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1. Normal Routine Spirometry Can Mask COPD/Emphysema in Symptomatic Smokers.

Author

Gelb, Arthur F, Yamamoto, Alfred, Verbeken, Eric K, Hogg, James C, Tashkin, Donald P, Tran, Diem NT, Moridzadeh, Roxanna M, Fraser, Christine, Schein, Mark J, Decramer, Marc, Glassy, Eric F, and Nadel, Jay A

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Chronic Obstructive Pulmonary Disease, Biomedical Imaging, Lung, Clinical Research, Tobacco Smoke and Health, Tobacco, Emphysema, Respiratory, COPD, FEF75%, emphysema, small airways obstruction, spirometry
Abstract

Recent studies have emphasized the difficulty of early detection of chronic obstructive pulmonary disease (COPD) in symptomatic smokers with normal routine spirometry. This includes post-bronchodilator normal forced expiratory volume in 1 second (FEV1)(L)≥80% predicted, forced vital capacity (FVC)(L)≥80% predicted, and FEV1/FVC ≥70% or greater than age corrected lower limit of normal (LLN). However, in COPD the pathologic site of small airway obstruction and emphysema begins in the small peripheral airways ≤2 mm id which normally contribute

Published
2021

2. Genome-wide association study identifies 30 loci associated with bipolar disorder

Author

Stahl, Eli A, Breen, Gerome, Forstner, Andreas J, McQuillin, Andrew, Ripke, Stephan, Trubetskoy, Vassily, Mattheisen, Manuel, Wang, Yunpeng, Coleman, Jonathan RI, Gaspar, Héléna A, de Leeuw, Christiaan A, Steinberg, Stacy, Pavlides, Jennifer M Whitehead, Trzaskowski, Maciej, Byrne, Enda M, Pers, Tune H, Holmans, Peter A, Richards, Alexander L, Abbott, Liam, Agerbo, Esben, Akil, Huda, Albani, Diego, Alliey-Rodriguez, Ney, Als, Thomas D, Anjorin, Adebayo, Antilla, Verneri, Awasthi, Swapnil, Badner, Judith A, Bækvad-Hansen, Marie, Barchas, Jack D, Bass, Nicholas, Bauer, Michael, Belliveau, Richard, Bergen, Sarah E, Pedersen, Carsten Bøcker, Bøen, Erlend, Boks, Marco P, Boocock, James, Budde, Monika, Bunney, William, Burmeister, Margit, Bybjerg-Grauholm, Jonas, Byerley, William, Casas, Miquel, Cerrato, Felecia, Cervantes, Pablo, Chambert, Kimberly, Charney, Alexander W, Chen, Danfeng, Churchhouse, Claire, Clarke, Toni-Kim, Coryell, William, Craig, David W, Cruceanu, Cristiana, Curtis, David, Czerski, Piotr M, Dale, Anders M, de Jong, Simone, Degenhardt, Franziska, Del-Favero, Jurgen, DePaulo, J Raymond, Djurovic, Srdjan, Dobbyn, Amanda L, Dumont, Ashley, Elvsåshagen, Torbjørn, Escott-Price, Valentina, Fan, Chun Chieh, Fischer, Sascha B, Flickinger, Matthew, Foroud, Tatiana M, Forty, Liz, Frank, Josef, Fraser, Christine, Freimer, Nelson B, Frisén, Louise, Gade, Katrin, Gage, Diane, Garnham, Julie, Giambartolomei, Claudia, Pedersen, Marianne Giørtz, Goldstein, Jaqueline, Gordon, Scott D, Gordon-Smith, Katherine, Green, Elaine K, Green, Melissa J, Greenwood, Tiffany A, Grove, Jakob, Guan, Weihua, Guzman-Parra, José, Hamshere, Marian L, Hautzinger, Martin, Heilbronner, Urs, Herms, Stefan, Hipolito, Maria, Hoffmann, Per, Holland, Dominic, Huckins, Laura, Jamain, Stéphane, Johnson, Jessica S, and Juréus, Anders

Subjects
Biological Sciences, Genetics, Serious Mental Illness, Mental Health, Human Genome, Brain Disorders, Schizophrenia, Aetiology, 2.1 Biological and endogenous factors, Mental health, Bipolar Disorder, Case-Control Studies, Depressive Disorder, Major, Female, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Male, Polymorphism, Single Nucleotide, Psychotic Disorders, Systems Biology, eQTLGen Consortium, BIOS Consortium, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Medical and Health Sciences, Developmental Biology, Agricultural biotechnology, Bioinformatics and computational biology
Abstract

Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide association study (GWAS) including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 822 variants with P

Published
2019

3. The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls

Author

Byrne, Enda M., Forstner, Andreas J., Holmans, Peter A., de Leeuw, Christiaan A., Mattheisen, Manuel, McQuillin, Andrew, Whitehead Pavlides, Jennifer M., Pers, Tune H., Ripke, Stephan, Stahl, Eli A., Steinberg, Stacy, Trubetskoy, Vassily, Trzaskowski, Maciej, Wang, Yunpeng, Abbott, Liam, Abdellaoui, Abdel, Adams, Mark J., Adolfsson, Annelie Nordin, Agerbo, Esben, Akil, Huda, Albani, Diego, Alliey-Rodriguez, Ney, Als, Thomas D., Andlauer, Till F.M., Anjorin, Adebayo, Antilla, Verneri, Van der Auwera, Sandra, Awasthi, Swapnil, Bacanu, Silviu-Alin, Badner, Judith A., Bækvad-Hansen, Marie, Barchas, Jack D., Bass, Nicholas, Bauer, Michael, Beekman, Aartjan T.F., Belliveau, Richard, Bergen, Sarah E., Bigdeli, Tim B., Binder, Elisabeth B., Bøen, Erlend, Boks, Marco, Boocock, James, Budde, Monika, Bunney, William, Burmeister, Margit, Buttenschøn, Henriette N., Bybjerg-Grauholm, Jonas, Byerley, William, Cai, Na, Casas, Miquel, Castelao, Enrique, Cerrato, Felecia, Cervantes, Pablo, Chambert, Kimberly, Charney, Alexander W., Chen, Danfeng, Christensen, Jane Hvarregaard, Churchhouse, Claire, St Clair, David, Clarke, Toni-Kim, Colodro-Conde, Lucía, Coryell, William, Couvy-Duchesne, Baptiste, Craig, David W., Crawford, Gregory E., Cruceanu, Cristiana, Czerski, Piotr M., Dale, Anders M., Davies, Gail, Deary, Ian J., Degenhardt, Franziska, Del-Favero, Jurgen, DePaulo, J Raymond, Derks, Eske M., Direk, Nese, Djurovic, Srdjan, Dobbyn, Amanda L., Dolan, Conor V., Dumont, Ashley, Dunn, Erin C., Eley, Thalia C., Elvsåshagen, Torbjørn, Escott-Price, Valentina, Fan, Chun Chieh, Finucane, Hilary K., Fischer, Sascha B., Flickinger, Matthew, Foo, Jerome C., Foroud, Tatiana M., Forty, Liz, Frank, Josef, Fraser, Christine, Freimer, Nelson B., Frisén, Louise, Gade, Katrin, Gage, Diane, Garnham, Julie, Giambartolomei, Claudia, Goes, Fernando S., Goldstein, Jaqueline, Gordon, Scott D., Gordon-Smith, Katherine, Green, Elaine K., Green, Melissa J., Greenwood, Tiffany A., Grove, Jakob, Guan, Weihua, Hall, Lynsey S., Hamshere, Marian L., Hansen, Christine Søholm, Hansen, Thomas F., Hautzinger, Martin, Heilbronner, Urs, van Hemert, Albert M., Herms, Stefan, Hickie, Ian B., Hipolito, Maria, Hoffmann, Per, Holland, Dominic, Homuth, Georg, Horn, Carsten, Hottenga, Jouke-Jan, Huckins, Laura, Ising, Marcus, Jamain, Stéphane, Jansen, Rick, Johnson, Jessica S., de Jong, Simone, Jorgenson, Eric, Juréus, Anders, Kandaswamy, Radhika, Karlsson, Robert, Kennedy, James L., Hassan Kiadeh, Farnush Farhadi, Kittel-Schneider, Sarah, Knowles, James A., Kogevinas, Manolis, Kohane, Isaac S., Koller, Anna C., Kraft, Julia, Kretzschmar, Warren W., Krogh, Jesper, Kupka, Ralph, Kutalik, Zoltán, Lavebratt, Catharina, Lawrence, Jacob, Lawson, William B., Leber, Markus, Lee, Phil H., Levy, Shawn E., Li, Jun Z., Li, Yihan, Lind, Penelope A., Liu, Chunyu, Olde Loohuis, Loes M., Maaser, Anna, MacIntyre, Donald J., MacKinnon, Dean F., Mahon, Pamela B., Maier, Wolfgang, Maier, Robert M., Marchini, Jonathan, Martinsson, Lina, Mbarek, Hamdi, McCarroll, Steve, McGrath, Patrick, McGuffin, Peter, McInnis, Melvin G., McKay, James D., Medeiros, Helena, Medland, Sarah E., Mehta, Divya, Meng, Fan, Middeldorp, Christel M., Mihailov, Evelin, Milaneschi, Yuri, Milani, Lili, Mirza, Saira Saeed, Mondimore, Francis M., Montgomery, Grant W., Morris, Derek W., Mostafavi, Sara, Mühleisen, Thomas W., Mullins, Niamh, Nauck, Matthias, Ng, Bernard, Nguyen, Hoang, Nievergelt, Caroline M., Nivard, Michel G., Nwulia, Evaristus A., Nyholt, Dale R., O'Donovan, Claire, O'Reilly, Paul F., Ori, Anil P.S., Oruc, Lilijana, Ösby, Urban, Oskarsson, Hogni, Painter, Jodie N., Parra, José Guzman, Pedersen, Carsten Bøcker, Pedersen, Marianne Giørtz, Perry, Amy, Peterson, Roseann E., Pettersson, Erik, Peyrot, Wouter J., Pfennig, Andrea, Pistis, Giorgio, Purcell, Shaun M., Quiroz, Jorge A., Qvist, Per, Regeer, Eline J., Reif, Andreas, Reinbold, Céline S., Rice, John P., Riley, Brien P., Rivas, Fabio, Rivera, Margarita, Roussos, Panos, Ruderfer, Douglas M., Ryu, Euijung, Sánchez-Mora, Cristina, Schatzberg, Alan F., Scheftner, William A., Schoevers, Robert, Schork, Nicholas J., Schulte, Eva C., Shehktman, Tatyana, Shen, Ling, Shi, Jianxin, Shilling, Paul D., Shyn, Stanley I., Sigurdsson, Engilbert, Slaney, Claire, Smeland, Olav B., Smit, Johannes H., Smith, Daniel J., Sobell, Janet L., Spijker, Anne T., Steffens, Michael, Strauss, John S., Streit, Fabian, Strohmaier, Jana, Szelinger, Szabolcs, Tansey, Katherine E., Teismann, Henning, Teumer, Alexander, Thompson, Robert C., Thompson, Wesley, Thomson, Pippa A., Thorgeirsson, Thorgeir E., Traylor, Matthew, Treutlein, Jens, Uitterlinden, André G., Umbricht, Daniel, Vedder, Helmut, Viktorin, Alexander, Visscher, Peter M., Wang, Weiqing, Watson, Stanley J., Webb, Bradley T., Weickert, Cynthia Shannon, Weickert, Thomas W., Weinsheimer, Shantel Marie, Wellmann, Jürgen, Willemsen, Gonneke, Witt, Stephanie H., Wu, Yang, Xi, Hualin S., Xu, Wei, Yang, Jian, Young, Allan H., Zandi, Peter, Zhang, Peng, Zhang, Futao, Zollner, Sebastian, Adolfsson, Rolf, Agartz, Ingrid, Alda, Martin, Arolt, Volker, Backlund, Lena, Baune, Bernhard T., Bellivier, Frank, Berger, Klaus, Berrettini, Wade H., Biernacka, Joanna M., Blackwood, Douglas H.R., Boehnke, Michael, Boomsma, Dorret I., Corvin, Aiden, Craddock, Nicholas, Daly, Mark J., Dannlowski, Udo, Domenici, Enrico, Domschke, Katharina, Esko, Tõnu, Etain, Bruno, Frye, Mark, Fullerton, Janice M., Gershon, Elliot S., de Geus, E.J.C., Gill, Michael, Goes, Fernando, Grabe, Hans J., Grigoroiu-Serbanescu, Maria, Hamilton, Steven P., Hauser, Joanna, Hayward, Caroline, Heath, Andrew C., Hougaard, David M., Hultman, Christina M., Jones, Ian, Jones, Lisa A., Kahn, René S., Kendler, Kenneth S., Kirov, George, Kloiber, Stefan, Landén, Mikael, Leboyer, Marion, Lewis, Glyn, Li, Qingqin S., Lissowska, Jolanta, Lucae, Susanne, Madden, Pamela A.F., Magnusson, Patrik K., Martin, Nicholas G., Mayoral, Fermin, McElroy, Susan L., McIntosh, Andrew M., McMahon, Francis J., Melle, Ingrid, Metspalu, Andres, Mitchell, Philip B., Morken, Gunnar, Mors, Ole, Mortensen, Preben Bo, Müller-Myhsok, Bertram, Myers, Richard M., Neale, Benjamin M., Nimgaonkar, Vishwajit, Nordentoft, Merete, Nöthen, Markus M., O'Donovan, Michael C., Oedegaard, Ketil J., Owen, Michael J., Paciga, Sara A., Pato, Carlos, Pato, Michele T., Pedersen, Nancy L., Penninx, Brenda W.J. H., Perlis, Roy H., Porteous, David J., Posthuma, Danielle, Potash, James B., Preisig, Martin, Ramos-Quiroga, Josep Antoni, Ribasés, Marta, Rietschel, Marcella, Rouleau, Guy A., Schaefer, Catherine, Schalling, Martin, Schofield, Peter R., Schulze, Thomas G., Serretti, Alessandro, Smoller, Jordan W., Stefansson, Hreinn, Stefansson, Kari, Stordal, Eystein, Tiemeier, Henning, Turecki, Gustavo, Uher, Rudolf, Vaaler, Arne E., Vieta, Eduard, Vincent, John B., Völzke, Henry, Weissman, Myrna M., Werge, Thomas, Andreassen, Ole A., Børglum, Anders D., Cichon, Sven, Edenberg, Howard J., Di Florio, Arianna, Kelsoe, John, Levinson, Douglas F., Lewis, Cathryn M., Nurnberger, John I., Ophoff, Roel A., Scott, Laura J., Sklar, Pamela, Sullivan, Patrick F., Wray, Naomi R., Coleman, Jonathan R.I., Gaspar, Héléna A., Bryois, Julien, and Breen, Gerome

Published
2020
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7. Toward Shared Decision-Making in Degenerative Cervical Myelopathy: Protocol for a Mixed Methods Study

Author

Sangeorzan, Irina, primary, Antonacci, Grazia, additional, Martin, Anne, additional, Grodzinski, Ben, additional, Zipser, Carl M, additional, Murphy, Rory K J, additional, Andriopoulou, Panoraia, additional, Cook, Chad E, additional, Anderson, David B, additional, Guest, James, additional, Furlan, Julio C, additional, Kotter, Mark R N, additional, Boerger, Timothy F, additional, Sadler, Iwan, additional, Roberts, Elizabeth A, additional, Wood, Helen, additional, Fraser, Christine, additional, Fehlings, Michael G, additional, Kumar, Vishal, additional, Jung, Josephine, additional, Milligan, James, additional, Nouri, Aria, additional, Martin, Allan R, additional, Blizzard, Tammy, additional, Vialle, Luiz Roberto, additional, Tetreault, Lindsay, additional, Kalsi-Ryan, Sukhvinder, additional, MacDowall, Anna, additional, Martin-Moore, Esther, additional, Burwood, Martin, additional, Wood, Lianne, additional, Lalkhen, Abdul, additional, Ito, Manabu, additional, Wilson, Nicky, additional, Treanor, Caroline, additional, Dugan, Sheila, additional, and Davies, Benjamin M, additional

Published
2023
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8. Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs.

Author

Absher, Devin, Agartz, Ingrid, Akil, Huda, Amin, Farooq, Andreassen, Ole, Anjorin, Adebayo, Anney, Richard, Anttila, Verneri, Arking, Dan, Asherson, Philip, Azevedo, Maria, Backlund, Lena, Badner, Judith, Bailey, Anthony, Banaschewski, Tobias, Barchas, Jack, Barnes, Michael, Barrett, Thomas, Bass, Nicholas, Battaglia, Agatino, Bauer, Michael, Bayés, Mònica, Bellivier, Frank, Bergen, Sarah, Berrettini, Wade, Betancur, Catalina, Bettecken, Thomas, Biederman, Joseph, Binder, Elisabeth, Black, Donald, Blackwood, Douglas, Boehnke, Michael, Boomsma, Dorret, Breen, Gerome, Breuer, René, Bruggeman, Richard, Cormican, Paul, Buccola, Nancy, Buitelaar, Jan, Bunney, William, Buxbaum, Joseph, Byerley, William, Byrne, Enda, Caesar, Sian, Cahn, Wiepke, Cantor, Rita, Casas, Miguel, Chakravarti, Aravinda, Chambert, Kimberly, Choudhury, Khalid, Cichon, Sven, Cloninger, C, Collier, David, Cook, Edwin, Coon, Hilary, Cormand, Bru, Corvin, Aiden, Coryell, William, Craig, David, Craig, Ian, Crosbie, Jennifer, Cuccaro, Michael, Curtis, David, Czamara, Darina, Datta, Susmita, Dawson, Geraldine, Day, Richard, De Geus, Eco, Degenhardt, Franziska, Djurovic, Srdjan, Donohoe, Gary, Doyle, Alysa, Duan, Jubao, Dudbridge, Frank, Duketis, Eftichia, Ebstein, Richard, Edenberg, Howard, Elia, Josephine, Ennis, Sean, Etain, Bruno, Fanous, Ayman, Farmer, Anne, Ferrier, I, Flickinger, Matthew, Fombonne, Eric, Foroud, Tatiana, Frank, Josef, Franke, Barbara, Fraser, Christine, Freedman, Robert, Giegling, Ina, Gill, Michael, Gordon, Scott, Gordon-Smith, Katherine, Green, Elaine, Greenwood, Tiffany, Grice, Dorothy, Gross, Magdalena, Grozeva, Detelina, and Guan, Weihua

Subjects
Adult, Attention Deficit Disorder with Hyperactivity, Bipolar Disorder, Child, Child Development Disorders, Pervasive, Crohn Disease, Depressive Disorder, Major, Genetic Heterogeneity, Genetic Predisposition to Disease, Genome, Human, Genome-Wide Association Study, Humans, Inheritance Patterns, Mental Disorders, Polymorphism, Single Nucleotide, Schizophrenia
Abstract

Most psychiatric disorders are moderately to highly heritable. The degree to which genetic variation is unique to individual disorders or shared across disorders is unclear. To examine shared genetic etiology, we use genome-wide genotype data from the Psychiatric Genomics Consortium (PGC) for cases and controls in schizophrenia, bipolar disorder, major depressive disorder, autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD). We apply univariate and bivariate methods for the estimation of genetic variation within and covariation between disorders. SNPs explained 17-29% of the variance in liability. The genetic correlation calculated using common SNPs was high between schizophrenia and bipolar disorder (0.68 ± 0.04 s.e.), moderate between schizophrenia and major depressive disorder (0.43 ± 0.06 s.e.), bipolar disorder and major depressive disorder (0.47 ± 0.06 s.e.), and ADHD and major depressive disorder (0.32 ± 0.07 s.e.), low between schizophrenia and ASD (0.16 ± 0.06 s.e.) and non-significant for other pairs of disorders as well as between psychiatric disorders and the negative control of Crohns disease. This empirical evidence of shared genetic etiology for psychiatric disorders can inform nosology and encourages the investigation of common pathophysiologies for related disorders.

Published
2013

9. Doing science : professional development and the experiences of teachers and pupils in primary classrooms

Author

Fraser, Christine Ann

Subjects
370.711, Teachers, Science
Abstract

This study is an exploration of the impact of teachers’ professional development on teachers’ and pupils’ experiences of science in primary schools.  It arose from the need to examine the primary science classroom as the context for both teachers’ and pupils’ learning to establish what those experiences were.  Qualitative data was collected from six primary school teachers using video-stimulated reflective dialogue and from four pupils in each class during group interviews.  Quantitative data, from six teachers and 118 pupil questionnaires, complemented qualitative data.  An activity theory perspective provided a framework for organising and interpreting the findings.  Findings showed primary teachers’ science-related learning was not usually undertaken in a way which provided, supported and validated positive experiences.  Hence, teachers’ confidence and ability to see themselves as teachers of primary science remained under-developed.  Therefore, despite theoretical views which espoused social constructivist, pupil-centred investigative approaches, in practice teachers tended to adopt teacher directed strategies focusing on control of the learning environment rather than pupils’ learning.  This restricted opportunities for teachers to learn from pupils, decreased pupils autonomy and limited pupils’ learning to the domains emphasised by the teacher.  Consequently, some pupils, some teachers, saw science as a difficult subject demanding memorisation of a large body of fragmented knowledge that had little relevance to everyday life and even less scope for creativity. The study concluded that current structures and practices, which do not support adequately the development of teachers’ science-related learning, need to change.  Such changes should enable teachers to understand the implication of contextual and social factors for the strategies they adopt and, hence, for pupils’ learning.

Published
2010

10. Toward Shared Decision-Making in Degenerative Cervical Myelopathy: Protocol for a Mixed Methods Study (Preprint)

Author

Sangeorzan, Irina, primary, Antonacci, Grazia, additional, Martin, Anne, additional, Grodzinski, Ben, additional, Zipser, Carl M, additional, Murphy, Rory K J, additional, Andriopoulou, Panoraia, additional, Cook, Chad E, additional, Anderson, David B, additional, Guest, James, additional, Furlan, Julio C, additional, Kotter, Mark R N, additional, Boerger, Timothy F, additional, Sadler, Iwan, additional, Roberts, Elizabeth A, additional, Wood, Helen, additional, Fraser, Christine, additional, Fehlings, Michael G, additional, Kumar, Vishal, additional, Jung, Josephine, additional, Milligan, James, additional, Nouri, Aria, additional, Martin, Allan R, additional, Blizzard, Tammy, additional, Vialle, Luiz Roberto, additional, Tetreault, Lindsay, additional, Kalsi-Ryan, Sukhvinder, additional, MacDowall, Anna, additional, Martin-Moore, Esther, additional, Burwood, Martin, additional, Wood, Lianne, additional, Lalkhen, Abdul, additional, Ito, Manabu, additional, Wilson, Nicky, additional, Treanor, Caroline, additional, Dugan, Sheila, additional, and Davies, Benjamin M, additional

Published
2023
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11. Toward Shared Decision-Making in Degenerative Cervical Myelopathy : Protocol for a Mixed Methods Study

Author

Sangeorzan, Irina, Antonacci, Grazia, Martin, Anne, Grodzinski, Ben, Zipser, Carl M., Murphy, Rory K. J., Andriopoulou, Panoraia, Cook, Chad E., Anderson, David B., Guest, James, Furlan, Julio C., Kotter, Mark R. N., Boerger, Timothy F., Sadler, Iwan, Roberts, Elizabeth A., Wood, Helen, Fraser, Christine, Fehlings, Michael G., Kumar, Vishal, Jung, Josephine, Milligan, James, Nouri, Aria, Martin, Allan R., Blizzard, Tammy, Vialle, Luiz Roberto, Tetreault, Lindsay, Kalsi-Ryan, Sukhvinder, MacDowall, Anna, Martin-Moore, Esther, Burwood, Martin, Wood, Lianne, Lalkhen, Abdul, Ito, Manabu, Wilson, Nicky, Treanor, Caroline, Dugan, Sheila, Davies, Benjamin M., Sangeorzan, Irina, Antonacci, Grazia, Martin, Anne, Grodzinski, Ben, Zipser, Carl M., Murphy, Rory K. J., Andriopoulou, Panoraia, Cook, Chad E., Anderson, David B., Guest, James, Furlan, Julio C., Kotter, Mark R. N., Boerger, Timothy F., Sadler, Iwan, Roberts, Elizabeth A., Wood, Helen, Fraser, Christine, Fehlings, Michael G., Kumar, Vishal, Jung, Josephine, Milligan, James, Nouri, Aria, Martin, Allan R., Blizzard, Tammy, Vialle, Luiz Roberto, Tetreault, Lindsay, Kalsi-Ryan, Sukhvinder, MacDowall, Anna, Martin-Moore, Esther, Burwood, Martin, Wood, Lianne, Lalkhen, Abdul, Ito, Manabu, Wilson, Nicky, Treanor, Caroline, Dugan, Sheila, and Davies, Benjamin M.

Abstract

Background: Health care decisions are a critical determinant in the evolution of chronic illness. In shared decision-making (SDM), patients and clinicians work collaboratively to reach evidence-based health decisions that align with individual circumstances, values, and preferences. This personalized approach to clinical care likely has substantial benefits in the oversight of degenerative cervical myelopathy (DCM), a type of nontraumatic spinal cord injury. Its chronicity, heterogeneous clinical presentation, complex management, and variable disease course engenders an imperative for a patient-centric approach that accounts for each patient's unique needs and priorities. Inadequate patient knowledge about the condition and an incomplete understanding of the critical decision points that arise during the course of care currently hinder the fruitful participation of health care providers and patients in SDM. This study protocol presents the rationale for deploying SDM for DCM and delineates the groundwork required to achieve this. Objective: The study's primary outcome is the development of a comprehensive checklist to be implemented upon diagnosis that provides patients with essential information necessary to support their informed decision-making. This is known as a core information set (CIS). The secondary outcome is the creation of a detailed process map that provides a diagrammatic representation of the global care workflows and cognitive processes involved in DCM care. Characterizing the critical decision points along a patient's journey will allow for an effective exploration of SDM tools for routine clinical practice to enhance patient-centered care and improve clinical outcomes. Methods: Both CISs and process maps are coproduced iteratively through a collaborative process involving the input and consensus of key stakeholders. This will be facilitated by Myelopathy.org, a global DCM charity, through its Research Objectives and Common Data Elements for Degener

Published
2023
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12. Toward Shared Decision-Making in Degenerative Cervical Myelopathy: Protocol for a Mixed Methods Study

Author

Sangeorzan, Irina; https://orcid.org/0000-0002-2170-2218, Antonacci, Grazia; https://orcid.org/0000-0001-7742-8003, Martin, Anne; https://orcid.org/0000-0003-4225-6998, Grodzinski, Ben; https://orcid.org/0000-0001-8839-4718, Zipser, Carl M; https://orcid.org/0000-0002-4396-4796, Murphy, Rory K J; https://orcid.org/0000-0001-9634-1253, Andriopoulou, Panoraia; https://orcid.org/0000-0002-5745-6741, Cook, Chad E; https://orcid.org/0000-0001-8622-8361, Anderson, David B; https://orcid.org/0000-0001-7104-122X, Guest, James; https://orcid.org/0000-0003-0931-0286, Furlan, Julio C; https://orcid.org/0000-0002-2038-0018, Kotter, Mark R N; https://orcid.org/0000-0001-5145-7199, Boerger, Timothy F; https://orcid.org/0000-0003-1587-3704, Sadler, Iwan; https://orcid.org/0000-0002-8696-1122, Roberts, Elizabeth A; https://orcid.org/0000-0003-2738-4203, Wood, Helen; https://orcid.org/0000-0001-6976-4736, Fraser, Christine; https://orcid.org/0000-0001-9519-6170, Fehlings, Michael G; https://orcid.org/0000-0002-5722-6364, Kumar, Vishal; https://orcid.org/0000-0002-6707-4560, Jung, Josephine; https://orcid.org/0000-0002-0056-440X, Milligan, James; https://orcid.org/0000-0003-3387-1614, Nouri, Aria; https://orcid.org/0000-0002-4965-3059, Martin, Allan R; https://orcid.org/0000-0002-9495-5654, Blizzard, Tammy; https://orcid.org/0000-0002-0335-9612, Vialle, Luiz Roberto; https://orcid.org/0000-0002-0638-4311, Tetreault, Lindsay; https://orcid.org/0000-0001-8435-4292, Kalsi-Ryan, Sukhvinder; https://orcid.org/0000-0003-2332-5986, MacDowall, Anna; https://orcid.org/0000-0002-9231-7608, Martin-Moore, Esther; https://orcid.org/0000-0002-6151-3040, Burwood, Martin; https://orcid.org/0000-0003-0339-1011, et al, Sangeorzan, Irina; https://orcid.org/0000-0002-2170-2218, Antonacci, Grazia; https://orcid.org/0000-0001-7742-8003, Martin, Anne; https://orcid.org/0000-0003-4225-6998, Grodzinski, Ben; https://orcid.org/0000-0001-8839-4718, Zipser, Carl M; https://orcid.org/0000-0002-4396-4796, Murphy, Rory K J; https://orcid.org/0000-0001-9634-1253, Andriopoulou, Panoraia; https://orcid.org/0000-0002-5745-6741, Cook, Chad E; https://orcid.org/0000-0001-8622-8361, Anderson, David B; https://orcid.org/0000-0001-7104-122X, Guest, James; https://orcid.org/0000-0003-0931-0286, Furlan, Julio C; https://orcid.org/0000-0002-2038-0018, Kotter, Mark R N; https://orcid.org/0000-0001-5145-7199, Boerger, Timothy F; https://orcid.org/0000-0003-1587-3704, Sadler, Iwan; https://orcid.org/0000-0002-8696-1122, Roberts, Elizabeth A; https://orcid.org/0000-0003-2738-4203, Wood, Helen; https://orcid.org/0000-0001-6976-4736, Fraser, Christine; https://orcid.org/0000-0001-9519-6170, Fehlings, Michael G; https://orcid.org/0000-0002-5722-6364, Kumar, Vishal; https://orcid.org/0000-0002-6707-4560, Jung, Josephine; https://orcid.org/0000-0002-0056-440X, Milligan, James; https://orcid.org/0000-0003-3387-1614, Nouri, Aria; https://orcid.org/0000-0002-4965-3059, Martin, Allan R; https://orcid.org/0000-0002-9495-5654, Blizzard, Tammy; https://orcid.org/0000-0002-0335-9612, Vialle, Luiz Roberto; https://orcid.org/0000-0002-0638-4311, Tetreault, Lindsay; https://orcid.org/0000-0001-8435-4292, Kalsi-Ryan, Sukhvinder; https://orcid.org/0000-0003-2332-5986, MacDowall, Anna; https://orcid.org/0000-0002-9231-7608, Martin-Moore, Esther; https://orcid.org/0000-0002-6151-3040, Burwood, Martin; https://orcid.org/0000-0003-0339-1011, and et al

Abstract

BACKGROUND Health care decisions are a critical determinant in the evolution of chronic illness. In shared decision-making (SDM), patients and clinicians work collaboratively to reach evidence-based health decisions that align with individual circumstances, values, and preferences. This personalized approach to clinical care likely has substantial benefits in the oversight of degenerative cervical myelopathy (DCM), a type of nontraumatic spinal cord injury. Its chronicity, heterogeneous clinical presentation, complex management, and variable disease course engenders an imperative for a patient-centric approach that accounts for each patient's unique needs and priorities. Inadequate patient knowledge about the condition and an incomplete understanding of the critical decision points that arise during the course of care currently hinder the fruitful participation of health care providers and patients in SDM. This study protocol presents the rationale for deploying SDM for DCM and delineates the groundwork required to achieve this. OBJECTIVE The study's primary outcome is the development of a comprehensive checklist to be implemented upon diagnosis that provides patients with essential information necessary to support their informed decision-making. This is known as a core information set (CIS). The secondary outcome is the creation of a detailed process map that provides a diagrammatic representation of the global care workflows and cognitive processes involved in DCM care. Characterizing the critical decision points along a patient's journey will allow for an effective exploration of SDM tools for routine clinical practice to enhance patient-centered care and improve clinical outcomes. METHODS Both CISs and process maps are coproduced iteratively through a collaborative process involving the input and consensus of key stakeholders. This will be facilitated by Myelopathy.org, a global DCM charity, through its Research Objectives and Common Data Elements for Degenerati

Published
2023

15. From Science as 'Content' to Science as 'Interpretive Key': Experiences and Reflections from a Science Course in Teacher Education

Author

Colucci-Gray, Laura and Fraser, Christine

Abstract

Despite science's central role in European culture, public perception of, and participation with, science is characterised by contradictions and conflicting agenda. School curriculum reform, for example by Scottish Government, promotes "science for citizenship", yet teachers' understandings of the nature of science and its relationship with society are often underdeveloped. This article reports on the experiences of a group of first-year students enrolled in the course "socio-cultural perspectives in science learning" within a primary teacher education programme. Drawing on sociocultural theory, attention was given to language as a system for constructing symbolic realities. Through participation in activities, which explored science knowledge production and communication, students were encouraged to reflect on the nature of science and the dynamic relationship between content, methods and value-frameworks. Findings cluster around interconnected themes: students' views of knowledge, language genres across communities and knowledge-power negotiations. The course attempted to move from a space for knowledge consumption to an intermediary space between science and society for students to inhabit in the dual roles of citizens and co-constructors of knowledge. In this transition, linguistic genres pointed to the complexity of interactions between curricular materials offered by the course and newly established social networks. The article argues for further consideration of linguistic practices in science education as a means for disclosing interpretations and cultural framings and a necessary step in equipping teachers to understand "science for citizenship" issues. (Contains 1 table and 2 figures.)

Published
2012
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16. Continuing Professional Development and Learning in Primary Science Classrooms

Author

Fraser, Christine A.

Abstract

This article explores the effects of continuing professional development (CPD) on teachers' and pupils' experiences of learning and teaching science in primary classrooms. During 2006-2007, quantitative and qualitative data were elicited from two primary teachers in Scotland using questionnaires, semi-structured interviews and video-stimulated reflective dialogues (VSRD) associated with specific learning experiences. During the same period, quantitative data were elicited from 40 pupils using questionnaires and qualitative data obtained from dialogues with eight pupils in two focus groups. Two teacher interviews, four teacher-researcher dialogues and two pupil focus group interviews were audio-recorded, transcribed and coded inductively. Cultural historical activity theory (CHAT) was used as a framework for analysis of the coded data. The data indicated differences in participating teachers' views of the purposes of CPD which were reflected in their ideal and real views of effective science teaching. The combination of VSRD and CHAT made explicit the links between, and compensatory use of, formal and informal CPD and subject and pedagogical knowledge in relation to science. This enabled exploration of the influences of these factors on teachers' negotiation of barriers and constraints to teaching science through investigation and the effects on pupils' learning. As a result, reconciliation of ideal and real views of effective science teaching, identification of potential constraints and development of strategies for overcoming constraints in context are suggested as useful starting points for CPD which, it is argued, should be regarded as a career-long continuum. (Contains 9 tables and 3 notes.)

Published
2010
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17. Key Informants' Perspectives on Teacher Learning in Scotland

Author

Kennedy, Aileen, Christie, Donald, Fraser, Christine, Reid, Lesley, McKinney, Stephen, Welsh, Mary, Wilson, Alastair, and Griffiths, Morwenna

Abstract

This article outlines the policy context for teachers' learning and continuing professional development in Scotland and considers this in relation to the perspectives of key informants gained through interview. The analysis draws on a triple-lens conceptual framework and points to some interesting contradictions between the policy text and the expressed aspirations of the interviewees. Current policy and the associated structural arrangements are viewed as broadly positive, but interviewees express concerns that an unintended emphasis on contractual arrangements might inhibit the more transformative elements of professional learning.

Published
2008
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18. Contested Aspects of Becoming a Teacher: Teacher Learning and the Role of Subject Knowledge

Author

Colucci-Gray, Laura and Fraser, Christine

Abstract

Teaching is acknowledged to be complex, multifaceted and dynamic. Curriculum revisions in Scotland, and elsewhere, call for teachers who are adaptable and capable of change. Yet the skills and attributes traditionally valued and acquired by teachers during their education do not necessarily equip them to cope with the shifting landscape of educational change. This article draws on a collaborative review of literature relating to teacher education, undertaken for the Scottish Teachers for a New Era project. It examines the nature of knowledge for teaching generally and in relation to science education in particular to discuss contested aspects and to develop a conceptual framework for future research and development in this area. The main argument for this study is that a reformulation of teacher education is required. This involves changing the way teachers are educated within an accompanying shift in epistemology and a move to interdisciplinarity. It calls for a more egalitarian way of learning as a means to facilitate change within schools for the creation of a more equal and just society.

Published
2008
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19. Teachers' Continuing Professional Development: Contested Concepts, Understandings and Models

Author

Fraser, Christine, Kennedy, Aileen, and Reid, Lesley

Abstract

Teachers' continuing professional development (CPD) is being given increasing importance in countries throughout the world. In Scotland, the changing professional and political context has resulted in unprecedented investment in CPD. However, analysis and evaluation of CPD policies, practice and impact is complex. In seeking to understand some of the complexities, this article proposes a triple-lens framework, drawing on three different accounts of teacher learning. The framework is then used to analyse three specific examples of CPD initiatives. Conclusions point to the need to consider a much wider conception of teacher learning in which socio-cultural aspects are given due attention. (Contains 1 figure, 1 table, and 1 note.)

Published
2007
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21. Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders

Author

Blokland, Gabriëlla A.M., primary, Grove, Jakob, additional, Chen, Chia-Yen, additional, Cotsapas, Chris, additional, Tobet, Stuart, additional, Handa, Robert, additional, St Clair, David, additional, Lencz, Todd, additional, Mowry, Bryan J., additional, Periyasamy, Sathish, additional, Cairns, Murray J., additional, Tooney, Paul A., additional, Wu, Jing Qin, additional, Kelly, Brian, additional, Kirov, George, additional, Sullivan, Patrick F., additional, Corvin, Aiden, additional, Riley, Brien P., additional, Esko, Tõnu, additional, Milani, Lili, additional, Jönsson, Erik G., additional, Palotie, Aarno, additional, Ehrenreich, Hannelore, additional, Begemann, Martin, additional, Steixner-Kumar, Agnes, additional, Sham, Pak C., additional, Iwata, Nakao, additional, Weinberger, Daniel R., additional, Gejman, Pablo V., additional, Sanders, Alan R., additional, Buxbaum, Joseph D., additional, Rujescu, Dan, additional, Giegling, Ina, additional, Konte, Bettina, additional, Hartmann, Annette M., additional, Bramon, Elvira, additional, Murray, Robin M., additional, Pato, Michele T., additional, Lee, Jimmy, additional, Melle, Ingrid, additional, Molden, Espen, additional, Ophoff, Roel A., additional, McQuillin, Andrew, additional, Bass, Nicholas J., additional, Adolfsson, Rolf, additional, Malhotra, Anil K., additional, Martin, Nicholas G., additional, Fullerton, Janice M., additional, Mitchell, Philip B., additional, Schofield, Peter R., additional, Forstner, Andreas J., additional, Degenhardt, Franziska, additional, Schaupp, Sabrina, additional, Comes, Ashley L., additional, Kogevinas, Manolis, additional, Guzman-Parra, José, additional, Reif, Andreas, additional, Streit, Fabian, additional, Sirignano, Lea, additional, Cichon, Sven, additional, Grigoroiu-Serbanescu, Maria, additional, Hauser, Joanna, additional, Lissowska, Jolanta, additional, Mayoral, Fermin, additional, Müller-Myhsok, Bertram, additional, Świątkowska, Beata, additional, Schulze, Thomas G., additional, Nöthen, Markus M., additional, Rietschel, Marcella, additional, Kelsoe, John, additional, Leboyer, Marion, additional, Jamain, Stéphane, additional, Etain, Bruno, additional, Bellivier, Frank, additional, Vincent, John B., additional, Alda, Martin, additional, O’Donovan, Claire, additional, Cervantes, Pablo, additional, Biernacka, Joanna M., additional, Frye, Mark, additional, McElroy, Susan L., additional, Scott, Laura J., additional, Stahl, Eli A., additional, Landén, Mikael, additional, Hamshere, Marian L., additional, Smeland, Olav B., additional, Djurovic, Srdjan, additional, Vaaler, Arne E., additional, Andreassen, Ole A., additional, Baune, Bernhard T., additional, Air, Tracy, additional, Preisig, Martin, additional, Uher, Rudolf, additional, Levinson, Douglas F., additional, Weissman, Myrna M., additional, Potash, James B., additional, Shi, Jianxin, additional, Knowles, James A., additional, Perlis, Roy H., additional, Lucae, Susanne, additional, Boomsma, Dorret I., additional, Penninx, Brenda W.J.H., additional, Hottenga, Jouke-Jan, additional, de Geus, Eco J.C., additional, Willemsen, Gonneke, additional, Milaneschi, Yuri, additional, Tiemeier, Henning, additional, Grabe, Hans J., additional, Teumer, Alexander, additional, Van der Auwera, Sandra, additional, Völker, Uwe, additional, Hamilton, Steven P., additional, Magnusson, Patrik K.E., additional, Viktorin, Alexander, additional, Mehta, Divya, additional, Mullins, Niamh, additional, Adams, Mark J., additional, Breen, Gerome, additional, McIntosh, Andrew M., additional, Lewis, Cathryn M., additional, Hougaard, David M., additional, Nordentoft, Merete, additional, Mors, Ole, additional, Mortensen, Preben B., additional, Werge, Thomas, additional, Als, Thomas D., additional, Børglum, Anders D., additional, Petryshen, Tracey L., additional, Smoller, Jordan W., additional, Goldstein, Jill M., additional, Ripke, Stephan, additional, Neale, Benjamin M., additional, Walters, James T.R., additional, Farh, Kai-How, additional, Holmans, Peter A., additional, Lee, Phil, additional, Bulik-Sullivan, Brendan, additional, Collier, David A., additional, Huang, Hailiang, additional, Pers, Tune H., additional, Agartz, Ingrid, additional, Agerbo, Esben, additional, Albus, Margot, additional, Alexander, Madeline, additional, Amin, Farooq, additional, Bacanu, Silviu A., additional, Belliveau, Richard A., additional, Bene, Judit, additional, Bergen, Sarah E., additional, Bevilacqua, Elizabeth, additional, Bigdeli, Tim B., additional, Black, Donald W., additional, Bruggeman, Richard, additional, Buccola, Nancy G., additional, Buckner, Randy L., additional, Byerley, William, additional, Cahn, Wiepke, additional, Cai, Guiqing, additional, Campion, Dominique, additional, Cantor, Rita M., additional, Carr, Vaughan J., additional, Carrera, Noa, additional, Catts, Stanley V., additional, Chambert, Kimberly D., additional, Chan, Raymond C.K., additional, Chen, Ronald Y.L., additional, Chen, Eric Y.H., additional, Cheng, Wei, additional, Cheung, Eric F.C., additional, Chong, Siow Ann, additional, Cloninger, C. Robert, additional, Cohen, David, additional, Cohen, Nadine, additional, Cormican, Paul, additional, Craddock, Nick, additional, Crowley, James J., additional, Curtis, David, additional, Davidson, Michael, additional, Davis, Kenneth L., additional, Del Favero, Jurgen, additional, Demontis, Ditte, additional, Dikeos, Dimitris, additional, Dinan, Timothy, additional, Donohoe, Gary, additional, Drapeau, Elodie, additional, Duan, Jubao, additional, Dudbridge, Frank, additional, Durmishi, Naser, additional, Eichhammer, Peter, additional, Eriksson, Johan, additional, Escott-Price, Valentina, additional, Essioux, Laurent, additional, Fanous, Ayman H., additional, Farrell, Martilias S., additional, Frank, Josef, additional, Franke, Lude, additional, Freedman, Robert, additional, Freimer, Nelson B., additional, Friedl, Marion, additional, Friedman, Joseph I., additional, Fromer, Menachem, additional, Genovese, Giulio, additional, Georgieva, Lyudmila, additional, Giusti-Rodríguez, Paola, additional, Godard, Stephanie, additional, Goldstein, Jacqueline I., additional, Golimbet, Vera, additional, Gopal, Srihari, additional, Gratten, Jacob, additional, de Haan, Lieuwe, additional, Hammer, Christian, additional, Hansen, Mark, additional, Hansen, Thomas, additional, Haroutunian, Vahram, additional, Henskens, Frans A., additional, Herms, Stefan, additional, Hirschhorn, Joel N., additional, Hoffmann, Per, additional, Hofman, Andrea, additional, Hollegaard, Mads V., additional, Ikeda, Masashi, additional, Joa, Inge, additional, Julià, Antonio, additional, Kahn, René S., additional, Kalaydjieva, Luba, additional, Karachanak-Yankova, Sena, additional, Karjalainen, Juha, additional, Kavanagh, David, additional, Keller, Matthew C., additional, Kennedy, James L., additional, Khrunin, Andrey, additional, Kim, Yunjung, additional, Klovins, Janis, additional, Kucinskas, Vaidutis, additional, Kucinskiene, Zita Ausrele, additional, Kuzelova-Ptackova, Hana, additional, Kähler, Anna K., additional, Laurent, Claudine, additional, Lee Chee Keong, Jimmy, additional, Lee, S. Hong, additional, Legge, Sophie E., additional, Lerer, Bernard, additional, Li, Miaoxin, additional, Li, Tao, additional, Liang, Kung-Yee, additional, Lieberman, Jeffrey, additional, Limborska, Svetlana, additional, Loughland, Carmel M., additional, Lubinski, Jan, additional, Lönnqvist, Jouko, additional, Macek, Milan, additional, Maher, Brion S., additional, Maier, Wolfgang, additional, Mallet, Jacques, additional, Marsal, Sara, additional, Mattheisen, Manuel, additional, Mattingsdal, Morten, additional, McCarley, Robert W., additional, McDonald, Colm, additional, Meier, Sandra, additional, Meijer, Carin J., additional, Melegh, Bela, additional, Mesholam-Gately, Raquelle I., additional, Metspalu, Andres, additional, Michie, Patricia T., additional, Milanova, Vihra, additional, Mokrab, Younes, additional, Morris, Derek W., additional, Murphy, Kieran C., additional, Myin-Germeys, Inez, additional, Nelis, Mari, additional, Nenadic, Igor, additional, Nertney, Deborah A., additional, Nestadt, Gerald, additional, Nicodemus, Kristin K., additional, Nikitina-Zake, Liene, additional, Nisenbaum, Laura, additional, Nordin, Annelie, additional, O’Callaghan, Eadbhard, additional, O’Dushlaine, Colm, additional, O’Neill, F. Anthony, additional, Oh, Sang-Yun, additional, Olincy, Ann, additional, Olsen, Line, additional, Van Os, Jim, additional, Pantelis, Christos, additional, Papadimitriou, George N., additional, Papiol, Sergi, additional, Parkhomenko, Elena, additional, Paunio, Tiina, additional, Pejovic-Milovancevic, Milica, additional, Perkins, Diana O., additional, Pietiläinen, Olli, additional, Pimm, Jonathan, additional, Pocklington, Andrew J., additional, Powell, John, additional, Price, Alkes, additional, Pulver, Ann E., additional, Purcell, Shaun M., additional, Quested, Digby, additional, Rasmussen, Henrik B., additional, Reichenberg, Abraham, additional, Reimers, Mark A., additional, Richards, Alexander L., additional, Roffman, Joshua L., additional, Roussos, Panos, additional, Ruderfer, Douglas M., additional, Salomaa, Veikko, additional, Schall, Ulrich, additional, Schubert, Christian R., additional, Schwab, Sibylle G., additional, Scolnick, Edward M., additional, Scott, Rodney J., additional, Seidman, Larry J., additional, Sigurdsson, Engilbert, additional, Silagadze, Teimuraz, additional, Silverman, Jeremy M., additional, Sim, Kang, additional, Slominsky, Petr, additional, So, Hon-Cheong, additional, Spencer, Chris C.A., additional, Stefansson, Hreinn, additional, Steinberg, Stacy, additional, Stogmann, Elisabeth, additional, Straub, Richard E., additional, Strengman, Eric, additional, Strohmaier, Jana, additional, Stroup, T. Scott, additional, Subramaniam, Mythily, additional, Suvisaari, Jaana, additional, Svrakic, Dragan M., additional, Szatkiewicz, Jin P., additional, Söderman, Erik, additional, Thirumalai, Srinivas, additional, Toncheva, Draga, additional, Tosato, Sarah, additional, Veijola, Juha, additional, Waddington, John, additional, Walsh, Dermot, additional, Wang, Dai, additional, Wang, Qiang, additional, Webb, Bradley T., additional, Weiser, Mark, additional, Wildenauer, Dieter B., additional, Williams, Nigel M., additional, Williams, Stephanie, additional, Witt, Stephanie H., additional, Wolen, Aaron R., additional, Wong, Emily H.M., additional, Wormley, Brandon K., additional, Xi, Hualin Simon, additional, Zai, Clement C., additional, Zheng, Xuebin, additional, Zimprich, Fritz, additional, Wray, Naomi R., additional, Stefansson, Kari, additional, Visscher, Peter M., additional, Blackwood, Douglas H.R., additional, Darvasi, Ariel, additional, Domenici, Enrico, additional, Gill, Michael, additional, Gurling, Hugh, additional, Hultman, Christina M., additional, Jablensky, Assen V., additional, Kendler, Kenneth S., additional, Knight, Jo, additional, Li, Qingqin S., additional, Liu, Jianjun, additional, McCarroll, Steven A., additional, Moran, Jennifer L., additional, Owen, Michael J., additional, Pato, Carlos N., additional, Posthuma, Danielle, additional, Sklar, Pamela, additional, Wendland, Jens R., additional, Daly, Mark J., additional, O’Donovan, Michael C., additional, Donnelly, Peter, additional, Barroso, Ines, additional, Blackwell, Jenefer M., additional, Brown, Matthew A., additional, Casas, Juan P., additional, Deloukas, Panos, additional, Duncanson, Audrey, additional, Jankowski, Janusz, additional, Markus, Hugh S., additional, Mathew, Christopher G., additional, Palmer, Colin N.A., additional, Plomin, Robert, additional, Rautanen, Anna, additional, Sawcer, Stephen J., additional, Trembath, Richard C., additional, Viswanathan, Ananth C., additional, Wood, Nicholas W., additional, Band, Gavin, additional, Bellenguez, Céline, additional, Freeman, Colin, additional, Giannoulatou, Eleni, additional, Hellenthal, Garrett, additional, Pearson, Richard, additional, Pirinen, Matti, additional, Strange, Amy, additional, Su, Zhan, additional, Vukcevic, Damjan, additional, Langford, Cordelia, additional, Blackburn, Hannah, additional, Bumpstead, Suzannah J., additional, Dronov, Serge, additional, Edkins, Sarah, additional, Gillman, Matthew, additional, Gray, Emma, additional, Gwilliam, Rhian, additional, Hammond, Naomi, additional, Hunt, Sarah E., additional, Jayakumar, Alagurevathi, additional, Liddle, Jennifer, additional, McCann, Owen T., additional, Potter, Simon C., additional, Ravindrarajah, Radhi, additional, Ricketts, Michelle, additional, Tashakkori-Ghanbaria, Avazeh, additional, Waller, Matthew, additional, Weston, Paul, additional, Whittaker, Pamela, additional, Widaa, Sara, additional, McCarthy, Mark I., additional, Arranz, Maria J., additional, Bakker, Steven, additional, Bender, Stephan, additional, Crespo-Facorro, Benedicto, additional, Hall, Jeremy, additional, Iyegbe, Conrad, additional, Lawrie, Stephen, additional, Lin, Kuang, additional, Linszen, Don H., additional, Mata, Ignacio, additional, Walshe, Muriel, additional, Weisbrod, Matthias, additional, Wiersma, Durk, additional, Trubetskoy, Vassily, additional, Wang, Yunpeng, additional, Coleman, Jonathan R.I., additional, Gaspar, Héléna A., additional, de Leeuw, Christiaan A., additional, Whitehead Pavlides, Jennifer M., additional, Trzaskowski, Maciej, additional, Byrne, Enda M., additional, Abbott, Liam, additional, Akil, Huda, additional, Albani, Diego, additional, Alliey-Rodriguez, Ney, additional, Anjorin, Adebayo, additional, Antilla, Verneri, additional, Awasthi, Swapnil, additional, Badner, Judith A., additional, Bækvad-Hansen, Marie, additional, Barchas, Jack D., additional, Bass, Nicholas, additional, Bauer, Michael, additional, Belliveau, Richard, additional, Pedersen, Carsten Bøcker, additional, Bøen, Erlend, additional, Boks, Marco P., additional, Boocock, James, additional, Budde, Monika, additional, Bunney, William, additional, Burmeister, Margit, additional, Bybjerg-Grauholm, Jonas, additional, Casas, Miquel, additional, Cerrato, Felecia, additional, Chambert, Kimberly, additional, Charney, Alexander W., additional, Chen, Danfeng, additional, Churchhouse, Claire, additional, Clarke, Toni-Kim, additional, Coryell, William, additional, Craig, David W., additional, Cruceanu, Cristiana, additional, Czerski, Piotr M., additional, Dale, Anders M., additional, de Jong, Simone, additional, Del-Favero, Jurgen, additional, DePaulo, J. Raymond, additional, Dobbyn, Amanda L., additional, Dumont, Ashley, additional, Elvsåshagen, Torbjørn, additional, Fan, Chun Chieh, additional, Fischer, Sascha B., additional, Flickinger, Matthew, additional, Foroud, Tatiana M., additional, Forty, Liz, additional, Fraser, Christine, additional, Gade, Katrin, additional, Gage, Diane, additional, Garnham, Julie, additional, Giambartolomei, Claudia, additional, Pedersen, Marianne Giørtz, additional, Goldstein, Jaqueline, additional, Gordon, Scott D., additional, Gordon-Smith, Katherine, additional, Green, Elaine K., additional, Green, Melissa J., additional, Greenwood, Tiffany A., additional, Guan, Weihua, additional, Hautzinger, Martin, additional, Heilbronner, Urs, additional, Hipolito, Maria, additional, Holland, Dominic, additional, Huckins, Laura, additional, Johnson, Jessica S., additional, Kandaswamy, Radhika, additional, Karlsson, Robert, additional, Kittel-Schneider, Sarah, additional, Koller, Anna C., additional, Kupka, Ralph, additional, Lavebratt, Catharina, additional, Lawrence, Jacob, additional, Lawson, William B., additional, Leber, Markus, additional, Lee, Phil H., additional, Levy, Shawn E., additional, Li, Jun Z., additional, Liu, Chunyu, additional, Maaser, Anna, additional, MacIntyre, Donald J., additional, Mahon, Pamela B., additional, Martinsson, Lina, additional, McCarroll, Steve, additional, McGuffin, Peter, additional, McInnis, Melvin G., additional, McKay, James D., additional, Medeiros, Helena, additional, Medland, Sarah E., additional, Meng, Fan, additional, Montgomery, Grant W., additional, Mühleisen, Thomas W., additional, Nguyen, Hoang, additional, Nievergelt, Caroline M., additional, Adolfsson, Annelie Nordin, additional, Nwulia, Evaristus A., additional, O'Donovan, Claire, additional, Olde Loohuis, Loes M., additional, Ori, Anil P.S., additional, Oruc, Lilijana, additional, Ösby, Urban, additional, Perry, Amy, additional, Pfennig, Andrea, additional, Regeer, Eline J., additional, Reinbold, Céline S., additional, Rice, John P., additional, Rivas, Fabio, additional, Rivera, Margarita, additional, Ryu, Euijung, additional, Sánchez-Mora, Cristina, additional, Schatzberg, Alan F., additional, Scheftner, William A., additional, Schork, Nicholas J., additional, Weickert, Cynthia Shannon, additional, Shehktman, Tatyana, additional, Shilling, Paul D., additional, Slaney, Claire, additional, Sobell, Janet L., additional, Hansen, Christine Søholm, additional, Spijker, Anne T., additional, Steffens, Michael, additional, Strauss, John S., additional, Szelinger, Szabolcs, additional, Thompson, Robert C., additional, Thorgeirsson, Thorgeir E., additional, Treutlein, Jens, additional, Vedder, Helmut, additional, Wang, Weiqing, additional, Watson, Stanley J., additional, Weickert, Thomas W., additional, Xi, Simon, additional, Xu, Wei, additional, Young, Allan H., additional, Zandi, Peter, additional, Zhang, Peng, additional, Zöllner, Sebastian, additional, Abdellaoui, Abdel, additional, Air, Tracy M., additional, Andlauer, Till F.M., additional, Bacanu, Silviu-Alin, additional, Beekman, Aartjan T.F., additional, Binder, Elisabeth B., additional, Bryois, Julien, additional, Buttenschøn, Henriette N., additional, Cai, Na, additional, Castelao, Enrique, additional, Christensen, Jane Hvarregaard, additional, Colodro-Conde, Lucía, additional, Couvy-Duchesne, Baptiste, additional, Crawford, Gregory E., additional, Davies, Gail, additional, Deary, Ian J., additional, Derks, Eske M., additional, Direk, Nese, additional, Dolan, Conor V., additional, Dunn, Erin C., additional, Eley, Thalia C., additional, Hassan Kiadeh, Farnush Farhadi, additional, Finucane, Hilary K., additional, Foo, Jerome C., additional, Goes, Fernando S., additional, Hall, Lynsey S., additional, Hansen, Thomas F., additional, Hickie, Ian B., additional, Homuth, Georg, additional, Horn, Carsten, additional, Howard, David M., additional, Ising, Marcus, additional, Jansen, Rick, additional, Jones, Ian, additional, Jones, Lisa A., additional, Jorgenson, Eric, additional, Kohane, Isaac S., additional, Kraft, Julia, additional, Kretzschmar, Warren W., additional, Kutalik, Zoltán, additional, Li, Yihan, additional, Lind, Penelope A., additional, MacKinnon, Dean F., additional, Maier, Robert M., additional, Marchini, Jonathan, additional, Mbarek, Hamdi, additional, McGrath, Patrick, additional, Middeldorp, Christel M., additional, Mihailov, Evelin, additional, Mondimore, Francis M., additional, Mostafavi, Sara, additional, Nauck, Matthias, additional, Ng, Bernard, additional, Nivard, Michel G., additional, Nyholt, Dale R., additional, O'Reilly, Paul F., additional, Oskarsson, Hogni, additional, Painter, Jodie N., additional, Peterson, Roseann E., additional, Peyrot, Wouter J., additional, Pistis, Giorgio, additional, Quiroz, Jorge A., additional, Qvist, Per, additional, Mirza, Saira Saeed, additional, Schoevers, Robert, additional, Schulte, Eva C., additional, Shen, Ling, additional, Shyn, Stanley I., additional, Sinnamon, Grant C.B., additional, Smit, Johannes H., additional, Smith, Daniel J., additional, Tansey, Katherine E., additional, Teismann, Henning, additional, Thompson, Wesley, additional, Thomson, Pippa A., additional, Traylor, Matthew, additional, Uitterlinden, André G., additional, Umbricht, Daniel, additional, van Hemert, Albert M., additional, Weinsheimer, Shantel Marie, additional, Wellmann, Jürgen, additional, Wu, Yang, additional, Xi, Hualin S., additional, Yang, Jian, additional, Zhang, Futao, additional, Arolt, Volker, additional, Berger, Klaus, additional, Dannlowski, Udo, additional, Domschke, Katharina, additional, Hayward, Caroline, additional, Heath, Andrew C., additional, Kloiber, Stefan, additional, Lewis, Glyn, additional, Madden, Pamela AF., additional, Magnusson, Patrik K., additional, Mortensen, Preben Bo, additional, O'Donovan, Michael C., additional, Paciga, Sara A., additional, Pedersen, Nancy L., additional, Porteous, David J., additional, Schaefer, Catherine, additional, Völzke, Henry, additional, Blokland, Gabriëlla A.M., additional, Bortolato, Marco, additional, Bralten, Janita, additional, Bulik, Cynthia M., additional, Burton, Christie L., additional, Carey, Caitlin E., additional, Davis, Lea K., additional, Duncan, Laramie E., additional, Edenberg, Howard J., additional, Erdman, Lauren, additional, Faraone, Stephen V., additional, Goleva, Slavina B., additional, Guo, Wei, additional, Hübel, Christopher, additional, Huckins, Laura M., additional, Khramtsova, Ekaterina A., additional, Martin, Joanna, additional, Mathews, Carol A., additional, Robinson, Elise, additional, Stahl, Eli, additional, Stranger, Barbara E., additional, Traglia, Michela, additional, Walters, Raymond K., additional, Weiss, Lauren A., additional, Winham, Stacey J., additional, Yao, Yin, additional, Skajaa, Kristjar, additional, Nöthen, Markus, additional, Owen, Michael, additional, Yolken, Robert H., additional, Plath, Niels, additional, Mill, Jonathan, additional, and Geschwind, Daniel, additional

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2022
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25. Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders

Author

Andlauer, Till F M, Guzman-Parra, Jose, Orozco Diaz, Guillermo, Freimer, Nelson B, Frisén, Louise, Gade, Katrin, Gage, Diane, Garnham, Julie, Giambartolomei, Claudia, Pedersen, Marianne Giørtz, Goldstein, Jaqueline, Gordon, Scott D, Gordon-Smith, Katherine, de Diego-Otero, Yolanda, Green, Elaine K, Green, Melissa J, Greenwood, Tiffany A, Grove, Jakob, Guan, Weihua, Parra, José Guzman, Hamshere, Marian L, Hautzinger, Martin, Heilbronner, Urs, Herms, Stefan, Moreno-Küstner, Berta, Hipolito, Maria, Hoffmann, Per, Holland, Dominic, Huckins, Laura, Jamain, Stéphane, Johnson, Jessica S, Juréus, Anders, Kandaswamy, Radhika, Karlsson, Robert, Kennedy, James L, Auburger, Georg, Kittel-Schneider, Sarah, Knowles, James A, Kogevinas, Manolis, Koller, Anna C, Kupka, Ralph, Lavebratt, Catharina, Lawrence, Jacob, Lawson, William B, Leber, Markus, Lee, Phil H, Degenhardt, Franziska, Levy, Shawn E, Li, Jun Z, Liu, Chunyu, Lucae, Susanne, Maaser, Anna, MacIntyre, Donald J, Mahon, Pamela B, Maier, Wolfgang, Martinsson, Lina, McCarroll, Steve, Heilmann-Heimbach, Stefanie, McGuffin, Peter, McInnis, Melvin G, McKay, James D, Medeiros, Helena, Medland, Sarah E, Meng, Fan, Milani, Lili, Montgomery, Grant W, Morris, Derek W, Mühleisen, Thomas W, Mullins, Niamh, Nguyen, Hoang, Nievergelt, Caroline M, Adolfsson, Annelie Nordin, Nwulia, Evaristus A, O'Donovan, Claire, Loohuis, Loes M Olde, Ori, Anil P S, Oruc, Lilijana, Ösby, Urban, Perlis, Roy H, Perry, Amy, Pfennig, Andrea, Potash, James B, Purcell, Shaun M, Regeer, Eline J, Reif, Andreas, Reinbold, Céline S, Rice, John P, Richards, Alexander L, Frank, Josef, Rivas, Fabio, Rivera, Margarita, Roussos, Panos, Ruderfer, Douglas M, Ryu, Euijung, Sánchez-Mora, Cristina, Schatzberg, Alan F, Scheftner, William A, Schork, Nicholas J, Weickert, Cynthia Shannon, Foo, Jerome C, Shehktman, Tatyana, Shilling, Paul D, Sigurdsson, Engilbert, Slaney, Claire, Smeland, Olav B, Sobell, Janet L, Hansen, Christine Søholm, Spijker, Anne T, Clair, David St, Steffens, Michael, Streit, Fabian, Treutlein, Jens, Strauss, John S, Strohmaier, Jana, Szelinger, Szabolcs, Thompson, Robert C, EThorgeirsson, Thorgeir, Vedde, Helmut, Wang, Weiqing, Watson, Stanley J, Witt, Stephanie H, Weickert, Thomas W, Xi, Simon, Xu, Wei, Young, Allan H, Zandi, Peter, Zhang, Peng, Zollner, Sebastian, Adolfsson, Rolf, Agartz, Ingrid, Cichon, Sven, Alda, Martin, Backlund, Lena, Baune, Bernhard T, Bellivier, Frank, Berrettini, Wade H, Biernacka, Joanna M, Blackwood, Douglas H R, Boehnke, Michael, Børglum, Anders D, Corvin, Aiden, Craddock, Nicholas, Daly, Mark J, Dannlowski, Udo, Esko, Tõnu, Etain, Bruno, Frye, Mark, Fullerton, Janice M, Gershon, Elliot S, Gill, Michael, Goes, Fernando, Grigoroiu-Serbanescu, Maria, Hauser, Joanna, Hougaard, David M, Hultman, Christina M, Jones, Ian, Jones, Lisa A, Kahn, René S, Kirov, George, Landén, Mikael, Leboyer, Marion, Mayoral, Fermín, Lewis, Cathryn M, Li, Qingqin S, Lissowska, Jolanta, Martin, Nicholas G, Mayoral, Fermin, McElroy, Susan L, McIntosh, Andrew M, McMahon, Francis J, Melle, Ingrid, Metspalu, Andres, Müller-Myhsok, Bertram, Mitchell, Philip B, Morken, Gunnar, Mors, Ole, Mortensen, Preben Bo, Myers, Richard M, Neale, Benjamin M, Nimgaonkar, Vishwajit, Nordentoft, Merete, Nöthen, Markus M, Forstner, Andreas J, O'Donovan, Michael C, Oedegaard, Ketil J, Owen, Michael J, Paciga, Sara A, Pato, Carlos, Pato, Michele T, Posthuma, Danielle, Ramos-Quiroga, Josep Antoni, Ribasés, Marta, Rietschel, Marcella, Rouleau, Guy A, Schalling, Martin, Schofield, Peter R, Schulze, Thomas G, Serretti, Alessandro, Smoller, Jordan W, Stefansson, Hreinn, Stefansson, Kari, Stordal, Eystein, Sullivan, Patrick F, Turecki, Gustavo, Vaaler, Arne E, Vieta, Eduard, Vincent, John B, Werge, Thomas, Nurnberger, John I, Wray, Naomi R, Florio, Arianna Di, Edenberg, Howard J, Stahl, Eli A, Ophoff, Roel A, Scott, Laura J, Andreassen, Ole A, Kelsoe, John, Sklar, Pamela, Ripke, Stephan, Mattheisen, Manuel, Trzaskowski, Maciej, Byrne, Enda M, Breen, Gerome, Abdellaoui, Abdel, Adams, Mark J, Agerbo, Esben, Air, Tracy M, Bacanu, Silviu-Alin, Bækvad-Hansen, Marie, Beekman, Aartjan T F, Bigdeli, Tim B, Binder, Elisabeth B, Bryois, Julien, Buttenschøn, Henriette N, Bybjerg-Grauholm, Jonas, Cai, Na, Castelao, Enrique, Christensen, Jane Hvarregaard, Clarke, Toni-Kim, Coleman, Jonathan R I, Colodro-Conde, Lucía, Couvy-Duchesne, Baptiste, McQuillin, Andrew, Craddock, Nick, Crawford, Gregory E, Davies, Gail, Deary, Ian J, Derks, Eske M, Direk, Nese, Dolan, Conor V, Dunn, Erin C, Eley, Thalia C, Escott-Price, Valentina, Kiadeh, Farnush Farhadi Hassan, Finucane, Hilary K, Gaspar, Héléna A, Goes, Fernando S, Trubetskoy, Vassily, Hall, Lynsey S, Hansen, Thomas F, Hickie, Ian B, Homuth, Georg, Horn, Carsten, Hottenga, Jouke-Jan, Howard, David M, Ising, Marcus, Jansen, Rick, Jorgenson, Eric, Kohane, Isaac S, Kraft, Julia, Wang, Yunpeng, Kretzschmar, Warren W, Kutalik, Zoltán, Li, Yihan, Lind, Penelope A, MacKinnon, Dean F, Maier, Robert M, Marchini, Jonathan, Mbarek, Hamdi, McGrath, Patrick, Mehta, Divya, Middeldorp, Christel M, Mihailov, Evelin, Milaneschi, Yuri, Mondimore, Francis M, Mostafavi, Sara, Nauck, Matthias, Ng, Bernard, Nivard, Michel G, Nyholt, Dale R, O'Reilly, Paul F, Oskarsson, Hogni, Painter, Jodie N, González, Maria José, de Leeuw, Christiaan A, Pedersen, Carsten Bøcker, Peterson, Roseann E, Pettersson, Erik, Peyrot, Wouter J, Pistis, Giorgio, Quiroz, Jorge A, Qvist, Per, Steinberg, Stacy, Riley, Brien P, Mirza, Saira Saeed, Schoevers, Robert, Schulte, Eva C, Shen, Ling, Shi, Jianxin, Shyn, Stanley I, Sinnamon, Grant C B, Pavlides, Jennifer M Whitehead, Smit, Johannes H, Smith, Daniel J, Tansey, Katherine E, Teismann, Henning, Teumer, Alexander, Thompson, Wesley, Thomson, Pippa A, Thorgeirsson, Thorgeir E, Traylor, Matthew, Uitterlinden, André G, Umbricht, Daniel, Van der Auwera, Sandra, van Hemert, Albert M, Viktorin, Alexander, Pers, Tune H, Visscher, Peter M, Webb, Bradley T, Weinsheimer, Shantel Marie, Wellmann, Jürgen, Willemsen, Gonneke, Wu, Yang, Xi, Hualin S, Yang, Jian, Holmans, Peter A, Zhang, Futao, Arolt, Volker, Berger, Klaus, Boomsma, Dorret I, de Geus, E. J. C., DePaulo, J Raymond, Domenici, Enrico, Abbott, Liam, Domschke, Katharina, Grabe, Hans J, Hamilton, Steven P, Hayward, Caroline, Heath, Andrew C, Kendler, Kenneth S, Kloiber, Stefan, Lewis, Glyn, Madden, Pamela A F, Magnusson, Patrik K, Akil, Huda, Pedersen, Nancy L, Penninx, Brenda W J H, Porteous, David J, Preisig, Martin, Albani, Diego, Schaefer, Catherine, Tiemeier, Henning, Uher, Rudolf, Völzke, Henry, Weissman, Myrna M, Gil Flores, Susana, Alliey-Rodriguez, Ney, Levinson, Douglas F, Als, Thomas D, Anjorin, Adebayo, Antilla, Verneri, Awasthi, Swapnil, Badner, Judith A, Barchas, Jack D, Bass, Nicholas, Bauer, Michael, Cabaleiro Fabeiro, Francisco J, Belliveau, Richard, Bergen, Sarah E, Bøen, Erlend, Boks, Marco, Boocock, James, Budde, Monika, Bunney, William, Burmeister, Margit, Del Río Noriega, Francisco, Byerley, William, Casas, Miquel, Cerrato, Felecia, Cervantes, Pablo, Chambert, Kimberly, Charney, Alexander W, Chen, Danfeng, Churchhouse, Claire, Coryell, William, Perez, Fermin Perez, Craig, David W, Cruceanu, Cristiana, Czerski, Piotr M, Dale, Anders M, de Jong, Simone, Del-Favero, Jurgen, Djurovic, Srdjan, Dobbyn, Amanda L, Haro González, Jesus, Dumont, Ashley, Elvsåshagen, Torbjørn, Fan, Chun Chieh, Fischer, Sascha B, Flickinger, Matthew, Foroud, Tatiana M, Forty, Liz, Fraser, Christine, Psychiatry, APH - Mental Health, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Amsterdam Neuroscience - Complex Trait Genetics, Epidemiology and Data Science, APH - Digital Health, Andlauer T.F.M., Guzman-Parra J., Streit F., Strohmaier J., Gonzalez M.J., Gil Flores S., Cabaleiro Fabeiro F.J., del Rio Noriega F., Perez F.P., Haro Gonzalez J., Orozco Diaz G., de Diego-Otero Y., Moreno-Kustner B., Auburger G., Degenhardt F., Heilmann-Heimbach S., Herms S., Hoffmann P., Frank J., Foo J.C., Treutlein J., Witt S.H., Cichon S., Kogevinas M., Stahl E.A., Breen G., Forstner A.J., McQuillin A., Ripke S., Trubetskoy V., Mattheisen M., Wang Y., Coleman J.R.I., Gaspar H.A., de Leeuw C.A., Steinberg S., Pavlides J.M.W., Trzaskowski M., Pers T.H., Holmans P.A., Abbott L., Agerbo E., Akil H., Albani D., Alliey-Rodriguez N., Als T.D., Anjorin A., Antilla V., Awasthi S., Badner J.A., Baekvad-Hansen M., Barchas J.D., Bass N., Bauer M., Belliveau R., Bergen S.E., Pedersen C.B., Boen E., Boks M., Boocock J., Budde M., Bunney W., Burmeister M., Bybjerg-Grauholm J., Byerley W., Casas M., Cerrato F., Cervantes P., Chambert K., Charney A.W., Chen D., Churchhouse C., Clarke T.-K., Coryell W., Craig D.W., Cruceanu C., Czerski P.M., Dale A.M., de Jong S., Del-Favero J., DePaulo J.R., Djurovic S., Dobbyn A.L., Dumont A., Elvsashagen T., Escott-Price V., Fan C.C., Fischer S.B., Flickinger M., Foroud T.M., Forty L., Fraser C., Freimer N.B., Frisen L., Gade K., Gage D., Garnham J., Giambartolomei C., Pedersen M.G., Goldstein J., Gordon S.D., Gordon-Smith K., Green E.K., Green M.J., Greenwood T.A., Grove J., Guan W., Parra J.G., Hamshere M.L., Hautzinger M., Heilbronner U., Hipolito M., Holland D., Huckins L., Jamain S., Johnson J.S., Jureus A., Kandaswamy R., Karlsson R., Kennedy J.L., Kittel-Schneider S., Knowles J.A., Koller A.C., Kupka R., Lavebratt C., Lawrence J., Lawson W.B., Leber M., Lee P.H., Levy S.E., Li J.Z., Liu C., Lucae S., Maaser A., MacIntyre D.J., Mahon P.B., Maier W., Martinsson L., McCarroll S., McGuffin P., McInnis M.G., McKay J.D., Medeiros H., Medland S.E., Meng F., Milani L., Montgomery G.W., Morris D.W., Muhleisen T.W., Mullins N., Nguyen H., Nievergelt C.M., Adolfsson A.N., Nwulia E.A., O'Donovan C., Loohuis L.M.O., Ori A.P.S., Oruc L., Osby U., Perlis R.H., Perry A., Pfennig A., Potash J.B., Purcell S.M., Regeer E.J., Reif A., Reinbold C.S., Rice J.P., Richards A.L., Rivas F., Rivera M., Roussos P., Ruderfer D.M., Ryu E., Sanchez-Mora C., Schatzberg A.F., Scheftner W.A., Schork N.J., Weickert C.S., Shehktman T., Shilling P.D., Sigurdsson E., Slaney C., Smeland O.B., Sobell J.L., Hansen C.S., Spijker A.T., Clair D.S., Steffens M., Strauss J.S., Szelinger S., Thompson R.C., EThorgeirsson T., Vedde H., Wang W., Watson S.J., Weickert T.W., Xi S., Xu W., Young A.H., Zandi P., Zhang P., Zollner S., Adolfsson R., Agartz I., Alda M., Backlund L., Baune B.T., Bellivier F., Berrettini W.H., Biernacka J.M., Blackwood D.H.R., Boehnke M., Borglum A.D., Corvin A., Craddock N., Daly M.J., Dannlowski U., Esko T., Etain B., Frye M., Fullerton J.M., Gershon E.S., Gill M., Goes F., Grigoroiu-Serbanescu M., Hauser J., Hougaard D.M., Hultman C.M., Jones I., Jones L.A., Kahn R.S., Kirov G., Landen M., Leboyer M., Lewis C.M., Li Q.S., Lissowska J., Martin N.G., Mayoral F., McElroy S.L., McIntosh A.M., McMahon F.J., Melle I., Metspalu A., Mitchell P.B., Morken G., Mors O., Mortensen P.B., Muller-Myhsok B., Myers R.M., Neale B.M., Nimgaonkar V., Nordentoft M., Nothen M.M., O'Donovan M.C., Oedegaard K.J., Owen M.J., Paciga S.A., Pato C., Pato M.T., Posthuma D., Ramos-Quiroga J.A., Ribases M., Rietschel M., Rouleau G.A., Schalling M., Schofield P.R., Schulze T.G., Serretti A., Smoller J.W., Stefansson H., Stefansson K., Stordal E., Sullivan P.F., Turecki G., Vaaler A.E., Vieta E., Vincent J.B., Werge T., Nurnberger J.I., Wray N.R., Florio A.D., Edenberg H.J., Ophoff R.A., Scott L.J., Andreassen O.A., Kelsoe J., Sklar P., Byrne E.M., Abdellaoui A., Adams M.J., Air T.M., Bacanu S.-A., Beekman A.T.F., Bigdeli T.B., Binder E.B., Bryois J., Buttenschon H.N., Cai N., Castelao E., Christensen J.H., Colodro-Conde L., Couvy-Duchesne B., Crawford G.E., Davies G., Deary I.J., Derks E.M., Direk N., Dolan C.V., Dunn E.C., Eley T.C., Kiadeh F.F.H., Finucane H.K., Goes F.S., Hall L.S., Hansen T.F., Hickie I.B., Homuth G., Horn C., Hottenga J.-J., Howard D.M., Ising M., Jansen R., Jorgenson E., Kohane I.S., Hill, Kraft J., Kretzschmar W.W., Kutalik Z., Li Y., Lind P.A., MacKinnon D.F., Maier R.M., Marchini J., Mbarek H., McGrath P., Mehta D., Middeldorp C.M., Mihailov E., Milaneschi Y., Mondimore F.M., Mostafavi S., Nauck M., Ng B., Nivard M.G., Nyholt D.R., O'Reilly P.F., Oskarsson H., Painter J.N., Peterson R.E., Pettersson E., Peyrot W.J., Pistis G., Quiroz J.A., Qvist P., Riley B.P., Mirza S.S., Schoevers R., Schulte E.C., Shen L., Shi J., Shyn S.I., Sinnamon G.C.B., Smit J.H., Smith D.J., Tansey K.E., Teismann H., Teumer A., Thompson W., Thomson P.A., Thorgeirsson T.E., Traylor M., Uitterlinden A.G., Umbricht D., Van der Auwera S., van Hemert A.M., Viktorin A., Visscher P.M., Webb B.T., Weinsheimer S.M., Wellmann J., Willemsen G., Wu Y., Xi H.S., Yang J., Zhang F., Arolt V., Berger K., Boomsma D.I., de Geus E.J.C., Domenici E., Domschke K., Grabe H.J., Hamilton S.P., Hayward C., Heath A.C., Kendler K.S., Kloiber S., Lewis G., Madden P.A.F., Magnusson P.K., Pedersen N.L., Penninx B.W.J.H., Porteous D.J., Preisig M., Schaefer C., Tiemeier H., Uher R., Volzke H., Weissman M.M., Levinson D.F., Child and Adolescent Psychiatry / Psychology, Epidemiology, Internal Medicine, Clinical Cognitive Neuropsychiatry Research Program (CCNP), Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Læknadeild (HÍ), Faculty of Medicine (UI), Heilbrigðisvísindasvið (HÍ), School of Health Sciences (UI), Háskóli Íslands, University of Iceland, APH - Methodology, Biological Psychology, APH - Personalized Medicine, APH - Health Behaviors & Chronic Diseases, Complex Trait Genetics, and Adult Psychiatry

Subjects
Netherlands Twin Register (NTR), Genetic variants, Bipolar Disorder, Specific risk, Disease, 0302 clinical medicine, Multiplex, Genetic risk, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), Depression (differential diagnoses), 0303 health sciences, Depression, ddc, 3. Good health, Geðraskanir, Psychiatry and Mental health, Schizophrenia, Cohort, Major depressive disorder, Case-Control Studie, Human, medicine.medical_specialty, Bipolar disorder, Article, Cellular and Molecular Neuroscience, 03 medical and health sciences, Geðklofi, SDG 3 - Good Health and Well-being, medicine, Humans, Genetic Predisposition to Disease, ddc:610, Psychiatry, Þunglyndi, Molecular Biology, 030304 developmental biology, Depressive Disorder, Major, Geðhvarfasýki, business.industry, Psychiatric disorder, medicine.disease, Genarannsóknir, Case-Control Studies, Multiple comparisons problem, business, 030217 neurology & neurosurgery
Abstract

Publisher's version, Multiplex families with a high prevalence of a psychiatric disorder are often examined to identify rare genetic variants with large effect sizes. In the present study, we analysed whether the risk for bipolar disorder (BD) in BD multiplex families is influenced by common genetic variants. Furthermore, we investigated whether this risk is conferred mainly by BD-specific risk variants or by variants also associated with the susceptibility to schizophrenia or major depression. In total, 395 individuals from 33 Andalusian BD multiplex families (166 BD, 78 major depressive disorder, 151 unaffected) as well as 438 subjects from an independent, BD case/control cohort (161 unrelated BD, 277 unrelated controls) were analysed. Polygenic risk scores (PRS) for BD, schizophrenia (SCZ), and major depression were calculated and compared between the cohorts. Both the familial BD cases and unaffected family members had higher PRS for all three psychiatric disorders than the independent controls, with BD and SCZ being significant after correction for multiple testing, suggesting a high baseline risk for several psychiatric disorders in the families. Moreover, familial BD cases showed significantly higher BD PRS than unaffected family members and unrelated BD cases. A plausible hypothesis is that, in multiplex families with a general increase in risk for psychiatric disease, BD development is attributable to a high burden of common variants that confer a specific risk for BD. The present analyses demonstrated that common genetic risk variants for psychiatric disorders are likely to contribute to the high incidence of affective psychiatric disorders in the multiplex families. However, the PRS explained only part of the observed phenotypic variance, and rare variants might have also contributed to disease development., The study was supported by the German Federal Ministry of Education and Research (BMBF), through the Integrated Network IntegraMent, under the auspices of the e:Med programme (grants 01ZX1314A to MMN and SC; 01ZX1314G to MR; 01ZX1614J to BMM) through grants 01EE1406C to MR and 01EE1409C to MR and SHW, and through ERA-NET NEURON, “SynSchiz—Linking synaptic dysfunction to disease mechanisms in schizophrenia—a multilevel investigation” (01EW1810 to MR) and BMBF grants 01EE1409C and 01EE1406C to MR and SHW; by the German Research Foundation (DFG grants FOR2107; RI908/11-2 to MR; NO246/10-2 to MMN; MU1315/8-2 to BMM; WI 3439/3-2 to SHW), by the Andalusian regional Health and Innovation Government (grants PI-0060-2017, RC-0006-2015 the Nicolas Monarde Programme for YDO and CTS-546) and by the Swiss National Science Foundation (SNSF grant 156791 to SC). MMN is a member of the DFG-funded cluster of excellence ImmunoSensation. The PGC has received major funding from the US National Institute of Mental Health and the US National Institute of Drug Abuse (U01 MH109528 and U01 MH1095320). We thank the research participants and employees of 23andMe, Inc. for their contribution to the MDD meta-analysis published in [14]. We thank the International Genomics of Alzheimer's Project (IGAP) for providing summary results data for the present analyses. See the Supplementary Data for extended Acknowledgements.

Published
2021

26. Comorbid medical illness in bipolar disorder

Author

Forty, Liz, Ulanova, Anna, Jones, Lisa, Jones, Ian, Gordon-Smith, Katherine, Fraser, Christine, Farmer, Anne, McGuffin, Peter, Lewis, Cathryn M., Hosang, Georgina M., Rivera, Margarita, and Craddock, Nick

Published
2014

27. Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders

Author

Andlauer, Till F.M., Guzman-Parra, Jose, Streit, Fabian, Strohmaier, Jana, González, Maria José, Gil Flores, Susana, Cabaleiro Fabeiro, Francisco J., del Río Noriega, Francisco, Perez, Fermin Perez, Haro González, Jesus, Orozco Diaz, Guillermo, de Diego-Otero, Yolanda, Moreno-Küstner, Berta, Auburger, Georg, Degenhardt, Franziska, Heilmann-Heimbach, Stefanie, Herms, Stefan, Hoffmann, Per, Frank, Josef, Foo, Jerome C., Treutlein, Jens, Witt, Stephanie H., Cichon, Sven, Kogevinas, Manolis, Stahl, Eli A., Breen, Gerome, Forstner, Andreas J., McQuillin, Andrew, Ripke, Stephan, Trubetskoy, Vassily, Mattheisen, Manuel, Wang, Yunpeng, Coleman, Jonathan R.I., Gaspar, Héléna A., de Leeuw, Christiaan A., Steinberg, Stacy, Pavlides, Jennifer M.Whitehead, Trzaskowski, Maciej, Pers, Tune H., Holmans, Peter A., Abbott, Liam, Agerbo, Esben, Akil, Huda, Albani, Diego, Alliey-Rodriguez, Ney, Als, Thomas D., Anjorin, Adebayo, Antilla, Verneri, Awasthi, Swapnil, Badner, Judith A., Bækvad-Hansen, Marie, Barchas, Jack D., Bass, Nicholas, Bauer, Michael, Belliveau, Richard, Bergen, Sarah E., Pedersen, Carsten Bøcker, Bøen, Erlend, Boks, Marco, Boocock, James, Budde, Monika, Bunney, William, Burmeister, Margit, Bybjerg-Grauholm, Jonas, Byerley, William, Casas, Miquel, Cerrato, Felecia, Cervantes, Pablo, Chambert, Kimberly, Charney, Alexander W., Chen, Danfeng, Churchhouse, Claire, Clarke, Toni Kim, Coryell, William, Craig, David W., Cruceanu, Cristiana, Czerski, Piotr M., Dale, Anders M., de Jong, Simone, Del-Favero, Jurgen, DePaulo, J. Raymond, Djurovic, Srdjan, Dobbyn, Amanda L., Dumont, Ashley, Elvsåshagen, Torbjørn, Escott-Price, Valentina, Fan, Chun Chieh, Fischer, Sascha B., Flickinger, Matthew, Foroud, Tatiana M., Forty, Liz, Fraser, Christine, Freimer, Nelson B., Frisén, Louise, Gade, Katrin, Gage, Diane, Garnham, Julie, Giambartolomei, Claudia, Pedersen, Marianne Giørtz, Goldstein, Jaqueline, Gordon, Scott D., Gordon-Smith, Katherine, Green, Elaine K., Green, Melissa J., Greenwood, Tiffany A., Grove, Jakob, Guan, Weihua, Parra, José Guzman, Hamshere, Marian L., Hautzinger, Martin, Heilbronner, Urs, Hipolito, Maria, Holland, Dominic, Huckins, Laura, Jamain, Stéphane, Johnson, Jessica S., Juréus, Anders, Kandaswamy, Radhika, Karlsson, Robert, Kennedy, James L., Kittel-Schneider, Sarah, Knowles, James A., Koller, Anna C., Kupka, Ralph, Lavebratt, Catharina, Lawrence, Jacob, Lawson, William B., Leber, Markus, Lee, Phil H., Levy, Shawn E., Li, Jun Z., Liu, Chunyu, Lucae, Susanne, Maaser, Anna, MacIntyre, Donald J., Mahon, Pamela B., Maier, Wolfgang, Martinsson, Lina, McCarroll, Steve, McGuffin, Peter, McInnis, Melvin G., McKay, James D., Medeiros, Helena, Medland, Sarah E., Meng, Fan, Milani, Lili, Montgomery, Grant W., Morris, Derek W., Mühleisen, Thomas W., Mullins, Niamh, Nguyen, Hoang, Nievergelt, Caroline M., Adolfsson, Annelie Nordin, Nwulia, Evaristus A., O’Donovan, Claire, Loohuis, Loes M.Olde, Ori, Anil P.S., Oruc, Lilijana, Ösby, Urban, Perlis, Roy H., Perry, Amy, Pfennig, Andrea, Potash, James B., Purcell, Shaun M., Regeer, Eline J., Reif, Andreas, Reinbold, Céline S., Rice, John P., Richards, Alexander L., Rivas, Fabio, Rivera, Margarita, Roussos, Panos, Ruderfer, Douglas M., Ryu, Euijung, Sánchez-Mora, Cristina, Schatzberg, Alan F., Scheftner, William A., Schork, Nicholas J., Weickert, Cynthia Shannon, Shehktman, Tatyana, Shilling, Paul D., Sigurdsson, Engilbert, Slaney, Claire, Smeland, Olav B., Sobell, Janet L., Hansen, Christine Søholm, Spijker, Anne T., Clair, David St, Steffens, Michael, Strauss, John S., Szelinger, Szabolcs, Thompson, Robert C., EThorgeirsson, Thorgeir, Vedde, Helmut, Wang, Weiqing, Watson, Stanley J., Weickert, Thomas W., Xi, Simon, Xu, Wei, Young, Allan H., Zandi, Peter, Zhang, Peng, Zollner, Sebastian, Adolfsson, Rolf, Agartz, Ingrid, Alda, Martin, Backlund, Lena, Baune, Bernhard T., Bellivier, Frank, Berrettini, Wade H., Biernacka, Joanna M., Blackwood, Douglas H.R., Boehnke, Michael, Børglum, Anders D., Corvin, Aiden, Craddock, Nicholas, Daly, Mark J., Dannlowski, Udo, Esko, Tõnu, Etain, Bruno, Frye, Mark, Fullerton, Janice M., Gill, Michael, Martin, Nicholas G., Schofield, Peter R., Sullivan, Patrick F., Adams, Mark J., Colodro-Conde, Lucía, Derks, Eske M., Howard, David M., Lind, Penelope A., Mehta, Divya, Nyholt, Dale R., Smith, Daniel J., Visscher, Peter M., other, and, Andlauer, Till F.M., Guzman-Parra, Jose, Streit, Fabian, Strohmaier, Jana, González, Maria José, Gil Flores, Susana, Cabaleiro Fabeiro, Francisco J., del Río Noriega, Francisco, Perez, Fermin Perez, Haro González, Jesus, Orozco Diaz, Guillermo, de Diego-Otero, Yolanda, Moreno-Küstner, Berta, Auburger, Georg, Degenhardt, Franziska, Heilmann-Heimbach, Stefanie, Herms, Stefan, Hoffmann, Per, Frank, Josef, Foo, Jerome C., Treutlein, Jens, Witt, Stephanie H., Cichon, Sven, Kogevinas, Manolis, Stahl, Eli A., Breen, Gerome, Forstner, Andreas J., McQuillin, Andrew, Ripke, Stephan, Trubetskoy, Vassily, Mattheisen, Manuel, Wang, Yunpeng, Coleman, Jonathan R.I., Gaspar, Héléna A., de Leeuw, Christiaan A., Steinberg, Stacy, Pavlides, Jennifer M.Whitehead, Trzaskowski, Maciej, Pers, Tune H., Holmans, Peter A., Abbott, Liam, Agerbo, Esben, Akil, Huda, Albani, Diego, Alliey-Rodriguez, Ney, Als, Thomas D., Anjorin, Adebayo, Antilla, Verneri, Awasthi, Swapnil, Badner, Judith A., Bækvad-Hansen, Marie, Barchas, Jack D., Bass, Nicholas, Bauer, Michael, Belliveau, Richard, Bergen, Sarah E., Pedersen, Carsten Bøcker, Bøen, Erlend, Boks, Marco, Boocock, James, Budde, Monika, Bunney, William, Burmeister, Margit, Bybjerg-Grauholm, Jonas, Byerley, William, Casas, Miquel, Cerrato, Felecia, Cervantes, Pablo, Chambert, Kimberly, Charney, Alexander W., Chen, Danfeng, Churchhouse, Claire, Clarke, Toni Kim, Coryell, William, Craig, David W., Cruceanu, Cristiana, Czerski, Piotr M., Dale, Anders M., de Jong, Simone, Del-Favero, Jurgen, DePaulo, J. Raymond, Djurovic, Srdjan, Dobbyn, Amanda L., Dumont, Ashley, Elvsåshagen, Torbjørn, Escott-Price, Valentina, Fan, Chun Chieh, Fischer, Sascha B., Flickinger, Matthew, Foroud, Tatiana M., Forty, Liz, Fraser, Christine, Freimer, Nelson B., Frisén, Louise, Gade, Katrin, Gage, Diane, Garnham, Julie, Giambartolomei, Claudia, Pedersen, Marianne Giørtz, Goldstein, Jaqueline, Gordon, Scott D., Gordon-Smith, Katherine, Green, Elaine K., Green, Melissa J., Greenwood, Tiffany A., Grove, Jakob, Guan, Weihua, Parra, José Guzman, Hamshere, Marian L., Hautzinger, Martin, Heilbronner, Urs, Hipolito, Maria, Holland, Dominic, Huckins, Laura, Jamain, Stéphane, Johnson, Jessica S., Juréus, Anders, Kandaswamy, Radhika, Karlsson, Robert, Kennedy, James L., Kittel-Schneider, Sarah, Knowles, James A., Koller, Anna C., Kupka, Ralph, Lavebratt, Catharina, Lawrence, Jacob, Lawson, William B., Leber, Markus, Lee, Phil H., Levy, Shawn E., Li, Jun Z., Liu, Chunyu, Lucae, Susanne, Maaser, Anna, MacIntyre, Donald J., Mahon, Pamela B., Maier, Wolfgang, Martinsson, Lina, McCarroll, Steve, McGuffin, Peter, McInnis, Melvin G., McKay, James D., Medeiros, Helena, Medland, Sarah E., Meng, Fan, Milani, Lili, Montgomery, Grant W., Morris, Derek W., Mühleisen, Thomas W., Mullins, Niamh, Nguyen, Hoang, Nievergelt, Caroline M., Adolfsson, Annelie Nordin, Nwulia, Evaristus A., O’Donovan, Claire, Loohuis, Loes M.Olde, Ori, Anil P.S., Oruc, Lilijana, Ösby, Urban, Perlis, Roy H., Perry, Amy, Pfennig, Andrea, Potash, James B., Purcell, Shaun M., Regeer, Eline J., Reif, Andreas, Reinbold, Céline S., Rice, John P., Richards, Alexander L., Rivas, Fabio, Rivera, Margarita, Roussos, Panos, Ruderfer, Douglas M., Ryu, Euijung, Sánchez-Mora, Cristina, Schatzberg, Alan F., Scheftner, William A., Schork, Nicholas J., Weickert, Cynthia Shannon, Shehktman, Tatyana, Shilling, Paul D., Sigurdsson, Engilbert, Slaney, Claire, Smeland, Olav B., Sobell, Janet L., Hansen, Christine Søholm, Spijker, Anne T., Clair, David St, Steffens, Michael, Strauss, John S., Szelinger, Szabolcs, Thompson, Robert C., EThorgeirsson, Thorgeir, Vedde, Helmut, Wang, Weiqing, Watson, Stanley J., Weickert, Thomas W., Xi, Simon, Xu, Wei, Young, Allan H., Zandi, Peter, Zhang, Peng, Zollner, Sebastian, Adolfsson, Rolf, Agartz, Ingrid, Alda, Martin, Backlund, Lena, Baune, Bernhard T., Bellivier, Frank, Berrettini, Wade H., Biernacka, Joanna M., Blackwood, Douglas H.R., Boehnke, Michael, Børglum, Anders D., Corvin, Aiden, Craddock, Nicholas, Daly, Mark J., Dannlowski, Udo, Esko, Tõnu, Etain, Bruno, Frye, Mark, Fullerton, Janice M., Gill, Michael, Martin, Nicholas G., Schofield, Peter R., Sullivan, Patrick F., Adams, Mark J., Colodro-Conde, Lucía, Derks, Eske M., Howard, David M., Lind, Penelope A., Mehta, Divya, Nyholt, Dale R., Smith, Daniel J., Visscher, Peter M., and other, and

Abstract

Multiplex families with a high prevalence of a psychiatric disorder are often examined to identify rare genetic variants with large effect sizes. In the present study, we analysed whether the risk for bipolar disorder (BD) in BD multiplex families is influenced by common genetic variants. Furthermore, we investigated whether this risk is conferred mainly by BD-specific risk variants or by variants also associated with the susceptibility to schizophrenia or major depression. In total, 395 individuals from 33 Andalusian BD multiplex families (166 BD, 78 major depressive disorder, 151 unaffected) as well as 438 subjects from an independent, BD case/control cohort (161 unrelated BD, 277 unrelated controls) were analysed. Polygenic risk scores (PRS) for BD, schizophrenia (SCZ), and major depression were calculated and compared between the cohorts. Both the familial BD cases and unaffected family members had higher PRS for all three psychiatric disorders than the independent controls, with BD and SCZ being significant after correction for multiple testing, suggesting a high baseline risk for several psychiatric disorders in the families. Moreover, familial BD cases showed significantly higher BD PRS than unaffected family members and unrelated BD cases. A plausible hypothesis is that, in multiplex families with a general increase in risk for psychiatric disease, BD development is attributable to a high burden of common variants that confer a specific risk for BD. The present analyses demonstrated that common genetic risk variants for psychiatric disorders are likely to contribute to the high incidence of affective psychiatric disorders in the multiplex families. However, the PRS explained only part of the observed phenotypic variance, and rare variants might have also contributed to disease development.

Published
2021

28. Genetic associations between childhood psychopathology and adult depression and associated traits in 42 998 individuals

Author

Akingbuwa, Wonuola A., Hammerschlag, Anke R., Jami, Eshim S., Allegrini, Andrea G., Karhunen, Ville, Sallis, Hannah, Ask, Helga, Askeland, Ragna B., Baselmans, Bart, Diemer, Elizabeth, Hagenbeek, Fiona A., Havdahl, Alexandra, Hottenga, Jouke-Jan, Mbarek, Hamdi, Rivadeneira, Fernando, Tesli, Martin, van Beijsterveldt, Catharina, Breen, Gerome, Lewis, Cathryn M., Thapar, Anita, Boomsma, Dorret I., Kuja-Halkola, Ralf, Reichborn-Kjennerud, Ted, Magnus, Per, Rimfeld, Kaili, Ystrom, Eivind, Jarvelin, Marjo-Riitta, Lichtenstein, Paul, Lundstrom, Sebastian, Munafò, Marcus R., Plomin, Robert, Tiemeier, Henning, Nivard, Michel G., Bartels, Meike, Middeldorp, Christel M., Holmans, Peter A., Richards, Alexander L., Escott-Price, Valentina, Forty, Liz, Fraser, Christine, Hamshere, Marian L., Craddock, Nicholas, Jones, Ian, Kirov, George, O'Donovan, Michael C., Owen, Michael J., Di Florio, Arianna, Tansey, Katherine E., and The Bipolar Disorder and Major Depressive Disorder Working Group

Abstract

Importance Adult mood disorders are often preceded by behavioral and emotional problems in childhood. It is yet unclear what explains the associations between childhood psychopathology and adult traits. Objective To investigate whether genetic risk for adult mood disorders and associated traits is associated with childhood disorders. Design, Setting, and Participants This meta-analysis examined data from 7 ongoing longitudinal birth and childhood cohorts from the UK, the Netherlands, Sweden, Norway, and Finland. Starting points of data collection ranged from July 1985 to April 2002. Participants were repeatedly assessed for childhood psychopathology from ages 6 to 17 years. Data analysis occurred from September 2017 to May 2019. Exposures Individual polygenic scores (PGS) were constructed in children based on genome-wide association studies of adult major depression, bipolar disorder, subjective well-being, neuroticism, insomnia, educational attainment, and body mass index (BMI). Main Outcomes and MeasuresRegression meta-analyses were used to test associations between PGS and attention-deficit/hyperactivity disorder (ADHD) symptoms and internalizing and social problems measured repeatedly across childhood and adolescence and whether these associations depended on childhood phenotype, age, and rater. Results The sample included 42 998 participants aged 6 to 17 years. Male participants varied from 43.0% (1040 of 2417 participants) to 53.1% (2434 of 4583 participants) by age and across all cohorts. The PGS of adult major depression, neuroticism, BMI, and insomnia were positively associated with childhood psychopathology (β estimate range, 0.023-0.042 [95% CI, 0.017–0.049]), while associations with PGS of subjective well-being and educational attainment were negative (β, −0.026 to −0.046 [95% CI, −0.020 to −0.057]). There was no moderation of age, type of childhood phenotype, or rater with the associations. The exceptions were stronger associations between educational attainment PGS and ADHD compared with internalizing problems (Δβ, 0.0561 [Δ95% CI, 0.0318-0.0804]; ΔSE, 0.0124) and social problems (Δβ, 0.0528 [Δ95% CI, 0.0282-0.0775]; ΔSE, 0.0126), and between BMI PGS and ADHD and social problems (Δβ, −0.0001 [Δ95% CI, −0.0102 to 0.0100]; ΔSE, 0.0052), compared with internalizing problems (Δβ, −0.0310 [Δ95% CI, −0.0456 to −0.0164]; ΔSE, 0.0074). Furthermore, the association between educational attainment PGS and ADHD increased with age (Δβ, −0.0032 [Δ 95% CI, −0.0048 to −0.0017]; ΔSE, 0.0008). Conclusions and Relevance Results from this study suggest the existence of a set of genetic factors influencing a range of traits across the life span with stable associations present throughout childhood. Knowledge of underlying mechanisms may affect treatment and long-term outcomes of individuals with psychopathology.

Published
2020

29. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

Author

Burton, Paul R., Clayton, David G., Cardon, Lon R., Craddock, Nick, Deloukas, Panos, Duncanson, Audrey, Kwiatkowski, Dominic P., McCarthy, Mark I., Ouwehand, Willem H., Samani, Nilesh J., Todd, John A., Donnelly, Peter, Barrett, Jeffrey C., Davison, Dan, Easton, Doug, Evans, David, Leung, Hin-Tak, Marchini, Jonathan L., Morris, Andrew P., Spencer, Chris C. A., Tobin, Martin D., Attwood, Antony P., Boorman, James P., Cant, Barbara, Everson, Ursula, Hussey, Judith M., Jolley, Jennifer D., Knight, Alexandra S., Koch, Kerstin, Meech, Elizabeth, Nutland, Sarah, Prowse, Christopher V., Stevens, Helen E., Taylor, Niall C., Walters, Graham R., Walker, Neil M., Watkins, Nicholas A., Winzer, Thilo, Jones, Richard W., McArdle, Wendy L., Ring, Susan M., Strachan, David P., Pembrey, Marcus, Breen, Gerome, St Clair, David, Caesar, Sian, Gordon-Smith, Katherine, Jones, Lisa, Fraser, Christine, Green, Elaine K., Grozeva, Detelina, Hamshere, Marian L., Holmans, Peter A., Jones, Ian R., Kirov, George, Moskvina, Valentina, Nikolov, Ivan, O'Donovan, Michael C., Owen, Michael J., Collier, David A., Elkin, Amanda, Farmer, Anne, Williamson, Richard, McGuffin, Peter, Young, Allan H., Ferrier, I. Nicol, Ball, Stephen G., Balmforth, Anthony J., Barrett, Jennifer H., Bishop, D. Timothy, Iles, Mark M., Maqbool, Azhar, Yuldasheva, Nadira, Hall, Alistair S., Braund, Peter S., Dixon, Richard J., Mangino, Massimo, Stevens, Suzanne, Thompson, John R., Bredin, Francesca, Tremelling, Mark, Parkes, Miles, Drummond, Hazel, Lees, Charles W., Nimmo, Elaine R., Satsangi, Jack, Fisher, Sheila A., Forbes, Alastair, Lewis, Cathryn M., Onnie, Clive M., Prescott, Natalie J., Sanderson, Jeremy, Mathew, Christopher G., Barbour, Jamie, Mohiuddin, M. Khalid, Todhunter, Catherine E., Mansfield, John C., Ahmad, Tariq, Cummings, Fraser R., Jewell, Derek P., Webster, John, Brown, Morris J., Lathrop, G. Mark, Connell, John, Dominiczak, Anna, Marcano, Carolina A. Braga, Burke, Beverley, Dobson, Richard, Gungadoo, Johannie, Lee, Kate L., Munroe, Patricia B., Newhouse, Stephen J., Onipinla, Abiodun, Wallace, Chris, Xue, Mingzhan, Caulfield, Mark, Farrall, Martin, Barton, Anne, Bruce, Ian N., Donovan, Hannah, Eyre, Steve, Gilbert, Paul D., Hider, Samantha L., Hinks, Anne M., John, Sally L., Potter, Catherine, Silman, Alan J., Symmons, Deborah P. M., Thomson, Wendy, Worthington, Jane, Dunger, David B., Widmer, Barry, Frayling, Timothy M., Freathy, Rachel M., Lango, Hana, Perry, John R. B., Shields, Beverley M., Weedon, Michael N., Hattersley, Andrew T., Hitman, Graham A., Walker, Mark, Elliott, Kate S., Groves, Christopher J., Lindgren, Cecilia M., Rayner, Nigel W., Timpson, Nicholas J., Zeggini, Eleftheria, Newport, Melanie, Sirugo, Giorgio, Lyons, Emily, Vannberg, Fredrik, Hill, Adrian V. S., Bradbury, Linda A., Farrar, Claire, Pointon, Jennifer J., Wordsworth, Paul, Brown, Matthew A., Franklyn, Jayne A., Heward, Joanne M., Simmonds, Matthew J., Gough, Stephen C. L., Seal, Sheila, Stratton, Michael R., Rahman, Nazneen, Ban, Maria, Goris, An, Sawcer, Stephen J., Compston, Alastair, Conway, David, Jallow, Muminatou, Rockett, Kirk A., Bumpstead, Suzannah J., Chaney, Amy, Downes, Kate, Ghori, Mohammed J. R., Gwilliam, Rhian, Hunt, Sarah E., Inouye, Michael, Keniry, Andrew, King, Emma, McGinnis, Ralph, Potter, Simon, Ravindrarajah, Rathi, Whittaker, Pamela, Widden, Claire, Withers, David, Cardin, Niall J., Ferreira, Teresa, Pereira-Gale, Joanne, Hallgrimsdottir, Ingileif B., Howie, Bryan N., Su, Zhan, Teo, Yik Ying, Vukcevic, Damjan, Bentley, David, and Compston, Alistair

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): The Wellcome Trust Case Control Consortium; Management Committee; Paul R. Burton [1]; David G. Clayton [2]; Lon R. Cardon [3]; Nick Craddock [4]; Panos Deloukas [5]; Audrey Duncanson [6]; [...]

Published
2007
Full Text
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32. The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls

Author

Coleman, Jonathan R.I., primary, Gaspar, Héléna A., additional, Bryois, Julien, additional, Breen, Gerome, additional, Byrne, Enda M., additional, Forstner, Andreas J., additional, Holmans, Peter A., additional, de Leeuw, Christiaan A., additional, Mattheisen, Manuel, additional, McQuillin, Andrew, additional, Whitehead Pavlides, Jennifer M., additional, Pers, Tune H., additional, Ripke, Stephan, additional, Stahl, Eli A., additional, Steinberg, Stacy, additional, Trubetskoy, Vassily, additional, Trzaskowski, Maciej, additional, Wang, Yunpeng, additional, Abbott, Liam, additional, Abdellaoui, Abdel, additional, Adams, Mark J., additional, Adolfsson, Annelie Nordin, additional, Agerbo, Esben, additional, Akil, Huda, additional, Albani, Diego, additional, Alliey-Rodriguez, Ney, additional, Als, Thomas D., additional, Andlauer, Till F.M., additional, Anjorin, Adebayo, additional, Antilla, Verneri, additional, Van der Auwera, Sandra, additional, Awasthi, Swapnil, additional, Bacanu, Silviu-Alin, additional, Badner, Judith A., additional, Bækvad-Hansen, Marie, additional, Barchas, Jack D., additional, Bass, Nicholas, additional, Bauer, Michael, additional, Beekman, Aartjan T.F., additional, Belliveau, Richard, additional, Bergen, Sarah E., additional, Bigdeli, Tim B., additional, Binder, Elisabeth B., additional, Bøen, Erlend, additional, Boks, Marco, additional, Boocock, James, additional, Budde, Monika, additional, Bunney, William, additional, Burmeister, Margit, additional, Buttenschøn, Henriette N., additional, Bybjerg-Grauholm, Jonas, additional, Byerley, William, additional, Cai, Na, additional, Casas, Miquel, additional, Castelao, Enrique, additional, Cerrato, Felecia, additional, Cervantes, Pablo, additional, Chambert, Kimberly, additional, Charney, Alexander W., additional, Chen, Danfeng, additional, Christensen, Jane Hvarregaard, additional, Churchhouse, Claire, additional, St Clair, David, additional, Clarke, Toni-Kim, additional, Colodro-Conde, Lucía, additional, Coryell, William, additional, Couvy-Duchesne, Baptiste, additional, Craig, David W., additional, Crawford, Gregory E., additional, Cruceanu, Cristiana, additional, Czerski, Piotr M., additional, Dale, Anders M., additional, Davies, Gail, additional, Deary, Ian J., additional, Degenhardt, Franziska, additional, Del-Favero, Jurgen, additional, DePaulo, J Raymond, additional, Derks, Eske M., additional, Direk, Nese, additional, Djurovic, Srdjan, additional, Dobbyn, Amanda L., additional, Dolan, Conor V., additional, Dumont, Ashley, additional, Dunn, Erin C., additional, Eley, Thalia C., additional, Elvsåshagen, Torbjørn, additional, Escott-Price, Valentina, additional, Fan, Chun Chieh, additional, Finucane, Hilary K., additional, Fischer, Sascha B., additional, Flickinger, Matthew, additional, Foo, Jerome C., additional, Foroud, Tatiana M., additional, Forty, Liz, additional, Frank, Josef, additional, Fraser, Christine, additional, Freimer, Nelson B., additional, Frisén, Louise, additional, Gade, Katrin, additional, Gage, Diane, additional, Garnham, Julie, additional, Giambartolomei, Claudia, additional, Goes, Fernando S., additional, Goldstein, Jaqueline, additional, Gordon, Scott D., additional, Gordon-Smith, Katherine, additional, Green, Elaine K., additional, Green, Melissa J., additional, Greenwood, Tiffany A., additional, Grove, Jakob, additional, Guan, Weihua, additional, Hall, Lynsey S., additional, Hamshere, Marian L., additional, Hansen, Christine Søholm, additional, Hansen, Thomas F., additional, Hautzinger, Martin, additional, Heilbronner, Urs, additional, van Hemert, Albert M., additional, Herms, Stefan, additional, Hickie, Ian B., additional, Hipolito, Maria, additional, Hoffmann, Per, additional, Holland, Dominic, additional, Homuth, Georg, additional, Horn, Carsten, additional, Hottenga, Jouke-Jan, additional, Huckins, Laura, additional, Ising, Marcus, additional, Jamain, Stéphane, additional, Jansen, Rick, additional, Johnson, Jessica S., additional, de Jong, Simone, additional, Jorgenson, Eric, additional, Juréus, Anders, additional, Kandaswamy, Radhika, additional, Karlsson, Robert, additional, Kennedy, James L., additional, Hassan Kiadeh, Farnush Farhadi, additional, Kittel-Schneider, Sarah, additional, Knowles, James A., additional, Kogevinas, Manolis, additional, Kohane, Isaac S., additional, Koller, Anna C., additional, Kraft, Julia, additional, Kretzschmar, Warren W., additional, Krogh, Jesper, additional, Kupka, Ralph, additional, Kutalik, Zoltán, additional, Lavebratt, Catharina, additional, Lawrence, Jacob, additional, Lawson, William B., additional, Leber, Markus, additional, Lee, Phil H., additional, Levy, Shawn E., additional, Li, Jun Z., additional, Li, Yihan, additional, Lind, Penelope A., additional, Liu, Chunyu, additional, Olde Loohuis, Loes M., additional, Maaser, Anna, additional, MacIntyre, Donald J., additional, MacKinnon, Dean F., additional, Mahon, Pamela B., additional, Maier, Wolfgang, additional, Maier, Robert M., additional, Marchini, Jonathan, additional, Martinsson, Lina, additional, Mbarek, Hamdi, additional, McCarroll, Steve, additional, McGrath, Patrick, additional, McGuffin, Peter, additional, McInnis, Melvin G., additional, McKay, James D., additional, Medeiros, Helena, additional, Medland, Sarah E., additional, Mehta, Divya, additional, Meng, Fan, additional, Middeldorp, Christel M., additional, Mihailov, Evelin, additional, Milaneschi, Yuri, additional, Milani, Lili, additional, Mirza, Saira Saeed, additional, Mondimore, Francis M., additional, Montgomery, Grant W., additional, Morris, Derek W., additional, Mostafavi, Sara, additional, Mühleisen, Thomas W., additional, Mullins, Niamh, additional, Nauck, Matthias, additional, Ng, Bernard, additional, Nguyen, Hoang, additional, Nievergelt, Caroline M., additional, Nivard, Michel G., additional, Nwulia, Evaristus A., additional, Nyholt, Dale R., additional, O'Donovan, Claire, additional, O'Reilly, Paul F., additional, Ori, Anil P.S., additional, Oruc, Lilijana, additional, Ösby, Urban, additional, Oskarsson, Hogni, additional, Painter, Jodie N., additional, Parra, José Guzman, additional, Pedersen, Carsten Bøcker, additional, Pedersen, Marianne Giørtz, additional, Perry, Amy, additional, Peterson, Roseann E., additional, Pettersson, Erik, additional, Peyrot, Wouter J., additional, Pfennig, Andrea, additional, Pistis, Giorgio, additional, Purcell, Shaun M., additional, Quiroz, Jorge A., additional, Qvist, Per, additional, Regeer, Eline J., additional, Reif, Andreas, additional, Reinbold, Céline S., additional, Rice, John P., additional, Riley, Brien P., additional, Rivas, Fabio, additional, Rivera, Margarita, additional, Roussos, Panos, additional, Ruderfer, Douglas M., additional, Ryu, Euijung, additional, Sánchez-Mora, Cristina, additional, Schatzberg, Alan F., additional, Scheftner, William A., additional, Schoevers, Robert, additional, Schork, Nicholas J., additional, Schulte, Eva C., additional, Shehktman, Tatyana, additional, Shen, Ling, additional, Shi, Jianxin, additional, Shilling, Paul D., additional, Shyn, Stanley I., additional, Sigurdsson, Engilbert, additional, Slaney, Claire, additional, Smeland, Olav B., additional, Smit, Johannes H., additional, Smith, Daniel J., additional, Sobell, Janet L., additional, Spijker, Anne T., additional, Steffens, Michael, additional, Strauss, John S., additional, Streit, Fabian, additional, Strohmaier, Jana, additional, Szelinger, Szabolcs, additional, Tansey, Katherine E., additional, Teismann, Henning, additional, Teumer, Alexander, additional, Thompson, Robert C., additional, Thompson, Wesley, additional, Thomson, Pippa A., additional, Thorgeirsson, Thorgeir E., additional, Traylor, Matthew, additional, Treutlein, Jens, additional, Uitterlinden, André G., additional, Umbricht, Daniel, additional, Vedder, Helmut, additional, Viktorin, Alexander, additional, Visscher, Peter M., additional, Wang, Weiqing, additional, Watson, Stanley J., additional, Webb, Bradley T., additional, Weickert, Cynthia Shannon, additional, Weickert, Thomas W., additional, Weinsheimer, Shantel Marie, additional, Wellmann, Jürgen, additional, Willemsen, Gonneke, additional, Witt, Stephanie H., additional, Wu, Yang, additional, Xi, Hualin S., additional, Xu, Wei, additional, Yang, Jian, additional, Young, Allan H., additional, Zandi, Peter, additional, Zhang, Peng, additional, Zhang, Futao, additional, Zollner, Sebastian, additional, Adolfsson, Rolf, additional, Agartz, Ingrid, additional, Alda, Martin, additional, Arolt, Volker, additional, Backlund, Lena, additional, Baune, Bernhard T., additional, Bellivier, Frank, additional, Berger, Klaus, additional, Berrettini, Wade H., additional, Biernacka, Joanna M., additional, Blackwood, Douglas H.R., additional, Boehnke, Michael, additional, Boomsma, Dorret I., additional, Corvin, Aiden, additional, Craddock, Nicholas, additional, Daly, Mark J., additional, Dannlowski, Udo, additional, Domenici, Enrico, additional, Domschke, Katharina, additional, Esko, Tõnu, additional, Etain, Bruno, additional, Frye, Mark, additional, Fullerton, Janice M., additional, Gershon, Elliot S., additional, de Geus, E.J.C., additional, Gill, Michael, additional, Goes, Fernando, additional, Grabe, Hans J., additional, Grigoroiu-Serbanescu, Maria, additional, Hamilton, Steven P., additional, Hauser, Joanna, additional, Hayward, Caroline, additional, Heath, Andrew C., additional, Hougaard, David M., additional, Hultman, Christina M., additional, Jones, Ian, additional, Jones, Lisa A., additional, Kahn, René S., additional, Kendler, Kenneth S., additional, Kirov, George, additional, Kloiber, Stefan, additional, Landén, Mikael, additional, Leboyer, Marion, additional, Lewis, Glyn, additional, Li, Qingqin S., additional, Lissowska, Jolanta, additional, Lucae, Susanne, additional, Madden, Pamela A.F., additional, Magnusson, Patrik K., additional, Martin, Nicholas G., additional, Mayoral, Fermin, additional, McElroy, Susan L., additional, McIntosh, Andrew M., additional, McMahon, Francis J., additional, Melle, Ingrid, additional, Metspalu, Andres, additional, Mitchell, Philip B., additional, Morken, Gunnar, additional, Mors, Ole, additional, Mortensen, Preben Bo, additional, Müller-Myhsok, Bertram, additional, Myers, Richard M., additional, Neale, Benjamin M., additional, Nimgaonkar, Vishwajit, additional, Nordentoft, Merete, additional, Nöthen, Markus M., additional, O'Donovan, Michael C., additional, Oedegaard, Ketil J., additional, Owen, Michael J., additional, Paciga, Sara A., additional, Pato, Carlos, additional, Pato, Michele T., additional, Pedersen, Nancy L., additional, Penninx, Brenda W.J. H., additional, Perlis, Roy H., additional, Porteous, David J., additional, Posthuma, Danielle, additional, Potash, James B., additional, Preisig, Martin, additional, Ramos-Quiroga, Josep Antoni, additional, Ribasés, Marta, additional, Rietschel, Marcella, additional, Rouleau, Guy A., additional, Schaefer, Catherine, additional, Schalling, Martin, additional, Schofield, Peter R., additional, Schulze, Thomas G., additional, Serretti, Alessandro, additional, Smoller, Jordan W., additional, Stefansson, Hreinn, additional, Stefansson, Kari, additional, Stordal, Eystein, additional, Tiemeier, Henning, additional, Turecki, Gustavo, additional, Uher, Rudolf, additional, Vaaler, Arne E., additional, Vieta, Eduard, additional, Vincent, John B., additional, Völzke, Henry, additional, Weissman, Myrna M., additional, Werge, Thomas, additional, Andreassen, Ole A., additional, Børglum, Anders D., additional, Cichon, Sven, additional, Edenberg, Howard J., additional, Di Florio, Arianna, additional, Kelsoe, John, additional, Levinson, Douglas F., additional, Lewis, Cathryn M., additional, Nurnberger, John I., additional, Ophoff, Roel A., additional, Scott, Laura J., additional, Sklar, Pamela, additional, Sullivan, Patrick F., additional, and Wray, Naomi R., additional

Published
2020
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34. Property law.

Author

Friel, Christopher E., Fraser, Christine M., and Borges, Ryan M.

Subjects
Rhode Island
Published
1999

35. Municipal law.

Author

Roots, Roger I. and Fraser, Christine M.

Subjects
Government liability -- Surveys, Municipal government -- Surveys
Published
1999

40. Association of Polygenic Liabilities for Major Depression, Bipolar Disorder, and Schizophrenia With Risk for Depression in the Danish Population

Author

Musliner, Katherine L., Mortensen, Preben B., McGrath, John J., Suppli, Nis P., Hougaard, David M., Bybjerg-Grauholm, Jonas, Baekvad-Hansen, Marie, Andreassen, Ole, Pedersen, Carsten B., Pedersen, Marianne G., Mors, Ole, Nordentoft, Merete, Borglum, Anders D., Werge, Thomas, Agerbo, Esben, Stahl, Eli A., Breen, Gerome, Forstner, Andreas J., McQuillin, Andrew, Ripke, Stephan, Trubetskoy, Vassily, Mattheisen, Manuel, Wang, Yunpeng, Coleman, Jonathan R., I, Gaspar, Helena A., de Leeuw, Christiaan A., Steinberg, Stacy, Pavlides, Jennifer M. Whitehead, Trzaskowski, Maciej, Pers, Tune H., Holmans, Peter A., Abbott, Liam, Akil, Huda, Albani, Diego, Alliey-Rodriguez, Ney, Als, Thomas D., Anjorin, Adebayo, Antilla, Verneri, Awasthi, Swapnil, Badner, Judith A., Etzekvad-Hansen, Marie, Barchas, Jack D., Bass, Nicholas, Bauer, Michael, Belliveau, Richard, Bergen, Sarah E., Pedersen, Carsten Bocker, Boen, Erlend, Boks, Marco, Boocock, James, Budde, Monika, Bunney, William, Burmeister, Margit, Byerley, William, Casas, Miguel, Cerrato, Felecia, Cervantes, Pablo, Chambert, Kimberly, Chamey, Alexander W., Chen, Danfeng, Churchhouse, Claire, Clarke, Toni-Kim, Coryell, William, Craig, David W., Cruceanu, Cristiana, Curtis, David, Czerski, Piotr M., Dale, Anders M., de Jong, Simone, Degenhardt, Franziska, Del-Favero, Jurgen, DePaulo, J. Raymond, Djurovic, Srdjan, Dobbyn, Amanda L., Dumont, Ashley, Elvsashagen, Torbjorn, Escott-Price, Valentina, Fan, Chun Chieh, Fischer, Sascha B., Flickinger, Matthew, Foroud, Tatiana M., Forty, Liz, Frank, Josef, Fraser, Christine, Freimer, Nelson B., Frisen, Louise, Gade, Katrin, Gage, Diane, Garnham, Julie, Giambartobmei, Claudia, Pedersen, Marianne Giortz, Goldstein, Jaqueline, Gordon, Scott D., Gordon-Smith, Katherine, Green, Elaine K., Green, Melissa J., Greenwood, Tiffany A., Grove, Jakob, Guan, Weihua, Parra, Jose Guzman, Hamshere, Marian L., Hautzinger, Martin, Heilbronner, Urs, Herms, Stefan, Hipolito, Maria, Hoffmann, Per, Holland, Dominic, Huckins, Laura, Jamain, Stephan, Johnson, Jessica S., Jureus, Anders, Kandaswamy, Radhika, Karlsson, Robert, Kennedy, James L., Kittel-Schneider, Sarah, Knott, Sarah, V, Knowles, James A., Kogevinas, Manolis, Koller, Anna C., Kupka, Ralph, Lavebratt, Catharina, Lawrence, Jacob, Lawson, William B., Leber, Markus, Lee, Phil H., Levy, Shawn E., Li, Jun Z., Liu, Chunyu, Lucae, Susanne, Maaser, Anna, MacIntyre, Donald J., Mahon, Pamela B., Maier, Wolfgang, Martinsson, Lina, McCarroll, Steve, McGuffin, Peter, McInnis, Melvin G., McKay, James D., Medeiros, Helena, Medland, Sarah E., Meng, Fan, Milani, Lili, Montgomery, Grant W., Morris, Derek W., Muehleisen, Thomas W., Mullins, Niamh, Nguyen, Hoang, Nievergelt, Caroline M., Adolfsson, Annelie Nordin, Nwulia, Evaristus A., O'Donovan, Claire, Loohuis, Loes M. Olde, Ori, Anil P. S., Oruc, Lilijana, Osby, Urban, Perlis, Roy H., Perry, Amy, Pfennig, Andrea, Potash, James B., Purcell, Shaun M., Regeer, Eline J., Reif, Andreas, Reinbold, Celine S., Rice, John P., Rivas, Fabio, Rivera, Margarita, Roussos, Panos, Ruderfer, Douglas M., Ryu, Euijung, Sanchez-Mora, Cristina, Schatzberg, Alan F., Scheftner, William A., Schork, Nicholas J., Weickert, Cynthia Shannon, Shehktman, Tatyana, Shilling, Paul D., Sigurdsson, Engilbert, Slaney, Claire, Smeland, Olav B., Sobell, Janet L., Hansen, Christine Soholm, Spijker, Anne T., St Clair, David, Steffens, Michael, Strauss, John S., Streit, Fabian, Strohmaier, Jana, Szelinger, Szabolcs, Thompson, Robert C., Thorgeirsson, Thorgeir E., Treutlein, Jens, Vedder, Helmut, Wang, Weiqing, Watson, Stanley J., Weickert, Thomas W., Witt, Stephanie H., Xi, Simon, Xu, Wei, Young, Allan H., Zandi, Peter, Zhang, Peng, Zollner, Sebastian, Agartz, Ingrid, Aida, Martin, Backlund, Lena, Baune, Bernhard T., Bellivier, Frank, Berrettini, Wade H., Biemacka, Joanna M., Blackwood, Douglas H. R., Boehnke, Michael, Berglum, Anders D., Corvin, Aiden, Craddock, Nicholas, Daly, Mark J., Dannlowski, Udo, Esko, Tonu, Etain, Bruno, Frye, Mark, Fullerton, Janice M., Gershon, Elliot S., Goes, Fernando, Grigoroiu-Serbanescu, Maria, Hauser, Joanna, Hultman, Christina M., Jones, Ian, Jones, Lisa A., Kahn, Rene S., Kirov, George, Landen, Mikael, Leboyer, Marion, Lewis, Cathryn M., Li, Qingqin S., Lissowska, Jolanta, Martin, Nicholas G., Mayoral, Fermin, McElroy, Susan L., McIntosh, Andrew M., McMahon, Francis J., Melle, Ingrid, Metspalu, Andres, Mitchell, Philip B., Morken, Gunnar, Mortensen, Preben Bo, Mueller-Myhsok, Bertram, Myers, Richard M., Neale, Benjamin M., Nimgaonkar, Vishwajit, Noethen, Markus M., O'Donovan, Michael C., Oedegaard, Ketil J., Owen, Michael, Paciga, Sara A., Pato, Carlos, Pato, Michele T., Posthuma, Danielle, Ramos-Quiroga, Josep Antoni, Ribases, Marta, Rietschel, Marcella, Rouleau, Guy A., Schalling, Martin, Schofield, Peter R., Schulze, Thomas G., Serretti, Alessandro, Smoller, Jordan W., Stefansson, Hreinn, Stefansson, Kari, Stordal, Eystein, Sullivan, Patrick F., Turecki, Gustavo, Vaaler, Arne E., Ieta, Eduard, V, Vincent, John B., Nurnberger, John, I, Wray, Naomi R., Di Florio, Arianna, Edenberg, Howard J., Cichon, Sven, Ophoff, Roel A., Scott, Laura J., Andreassen, Ole A., Kelsoe, John, Sklar, Pamela, and Psychiat Genomics Consortium

Subjects
Adult, Male, medicine.medical_specialty, Multifactorial Inheritance, Bipolar Disorder, Adolescent, Denmark, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Risk Factors, medicine, Journal Article, Humans, Genetic Predisposition to Disease, Bipolar disorder, Young adult, Association (psychology), Psychiatry, Child, Depression (differential diagnoses), Proportional Hazards Models, Depressive Disorder, Major, Proportional hazards model, business.industry, Depression, Case-control study, Age Factors, medicine.disease, 030227 psychiatry, Psychiatry and Mental health, Schizophrenia, Case-Control Studies, Linear Models, Major depressive disorder, Female, Human medicine, business, 030217 neurology & neurosurgery
Abstract

Importance: Although the usefulness of polygenic risk scores as a measure of genetic liability for major depression (MD) has been established, their association with depression in the general population remains relatively unexplored.Objective: To evaluate whether polygenic risk scores for MD, bipolar disorder (BD), and schizophrenia (SZ) are associated with depression in the general population and explore whether these polygenic liabilities are associated with heterogeneity in terms of age at onset and severity at the initial depression diagnosis.Design, Setting, and Participants: Participants were drawn from the Danish iPSYCH2012 case-cohort study, a representative sample drawn from the population of Denmark born between May 1, 1981, and December 31, 2005. The hazard of depression was estimated using Cox regressions modified to accommodate the case-cohort design. Case-only analyses were conducted using linear and multinomial regressions. The data analysis was conducted from February 2017 to June 2018.Exposures: Polygenic risk scores for MD, BD, and SZ trained using the most recent genome-wide association study results from the Psychiatric Genomics Consortium.Main Outcomes and Measures: The main outcome was first depressive episode (International Statistical Classification of Diseases and Related Health Problems, Tenth Revision [ICD-10] code F32) treated in hospital-based psychiatric care. Severity at the initial diagnosis was measured using the ICD-10 code severity specifications (mild, moderate, severe without psychosis, and severe with psychosis) and treatment setting (inpatient, outpatient, and emergency).Results: Of 34 573 participants aged 10 to 31 years at censoring, 68% of those with depression were female compared with 48.9% of participants without depression. Each SD increase in polygenic liability for MD, BD, and SZ was associated with 30% (hazard ratio [HR], 1.30; 95% CI, 1.27-1.33), 5% (HR, 1.05; 95% CI, 1.02-1.07), and 12% (HR, 1.12; 95% CI, 1.09-1.15) increases in the hazard of depression, respectively. Among cases, a higher polygenic liability for BD was associated with earlier depression onset (β = -.07; SE = .02; P = .002).Conclusions and Relevance: Polygenic liability for MD is associated with first depression in the general population, which supports the idea that these scores tap into an underlying liability for developing the disorder. The fact that polygenic risk for BD and polygenic risk for SZ also were associated with depression is consistent with prior evidence that these disorders share some common genetic overlap. Variations in polygenic liability may contribute slightly to heterogeneity in clinical presentation, but these associations appear minimal.

Published
2019

41. Genome-wide association study identifies 30 loci associated with bipolar disorder

Author

Stahl, Eli A., Breen, Gerome, Forstner, Andreas J., McQuillin, Andrew, Ripke, Stephan, Trubetskoy, Vassily, Mattheisen, Manuel, Wang, Yunpeng, Coleman, Jonathan R.I., Gaspar, Héléna A., de Leeuw, Christiaan A., Steinberg, Stacy, Pavlides, Jennifer M. Whitehead, Trzaskowski, Maciej, Byrne, Enda M., Pers, Tune H., Holmans, Peter A., Richards, Alexander L., Abbott, Liam, Agerbo, Esben, Akil, Huda, Albani, Diego, Alliey-Rodriguez, Ney, Als, Thomas D., Anjorin, Adebayo, Antilla, Verneri, Awasthi, Swapnil, Badner, Judith A., Bækvad-Hansen, Marie, Barchas, Jack D., Bass, Nicholas, Bauer, Michael, Belliveau, Richard, Bergen, Sarah E., Pedersen, Carsten Bøcker, Bøen, Erlend, Boks, Marco P., Boocock, James, Budde, Monika, Bunney, William, Burmeister, Margit, Bybjerg-Grauholm, Jonas, Byerley, William, Casas, Miquel, Cerrato, Felecia, Cervantes, Pablo, Chambert, Kimberly, Charney, Alxander W., Chen, Danfeng, Churchhouse, Claire, Clarke, Toni-Kim, Coryell, William, Craig, David W., Cruceanu, Cristiana, Curtis, David, Czerski, Piotr M., Dale, Anders, de Jong, Simone, Degenhardt, Franziska, Del-Favero, Jurgen, Depaulo, J. Raymond, Djurovic, Srdjan, Dobbyn, Amanda L., Dumont, Ashley, Elvsåshagen, Torbjørn, Escott-Price, Valentina, Fan, Chun Chieh, Fischer, Sascha B., Flickinger, Matthew, Foroud, Tatiana M., Forty, Liz, Frank, Josef, Fraser, Christine, Freimer, Nelson B., Frisén, Louise, Gade, Katrin, Gage, Diane, Garnham, Julie, Giambartolomei, Claudia, Pedersen, Marianne Giørtz, Goldstein, Jaqueline, Gordon, Scott D., Gordon-Smith, Katherine, Green, Elaine K., Green, Melissa J., Greenwood, Tifany A., Grove, Jakob, Guan, Weihua, Guzman-Parra, José, Hamshere, Marian L., Hautzinger, Martin, Heilbronner, Urs, Herms, Stefan, Hipolito, Maria, Hoffmann, Per, Holland, Dominic, Huckins, Laura, Jamain, Stéphane, Johnson, Jessica S., Juréus, Anders, Kandaswamy, Radhika, Karlsson, Robert, Kennedy, James L., Kittel-Schneider, Sarah, Knowles, James A., Kogevinas, Manolis, Koller, Anna C., Kupka, Ralph, Lavebratt, Catharina, Lawrence, Jacob, Lawson, William B., Leber, Markus, Lee, Phil H., Levy, Shawn E., Li, Jun Z., Liu, Chunyu, Lucae, Susanne, Maaser, Anna, MacIntyre, Donald J., Mahon, Pamela B., Maier, Wolfgang, Martinsson, Lina, McCarroll, Steve, McGuffin, Peter, McInnis, Melvin G., McKay, James D., Medeiros, Helena, Medland, Sarah E., Meng, Fan, Milani, Lili, Montgomery, Grant W., Morris, Derek W., Mühleisen, Thomas W., Mullins, Niamh, Nguyen, Hoang, Nievergelt, Caroline M., Adolfsson, Annelie Nordin, Nwulia, Evaristus A., O'Donovan, Claire, Loohuis, Loes M. Olde, Ori, Anil P.S., Oruc, Lilijana, Ösby, Urban, Perlis, Roy H., Perry, Amy, Pfennig, Andrea, Potash, James B., Purcell, Shaun M., Regeer, Eline J., Reif, Andreas, Reinbold, Céline S., Rice, John P., Rivas, Fabio, Rivera, Margarita, Roussos, Panos, Ruderfer, Douglas M., Ryu, Euijung, Sánchez-Mora, Cristina, Schatzberg, Alan F., Scheftner, William A., Schork, Nicholas J., Shannon Weickert, Cynthia, Shehktman, Tatyana, Shilling, Paul D., Sigurdsson, Engilbert, Slaney, Claire, Smeland, Olav Bjerkehagen, Sobell, Janet L., Søholm Hansen, Christine, Spijker, Anne T., St Clair, David, Steffens, Michael, Strauss, John S., Streit, Fabian, Strohmaier, Jana, Szelinger, Szabolcs, Thompson, Robert C., Thorgeirsson, Thorgeir E, Treutlein, Jens, Vedder, Helmut, Wang, Weiqing, Watson, Stanley J., Weickert, Thomas W., Witt, Stephanie H., Xi, Simon, Xu, Wei, Young, Allan H., Zandi, Peter, Zhang, Peng, Zöllner, Sebastian, Adolfsson, Rolf, Agartz, Ingrid, Alda, Martin, Backlund, Lena, Baune, Bernhard T., Bellivier, Frank, Berrettini, Wade H., Biernacka, Joanna M., Blackwood, Douglas H.R., Boehnke, Michael, Børglum, Anders D., Corvin, Aiden, Craddock, Nicholas, Daly, Mark J., Dannlowski, Udo, Esko, Tõnu, Etain, Bruno, Frye, Mark, Fullerton, Janice M., Gershon, Elliot S., Gill, Michael, Goes, Fernando, Grigoroiu-Serbanescu, Maria, Hauser, Joanna, Hougaard, David M., Hultman, Christina M., Jones, Ian, Jones, Lisa A., Kahn, René S., Kirov, George, Landén, Mikael, Leboyer, Marion, Lewis, Cathryn M., Li, Qingqin S., Lissowska, Jolanta, Martin, Nicholas G., Mayoral, Fermin, McElroy, Susan L., McIntosh, Andrew M., McMahon, Francis J., Melle, Ingrid, Metspalu, Andres, Mitchell, Philip B., Morken, Gunnar, Mors, Ole, Mortensen, Preben Bo, Müller-Myhsok, Bertram, Myers, Richard M., Neale, Benjamin M., Nimgaonkar, Vishwajit, Nordentoft, Merete, Nöthen, Markus M., O'Donovan, Michael C, Ødegaard, Ketil Joachim, Owen, Michael J., Paciga, Sara A., Pato, Carlos, Pato, Michele T., Posthuma, Danielle, Ramos-Quiroga, Josep Antoni, Ribasés, Marta, Rietschel, Marcella, Rouleau, Guy A., Schalling, Martin, Schofield, Peter R., Schulze, Thomas G., Serretti, Alessandro, Smoller, Jordan W., Stefansson, Hreinn, Stefansson, Kari, Stordal, Eystein, Sullivan, Patrick F., Turecki, Gustavo, Vaaler, Arne, Vieta, Eduard, Vincent, John B., Werge, Thomas, Nurnberger, John I., Wray, Naomi R., Di Florio, Arianna, Edenberg, Howard J., Cichon, Sven, Ophoff, Roel A., Scott, Laura J., Andreassen, Ole Andreas, Kelsoe, John, and Sklar, Pamela

Abstract

Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide association study (GWAS) including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 822 variants with P

Published
2019

42. Agitated depression in bipolar disorder

Author

Serra, Francesca, primary, Gordon‐Smith, Katherine, additional, Perry, Amy, additional, Fraser, Christine, additional, Di Florio, Arianna, additional, Craddock, Nick, additional, Jones, Ian, additional, and Jones, Lisa, additional

Published
2019
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43. Normal Routine Spirometry Can Mask Clinical and Physiologic Detection of COPD and Emphysema in Symptomatic Smokers

Author

Gelb, Arthur F., primary, Yamamoto, Alfred, additional, Zamel, Noe, additional, Hogg, James C., additional, Tran, Diem N.T., additional, Moridzadeh, Roxanna M., additional, Fraser, Christine, additional, Rideout, Richard F., additional, Post, Amanda, additional, Schein, Mark, additional, Verbeken, Eric K., additional, Decramer, Marc, additional, Glassy, Eric F., additional, and Nadel, Jay A., additional

Published
2019
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44. Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder

Author

de Jong, Simone, Abdalla Diniz, Mateus Jose, Saloma, Andiara, Gadelha, Ary, Santoro, Marcos L., Ota, Vanessa K., Noto, Cristiano, Curtis, Charlesg, Newhouse, Stephen J., Patel, Hamel, Hall, Lynsey S., O'Reilly, Paul F., Belangero, Sintia, I, Bressan, Rodrigo A., Breen, Gerome, Wray, Naomi R., Ripke, Stephan, Mattheisen, Manuel, Trzaskowski, Maciej, Byrne, Enda M., Abdellaoui, Abdel, Adams, Mark J., Agerbo, Esben, Air, Tracy M., Andlauer, Till F. M., Bacanu, Silviu-Alin, Baekvad-Hansen, Marie, Beekman, Aartjan T. F., Bigdeli, Tim B., Binder, Elisabeth B., Blackwood, Douglas H. R., Bryois, Julien, Buttenschon, Henriette N., Bybjerg-Grauholm, Jonas, Cai, Na, Castelao, Enrique, Christensen, Jane Hvarregaard, Clarke, Toni-Kim, Coleman, Jonathan R., I, Colodro-Conde, Lucia, Couvy-Duchesne, Baptiste, Craddock, Nick, Crawford, Gregory E., Davies, Gail, Deary, Ian J., Degenhardt, Franziska, Derks, Eske M., Direk, Nese, Dolan, Conor, V, Dunn, Erin C., Eley, Thalia C., Escott-Price, Valentina, Kiadeh, Farnush Farhadi Hassan, Finucane, Hilary K., Forstner, Andreas J., Frank, Josef, Gaspar, Helena A., Gill, Michael, Goes, Fernando S., Gordon, Scott D., Grove, Jakob, Hansen, Christine Soholm, Hansen, Thomas F., Herms, Stefan, Hickie, Ian B., Hoffmann, Per, Homuth, Georg, Horn, Carsten, Hottenga, Jouke-Jan, Hougaard, David M., Ising, Marcus, Jansen, Rick, Jones, Ian, Jones, Lisa A., Jorgenson, Eric, Knowles, James A., Kohane, Isaac S., Kraft, Julia, Kretzschmar, Warren W., Krogh, Jesper, Kutalik, Zoltan, Li, Yihan, Lind, Penelope A., MacIntyre, Donald J., MacKinnon, Dean F., Maier, Robert M., Maier, Wolfgang, Marchini, Jonathan, Mbarek, Hamdi, Mcgrath, Patrick, Mcguffin, Peter, Medland, Sarah E., Mehta, Divya, Middeldorp, Christel M., Mihailov, Evelin, Milaneschi, Yuri, Milani, Lili, Mondimore, Francis M., Montgomery, Grant W., Mostafavi, Sara, Mullins, Niamh, Nauck, Matthias, Ng, Bernard, Nivard, Michel G., Nyholt, Dale R., Oskarsson, Hogni, Owen, Michael J., Painter, Jodie N., Pedersen, Carsten Bocker, Pedersen, Marianne Giortz, Peterson, Roseann E., Pettersson, Erik, Peyrot, Wouter J., Pistis, Giorgio, Posthuma, Danielle, Quiroz, Jorge A., Qvist, Per, Rice, John P., Riley, Brien P., Rivera, Margarita, Mirza, Saira Saeed, Schoevers, Robert, Schulte, Eva C., Shen, Ling, Shyn, Stanley, I, Sigurdsson, Engilbert, Sinnamon, Grant C. B., Smit, Johannes H., Smith, Daniel J., Stefansson, Hreinn, Steinberg, Stacy, Streit, Fabian, Strohmaier, Jana, Tansey, Katherine E., Teismann, Henning, Teumer, Alexander, Thompson, Wesley, Thomson, Pippa A., Thorgeirsson, Thorgeir E., Traylor, Matthew, Treutlein, Jens, Trubetskoy, Vassily, Uitterlinden, Andre G., Umbricht, Daniel, Van der Auwera, Sandra, van Hemert, Albert M., Viktorin, Alexander, Visscher, Peter M., Wang, Yunpeng, Webb, Bradley T., Weinsheimer, Shantel Marie, Wellmann, Juergen, Willemsen, Gonneke, Witt, Stephanie H., Wu, Yang, Xi, Hualin S., Yang, Jian, Zhang, Futao, Arolt, Volker, Baune, Bernhard T., Berger, Klaus, Boomsma, Dorret, I, Cichon, Sven, Dannlowski, Udo, de Geus, E. J. C., DePaulo, J. Raymond, Domenici, Enrico, Domschke, Katharina, Esko, Tonu, Grabe, Hans J., Hamilton, Steven P., Hayward, Caroline, Heath, Andrew C., Kendler, Kenneth S., Kloiber, Stefan, Lewis, Glyn, Li, Qingqin S., Lucae, Susanne, Madden, Pamela A. F., Magnusson, Patrik K., Martin, Nicholas G., McIntosh, Andrew M., Metspalu, Andres, Mors, Ole, Mortensen, Preben Bo, Mueller-Myhsok, Bertram, Nordentoft, Merete, Noethen, Markus M., O'Donovan, Michael C., Paciga, Sara A., Pedersen, Nancy L., Penninx, Brenda W. J. H., Perlis, Roy H., Porteous, David J., Potash, James B., Preisig, Martin, Rietschel, Marcella, Schaefer, Catherine, Schulze, Thomas G., Smoller, Jordan W., Stefansson, Kari, Tiemeier, Henning, Uher, Rudolf, Voelzke, Henry, Weissman, Myrna M., Werge, Thomas, Lewis, Cathryn M., Levinson, Douglas F., Borglum, Anders D., Sullivan, Patrick F., Meier, Sandra, Strauss, John, Xu, Wei, Vincent, John B., Matthews, Keith, Ferreira, Manuel, O'Dushlaine, Colm, Purcell, Shaun, Raychaudhuri, Soumya, Ruderfer, Douglas M., Sklar, Pamela, Scott, Laura J., Flickinger, Matthew, Burmeister, Margit, Li, Jun, Guan, Weihua, Absher, Devin, Thompson, Robert C., Meng, Fan Guo, Schatzberg, Alan F., Bunney, William E., Barchas, Jack D., Watson, Stanley J., Myers, Richard M., Akil, Huda, Boehnke, Michael, Chambert, Kimberly, Moran, Jennifer, Scolnick, Edward, Djurovic, Srdjan, Melle, Ingrid, Morken, Gunnar, Corvin, Aiden, Anjorin, Adebayo, Kandaswamy, Radhika, Lawrence, Jacob, McLean, Alan W., Pickard, Benjamin S., Bergen, Sarah E., Nimgaonkar, Vishwajit, Landen, Mikael, Schalling, Martin, Osby, Urban, Backlund, Lena, Frisen, Louise, Langstrom, Niklas, Stahl, Eli, Dobbyn, Amanda, Jamain, Stephane, Etain, Bruno, Bellivier, Frank, Leber, Markus, Maaser, Anna, Fischer, Sascha B., Reinbold, Celine S., Kittel-Schneider, Sarah, Fullerton, Janice M., Oruc, Lilijana, Para, Jose G., Mayoral, Fermin, Rivas, Fabio, Czerski, Piotr M., Kammerer-Ciernioch, Jutta, Vedder, Helmut, Borrmann-Hassenbach, Margitta, Pfennig, Andrea, Brennan, Paul, McKay, James D., Kogevinas, Manolis, Schwarz, Markus, Schofield, Peter R., Muehleisen, Thomas W., Schumacher, Johannes, Bauer, Michael, Wright, Adam, Mitchell, Philip B., Hautzinger, Martin, Kelsoe, John R., Greenwood, Tiffany A., Nievergelt, Caroline M., Shilling, Paul D., Smith, Erin N., Bloss, Cinnamon S., Edenberg, Howard J., Koller, Daniel L., Gershon, Elliot S., Liu, Chunyu, Badner, Judith A., Scheftner, William A., Lawson, William B., Nwulia, Evaristus A., Hipolito, Maria, Coryell, William, Rice, John, Byerley, William, McMahon, Francis J., Lohoff, Falk W., Zandi, Peter P., Mahon, Pamela B., McInnis, Melvin G., Zollner, Sebastian, Zhang, Peng, Szelinger, Szabolcs, St Clair, David, Caesar, Sian, Gordon-Smith, Katherine, Fraser, Christine, Green, Elaine K., Grozeva, Detelina, Hamshere, Marian L., Kirov, George, Nikolov, Ivan, Collier, David A., Elkin, Amanda, Williamson, Richard, Young, Allan H., Ferrier, I. Nicol, Milanova, Vihra, Alda, Martin, Cervantes, Pablo, Cruceanu, Cristiana, Rouleau, Guy A., Turecki, Gustavo, Paciga, Sara, Winslow, Ashley R., Grigoroiu-Serbanescu, Maria, Ophoff, Roel, Adolfsson, Rolf, Nordin Adolfsson, Annelie, Del-Favero, Jurgen, Pato, Carlos, Biernacka, Joanna M., Frye, Mark A., Morris, Derek, Schork, Nicholas J., Reif, Andreas, Lissowska, Jolanta, Hauser, Joanna, Szeszenia-Dabrowska, Neonila, McGhee, Kevin, Quinn, Emma, Moskvina, Valentina, Holmans, Peter A., Farmer, Anne, Kennedy, James L., Andreassen, Ole A., Mattingsdal, Morten, Bass, Nicholas J., Gurling, Hugh, McQuillin, Andrew, Breuer, Rene, Hultman, Christina, Lichtenstein, Paul, Huckins, Laura M., Leboyer, Marion, Lathrop, Mark, Nurnberger, John, Steffens, Michael, Foroud, Tatiana M., Berrettini, Wade H., Craig, David W., Shi, Jianxin, de Jong, Simone, Abdalla Diniz, Mateus Jose, Saloma, Andiara, Gadelha, Ary, Santoro, Marcos L., Ota, Vanessa K., Noto, Cristiano, Curtis, Charlesg, Newhouse, Stephen J., Patel, Hamel, Hall, Lynsey S., O'Reilly, Paul F., Belangero, Sintia, I, Bressan, Rodrigo A., Breen, Gerome, Wray, Naomi R., Ripke, Stephan, Mattheisen, Manuel, Trzaskowski, Maciej, Byrne, Enda M., Abdellaoui, Abdel, Adams, Mark J., Agerbo, Esben, Air, Tracy M., Andlauer, Till F. M., Bacanu, Silviu-Alin, Baekvad-Hansen, Marie, Beekman, Aartjan T. F., Bigdeli, Tim B., Binder, Elisabeth B., Blackwood, Douglas H. R., Bryois, Julien, Buttenschon, Henriette N., Bybjerg-Grauholm, Jonas, Cai, Na, Castelao, Enrique, Christensen, Jane Hvarregaard, Clarke, Toni-Kim, Coleman, Jonathan R., I, Colodro-Conde, Lucia, Couvy-Duchesne, Baptiste, Craddock, Nick, Crawford, Gregory E., Davies, Gail, Deary, Ian J., Degenhardt, Franziska, Derks, Eske M., Direk, Nese, Dolan, Conor, V, Dunn, Erin C., Eley, Thalia C., Escott-Price, Valentina, Kiadeh, Farnush Farhadi Hassan, Finucane, Hilary K., Forstner, Andreas J., Frank, Josef, Gaspar, Helena A., Gill, Michael, Goes, Fernando S., Gordon, Scott D., Grove, Jakob, Hansen, Christine Soholm, Hansen, Thomas F., Herms, Stefan, Hickie, Ian B., Hoffmann, Per, Homuth, Georg, Horn, Carsten, Hottenga, Jouke-Jan, Hougaard, David M., Ising, Marcus, Jansen, Rick, Jones, Ian, Jones, Lisa A., Jorgenson, Eric, Knowles, James A., Kohane, Isaac S., Kraft, Julia, Kretzschmar, Warren W., Krogh, Jesper, Kutalik, Zoltan, Li, Yihan, Lind, Penelope A., MacIntyre, Donald J., MacKinnon, Dean F., Maier, Robert M., Maier, Wolfgang, Marchini, Jonathan, Mbarek, Hamdi, Mcgrath, Patrick, Mcguffin, Peter, Medland, Sarah E., Mehta, Divya, Middeldorp, Christel M., Mihailov, Evelin, Milaneschi, Yuri, Milani, Lili, Mondimore, Francis M., Montgomery, Grant W., Mostafavi, Sara, Mullins, Niamh, Nauck, Matthias, Ng, Bernard, Nivard, Michel G., Nyholt, Dale R., Oskarsson, Hogni, Owen, Michael J., Painter, Jodie N., Pedersen, Carsten Bocker, Pedersen, Marianne Giortz, Peterson, Roseann E., Pettersson, Erik, Peyrot, Wouter J., Pistis, Giorgio, Posthuma, Danielle, Quiroz, Jorge A., Qvist, Per, Rice, John P., Riley, Brien P., Rivera, Margarita, Mirza, Saira Saeed, Schoevers, Robert, Schulte, Eva C., Shen, Ling, Shyn, Stanley, I, Sigurdsson, Engilbert, Sinnamon, Grant C. B., Smit, Johannes H., Smith, Daniel J., Stefansson, Hreinn, Steinberg, Stacy, Streit, Fabian, Strohmaier, Jana, Tansey, Katherine E., Teismann, Henning, Teumer, Alexander, Thompson, Wesley, Thomson, Pippa A., Thorgeirsson, Thorgeir E., Traylor, Matthew, Treutlein, Jens, Trubetskoy, Vassily, Uitterlinden, Andre G., Umbricht, Daniel, Van der Auwera, Sandra, van Hemert, Albert M., Viktorin, Alexander, Visscher, Peter M., Wang, Yunpeng, Webb, Bradley T., Weinsheimer, Shantel Marie, Wellmann, Juergen, Willemsen, Gonneke, Witt, Stephanie H., Wu, Yang, Xi, Hualin S., Yang, Jian, Zhang, Futao, Arolt, Volker, Baune, Bernhard T., Berger, Klaus, Boomsma, Dorret, I, Cichon, Sven, Dannlowski, Udo, de Geus, E. J. C., DePaulo, J. Raymond, Domenici, Enrico, Domschke, Katharina, Esko, Tonu, Grabe, Hans J., Hamilton, Steven P., Hayward, Caroline, Heath, Andrew C., Kendler, Kenneth S., Kloiber, Stefan, Lewis, Glyn, Li, Qingqin S., Lucae, Susanne, Madden, Pamela A. F., Magnusson, Patrik K., Martin, Nicholas G., McIntosh, Andrew M., Metspalu, Andres, Mors, Ole, Mortensen, Preben Bo, Mueller-Myhsok, Bertram, Nordentoft, Merete, Noethen, Markus M., O'Donovan, Michael C., Paciga, Sara A., Pedersen, Nancy L., Penninx, Brenda W. J. H., Perlis, Roy H., Porteous, David J., Potash, James B., Preisig, Martin, Rietschel, Marcella, Schaefer, Catherine, Schulze, Thomas G., Smoller, Jordan W., Stefansson, Kari, Tiemeier, Henning, Uher, Rudolf, Voelzke, Henry, Weissman, Myrna M., Werge, Thomas, Lewis, Cathryn M., Levinson, Douglas F., Borglum, Anders D., Sullivan, Patrick F., Meier, Sandra, Strauss, John, Xu, Wei, Vincent, John B., Matthews, Keith, Ferreira, Manuel, O'Dushlaine, Colm, Purcell, Shaun, Raychaudhuri, Soumya, Ruderfer, Douglas M., Sklar, Pamela, Scott, Laura J., Flickinger, Matthew, Burmeister, Margit, Li, Jun, Guan, Weihua, Absher, Devin, Thompson, Robert C., Meng, Fan Guo, Schatzberg, Alan F., Bunney, William E., Barchas, Jack D., Watson, Stanley J., Myers, Richard M., Akil, Huda, Boehnke, Michael, Chambert, Kimberly, Moran, Jennifer, Scolnick, Edward, Djurovic, Srdjan, Melle, Ingrid, Morken, Gunnar, Corvin, Aiden, Anjorin, Adebayo, Kandaswamy, Radhika, Lawrence, Jacob, McLean, Alan W., Pickard, Benjamin S., Bergen, Sarah E., Nimgaonkar, Vishwajit, Landen, Mikael, Schalling, Martin, Osby, Urban, Backlund, Lena, Frisen, Louise, Langstrom, Niklas, Stahl, Eli, Dobbyn, Amanda, Jamain, Stephane, Etain, Bruno, Bellivier, Frank, Leber, Markus, Maaser, Anna, Fischer, Sascha B., Reinbold, Celine S., Kittel-Schneider, Sarah, Fullerton, Janice M., Oruc, Lilijana, Para, Jose G., Mayoral, Fermin, Rivas, Fabio, Czerski, Piotr M., Kammerer-Ciernioch, Jutta, Vedder, Helmut, Borrmann-Hassenbach, Margitta, Pfennig, Andrea, Brennan, Paul, McKay, James D., Kogevinas, Manolis, Schwarz, Markus, Schofield, Peter R., Muehleisen, Thomas W., Schumacher, Johannes, Bauer, Michael, Wright, Adam, Mitchell, Philip B., Hautzinger, Martin, Kelsoe, John R., Greenwood, Tiffany A., Nievergelt, Caroline M., Shilling, Paul D., Smith, Erin N., Bloss, Cinnamon S., Edenberg, Howard J., Koller, Daniel L., Gershon, Elliot S., Liu, Chunyu, Badner, Judith A., Scheftner, William A., Lawson, William B., Nwulia, Evaristus A., Hipolito, Maria, Coryell, William, Rice, John, Byerley, William, McMahon, Francis J., Lohoff, Falk W., Zandi, Peter P., Mahon, Pamela B., McInnis, Melvin G., Zollner, Sebastian, Zhang, Peng, Szelinger, Szabolcs, St Clair, David, Caesar, Sian, Gordon-Smith, Katherine, Fraser, Christine, Green, Elaine K., Grozeva, Detelina, Hamshere, Marian L., Kirov, George, Nikolov, Ivan, Collier, David A., Elkin, Amanda, Williamson, Richard, Young, Allan H., Ferrier, I. Nicol, Milanova, Vihra, Alda, Martin, Cervantes, Pablo, Cruceanu, Cristiana, Rouleau, Guy A., Turecki, Gustavo, Paciga, Sara, Winslow, Ashley R., Grigoroiu-Serbanescu, Maria, Ophoff, Roel, Adolfsson, Rolf, Nordin Adolfsson, Annelie, Del-Favero, Jurgen, Pato, Carlos, Biernacka, Joanna M., Frye, Mark A., Morris, Derek, Schork, Nicholas J., Reif, Andreas, Lissowska, Jolanta, Hauser, Joanna, Szeszenia-Dabrowska, Neonila, McGhee, Kevin, Quinn, Emma, Moskvina, Valentina, Holmans, Peter A., Farmer, Anne, Kennedy, James L., Andreassen, Ole A., Mattingsdal, Morten, Bass, Nicholas J., Gurling, Hugh, McQuillin, Andrew, Breuer, Rene, Hultman, Christina, Lichtenstein, Paul, Huckins, Laura M., Leboyer, Marion, Lathrop, Mark, Nurnberger, John, Steffens, Michael, Foroud, Tatiana M., Berrettini, Wade H., Craig, David W., and Shi, Jianxin

Abstract

Psychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the application of polygenic risk scores to also highlight patterns of common genetic risk. We analyze polygenic risk scores for psychiatric disorders in a large pedigree (n ~ 260) in which 30% of family members suffer from major depressive disorder or bipolar disorder. Studying patterns of assortative mating and anticipation, it appears increased polygenic risk is contributed by affected individuals who married into the family, resulting in an increasing genetic risk over generations. This may explain the observation of anticipation in mood disorders, whereby onset is earlier and the severity increases over the generations of a family. Joint analyses of rare and common variation may be a powerful way to understand the familial genetics of psychiatric disorders.

Published
2018
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45. Improving genetic prediction by leveraging genetic correlations among human diseases and traits

Author

Maier, Robert M., Zhu, Zhihong, Lee, Sang Hong, Trzaskowski, Maciej, Ruderfer, Douglas M., Stahl, Eli A., Ripke, Stephan, Wray, Naomi R., Yang, Jian, Visscher, Peter M., Robinson, Matthew R., Forstner, Andreas J., Mcquillin, Andrew, Trubetskoy, Vassily, Wang, Weiqing, Wang, Yunpeng, Coleman, Jonathan R.I., Gaspar, Héléna A., De Leeuw, Christiaan A., Whitehead Pavlides, Jennifer M., Olde Loohuis, Loes M., Pers, Tune H., Lee, Phil H., Charney, Alexander W., Dobbyn, Amanda L., Huckins, Laura, Boocock, James, Giambartolomei, Claudia, Roussos, Panos, Mullins, Niamh, Awasthi, Swapnil, Agerbo, Esben, Als, Thomas D., Pedersen, Carsten Bøcker, Grove, Jakob, Kupka, Ralph, Regeer, Eline J., Anjorin, Adebayo, Casas, Miquel, Mahon, Pamela B., Allardyce, Judith, Escott-Price, Valentina, Forty, Liz, Fraser, Christine, Kogevinas, Manolis, Frank, Josef, Streit, Fabian, Strohmaier, Jana, Treutlein, Jens, Witt, Stephanie H., Kennedy, James L., Strauss, John S., Garnham, Julie, O'donovan, Claire, Slaney, Claire, Steinberg, Stacy, Thorgeirsson, Thorgeir E., Hautzinger, Martin, Steffens, Michael, Perlis, Roy H., Sánchez-Mora, Cristina, Hipolito, Maria, Lawson, William B., Nwulia, Evaristus A., Levy, Shawn E., Foroud, Tatiana M., Jamain, Stéphane, Young, Allan H., Mckay, James D., Albani, Diego, Zandi, Peter, Potash, James B., Zhang, Peng, Raymond Depaulo, J., Bergen, Sarah E., Juréus, Anders, Karlsson, Robert, Kandaswamy, Radhika, Mcguffin, Peter, Rivera, Margarita, Lissowska, Jolanta, Cruceanu, Cristiana, Lucae, Susanne, Cervantes, Pablo, Budde, Monika, Gade, Katrin, Heilbronner, Urs, Pedersen, Marianne Giørtz, Morris, Derek W., Weickert, Cynthia Shannon, Weickert, Thomas W., Macintyre, Donald J., Lawrence, Jacob, Elvsåshagen, Torbjørn, Smeland, Olav B., Djurovic, Srdjan, Xi, Simon, Green, Elaine K., Czerski, Piotr M., Hauser, Joanna, Xu, Wei, Vedder, Helmut, Oruc, Lilijana, Spijker, Anne T., Gordon, Scott D., Medland, Sarah E., Curtis, David, Mühleisen, Thomas W., Badner, Judith, Scheftner, William A., Sigurdsson, Engilbert, Schork, Nicholas J., Schatzberg, Alan F., Bækvad-Hansen, Marie, Bybjerg-Grauholm, Jonas, Hansen, Christine Søholm, Knowles, James A., Szelinger, Szabolcs, Montgomery, Grant W., Boks, Marco, Adolfsson, Annelie Nordin, Hoffmann, Per, Bauer, Michael, Pfennig, Andrea, Leber, Markus, Kittel-Schneider, Sarah, Reif, Andreas, Del-Favero, Jurgen, Fischer, Sascha B., Herms, Stefan, Reinbold, Céline S., Degenhardt, Franziska, Koller, Anna C., Maaser, Anna, Ori, Anil, Dale, Anders M., Fan, Chun Chieh, Greenwood, Tiffany A., Nievergelt, Caroline M., Shehktman, Tatyana, Shilling, Paul D., Byerley, William, Bunney, William, Alliey-Rodriguez, Ney, Clarke, Toni Kim, Liu, Chunyu, Coryell, William, Akil, Huda, Burmeister, Margit, Flickinger, Matthew, Li, Jun Z., Mcinnis, Melvin G., Meng, Fan, Thompson, Robert C., Watson, Stanley J., Zollner, Sebastian, Guan, Weihua, Green, Melissa J., Craig, David, Sobell, Janet L., Milani, Lili, Gordon-Smith, Katherine, Knott, Sarah V., Perry, Amy, Parra, José Guzman, Mayoral, Fermin, Rivas, Fabio, Rice, John P., Barchas, Jack D., Børglum, Anders D., Mortensen, Preben Bo, Mors, Ole, Grigoroiu-Serbanescu, Maria, Bellivier, Frank, Etain, Bruno, Leboyer, Marion, Ramos-Quiroga, Josep Antoni, Agartz, Ingrid, Amin, Farooq, Azevedo, Maria H., Bass, Nicholas, Black, Donald W., Blackwood, Douglas H.R., Bruggeman, Richard, Buccola, Nancy G., Choudhury, Khalid, Cloninger, C. Robert, Corvin, Aiden, Craddock, Nicholas, Daly, Mark J., Datta, Susmita, Donohoe, Gary J., Duan, Jubao, Dudbridge, Frank, Fanous, Ayman, Freedman, Robert, Freimer, Nelson B., Friedl, Marion, Gill, Michael, Gurling, Hugh, De Haan, Lieuwe, Hamshere, Marian L., Hartmann, Annette M., Holmans, Peter A., Kahn, René S., Keller, Matthew C., Kenny, Elaine, Kirov, George K., Krabbendam, Lydia, Krasucki, Robert, Lencz, Todd, Levinson, Douglas F., Lieberman, Jeffrey A., Lin, Dan Yu, Linszen, Don H., Magnusson, Patrik K.E., Maier, Wolfgang, Malhotra, Anil K., Mattheisen, Manuel, Mattingsdal, Morten, Mccarroll, Steven A., Medeiros, Helena, Melle, Ingrid, Milanova, Vihra, Myin-Germeys, Inez, Neale, Benjamin M., Ophoff, Roel A., Owen, Michael J., Pimm, Jonathan, Purcell, Shaun M., Puri, Vinay, Quested, Digby J., Rossin, Lizzy, Sanders, Alan R., Shi, Jianxin, Sklar, Pamela, St Clair, David, Stroup, T. Scott, Van Os, Jim, Wiersma, Durk, Zammit, Stanley, Maier, Robert M., Zhu, Zhihong, Lee, Sang Hong, Trzaskowski, Maciej, Ruderfer, Douglas M., Stahl, Eli A., Ripke, Stephan, Wray, Naomi R., Yang, Jian, Visscher, Peter M., Robinson, Matthew R., Forstner, Andreas J., Mcquillin, Andrew, Trubetskoy, Vassily, Wang, Weiqing, Wang, Yunpeng, Coleman, Jonathan R.I., Gaspar, Héléna A., De Leeuw, Christiaan A., Whitehead Pavlides, Jennifer M., Olde Loohuis, Loes M., Pers, Tune H., Lee, Phil H., Charney, Alexander W., Dobbyn, Amanda L., Huckins, Laura, Boocock, James, Giambartolomei, Claudia, Roussos, Panos, Mullins, Niamh, Awasthi, Swapnil, Agerbo, Esben, Als, Thomas D., Pedersen, Carsten Bøcker, Grove, Jakob, Kupka, Ralph, Regeer, Eline J., Anjorin, Adebayo, Casas, Miquel, Mahon, Pamela B., Allardyce, Judith, Escott-Price, Valentina, Forty, Liz, Fraser, Christine, Kogevinas, Manolis, Frank, Josef, Streit, Fabian, Strohmaier, Jana, Treutlein, Jens, Witt, Stephanie H., Kennedy, James L., Strauss, John S., Garnham, Julie, O'donovan, Claire, Slaney, Claire, Steinberg, Stacy, Thorgeirsson, Thorgeir E., Hautzinger, Martin, Steffens, Michael, Perlis, Roy H., Sánchez-Mora, Cristina, Hipolito, Maria, Lawson, William B., Nwulia, Evaristus A., Levy, Shawn E., Foroud, Tatiana M., Jamain, Stéphane, Young, Allan H., Mckay, James D., Albani, Diego, Zandi, Peter, Potash, James B., Zhang, Peng, Raymond Depaulo, J., Bergen, Sarah E., Juréus, Anders, Karlsson, Robert, Kandaswamy, Radhika, Mcguffin, Peter, Rivera, Margarita, Lissowska, Jolanta, Cruceanu, Cristiana, Lucae, Susanne, Cervantes, Pablo, Budde, Monika, Gade, Katrin, Heilbronner, Urs, Pedersen, Marianne Giørtz, Morris, Derek W., Weickert, Cynthia Shannon, Weickert, Thomas W., Macintyre, Donald J., Lawrence, Jacob, Elvsåshagen, Torbjørn, Smeland, Olav B., Djurovic, Srdjan, Xi, Simon, Green, Elaine K., Czerski, Piotr M., Hauser, Joanna, Xu, Wei, Vedder, Helmut, Oruc, Lilijana, Spijker, Anne T., Gordon, Scott D., Medland, Sarah E., Curtis, David, Mühleisen, Thomas W., Badner, Judith, Scheftner, William A., Sigurdsson, Engilbert, Schork, Nicholas J., Schatzberg, Alan F., Bækvad-Hansen, Marie, Bybjerg-Grauholm, Jonas, Hansen, Christine Søholm, Knowles, James A., Szelinger, Szabolcs, Montgomery, Grant W., Boks, Marco, Adolfsson, Annelie Nordin, Hoffmann, Per, Bauer, Michael, Pfennig, Andrea, Leber, Markus, Kittel-Schneider, Sarah, Reif, Andreas, Del-Favero, Jurgen, Fischer, Sascha B., Herms, Stefan, Reinbold, Céline S., Degenhardt, Franziska, Koller, Anna C., Maaser, Anna, Ori, Anil, Dale, Anders M., Fan, Chun Chieh, Greenwood, Tiffany A., Nievergelt, Caroline M., Shehktman, Tatyana, Shilling, Paul D., Byerley, William, Bunney, William, Alliey-Rodriguez, Ney, Clarke, Toni Kim, Liu, Chunyu, Coryell, William, Akil, Huda, Burmeister, Margit, Flickinger, Matthew, Li, Jun Z., Mcinnis, Melvin G., Meng, Fan, Thompson, Robert C., Watson, Stanley J., Zollner, Sebastian, Guan, Weihua, Green, Melissa J., Craig, David, Sobell, Janet L., Milani, Lili, Gordon-Smith, Katherine, Knott, Sarah V., Perry, Amy, Parra, José Guzman, Mayoral, Fermin, Rivas, Fabio, Rice, John P., Barchas, Jack D., Børglum, Anders D., Mortensen, Preben Bo, Mors, Ole, Grigoroiu-Serbanescu, Maria, Bellivier, Frank, Etain, Bruno, Leboyer, Marion, Ramos-Quiroga, Josep Antoni, Agartz, Ingrid, Amin, Farooq, Azevedo, Maria H., Bass, Nicholas, Black, Donald W., Blackwood, Douglas H.R., Bruggeman, Richard, Buccola, Nancy G., Choudhury, Khalid, Cloninger, C. Robert, Corvin, Aiden, Craddock, Nicholas, Daly, Mark J., Datta, Susmita, Donohoe, Gary J., Duan, Jubao, Dudbridge, Frank, Fanous, Ayman, Freedman, Robert, Freimer, Nelson B., Friedl, Marion, Gill, Michael, Gurling, Hugh, De Haan, Lieuwe, Hamshere, Marian L., Hartmann, Annette M., Holmans, Peter A., Kahn, René S., Keller, Matthew C., Kenny, Elaine, Kirov, George K., Krabbendam, Lydia, Krasucki, Robert, Lencz, Todd, Levinson, Douglas F., Lieberman, Jeffrey A., Lin, Dan Yu, Linszen, Don H., Magnusson, Patrik K.E., Maier, Wolfgang, Malhotra, Anil K., Mattheisen, Manuel, Mattingsdal, Morten, Mccarroll, Steven A., Medeiros, Helena, Melle, Ingrid, Milanova, Vihra, Myin-Germeys, Inez, Neale, Benjamin M., Ophoff, Roel A., Owen, Michael J., Pimm, Jonathan, Purcell, Shaun M., Puri, Vinay, Quested, Digby J., Rossin, Lizzy, Sanders, Alan R., Shi, Jianxin, Sklar, Pamela, St Clair, David, Stroup, T. Scott, Van Os, Jim, Wiersma, Durk, and Zammit, Stanley

Published
2018

46. Improving genetic prediction by leveraging genetic correlations among human diseases and traits

Author

Onderzoeksgroep 2, Brain, Onderzoeksgroep 11, Hersenen-Bedrijfsvoering, Maier, Robert M., Zhu, Zhihong, Lee, Sang Hong, Trzaskowski, Maciej, Ruderfer, Douglas M., Stahl, Eli A., Ripke, Stephan, Wray, Naomi R., Yang, Jian, Visscher, Peter M., Robinson, Matthew R., Forstner, Andreas J., Mcquillin, Andrew, Trubetskoy, Vassily, Wang, Weiqing, Wang, Yunpeng, Coleman, Jonathan R.I., Gaspar, Héléna A., De Leeuw, Christiaan A., Whitehead Pavlides, Jennifer M., Olde Loohuis, Loes M., Pers, Tune H., Lee, Phil H., Charney, Alexander W., Dobbyn, Amanda L., Huckins, Laura, Boocock, James, Giambartolomei, Claudia, Roussos, Panos, Mullins, Niamh, Awasthi, Swapnil, Agerbo, Esben, Als, Thomas D., Pedersen, Carsten Bøcker, Grove, Jakob, Kupka, Ralph, Regeer, Eline J., Anjorin, Adebayo, Casas, Miquel, Mahon, Pamela B., Allardyce, Judith, Escott-Price, Valentina, Forty, Liz, Fraser, Christine, Kogevinas, Manolis, Frank, Josef, Streit, Fabian, Strohmaier, Jana, Treutlein, Jens, Witt, Stephanie H., Kennedy, James L., Strauss, John S., Garnham, Julie, O'donovan, Claire, Slaney, Claire, Steinberg, Stacy, Thorgeirsson, Thorgeir E., Hautzinger, Martin, Steffens, Michael, Perlis, Roy H., Sánchez-Mora, Cristina, Hipolito, Maria, Lawson, William B., Nwulia, Evaristus A., Levy, Shawn E., Foroud, Tatiana M., Jamain, Stéphane, Young, Allan H., Mckay, James D., Albani, Diego, Zandi, Peter, Potash, James B., Zhang, Peng, Raymond Depaulo, J., Bergen, Sarah E., Juréus, Anders, Karlsson, Robert, Kandaswamy, Radhika, Mcguffin, Peter, Rivera, Margarita, Lissowska, Jolanta, Cruceanu, Cristiana, Lucae, Susanne, Cervantes, Pablo, Budde, Monika, Gade, Katrin, Heilbronner, Urs, Pedersen, Marianne Giørtz, Morris, Derek W., Weickert, Cynthia Shannon, Weickert, Thomas W., Macintyre, Donald J., Lawrence, Jacob, Elvsåshagen, Torbjørn, Smeland, Olav B., Djurovic, Srdjan, Xi, Simon, Green, Elaine K., Czerski, Piotr M., Hauser, Joanna, Xu, Wei, Vedder, Helmut, Oruc, Lilijana, Spijker, Anne T., Gordon, Scott D., Medland, Sarah E., Curtis, David, Mühleisen, Thomas W., Badner, Judith, Scheftner, William A., Sigurdsson, Engilbert, Schork, Nicholas J., Schatzberg, Alan F., Bækvad-Hansen, Marie, Bybjerg-Grauholm, Jonas, Hansen, Christine Søholm, Knowles, James A., Szelinger, Szabolcs, Montgomery, Grant W., Boks, Marco, Adolfsson, Annelie Nordin, Hoffmann, Per, Bauer, Michael, Pfennig, Andrea, Leber, Markus, Kittel-Schneider, Sarah, Reif, Andreas, Del-Favero, Jurgen, Fischer, Sascha B., Herms, Stefan, Reinbold, Céline S., Degenhardt, Franziska, Koller, Anna C., Maaser, Anna, Ori, Anil, Dale, Anders M., Fan, Chun Chieh, Greenwood, Tiffany A., Nievergelt, Caroline M., Shehktman, Tatyana, Shilling, Paul D., Byerley, William, Bunney, William, Alliey-Rodriguez, Ney, Clarke, Toni Kim, Liu, Chunyu, Coryell, William, Akil, Huda, Burmeister, Margit, Flickinger, Matthew, Li, Jun Z., Mcinnis, Melvin G., Meng, Fan, Thompson, Robert C., Watson, Stanley J., Zollner, Sebastian, Guan, Weihua, Green, Melissa J., Craig, David, Sobell, Janet L., Milani, Lili, Gordon-Smith, Katherine, Knott, Sarah V., Perry, Amy, Parra, José Guzman, Mayoral, Fermin, Rivas, Fabio, Rice, John P., Barchas, Jack D., Børglum, Anders D., Mortensen, Preben Bo, Mors, Ole, Grigoroiu-Serbanescu, Maria, Bellivier, Frank, Etain, Bruno, Leboyer, Marion, Ramos-Quiroga, Josep Antoni, Agartz, Ingrid, Amin, Farooq, Azevedo, Maria H., Bass, Nicholas, Black, Donald W., Blackwood, Douglas H.R., Bruggeman, Richard, Buccola, Nancy G., Choudhury, Khalid, Cloninger, C. Robert, Corvin, Aiden, Craddock, Nicholas, Daly, Mark J., Datta, Susmita, Donohoe, Gary J., Duan, Jubao, Dudbridge, Frank, Fanous, Ayman, Freedman, Robert, Freimer, Nelson B., Friedl, Marion, Gill, Michael, Gurling, Hugh, De Haan, Lieuwe, Hamshere, Marian L., Hartmann, Annette M., Holmans, Peter A., Kahn, René S., Keller, Matthew C., Kenny, Elaine, Kirov, George K., Krabbendam, Lydia, Krasucki, Robert, Lencz, Todd, Levinson, Douglas F., Lieberman, Jeffrey A., Lin, Dan Yu, Linszen, Don H., Magnusson, Patrik K.E., Maier, Wolfgang, Malhotra, Anil K., Mattheisen, Manuel, Mattingsdal, Morten, Mccarroll, Steven A., Medeiros, Helena, Melle, Ingrid, Milanova, Vihra, Myin-Germeys, Inez, Neale, Benjamin M., Ophoff, Roel A., Owen, Michael J., Pimm, Jonathan, Purcell, Shaun M., Puri, Vinay, Quested, Digby J., Rossin, Lizzy, Sanders, Alan R., Shi, Jianxin, Sklar, Pamela, St Clair, David, Stroup, T. Scott, Van Os, Jim, Wiersma, Durk, Zammit, Stanley, Onderzoeksgroep 2, Brain, Onderzoeksgroep 11, Hersenen-Bedrijfsvoering, Maier, Robert M., Zhu, Zhihong, Lee, Sang Hong, Trzaskowski, Maciej, Ruderfer, Douglas M., Stahl, Eli A., Ripke, Stephan, Wray, Naomi R., Yang, Jian, Visscher, Peter M., Robinson, Matthew R., Forstner, Andreas J., Mcquillin, Andrew, Trubetskoy, Vassily, Wang, Weiqing, Wang, Yunpeng, Coleman, Jonathan R.I., Gaspar, Héléna A., De Leeuw, Christiaan A., Whitehead Pavlides, Jennifer M., Olde Loohuis, Loes M., Pers, Tune H., Lee, Phil H., Charney, Alexander W., Dobbyn, Amanda L., Huckins, Laura, Boocock, James, Giambartolomei, Claudia, Roussos, Panos, Mullins, Niamh, Awasthi, Swapnil, Agerbo, Esben, Als, Thomas D., Pedersen, Carsten Bøcker, Grove, Jakob, Kupka, Ralph, Regeer, Eline J., Anjorin, Adebayo, Casas, Miquel, Mahon, Pamela B., Allardyce, Judith, Escott-Price, Valentina, Forty, Liz, Fraser, Christine, Kogevinas, Manolis, Frank, Josef, Streit, Fabian, Strohmaier, Jana, Treutlein, Jens, Witt, Stephanie H., Kennedy, James L., Strauss, John S., Garnham, Julie, O'donovan, Claire, Slaney, Claire, Steinberg, Stacy, Thorgeirsson, Thorgeir E., Hautzinger, Martin, Steffens, Michael, Perlis, Roy H., Sánchez-Mora, Cristina, Hipolito, Maria, Lawson, William B., Nwulia, Evaristus A., Levy, Shawn E., Foroud, Tatiana M., Jamain, Stéphane, Young, Allan H., Mckay, James D., Albani, Diego, Zandi, Peter, Potash, James B., Zhang, Peng, Raymond Depaulo, J., Bergen, Sarah E., Juréus, Anders, Karlsson, Robert, Kandaswamy, Radhika, Mcguffin, Peter, Rivera, Margarita, Lissowska, Jolanta, Cruceanu, Cristiana, Lucae, Susanne, Cervantes, Pablo, Budde, Monika, Gade, Katrin, Heilbronner, Urs, Pedersen, Marianne Giørtz, Morris, Derek W., Weickert, Cynthia Shannon, Weickert, Thomas W., Macintyre, Donald J., Lawrence, Jacob, Elvsåshagen, Torbjørn, Smeland, Olav B., Djurovic, Srdjan, Xi, Simon, Green, Elaine K., Czerski, Piotr M., Hauser, Joanna, Xu, Wei, Vedder, Helmut, Oruc, Lilijana, Spijker, Anne T., Gordon, Scott D., Medland, Sarah E., Curtis, David, Mühleisen, Thomas W., Badner, Judith, Scheftner, William A., Sigurdsson, Engilbert, Schork, Nicholas J., Schatzberg, Alan F., Bækvad-Hansen, Marie, Bybjerg-Grauholm, Jonas, Hansen, Christine Søholm, Knowles, James A., Szelinger, Szabolcs, Montgomery, Grant W., Boks, Marco, Adolfsson, Annelie Nordin, Hoffmann, Per, Bauer, Michael, Pfennig, Andrea, Leber, Markus, Kittel-Schneider, Sarah, Reif, Andreas, Del-Favero, Jurgen, Fischer, Sascha B., Herms, Stefan, Reinbold, Céline S., Degenhardt, Franziska, Koller, Anna C., Maaser, Anna, Ori, Anil, Dale, Anders M., Fan, Chun Chieh, Greenwood, Tiffany A., Nievergelt, Caroline M., Shehktman, Tatyana, Shilling, Paul D., Byerley, William, Bunney, William, Alliey-Rodriguez, Ney, Clarke, Toni Kim, Liu, Chunyu, Coryell, William, Akil, Huda, Burmeister, Margit, Flickinger, Matthew, Li, Jun Z., Mcinnis, Melvin G., Meng, Fan, Thompson, Robert C., Watson, Stanley J., Zollner, Sebastian, Guan, Weihua, Green, Melissa J., Craig, David, Sobell, Janet L., Milani, Lili, Gordon-Smith, Katherine, Knott, Sarah V., Perry, Amy, Parra, José Guzman, Mayoral, Fermin, Rivas, Fabio, Rice, John P., Barchas, Jack D., Børglum, Anders D., Mortensen, Preben Bo, Mors, Ole, Grigoroiu-Serbanescu, Maria, Bellivier, Frank, Etain, Bruno, Leboyer, Marion, Ramos-Quiroga, Josep Antoni, Agartz, Ingrid, Amin, Farooq, Azevedo, Maria H., Bass, Nicholas, Black, Donald W., Blackwood, Douglas H.R., Bruggeman, Richard, Buccola, Nancy G., Choudhury, Khalid, Cloninger, C. Robert, Corvin, Aiden, Craddock, Nicholas, Daly, Mark J., Datta, Susmita, Donohoe, Gary J., Duan, Jubao, Dudbridge, Frank, Fanous, Ayman, Freedman, Robert, Freimer, Nelson B., Friedl, Marion, Gill, Michael, Gurling, Hugh, De Haan, Lieuwe, Hamshere, Marian L., Hartmann, Annette M., Holmans, Peter A., Kahn, René S., Keller, Matthew C., Kenny, Elaine, Kirov, George K., Krabbendam, Lydia, Krasucki, Robert, Lencz, Todd, Levinson, Douglas F., Lieberman, Jeffrey A., Lin, Dan Yu, Linszen, Don H., Magnusson, Patrik K.E., Maier, Wolfgang, Malhotra, Anil K., Mattheisen, Manuel, Mattingsdal, Morten, Mccarroll, Steven A., Medeiros, Helena, Melle, Ingrid, Milanova, Vihra, Myin-Germeys, Inez, Neale, Benjamin M., Ophoff, Roel A., Owen, Michael J., Pimm, Jonathan, Purcell, Shaun M., Puri, Vinay, Quested, Digby J., Rossin, Lizzy, Sanders, Alan R., Shi, Jianxin, Sklar, Pamela, St Clair, David, Stroup, T. Scott, Van Os, Jim, Wiersma, Durk, and Zammit, Stanley

Published
2018

48. Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

Author

Ruderfer, Douglas M., primary, Ripke, Stephan, additional, McQuillin, Andrew, additional, Boocock, James, additional, Stahl, Eli A., additional, Pavlides, Jennifer M. Whitehead, additional, Mullins, Niamh, additional, Charney, Alexander W., additional, Ori, Anil P.S., additional, Loohuis, Loes M. Olde, additional, Domenici, Enrico, additional, Di Florio, Arianna, additional, Papiol, Sergi, additional, Kalman, Janos L., additional, Trubetskoy, Vassily, additional, Adolfsson, Rolf, additional, Agartz, Ingrid, additional, Agerbo, Esben, additional, Akil, Huda, additional, Albani, Diego, additional, Albus, Margot, additional, Alda, Martin, additional, Alexander, Madeline, additional, Alliey-Rodriguez, Ney, additional, Als, Thomas D., additional, Amin, Farooq, additional, Anjorin, Adebayo, additional, Arranz, Maria J., additional, Awasthi, Swapnil, additional, Bacanu, Silviu A., additional, Badner, Judith A., additional, Baekvad-Hansen, Marie, additional, Bakker, Steven, additional, Band, Gavin, additional, Barchas, Jack D., additional, Barroso, Ines, additional, Bass, Nicholas, additional, Bauer, Michael, additional, Baune, Bernhard T., additional, Begemann, Martin, additional, Bellenguez, Celine, additional, Belliveau, Richard A., additional, Bellivier, Frank, additional, Bender, Stephan, additional, Bene, Judit, additional, Bergen, Sarah E., additional, Berrettini, Wade H., additional, Bevilacqua, Elizabeth, additional, Biernacka, Joanna M., additional, Bigdeli, Tim B., additional, Black, Donald W., additional, Blackburn, Hannah, additional, Blackwell, Jenefer M., additional, Blackwood, Douglas H.R., additional, Pedersen, Carsten Bocker, additional, Boehnke, Michael, additional, Boks, Marco, additional, Borglum, Anders D., additional, Bramon, Elvira, additional, Breen, Gerome, additional, Brown, Matthew A., additional, Bruggeman, Richard, additional, Buccola, Nancy G., additional, Buckner, Randy L., additional, Budde, Monika, additional, Bulik-Sullivan, Brendan, additional, Bumpstead, Suzannah J., additional, Bunney, William, additional, Burmeister, Margit, additional, Buxbaum, Joseph D., additional, Bybjerg-Grauholm, Jonas, additional, Byerley, William, additional, Cahn, Wiepke, additional, Cai, Guiqing, additional, Cairns, Murray J., additional, Campion, Dominique, additional, Cantor, Rita M., additional, Carr, Vaughan J., additional, Carrera, Noa, additional, Casas, Juan P., additional, Casas, Miquel, additional, Catts, Stanley V., additional, Cervantes, Pablo, additional, Chambert, Kimberley D., additional, Chan, Raymond C.K., additional, Chen, Eric Y.H., additional, Chen, Ronald Y.L., additional, Cheng, Wei, additional, Cheung, Eric F.C., additional, Chong, Siow Ann, additional, Clarke, Toni-Kim, additional, Cloninger, C. Robert, additional, Cohen, David, additional, Cohen, Nadine, additional, Coleman, Jonathan R.I., additional, Collier, David A., additional, Cormican, Paul, additional, Coryell, William, additional, Craddock, Nicholas, additional, Craig, David W., additional, Crespo-Facorro, Benedicto, additional, Crowley, James J., additional, Cruceanu, Cristiana, additional, Curtis, David, additional, Czerski, Piotr M., additional, Dale, Anders M., additional, Daly, Mark J., additional, Dannlowski, Udo, additional, Darvasi, Ariel, additional, Davidson, Michael, additional, Davis, Kenneth L., additional, de Leeuw, Christiaan A., additional, Degenhardt, Franziska, additional, Del Favero, Jurgen, additional, DeLisi, Lynn E., additional, Deloukas, Panos, additional, Demontis, Ditte, additional, DePaulo, J. Raymond, additional, di Forti, Marta, additional, Dikeos, Dimitris, additional, Dinan, Timothy, additional, Djurovic, Srdjan, additional, Dobbyn, Amanda L., additional, Donnelly, Peter, additional, Donohoe, Gary, additional, Drapeau, Elodie, additional, Dronov, Serge, additional, Duan, Jubao, additional, Dudbridge, Frank, additional, Duncanson, Audrey, additional, Edenberg, Howard, additional, Edkins, Sarah, additional, Ehrenreich, Hannelore, additional, Eichhammer, Peter, additional, Elvsashagen, Torbjorn, additional, Eriksson, Johan, additional, Escott-Price, Valentina, additional, Esko, Tonu, additional, Essioux, Laurent, additional, Etain, Bruno, additional, Fan, Chun Chieh, additional, Farh, Kai-How, additional, Farrell, Martilias S., additional, Flickinger, Matthew, additional, Foroud, Tatiana M., additional, Forty, Liz, additional, Frank, Josef, additional, Franke, Lude, additional, Fraser, Christine, additional, Freedman, Robert, additional, Freeman, Colin, additional, Freimer, Nelson B., additional, Friedman, Joseph I., additional, Fromer, Menachem, additional, Frye, Mark A., additional, Fullerton, Janice M., additional, Gade, Katrin, additional, Garnham, Julie, additional, Gaspar, Helena A., additional, Gejman, Pablo V., additional, Genovese, Giulio, additional, Georgieva, Lyudmila, additional, Giambartolomei, Claudia, additional, Giannoulatou, Eleni, additional, Giegling, Ina, additional, Gill, Michael, additional, Gillman, Matthew, additional, Pedersen, Marianne Giortz, additional, Giusti-Rodriguez, Paola, additional, Godard, Stephanie, additional, Goes, Fernando, additional, Goldstein, Jacqueline I., additional, Gopal, Srihari, additional, Gordon, Scott D., additional, Gordon-Smith, Katherine, additional, Gratten, Jacob, additional, Gray, Emma, additional, Green, Elaine K., additional, Green, Melissa J., additional, Greenwood, Tiffany A., additional, Grigoroiu-Serbanescu, Maria, additional, Grove, Jakob, additional, Guan, Weihua, additional, Gurling, Hugh, additional, Parra, Jose Guzman, additional, Gwilliam, Rhian, additional, de Haan, Lieuwe, additional, Hall, Jeremy, additional, Hall, Mei-Hua, additional, Hammer, Christian, additional, Hammond, Naomi, additional, Hamshere, Marian L., additional, Hansen, Mark, additional, Hansen, Thomas, additional, Haroutunian, Vahram, additional, Hartmann, Annette M., additional, Hauser, Joanna, additional, Hautzinger, Martin, additional, Heilbronner, Urs, additional, Hellenthal, Garrett, additional, Henskens, Frans A., additional, Herms, Stefan, additional, Hipolito, Maria, additional, Hirschhorn, Joel N., additional, Hoffmann, Per, additional, Hollegaard, Mads V., additional, Hougaard, David M., additional, Huang, Hailiang, additional, Huckins, Laura, additional, Hultman, Christina M., additional, Hunt, Sarah E., additional, Ikeda, Masashi, additional, Iwata, Nakao, additional, Iyegbe, Conrad, additional, Jablensky, Assen V., additional, Jamain, Stephane, additional, Jankowski, Janusz, additional, Jayakumar, Alagurevathi, additional, Joa, Inge, additional, Jones, Ian, additional, Jones, Lisa A., additional, Jonsson, Erik G., additional, Julia, Antonio, additional, Jureus, Anders, additional, Kahler, Anna K., additional, Kahn, Rene S., additional, Kalaydjieva, Luba, additional, Kandaswamy, Radhika, additional, Karachanak-Yankova, Sena, additional, Karjalainen, Juha, additional, Karlsson, Robert, additional, Kavanagh, David, additional, Keller, Matthew C., additional, Kelly, Brian J., additional, Kelsoe, John, additional, Kennedy, James L., additional, Khrunin, Andrey, additional, Kim, Yunjung, additional, Kirov, George, additional, Kittel-Schneider, Sarah, additional, Klovins, Janis, additional, Knight, Jo, additional, Knott, Sarah V., additional, Knowles, James A., additional, Kogevinas, Manolis, additional, Konte, Bettina, additional, Kravariti, Eugenia, additional, Kucinskas, Vaidutis, additional, Kucinskiene, Zita Ausrele, additional, Kupka, Ralph, additional, Kuzelova-Ptackova, Hana, additional, Landen, Mikael, additional, Langford, Cordelia, additional, Laurent, Claudine, additional, Lawrence, Jacob, additional, Lawrie, Stephen, additional, Lawson, William B., additional, Leber, Markus, additional, Leboyer, Marion, additional, Lee, Phil H., additional, Keong, Jimmy Lee Chee, additional, Legge, Sophie E., additional, Lencz, Todd, additional, Lerer, Bernard, additional, Levinson, Douglas F., additional, Levy, Shawn E., additional, Lewis, Cathryn M., additional, Li, Jun Z., additional, Li, Miaoxin, additional, Li, Qingqin S., additional, Li, Tao, additional, Liang, Kung-Yee, additional, Liddle, Jennifer, additional, Lieberman, Jeffrey, additional, Limborska, Svetlana, additional, Lin, Kuang, additional, Linszen, Don H., additional, Lissowska, Jolanta, additional, Liu, Chunyu, additional, Liu, Jianjun, additional, Lonnqvist, Jouko, additional, Loughland, Carmel M., additional, Lubinski, Jan, additional, Lucae, Susanne, additional, Macek, Milan, additional, MacIntyre, Donald J., additional, Magnusson, Patrik K.E., additional, Maher, Brion S., additional, Mahon, Pamela B., additional, Maier, Wolfgang, additional, Malhotra, Anil K., additional, Mallet, Jacques, additional, Malt, Ulrik F., additional, Markus, Hugh S., additional, Marsal, Sara, additional, Martin, Nicholas G., additional, Mata, Ignacio, additional, Mathew, Christopher G., additional, Mattheisen, Manuel, additional, Mattingsdal, Morten, additional, Mayoral, Fermin, additional, McCann, Owen T., additional, McCarley, Robert W., additional, McCarroll, Steven A., additional, McCarthy, Mark I., additional, McDonald, Colm, additional, McElroy, Susan L., additional, McGuffin, Peter, additional, McInnis, Melvin G., additional, McIntosh, Andrew M., additional, McKay, James D., additional, McMahon, Francis J., additional, Medeiros, Helena, additional, Medland, Sarah E., additional, Meier, Sandra, additional, Meijer, Carin J., additional, Melegh, Bela, additional, Melle, Ingrid, additional, Meng, Fan, additional, Mesholam-Gately, Raquelle I., additional, Metspalu, Andres, additional, Michie, Patricia T., additional, Milani, Lili, additional, Milanova, Vihra, additional, Mitchell, Philip B., additional, Mokrab, Younes, additional, Montgomery, Grant W., additional, Moran, Jennifer L., additional, Morken, Gunnar, additional, Morris, Derek W., additional, Mors, Ole, additional, Mortensen, Preben B., additional, Mowry, Bryan J., additional, Mühleisen, Thomas W., additional, Müller-Myhsok, Bertram, additional, Murphy, Kieran C., additional, Murray, Robin M., additional, Myers, Richard M., additional, Myin-Germeys, Inez, additional, Neale, Benjamin M., additional, Nelis, Mari, additional, Nenadic, Igor, additional, Nertney, Deborah A., additional, Nestadt, Gerald, additional, Nicodemus, Kristin K., additional, Nievergelt, Caroline M., additional, Nikitina-Zake, Liene, additional, Nimgaonkar, Vishwajit, additional, Nisenbaum, Laura, additional, Nordentoft, Merete, additional, Nordin, Annelie, additional, Nöthen, Markus M., additional, Nwulia, Evaristus A., additional, O’Callaghan, Eadbhard, additional, O’Donovan, Claire, additional, O’Dushlaine, Colm, additional, O’Neill, F. Anthony, additional, Oedegaard, Ketil J., additional, Oh, Sang-Yun, additional, Olincy, Ann, additional, Olsen, Line, additional, Oruc, Lilijana, additional, Van Os, Jim, additional, Owen, Michael J., additional, Paciga, Sara A., additional, Palmer, Colin N.A., additional, Palotie, Aarno, additional, Pantelis, Christos, additional, Papadimitriou, George N., additional, Parkhomenko, Elena, additional, Pato, Carlos, additional, Pato, Michele T., additional, Paunio, Tiina, additional, Pearson, Richard, additional, Perkins, Diana O., additional, Perlis, Roy H., additional, Perry, Amy, additional, Pers, Tune H., additional, Petryshen, Tracey L., additional, Pfennig, Andrea, additional, Picchioni, Marco, additional, Pietilainen, Olli, additional, Pimm, Jonathan, additional, Pirinen, Matti, additional, Plomin, Robert, additional, Pocklington, Andrew J., additional, Posthuma, Danielle, additional, Potash, James B., additional, Potter, Simon C., additional, Powell, John, additional, Price, Alkes, additional, Pulver, Ann E., additional, Purcell, Shaun M., additional, Quested, Digby, additional, Ramos-Quiroga, Josep Antoni, additional, Rasmussen, Henrik B., additional, Rautanen, Anna, additional, Ravindrarajah, Radhi, additional, Regeer, Eline J., additional, Reichenberg, Abraham, additional, Reif, Andreas, additional, Reimers, Mark A., additional, Ribases, Marta, additional, Rice, John P., additional, Richards, Alexander L., additional, Ricketts, Michelle, additional, Riley, Brien P., additional, Rivas, Fabio, additional, Rivera, Margarita, additional, Roffman, Joshua L., additional, Rouleau, Guy A., additional, Roussos, Panos, additional, Rujescu, Dan, additional, Salomaa, Veikko, additional, Sanchez-Mora, Cristina, additional, Sanders, Alan R., additional, Sawcer, Stephen J., additional, Schall, Ulrich, additional, Schatzberg, Alan F., additional, Scheftner, William A., additional, Schofield, Peter R., additional, Schork, Nicholas J., additional, Schwab, Sibylle G., additional, Scolnick, Edward M., additional, Scott, Laura J., additional, Scott, Rodney J., additional, Seidman, Larry J., additional, Serretti, Alessandro, additional, Sham, Pak C., additional, Weickert, Cynthia Shannon, additional, Shehktman, Tatyana, additional, Shi, Jianxin, additional, Shilling, Paul D., additional, Sigurdsson, Engilbert, additional, Silverman, Jeremy M., additional, Sim, Kang, additional, Slaney, Claire, additional, Slominsky, Petr, additional, Smeland, Olav B., additional, Smoller, Jordan W., additional, So, Hon-Cheong, additional, Sobell, Janet L., additional, Soderman, Erik, additional, Hansen, Christine Soholm, additional, Spencer, Chris C.A., additional, Spijker, Anne T., additional, St Clair, David, additional, Stefansson, Hreinn, additional, Stefansson, Kari, additional, Steinberg, Stacy, additional, Stogmann, Elisabeth, additional, Stordal, Eystein, additional, Strange, Amy, additional, Straub, Richard E., additional, Strauss, John S., additional, Streit, Fabian, additional, Strengman, Eric, additional, Strohmaier, Jana, additional, Stroup, T. Scott, additional, Su, Zhan, additional, Subramaniam, Mythily, additional, Suvisaari, Jaana, additional, Svrakic, Dragan M., additional, Szatkiewicz, Jin P., additional, Szelinger, Szabolcs, additional, Tashakkori-Ghanbaria, Avazeh, additional, Thirumalai, Srinivas, additional, Thompson, Robert C., additional, Thorgeirsson, Thorgeir E., additional, Toncheva, Draga, additional, Tooney, Paul A., additional, Tosato, Sarah, additional, Toulopoulou, Timothea, additional, Trembath, Richard C., additional, Treutlein, Jens, additional, Turecki, Gustavo, additional, Vaaler, Arne E., additional, Vedder, Helmut, additional, Vieta, Eduard, additional, Vincent, John, additional, Visscher, Peter M., additional, Viswanathan, Ananth C., additional, Vukcevic, Damjan, additional, Waddington, John, additional, Waller, Matthew, additional, Walsh, Dermot, additional, Walshe, Muriel, additional, Walters, James T.R., additional, Wang, Dai, additional, Wang, Qiang, additional, Wang, Weiqing, additional, Wang, Yunpeng, additional, Watson, Stanley J., additional, Webb, Bradley T., additional, Weickert, Thomas W., additional, Weinberger, Daniel R., additional, Weisbrod, Matthias, additional, Weiser, Mark, additional, Werge, Thomas, additional, Weston, Paul, additional, Whittaker, Pamela, additional, Widaa, Sara, additional, Wiersma, Durk, additional, Wildenauer, Dieter B., additional, Williams, Nigel M., additional, Williams, Stephanie, additional, Witt, Stephanie H., additional, Wolen, Aaron R., additional, Wong, Emily H.M., additional, Wood, Nicholas W., additional, Wormley, Brandon K., additional, Wu, Jing Qin, additional, Xi, Simon, additional, Xu, Wei, additional, Young, Allan H., additional, Zai, Clement C., additional, Zandi, Peter, additional, Zhang, Peng, additional, Zheng, Xuebin, additional, Zimprich, Fritz, additional, Zollner, Sebastian, additional, Corvin, Aiden, additional, Fanous, Ayman H., additional, Cichon, Sven, additional, Rietschel, Marcella, additional, Gershon, Elliot S., additional, Schulze, Thomas G., additional, Cuellar-Barboza, Alfredo B., additional, Forstner, Andreas J., additional, Holmans, Peter A., additional, Nurnberger, John I., additional, Andreassen, Ole A., additional, Lee, S. Hong, additional, O’Donovan, Michael C., additional, Sullivan, Patrick F., additional, Ophoff, Roel A., additional, Wray, Naomi R., additional, Sklar, Pamela, additional, and Kendler, Kenneth S., additional

Published
2018
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49. Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A

Author

Nejentsev, Sergey, Howson, Joanna M. M., Walker, Neil M., Szeszko, Jeffrey, Field, Sarah F., Stevens, Helen E., Reynolds, Pamela, Hardy, Matthew, King, Erna, Masters, Jennifer, Hulme, John, Maier, Lisa M., Smyth, Deborah, Bailey, Rebecca, Cooper, Jason D., Ribas, Gloria, Campbell, R. Duncan, Clayton, David G., Todd, John A., Burton, Paul R., Cardon, Lon R., Craddock, Nick, Deloukas, Panos, Duncanson, Audrey, Kwiatkowski, Dominic P., McCarthy, Mark I., Ouwehand, Willem H., Samani, Nilesh J., Donnelly, Peter, Barrett, Jeffrey C., Davison, Dan, Easton, Doug, Evans, David, Leung, Hin-Tak, Marchini, Jonathan L., Morris, Andrew P., Spencer, Chris C. A., Tobin, Martin D., Attwood, Antony P., Boorman, James P., Cant, Barbara, Everson, Ursula, Hussey, Judith M., Jolley, Jennifer D., Knight, Alexandra S., Koch, Kerstin, Meech, Elizabeth, Nutland, Sarah, Prowse, Christopher V., Taylor, Niall C., Walters, Graham R., Watkins, Nicholas A., Winzer, Thilo, Jones, Richard W., McArdle, Wendy L., Ring, Susan M., Strachan, David P., Pembrey, Marcus, Breen, Gerome, St Clair, David, Caesar, Sian, Gordon-Smith, Katherine, Jones, Lisa, Fraser, Christine, Green, Elaine K., Grozeva, Detelina, Hamshere, Marian L., Holmans, Peter A., Jones, Ian R., Kirov, George, Moskvina, Valentina, Nikolov, Ivan, O'Donovan, Michael C., Owen, Michael J., Collier, David A., Elkin, Amanda, Farmer, Anne, Williamson, Richard, McGuffin, Peter, Young, Allan H., Nicol Ferrier, I., Ball, Stephen G., Balmforth, Anthony J., Barrett, Jennifer H., Bishop, D. Timothy, Iles, Mark M., Maqbool, Azhar, Yuldasheva, Nadira, Hall, Alistair S., Braund, Peter S., Dixon, Richard J., Mangino, Massimo, Stevens, Suzanne, Thompson, John R., Bredin, Francesca, Tremelling, Mark, Parkes, Miles, Drummond, Hazel, Lees, Charles W., Nimmo, Elaine R., Satsangi, Jack, Fisher, Sheila A., Forbes, Alastair, Lewis, Cathryn M., Onnie, Clive M., Prescott, Natalie J., Sanderson, Jeremy, Mathew, Christopher G., Barbour, Jamie, Khalid Mohiuddin, M., Todhunter, Catherine E., Mansfield, John C., Ahmad, Tariq, Cummings, Fraser R., Jewell, Derek P., Webster, John, Brown, Morris J., Lathrop, G. Mark, Connell, John, Dominiczak, Anna, Braga, Carolina A., Burke, Beverley, Dobson, Richard, Gungadoo, Johannie, Lee, Kate L., Munroe, Patricia B., Newhouse, Stephen J., Onipinla, Abiodun, Wallace, Chris, Xue, Mingzhan, Caulfield, Mark, Farrall, Martin, Barton, Anne, Bruce, Ian N., Donovan, Hannah, Eyre, Steve, Gilbert, Paul D., Hider, Samantha L., Hinks, Anne M., John, Sally L., Potter, Catherine, Silman, Alan J., Symmons, Deborah P. M., Thomson, Wendy, Worthington, Jane, Dunger, David B., Widmer, Barry, Frayling, Timothy M., Freathy, Rachel M., Lango, Hana, Perry, John R. B., Shields, Beverley M., Weedon, Michael N., Hattersley, Andrew T., Hitman, Graham A., Walker, Mark, Elliott, Kate S., Groves, Christopher J., Lindgren, Cecilia M., Rayner, Nigel W., Timpson, Nicholas J., Zeggini, Eleftheria, Newport, Melanie, Sirugo, Giorgio, Lyons, Emily, Vannberg, Fredrik, Hill, Adrian V. S., Bradbury, Linda A., Farrar, Claire, Pointon, Jennifer J., Wordsworth, Paul, Brown, Matthew A., Franklyn, Jayne A., Heward, Joanne M., Simmonds, Matthew J., Gough, Stephen C. L., Seal, Sheila, Stratton, Michael R., Rahman, Nazneen, Ban, Maria, Goris, An, Sawcer, Stephen J., Compston, Alastair, Conway, David, Jallow, Muminatou, Rockett, Kirk A., Bryan, Claire, Bumpstead, Suzannah J., Chaney, Amy, Downes, Kate, Ghori, Jilur, Gwilliam, Rhian, Hunt, Sarah E., Inouye, Michael, Keniry, Andrew, King, Emma, McGinnis, Ralph, Potter, Simon, Ravindrarajah, Rathi, Whittaker, Pamela, Withers, David, Cardin, Niall J., Ferreira, Teresa, Pereira-Gale, Joanne, Hallgrimsdottir, Ingeleif B., Howie, Bryan N., Su, Zhan, Ying Teo, Yik, Vukcevic, Damjan, Bentley, David, and Compston, Alistair

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Sergey Nejentsev [1, 57]; Joanna M. M. Howson (corresponding author) [1, 57]; Neil M. Walker [1]; Jeffrey Szeszko [1]; Sarah F. Field [1]; Helen E. Stevens [1]; Pamela Reynolds [...]

Published
2007
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50. Genome-wide association study identifies 30 Loci Associated with Bipolar Disorder

Author

Stahl, Eli A, primary, Breen, Gerome, additional, Forstner, Andreas J, additional, McQuillin, Andrew, additional, Ripke, Stephan, additional, Trubetskoy, Vassily, additional, Mattheisen, Manuel, additional, Wang, Yunpeng, additional, Coleman, Jonathan R I, additional, Gaspar, Héléna A, additional, de Leeuw, Christiaan A, additional, Steinberg, Stacy, additional, Whitehead Pavlides, Jennifer M, additional, Trzaskowski, Maciej, additional, Pers, Tune H, additional, Holmans, Peter A, additional, Abbott, Liam, additional, Agerbo, Esben, additional, Akil, Huda, additional, Albani, Diego, additional, Alliey-Rodriguez, Ney, additional, Als, Thomas D, additional, Anjorin, Adebayo, additional, Antilla, Verneri, additional, Awasthi, Swapnil, additional, Badner, Judith A, additional, Bækvad-Hansen, Marie, additional, Barchas, Jack D, additional, Bass, Nicholas, additional, Bauer, Michael, additional, Belliveau, Richard, additional, Bergen, Sarah E, additional, Bøcker Pedersen, Carsten, additional, Bøen, Erlend, additional, Boks, Marco, additional, Boocock, James, additional, Budde, Monika, additional, Bunney, William, additional, Burmeister, Margit, additional, Bybjerg-Grauholm, Jonas, additional, Byerley, William, additional, Casas, Miquel, additional, Cerrato, Felecia, additional, Cervantes, Pablo, additional, Chambert, Kimberly, additional, Charney, Alexander W, additional, Chen, Danfeng, additional, Churchhouse, Claire, additional, Clarke, Toni-Kim, additional, Coryell, William, additional, Craig, David W, additional, Cruceanu, Cristiana, additional, Curtis, David, additional, Czerski, Piotr M, additional, Dale, Anders M, additional, de Jong, Simone, additional, Degenhardt, Franziska, additional, Del-Favero, Jurgen, additional, DePaulo, J Raymond, additional, Djurovic, Srdjan, additional, Dobbyn, Amanda L, additional, Dumont, Ashley, additional, Elvsåshagen, Torbjørn, additional, Escott-Price, Valentina, additional, Fan, Chun Chieh, additional, Fischer, Sascha B, additional, Flickinger, Matthew, additional, Foroud, Tatiana M, additional, Forty, Liz, additional, Frank, Josef, additional, Fraser, Christine, additional, Freimer, Nelson B, additional, Frisén, Louise, additional, Gade, Katrin, additional, Gage, Diane, additional, Garnham, Julie, additional, Giambartolomei, Claudia, additional, Giørtz Pedersen, Marianne, additional, Goldstein, Jaqueline, additional, Gordon, Scott D, additional, Gordon-Smith, Katherine, additional, Green, Elaine K, additional, Green, Melissa J, additional, Greenwood, Tiffany A, additional, Grove, Jakob, additional, Guan, Weihua, additional, Parra, JoséGuzman, additional, Hamshere, Marian L, additional, Hautzinger, Martin, additional, Heilbronner, Urs, additional, Herms, Stefan, additional, Hipolito, Maria, additional, Hoffmann, Per, additional, Holland, Dominic, additional, Huckins, Laura, additional, Jamain, Stéphane, additional, Johnson, Jessica S, additional, Juréus, Anders, additional, Kandaswamy, Radhika, additional, Karlsson, Robert, additional, Kennedy, James L, additional, Kittel-Schneider, Sarah, additional, Knott, Sarah V, additional, Knowles, James A, additional, Kogevinas, Manolis, additional, Koller, Anna C, additional, Kupka, Ralph, additional, Lavebratt, Catharina, additional, Lawrence, Jacob, additional, Lawson, William B, additional, Leber, Markus, additional, Lee, Phil H, additional, Levy, Shawn E, additional, Li, Jun Z, additional, Liu, Chunyu, additional, Lucae, Susanne, additional, Maaser, Anna, additional, MacIntyre, Donald J, additional, Mahon, Pamela B, additional, Maier, Wolfgang, additional, Martinsson, Lina, additional, McCarroll, Steve, additional, McGuffin, Peter, additional, McInnis, Melvin G, additional, McKay, James D, additional, Medeiros, Helena, additional, Medland, Sarah E, additional, Meng, Fan, additional, Milani, Lili, additional, Montgomery, Grant W, additional, Morris, Derek W, additional, Mühleisen, Thomas W, additional, Mullins, Niamh, additional, Nguyen, Hoang, additional, Nievergelt, Caroline M, additional, Adolfsson, Annelie Nordin, additional, Nwulia, Evaristus A, additional, O’Donovan, Claire, additional, Olde Loohuis, Loes M, additional, Ori, Anil P S, additional, Oruc, Lilijana, additional, Ösby, Urban, additional, Perlis, Roy H, additional, Perry, Amy, additional, Pfennig, Andrea, additional, Potash, James B, additional, Purcell, Shaun M, additional, Regeer, Eline J, additional, Reif, Andreas, additional, Reinbold, Céline S, additional, Rice, John P, additional, Rivas, Fabio, additional, Rivera, Margarita, additional, Roussos, Panos, additional, Ruderfer, Douglas M, additional, Ryu, Euijung, additional, Sánchez-Mora, Cristina, additional, Schatzberg, Alan F, additional, Scheftner, William A, additional, Schork, Nicholas J, additional, Weickert, Cynthia Shannon, additional, Shehktman, Tatyana, additional, Shilling, Paul D, additional, Sigurdsson, Engilbert, additional, Slaney, Claire, additional, Smeland, Olav B, additional, Sobell, Janet L, additional, Søholm Hansen, Christine, additional, Spijker, Anne T, additional, St Clair, David, additional, Steffens, Michael, additional, Strauss, John S, additional, Streit, Fabian, additional, Strohmaier, Jana, additional, Szelinger, Szabolcs, additional, Thompson, Robert C, additional, Thorgeirsson, Thorgeir E, additional, Treutlein, Jens, additional, Vedder, Helmut, additional, Wang, Weiqing, additional, Watson, Stanley J, additional, Weickert, Thomas W, additional, Witt, Stephanie H, additional, Xi, Simon, additional, Xu, Wei, additional, Young, Allan H, additional, Zandi, Peter, additional, Zhang, Peng, additional, Zollner, Sebastian, additional, Adolfsson, Rolf, additional, Agartz, Ingrid, additional, Alda, Martin, additional, Backlund, Lena, additional, Baune, Bernhard T, additional, Bellivier, Frank, additional, Berrettini, Wade H, additional, Biernacka, Joanna M, additional, Blackwood, Douglas H R, additional, Boehnke, Michael, additional, Børglum, Anders D, additional, Corvin, Aiden, additional, Craddock, Nicholas, additional, Daly, Mark J, additional, Dannlowski, Udo, additional, Esko, Tõnu, additional, Etain, Bruno, additional, Frye, Mark, additional, Fullerton, Janice M, additional, Gershon, Elliot S, additional, Gill, Michael, additional, Goes, Fernando, additional, Grigoroiu-Serbanescu, Maria, additional, Hauser, Joanna, additional, Hougaard, David M, additional, Hultman, Christina M, additional, Jones, Ian, additional, Jones, Lisa A, additional, Kahn, RenéS, additional, Kirov, George, additional, Landén, Mikael, additional, Leboyer, Marion, additional, Lewis, Cathryn M, additional, Li, Qingqin S, additional, Lissowska, Jolanta, additional, Martin, Nicholas G, additional, Mayoral, Fermin, additional, McElroy, Susan L, additional, McIntosh, Andrew M, additional, McMahon, Francis J, additional, Melle, Ingrid, additional, Metspalu, Andres, additional, Mitchell, Philip B, additional, Morken, Gunnar, additional, Mors, Ole, additional, Mortensen, Preben Bo, additional, Müller-Myhsok, Bertram, additional, Myers, Richard M, additional, Neale, Benjamin M, additional, Nimgaonkar, Vishwajit, additional, Nordentoft, Merete, additional, Nöthen, Markus M, additional, O’Donovan, Michael C, additional, Oedegaard, Ketil J, additional, Owen, Michael J, additional, Paciga, Sara A, additional, Pato, Carlos, additional, Pato, Michele T, additional, Posthuma, Danielle, additional, Ramos-Quiroga, Josep Antoni, additional, Ribasés, Marta, additional, Rietschel, Marcella, additional, Rouleau, Guy A, additional, Schalling, Martin, additional, Schofield, Peter R, additional, Schulze, Thomas G, additional, Serretti, Alessandro, additional, Smoller, Jordan W, additional, Stefansson, Hreinn, additional, Stefansson, Kari, additional, Stordal, Eystein, additional, Sullivan, Patrick F, additional, Turecki, Gustavo, additional, Vaaler, Arne E, additional, Vieta, Eduard, additional, Vincent, John B, additional, Werge, Thomas, additional, Nurnberger, John I, additional, Wray, Naomi R, additional, Di Florio, Arianna, additional, Edenberg, Howard J, additional, Cichon, Sven, additional, Ophoff, Roel A, additional, Scott, Laura J, additional, Andreassen, Ole A, additional, Kelsoe, John, additional, and Sklar, Pamela, additional

Published
2017
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