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Your search keyword '"Fraschini, Gianfranco"' showing total 38 results
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38 results on '"Fraschini, Gianfranco"'

14. ESWT and nutraceutical supplementation (Tendisulfur Forte) vs ESWT-only in the treatment of lateral epicondylitis, Achilles tendinopathy, and rotator cuff tendinopathy: a comparative study

Author

Gaia Di Carlo, Fraschini Gianfranco, Anshuman Chawla, Pierluigi Pironti, Andreas Drossinos, Nadim Naim Rodriguez, and Matteo Vitali

Subjects
medicine.medical_specialty, Extracorporeal shockwave therapy, medicine.medical_treatment, Elbow, Dietary supplement, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Nutraceutical, medicine, Rotator cuff, tendinopathy, Achilles tendon, business.industry, Epicondylitis, elbow, medicine.disease, rotator cuff, Surgery, medicine.anatomical_structure, Orthopedic Medicine, dietary supplement, Tendinopathy, business, 030217 neurology & neurosurgery
Abstract

Objective: The purpose of this study was to determine the efficacy of Extracorporeal Shock Wave Therapy (ESWT) in combination with the dietary supplement Tendisulfur Forte in the treatment of shoulder tendinopathy, lateral epicondylitis, and Achilles tendinopathy. Methods: Patients were sub-divided for each pathology into two equal sized groups of 15: one treated with ESWT supplemented with Tendisulfur Forte, and the other treated with ESWT only. Shoulder functionality was measured through the UCLA shoulder score. Treatment of epicondylitis was assessed with the Mayo elbow score. Achilles tendinopathy was measured with the VISA-A score. Pain through the various groups of the study was measures with the Visual Analog Scale (VAS). Results: Patients in the Tendisulfur Forte group had overall better functional and VAS scale scores for shoulder tendinopathy, elbow epicondylitis, and Achilles tendinopathy. UCLA scores for shoulder tendinopathy showed significant results at 60 days in the Tendisulfur Forte group (p = 0.0002). Mayo scores in the treatment of lateral epicondylitis was significant at 60 days in the study group (p

Published
2018

16. An early‐senescence state in aged mesenchymal stromal cells contributes to hematopoietic stem and progenitor cell clonogenic impairment through the activation of a pro‐inflammatory program

Author

Gnani, Daniela, primary, Crippa, Stefania, additional, della Volpe, Lucrezia, additional, Rossella, Valeria, additional, Conti, Anastasia, additional, Lettera, Emanuele, additional, Rivis, Silvia, additional, Ometti, Marco, additional, Fraschini, Gianfranco, additional, Bernardo, Maria Ester, additional, and Di Micco, Raffaella, additional

Published
2019
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20. Composite scaffold for tissue repair

Author

Peretti, Giuseppe, Fraschini, Gianfranco, Di, GIANCAMILLO Alessia, Domeneghini, Cinzia, Deponti, Daniela Rosa, SANNINO, Alessandro, GERVASO, FRANCESCA, SCALERA, FRANCESCA, Gervaso, Francesca, Scalera, Francesca, Sannino, Alessandro, Giuseppe, Peretti, Gianfranco, Fraschini, Cinzia, Domeneghini, Alessia Di, Giancamillo, Daniela, Deponti, Peretti, Giuseppe, Fraschini, Gianfranco, Di, GIANCAMILLO Alessia, Domeneghini, Cinzia, and Deponti, Daniela Rosa

Published
2013

23. A swine model for meniscus maturation during growth

Author

Di Giancamillo, Alessia, Deponti, Daniela, Addis, Alessandro, Campagnol, Marino, Fraschini, Gianfranco, Domeneghini, Cinzia, and Peretti, Giuseppe M.

Subjects
Meniscus, swine animal model, cell phenotype, growth
Abstract

The meniscal vascular network changes during growth leading to the formation of a very heterogeneous tissue, with both a fibrous and cartilaginous matrix. This work focuses on the changes in the meniscus matrix and cell phenotype during growth. Menisci were harvested from young and adult pigs and cut into the two horns and the body. DNA and GAGs contents were determined; other samples were stained with SAFRANIN-O, for proteoglycan distribution, and contemporary stained for collagen 1 and 2; other samples were processed for collagen1 and 2 quantification by western blot analysis. Moreover, the body of each meniscus was divided into the inner, the intermediate and the external zone; each of them was processed for gene expression analysis. The obtained data showed a strong increase in GAGs production during growth as also observed by other author in cows (Ionescu et al, 2011), with an higher distribution in the inner area of the meniscus, in particular in the anterior horn; no differences were observed in the cellularity; collagen 2 deposition increased in the anterior horn during growth being confined mainly in the inner area, while collagen 1 deposition decreased being confined mainly in the external area. The analysis of the inner, intermediate and external zones showed that the intermediate one assumes a fibro-chondrocyte phenotype during growth becoming similar to the inner one. In conclusion, meniscus growth, from young to adult, is accompanied by a maturation of the anterior horn into a fibro-cartilaginous tissue; moreover, not only the whole inner but also the intermediate area of the meniscus develops fibro-cartilaginous properties during growth., Italian Journal of Anatomy and Embryology, Vol 117, No 2 (Supplement) 2012

Published
2013
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26. Metabolomics identifies plasma biomarkers of multiple myeloma development and progression

Author

Mariani, Elisabetta, primary, Fontana, Francesca, additional, Mari, Silvia, additional, Manteiga, Jose Manuel Garcia, additional, Marcatti, Magda, additional, Napoli, Nicola, additional, Camnasio, Francesco, additional, Fraschini, Gianfranco, additional, Caneva, Enrico, additional, Sitia, Roberto, additional, Musco, Giovanna, additional, Ciceri, Fabio, additional, and Cenci, Simone, additional

Published
2013
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36. Fibrin-Based Model for Cartilage Regeneration: Tissue Maturation from In Vitroto In Vivo

Author

Deponti, Daniela, Di Giancamillo, Alessia, Mangiavini, Laura, Pozzi, Alessandro, Fraschini, Gianfranco, Sosio, Corrado, Domeneghini, Cinzia, and Peretti, Giuseppe M.

Abstract

One of the crucial points for a successful tissue-engineering approach for cartilage repair is represented by the level of in vitromaturation of the engineered tissue before implantation. The purpose of this work was to evaluate the effect of the level of in vitromaturation of engineered cartilaginous samples on the tissue quality after in vivoimplantation. Samples were obtained from isolated swine articular chondrocytes embedded in fibrin glue. The cell-fibrin composites were either cultured in vitroor directly implanted in vivofor 1, 5, and 9 weeks. Other experimental samples were precultured for either 1 or 5 weeks in vitroand then implanted in vivofor 4 additional weeks. All the samples were analyzed by histology, immunohistochemistry, biochemistry, and gene expression. The results strongly suggest that the in vivoculture in this model promoted a better tissue maturation than that obtained in the in vitrocondition, and that 1 week in vitropreculture resulted in the primary structuring of the engineered composites and their subsequent maturation in vivo, without affecting the cell viability and activity, while a prolonged in vitropreculture caused a cell and matrix degeneration that could not be rescued in vivo.

Published
2012
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37. Dupuytren's Disease: Predicting Factors and Associated Conditions. A Single Center Questionnaire-Based Case-Control Study.

Author

Morelli I, Fraschini G, and Banfi AE

Abstract

Background: Conflicting studies link several conditions and risk factors to Dupuytren's disease (DD). A questionnaire-based case-control study was set to investigate associated conditions and clinical features of DD in a sample of Italian patients. The main purpose was the identification of predicting factors for: DD development; involvement of multiple rays; involvement of both hands; development of radial DD; development of recurrences and extensions., Methods: A self-administered questionnaire was used to investigate medical and drug histories, working and life habits, DD clinical features, familial history, recurrences and extensions. Binary logistic regression, Mann Whitney U-test and Fisher's exact test were used for the statistical analysis., Results: A role in DD development was found for male sex, cigarette smoking, diabetes and heavy manual work. The development of aggressive DD has been linked to age, male sex, high alcohol intake, dyslipidemias and positive familial history., Conclusion: Further studies might explain the dual relationship between ischemic heart disease and DD. According to our results, the questionnaire used for this study revealed to be an easy-handling instrument to analyze the conditions associated to DD. Nevertheless, its use in further and larger studies is needed to confirm our results as well as the role of the questionnaire itself as investigation tool for clinical studies.

Published
2017

38. Fibrin-based model for cartilage regeneration: tissue maturation from in vitro to in vivo.

Author

Deponti D, Di Giancamillo A, Mangiavini L, Pozzi A, Fraschini G, Sosio C, Domeneghini C, and Peretti GM

Subjects
Animals, Blotting, Western, Collagen Type I metabolism, Collagen Type II metabolism, DNA metabolism, Fluorescent Antibody Technique, Gene Expression Regulation drug effects, Glycosaminoglycans metabolism, Mice, Mice, Nude, Staining and Labeling, Sus scrofa, Cartilage, Articular drug effects, Cartilage, Articular physiology, Fibrin pharmacology, Models, Biological, Regeneration drug effects, Tissue Engineering methods
Abstract

One of the crucial points for a successful tissue-engineering approach for cartilage repair is represented by the level of in vitro maturation of the engineered tissue before implantation. The purpose of this work was to evaluate the effect of the level of in vitro maturation of engineered cartilaginous samples on the tissue quality after in vivo implantation. Samples were obtained from isolated swine articular chondrocytes embedded in fibrin glue. The cell-fibrin composites were either cultured in vitro or directly implanted in vivo for 1, 5, and 9 weeks. Other experimental samples were precultured for either 1 or 5 weeks in vitro and then implanted in vivo for 4 additional weeks. All the samples were analyzed by histology, immunohistochemistry, biochemistry, and gene expression. The results strongly suggest that the in vivo culture in this model promoted a better tissue maturation than that obtained in the in vitro condition, and that 1 week in vitro preculture resulted in the primary structuring of the engineered composites and their subsequent maturation in vivo, without affecting the cell viability and activity, while a prolonged in vitro preculture caused a cell and matrix degeneration that could not be rescued in vivo.

Published
2012
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