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4. Ophthalmic and Systemic Factors of Acute Nonarteritic Anterior Ischemic Optic Neuropathy in the Quark207 Treatment Trial

Author

Clare, Fraser, Celia, Chen, Neil, Shuey, Stephen, Colley, Wang, Ningli, Dou, Hongliang, Zhong, Yong, Tang, Luosheng, Han, Quanhong, Dirk, Sandner, Maria-Andreea, Gamulescu, Nicole, Eter, Helmut, Wilhelm, Katrin, Lorenz, Santhosh, Krishna G., Ramesh, Kekunnaya, S, Ambika, Kumudini, Sharma, Warkad, Vivekanand Uttamrao, Rohit, Saxena, Mahesh, Kumar S., Dipankar, Das, Atul, Hegade, Shahana, Mazumdar, Sachin, Daighavane, Virender, Sachdeva, Hadas, Kalish, Ainat, Klein, Ruth, Huna-Baron, Hana, Leiba, Nitza, Goldenberg-Cohen, Marina, Shneck, Joshua, Kruger, Pasquale, Ciardella Antonio, Gianni, Virgili, Arturo, Carta, Stefania, Bianchi Marzoli, Tow, Sharon, Fang, Chin Chee, Peter, MacIntosh, Jeffrey, Bennett, Byron, Lam, Bradley, Katz, Zoe, Williams, Michael, Lee, Madhura, Tamhankar, Rudrani, Banik, Michael, Rauser, Marc, Levy, Joyce, Liao Yaping, James, Luu, Michael, Tibbetts, David, Scales, Robert, Lesser, Anil, Patel, Syndee, Givre, Gregory, Van Stavern, Steven, Hamilton, Vivian, Rismondo, Courtney, Francis, Dean, Cestari, Marc, Dinkin, John, Pula, Padmaja, Sudhakar, Steven, Newman, Rosa, Tang, Joseph, Chacko, Sachin, Kedar, Peter, Quiros, Larry, Frohman, Nicholas, Volpe, Patrick, Sibony, John, Chen, Luis, Mejico, Gregory, Kosmorsky, Virgil, Alfaro Daniel, David, Katz, Andrew, Lee, Lindsey, DeLott, Vivek, Patel, Swaraj, Bose, Crandall, Peeler, Bhatti, Tariq, Kupersmith, Mark J., Fraser, Clare L., Morgenstern, Rachelle, Miller, Neil R., Levin, Leonard A., and Jette, Nathalie

Published
2024
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5. Application of a Deep Learning System to Detect Papilledema on Nonmydriatic Ocular Fundus Photographs in an Emergency Department

Author

Fraser, Clare L., Micieli, Jonathan A., Costello, Fiona, Bénard-Séguin, Étienne, Yang, Hui, Chan, Carmen Kar Mun, Cheung, Carol Y, Chan, Noel CY, Hamann, Steffen, Gohier, Philippe, Vautier, Anaïs, Rougier, Marie-Bénédicte, Chiquet, Christophe, Vignal-Clermont, Catherine, Hage, Rabih, Khanna, Raoul Kanav, Tran, Thi Ha Chau, Lagrèze, Wolf Alexander, Jonas, Jost B, Ambika, Selvakumar, Fard, Masoud Aghsaei, La Morgia, Chiara, Carbonelli, Michele, Barboni, Piero, Carelli, Valerio, Romagnoli, Martina, Amore, Giulia, Nakamura, Makoto, Fumio, Takano, Petzold, Axel, Wenniger lj, Maillette de Buy, Kho, Richard, Fonseca, Pedro L., Bikbov, Mukharram M., Milea, Dan, Najjar, Raymond P, Ting, Daniel, Tang, Zhiqun, Loo, Jing Liang, Tow, Sharon, Singhal, Shweta, Vasseneix, Caroline, Wong, Tien Yin, Lamoureux, Ecosse, Yu Chen, Ching, Aung, Tin, Schmetterer, Leopold, Sanda, Nicolae, Thuman, Gabriele, Hwang, Jeong-Min, Vanikieti, Kavin, Suwan, Yanin, Padungkiatsagul, Tanyatuth, Yu-Wai-Man, Patrick, Jurkute, Neringa, Hong, Eun Hee, Biousse, Valerie, Newman, Nancy J., Peragallo, Jason H., Datillo, Michael, Kedar, Sachin, Lin, Mung Yan, Patil, Ajay, Aung, Andre, Boyko, Matthew, Alsakran, Wael Abdulraman, Zayani, Amani, Bouthour, Walid, Banc, Ana, Mosley, Rasha, Labella, Fernando, Miller, Neil R., Chen, John J., Mejico, Luis J., Kilangalanga, Janvier Ngoy, Biousse, Valérie, Najjar, Raymond P., Wright, David W., Keadey, Matthew T., Wong, Tien Y., and Bruce, Beau B.

Published
2024
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7. The BONSAI (Brain and Optic Nerve Study with Artificial Intelligence) deep learning system can accurately identify pediatric papilledema on standard ocular fundus photographs

Author

Fraser, Clare L., Micieli, Jonathan A., Costello, Fiona, Étienne Bénard-Séguin, Yang, Hui, Mun Chan, Carmen Kar, Cheung, Carol Y., Chan, Noel CY., Hamann, Steffen, Gohier, Philippe, Vautier, Anaïs, Rougier, Marie-Bénédicte, Chiquet, Christophe, Vignal-Clermont, Catherine, Hage, Rabih, Khanna, Raoul Kanav, Chau Tran, Thi Ha, Lagrèze, Wolf Alexander, Jonas, Jost B., Ambika, Selvakumar, Fard, Masoud Aghsaei, La Morgia, Chiara, Carbonelli, Michele, Barboni, Piero, Carelli, Valerio, Romagnoli, Martina, Amore, Giulia, Nakamura, Makoto, Fumio, Takano, Petzold, Axel, de Buy Wenniger L.J., Maillette, Kho, Richard, Fonseca, Pedro L., Bikbov, Mukharram M., Milea, Dan, Najjar, Raymond P., Ting, Daniel, Tang, Zhiqun, Loo, Jing Liang, Tow, Sharon, Singhal, Shweta, Vasseneix, Caroline, Wong, Tien Yin, Lamoureux, Ecosse, Chen, Ching Yu, Aung, Tin, Schmetterer, Leopold, Sanda, Nicolae, Thuman, Gabriele, Hwang, Jeong-Min, Vanikieti, Kavin, Suwan, Yanin, Padungkiatsagul, Tanyatuth, Yu-Wai-Man, Patrick, Jurkute, Neringa, Hong, Eun Hee, Biousse, Valerie, Newman, Nancy J., Peragallo, Jason H., Datillo, Michael, Kedar, Sachin, Lin, Mung Yan, Patil, Ajay, Aung, Andre, Boyko, Matthew, Alsakran, Wael Abdulraman, Zayani, Amani, Bouthour, Walid, Banc, Ana, Mosley, Rasha, Labella, Fernando, Miller, Neil R., Chen, John J., Mejico, Luis J., Kilangalanga, Janvier Ngoy, Cioplean, Daniela, Dragomir, Mihaela, Chia, Audrey, and Biousse, Valérie

Published
2024
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9. Diagnosis and classification of optic neuritis

Author

Petzold, Axel, Fraser, Clare L, Abegg, Mathias, Alroughani, Raed, Alshowaeir, Daniah, Alvarenga, Regina, Andris, Cécile, Asgari, Nasrin, Barnett, Yael, Battistella, Roberto, Behbehani, Raed, Berger, Thomas, Bikbov, Mukharram M, Biotti, Damien, Biousse, Valerie, Boschi, Antonella, Brazdil, Milan, Brezhnev, Andrei, Calabresi, Peter A, Cordonnier, Monique, Costello, Fiona, Cruz, Franz M, Cunha, Leonardo Provetti, Daoudi, Smail, Deschamps, Romain, de Seze, Jerome, Diem, Ricarda, Etemadifar, Masoud, Flores-Rivera, Jose, Fonseca, Pedro, Frederiksen, Jette, Frohman, Elliot, Frohman, Teresa, Tilikete, Caroline Froment, Fujihara, Kazuo, Gálvez, Alberto, Gouider, Riadh, Gracia, Fernando, Grigoriadis, Nikolaos, Guajardo, José M, Habek, Mario, Hawlina, Marko, Martínez-Lapiscina, Elena H, Hooker, Juzar, Hor, Jyh Yung, Howlett, William, Huang-Link, Yumin, Idrissova, Zhannat, Illes, Zsolt, Jancic, Jasna, Jindahra, Panitha, Karussis, Dimitrios, Kerty, Emilia, Kim, Ho Jin, Lagrèze, Wolf, Leocani, Letizia, Levin, Netta, Liskova, Petra, Liu, Yaou, Maiga, Youssoufa, Marignier, Romain, McGuigan, Chris, Meira, Dália, Merle, Harold, Monteiro, Mário L R, Moodley, Anand, Moura, Frederico, Muñoz, Silvia, Mustafa, Sharik, Nakashima, Ichiro, Noval, Susana, Oehninger, Carlos, Ogun, Olufunmilola, Omoti, Afekhide, Pandit, Lekha, Paul, Friedemann, Rebolleda, Gema, Reddel, Stephen, Rejdak, Konrad, Rejdak, Robert, Rodriguez-Morales, Alfonso J, Rougier, Marie-Bénédicte, Sa, Maria Jose, Sanchez-Dalmau, Bernardo, Saylor, Deanna, Shatriah, Ismail, Siva, Aksel, Stiebel-Kalish, Hadas, Szatmary, Gabriella, Ta, Linh, Tenembaum, Silvia, Tran, Huy, Trufanov, Yevgen, van Pesch, Vincent, Wang, An-Guor, Wattjes, Mike P, Willoughby, Ernest, Zakaria, Magd, Zvornicanin, Jasmin, Balcer, Laura, and Plant, Gordon T

Published
2022
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11. Deep Learning System Outperforms Clinicians in Identifying Optic Disc Abnormalities

Author

Vasseneix, Caroline, Nusinovici, Simon, Xu, Xinxing, Hwang, Jeong-Min, Hamann, Steffen, Chen, John J., Loo, Jing Liang, Milea, Leonard, Tan, Kenneth B.K., Ting, Daniel S.W., Liu, Yong, Newman, Nancy J., Biousse, Valerie, Wong, Tien Ying, Milea, Dan, Najjar, Raymond P., Gohier, Philippe, Miller, Neil, Vanikieti, Kavin, La Morgia, Chiara, Rougier, Marie-Bénédicte, Ambika, Selvakumar, Fonseca, Pedro, Lagrèze, Wolf Alexander, Sanda, Nicolae, Chiquet, Christophe, Yang, Hui, Chan, Carmen K. M., Cheung, Carol Y., Ha Chau, Tran Thi, Jurkute, Neringa, Yu-Wai-Man, Patrick, Kho, Richard, Jonas, Jost B, Vignal-Clermont, Catherine, Kim, Dong Hyun, Yang, Hee Kyung, Aung, Tin, Singhal, Shweta, Tow, Sharon, Nongpiur, Monisha Esther, Perera, Shamira, Narayanaswamy, Arun, Thirugnanam, Umapathi N., Fraser, Clare L., Mejico, Luis J., and Fard, Masoud Aghsaei

Published
2023
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12. A headache in the elderly

Author

Lu, Thomas Chengxuan, Firouzbakht, Aryan, Fraser, Clare L, and Phoon, Stephen

Published
2021

13. Application of a Deep Learning System to Detect Papilledema on Nonmydriatic Ocular Fundus Photographs in an Emergency Department

Author

Biousse, Valérie, primary, Najjar, Raymond P., additional, Tang, Zhiqun, additional, Lin, Mung Yan, additional, Wright, David W., additional, Keadey, Matthew T., additional, Wong, Tien Y., additional, Bruce, Beau B., additional, Milea, Dan, additional, Newman, Nancy J., additional, Fraser, Clare L., additional, Micieli, Jonathan A., additional, Costello, Fiona, additional, Bénard-Séguin, Étienne, additional, Yang, Hui, additional, Chan, Carmen Kar Mun, additional, Cheung, Carol Y, additional, Chan, Noel CY, additional, Hamann, Steffen, additional, Gohier, Philippe, additional, Vautier, Anaïs, additional, Rougier, Marie-Bénédicte, additional, Chiquet, Christophe, additional, Vignal-Clermont, Catherine, additional, Hage, Rabih, additional, Khanna, Raoul Kanav, additional, Tran, Thi Ha Chau, additional, Lagrèze, Wolf Alexander, additional, Jonas, Jost B, additional, Ambika, Selvakumar, additional, Fard, Masoud Aghsaei, additional, La Morgia, Chiara, additional, Carbonelli, Michele, additional, Barboni, Piero, additional, Carelli, Valerio, additional, Romagnoli, Martina, additional, Amore, Giulia, additional, Nakamura, Makoto, additional, Fumio, Takano, additional, Petzold, Axel, additional, Wenniger lj, Maillette de Buy, additional, Kho, Richard, additional, Fonseca, Pedro L., additional, Bikbov, Mukharram M., additional, Najjar, Raymond P, additional, Ting, Daniel, additional, Loo, Jing Liang, additional, Tow, Sharon, additional, Singhal, Shweta, additional, Vasseneix, Caroline, additional, Wong, Tien Yin, additional, Lamoureux, Ecosse, additional, Yu Chen, Ching, additional, Aung, Tin, additional, Schmetterer, Leopold, additional, Sanda, Nicolae, additional, Thuman, Gabriele, additional, Hwang, Jeong-Min, additional, Vanikieti, Kavin, additional, Suwan, Yanin, additional, Padungkiatsagul, Tanyatuth, additional, Yu-Wai-Man, Patrick, additional, Jurkute, Neringa, additional, Hong, Eun Hee, additional, Biousse, Valerie, additional, Peragallo, Jason H., additional, Datillo, Michael, additional, Kedar, Sachin, additional, Patil, Ajay, additional, Aung, Andre, additional, Boyko, Matthew, additional, Alsakran, Wael Abdulraman, additional, Zayani, Amani, additional, Bouthour, Walid, additional, Banc, Ana, additional, Mosley, Rasha, additional, Labella, Fernando, additional, Miller, Neil R., additional, Chen, John J., additional, Mejico, Luis J., additional, and Kilangalanga, Janvier Ngoy, additional

Published
2024
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15. A Deep Learning Approach for Accurate Discrimination Between Optic Disc Drusen and Papilledema on Fundus Photographs.

Author

Sathianvichitr, Kanchalika, Najjar, Raymond P., Zhiqun, Tang, Fraser, J. Alexander, Yau, Christine W. L., Girard, Michael J. A., Costello, Fiona, Lin, Mung Y., Lagrèze, Wolf A., Vignal-Clermont, Catherine, Fraser, Clare L., Hamann, Steffen, Newman, Nancy J., Biousse, Valérie, Milea, Dan, Petzold, Axel, Gohier, Philippe, Miller, Neil R., Vanikieti, Kavin, and Milea, Leonard

Abstract

Supplemental Digital Content is Available in the Text. Background: Optic disc drusen (ODD) represent an important differential diagnosis of papilledema caused by intracranial hypertension, but their distinction may be difficult in clinical practice. The aim of this study was to train, validate, and test a dedicated deep learning system (DLS) for binary classification of ODD vs papilledema (including various subgroups within each category), on conventional mydriatic digital ocular fundus photographs collected in a large international multiethnic population. Methods: This retrospective study included 4,508 color fundus images in 2,180 patients from 30 neuro-ophthalmology centers (19 countries) participating in the Brain and Optic Nerve Study with Artificial Intelligence (BONSAI) Group. For training and internal validation, we used 857 ODD images and 3,230 papilledema images, in 1,959 patients. External testing was performed on an independent data set (221 patients), including 207 images with ODD (96 visible and 111 buried), provided by 3 centers of the Optic Disc Drusen Studies Consortium, and 214 images of papilledema (92 mild-to-moderate and 122 severe) from a previously validated study. Results: The DLS could accurately distinguish between all ODD and papilledema (all severities included): area under the receiver operating characteristic curve (AUC) 0.97 (95% confidence interval [CI], 0.96–0.98), accuracy 90.5% (95% CI, 88.0%–92.9%), sensitivity 86.0% (95% CI, 82.1%–90.1%), and specificity 94.9% (95% CI, 92.3%–97.6%). The performance of the DLS remained high for discrimination of buried ODD from mild-to-moderate papilledema: AUC 0.93 (95% CI, 0.90–0.96), accuracy 84.2% (95% CI, 80.2%–88.6%), sensitivity 78.4% (95% CI, 72.2%–84.7%), and specificity 91.3% (95% CI, 87.0%–96.4%). Conclusions: A dedicated DLS can accurately distinguish between ODD and papilledema caused by intracranial hypertension, even when considering buried ODD vs mild-to-moderate papilledema. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Ophthalmic and Systemic Factors of Acute Nonarteritic Anterior Ischemic Optic Neuropathy in the Quark207 Treatment Trial.

Author

Kupersmith, Mark J., Fraser, Clare L., Morgenstern, Rachelle, Miller, Neil R., Levin, Leonard A., and Jette, Nathalie

Subjects
*CARDIOVASCULAR diseases risk factors, *RACE, *CLINICAL trials, *NEUROPATHY, *VISUAL fields
Abstract

We describe the baseline ophthalmic and cardiovascular risk factors across countries, race, and sex for the Quark207 treatment trial for acute nonarteritic anterior ischemic optic neuropathy (NAION). Prospective, randomized controlled clinical trial. Adults 50 to 80 years of age with acute NAION recruited from 80 sites across 8 countries. Ophthalmic features of NAION and cardiovascular risk factors. We evaluated demographics and clinical and ophthalmologic data, including best-corrected visual acuity (BCVA) and average visual field total deviation (TD), in affected eyes and cup-to-disc ratio in fellow eyes at enrollment. We report the prevalence (mean and standard devition, and median and interquartile range [IQR]) of ophthalmic features and cardiovascular risk factors, stratified by country, race, and sex. We corrected for multiple comparisons using Dunn's test with Bonferroni correction for continuous variables and chi-square testing with Holm-Bonferroni correction for categorical variables. The study enrolled 500 men and 229 women with a median age of 60 and 61 years (P = 0.027), respectively. Participants were predominantly White (n = 570) and Asian (n = 149). The study eye BCVA was 71 characters (IQR, 53–84 characters; approximately 0.4 logarithm of the minimum angle of resolution), and the TD was –16.5 dB (IQR, –22.2 to –12.6 dB) for stimulus III and –15.7 dB (IQR, –20.8 to –10.9 dB) for stimulus V. The vertical and horizontal cup-to-disc ratio was 0.1 (IQR, 0.1–0.3) for unaffected fellow eyes. The prevalence of cardiovascular risk factors varied among countries. The most notable differences were in the baseline comorbidities and ophthalmologic features, which differed between Asian and White races. Men and women differed with respect to a few clinically meaningful features. The cardiovascular risk factors in the NAION cohort varied among the 7 countries, race, and sex, but were not typically more prevalent than in the general population. Ophthalmic features, typical of NAION, generally were consistent across countries, race, and sex, except for worse BCVA and TD in China. Men have a frequency of NAION twice that of women. Having a small cup-to-disc ratio in the fellow eye was the most prevalent risk factor across all demographics. This study suggests that factors, not yet identified, may contribute to the development of NAION. Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article. [ABSTRACT FROM AUTHOR]

Published
2024
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18. A case for the use of chemotherapy in hereditary mitochondrial optic neuropathies: Successful administration of cisplatin/etoposide in a male patient with testicular seminoma and Leber's hereditary optic neuropathy.

Author

Vrisakis, Jean‐Luc, Fraser, Clare L., Shahnam, Adel, Nindra, Udit, and Grimison, Peter

Subjects
*LEBER'S hereditary optic atrophy, *SEMINOMA, *CISPLATIN, *MITOCHONDRIA, *CANCER chemotherapy, *NEUROPATHY, *ETOPOSIDE
Abstract

Key Clinical Message: We report on the successful use of chemotherapy for treatment of stage 2B testicular seminoma in a carrier of the Leber's hereditary optic neuropathy 11778 mitochondrial mutation. Neurotoxic chemotherapy may not prompt disease conversion. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Mitochondrial DNA 13513G>A Mutation Causing Leber Hereditary Optic Neuropathy Associated With Adult-Onset Renal Failure.

Author

Swart, Grace, Fraser, Clare L., Shingde, Meena, Thompson, Elizabeth O., Mallawaarachchi, Amali, Lawlor, Mitchell, Ahmad, Kate, Halmagyi, Gabor M., Fraser, Clare, and Mollan, Susan

Abstract

Background: Leber hereditary optic neuropathy (LHON) is one of the more common mitochondrial diseases and is rarely associated with mitochondrial renal disease. We report 3 unrelated patients with a background of adult-onset renal failure who presented to us with LHON and were shown to have a heteroplasmic mitochondrial DNA mutation (m.13513G>A). Methods: Retrospective chart review. Results: All 3 patients had a background of chronic renal failure and presented to us with bilateral optic neuropathy (sequential in 2) and were found to have heteroplasmic m.13513G>A mutations in the MT-ND5 gene. Two of the patients were females (aged 30 and 45 years) with chronic kidney disease from their 20s, attributed to pre-eclampsia, one of whom also had diabetes and sudden bilateral hearing loss. One patient was a male (aged 54 years) with chronic kidney disease from his 20s attributed to IgA nephropathy. His mother had diabetes and apparently sudden bilateral blindness in her 70s. Renal biopsy findings were variable and included interstitial fibrosis, acute tubular necrosis, focal segmental glomerulosclerosis, and IgA/C3 tubular casts on immunofluorescence. Mild improvements in vision followed treatment with either idebenone or a combination supplement including coenzyme Q10, alpha-lipoic acid, and B vitamins. Conclusions: Our cases expand the clinical syndromes associated with m.13513G>A to include bilateral optic neuropathy and adult-onset renal disease. This highlights that in patients with bilateral, especially sequential, optic neuropathy a broad approach to mitochondrial testing is more useful than a limited LHON panel. Mitochondrial diseases present a diagnostic challenge because of their clinical and genetic variability. [ABSTRACT FROM AUTHOR]

Published
2024
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20. SD-OCT Imaging of Macular Changes in Fabry Disease: A Case Report.

Author

Moon, Stephanie S., Ovens, Christopher A., Reid, Gerard, and Fraser, Clare L.

Subjects
ANGIOKERATOMA corporis diffusum, GLYCOGEN storage disease type II, OPTICAL coherence tomography, CHRONIC kidney failure, LYSOSOMAL storage diseases, HEART failure, TREATMENT delay (Medicine)
Abstract

Fabry disease (FD) is a rare, X-linked lysosomal storage disorder that can result in fatal end-stage renal disease, heart failure, and cerebro-occlusive events. Vague clinical symptoms and rarity often mean diagnosis and potential treatment is delayed. Ophthalmic findings in FD patients can be helpful in establishing an early diagnosis and timely treatment. Spectral domain optical coherence tomography (SD-OCT) imaging in FD patients shows hyper-reflective foci (HRF) in characteristic patterns within the inner retinal layers. We found that the HRF was localised in linear distributions at the deep and superficial borders of the retinal inner nuclear layer, likely reflecting anatomic vascular plexuses and FD-related sphingolipid deposition within the vessel walls. These results highlight the potential use of SD-OCT in FD and how it may aid diagnosis in undifferentiated patients, prognostication, and disease monitoring. [ABSTRACT FROM AUTHOR]

Published
2024
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25. PHOMS: An apt and accurate acronym

Author

Liu, Allison, Steensberg, Alvilda Hemmingsen, Gilbert, Aubrey L., Petzold, Axel, Katz, Bradley J., Fraser, Clare L., Milea, Dan, Costello, Fiona, Moss, Heather E., Shin, Hyunjin, Fraser, J. Alexander, Peragallo, Jason H., Gale, Jesse, Warner, Judith E.A., Digre, Kathleen B., Malmqvist, Lasse, Lykkebirk, Lea, Bursztyn, Lulu L.C.D., Rougier, Marie-Bénédicte, Fard, Masoud Aghsaei, El-Dairi, Mays A., Girard, Michael J.A., Lawlor, Mitchell, Rasool, Nailyn, Newman, Nancy J., Jurkute, Neringa, Sibony, Patrick A., Fonseca, Pedro, Quiros, Peter A., Maloca, Peter M., Subramanian, Prem S., Huna-Baron, Ruth, Beres, Shannon J., Bassi, Shikha Talwar, Rothenbuehler, Simon P., Wong, Sui H., Mollan, Susan P., Martín, Susana Noval, Biousse, Valerie, Shah, Veeral S., Liao, Yaping Joyce, Fraser, J.A., Costello, F., and Hamann, S.

Published
2024
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29. Neuro-Ophthalmic Complications in Patients Treated With CTLA-4 and PD-1/PD-L1 Checkpoint Blockade

Author

Sun, Michel M., Seleme, Nicolas, Chen, John J., Zekeridou, Anastasia, Sechi, Elia, Walsh, Ryan D., Beebe, Johanna D., Sabbagh, Osama, Mejico, Luis J., Gratton, Sean, Skidd, Philip M., Bellows, David A., Falardeau, Julie, Fraser, Clare L., Cappelen-Smith, Cecilia, Haines, Scott R., Hassanzadeh, Bahareh, Seay, Meagan D., Subramanian, Prem S., Williams, Zoë, and Gordon, Lynn K.

Published
2020
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31. Guidelines of the International Headache Society for Controlled Clinical Trials in Idiopathic Intracranial Hypertension

Author

Mollan, Susan P., primary, Fraser, Clare L., additional, Digre, Kathleen B., additional, Diener, Hans-Christoph, additional, Lipton, Richard B., additional, Juhler, Marianne, additional, Miller, Neil R., additional, Pozo-Rosich, Patricia, additional, Togha, Mansoureh, additional, Brock, Kristian, additional, Dinkin, Marc J., additional, Chan, Carmen K. M., additional, Tassorelli, Cristina, additional, Sinclair, Alex J., additional, Terwindt, Gisela M., additional, and Jensen, Rigmor H., additional

Published
2023
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34. Real-World Clinical Experience With Idebenone in the Treatment of Leber Hereditary Optic Neuropathy

Author

Catarino, Claudia B., von Livonius, Bettina, Priglinger, Claudia, Banik, Rudrani, Matloob, Selma, Tamhankar, Madhura A., Castillo, Lorena, Friedburg, Christoph, Halfpenny, Christopher A., Lincoln, John A., Traber, Ghislaine L., Acaroglu, Gölge, Black, Graeme C. M., Doncel, Carlos, Fraser, Clare L., Jakubaszko, Joanna, Landau, Klara, Langenegger, Stefan J., Muñoz-Negrete, Francisco J., Newman, Nancy J., Poulton, Joanna, Scoppettuolo, Elisabetta, Subramanian, Prem, Toosy, Ahmed T., Vidal, Mariona, Vincent, Andrea L., Votruba, Marcela, Zarowski, Marcin, Zermansky, Adam, Lob, Felice, Rudolph, Günther, Mikazans, Oskars, Silva, Magda, Llòria, Xavier, Metz, Günther, and Klopstock, Thomas

Published
2020
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35. Globe trauma associated with falls at Australian tertiary centres.

Author

Bartimote, Christopher, Hoskin, Annette K, Fraser, Clare L, and Watson, Stephanie

Subjects
NOSOLOGY, SUBSTANCE abuse, TERTIARY care, RETROSPECTIVE studies, ACQUISITION of data, PATIENTS, OCULAR injuries, HOSPITAL admission & discharge, SEVERITY of illness index, ACCIDENTAL falls, MEDICAL records, MEDICAL referrals, DESCRIPTIVE statistics, OPHTHALMOLOGY, DISEASE risk factors, DISEASE complications, OLD age
Abstract

Objective: Falls frequently cause globe and adnexal trauma, particularly in the elderly. The morbidity decreases confidence, independence and quality of life. We aimed to improve the understanding of fall‐related globe and adnexal trauma and the involvement of ophthalmology at two tertiary trauma centres. Methods: A retrospective medical record review was conducted at Royal North Shore Hospital and Royal Prince Alfred Hospital of patients admitted with fall‐related globe and/or adnexal trauma between January 2015 and December 2019. International Classification of Disease Tenth Revision codes were used to identify patients for inclusion. Medical records were reviewed to extract data on demographics, trauma, ocular examination and referrals to ophthalmology. Results: From January 2015 to December 2019, 346 patients, 186 were female (54%) and median age 76 years (interquartile range 24 years), were admitted to Royal North Shore Hospital and Royal Prince Alfred Hospital with fall‐related globe and/or adnexal trauma. One hundred and twenty‐five (36%) suffered globe trauma with 48 (14%) classified as severe. Patients over 65 years old had at least three risk factors contributing to falls. Alcohol and illicit substances were involved in 20% of falls and occurred predominantly in younger populations. There were significantly more patients with globe trauma if orbital/mid‐facial fractures were present (55% vs 36%, P < 0.001). Conclusion: Fall‐related globe and adnexal trauma were more common in the elderly. Alcohol and illicit substances have a role in falls in younger populations. Thorough ocular assessment is required especially in mid‐facial/orbital trauma to exclude globe trauma. Further, research is required to determine the effect of fall prevention strategies in preventing globe trauma. [ABSTRACT FROM AUTHOR]

Published
2024
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36. New Agents for Treating Dry Eye Syndrome

Author

Skalicky, Simon E., Petsoglou, Con, Gurbaxani, Avinash, Fraser, Clare L., McCluskey, Peter, Armstrong, Donald, Editor-in-chief, Babizhayev, Mark A., editor, Li, David Wan-Cheng, editor, Kasus-Jacobi, Anne, editor, Žorić, Lepša, editor, and Alió, Jorge L., editor

Published
2015
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39. Guidelines of the International Headache Society for Controlled Clinical Trials in Idiopathic Intracranial Hypertension

Author

Mollan, Susan P., Fraser, Clare L., Digre, Kathleen B., Diener, Hans Christoph, Lipton, Richard B., Juhler, Marianne, Miller, Neil R., Pozo-Rosich, Patricia, Togha, Mansoureh, Brock, Kristian, Dinkin, Marc J., Chan, Carmen K.M., Tassorelli, Cristina, Sinclair, Alex J., Terwindt, Gisela M., Jensen, Rigmor H., Mollan, Susan P., Fraser, Clare L., Digre, Kathleen B., Diener, Hans Christoph, Lipton, Richard B., Juhler, Marianne, Miller, Neil R., Pozo-Rosich, Patricia, Togha, Mansoureh, Brock, Kristian, Dinkin, Marc J., Chan, Carmen K.M., Tassorelli, Cristina, Sinclair, Alex J., Terwindt, Gisela M., and Jensen, Rigmor H.

Abstract

The quality of clinical trials is essential to advance treatment, inform regulatory decisions and meta-analysis. With the increased incidence of idiopathic intracranial hypertension and the emergence of clinical trials for novel therapies in this condition, the International Headache Society Guidelines for Controlled Clinical Trials in Idiopathic Intracranial Hypertension aims to establish guidelines for designing state-of-the-art controlled clinical trials for idiopathic intracranial hypertension., The quality of clinical trials is essential to advance treatment, inform regulatory decisions and meta-analysis. With the increased incidence of idiopathic intracranial hypertension and the emergence of clinical trials for novel therapies in this condition, the International Headache Society Guidelines for Controlled Clinical Trials in Idiopathic Intracranial Hypertension aims to establish guidelines for designing state-of-the-art controlled clinical trials for idiopathic intracranial hypertension.

Published
2023

46. Characterization of the human myelin oligodendrocyte glycoprotein antibody response in demyelination

Author

Tea, Fiona, Lopez, Joseph A., Ramanathan, Sudarshini, Merheb, Vera, Lee, Fiona X. Z., Zou, Alicia, Pilli, Deepti, Patrick, Ellis, van der Walt, Anneke, Monif, Mastura, Tantsis, Esther M., Yiu, Eppie M., Vucic, Steve, Henderson, Andrew P. D., Fok, Anthony, Fraser, Clare L., Lechner-Scott, Jeanette, Reddel, Stephen W., Broadley, Simon, Barnett, Michael H., Brown, David A., Lunemann, Jan D., Dale, Russell C., Brilot, Fabienne, and the Australasian and New Zealand MOG Study Group

Published
2019
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47. Is the disease risk and penetrance in Leber hereditary optic neuropathy actually low?

Author

Mackey, David A., primary, Ong, Jue-Sheng, additional, MacGregor, Stuart, additional, Whiteman, David C., additional, Craig, Jamie E., additional, Lopez Sanchez, M. Isabel G., additional, Kearns, Lisa S., additional, Staffieri, Sandra E., additional, Clarke, Linda, additional, McGuinness, Myra B., additional, Meteoukki, Wafaa, additional, Samuel, Sona, additional, Ruddle, Jonathan B., additional, Chen, Celia, additional, Fraser, Clare L., additional, Harrison, John, additional, Howell, Neil, additional, and Hewitt, Alex W., additional

Published
2023
Full Text
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