca, G., Masullo, G., Mennuni, G. F., Kompf, D., Wascher, E., Verleger, R., Kaido, M., Soga, F., Toyooka, H., Bayon, C., Rubio, J., Carlomagno, S., Parlato, V., Santoro, A., Lavarone, A., Bonavita, V., Pentore, R., Venneri, A., Pasquier, F., Lebert, F., Grymonprez, L., Lefebvre, C., Van der Linden, M., Derouesné, C., Renault, B., Lacomblez, L., Homeyer, P., Ouss, L., Neuman, E., Malbezin, M., Barrandon, S., Guez, D., Stevens, M., van Swieten, J. C., Franke, C. L., Sanchez, A., Castellvirel, S., Mila, M., Jimenez, D., Pallesta, F., Ruiz, P. J. Garcia, Barrio, A., Barroso, T., Benitez, J., de Yebenes, J. Garcia, Manubens, J. M., Martinez-Lage, J. M., Larumbe, R., Muruzabal, J., Lacruz, F., Quesada, Pedro, Gallego, J., Ferini-Strambi, L., Marcone, A., Garancini, P., Tedesi, B., Jacob, B., Rozewicz, L., Langdon, D., Davie, C., Ron, M., Thompson, A., Koepp, M. J., Hansen, M. L., Guldin, B., Pressler, R. M., Ried, S., Scholz, C., Monaco, F., Gianelli, M., Schiavalla, M. P., Naldi, P., Cantello, R., Torta, R., Verze, L., Mutani, R., Knott, H., Ferbert, A., Schulze-Bonhage, A., Aust, W., Di Mascio, R., Marchioli, R., Vitullo, F., Di Pasquale, A., Sciulli, L., Kramer, V., Tognoni, G., Santacruz, P., Lopez, R., Marti, M. J., Charques, I., Catafau, A., Lomeila, F., Peila, J., Bertran, I., Blesa, R., Krendel, D. A., Costiga, D. A., Koeppen, S., Korn, W. M., Brugge, S., Schmitz, D., Scheulen, M. E., King, R. H. M., Robertson, A. M., Thomas, P. K., Kerkhofs, A., Vermersch, P., Dereeper, O., Daems Monpeun, C., Parent, M., Deplanque, D., Petit, H., Campero, M., Serra, J., Ochoa, J. L., Martinez-Matos, J. A., Montero, J., Olivé, M., Rene, R., Vidaller, A., Gugenheim, M., Gouider, R., Le Guern, E., Brice, A., Agid, Y., Bouche, P., Grisold, W., Ziflo, U., Drlicek, M., Budka, H., Jellinger, K., Zielinski, C. H., Ginsberg, L., King, R. H. M., Workman, J., Platts, A. D., Thomas, P. K., Gherardi, R. K., Florea-Strat, A., Poron, F., Sabourin, J. -C., Fazio, R., Nemni, R., Franceschi, M., Lorenzetti, I., Rinaldi, L., Canal, N., Weilbach, F. X., Sennlaub, A., Jung, S., Gold, R., Toyka, K. V., Hartung, H. P., Giegerich, G., Ellie, E., Vital, A., Steck, A. J., Vital, C., Julien, J., Doneda, P., Pizzul, S., Scarpini, E., Chiodi, P., Ramacci, M. T., Livraghi, S., Maimone, D., Annunziata, P., Salvadori, C., Guazzi, G. C., Arne-Bes, M. C., Delisle, M. B., Fabre, N., Hurtevent, J. F., Bes, A., Baudoin-Martin, D., Laborde, E., Viallet, F., Creisson, C., Crespi, V., Bogliun, G., Marzorati, L., Zincone, A., D'Angelo, L., Liberani, A., Merlini, M., Rivolta, R., Creange, A., Sabourin, J. -C., Theodorou, I., Gherardi, R. K., Conti, A. M., Malosio, M. L., Baron, P. L., Scarlato, G., Chorao, R., Rosas, M. J., Leite, I., Callea, L., Donati, E., Bargnani, C., Bud, M., Verdu, E., Navarro, X., Braun, S., Einius, S., Poindron, P., Warier, J. M., Bradley, J., Bekkelund, S. I., Torbergsen, T., Mellgren, S. I., Carlomagno, S., Parlato, V., Santoro, A., Lavarone, A., Boller, F., Bonavita, V., Engelhardt, A., Lörler, H., Robeck, S., Kluglein, C., Comi, G., Avoledo, V., Locatelli, T., Leocani, L., Galardi, G., Magnani, G., Medaglini, S., Chkhikvishvili, T. S., Zangaladze, A., Bratoeva, M., Kovachev, P., Chavdarov, D., Artemis, N., Karacostas, D., Milonas, I., Arpa, J., Lopez-Pajares, R., Cruz-Matinez, A., Sarria, J., Palomo, F., Alonso, M., Rodriguez-Al-barino, A., Lacasa, T., Nos, J., Barreiro, P., Martinez, A. Cruz, Villoslada, C., Alons, M., Taghavy, A., Hamer, H., Kratzer, A., Dethy, S., Pauwels, T., Monclus, M., Luxen, A., Goldman, S., Ziegler, M., Crambes, O., Ragueneau, I., Arnaud, F., Zappia, M., Montesanti, R., Colao, R., Palmieri, A., Branca, D., Nicoletti, G., Rizzo, M., Parlato, G., Quattrone, A., Vanacore, N., Zuchegna, P., Bonifati, V., Meco, G., Scholz, J., Friedrich, H. -J., Rohl, A., Ulm, G., Vieregge, P., Savettieri, G., Rocca, W. A., Meneghini, F., Grigoletto, F., Morgante, L., Reggio, A., Salemi, G., Di Pierri, R., OzckmekÇi, S., Ertan, S., Yeni, N., Apaydin, H., Erkol, G., Kiziltan, G., Denktas, F., Ranoux, D., de Recondo, J., Ostergaard, L., Werdelin, L., Odin, P., Lindvall, O., Dupont, E., Christensen, P. B., Boisen, E., Jensen, N. B., Schmiegelow, M., Ingwersen, S. H., Matias-Guiu, J., Canet, T., Falip, R., Martin, R., Galiano, L., Voloshin, M. Y., Burchinskaya, L. F., Cabrera-Valdivia, F., Jimenez-Jimenez, F. J., Molina, J. A., Fernandez-Calle, P., Vazquez, A., Canizares-Liebana, F., Larumbe-Lobalde, S., Ayuso-Peralta, L., Rabasa, M., Codoceo, R., Arrieta, F. J., Aguilar, M. V., Jorge-Santamaria, A., Martinez-Para, M. C., Alarcon, J., Mateo, D., Gimenez-Roldan, S., Gencheva, E., Tzonev, T. z., Georgiev, G., Petkova, P., Gasparini, M., Vanacore, N., Meco, N. G., de la Sierra, G., Aguado, F., Revilla, M., Varela, L., Rico, H., Feve, A., N'Guyen, J. P., Bathien, N., Fenelon, G., Veroust, J., Cesaro, P., Egersbach, G., Hattig, H., Schelosky, L., Wissel, J., Poewe, W., Durif, F., Albuisson, E., Debilly, B., Tournilhac, M., Magnani, C., Mocellini, C., Soffietti, R., Schiffer, D., Cardozo, A., Cruz-Sanchez, F. F., Falip, L., Potagas, G., Ziegler, M., Rondot, P., Bonifati, V., Fabrizio, E., Meco, G., Bostantjopoulou, S., Katsarou, Z., Kyriazis, G., Baas, H., Demisch, L., Esser, A., Zoeller, F., Burklin, F., Harder, S., Fischer, P. A., Arcusa, M. J., Hermandez, S., Claramonte, F. J., Pascual, A. Pascual- Leone, Alonso, M. D., Catata, M. D., Alessandri, A., Giustini, P., Dufour, A., Ciusani, E., Nespolo, A., Roelcke U., Radu E. W., von Ammon K., Maguire R. P., Leenders K. L., Radionova, M., Chavdarov, D., Bratoeva, M., Tzekov, Ch., Pietrangeli, A., Bove, L., Pace, A., Falqui, L., Jandolo, B., Potemkowski, A., Muller B., Reinhard I., Krone A., Warmuth M., Brocker E. M., Krauseneck P., Meyding-Lamadé, U., Krieger, D., Sartor, K., Hacke, W., Maugard-Louboutin, C., Fayet, G., Sagan, C., Martin, S., Ménégalli, D., Lajat, Y., Resche, F., Koriech, O. M., Al Moutaery, K., Yaqub, B., Jochens, R., Wolters, A., Venz, S., Cordes, M., Hecht, B. K., Chatel, M., Gaudray, P., Turc-Carel, C., Gioanni, J., Ayraud, N., Hecht, F., Rumbach, L., Racadot, E., Bataillard, M., Billot, M., Pariset, J., Wijdenes, J., Montalban, Rio J., Tintoré, M., Galan, I., Acarin, N., Rapaport, S., Huberman, M., Shechtcr, D., Karabudak, R., Kilinc, M., Boyacigil, S., Cila, A., Polo, J. M., Setien, S., Sanchez, R., Figols, J., Zubimendi, A., Nadareishvili, Z. G., Massot, R., Marés, R., Gallecho, F., Richart, C., Hernandez, M. A., Garcia, M. R., Lorenzo, J. N., Leon, C., Muros, M., Togores, J., Kutluk, K., Damlacik, G. A., Tekinsoy, B., Obuz, O., Baklan, B., Idiman, E., Genc, K., Zielasek, J., Schmidt, B., Liew, F. Y., Gulay, Z., Yulug, N., Wong, K. S., Wong, T. W., Yu, T. S., Kay, R., Poupon, R., Giral, P., Roberti, C., Zanette, E. M., Chiarotti, F., Brusa, L., Cerbo, R., Prusinski, A., Pondal, M., Canton, R., Dominigo, Erodriguez J., Pereira Monteino J. M., Pereira Monteino X., Pardo, J., Carroacedo, A., Barros, F., Lema, M., Castillo, J., Melchor, A., Montiel, I., Guiu, J. Matias, Kloss, T. M., Keidel, M., Jacob, M., Idiman, F., Idman, E., Ozturk, V., Metin, E., Yilmaz, M., Gerard, J. M., Bouton, R., Decamps, D., Herbaut, A. G., Delecluse, F., Cavenaile, M., Divano, L., Chazot, G., Boureau, F., Emile, J., Bertin, L., d'Allens, H., Ferro, J. M., Costa, I., Carletto, F., Catarci, T., Padovani, A., Iandolo, B., Bartoli, M., Bonamini, M., Pulcinelli, F., Pignatelli, P., Russo, M., Gazzaniga, P. P., Barros, J., Pinheiro, J., Correia, A. P., Monteiro, J. M. Pereira, Alvarez-Cermeno, J. C., Avello, G., Sastre, J. L., Vecino, A., Cesar, J. M., Leone, M., Stankov, B., D'Amico, D., Maltempo, C., Moschian, F., Fraschini, F., Bussone, G., Molto, J. M., Fernandez, E., Fernandez, A. Morento, Barreiro, A., Siclia, J., Castejon, P., Mihout, B., Malberin, M., Salzman, V., Bogousslavsky, J., Meneghetti, G., Baracchini, C., Bozzato, G., Marini, B., Mendel, T., Czlonkowska, A., Pasierski, T., Szwed, H., Marta-Moreno, J., Lopez-Delval, J., Mostacero, E., Morales, F., Mahagne, M. H., Rogopoulos, A., Bertrand, F., Bedoucha, P., Lanteri-Minet, M., Riva, D., Zorzi, C., Milani, N., Vajsar, J., Ronen, G., Macgregor, D., Becker, L., Susseve, J., Seidl, Z., Faber, J., Obenberger, J., Springer, R., Bax, R. T., Eckardt, T., Czettritz, G. V., Emmrich, P., Vlaski-Jekic, S., Petrova, V., Cherninkova, S., Gudeva, T., Tzekov, C., Devoti, M., Franceschetti, S., Mientus, S., Vienna, P., Vashtang, Y., Tazir, M., Assami, S., Oulbani, D., Kaci Ahmed, M. Ait, Andersen, G., Vestergaard, K., Riis, J. O., Chavdarov, D., Corbo, M., Previtali, S., Allen, R. R., McKay, W. C., Rowbotham, M. C., Castellvi-Pel, S., Banchs, I., Kruyer, H., Corral, J., Saugeir-Veber, P., Munnich, A., Bonneau, D., Rozet, J. M., Le Merrer, M., Boespflug-Tanguy, O., Gokyigit, A., Oktem, O., Demir, G., Caliskan, A., Gardiner, R. M., Shorvon, Simon, Wieser, Heinz -Gregor, Hossmann, K. A., Steinberg, A., van Crevel, H., Ducros, A., Labauge, P., Pinsard, N., Ponsot, G., Gouttiere, F., Gastaut, J. L., Delrieu, O., BesanÇon, V., Klopstock, T., May, A., Seibel, P., Papagiannuli, E., Reichmann, H., Gurses, C., Aykut, C., Aktan, S., De Vuono, G., Fiacco, F., Gazzaniga Pozzill, P. P., Assuerus, V., Jacomet, C., Picard, O., Rozenbaum, W., Nueckel, M., Osschmann, P., Horning, C. R., Caldarelli-Stefano, R., Omodeo-Zorini, E., Rivolta, G. E., Maserati, R., Cagni, A., Ferrante, P., Lamadé, W., Heb, Th., Gosztonyl, G., Daral, G., Fresquet, C., Storch-Hagenlocher, B., Wildemann, B., Jager, G., Fuhry, L., Van Paesschen, W., Grunewald, R. A., Duncan, J. S., Connelly, A., Jackson, G. D., Sisodiya, S., Raymond, A. A., Shorvon, S. D., Fish, D. R., Stevens, J. M., Savic, I., Pauli, S., Thorell, J. O., Browne, R. H., Kornhuber, J., Retz, W., Riederer, P., Boon, F., Calliauw, L., Hoksergen, I., Thiery, E., Caemert, J., Decoo, D., Desomer, A., Chevalier, Y., Grinspan, A., Hirsch, E., Moszkowski, J., Marescaux, C., Yaqub, B. A., Valdueza, J. M., Puchner, M. J. A., Dammann, O., Vortmeyer, A., Herrmann, H. -D., Peterson, W., Prevett, M. C., Cunningham, V., Brooks, D. J., Pomes, A., Sunol, C., Durwen, H. F., Confavreux, Ch., Grimaud, J., Saddier, P., Moreau, T., Cortinovis-Tourniaire, P., Aimard, G., Adeleine, P., Paty, D. W., Wiles, C. M., Midgard, R., Riise, T., Kvale, G., Nyland, H., Stodal, H., Haase, A., Lassmann, H., Deeb, S. M. Al., Bruyn, G. W., Semana, G., Teisserenc, H., Alizadeh, M., Loiseau, P., Birebent, B., Yaouanq, J., Genetet, B., Sabouraud, O., Charron, D. J., Shaw, C. E., Stelmasiak, C., Solski, J., Nowicki, J., Jakubowska, B., Ryba, M., Grieb, P., Garcia-Merino, A., Usuku, K., Yunis, E., Alper, C., Hauser, S. L., Betuel, H., Gebuhrer, L., Salier, J. P., Kellar-Wood, H., Govan, G. G., Bromberg, J. E. C., Rinkel, G. J. E., Algra, A., Moulin, T., Stojkovic, T., Chavrot, D., Klotzsch, C., Kaiser-Rub, K., Nahser, H. C., Klijn, C. J. M., Tulleken, C. A. F., Rappelle, L. J., Daffertshofer, M., Kother, J., Hornig, C. R., Rust, D. S., Busse, O., Laun, A., Corabianu, O., Berbinschi, A., Chastang, C., Cophignon, J., Haguenau, M., Ketelslegers, J. M., Jander, S., Kramer, M., Schröter, M., Witte, O. W., Stoll, G., Möbner, R., Barak, V., Sarova-Ponchas, I., Holon, Le Coz, P., Woimant, F., George, B., Merland, J. J., Chleide, E., Casademont, J., Barrientos, A., Cardellach, F., Cervantes, F., Grau, J. M., Montoya, J., Rozman, C., Urbano-Marquez, A., Nunes, V., Lane, R. J. M., Archard, L. C., Schapira, A. H. V., Cooper, J. M., Barnes, P. R. J., Kemp, G. 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8. Evaluation by somatosensory evoked potentials of the neurotoxicity of cisplatin alone or in combination with glutathione
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Bogliun G., Marzorati L., Cavaletti G., and Frattola L.
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- 1992
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9. Extracorporeal photochemotherapy in relapsing/remitting multiple sclerosis
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Perseghin, P, Dassi, M, Cavarretta, R, Tagliabue, E, Zoia, C, Grimaldi, M, Oggioni, N, Stanzani, L, Tavecchia, L, Frattola, L, Frigo, M, and Cavaletti, G
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10. Acute noise stress in rats increases the levels of diazepam binding inhibitor (DBI) in hippocampus and adrenal gland
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Ferrarese, C., Mennini, T., Pecora, N., Gobbi, M., Appollonio, I., Bernasconi, P., Frigo, M., Regondi, C., Pierpaoli, C., Frattola, L., and Garattini, S.
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- 1991
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11. Cognitve estimation: comparison of two tests in nondemented parkinsonian patients
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Appollonio, I. M., Russo, A., Isella, V., Forapani, E., Villa, M. L., Piolti, R., and Frattola, L.
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- 2003
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12. Nerve Growth Factor and Transforming Growth Factor-β Serum Levels in Acute Stroke Patients: Possible Involvement of Neurotrophins in Cerebrovascular Disease
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Stanzani, L., Zoia, C., Sala, G., Appollonio, I., Frattola, L., De Simoni, M. G., and Ferrarese, C.
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13. Alpha-dihydroergocryptine in the treatment of de novo parkinsonian patients: results of a multicentre, randomized, double-blind, placebo-controlled study
- Author
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Bergamasco, B., Frattola, L., Muratorio, A., Piccoli, F., Mailland, F., and Parnetti, L.
- Published
- 2000
14. Elevated Glutamate in the Cerebrospinal Fluid of Patients With HIV Dementia
- Author
-
Ferrarese, Carlo, Riva, Riccardo, Dolara, Alberto, De Micheli, Anna, and Frattola, L.
- Published
- 1997
15. Posatirelin in the treatment of vascular dementia: a double-blind multicentre study vs placebo
- Author
-
Parnetti, L., Ambrosoli, L., Agliati, G., Caratozzolo, P., Fossati, L., Frattola, L., Martucci, N., Murri, L., Nappi, G., Puca, F. M., Poli, A., Girardello, R., and Senin, U.
- Published
- 1996
16. Screening cognitive decline in dementia: preliminary data on the Italian version of the IQCODE
- Author
-
Isella, V., Villa, M.L., Frattola, L., and Appollonio, I.
- Published
- 2002
- Full Text
- View/download PDF
17. Decreased platelet glutamate uptake and genetic risk factors in patients with Parkinson's disease
- Author
-
Ferrarese, C., Tremolizzo, L., Rigoldi, M., Sala, G., Begni, B., Brighina, L., Ricci, G., Albizzati, M. G., Piolti, R., Crosti, F., Dalprà, L., and Frattola, L.
- Published
- 2001
- Full Text
- View/download PDF
18. Physiologic study of the subthalamic volume
- Author
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Zincone, A., Landi, A., Piolti, R., Appollonio, I., Mariani, C. B., Pezzoli, G., Gaini, S. M., and Frattola, L.
- Published
- 2001
- Full Text
- View/download PDF
19. Benzodiazepine-induced chemotaxis is impaired in monocytes from patients with generalized anxiety disorder
- Author
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Sacerdote, P., Panerai, A.E., Frattola, L., and Ferrarese, C.
- Published
- 1999
- Full Text
- View/download PDF
20. Effect of Aspirin and Dipyridamole on Platelet Function and on Neurologic Evaluation of Patients Affected by Stroke or Transient Ischemic Attacks
- Author
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Polli, E. E., Cortellaro, M., Frattola, L., Randazzo, A., Candelise, L., Pogliani, E., Politi, A., Bassi, S., Scotti, G., Santambrogio, S., Agnoli, Alessandro, editor, and Fazio, Cornelio, editor
- Published
- 1977
- Full Text
- View/download PDF
21. Subacute Phase of Stroke Treated with Ganglioside GM1
- Author
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Bassi, S., Albizzati, M. G., Sbacchi, M., Frattola, L., Massarotti, M., Tettamanti, Guido, editor, Ledeen, Robert W., editor, Sandhoff, Konrad, editor, Nagai, Yoshitaka, editor, and Toffano, Gino, editor
- Published
- 1986
- Full Text
- View/download PDF
22. Extracorporeal photochemotherapy: a safety and tolerability pilot study with preliminary efficacy results in refractory relapsing-remitting multiple sclerosis
- Author
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Cavaletti, G, Perseghin, P, Dassi, M, Cavarretta, R, Frigo, M, Caputo, D, Stanzani, L, Tagliabue, E, Zoia, C, Grimaldi, M, Isella, V, Rota, S, Ferrarese, C, Frattola, L, CAVALETTI, GUIDO ANGELO, ZOIA, CHIARA PAOLA, ISELLA, VALERIA, ROTA, STEFANIA, FERRARESE, CARLO, Frattola, L., Cavaletti, G, Perseghin, P, Dassi, M, Cavarretta, R, Frigo, M, Caputo, D, Stanzani, L, Tagliabue, E, Zoia, C, Grimaldi, M, Isella, V, Rota, S, Ferrarese, C, Frattola, L, CAVALETTI, GUIDO ANGELO, ZOIA, CHIARA PAOLA, ISELLA, VALERIA, ROTA, STEFANIA, FERRARESE, CARLO, and Frattola, L.
- Abstract
Extracorporeal photochemotherapy (ECP) is an immunomodulating procedure consisting of autologous reinfusion of peripheral blood mononuclear cells (PBMC) after direct exposure to 8-methoxy-psoralen and UV-A. It has been described as a successful treatment for different T-cell-mediated diseases and preliminary results suggest that ECP might be effective in the treatment of relapsing-remitting multiple sclerosis, but does not significantly alter the course of the progressive form of MS. In this study, we report the safety data and some preliminary efficacy evidence obtained using ECP in the treatment of five patients with refractory relapsing-remitting (RR) MS: in most cases ECP induced a reduction in the relapse rate and an EDSS stabilisation, with an apparent general MRI stabilisation. In conclusion, our results confirm ECP safety and tolerability and suggest that this treatment might be useful as a therapeutic alternative in the subgroup of RRMS patients not responsive to or not eligible for traditional immunomodulating or immunosuppressive treatments
- Published
- 2006
23. Increased glutamate in CSF and plasma of patients with HIV dementia
- Author
-
Ferrarese, C, Aliprandi, A, Tremolizzo, L, Stanzani, L, DE MICHELI, A, Dolara, A, Frattola, L, FERRARESE, CARLO, ALIPRANDI, ANGELO, TREMOLIZZO, LUCIO, STANZANI, LORENZO, DE MICHELI, ANNA, DOLARA, ALBERTO, Frattola, L., Ferrarese, C, Aliprandi, A, Tremolizzo, L, Stanzani, L, DE MICHELI, A, Dolara, A, Frattola, L, FERRARESE, CARLO, ALIPRANDI, ANGELO, TREMOLIZZO, LUCIO, STANZANI, LORENZO, DE MICHELI, ANNA, DOLARA, ALBERTO, and Frattola, L.
- Abstract
Experimental evidence suggests that excitotoxicity might play a major role in HIV-induced neurodegeneration. However, few studies have investigated the role of endogenous glutamate in patients with HIV dementia.
- Published
- 2001
24. Decreased platelet glutamate uptake and genetic risk factors in patients with Parkinson's disease
- Author
-
Ferrarese, C, Tremolizzo, L, Rigoldi, M, Sala, G, Begni, B, Brighina, L, Ricci, G, Albizzati, M, Piolti, R, Crosti, F, Dalprà, L, Frattola, L, Albizzati, MG, Frattola, L., Ferrarese, C, Tremolizzo, L, Rigoldi, M, Sala, G, Begni, B, Brighina, L, Ricci, G, Albizzati, M, Piolti, R, Crosti, F, Dalprà, L, Frattola, L, Albizzati, MG, and Frattola, L.
- Abstract
Genetic risk factors seem to play a role in sporadic Parkinson's disease (PD), maybe triggering oxidative stress and excitotoxicity within substantia nigra. However, genetic factors act at systemic level: reduced activity of mitochondrial enzymes and decreased glutamate uptake have been shown in platelets from PD patients. In this study we investigated glutamate uptake in platelets from 38 sporadic PD patients, 13 patients with parkinsonian syndromes and 28 controls and assessed polymorphisms of alpha -synuclein and ApoE genes. A 48% reduction of glutamate uptake (p<0.0001) was observed in PD patients which, with respect to control groups, correlated with the disease severity (r = -0.44, p < 0.05). Genetic studies of this population did not show differences between PD and controls, nor correlations with platelet glutamate uptake
- Published
- 2001
25. Mitsuyama variant in the association ALS-dementia
- Author
-
Appollonio, I, Cavarretta, R, Melzi, P, Apale, P, Curtò, N, Frattola, L, APPOLLONIO, ILDEBRANDO, Frattola, L., Appollonio, I, Cavarretta, R, Melzi, P, Apale, P, Curtò, N, Frattola, L, APPOLLONIO, ILDEBRANDO, and Frattola, L.
- Abstract
Mitsuyama variant in the association ALS-dementia. We report a case characterized by the association of an early-onset, rapidly progressive and severe dementia with the subsequent appearance of a motoneuron disease (bulbar ALS). The neuropsychological evaluation showed a global cognitive impairment, with a more profound impairment of executive, linguistic and mnestic functions, as in fronto-temporal dementia. SPECT and PET investigations demonstrated a bilateral reduction of blood perfusion and glucose metabolism in the frontal and temporal lobes. Brain MRI showed a diffuse cortical atrophy, more pronounced at the level of the frontal lobes. The characteristics of the present case are in agreement with the clinical variant first described by Mytsuyama in eastern patients. However, our case differs for the extremely rapid onset and progression of cognitive decline and this could suggest that the complexity of the association between fronto-temporal dementia and ALS is even more heterogeneous than reported up-to-date.
- Published
- 2000
26. Thalamic dementia: Report of a case due to unilateral paramedian infarct of the left thalamus
- Author
-
Isella, V, Santoro, P, Frattola, L, Ferrarese, C, Appollonio, I, ISELLA, VALERIA, Frattola L, FERRARESE, CARLO, APPOLLONIO, ILDEBRANDO, Isella, V, Santoro, P, Frattola, L, Ferrarese, C, Appollonio, I, ISELLA, VALERIA, Frattola L, FERRARESE, CARLO, and APPOLLONIO, ILDEBRANDO
- Abstract
Thalamic dementia is an infrequent condition characterized by memory deficits and frontal-like behavioral disturbances which are usually due to bilateral (anterior or paramedian) thalamic lesions of various origin. Cases due to a unilateral infarct have only been reported rarely and are the subject of discussion. Here we describe the case of a 67-year-old man, retired, showing the typical clinical and neuropsychological features of thalamic dementia as a consequence mainly of unilateral infarct of the anterior and paramedian part of the left thalamus. At the onset, the patient presented with transient diplopia and vertigo, drowsiness, severe ideomotor slowing, general disorientation, reduced verbal fluency, and both retro- and anterograde amnesia. The neurological examination at admission also showed mild dysmetria at the right upper limb and unsteady gait. During the following weeks, there was a progressive recovery of retrograde memory and of spatial, temporal and personal orientation; ideomotor slowing and hypersomnia partially abated. Anterograde memory deficits, behavioral disturbances, and changes in personality became prominent. The patient appeared considerably apathetic, and indifferent to the environment and presented with a prevalent anxiety-depression mood state, associated with occasional subeuphoric and jocular attitudes. Formal neuropsychological testing was performed 1 year after the onset of symptoms. The patient appeared distractable and showed moderate reduction of psychomotor speed; he was partially aware of his memory problems, even if unconcerned. Spontaneous speech was poor, but grammatically intact. At the MMSE the patient lost points for time orientation and on recall of three items (corrected total score = 26.5/30). The memory tasks revealed a marked reduction in verbal memory ability; performance at attention and fluency tasks were low-average. There was no evidence of aphasia, apraxia, agnosia, and visuospatial deficits. The Neuropsychiat
- Published
- 2000
27. Reduced platelet glutamate uptake in Parkinson's disease
- Author
-
Ferrarese, C, Zoia, C, Pecora, N, Piolti, R, Frigo, M, Bianchi, G, Sala, G, Begni, B, Riva, R, Frattola, L, FERRARESE, CARLO, ZOIA, CHIARA PAOLA, PECORA, NICOLETTA, FRIGO, MARTA, BIANCHI, GIANLUIGI, SALA, GESSICA, Frattola, L., Ferrarese, C, Zoia, C, Pecora, N, Piolti, R, Frigo, M, Bianchi, G, Sala, G, Begni, B, Riva, R, Frattola, L, FERRARESE, CARLO, ZOIA, CHIARA PAOLA, PECORA, NICOLETTA, FRIGO, MARTA, BIANCHI, GIANLUIGI, SALA, GESSICA, and Frattola, L.
- Abstract
Defects in mitochondrial enzymes have been found not only in substantia nigra, but also in platelets from Parkinson's Disease (PD) patients, suggesting a systemic impairment of energy metabolism. Since platelets present an energy-dependent glutamate uptake similar to that described in central nervous system, glutamate uptake was determined in platelets from 34PD patients and 21 age-related normal controls, as Na+-dependent [3H]glutamate influx; glutamate level was also analyzed by reverse-phase HPLC. A 50% reduction of glutamate uptake (p < 0.001) was observed in idiopathic PD patients, respect to controls and secondary parkinsonian syndromes. The decrease correlated with the severity of PD, measured by the UPDRS (r = -0.54; P < 0.05). Glutamate level was increased in platelets of PD patients, but was not correlated to the uptake decrease. Both phoenomena may be explained by the modifications of mitochondrial enzymes described in platelets, which could be used as a peripheral model of glutamatergic function in PD
- Published
- 1999
28. Parkinson's disease - Associated cognitive impairment: neuropsychological and neuroradiological data. MRI indexes of temporal and frontal atrophy [Compromissione cognitiva nella malattia di Parkinson: Sinergismo discriminativo neuropsicologico e neuroradiologico. Analisi multivariata di indici RM lineari di atrofia frontale e temporale]
- Author
-
Iurlaro, S, Isella, V, Grimaldi, M, Piolti, R, Melzi, P, Appollonio, I, Frattola, L, Frattola, L., ISELLA, VALERIA, APPOLLONIO, ILDEBRANDO, Iurlaro, S, Isella, V, Grimaldi, M, Piolti, R, Melzi, P, Appollonio, I, Frattola, L, Frattola, L., ISELLA, VALERIA, and APPOLLONIO, ILDEBRANDO
- Abstract
Parkinson's Disease (PD)-associated cognitive impairment is frequent, yet often difficult to diagnose early and precisely. Given the promising results of linear and volumetric MRI studies in dementia of Alzheimer's type and in other types of dementia, we tested the discriminative accuracy of linear measures of frontal and temporal atrophy and their value in supporting the classical clinical and psychometric diagnostic criteria for dementia in Parkinson's disease. Demographic, clinical, neuropsychological and neuroradiological data were collected from 38 subjects (14 controls, 14 patients with idiopathic PD without dementia, 10 patients with idiopathic PD and dementia). Some neuroradiological indexes of temporal and frontal atrophy, which we have investigated in our study, have a significant discriminative power for dementia that increase sinergically those of the neuropsychological indexes.
- Published
- 1999
29. Emotional and affective disturbance in patients with epilepsy and diabetes and in normal individuals
- Author
-
Beghi, E, Spagnoli, P, Airoldi, L, Fiordelli, E, Appollonio, I, Bogliun, G, Paleari, F, Gamba, P, Frattola, L, Frattola, L., APPOLLONIO, ILDEBRANDO, Beghi, E, Spagnoli, P, Airoldi, L, Fiordelli, E, Appollonio, I, Bogliun, G, Paleari, F, Gamba, P, Frattola, L, Frattola, L., and APPOLLONIO, ILDEBRANDO
- Published
- 1999
30. Choline acetyltransferase activity in human muscular diseases
- Author
-
Frattola, L., Pezzoli, G., Canal, N., and Trabucchi, M.
- Published
- 1976
- Full Text
- View/download PDF
31. Lipid changes in neurogenic muscular atrophies
- Author
-
Frattola, L., Canal, N., Andreoli, V. M., Maffei, F., and Tonon, G. C.
- Published
- 1974
- Full Text
- View/download PDF
32. The metabolism of cyclic-3′-5′-adenosine monophosphate (cAMP) in diseased muscle
- Author
-
Canal, N., Frattola, L., and Smirne, S.
- Published
- 1975
- Full Text
- View/download PDF
33. Cyclandelate versus Flunarizine: A Double-Blind Study in a Selected Group of Patients with Dementia
- Author
-
Albizzati, M. G., Bassi, S., Calloni, E., Sbacchi, M., Piolti, R., and Frattola, L.
- Published
- 1987
- Full Text
- View/download PDF
34. Using a single question to screen for depression in the nursing home
- Author
-
Gori, C, Appollonio, I, Riva, G, Spiga, D, Ferrari, A, Trabucchi, M, Frattola, L, Riva, GP, Frattola, L., APPOLLONIO, ILDEBRANDO, Gori, C, Appollonio, I, Riva, G, Spiga, D, Ferrari, A, Trabucchi, M, Frattola, L, Riva, GP, Frattola, L., and APPOLLONIO, ILDEBRANDO
- Abstract
The geriatric depression scale (GDS) is the most common instrument for the evaluation of depression in the elderly, but some of its items do not easily fit with the nursing-home setting. Different short-version of the GDS have already been proposed, but they have shortcomings, too. This work was aimed at verifying the possibility of using a single question as a screening instrument for depression in the nursing-home population. The full-length Italian version of the GDS (GDS-30) was administered in a single nursing-home to all institutionalized women (61 patients) with a mini mental state examination (MMSE) score greater than 15. The results of the 30-item and of the 15-item versions were subsequently computed. Following a previous report, we identified the 16th item of the GDS-30 as the critical one for single-question screening. On the basis of the GDS-30, 24 women (39.3 %) had a score higher than 10. Using the GDS-30 as the criterion, the single-question had a sensitivity and a specificity of 95.8 and 83.8 %, respectively. By contrast, the GDS-15 had a lower sensitivity (79.2 %), although its specificity (97.3 %) was better. Given that sensitivity has higher value than specificity for the screening of highly impairing diseases, our results support a preference given to the single-question compared to the GDS-15. Moreover, the single question had almost the same accuracy as the GDS-30, without being time consuming and overcoming the difficulties of administration of the latter in the nursing home population.
- Published
- 1998
35. Dati normativi per le versioni italiane delle scale di apatia e di anedonia
- Author
-
Isella, V, Appollonio, I, Meregalli, L, Melzi, P, Iurlaro, S, Frattola, L, ISELLA, VALERIA, APPOLLONIO, ILDEBRANDO, Frattola, L., Isella, V, Appollonio, I, Meregalli, L, Melzi, P, Iurlaro, S, Frattola, L, ISELLA, VALERIA, APPOLLONIO, ILDEBRANDO, and Frattola, L.
- Abstract
Apathy and anhedonia are symptoms common in various neuropsychiatric disorders; specific tools for their assessment have been developed in the USA and are already available in French: Marin's 18-item apathy scale, Chapman's 61-item physical anhedonia scale and the pleasure/displeasure scale. Through the present study, normative values have been obtained for the Italian versions of these three scales which can now be used for clinical and research purposes.
- Published
- 1998
36. Skeletal muscle glycogenosis type II: Biochemical and electron microscopic investigations of one case
- Author
-
Canal, N., Frattola, L., and Pellegrini, G.
- Published
- 1972
- Full Text
- View/download PDF
37. Which diagnostic procedures in the elderly? The case of late-onset Huntington's disease
- Author
-
Appollonio, I, Frisoni, G, Curtò, N, Trabucchi, M, Frattola, L, APPOLLONIO, ILDEBRANDO, Frattola, L., Appollonio, I, Frisoni, G, Curtò, N, Trabucchi, M, Frattola, L, APPOLLONIO, ILDEBRANDO, and Frattola, L.
- Abstract
The typical adult-onset form of Huntington's disease (HD) is a clinical condition in which the latest advances of genetic research can be usefully applied during the course of the diagnostic process; not so clear are the guidelines for the much less frequent late-onset variant. We have recently seen three patients in their late sixties who had been misdiagnosed for up to 10 years due to the apparently isolated, mild, and slowly progressive nature of their hyperkinetic movements or cognitive disorders. Only after the results of DNA sequencing on a blood sample became available could the appropriate diagnosis of late-onset HD be reached. By contrast, neuroimaging studies lacked sufficient sensitivity and specificity. Appropriate neurogeriatric assessment in these cases should follow specific guidelines and should always include selected high-technology procedures.
- Published
- 1997
38. Isolated dementia in two patients with posterior intraventricular meningiomas
- Author
-
Isella, V, Appollonio, I, Piolti, R, Gaini, S, Frattola, L, ISELLA, VALERIA, APPOLLONIO, ILDEBRANDO, Gaini, SM, Frattola, L., Isella, V, Appollonio, I, Piolti, R, Gaini, S, Frattola, L, ISELLA, VALERIA, APPOLLONIO, ILDEBRANDO, Gaini, SM, and Frattola, L.
- Abstract
Although patients with brain lesions of neurosurgical interest may sometimes present with a cognitive profile very similar to a primary dementia, they usually have a history and/or a neurologic examination which alert the clinician. The occurrence of mass lesions with purely isolated cognitive deterioration has been mainly reported for locations at the level of the frontal lobes. A potentially positive prognosis is advocated in these cases, in terms of even complete reversibility of the mental impairment when surgical removal is feasible and successful. We report two rare cases of posterior intraventricular meningiomas presenting with isolated cognitive and behavioural changes consistent with a frontal type dementia; the outcome was favourable in one patient, whereas the second one suffered from massive intracerebral bleeding during the neurosurgical removal and required prolonged hospitalization and subsequent intensive neurorehabilitative efforts. By comparing our cases with previously published decision-rules regarding neuroimaging in dementia, we suggest that criteria should be enlarged, especially those regarding the age of the subject and the time elapsed from the first signs of the cognitive deterioration.
- Published
- 1997
39. Anhedonia in Parkinson's Disease
- Author
-
Isella, V, Appollonio, I, Melzi, P, Piolti, R, Frattola, L, ISELLA, VALERIA, APPOLLONIO, ILDEBRANDO, Frattola, L., Isella, V, Appollonio, I, Melzi, P, Piolti, R, Frattola, L, ISELLA, VALERIA, APPOLLONIO, ILDEBRANDO, and Frattola, L.
- Abstract
Anhedonia (that is the inability to take pleasure in any physical or social experience) has never been assessed in Parkinson's Disease (PD); its evaluation might integrate the usual neuropsychological profile of the disease and allow anhedonia itself to be better defined (either component of a mood disorder or deriving from orbito-frontal dysfunction). We examined a series of 17 nondemented parkinsonian patients and IS age-, sexand education-matched controls for the presence of affective and cognitive disturbances using a psychometric battery that included frontal tests and the Chapman's Scales for physical and social anhedonia (1). Patients with PD had significantly higher anhedonia scores and they also obtained abnormal depression and frontal-executive tasks scores; correlation analysis was then performed and showed no significant association between either the Geriatric Depression Scale or the Executive Interview on one side and Chapman's Scales on the other. The relationship between anhedonia, mood level and cognitive (mainly disexecutive) aspects will be discussed. Further neuropsychological data are now being processed concerning a group of demented parkinsonian patients. (1) Chapman L et al: Scales for physical and social anhedonia. J Abnorm Psychol 85:374,1976.
- Published
- 1997
40. Cisplatin-induced DNA-platination in experimental dorsal root ganglia neuronopathy
- Author
-
Meijer, C., Vries, E. G. E., Marmiroli, P., Tredici, G., Frattola, L., guido cavaletti, Meijer, C, de Vries, E, Marmiroli, P, Tredici, G, Frattola, L, Cavaletti, G, and Guided Treatment in Optimal Selected Cancer Patients (GUTS)
- Subjects
inorganic chemicals ,TISSUES ,Time Factors ,Time Factor ,Antibodie ,Neural Conduction ,Sensation Disorder ,Antineoplastic Agents ,Kidney ,Antibodies ,Antineoplastic Agent ,DNA Adducts ,ADDUCTS ,Neurotoxicity Syndrome ,Ganglia, Spinal ,SPINAL GANGLIA ,Animals ,Rats, Wistar ,neoplasms ,Pt-DNA adducts ,Pain Measurement ,PLATINUM ,Neurons ,Animal ,dorsal root ganglia ,MICROSCOPY ,Neuron ,Immunohistochemistry ,female genital diseases and pregnancy complications ,Rats ,DNA Adduct ,Disease Models, Animal ,NEUROTOXICITY ,Sensation Disorders ,Rat ,Female ,Neurotoxicity Syndromes ,Cisplatin ,RESISTANCE - Abstract
The mechanism(s) and site(s) of the neurotoxic effect of cisplatin (CDDP) are still not entirely elucidated. A more detailed knowledge of these aspects of CDDP treatment might be useful to obtain a better understanding of the pathogenesis of its peripheral neurotoxicity, which is the dose-limiting side effect of CDDP. In the present study, the occurrence of CDDP-induced DNA-platination in dorsal root ganglia (DRG) of rats was evaluated in relation to DRG neuron pathological changes and CDDP-induced neuronopathy. Eight adult Wistar rats were treated with 2 mg/kg ip CDDP twice weekly for 9 times to induce sensory peripheral neuropathy. DNA-platination in specimens of DRG and kidney was measured immunohistochemically, with a polyclonal antibody (GPt) detecting CDDP-induced Pt-DNA adducts. Results were compared with those of untreated rats. Chronic CDDP-induced neurotoxicity, in a well described experimental model of chronic CDDP neurotoxicity in the Wistar rat, was confirmed by sensory DRG neuronopathy with secondary neuropathy, and demonstrated by reduced pain detection, decreased nerve conduction velocity in the tail nerve as well as morphological and morphometric changes in DRG neurons. Nuclear immunostaining for Pt-DNA adducts was observed in tubular cells of the kidney in 75% of the evaluated CDDP-treated rats, while in DRG cells CDDP-induced Pt-DNA adducts formation was found in 43% of the evaluated CDDP-treated rats. CDDP-induced DNA-platination was demonstrated in rat DRG neurons using a schedule of chronic CDDP administration which induced the onset of a sensory neuronopathy with secondary peripheral neuropathy. This finding further supports the hypothesis that CDDP is neurotoxic because it directly damages the DRG neurons. (C) 1999 Intox Press, Inc.
- Published
- 2000
41. Thalamic dementia: Report of a case due to unilateral paramedian infarct of the left thalamus
- Author
-
Isella, V., Santoro, P., Frattola, L., Ferrarese, C., ILDEBRANDO APPOLLONIO, Isella, V, Santoro, P, Frattola, L, Ferrarese, C, and Appollonio, I
- Subjects
MED/26 - NEUROLOGIA ,thalamus, thalamic dementia, case report, paramedian, stroke - Abstract
Thalamic dementia is an infrequent condition characterized by memory deficits and frontal-like behavioral disturbances which are usually due to bilateral (anterior or paramedian) thalamic lesions of various origin. Cases due to a unilateral infarct have only been reported rarely and are the subject of discussion. Here we describe the case of a 67-year-old man, retired, showing the typical clinical and neuropsychological features of thalamic dementia as a consequence mainly of unilateral infarct of the anterior and paramedian part of the left thalamus. At the onset, the patient presented with transient diplopia and vertigo, drowsiness, severe ideomotor slowing, general disorientation, reduced verbal fluency, and both retro- and anterograde amnesia. The neurological examination at admission also showed mild dysmetria at the right upper limb and unsteady gait. During the following weeks, there was a progressive recovery of retrograde memory and of spatial, temporal and personal orientation; ideomotor slowing and hypersomnia partially abated. Anterograde memory deficits, behavioral disturbances, and changes in personality became prominent. The patient appeared considerably apathetic, and indifferent to the environment and presented with a prevalent anxiety-depression mood state, associated with occasional subeuphoric and jocular attitudes. Formal neuropsychological testing was performed 1 year after the onset of symptoms. The patient appeared distractable and showed moderate reduction of psychomotor speed; he was partially aware of his memory problems, even if unconcerned. Spontaneous speech was poor, but grammatically intact. At the MMSE the patient lost points for time orientation and on recall of three items (corrected total score = 26.5/30). The memory tasks revealed a marked reduction in verbal memory ability; performance at attention and fluency tasks were low-average. There was no evidence of aphasia, apraxia, agnosia, and visuospatial deficits. The Neuropsychiatric Inventory mainly revealed the presence of intense abulia, anxiety and depression, irritability, and dishinibition. Three serial contrasted CT scans, performed during hospitalization, were normal, whereas a subsequent (7 months later) brain MRI showed an infarct involving the anterior and paramedian part of the left thalamus and lacunar lesions located in the lenticular nuclei and in the cerebellar hemispheres bilaterally. The present report contributes to the clarification of organization and physiology of thalamus and thalamocortical pathways involved in memory and behavior dynamics.
- Published
- 2000
42. Mitsuyama variant in the association ALS-dementia
- Author
-
ILDEBRANDO APPOLLONIO, Cavarretta, R., Melzi, P., Apale, P., Curtò, N., Frattola, L., Appollonio, I, Cavarretta, R, Melzi, P, Apale, P, Curtò, N, and Frattola, L
- Subjects
MED/26 - NEUROLOGIA ,Mitsuyama variant, ALS, amiotrphic lateral sclerosis, dementia ,MED/09 - MEDICINA INTERNA - Abstract
Mitsuyama variant in the association ALS-dementia. We report a case characterized by the association of an early-onset, rapidly progressive and severe dementia with the subsequent appearance of a motoneuron disease (bulbar ALS). The neuropsychological evaluation showed a global cognitive impairment, with a more profound impairment of executive, linguistic and mnestic functions, as in fronto-temporal dementia. SPECT and PET investigations demonstrated a bilateral reduction of blood perfusion and glucose metabolism in the frontal and temporal lobes. Brain MRI showed a diffuse cortical atrophy, more pronounced at the level of the frontal lobes. The characteristics of the present case are in agreement with the clinical variant first described by Mytsuyama in eastern patients. However, our case differs for the extremely rapid onset and progression of cognitive decline and this could suggest that the complexity of the association between fronto-temporal dementia and ALS is even more heterogeneous than reported up-to-date.
- Published
- 2000
43. Oftalmoplegia dolorosa di Tolosa-Hunt: Sindrome o malattia? Descrizione di caso atipico bilaterale
- Author
-
Riva, R, Appollonio, I, Piolti, R, Frattola, L, APPOLLONIO, ILDEBRANDO, Frattola, L., Riva, R, Appollonio, I, Piolti, R, Frattola, L, APPOLLONIO, ILDEBRANDO, and Frattola, L.
- Abstract
Tolosa-Hunt syndrome is a rare type of painful ophtalmoplegia, almost exclusively monolateral, characterized by a series of clinical criteria; diagnosis is usually reach by an exclusion procedure. New contribution from MRI have recently allowed diagnosis to be based not only on clinical but also on neuroimaging hallmarks. In this article we review the history and the actual knowledge on Tolosa-Hunt syndrome starting from desciption of an unusual case report characterized by a bilateral involvement of the oculomotor nerves., Tolosa-Hunt syndrome is a rare type of painful ophtalmoplegia, almost exclusively monolateral, characterized by a series of clinical criteria; diagnosis is usually reach by an exclusion procedure. New contribution from MRI have recently allowed diagnosis to be based not only on clinical but also on neuroimaging hallmarks. In this article we review the history and the actual knowledge on Tolosa-Hunt syndrome starting from desciption of an unusual case report characterized by a bilateral involvement of the oculomotor nerves.
- Published
- 1996
44. An atypical case of mononeuritis multiplex in primary Sjogren's syndrome
- Author
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Curtò, N, Appollonio, I, Frattola, L, Frattola, L., APPOLLONIO, ILDEBRANDO, Curtò, N, Appollonio, I, Frattola, L, Frattola, L., and APPOLLONIO, ILDEBRANDO
- Abstract
An atypical case of peripheral nervous system (PNS) involvement in Sjogren's syndrome is presented in a 63 year-old woman. Symptoms of an entrapment neuropathy were the first manifestation of the systemic disease and they were subsequently coupled to those of a mononeuritis multiplex. Clinical and laboratory signs for the diagnosis of Sjogren's syndrome became subsequently overt. The mononeuritis multiplex remained clinically limited to the upper limbs and characterized by unusually severe motor symptoms which progressed up to the development of a final complete deplegia. By contrast, sensory symptoms at the upper limbs remained mild over the entire course of the disease and the lower limbs revealed a subclinical sensory-motor damage only during the late stage.
- Published
- 1996
45. Listeria rhombencephalitis: report of two cases with early diagnosis and favourable outcome
- Author
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Bianchi, G, Appollonio, I, Piolti, R, Pozzi, C, Frattola, L, APPOLLONIO, ILDEBRANDO, Frattola, L., Bianchi, G, Appollonio, I, Piolti, R, Pozzi, C, Frattola, L, APPOLLONIO, ILDEBRANDO, and Frattola, L.
- Abstract
We present 2 cases of Listeria monocytogenes rhombencephalitis (L-RE), both affecting previously healthy adult men. Each of them developed a diphasic syndrome first characterized by fever, nausea and headache, followed, in a second phase, by severe brain stem dysfunction at the level of the pons, with meningism, multiple cranial nerve palsies, ataxia, and, in one case, seizures. The early examination of the cerebrospinal fluid (CSF) demonstrated the presence of Gram-positive bacilli whose typical characteristics were compatible with those of Listeria, allowing for immediate administration of a specific therapy. Neuroimaging techniques (either CT or MRI) did not provide any evidence of brain stem involvement, and they did not positively contribute to the diagnostic process. The immediate use of a specific antibiotic therapy led to a favourable clinical outcome for both patients
- Published
- 1995
46. Proglumide, a cholecystokinin receptor antagonist, reduces neuroleptic action in huntington's chorea
- Author
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Piolti, R, Appollonio, I, Perego, M, Pozzi, C, Rovati, L, Ferrarese, C, Frattola, L, Frattola, L., APPOLLONIO, ILDEBRANDO, FERRARESE, CARLO, Piolti, R, Appollonio, I, Perego, M, Pozzi, C, Rovati, L, Ferrarese, C, Frattola, L, Frattola, L., APPOLLONIO, ILDEBRANDO, and FERRARESE, CARLO
- Abstract
In a pilot study, proglumide, a cholecystokinin receptor antagonist, was administered to 8 patients affected from Huntington's chorea under long-term haloperidol treatment. The effectiveness of haloperidol on chronic symptomatology was reduced by the concomitant administration of proglumide; the latter drug, when administered alone, did not modify the severity of chorea compared to placebo. Possible explanations of these results are discussed, stressing the modulatory role of CCK not only on the dopaminergic, but also on the GABAergic system.
- Published
- 1995
47. Antiarrhythmic drugs and polyneuropathy
- Author
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Beghi, E, Monticelli, Ml, Bono, A, Bogliun, G, Curto, N, Marzorati, L, Frattola, L, Achilli, F, Bozzano, A, Cadel, A, Cazzaniga, A, Pria, B, Vincenti, A, Chianale, G, Demattei, M, Zaina, P, Colivicchi, F, Fanelli, R, Mignogna, T, Ciervo, A, Tonali, P, Bellocci, Fulvio, Diviesti, P, Simone, P, Zarrelli, M, Lanna, P, Potenza, D, Fenici, Riccardo, Melillo, G, Gaita, F, Giosetto, C, Magi, S, Monticelli,Ml, Bono,A, Bogliun,G, Curto,N, Frattola,L, Achilli,F, Bozzano,A, Cadel,A, Cazzaniga,A, Pria,B, Chianale,G, Demattei,M, Zaina,P, Colivicchi,F, Fanelli,R, Mignogna,T, Ciervo,A, Diviesti,P, Zarrelli,M, Lanna,P, Potenza,D, Fenici, Riccardo (ORCID:0000-0002-4664-2653), Melillo,G, Gaita,F, Giosetto,C, Magi,S, Beghi, E, Monticelli, Ml, Bono, A, Bogliun, G, Curto, N, Marzorati, L, Frattola, L, Achilli, F, Bozzano, A, Cadel, A, Cazzaniga, A, Pria, B, Vincenti, A, Chianale, G, Demattei, M, Zaina, P, Colivicchi, F, Fanelli, R, Mignogna, T, Ciervo, A, Tonali, P, Bellocci, Fulvio, Diviesti, P, Simone, P, Zarrelli, M, Lanna, P, Potenza, D, Fenici, Riccardo, Melillo, G, Gaita, F, Giosetto, C, Magi, S, Monticelli,Ml, Bono,A, Bogliun,G, Curto,N, Frattola,L, Achilli,F, Bozzano,A, Cadel,A, Cazzaniga,A, Pria,B, Chianale,G, Demattei,M, Zaina,P, Colivicchi,F, Fanelli,R, Mignogna,T, Ciervo,A, Diviesti,P, Zarrelli,M, Lanna,P, Potenza,D, Fenici, Riccardo (ORCID:0000-0002-4664-2653), Melillo,G, Gaita,F, Giosetto,C, and Magi,S
- Abstract
A total of 151 patients on chronic treatment with amiodarone and other antiarrhythmic drugs were subjected to standard clinical and electrophysiological investigation to assess the prevalence and specificity of polyneuropathy. Twenty two untreated patients with cardiac disorders and 246 normal subjects served as controls. Abnormal electrophysiological findings supporting the diagnosis of polyneuropathy were present in 38 subjects (25%) given antiarrhythmic drugs, with even distribution among drugs, and four untreated patients (18%). Concurrent clinical abnormalities were present in five treated patients (one each with amiodarone, propafenone, and flecainide, and two with multiple drugs). Therefore, electrophysiological abnormalities are a common, although non-specific, feature in patients taking antiarrhythmic drugs. Amiodarone users do not seem at higher risk of polyneuropathy than subjects treated with other drugs or even untreated patients with cardiac disorders
- Published
- 1994
48. Assessment of reliability and biological significance of glutamate levels in cerebrospinal fluid
- Author
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Ferrarese, C, Pecora, N, Frigo, M, Appollonio, I, Frattola, L, FERRARESE, CARLO, PECORA, NICOLETTA, APPOLLONIO, ILDEBRANDO, Frattola, L., Ferrarese, C, Pecora, N, Frigo, M, Appollonio, I, Frattola, L, FERRARESE, CARLO, PECORA, NICOLETTA, APPOLLONIO, ILDEBRANDO, and Frattola, L.
- Abstract
The published information on glutamate levels in cerebrospinal fluid (CSF) and modifications in neurological disorders is controversial. In the present study, we demonstrated a metabolic instability of glutamate in untreated CSF and a spurious elevation of its levels by the current methods of CSF acidification. These findings may explain the discrepancies observed with different methods of CSF processing and analysis. We suggest a method of inactivating CSF enzymes that yields stable glutamate levels under different storage conditions. Use of such a method may be necessary for clinical studies.
- Published
- 1993
49. Benzodiazepine receptors and diazepam binding inhibitor: a possible link between stress, anxiety and the immune system
- Author
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Ferrarese, C, Appollonio, I, Bianchi, G, Frigo, M, Marzorati, C, Pecora, N, Perego, M, Pierpaoli, C, Frattola, L, FERRARESE, CARLO, APPOLLONIO, ILDEBRANDO, PECORA, NICOLETTA, Frattola, L., Ferrarese, C, Appollonio, I, Bianchi, G, Frigo, M, Marzorati, C, Pecora, N, Perego, M, Pierpaoli, C, Frattola, L, FERRARESE, CARLO, APPOLLONIO, ILDEBRANDO, PECORA, NICOLETTA, and Frattola, L.
- Abstract
This review summarizes the evidence available on the involvement in stress of different classes of benzodiazepine receptors and their putative endogenous ligand, diazepam binding inhibitor (DBI), with particular reference to their role in modifications of the immune response. The presented data from in vitro, experimental, and clinical studies suggest that benzodiazepine receptors and DBI play a major role in regulating steroid production in both the adrenals and central nervous system, and may be involved in the activation of the hypothalamic-pituitary-adrenal axis in stress response.
- Published
- 1993
50. Antiepileptic drugs and peripheral nerve function: a multicenter screening investigation of 141 patients with chronic treatment. Collaborative Group for the Study of Epilepsy
- Author
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Bono, A, Beghi, E, Bogliun, G, Cavaletti, G, Curtó, N, Marzorati, L, Frattola, L, Frattola, L., CAVALETTI, GUIDO ANGELO, Bono, A, Beghi, E, Bogliun, G, Cavaletti, G, Curtó, N, Marzorati, L, Frattola, L, Frattola, L., and CAVALETTI, GUIDO ANGELO
- Abstract
One hundred forty-one adult patients treated for no less than 6 months with standard daily doses of the commonest antiepileptic drugs (AEDs) were recruited in five Italian centers and submitted to intensive clinical and electrophysiologic investigation to assess the effects of AEDs on peripheral nerves. Eighty percent of the patients were receiving monotherapy. Carbamazepine (CBZ) was the most common AED (51 cases), followed by phenytoin (PHT) (46), phenobarbital (PB) (42), and valproate (VPA) (25). Fifty-three percent of the patients had one or more symptoms of polyneuropathy (paresthesias being the most common complaint). The neurologic examination was abnormal in 32%. Electrophysiologic findings in two or more separate nerves were abnormal in 77 patients (54.6%); of these, 27 (19.1%) had abnormal neurologic findings and 21 (14.9%) also had symptoms of polyneuropathy. Sensory functions were most frequently impaired. Sural nerve biopsy was performed in 4 patients receiving monotherapy with CBZ, PHT, PB, and VPA. Except in patients receiving VPA (in whom no morphologic abnormalities were detected), mild predominantly axonal damage with secondary myelin changes was noted. A correlation was noted between polyneuropathy, age of the patient and, to a lesser extent, receipt of two or more AEDs
- Published
- 1993
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