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CASE Cody was always a short child with stature at the 5th percentile of a standard growth curve since he was a toddler. His weight was between the 10th and [...]

We evaluated the efficacy of a depot preparation of growth hormone (GH) in a 15% gelatin solution (GH-gel) in the treatment of 15 growth hormone-deficient children. The studies were designed to see if prolonging absorption of GH to achieve lower more physiological concentrations of GH in plasma would decrease the frequency of injection, reduce the amount of GH needed for effective therapeutic response, and improve the response to long-term treatment. We found that after a single dose of GH-gel the plasma concentrations of GH were lower than those achieved after the standard aqueous preparation. The preparation was efficacious in promoting growth and our 1st study of 6 patients suggested that GH-gel given twice a week had a growth response equal to that of the three-times a week aqueous schedule. However both schedules resulted in the frequently observed decreased growth rate during the second treatment year. Our 2nd study, attempting to ameliorate this waning effect by using the GH-gel preparation twice a week in a weight-adjusted dose during the entire second year did not resolve the problem. Thus, GH in depot gel results in more physiological plasma concentrations of GH and may be beneficial in reducing the quantity of hormone needed and the injection frequency but it does not offer a solution to the waning response to the long-term administration of GH. [ABSTRACT FROM AUTHOR]

Total backscatter-coefficient inversion error bounds for the two-component lidar inversion algorithm (so-called Fernald's or Klett-Fernald-Sasano's method) are derived in analytical form in response to the following three error sources: 1) the measurement noise; 2) the user uncertainty in the backscatter-coefficient calibration; and 3) the aerosol extinction-to-backscatter ratio. The following two different types of error bounds are presented: 1) approximate error bounds using first-order error propagation and 2) exact error bounds using a total-increment method. Both error bounds are formulated in explicit analytical form, which is of advantage for practical physical sensitivity analysis and computational implementation. A Monte Carlo approach is used to validate the error bounds at 355-, 532-, and 1064-nm wavelengths. [ABSTRACT FROM AUTHOR]

The ability of high-resolution imaging systems to resolve small-scale structure on the ocean surface suggests the possibility of using characteristics of Langmuir circulation to map the surface mixed-layer depth and near-surface current. We illustrate this using synthetic aperture radar and infrared imagery that are collected across the edge of the Gulf Stream (GS), which reveals surfactant streaks, or ldquowindrows,rdquo that are induced by Langmuir circulation. Based on changes in the windrow spacing and orientation, the mixed layer is estimated to deepen from 7 to 12 m across the edge of the GS and the current to increase from about 1 to 2 m/s. These spatial changes compare reasonably well with independent data, suggesting that the approach is plausible. It may also be possible to extract additional environmental information from the windrows. [ABSTRACT FROM PUBLISHER]