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3. Lentisk (Pistacia lentiscus) Oil Nanoemulsions Loaded with Levofloxacin: Phytochemical Profiles and Antibiofilm Activity against Staphylococcus spp.

Author

Maurizi, Linda, Lasalvia, Alba, Fabiano, Maria Gioia, D'Intino, Eleonora, Del Cioppo, Francesca, Fraschetti, Caterina, Filippi, Antonello, Ammendolia, Maria Grazia, Conte, Antonietta Lucia, Forte, Jacopo, Corinti, Davide, Crestoni, Maria Elisa, Carafa, Maria, Marianecci, Carlotta, Rinaldi, Federica, and Longhi, Catia

Subjects
ION cyclotron resonance spectrometry, STAPHYLOCOCCUS epidermidis, STAPHYLOCOCCUS aureus, DRUG delivery systems, SKIN infections
Abstract

Most clinical isolates of both Staphylococcus aureus and Staphylococcus epidermidis show the capacity to adhere to abiotic surfaces and to develop biofilms resulting in a contribution to chronic human skin infections. Antibiotic resistance and poor biofilm penetration are the main causes of ineffective therapeutic treatment in killing bacteria within biofilms. A possible strategy could be represented by drug delivery systems, such as nanoemulsions (composed of bioactive oil, surfactant and water phase), which are useful for enhancing the drug permeation of a loaded drug inside the biofilm and its activity. Phytochemical characterization of Pistacia lentiscus oil (LO) by direct infusion Fourier-transform ion cyclotron resonance mass spectrometry (FT-ICR MS) allowed the identification of bioactive compounds with antimicrobial properties, including fatty acids and phenolic compounds. Several monoterpenes and sesquiterpenes have been also detected and confirmed by gas chromatography–mass spectrometric (GC-MS) analysis, together providing a complete metabolomic profiling of LO. In the present study, a nanoemulsion composed of LO has been employed for improving Levofloxacin water solubility. A deep physical–chemical characterization of the nanoemulsion including hydrodynamic diameter, ζ-potential, morphology, entrapment efficiency, stability release and permeation studies was performed. Additionally, the antimicrobial/antibiofilm activity of these preparations was evaluated against reference and clinical Staphylococcus spp. strains. In comparison to the free-form antibiotic, the loaded NE nanocarriers exhibited enhanced antimicrobial activity against the sessile forms of Staphylococcus spp. strains. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Chemical Composition and Anti-Candida Activity of Mentha suaveolens Ehrh. Essential Oils Obtained by Different Distillation Processes

Author

Tadić, Vanja, primary, Božović, Mijat, additional, Sapienza, Filippo, additional, Astolfi, Roberta, additional, Mladenović, Milan, additional, Zaka, Maria Cristina, additional, Del Bove, Fabiana, additional, Borzacchi, Francesca, additional, Fraschetti, Caterina, additional, Rossi, Caterina, additional, Vertuani, Silvia, additional, Baldisserotto, Anna, additional, Manfredini, Stefano, additional, and Ragno, Rino, additional

Published
2023
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7. Effect of Different Soil Treatments on Production and Chemical Composition of Essential Oils Extracted from Foeniculum vulgare Mill., Origanum vulgare L. and Thymus vulgaris L.

Author

Raffo, Antonio, primary, Sapienza, Filippo Umberto, additional, Astolfi, Roberta, additional, Lombardi, Gabriele, additional, Fraschetti, Caterina, additional, Božović, Mijat, additional, Artini, Marco, additional, Papa, Rosanna, additional, Trecca, Marika, additional, Fiorentino, Simona, additional, Vecchiarelli, Valerio, additional, Papalini, Claudia, additional, Selan, Laura, additional, and Ragno, Rino, additional

Published
2023
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8. First-in-Class Selective Inhibitors of the Lysine Acetyltransferase KAT8

Author

Fiorentino, Francesco, primary, Sementilli, Sara, additional, Menna, Martina, additional, Turrisi, Federica, additional, Tomassi, Stefano, additional, Pellegrini, Francesca Romana, additional, Iuzzolino, Angela, additional, D’Acunzo, Francesca, additional, Feoli, Alessandra, additional, Wapenaar, Hannah, additional, Taraglio, Sophie, additional, Fraschetti, Caterina, additional, Del Bufalo, Donatella, additional, Sbardella, Gianluca, additional, Dekker, Frank J., additional, Paiardini, Alessandro, additional, Trisciuoglio, Daniela, additional, Mai, Antonello, additional, and Rotili, Dante, additional

Published
2023
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12. Anti-Inflammatory and Antioxidant Effects Induced by Allium sativum L. Extracts on an Ex Vivo Experimental Model of Ulcerative Colitis

Author

Recinella, Lucia, primary, Gorica, Era, additional, Chiavaroli, Annalisa, additional, Fraschetti, Caterina, additional, Filippi, Antonello, additional, Cesa, Stefania, additional, Cairone, Francesco, additional, Martelli, Alma, additional, Calderone, Vincenzo, additional, Veschi, Serena, additional, Lanuti, Paola, additional, Cama, Alessandro, additional, Orlando, Giustino, additional, Ferrante, Claudio, additional, Menghini, Luigi, additional, Di Simone, Simonetta Cristina, additional, Acquaviva, Alessandra, additional, Libero, Maria Loreta, additional, Nilofar, Nilofar, additional, Brunetti, Luigi, additional, and Leone, Sheila, additional

Published
2022
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23. Protective Effects Induced by a Hydroalcoholic Allium sativum Extract in Isolated Mouse Heart

Author

Recinella, Lucia, primary, Chiavaroli, Annalisa, additional, Masciulli, Fabrizio, additional, Fraschetti, Caterina, additional, Filippi, Antonello, additional, Cesa, Stefania, additional, Cairone, Francesco, additional, Gorica, Era, additional, De Leo, Marinella, additional, Braca, Alessandra, additional, Martelli, Alma, additional, Calderone, Vincenzo, additional, Orlando, Giustino, additional, Ferrante, Claudio, additional, Menghini, Luigi, additional, Di Simone, Simonetta Cristina, additional, Veschi, Serena, additional, Cama, Alessandro, additional, Brunetti, Luigi, additional, and Leone, Sheila, additional

Published
2021
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25. Chemical and Bioinformatics Analyses of the Anti-Leishmanial and Anti-Oxidant Activities of Hemp Essential Oil

Author

Menghini, Luigi, primary, Ferrante, Claudio, additional, Carradori, Simone, additional, D’Antonio, Marianna, additional, Orlando, Giustino, additional, Cairone, Francesco, additional, Cesa, Stefania, additional, Filippi, Antonello, additional, Fraschetti, Caterina, additional, Zengin, Gokhan, additional, Ak, Gunes, additional, Tacchini, Massimo, additional, and Iqbal, Kashif, additional

Published
2021
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29. Chemico-Biological Characterization of Torpedino Di Fondi® Tomato Fruits: A Comparison with San Marzano Cultivar at Two Ripeness Stages

Author

Ingallina, Cinzia, primary, Maccelli, Alessandro, additional, Spano, Mattia, additional, Di Matteo, Giacomo, additional, Di Sotto, Antonella, additional, Giusti, Anna Maria, additional, Vinci, Giuliana, additional, Di Giacomo, Silvia, additional, Rapa, Mattia, additional, Ciano, Salvatore, additional, Fraschetti, Caterina, additional, Filippi, Antonello, additional, Simonetti, Giovanna, additional, Cordeiro, Carlos, additional, Silva, Marta Sousa, additional, Crestoni, Maria Elisa, additional, Sobolev, Anatoly P., additional, Fornarini, Simonetta, additional, and Mannina, Luisa, additional

Published
2020
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30. Cannabis sativa L. Inflorescences from Monoecious Cultivars Grown in Central Italy: An Untargeted Chemical Characterization from Early Flowering to Ripening

Author

Ingallina, Cinzia, primary, Sobolev, Anatoly P., additional, Circi, Simone, additional, Spano, Mattia, additional, Fraschetti, Caterina, additional, Filippi, Antonello, additional, Di Sotto, Antonella, additional, Di Giacomo, Silvia, additional, Mazzoccanti, Giulia, additional, Gasparrini, Francesco, additional, Quaglio, Deborah, additional, Campiglia, Enio, additional, Carradori, Simone, additional, Locatelli, Marcello, additional, Vinci, Giuliana, additional, Rapa, Mattia, additional, Ciano, Salvatore, additional, Giusti, Anna Maria, additional, Botta, Bruno, additional, Ghirga, Francesca, additional, Capitani, Donatella, additional, and Mannina, Luisa, additional

Published
2020
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31. Phytochemical and biological characterization of Italian “sedano bianco di Sperlonga” Protected Geographical Indication celery ecotype: A multimethodological approach

Author

Ingallina, Cinzia, primary, Capitani, Donatella, additional, Mannina, Luisa, additional, Carradori, Simone, additional, Locatelli, Marcello, additional, Di Sotto, Antonella, additional, Di Giacomo, Silvia, additional, Toniolo, Chiara, additional, Pasqua, Gabriella, additional, Valletta, Alessio, additional, Simonetti, Giovanna, additional, Parroni, Alessia, additional, Beccaccioli, Marzia, additional, Vinci, Giuliana, additional, Rapa, Mattia, additional, Giusti, Anna Maria, additional, Fraschetti, Caterina, additional, Filippi, Antonello, additional, Maccelli, Alessandro, additional, Crestoni, Maria Elisa, additional, Fornarini, Simonetta, additional, and Sobolev, Anatoly P., additional

Published
2020
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32. Satureja montana L. Essential Oils: Chemical Profiles/Phytochemical Screening, Antimicrobial Activity and O/W NanoEmulsion Formulations

Author

Maccelli, Alessandro, primary, Vitanza, Luca, additional, Imbriano, Anna, additional, Fraschetti, Caterina, additional, Filippi, Antonello, additional, Goldoni, Paola, additional, Maurizi, Linda, additional, Ammendolia, Maria Grazia, additional, Crestoni, Maria Elisa, additional, Fornarini, Simonetta, additional, Menghini, Luigi, additional, Carafa, Maria, additional, Marianecci, Carlotta, additional, Longhi, Catia, additional, and Rinaldi, Federica, additional

Published
2019
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33. Binding Motifs in the Naked Complexes of Target Amino Acids with an Excerpt of Antitumor Active Biomolecule: An Ion Vibrational Spectroscopy Assay.

Author

Chiavarino, Barbara, Sinha, Rajeev K., Crestoni, Maria Elisa, Corinti, Davide, Filippi, Antonello, Fraschetti, Caterina, Scuderi, Debora, Maitre, Philippe, and Fornarini, Simonetta

Subjects
AMINO acids, MASS spectrometry, HISTIDINE, SPECTROMETRY, SMALL molecules, IONS
Abstract

The structures of proton‐bound complexes of 5,7‐dimethoxy‐4H‐chromen‐4‐one (1) and basic amino acids (AAs), namely, histidine (His) and lysine (Lys), have been examined by means of mass spectrometry coupled with IR ion spectroscopy and quantum chemical calculations. This selection of systems is based on the fact that 1 represents a portion of glabrescione B, a natural small molecule of promising antitumor activity, while His and Lys are protein residues lining the cavity of the alleged receptor binding site. These species are thus a model of the bioactive adduct, although clearly the isolated state of the present study bears little resemblance to the complex biological environment. A common feature of [1+AA+H]+ complexes is the presence of a protonated AA bound to neutral 1, in spite of the fact that the gas‐phase basicity of 1 is comparable to those of Lys and His. The carbonyl group of 1 acts as a powerful hydrogen‐bond acceptor. Within [1+AA+H]+ the side‐chain substituents (imidazole group for His and terminal amino group for Lys) present comparable basic properties to those of the α‐amino group, taking part to a cooperative hydrogen‐bond network. Structural assignment, relying on the comparative analysis of the infrared multiple photon dissociation (IRMPD) spectrum and calculated IR spectra for the candidate geometries, derives from an examination over two frequency ranges: 900–1800 and 2900–3700 cm−1. Information gained from the latter one proved especially valuable, for example, pointing to the contribution of species characterized by an unperturbed carboxylic OH or imidazole NH stretching mode. [ABSTRACT FROM AUTHOR]

Published
2021
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34. Effect of Satureja montana L. (Lamiaceae) essential oil based nanoemulsions against avian Escherichia coli strains

Author

Vitanza, Luca, Ammendolia, Maria Grazia, Maurizi, Linda, Comanducci, Antonella, Goldoni, Paola, Rinaldi, Federica, Hanieh, PATRIZIA NADIA, Crestoni, Maria Elisa, Fraschetti, Caterina, Scazzocchio, Francesca, and Longhi, Catia

Subjects
nanoemulsions, Essential oils, Essential oils, nanoemulsions, bactericidal and bacteriostatic effect, bactericidal and bacteriostatic effect
Published
2018

35. Chromatographic Analyses, In Vitro Biological Activities, and Cytotoxicity of Cannabis sativa L. Essential Oil: A Multidisciplinary Study

Author

Zengin, Gokhan, primary, Menghini, Luigi, additional, Di Sotto, Antonella, additional, Mancinelli, Romina, additional, Sisto, Francesca, additional, Carradori, Simone, additional, Cesa, Stefania, additional, Fraschetti, Caterina, additional, Filippi, Antonello, additional, Angiolella, Letizia, additional, Locatelli, Marcello, additional, Mannina, Luisa, additional, Ingallina, Cinzia, additional, Puca, Valentina, additional, D’Antonio, Marianna, additional, and Grande, Rossella, additional

Published
2018
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38. Gas-phase diastereoselectivity of secondary 5-substituted (X)-adamant-2-yl (X = F, Si[(C[H.sub.3]).sub.3]) cations

Author

Fraschetti, Caterina, Novara, Francesca R., Filippi, Antonello, Trout, Neil A., Adcock, William, Sorensen, Ted S., and Speranza, Maurizio

Subjects
Silicon compounds -- Electric properties, Diastereomers -- Analysis, Carbon compounds -- Electric properties, Biological sciences, Chemistry
Abstract

The investigation report of secondary 5-X-adamant-2-yl cations [I.sub.x] (X = F, Si[(C[H.sub.3]).sub.3] generated in the gas phase from protonation-induced defluorination of epimeric 2-F-5-X-adamantanes [I.sub.x] and their kinetic diastereoselectivity toward C[H.sub.3.sup.18]OH in the temperature range 40-160 degree Celsius is presented.

Published
2007

42. Coriander (Coriandrum sativum) Essential Oil: Effect on Multidrug Resistant UropathogenicEscherichia coli

Author

Scazzocchio, Francesca, primary, Mondì, Lorenzo, additional, Ammendolia, Maria Grazia, additional, Goldoni, Paola, additional, Comanducci, Antonella, additional, Marazzato, Massimiliano, additional, Conte, Maria Pia, additional, Rinaldi, Federica, additional, Crestoni, Maria Elisa, additional, Fraschetti, Caterina, additional, and Longhi, Catia, additional

Published
2017
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45. Role of the solvent on the stability of cycloserine under ESI-MS conditions

Author

Fraschetti, Caterina, Filippi, Antonello, Mannina, Luisa, Sobolev, A. P., and Speranza, Maurizio

Subjects
Spectrometry, Mass, Electrospray Ionization, Acetonitriles, Magnetic Resonance Spectroscopy, dimerization, NMR spectroscopy, Drug Stability, IRMPD spectroscopy, Methanol, Solvents, solvent effects, cycloserine, dimerization, IRMPD spectroscopy, NMR spectroscopy, solvent effects, cycloserine
Abstract

The effects of methanol (M) and acetonitrile (A) on the stability of cycloserine (1) have been studied. InfraRed Multiphoton PhotoDissociation (IRMPD) spectroscopy of the ionic species from electrospray ionization tandem mass spectrometry (ESI-MS) of 1/M and 1/A solutions points to extensive dimerization of 1 to cis-3,6-bis(aminooxymethyl)-2,5-piperidinedione (2), while the same process is not observed in the ESI-MS of 1/M solutions. 1D and 2D nuclear magnetic resonance experiments confirmed these findings by showing that partial dimerization of 1 actually takes place at room temperature in acetonitrile even before ESI-MS analysis. Comparison of nuclear magnetic resonance and IRMPD spectroscopic data from the same 1/A solution suggests that dimerization of cycloserine is enhanced in the ESI source.

Published
2014
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47. Cyclochiral resorcin[4]arenes as effective enantioselectors in the gas phase

Author

Fraschetti, Caterina, Letzel, M. C., Paletta, M., Mattay, J., Speranza, Maurizio, Filippi, Antonello, Aschi, M., and Rozhenko, A. B.

Subjects
Models, Molecular, Spectrometry, Mass, Electrospray Ionization, Macrocyclic Compounds, Fourier Analysis, Phenylalanine, enantiodiscrimination, resorc[4]arene, Stereoisomerism, Kinetics, ligand exchange, cyclochirality, inherent chirality, supramolecularcomplex, supramolecular complex, gas phase, FT-ICR, Gases, Calixarenes
Abstract

The effect of cyclochirality of rccc-2,8,14,20-tetra-n-decyl-4,10,16,22-tetra-O-methylresorcin[4]arene (C) on the enantiodiscrimination of a number of chiral bidentate and tridentate aromatic and aliphatic biomolecules (G) has been investigated by nano-electrospray ionization (nano-ESI)-Fourier transform ion cyclotron resonance mass spectrometry. The experimental approach is based on the formation of diastereomeric proton-bound [C center dot H center dot G](+) complexes by nano-ESI of solutions containing an equimolar amount of quasi-enantiomers (C) together with the chiral guest (G) and the subsequent measurement of the rate of the G substitution by the attack of several achiral and chiral amines. In general, the heterochiral complexes react faster than the homochiral ones, except when G is an aminoalcoholic neurotransmitter whose complexes, beyond that, exhibit the highest enantioselectivity. The kinetic results were further supported by both collision-induced dissociation experiments on some of the relevant [C-2 center dot H center dot G](+) three-body species and Density functional theory (DFT) calculations performed on the most selective systems. Copyright (C) 2012 John Wiley & Sons, Ltd.

Published
2012

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