Search

Your search keyword '"Frasca, Graziella"' showing total 147 results
Start Over Author "Frasca, Graziella"
147 results on '"Frasca, Graziella"'

8. Anthropometry, physical activity and hip fractures in the elderly

Author

Benetou, Vassiliki, Orfanos, Philippos, Benetos, Ioannis S., Pala, Valeria, Evangelista, Alberto, Frasca, Graziella, Giurdanella, Maria Concetta, Peeters, Petra H.M., van der Schouw, Yvonne T., Rohrmann, Sabine, Linseisen, Jakob, Boeing, Heiner, Weikert, Cornelia, Pettersson, Ulrika, Van Guelpen, Bethany, Bueno-de-Mesquita, H. Bas, Altzibar, Jone, Boffetta, Paolo, and Trichopoulou, Antonia

Published
2011
Full Text
View/download PDF

10. Differentially methylated microRNAs in prediagnostic samples of subjects who developed breast cancer in the European Prospective Investigation into Nutrition and Cancer (EPIC-Italy) cohort

Author

Cordero, Francesca, Ferrero, Giulio, Polidoro, Silvia, Fiorito, Giovanni, Campanella, Gianluca, Sacerdote, Carlotta, Mattiello, Amalia, Masala, Giovanna, Agnoli, Claudia, Frasca, Graziella, Panico, Salvatore, Palli, Domenico, Krogh, Vittorio, Tumino, Rosario, Vineis, Paolo, and Naccarati, Alessio

Published
2015
Full Text
View/download PDF

12. Associations between dietary pattern and lifestyle, anthropometry and other health indicators in the elderly participants of the EPIC-Italy cohort

Author

Pala, Valeria, Sieri, Sabina, Masala, Giovanna, Palli, Domenico, Panico, Salvatore, Vineis, Paolo, Sacerdote, Carlotta, Mattiello, Amalia, Galasso, Rocco, Salvini, Simonetta, Ceroti, Marco, Berrino, Franco, Fusconi, Elisabetta, Tumino, Rosario, Frasca, Graziella, Riboli, Elio, Trichopoulou, Antonia, Baibas, Nikolaos, and Krogh, Vittorio

Published
2006
Full Text
View/download PDF

15. Menace, valeurs intériorisées, contexte normatif et feedback : la justification, l'alibi subtil pour la discrimination

Author

Frasca, Graziella and Falomir Pichastor, Juan Manuel

Subjects
ddc:150
Abstract

La présente étude a pour objectif d'identifier et d'examiner les facteurs psychosociaux expliquant la persistance de la discrimination des minorités malgré sa prohibition. Plus spécifiquement, elle vise à étayer l'hypothèse selon laquelle le processus dit de « suppression » - soit une motivation élevée et une norme égalitaire prédisant une diminution de la discrimination- prendra le dessus lorsque « la justification » est faible - soit une menace faible et un feedback discriminateur, mais pas lorsque cette dernière est forte (Crandall & Eshleman, 2003). Dans cette perspective, une étude expérimentale a été réalisée auprès de 101 Suisses afin de mesurer leur attitude envers les ressortissants de l'ex-Yougoslavie vivant sur le territoire helvétique...

Published
2017

16. Abdominal adiposity is not a mediator of the protective effect of Mediterranean diet on colorectal cancer

Author

Fasanelli, Francesca, primary, Zugna, Daniela, additional, Giraudo, Maria Teresa, additional, Krogh, Vittorio, additional, Grioni, Sara, additional, Panico, Salvatore, additional, Mattiello, Amalia, additional, Masala, Giovanna, additional, Caini, Saverio, additional, Tumino, Rosario, additional, Frasca, Graziella, additional, Sciannameo, Veronica, additional, Ricceri, Fulvio, additional, and Sacerdote, Carlotta, additional

Published
2017
Full Text
View/download PDF

17. Epigenome-wide study in prediagnostic samples from the European Prospective Investigation into Nutrition and Cancer (EPIC-Italy) cohort: Differentially methylated microRNAs in subjects who developed breast cancer

Author

Naccarati, Alessio, Polidoro, Silvia, Fiorito, Giovanni, Cordero, Francesca, Ferrero, Giulio, Campanella, Gianluca, Sacerdote, Carlotta, Mattiello, Amalia, Panico, Salvatore, Masala, Giovanna, Palli, Domenico, Agnoli, Claudia, Krogh, Vittorio, Frasca, Graziella, Tumino, Rosario, and Vineis, Paolo

Published
2015

18. Additional file 1: of Gene-specific DNA methylation profiles and LINE-1 hypomethylation are associated with myocardial infarction risk

Author

Guarrera, Simonetta, Fiorito, Giovanni, N. Onland-Moret, Russo, Alessia, Agnoli, Claudia, Allione, Alessandra, Gaetano, Cornelia Di, Mattiello, Amalia, Ricceri, Fulvio, Chiodini, Paolo, Polidoro, Silvia, Frasca, Graziella, Verschuren, Monique, Boer, Jolanda, Iacoviello, Licia, Schouw, Yvonne Van Der, Tumino, Rosario, Vineis, Paolo, Krogh, Vittorio, Panico, Salvatore, Sacerdote, Carlotta, and Matullo, Giuseppe

Abstract

Supplementary methods. A document with supplementary materials, including the following: (1) subjects: cohort details; lifestyle, anthropometrics, and biochemical measurements; and outcome definition; (2) laboratory methods: EPICOR sample preparation; discovery phase: Illumina Human450K Methylation Assay; replication phase on EPIC-NL sample: Sequenom MassARRAY; and (3) supplementary statistical methods: case-control differential methylation; removal of technical biases; DNA methylation and MI risk; DNA methylation and time to disease (TTD); supplementary references. (DOCX 73 kb)

Published
2015
Full Text
View/download PDF

19. Additional file 2: of Gene-specific DNA methylation profiles and LINE-1 hypomethylation are associated with myocardial infarction risk

Author

Guarrera, Simonetta, Fiorito, Giovanni, N. Onland-Moret, Russo, Alessia, Agnoli, Claudia, Allione, Alessandra, Gaetano, Cornelia Di, Mattiello, Amalia, Ricceri, Fulvio, Chiodini, Paolo, Polidoro, Silvia, Frasca, Graziella, Verschuren, Monique, Boer, Jolanda, Iacoviello, Licia, Schouw, Yvonne Van Der, Tumino, Rosario, Vineis, Paolo, Krogh, Vittorio, Panico, Salvatore, Sacerdote, Carlotta, and Matullo, Giuseppe

Abstract

Supplemental Tables S1, S2, S3, and S4. Table S1. top 6 genic DMRs in EPICOR MI overall cases vs controls. Table S2A. details of the ZBTB12-DMR CpGs in EPICOR subjects. Table S2B. details of the ZBTB12-DMR CpGs in EPIC-NL subjects. Table S3A. EPIC-NL MI risk, adjusted models. Table S3B. EPICOR, adjusted models. Table S4A. EPICOR case-control differential methylation analysis: comparison of models with and without lipids adjustment. Table S4B. EPIC-NL case-control differential methylation analysis: comparison of models with and without lipids, batch, and WBCs adjustments. (DOCX 55 kb)

Published
2015
Full Text
View/download PDF

20. Up to one-third of breast cancer cases in post-menopausal Mediterranean women might be avoided by modifying lifestyle habits: the EPIC Italy study

Author

Masala, Giovanna, primary, Bendinelli, Benedetta, additional, Assedi, Melania, additional, Occhini, Daniela, additional, Zanna, Ines, additional, Sieri, Sabina, additional, Agnoli, Claudia, additional, Sacerdote, Carlotta, additional, Ricceri, Fulvio, additional, Mattiello, Amalia, additional, Panico, Salvatore, additional, Tumino, Rosario, additional, Frasca, Graziella, additional, Saieva, Calogero, additional, and Palli, Domenico, additional

Published
2016
Full Text
View/download PDF

21. The Association between Educational Level and Cardiovascular and Cerebrovascular Diseases within the EPICOR Study: New Evidence for an Old Inequality Problem

Author

Ricceri, Fulvio, primary, Sacerdote, Carlotta, additional, Giraudo, Maria Teresa, additional, Fasanelli, Francesca, additional, Lenzo, Giulia, additional, Galli, Matteo, additional, Sieri, Sabina, additional, Pala, Valeria, additional, Masala, Giovanna, additional, Bendinelli, Benedetta, additional, Tumino, Rosario, additional, Frasca, Graziella, additional, Chiodini, Paolo, additional, Mattiello, Amalia, additional, and Panico, Salvatore, additional

Published
2016
Full Text
View/download PDF

23. Italian cancer figures, report 2011: Survival of cancer patients in Italy

Author

Airtum, Working Group, Fusco, Mario, Buzzoni, Carlotta, Coviello, Enzo, Rashid, Ivan, Bianconi, Fortunato, Cuccaro, Francesco, Castaing, Marine, Angelis, Roberta, Giacomin, Adriano, Guzzinati, Stefano, Mosso, Maria Luisa, Pisani, Paola, Quaglia, Alberto, Randi, Giorgia, Ramazzotti, Valerio, Russo, Antonio, Senatore, Gennaro, Stracci, Fabrizio, Traina, Adele, Vercelli, Marina, Zarcone, Maurizio, Ferretti, Stefano, Mazzoleni, Guido, Bellu, Francesco, Tschugguel, Birgit, Valiere, Elena, Facchinelli, Gerlinde, Falk, Markus, Dal Cappello, Tomas, Vercellino, Pier Carlo, Andreone, Simona, Busato, Anna, Marzola, Laura, Migliari, Elena, Carletti, Nada, Nenci, Italo, Crocetti, Emanuele, Caldarella, Adele, Corbinelli, Antonella, Giusti, Francesco, Intrieri, Teresa, Manneschi, Gianfranco, Nemcova, Libuse, Romeo, Gianpaolo, Sacchettini, Claudio, Zappa, Marco, Paci, Eugenio, Serraino, Diego, Angelin, Tiziana, Bidoli, Ettore, Dal Maso, Luigino, Dottori, Margherita, Paoli, Angela, Santis, Emilia, Forgiarini, Ornella, Lise, Mauro, Zucchetto, Antonella, Zanier, Loris, Orengo, Maria Antonietta, Casella, Claudia, Marani, Enza, Puppo, Antonella, Celesia, Maria Vittoria, Cogno, Roberta, Manenti, Simone, Garrone, Elsa, Pannozzo, Fabio, Busco, Susanna, Maria Cecilia Cercato, Battisti, Walter, Sperduti, Isabella, Macci, Leonarda, Bugliarello, Ester, Bernazza, Edvige, Tamburo, Lucilla, Rossi, Miriana, Curatella, Simonetta, Francesco, Carla, Tamburrino, Silvana, Bisanti, Luigi, Autelitano, Mariangela, Ghilardi, Simona, Leone, Rosanna, Filipazzi, Luisa, Bonini, Annamaria, Giubelli, Cinzia, Federico, Massimo, Artioli, Maria Elisa, Valla, Katia, Braghiroli, Barbara, Cirilli, Claudia, Luminari, Stefano, Pirani, Monica, Ferrari, Lorenza, Bellatalla, Caterina, Fusco, Maria, Panico, Margherita, Perrotta, Carmela, Vassante, Biagio, Vitale, Maria Francesca, Michiara, Maria, Bozzani, Francesco, Sgargi, Paolo, Tumino, Rosario, La Rosa, Maria Guglielmina, Cascone, Giuseppe, Frasca, Graziella, Giurdanella, Maria Concetta, Martorana, Caterina, Morana, Gabriele, Nicita, Carmela, Rollo, Patrizia Concetta, Ruggeri, Maria Grazia, Sigona, Aurora, Spata, Eugenia, Vacirca, Stefania, Mangone, Lucia, Di Felice, Enza, Pezzarossi, Annamaria, Caroli, Stefania, Pellegri, Carlotta, Vicentini, Massimo, Storchi, Cinzia, Cavuto, Silvio, Costa, Jaqueline, Falcini, Fabio, Colamartini, Americo, Bucchi, Lauro, Balducci, Chiara, Ravegnani, Mila, Vitali, Benedetta, Cordaro, Carlo, Caprara, Licia, Giuliani, Orietta, Giorgetti, Stefania, Salvatore, Silvia, Palumbo, Monica, Vattiato, Rosa, Ravaioli, Alessandra, Foca, Flavia, Rinaldi, Elisa, Mancini, Silvia, Tonelli, Chiara, Amadori, Marinella, Cremone, Luigi, Iannelli, Arturo, Zevola, Arrigo, Budroni, Mario, Cesaraccio, Rosaria, Pirino, Daniela, Carboni, Donatella, Fiori, Giovanna, Soddu, Marcella, Mameli, Gianpaolo, Mura, Francesco, Contrino, Maria Lia, Madeddu, Anselmo, Tisano, Francesco, Sciacca, Salvatore, Muni, Angela, Mizzi, Margherita, Russo, Maria, Sacco, Giorgio, Aletta, Paoletta, Colanino Ziino, Antonio, Tessandori, Roberto, Fanetti, Anna Clara, Maspero, Sergio, Annulli, Monica Lucia, Moroni, Elena, Sanoja Gonzalez, Maria Eugenia, Zanetti, Roberto, Rosso, Stefano, Patriarca, Silvia, Prandi, Rossana, Sobrato, Irene, Gilardi, Franca, Busso, Paola, Piffer, Silvano, Gentilini, Maria A., Battisti, Laura, Rizzello, Roberto, Cappelletti, Maddalena, Moser, Marilena, La Rosa, Francesco, D Alo, Daniela, Scheibel, Massimo, Costarelli, Daniela, Spano, Francesco, Rossini, Stefania, Santucci, Cinzia, Petrinelli, Anna Maria, Solimene, Clotilde, Brunori, Valerio, Crosignani, Paolo, Tagliabue, Giovanna, Contiero, Paolo, Preto, Lucia, Tittarelli, Andrea, Maghini, Anna, Codazzi, Tiziana, Frassoldi, Emanuela, Gada, Daniela, Costa, Enrica, Di Grazia, Laura, Zambon, Paola, Baracco, Maddalena, Bovo, Emanuela, Dal Cin, Antonella, Fiore, Anna Rita, Greco, Alessandra, Monetti, Daniele, Rosano, Alberto, Stocco, Carmen, Tognazzo, Sandro, Donato, Francesco, Limina, Rosa Maria, Adorni, Anna, Andreis, Paolo, Zani, Giuseppe, Piovani, Francesco, Salvi, Ornella, Puleio, Maria, Vitarelli, Susanna, Antonini, Silvia, Candela, Giuseppina, Pappalardo, Giuseppe, Scuderi, Tiziana, Lottero, Barbara, Ribaudo, Michele, Ricci, Paolo, Guarda, Linda, Gatti, Luciana, Bozzeda, Annalaura, Dall Acqua, Maria, Pironi, Vanda, Sutera Sardo, Antonella, Mazzei, Adriana, Sirianni, Nicola, Lavecchia, Anna Maria, Mancuso, Pierina, Usala, Mario, Pala, Filomena, Sini, Giovanna Maria, Pintori, Nicolina, Canu, Luisa, Demurtas, Giuliana, Doa, Nina, Ponz Leon, Maurizio, Domati, Federica, Rossi, Giuseppina, Goldoni, Carlo Alberto, Rossi, Federica, Gaetani, Carmela, Benatti, Piero, Roncucci, Luca, Di Gregorio, Carmela, Pedroni, Monica, Pezzi, Annalisa, Maffei, Stefania, Mariani, Francesco, Borsi, Enrica, Carruba, Giuseppe, Cusimano, Rosanna, Amodio, Rosalba, Dolcemascolo, Cecilia, Staiti, Rosalba, Pastore, Guido, Magnani, Corrado, Terracini, Benedetto, Cena, Tiziana, Alessi, Daniela, Baussano, Iacopo, Merletti, Franco, Maule, Milena, Macerata, Vanda, Cocchioni, Mario, Pascucci, Cristiana, Gennaro, Valerio, Lazzarotto, Anna, Benfatto, Lucia, Mazzucco, Giovanna, Montanaro, Fabio, AIRTUM Working Group: [.., Enrica Borsi, and ]

Subjects
Adult, Aged, 80 and over, Male, Adolescent, Age Factors, Infant, Newborn, Infant, Middle Aged, Survival Analysis, CANCER, Survival Rate, Young Adult, Italy, Organ Specificity, Child, Preschool, Neoplasms, Humans, Female, Registries, Child, Aged
Abstract

INTRODUCTION: population-based survival analyses are fundamental to assess the impact of public health interventions and new therapies in cancer control. This monograph updates previous reports on cancer patient survival in Italy up to the year 2007. MATERIAL AND METHODS: we extracted from the Network of Italian Cancer Registries (AIRTUM) database over 1,490,000 records of tumours diagnosed during 1990-2007 and followed up to the end of 2008, including all multiple tumours. We used the Ederer II method to estimate relative survival (RS) for 29 different types of neoplasm. Five-year relative survival rates were analysed by gender and macroarea. Trends in 5-, 10- and 15-year RS were studied by gender over six 3-year diagnostic periods, from 1990 to 2007. Conditional 5-year RS was also computed by gender and macroarea. Hybrid approaches were applied to exploit the recent survival experiences of cases diagnosed up to 2007. Adjustment for age was performed using EUROCARE weights. Additional sections describe cancer patient survival in childhood and in elderly patients and provide a comparison of cancer patient survival rates in Italy with those of other countries. RESULTS: Standardized 5-year RS for all tumours but skin in 52% for men and 61% for women. Patient survival has improved for almost all types of cancer: from 1990 to 2007 5-year RS has increased by 15% for all cancers but skin; the exceptions are some cancers with poor prognosis, where patient survival has remained basically unchanged. In males, RS was usually lower than in females, but trend analysis shows that the gap is narrowing. We also report persisting lower RS in southern Italy: 5-year RS in the South is usually from 4% to 10% lower than in the North and Centre. CONCLUSION: this study provides valuable information for all stakeholders in cancer control, both in Italy and elsewhere. Increasing survival reflects improvements in various areas of cancer control. On the other hand, delayed diagnosis and suboptimal management are consistent with the reported differences in survival within the country.

Published
2011

24. Gene-specific DNA methylation profiles and LINE-1 hypomethylation are associated with myocardial infarction risk

Author

Guarrera, Simonetta, Fiorito, Giovanni, Onland-Moret, N Charlotte, Russo, Alessia, Agnoli, Claudia, Allione, Alessandra, Di Gaetano, Cornelia, Mattiello, Amalia, Ricceri, Fulvio, Chiodini, Paolo, Polidoro, Silvia, Frasca, Graziella, Verschuren, Monique W M, Boer, Jolanda M A, Iacoviello, Licia, van der Schouw, Yvonne T, Tumino, Rosario, Vineis, Paolo, Krogh, Vittorio, Panico, Salvatore, Sacerdote, Carlotta, Matullo, Giuseppe, Guarrera, Simonetta, Fiorito, Giovanni, Onland-Moret, N Charlotte, Russo, Alessia, Agnoli, Claudia, Allione, Alessandra, Di Gaetano, Cornelia, Mattiello, Amalia, Ricceri, Fulvio, Chiodini, Paolo, Polidoro, Silvia, Frasca, Graziella, Verschuren, Monique W M, Boer, Jolanda M A, Iacoviello, Licia, van der Schouw, Yvonne T, Tumino, Rosario, Vineis, Paolo, Krogh, Vittorio, Panico, Salvatore, Sacerdote, Carlotta, and Matullo, Giuseppe

Published
2015

25. Gene-specific DNA methylation profiles and LINE-1 hypomethylation are associated with myocardial infarction risk

Author

Cardiovasculaire Epi Team 3, Circulatory Health, Cancer, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Kanker, Public Health Epidemiologie, Cardiovasculaire Epidemiologie, Guarrera, Simonetta, Fiorito, Giovanni, Onland-Moret, N Charlotte, Russo, Alessia, Agnoli, Claudia, Allione, Alessandra, Di Gaetano, Cornelia, Mattiello, Amalia, Ricceri, Fulvio, Chiodini, Paolo, Polidoro, Silvia, Frasca, Graziella, Verschuren, Monique W M, Boer, Jolanda M A, Iacoviello, Licia, van der Schouw, Yvonne T, Tumino, Rosario, Vineis, Paolo, Krogh, Vittorio, Panico, Salvatore, Sacerdote, Carlotta, Matullo, Giuseppe, Cardiovasculaire Epi Team 3, Circulatory Health, Cancer, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Kanker, Public Health Epidemiologie, Cardiovasculaire Epidemiologie, Guarrera, Simonetta, Fiorito, Giovanni, Onland-Moret, N Charlotte, Russo, Alessia, Agnoli, Claudia, Allione, Alessandra, Di Gaetano, Cornelia, Mattiello, Amalia, Ricceri, Fulvio, Chiodini, Paolo, Polidoro, Silvia, Frasca, Graziella, Verschuren, Monique W M, Boer, Jolanda M A, Iacoviello, Licia, van der Schouw, Yvonne T, Tumino, Rosario, Vineis, Paolo, Krogh, Vittorio, Panico, Salvatore, Sacerdote, Carlotta, and Matullo, Giuseppe

Published
2015

26. Gene-specific DNA methylation profiles and LINE-1 hypomethylation are associated with myocardial infarction risk

Author

Guarrera, Simonetta, primary, Fiorito, Giovanni, additional, Onland-Moret, N. Charlotte, additional, Russo, Alessia, additional, Agnoli, Claudia, additional, Allione, Alessandra, additional, Di Gaetano, Cornelia, additional, Mattiello, Amalia, additional, Ricceri, Fulvio, additional, Chiodini, Paolo, additional, Polidoro, Silvia, additional, Frasca, Graziella, additional, Verschuren, Monique W. M., additional, Boer, Jolanda M. A., additional, Iacoviello, Licia, additional, van der Schouw, Yvonne T., additional, Tumino, Rosario, additional, Vineis, Paolo, additional, Krogh, Vittorio, additional, Panico, Salvatore, additional, Sacerdote, Carlotta, additional, and Matullo, Giuseppe, additional

Published
2015
Full Text
View/download PDF

27. Dietary Total Antioxidant Capacity and Colorectal Cancer in the Italian EPIC Cohort

Author

Vece, Marilena Monica, primary, Agnoli, Claudia, additional, Grioni, Sara, additional, Sieri, Sabina, additional, Pala, Valeria, additional, Pellegrini, Nicoletta, additional, Frasca, Graziella, additional, Tumino, Rosario, additional, Mattiello, Amalia, additional, Panico, Salvatore, additional, Bendinelli, Benedetta, additional, Masala, Giovanna, additional, Ricceri, Fulvio, additional, Sacerdote, Carlotta, additional, and Krogh, Vittorio, additional

Published
2015
Full Text
View/download PDF

28. Epigenome-wide association study reveals decreased average methylation levels years before breast cancer diagnosis

Author

van Veldhoven, Karin, primary, Polidoro, Silvia, additional, Baglietto, Laura, additional, Severi, Gianluca, additional, Sacerdote, Carlotta, additional, Panico, Salvatore, additional, Mattiello, Amalia, additional, Palli, Domenico, additional, Masala, Giovanna, additional, Krogh, Vittorio, additional, Agnoli, Claudia, additional, Tumino, Rosario, additional, Frasca, Graziella, additional, Flower, Kirsty, additional, Curry, Ed, additional, Orr, Nicholas, additional, Tomczyk, Katarzyna, additional, Jones, Michael E., additional, Ashworth, Alan, additional, Swerdlow, Anthony, additional, Chadeau-Hyam, Marc, additional, Lund, Eiliv, additional, Garcia-Closas, Montserrat, additional, Sandanger, Torkjel M., additional, Flanagan, James M., additional, and Vineis, Paolo, additional

Published
2015
Full Text
View/download PDF

29. Abstract LB-188: Epigenome-wide study in prediagnostic samples from the European Prospective Investigation into Nutrition and Cancer (EPIC-Italy) cohort: Differentially methylated microRNAs in subjects who developed breast cancer

Author

Naccarati, Alessio, primary, Polidoro, Silvia, additional, Fiorito, Giovanni, additional, Cordero, Francesca, additional, Ferrero, Giulio, additional, Campanella, Gianluca, additional, Sacerdote, Carlotta, additional, Mattiello, Amalia, additional, Panico, Salvatore, additional, Masala, Giovanna, additional, Palli, Domenico, additional, Agnoli, Claudia, additional, Krogh, Vittorio, additional, Frasca, Graziella, additional, Tumino, Rosario, additional, and Vineis, Paolo, additional

Published
2015
Full Text
View/download PDF

30. Metabolic Syndrome and Breast Cancer Risk: A Case-Cohort Study Nested in a Multicentre Italian Cohort

Author

Agnoli, Claudia, primary, Grioni, Sara, additional, Sieri, Sabina, additional, Sacerdote, Carlotta, additional, Ricceri, Fulvio, additional, Tumino, Rosario, additional, Frasca, Graziella, additional, Pala, Valeria, additional, Mattiello, Amalia, additional, Chiodini, Paolo, additional, Iacoviello, Licia, additional, De Curtis, Amalia, additional, Panico, Salvatore, additional, and Krogh, Vittorio, additional

Published
2015
Full Text
View/download PDF

31. Espresso Coffee Consumption and Risk of Coronary Heart Disease in a Large Italian Cohort

Author

Grioni, Sara, primary, Agnoli, Claudia, additional, Sieri, Sabina, additional, Pala, Valeria, additional, Ricceri, Fulvio, additional, Masala, Giovanna, additional, Saieva, Calogero, additional, Panico, Salvatore, additional, Mattiello, Amalia, additional, Chiodini, Paolo, additional, Tumino, Rosario, additional, Frasca, Graziella, additional, Iacoviello, Licia, additional, de Curtis, Amalia, additional, Vineis, Paolo, additional, and Krogh, Vittorio, additional

Published
2015
Full Text
View/download PDF

32. [New incidence and mortality data. 2003-2005]

Author

Airtum, Working Group, Crocetti, Emanuele, Buzzoni, Carlotta, Serraino, Diego, Vicario, Gianni, Angelin, Tiziana, Bessega, Giuseppina, Bidoli, Ettore, Brunetti, Davide, Dottori, Margherita, Forgiarini, Ornella, French, Susan, Stanta, Giorgio, Zaina, Lucia, Zanier, Loris, Zambon, Paola, Baracco, Maddalena, Bovo, Emanuela, Dal Cin, Antonella, Fiore, Anna Rita, Greco, Alessandra, Guzzinati, Stefano, Monetti, Daniele, Rosano, Alberto, Stocco, Carmen Fiorella, Tognazzo, Sandro, Egarter-Vigl, Eduard, Bello, Francesco, Vittadello, Fabio, Bulatko, Andreas, Luthy, Monika, Facchinelli, Gerlinde, Valiere, Elena, Tschugguel, Birgit, Dorfmann, Hubert, Giacomin, Adriano, Vercellino, Pier Carlo, Andreone, Simona, Ferretti, Stefano, Marzola, Laura, Migliari, Elena, Carletti, Nada, Nenci, Italo, Vitarelli, Susanna, Antonini, Silvia, Federico, Massimo, Artioli, Maria Elisa, Cirilli, Claudia, Fracca, Antonella, Rashid, Ivan, Valla, Katia, Lisi, Vincenzo, Sgargi, Paolo, Bozzani, Francesco, Donato, Andrea, Iannelli, Arturo, Mari, Carmine, Senatore, Gennaro, Zevola, Arrigo, Abbamonte, Benedetto, Alfano, Ida An, Annunziato, Loredana, Barone, Savino, Ferrante, Assunta, Budroni, Mario, Cesaraccio, Rosaria, Pirino, Daniela, Sechi, Ornelia, Piras, Daniela, Sechi, Amelia, Oggiano, Massimiliano, Piffer, Silvano, Franchini, Silva, Gentilini, Maria A., Battisti, Laura, Cappelletti, Maddalena, Falcini, Fabio, Amadori, Dino, Balducci, Chiara, Benericetti, Elisa, Bucchi, Lauro, Caprara, Licia, Colamartini, Americo, Cordaro, Carlo, Desiderio, Franco, Fabbri, Carla, Foca, Flavia, Giorgetti, Stefania, Montanari, Emanuela, Naldi, Stefania, Nannini, Roberto, Ravaioli, Alessandra, Ravegnani, Mila, Rinaldi, Elisa, Salvatore, Silvia, Serafini, Monica, Vattiato, Rosa, Vitali, Benedetta, Pannozzo, Fabio, Busco, Susanna, Natali, Maurilio, Valerio Ramazzotti, Macci, Leonarda, Bugliarello, Ester, Bernazza, Edvige, Tamburo, Lucilla, Rossi, Miriana, Curatella, Simonetta, Sperduti, Isabella, Fusco, Mario, Bellatalla, Caterina, Fusco, Maria, Panico, Margherita, Perrotta, Carmela, Vassante, Biagio, Crosignani, Paolo, Tagliabue, Giovanna, Contiero, Paolo, Fabiano, Sabrina, Maghini, Anna, Tittarelli, Andrea, Codazzi, Tiziana, Frassoldi, Emanuela, Costa, Enrica, Nobile, Silvia, Vigano, Clotilde, Berrino, Franco, Mangone, Lucia, Pezzarossi, Annamaria, Pellegri, Carlotta, Caroli, Stefania, Valentini, Massimo, Cavuto, Silvio, Felice, Enza, Vercelli, Marina, Orengo, Maria Antonietta, Casella, Claudia, Marani, Enza, Puppo, Antonella, Celesia, Maria Vittoria, Cogno, Roberta, Grondona, Anna Maria, Giachero, Giovanna, Manenti, Simone, Quaglia, Alberto, Garrone, Elsa, Paci, Eugenio, Caldarella, Adele, Corbinelli, Antonella, Dainelli, Giulia, Guadagni, Marzia, Intrieri, Teresa, Manneschi, Gianfranco, Miccinesi, Guido, Nemcova, Libuse, Sacchettini, Claudio, Giusti, Francesco, La Rosa, Francesco, Stracci, Fabrizio, Petrinelli, Anna Maria, Costarelli, Daniela, Cassetti, Tiziana, Scheibel, Massimo, Romagnoli, Carlo, Mastrandrea, Vito, Zanetti, Roberto, Rosso, Stefano, Patriarca, Silvia, Vicari, Piera, Sobrato, Irene, Gilardi, Franca, Maglietta, Giusy, Gallesio, Luisa, Tumino, Rosario, Cilia, Sonia, La Rosa, Maria Guglielmina, Cascone, Giuseppe, Cianciolo, Giuseppe, Frasca, Graziella, Giurdanella, Maria Concetta, Martorana, Caterina, Morana, Gabriele, Nicita, Carmela, Rollo, Patrizia, Ruggeri, Maria Grazia, Sigona, Aurora, Spata, Eugenia, Vacirca, Stefania, Bisanti, Luigi, Autelitano, Mariangela, Ghilardi, Simona, Bovini, Annamaria, Giubelli, Cinzia, Tessandori, Roberto, Ardemagni, Giuseppina, Traina, Adele, Candela, Pina, Contrino, Maria Lia, Tisano, Francesco, Madeddu, Anselmo, Ponz Leon, Maurizio, Di Gregorio, Carmela, Roncucci, Luca, Benfatti, Piero, Losi, Lorena, Ponti, Giovanni, Pedroni, Monica, Rossi, Giuseppina, Roncari, Barbara, Maffei, Stefania, Menigatti, Mirco, Rossi, Federica, Pecone, Luana, Domati, Federica, Pastore, Guido, Magnani, Corrado, Terracini, Benedetto, Alessi, Daniela, Dal Masso, Paola, Dama, Elisa, Macerata, Vanda, Maule, Milena, Mosso, Maria Luisa, Nonnato, Marinella, Zuccolo, Luisa, Merletti, Franco, Pannelli, Franco, Pascucci, Cristiana, Gennaro, Valerio, Benfatto, Lucia, Bianchelli, Monica, Lazzarotto, Anna, and Viarengo, Paolo

Subjects
Male, colorectal tumors, Italy, Incidence, Neoplasms, mortality, incidence, Prevalence, Humans, Female
Abstract

This is an update of incidence and mortality cancer data provided by the Italian Network of Cancer Registry (AIRTUM) relative to the period 2003-2005.AIRTUM is a network of general and specialized population-based cancer registries that covers about 1/3 of the Italian resident population (www.registri-tumori.it). Incidence and mortality data for the period 2003-2005 are based on 20 Registries. The five most frequently diagnosed cancers were: - prostate (18.5%), non melanoma skin (15.8%), lung (13.1%), colorectal (12.0%), bladder (5.7%) among males; - breast (24.9%), non melanoma skin (15.1%), colorectal (11.9%), lung (5.0%) and stomach (4.1%) among females. In the same period the most frequent causes of cancer death were: - cancer of the lung (27.6%), colorectal (10.7%), prostate (8.5%), stomach (7.3%) and liver (6.1%) among males; - breast cancer (16.3%), colorectal (11.9%), lung (10.3%), stomach (7.2%) and pancreas (6.5%) among females. According to the age-specific incidence rates one man and one woman every two will receive a cancer diagnosis during his/hers life (from birth to the age of 84 years). From 1993-1995 to 2003-2005, overall crude cancer incidence rate (males and females together) increased from 555.4 to 654.8 x 100,000. Standardization showed that 63% of this increase was due to ageing of the population. Moreover, most of the residual increase was among those cancer sites (breast, prostate, colorectal, thyroid and melanoma) for which early detection may have played a relevant role in anticipating (and therefore increasing) the number of diagnoses. Due to population ageing also overall cancer mortality did not show any decrease when crude rates were compared. On the contrary, standardized mortality rates (all cancers together) showed a strong decrease (311.4 vs. 266.5 x 100.000). The risk of receiving a diagnosis or dying because of cancer is still lower in residents in the regions of the South of Italy than in those of Central and Northern Italy, but they are becoming more and more similar. In Italy cancer incidence and mortality rates are similar to those in northern European countries and in USA among males, but they are still lower for women.

Published
2009

34. Epic-Italy Cohorts and Multipurpose National Surveys. A Comparison of Some Socio-Demographic and Life-Style Characteristics

Author

Calza, Stefano, primary, Specchia, Claudia, additional, Frasca, Graziella, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Fiorini, Laura, additional, Galasso, Rocco, additional, Ciardullo, Anna Vittoria, additional, Palli, Domenico, additional, Salvini, Simonetta, additional, Krogh, Vittorio, additional, Sieri, Sabina, additional, and Decarli, Adriano, additional

Published
2003
Full Text
View/download PDF

35. Diet in the Italian Epic Cohorts: Presentation of Data and Methodological Issues

Author

Pala, Valeria, primary, Sieri, Sabina, additional, Palli, Domenico, additional, Salvini, Simonetta, additional, Berrino, Franco, additional, Bellegotti, Manuela, additional, Frasca, Graziella, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Fiorini, Laura, additional, Celentano, Egidio, additional, Galasso, Rocco, additional, and Krogh, Vittorio, additional

Published
2003
Full Text
View/download PDF

36. Physical Activity in the EPIC-Italy Centers

Author

Salvini, Simonetta, primary, Saieva, Calogero, additional, Ciardullo, Anna Vittoria, additional, Panico, Salvatore, additional, Masala, Giovanna, additional, Assedi, Melania, additional, Berrino, Franco, additional, Pala, Valeria, additional, Frasca, Graziella, additional, Tumino, Rosario, additional, Veglia, Fabrizio, additional, Sacerdote, Carlotta, additional, and Palli, Domenico, additional

Published
2003
Full Text
View/download PDF

37. Urinary 1-Hydroxypyrene and t, t-Muconic ACID as Biomarkers of Exposure to Environmental Pollutants in Two Areas in Italy (Epic-Florence and Ragusa)

Author

Saieva, Calogero, primary, Tumino, Rosario, additional, Masala, Giovanna, additional, Frasca, Graziella, additional, Salvini, Simonetta, additional, Giurdanella, Maria Concetta, additional, Cerati, Marco, additional, Perico, Andrea, additional, Zanna, Ines, additional, Cordopatri, Giovanna, additional, Bevazzano, Paolo, additional, and Palli, Domenico, additional

Published
2003
Full Text
View/download PDF

38. Association between Social Class and Food Consumption in the Italian Epic Population

Author

Vannoni, Francesca, primary, Spadea, Teresa, additional, Frasca, Graziella, additional, Tumino, Rosario, additional, Demaria, Moreno, additional, Sacerdote, Carlotta, additional, Panico, Salvatore, additional, Celentano, Egidio, additional, Palli, Domenico, additional, Saieva, Calogero, additional, Pala, Valeria, additional, Sieri, Sabina, additional, and Costa, Giuseppe, additional

Published
2003
Full Text
View/download PDF

39. Cancer Incidence in Epic-Italy at First Follow-Up

Author

Tumino, Rosario, primary, Frasca, Graziella, additional, Palli, Domenico, additional, Masala, Giovanna, additional, Tagliabue, Giovanna, additional, Evangelista, Alberto, additional, Giurdanella, Maria Concetta, additional, Vineis, Paolo, additional, Veglia, Fabrizio, additional, Celentano, Egidio, additional, Galasso, Rocco, additional, and Cascone, Giuseppe, additional

Published
2003
Full Text
View/download PDF

40. Italy, Ragusa and Caltanissetta.

Author

Tumino, Rosario, Cascone, Giuseppe, Frasca, Graziella, Giurdanella, Maria Concetta, Martorana, Caterina, Nicita, Carmela, Rollo, Patrizia Concetta, and Spata, Eugenia

Subjects
NERVOUS system, SKIN cancer, GENITALIA, URINARY organs, CERVIX uteri, NON-Hodgkin's lymphoma
Published
2021

41. A Molecular Epidemiology Project on Diet and Cancer: The Epic-Italy Prospective Study. Design and Baseline Characteristics of Participants

Author

Palli, Domenico, Berrino, Franco, Vineis, Paolo, Tumino, Rosario, Panico, Salvatore, Masala, Giovanna, Saieva, Calogero, Salvini, Simonetta, Cerati, Marco, Pala, Valeria, Sieri, Sabina, Frasca, Graziella, Giurdanella, Maria Concetta, Sacerdote, Carlotta, Fiorini, Laura, Celentano, Egidio, Galasso, Rocco, Decarli, Adriano, Krogh, Vittorio, Palli, D, Masala, G, Saieva, C, Salvini, S, Assedi, M, Ceroti, M, Cordopatri, G, Ermini, I, Martinez, M, Tanzini, D, Zacchi, S, Zanna, I, Zappitello, C, Berrino, F, Krogh, V, Sieri, S, Pala, V, Fusconi, E, Tagliabue, G, Bellegotti, M, Evangelista, A, Del Sette, D, Foggetti, C, Vineis, P, Davico, L, Sacerdote, C, Fiorini, L, Veglia, F, Bertinetti, S, Tumino, R, Gafà, L, Frasca, G, Giurdanella, MC, Lauria, C, Martorana, C, Ruggeri, MG, Ruschena, AM, Panico, S, Celentano, E, Galasso, R, Ciardullo, AV, Del Pezzo, M, de Magistris, M Santucci, and Mattiello, A

Abstract

EPIC-Italy is the Italian section of a larger project known as EPIC (European Prospective Investigation into Cancer and Nutrition), a prospective study on diet and cancer carried out in 10 European countries. In the period 1993-1998, EPIC-Italy completed the recruitment of 47,749 volunteers (15,171 men, 32,578 women, aged 35-65 years) in 4 different areas covered by cancer registries: Varese (12,083 volunteers) and Turin (10,604) in the Northern part of the country; Florence (13,597) and Ragusa (6,403) in Central and Southern Italy, respectively. An associate center in Naples enrolled 5,062 women. Detailed information for each individual volunteer about diet and life-style habits, anthropometric measurements and a blood sample was collected, after signing an informed consent form. A food frequency questionnaire specifically developed for the Italian dietary pattern was tested in a pilot phase. A computerized data base with the dietary and lifestyle information of each participant was completed. Blood samples were processed in the same day of collection, aliquoted (RBC, WBC, serum and plasma) and stored in liquid nitrogen containers. Follow-up procedures were validated and implemented for the identification of newly diagnosed cancer cases. Cancer incidence was related to dietary habits and biochemical markers of food consumption and individual susceptibility in order to test the role of diet-related exposure in the etiology of cancer and its interaction with other environmental or genetic determinants. The comparability of information in a prospective study design is much higher than in other studies. The availability of such a large biological bank linked to individual data on dietary and life-style exposures also provides the unique opportunity of evaluating the role of selected genotypes involved in the metabolism of chemical compounds and DNA repair, potentially related to the risk of cancer, in residents of geographic areas of Italy characterized by specific cancer risk and different dietary patterns. Baseline characteristics of participants are briefly described.

Published
2003
Full Text
View/download PDF

42. DIETARY HABITS AND CANCER: THE EXPERIENCE OF EPIC-ITALY

Author

Sieri, Sabina, Agnoli, Claudia, Pala, Valeria, Amalia Mattiello, Panico, Salvatore, Masala, Giovanna, Assedi, Melania, Tumino, Rosario, Frasca, Graziella, Sacerdote, Carlotta, Vineis, Paolo, Krogh, Vittorio, Sieri, Sabina, Agnoli, Claudia, Pala, Valeria, Mattiello, Amalia, Panico, Salvatore, Masala, Giovanna, Assedi, Melania, Tumino, Rosario, Frasca, Graziella, Sacerdote, Carlotta, Vineis, Paolo, and Krogh, Vittorio

Abstract

to investigate hypothesised relationships between diet and cancer by assessing diet as a whole, in the Italian cohort EPIC.

43. [Dietary habits and cardiovascular disease: the experience of EPIC Italian collaboration]

Author

Amalia Mattiello, Chiodini, Paolo, Magistris, Maria Santucci, Krogh, Vittorio, Grioni, Sara, Fasanelli, Francesca, Vineis, Paolo, Saieva, Calogero, Bendinelli, Benedetta, Frasca, Graziella, Giurdanella, Maria Concetta, Panico, Salvatore, Mattiello, Amalia, Chiodini, Paolo, De Magistris, Maria Santucci, Krogh, Vittorio, Grioni, Sara, Fasanelli, Francesco, Vineis, Paolo, Saieva, Calogero, Bendinelli, Benedetto, Fresco, Graziella, Giurdanella, Maria Concetta, Panico, Salvatore, Santucci de Magistris, Maria, Fasanelli, Francesca, Bendinelli, Benedetta, and Frasca, Graziella

Subjects
Coronary heart disease, Cerebrovascular disease, Epic, Diet
Abstract

OBJECTIVES: To report and evaluate the evidence produced by the EPIC Italian collaboration (EPICOR Project) on the dietary determinants of cardiovascular diseases in Italy. DESIGN: prospective study carried out in a large Italian population, composed by cohorts recruited in Northern, Central and Southern Italy. SETTING AND PARTICIPANTS: data on dietary habits collected at the baseline observation through standardised questionnaires on 47,749 free-living adults at the time of the recruitment of the study (1993-1998). MAIN OUTCOME MEASURES: major coronary and cerebrovascular events (acute coronary syndrome, PTCA, CABG, ischemic and haemor- rhagic stroke, TEA of supraortic vessels) identified at follow-up. The longitudinal analyses here reported have measured risks through the use of multivariate Cox regression models, adjusted for potential confounders. RESULTS: The longitudinal analyses of EPICOR indicate that Mediter- ranean-oriented dietary habits, measured through specific indicators and the consumption of various typical food, are able to reduce coronary and cerebrovascular risks, and that this protection is possible even nowadays, although many changes in diet have occurred in the last decades in Italy. Habitual consumption of plant origin products, including all foods with low glycemic index, is an advantage for cardiovascular risk. CONCLUSIONS: The EPICOR Project is the largest, long-lasting Italian study on the relationship between diet and cardiovascular diseases. It is also the study with the greater number of observed variables. Its results point out the importance to support preventive programmes and industrial policies able to favour a dietary style inspired to the Italian Mediterranean tradition.

44. [AIRTUM numbers: 200,000 young Italians live with cancer]

Author

Dal Maso, Luigino, Angelis, Roberta, Guzzinati, Stefano, Airtum, Working Group, Paoli, Angela, Buzzoni, Carlotta, Crocetti, Emanuele, Bucchi, Lauro, Casella, Claudia, Cuccaro, Francesco, Fusco, Mario, Luminari, Stefano, Madeddu, Anselmo, Mangone, Lucia, Patriarca, Silvia, Piffer, Silvano, Stracci, Fabrizio, Tagliabue, Giovanna, Tumino, Rosario, Zappa, Marco, Capocaccia, Riccardo, Ferretti, Stefano, Mazzoleni, Guido, Bellu, Francesco, Tschugguel, Birgit, Valiere, Elena, Facchinelli, Gerlinde, Falk, Markus, Dal Cappello, Tomas, Giacomin, Adriano, Vercellino, Pier Carlo, Andreone, Simona, Busato, Anna, Marzola, Laura, Migliari, Elena, Carletti, Nada, Nenci, Italo, Caldarella, Adele, Corbinelli, Antonella, Giusti, Francesco, Intrieri, Teresa, Manneschi, Gianfranco, Nemcova, Libuse, Romeo, Gianpaolo, Sacchettini, Claudio, Paci, Eugenio, Serraino, Diego, Angelin, Tiziana, Bidoli, Ettore, Dottori, Margherita, Santis, Emilia, Forgiarini, Ornella, Zucchetto, Antonella, Zanier, Loris, Vercelli, Marina, Orengo, Maria Antonietta, Marani, Enza, Puppo, Antonella, Celesia, Maria Vittoria, Cogno, Roberta, Manenti, Simone, Garrone, Elsa, Quaglia, Alberto, Pannozzo, Fabio, Busco, Susanna, Rashid, Ivan, Ramazzotti, Valerio, Cercato, M. Cecilia, Battisti, Walter, Sperduti, Isabella, Macci, Leonarda, Bugliarello, Ester, Bernazza, Edvige, Tamburo, Lucilla, Rossi, Miriana, Curatella, Simonetta, Francesco, Carla, Tamburrino, Silvana, Bisanti, Luigi, Autelitano, Mariangela, Randi, Giorgia, Ghilardi, Simona, Leone, Rosanna, Filipazzi, Luisa, Bonini, Annamaria, Giubelli, Cinzia, Federico, Massimo, Artioli, Maria Elisa, Valla, Katia, Braghiroli, Barbara, Cirilli, Claudia, Pirani, Monica, Ferrari, Lorenza, Bellatalla, Caterina, Fusco, Maria, Panico, Margherita, Perrotta, Carmela, Vassante, Biagio, Traina, Adele, Carruba, Giuseppe, Cusimano, Rosanna, Amodio, Rosalba, Dolcemascolo, Cecilia, Staiti, Rosalba, Zarcone, Maurizio, Michiara, Maria, Bozzani, Francesco, Sgargi, Paolo, Cilia, Sonia, La Rosa, Maria Guglielmina, Cascone, Giuseppe, Frasca, Graziella, Giurdanella, Maria Concetta, Martorana, Caterina, Morana, Gabriele, Nicita, Carmela, Rollo, Patrizia, Ruggeri, Maria Grazia, Sigona, Aurora, Spata, Eugenia, Vacirca, Stefania, Di Felice, Enza, Pezzarossi, Annamaria, Caroli, Stefania, Pellegri, Carlotta, Vicentini, Massimo, Storchi, Cinzia, Cavuto, Silvio, Costa, Jaqueline, Falcini, Fabio, Colamartini, Americo, Balducci, Chiara, Ravegnani, Mila, Vitali, Benedetta, Cordaro, Carlo, Caprara, Licia, Giuliani, Orietta, Giorgetti, Stefania, Salvatore, Silvia, Palumbo, Monica, Vattiato, Rosa, Ravaioli, Alessandra, Foca, Flavia, Rinaldi, Elisa, Donato, Andrea, Iannelli, Arturo, Senatore, Gennaro, Zevola, Arrigo, Budroni, Mario, Cesaraccio, Rosaria, Pirino, Daniela, Carboni, Donatella, Fiori, Giovanna, Soddu, Marcella, Mameli, Gianpaolo, Mura, Francesco, Contrino, Maria Lia, Tisano, Francesco, Sciacca, Salvatore, Muni, Angela, Mizzi, Margherita, Russo, Maria, Tessandori, Roberto, Ardemagni, Giuseppina, Gianola, Luigi, Maspero, Sergio, Annulli, Monica Lucia, Moroni, Elena, Roberto, Guglielmana, Zanetti, Roberto, Rosso, Stefano, Prandi, Rossana, Sobrato, Irene, Gilardi, Franca, Busso, Paola, Franchini, Silva, Gentilini, Maria A., Battisti, Laura, Cappelletti, Maddalena, Moser, Marilena, La Rosa, Francesco, D Alo, Daniela, Scheibel, Massimo, Costarelli, Daniela, Spano, Francesco, Rossini, Stefania, Santucci, Cinzia, Petrinelli, Anna Maria, Solimene, Clotilde, Bianconi, Fortunato, Brunori, Valerio, Crosignani, Paolo, Contiero, Paolo, Preto, Lucia, Tittarelli, Andrea, Maghini, Anna, Codazzi, Tiziana, Frassoldi, Emanuela, Gada, Daniela, Costa, Enrica, Di Grazia, Laura, Zambon, Paola, Baracco, Maddalena, Bovo, Emanuela, Dal Cin, Antonella, Fiore, Anna Rita, Greco, Alessandra, Monetti, Daniele, Rosano, Alberto, Stocco, Carmen, Tognazzo, Sandro, Donato, Francesco, Limina, Rosa Maria, Adorni, Anna, Andreis, Paolo, Zani, Giuseppe, Piovani, Francesco, Salvi, Ornella, Puleio, Maria, Vitarelli, Susanna, Antonini, Silvia, Candela, Giuseppina, Pappalardo, Giuseppe, Scuderi, Tiziana, Lottero, Barbara, Ribaudo, Michele, Ricci, Paolo, Guarda, Linda, Gatti, Luciana, Bozzeda, Annalaura, Dall Acqua, Maria, Pironi, Vanda, Sardo, Antonella Sutera, Mazzei, Adriana, Sirianni, Nicola, Lavecchia, Anna Maria, Mancuso, Pierina, Usala, Mario, Pala, Filomena, Sini, Giovanna Maria, Pintori, Nicolina, Canu, Luisa, Demurtas, Giuliana, Doa, Nina, Pisani, Paola, Pastore, Guido, Magnani, Corrado, Terracini, Benedetto, Cena, Tiziana, Alessi, Daniela, Baussano, Iacopo, Merletti, Franco, Maule, Milena, Mosso, Maria Luisa, Nonnato, Marinella, Rasulo, Assunta, Richiardi, Lorenzo, Zuccolo, Luisa, Pivetta, Emanuele, Dalmasso, Paola, Macerata, Vanda, Leon, Maurizio Ponz, Domati, Federica, Rossi, Giuseppina, Goldoni, Carlo Alberto, Rossi, Federica, Gaetani, Carmela, Benatti, Piero, Roncucci, Luca, Di Gregorio, Carmela, Pezzi, Monica Pedroni Annalisa, Maffei, Stefania, Mariani, Francesco, Enrica Borsi, Cocchioni, Mario, Pascucci, Cristiana, Gennaro, Valerio, Lazzarotto, Anna, Benfatto, Lucia, Mazzucco, Giovanna, and Montanaro, Giovanna

45. Italian cancer figures, report 2013: Multiple tumours

Author

Airtum, Working Group, Adamo, Maria Stella, Alessi, Daniela, Aletta, Paoletta, Amodio, Rosalba, Andreone, Simona, Angelin, Tiziana, Anghinoni, Emanuela, Annulli, Monica Lucia, Antonini, Silvia, Artioli, Maria Elisa, Autelitano, Mariangela, Balducci, Chiara, Balottari, Paola, Baracco, Maddalena, Battisti, Walter, Bella, Francesca, Bellatalla, Caterina, Belluardo, Cristiano, Benatti, Piero, Benedetto, Giovanni, Benfatto, Lucia, Bernazza, Edvige, Bianconi, Fortunato, Biavati, Patrizia, Bidoli, Ettore, Birri, Silvia, Bizzoco, Sabrina, Bonelli, Luigina, Bonini, Annamaria, Borciani, Elisabetta, Bovo, Emanuela, Bozzani, Francesco, Bozzeda, Annalaura, Braghiroli, Barbara, Brucculeri, Maria Angela, Brunori, Valerio, Bucalo, Giovanni, Bucchi, Lauro, Bugliarello, Ester, Bulatko, Andreas, Busco, Susanna, Busso, Paola, Buzzoni, Carlotta, Calabretta, Laura, Caldarella, Adele, Candela, Giuseppina, Canu, Luisa, Cappelletti, Maddalena, Caprara, Licia, Carboni, Donatella, Carletti, Nada, Caroli, Stefania, Carone, Simona, Cascio, Maria Antonietta, Cascone, Giuseppe, Casella, Claudia, Castaing, Marine, Cecconami, Lorella, Celesia, Maria Vittoria, Cena, Tiziana, Cercato, Maria Cecilia, Cesaraccio, Rosaria, Chiesa, Roberta, Cirilli, Claudia, Civaschi, Alessandro, Cocchioni, Mario, Codazzi, Tiziana, Cogno, Roberta, Colamartini, Americo, Colanino Ziino, Antonino, Cometti, Ivan, Contiero, Paolo, Contrino, Maria Lia, Corbinelli, Antonella, Cordaro, Carlo, Corti, Mariangela, Costa, Alessandro, Costarelli, Daniela, Cremone, Luigi, Crocetti, Emanuele, Curatella, Simonetta, Cusimano, Rosanna, D Alo, Daniela, D Angelo, Stefania, Dal Cappello, Tomas, Dal Cin, Antonella, Dal Maso, Luigino, Dall Acqua, Maria, Dalsasso, Fernanda, Davini, Chiara, Dottori, Margherita, Maria, Valentina, Santis, Emilia, Valiere, Elena, Dei Tos, Angelo Paolo, Demurtas, Giuliana, Devigli, Elena, Di Felice, Enza, Di Grazia, Laura, Di Gregorio, Carmela, Di Prima, Alessia, Distefano, Rosalba, Doa, Nina, Domati, Federica, Fabiano, Sabrina, Facchinelli, Gerlinde, Falcini, Fabio, Falk, Markus, Fanetti, Anna Clara, Fattoruso, Silvia, Federico, Massimo, Ferrari, Lorenza, Ferretti, Stefano, Fidelbo, Melchiorre, Filipazzi, Luisa, Fiore, Anna Rita, Fiori, Giovanna, Foca, Flavia, Forgiarini, Ornella, Frasca, Graziella, Frassoldi, Emanuela, Frizza, Jacqueline, Fusco, Maria, Fusco, Mario, Gada, Daniela, Garrone, Elsa, Gasparotti, Cinzia, Gatti, Luciana, Gaudiano, Claudia, Gennaro, Valerio, Gentilini, Maria, Gerevini, Claudia, Ghilardi, Simona, Ghisleni, Silvia, Giacomin, Adriano, Giavazzi, Luisa, Gilardi, Franca, Giorgetti, Stefania, Giubelli, Cinzia, Giuliani, Orietta, Giurdanella, Maria Concetta, Gola, Gemma, Goldoni, Carlo Alberto, Golizia, Maria Grazia, Grandi, Luigi, Greco, Alessandra, Guarda, Linda, Guttadauro, Agnese, Guzzinati, Stefano, Iachetta, Francesco, Iannelli, Arturo, Ieni, Antonio, Intrieri, Teresa, Kaleci, Shaniko, La Rosa, Francesco, Lando, Cecilia, Lavecchia, Anna Maria, Lazzarato, Fulvio, Leone, Anna, Leone, Rosanna, Lonati, Fulvio, Lottero, Barbara, Lucchi, Silvia, Luminari, Stefano, Macci, Leonarda, Macerata, Vanda, Madeddu, Anselmo, Maffei, Stefania, Maghini, Anna, Magnani, Corrado, Magnani, Giulia, Magoni, Michele, Mameli, Gianpaolo, Mancini, Silvia, Mancuso, Pierina, Mangone, Lucia, Manneschi, Gianfranco, Mannino, Rita, Mannino, Salvatore, Marani, Enza, Mariani, Francesco, Martorana, Caterina, Marzola, Laura, Maspero, Sergio, Maule, Milena, Mazzei, Adriana, Mazzoleni, Guido, Mazzucco, Giovanna, Melcarne, Anna, Merletti, Franco, Michiara, Maria, Migliari, Elena, Minerba, Sante, Minicuzzi, Antonia, Mizzi, Margherita, Monetti, Daniele, Morana, Gabriele, Moroni, Elena, Mosso, Maria Luisa, Muni, Angela, Mura, Francesco, Natali, Maurilio, Nemcova, Libuse, Nicita, Carmela, Ocello, Cristina, Paci, Eugenio, Pala, Filomena, Palumbo, Monica, Panico, Margherita, Pannozzo, Fabio, Pascucci, Cristiana, Pastore, Guido, Patriarca, Silvia, Pedroni, Monica, Pellegri, Carlotta, Perrotta, Carmela, Pesce, Paola, Petrinelli, Anna Maria, Petrucci, Chiara, Pezzarossi, Annamaria, Piffer, Silvano, Pintori, Nicolina, Pirani, Monica, Pirino, Daniela, Pironi, Vanda, Ponz Leon, Maurizio, Prandi, Rossana, Prazzoli, Rita, Preto, Lucia, Puleio, Maria, Puppo, Antonella, Quaglia, Alberto, Quarta, Fabrizio, Quattrocchi, Maria, Raho, Anna Maria, Valerio Ramazzotti, Rashid, Ivan, Ravaioli, Alessandra, Ravazzolo, Barbara, Ravegnani, Mila, Reggiani-Bonetti, Luca, Ribaudo, Michele, Rinaldi, Elisa, Ricci, Paolo, Rizzello, Roberto, Rollo, Patrizia Concetta, Roncucci, Luca, Rosano, Alberto, Rossi, Federica, Rossi, Giuseppina, Rossi, Miriana, Rossini, Stefania, Rosso, Stefano, Rudisi, Giuseppa, Ruggeri, Maria Grazia, Russo, Antonio Giampiero, Russo, Maria, Sacchettini, Claudio, Sacco, Giorgio, Sacerdote, Carlotta, Salvatore, Silvia, Salvi, Ornella, Sampietro, Giuseppe, Sandrini, Monica, Santucci, Cinzia, Scheibel, Massimo, Schiacchitano, Salvatore, Sciacca, Salvatore, Sciacchitano, Carlo, Scuderi, Tiziana, Sechi, Ornelia, Seghini, Pietro, Senatore, Gennaro, Serafini, Giuseppina, Serraino, Diego, Sgargi, Paolo, Sigona, Aurora, Sini, Giovanna Maria, Sobrato, Irene, Soddu, Marcella, Solimene, Clotilde, Spano, Francesco, Spata, Eugenia, Sperduti, Isabella, Staiti, Rosalba, Stocco, Carmen, Stracci, Fabrizio, Sunseri, Raffaella, Sardo, Antonella Sutera, Tagliabue, Giovanna, Tamburo, Lucilla, Tamburrino, Silvana, Tanzarella, Margherita, Terracini, Benedetto, Tessandori, Roberto, Tisano, Francesco, Tittarelli, Andrea, Tognazzo, Sandro, Torrisi, Antonietta, Torrisi, Antonina, Traina, Adele, Trapani, Carlo, Tschugguel, Birgit, Tumino, Rosario, Usala, Mario, Vacirca, Stefania, Valerio, Orsola, Valla, Katia, Varvara, Massimo, Vasquez, Enrico, Vassante, Biagio, Vattiato, Rosa, Vercelli, Marina, Vercellino, Pier Carlo, Vicentini, Massimo, Villa, Marco, Vitale, Francesco, Vitale, Maria Francesca, Vitali, Benedetta, Vitarelli, Susanna, Zanchi, Andreina, Zanetti, Roberto, Zani, Giuseppe, Zanier, Loris, Zappa, Marco, Zarcone, Maurizio, Zevola, Arrigo, Zucchetto, Antonella, Zucchi, Alberto, Buzzoni, C, Crocetti, E, Bella, F, Bonelli, L, Caldarella, A, Castaing, M, Cercato, MC, Dal Maso, L, Dei Tos, AP, Ferretti, S, Giacomin, A, Pannozzo, F, Mazzoleni, G, Patriarca, S, Petrucci, S, Pisani, P, Ponz de Leon, P, Quaglia, A, Ramazzotti, V, Tumino, R, Vercelli, M, and Vitale, F

Subjects
Adult, Male, Data Interpretation, cancer incidence, Adolescent, Epidemiology, Settore MED/42 - Igiene Generale E Applicata, Neoplasms, Multiple Primary, Cohort Studies, Young Adult, Multiple Primary, Risk Factors, Neoplasms, 80 and over, Humans, Child, Preschool, Aged, Retrospective Studies, Aged, 80 and over, Incidence, Environmental and Occupational Health, multiple tumour, Infant, Neoplasms, Second Primary, italian cancer, multiple tumours, Statistical, Middle Aged, Multiple primary cancer incidence, Child, Preschool, Data Interpretation, Statistical, Female, Italy, Second Primary, Public Health, Environmental and Occupational Health, Public Health
Abstract

This collaborative study, based on data collected by the network of Italian association of cancer registries (AIRTUM), provides updated estimates on the incidence risk of multiple primary cancer (MP). The objective is to highlight and quantify the bidirectional associations between different oncological diseases. The quantification of the excess or decreased risk of further cancers in cancer patients, in comparison with the general population, may contribute to understand the aetiology of cancer and to address clinical follow-up.Data herein presented were provided by AIRTUM population-based cancer registries, which cover nowadays 48% of the Italian population. This monograph utilizes the AIRTUM database (December 2012), considering all malignant cancer cases diagnosed between 1976 and 2010. All cases are coded according to ICD-O-3. Non-melanoma skin cancer cases, cases based on death certificate only, cases based on autopsy only, and cases with follow-up time equal to zero were excluded. To define multiple primaries, IARC-IACR rules were adopted (http://www.iacr.com.fr/MPrules_july2004.pdf). Data were subjected to standard quality control procedures (described in the AIRTUM data management protocol) and specific quality control checks defined for the present study. A cohort of cancer patients was followed over time from first cancer diagnosis until the date of second cancer diagnosis, death, or the end of follow-up, to evaluate whether the number of observed second cancer cases was greater than expected. Person years at risk (PY) were computed by first cancer site, geographic area (North, Centre, South and Islands), attained age, and attained calendar-year group. All second cancers diagnosed in the cohort's patients were included in the observed numbers of cases. The expected number of cancer cases was computed multiplying the accumulated PY by the expected rates, calculated from the AIRTUM database stratified by cancer site, geographic area, age, and calendar-year group. The Standardized Incidence Ratio (SIR) was calculated as the ratio of observed to expected cancer cases. The Excess Absolute Risk (EAR) beyond the expected amount were calculated subtracting the expected number of subsequent cancers from the observed number of cancer cases; the difference was then divided by the PY and the number of cancer cases in excess (or deficit) was expressed per 1,000 PY. Confidence intervals were stated at 95%. The two months (60 days) after first cancer diagnosis were defined as "synchronicity period", and in the main analysis observed and expected cases during this period were excluded. It was estimated the excess risk in the period after first diagnosis (≥ 0 months), excluding the synchronicity period (≥ 2 months), and during the following periods: 2-11, 12-59, 60-119 and 120 months after diagnosis. First-cancer-site-and-gender-specific sheets are presented, reporting both SIRs and EARs.For 5,979,338 person-years a cohort of 1,635,060 cancer patients (880,361 males and 754,699 females) diagnosed between 1976 and 2010 was followed. The mean follow-up length was 14 years. Overall, 85,399 metachronous (latency ≥2 months) cancers were observed, while 77,813 were expected during the study period: SIR: 1.10 (95%CI 1.09-1.10), EAR: 1.32 x 1,000 person-years (95%CI 1.19 - 1.46). The SIR was 1.08 (95%CI 1.08-1.09) for men (54,518 observed and 50,260 expected) and 1.12 (95%CI 1.11-1.13) for women (30,881/27,553), and the EAR 1.61 (95%CI 1.37-1.84) and 1.08 x 1,000 person-years (95%CI 0.93-1.24), respectively.Moreover, during the first two months after first cancer diagnosis (synchronous period) 14,807 cancers were observed while 3,536 were expected (SIR: 4.16; 95%CI 4.09-4.22); the SIR was 4.08 (95%CI 4.00-4.16) for men and 4.32 (95%CI 4.20-4.45) for women.The mean age of patients at first cancer diagnosis was 67.0 years among males and 65.8 among females.The risk of MP was related to age being higher for younger patients and lower for older ones. In relation to the time of first cancer diagnosis, the SIR was very high at the beginning and then decreased, although remaining constantly over 1, and then rose over time. No strong differences were evident across the different incidence periods, which all showed an increased MP risk.Women had higher SIRs than expected for 18 cancer sites, men for 12. The statistically significantly SIRs lower than 1 were 2 and 8, respectively. Increased overall MP risk was observed for patients of both sexes with a first primary in the oral cavity (SIR men: 1.93; SIR women: 1.48), pharynx (SIR men: 2.13; SIR women: 1.99), larynx (SIR men: 1.57; SIR women: 1.79), oesophagus (SIR men: 1.45; SIR women: 1.41), lung (SIR men: 1.09; SIR women: 1.13), kidney (SIR men: 1.14; SIR women: 1.15), urinary bladder (SIR men: 1.29; SIR women: 1.22), thyroid (SIR: 1.22 in both sexes), Hodgkin lymphoma (SIR men: 1.59; SIR women: 1.94), and non-Hodgkin lymphoma (SIR men: 1.13; SIR women: 1.12), and for the heterogeneous group "other sites" (SIR men: 1.09; SIR women: 1.07). Moreover, men had a higher MP risk if the first cancer was in the testis (SIR: 1.24), while the same was true for women with gallbladder (SIR: 1.21), skin melanoma (SIR: 1.17), bone (SIR: 1.41), breast (SIR: 1.12), cervix uteri (SIR: 1.23) and corpus uteri (SIR: 1.23), and ovarian cancer (SIR: 1.18). On the contrary, a first liver or pancreas cancer were associated with a decreased MP risk in both sexes (liver SIR: 0.86 and 0.81 for men and women, respectively; pancreas SIR: 0.70 and 0.78 for men and women, respectively), as were those of colon (SIR: 0.93), rectum (SIR: 0.83), gallbladder (SIR: 0.80), prostate (SIR: 0.93), mesothelioma (SIR: 0.65), and central nervous system (SIR: 0.82) among men. Among the cancers for which the EAR is statistically significant, those with higher Excess Absolute Risk of MP were those of the oral cavity (EAR: 16.0 x 1,000 person-years in men and 5.4 in women), pharynx (17.6 and 9.1), larynx (11.4 and 8.8), and oesophagus (8.5 and 4.8).This descriptive study provides quantitative information on the risk of developing a second cancer in an Italian population-based cohort of approximately 1.65 million cancer patients, compared to the risk of the general population. During the follow-up time (on average 14 years) cancer patients had an MP risk that was 10% higher in comparison to the general population and an Excess Absolute Risk of 1.32 x 1,000 person-years. Study of MPs and their risk measures are dependent on methods used in the calculation. The definition of MP is not univocal and using different rules can greatly change the number of cancers in a patient with MPs. However, the AIRTUM cancer registries adopt the same recommendations for MP definition. This monograph was therefore made possible by the shared rules and standards used by AIRTUM registries. The cancer site-specific sheets, which represent the core of the monograph, can be useful to highlight and quantify the bidirectional associations among different diseases and therefore provide indications for clinical follow-up. Lifestyle changes in more healthful directions can have a positive effect in the cancer patient population and should always be recommended.

46. [Italian cancer figures, report 2010: Cancer prevalence in Italy. Patients living with cancer, long-term survivors and cured patients]

Author

Airtum, Working Group, Guzzinati, Stefano, Dal Maso, Luigino, Angelis, Roberta, Paoli, Angela, Buzzoni, Carlotta, Crocetti, Emanuele, Bucchi, Lauro, Casella, Claudia, Cuccaro, Francesco, Fusco, Mario, Luminari, Stefano, Madeddu, Anselmo, Mangone, Lucia, Patriarca, Silvia, Piffer, Silvano, Stracci, Fabrizio, Tagliabue, Giovanna, Tumino, Rosario, Zappa, Marco, Capocaccia, Riccardo, Ferretti, Stefano, Mazzoleni, Guido, Bellu, Francesco, Tschugguel, Birgit, Valiere, Elena, Facchinelli, Gerlinde, Falk, Markus, Dal Cappello, Tomas, Giacomin, Adriano, Vercellino, Pier Carlo, Andreone, Simona, Busato, Anna, Marzola, Laura, Migliari, Elena, Carletti, Nada, Nenci, Italo, Caldarella, Adele, Corbinelli, Antonella, Giusti, Francesco, Intrieri, Teresa, Manneschi, Gianfranco, Nemcova, Libuse, Romeo, Gianpaolo, Sacchettini, Claudio, Paci, Eugenio, Serraino, Diego, Angelin, Tiziana, Bidoli, Ettore, Dottori, Margherita, Santis, Emilia, Forgiarini, Ornella, Zucchetto, Antonella, Zanier, Loris, Vercelli, Marina, Orengo, Maria Antonietta, Marani, Enza, Puppo, Antonella, Celesia, Maria Vittoria, Cogno, Roberta, Manenti, Simone, Garrone, Elsa, Quaglia, Alberto, Pannozzo, Fabio, Busco, Susanna, Rashid, Ivan, Ramazzotti, Valerio, Cercato, M. Cecilia, Battisti, Walter, Sperduti, Isabella, Macci, Leonarda, Bugliarello, Ester, Bernazza, Edvige, Tamburo, Lucilla, Rossi, Miriana, Curatella, Simonetta, Francesco, Carla, Tamburrino, Silvana, Bisanti, Luigi, Autelitano, Mariangela, Randi, Giorgia, Ghilardi, Simona, Leone, Rosanna, Filipazzi, Luisa, Bonini, Annamaria, Giubelli, Cinzia, Federico, Massimo, Artioli, Maria Elisa, Valla, Katia, Braghiroli, Barbara, Cirilli, Claudia, Pirani, Monica, Ferrari, Lorenza, Bellatalla, Caterina, Fusco, Maria, Panico, Margherita, Perrotta, Carmela, Vassante, Biagio, Traina, Adele, Carruba, Giuseppe, Cusimano, Rosanna, Amodio, Rosalba, Dolcemascolo, Cecilia, Staiti, Rosalba, Zarcone, Maurizio, Michiara, Maria, Bozzani, Francesco, Sgargi, Paolo, Cilia, Sonia, La Rosa, Maria Guglielmina, Cascone, Giuseppe, Frasca, Graziella, Giurdanella, Maria Concetta, Martorana, Caterina, Morana, Gabriele, Nicita, Carmela, Rollo, Patrizia, Ruggeri, Maria Grazia, Sigona, Aurora, Spata, Eugenia, Vacirca, Stefania, Di Felice, Enza, Pezzarossi, Annamaria, Caroli, Stefania, Pellegri, Carlotta, Vicentini, Massimo, Storchi, Cinzia, Cavuto, Silvio, Costa, Jaqueline, Falcini, Fabio, Colamartini, Americo, Balducci, Chiara, Ravegnani, Mila, Vitali, Benedetta, Cordaro, Carlo, Caprara, Licia, Giuliani, Orietta, Giorgetti, Stefania, Salvatore, Silvia, Palumbo, Monica, Vattiato, Rosa, Ravaioli, Alessandra, Foca, Flavia, Rinaldi, Elisa, Donato, Andrea, Iannelli, Arturo, Senatore, Gennaro, Zevola, Arrigo, Budroni, Mario, Cesaraccio, Rosaria, Pirino, Daniela, Carboni, Donatella, Fiori, Giovanna, Soddu, Marcella, Mameli, Gianpaolo, Mura, Francesco, Contrino, Maria Lia, Tisano, Francesco, Sciacca, Salvatore, Muni, Angela, Mizzi, Margherita, Russo, Maria, Tessandori, Roberto, Ardemagni, Giuseppina, Gianola, Luigi, Maspero, Sergio, Annulli, Monica Lucia, Moroni, Elena, Roberto, Guglielmana, Zanetti, Roberto, Rosso, Stefano, Prandi, Rossana, Sobrato, Irene, Gilardi, Franca, Busso, Paola, Franchini, Silva, Gentilini, Maria A., Battisti, Laura, Cappelletti, Maddalena, Moser, Marilena, La Rosa, Francesco, D Alo, Daniela, Scheibel, Massimo, Costarelli, Daniela, Spano, Francesco, Rossini, Stefania, Santucci, Cinzia, Petrinelli, Anna Maria, Solimene, Clotilde, Bianconi, Fortunato, Brunori, Valerio, Crosignani, Paolo, Contiero, Paolo, Preto, Lucia, Tittarelli, Andrea, Maghini, Anna, Codazzi, Tiziana, Frassoldi, Emanuela, Gada, Daniela, Costa, Enrica, Di Grazia, Laura, Zambon, Paola, Baracco, Maddalena, Bovo, Emanuela, Dal Cin, Antonella, Fiore, Anna Rita, Greco, Alessandra, Monetti, Daniele, Rosano, Alberto, Stocco, Carmen, Tognazzo, Sandro, Donato, Francesco, Limina, Rosa Maria, Adorni, Anna, Andreis, Paolo, Zani, Giuseppe, Piovani, Francesco, Salvi, Ornella, Puleio, Maria, Vitarelli, Susanna, Antonini, Silvia, Candela, Giuseppina, Pappalardo, Giuseppe, Scuderi, Tiziana, Lottero, Barbara, Ribaudo, Michele, Ricci, Paolo, Guarda, Linda, Gatti, Luciana, Bozzeda, Annalaura, Dall Acqua, Maria, Pironi, Vanda, Sutera Sardo, Antonella, Mazzei, Adriana, Sirianni, Nicola, Lavecchia, Anna Maria, Mancuso, Pierina, Usala, Mario, Pala, Filomena, Sini, Giovanna Maria, Pintori, Nicolina, Canu, Luisa, Demurtas, Giuliana, Doa, Nina, Pisani, Paola, Pastore, Guido, Magnani, Corrado, Terracini, Benedetto, Cena, Tiziana, Alessi, Daniela, Baussano, Iacopo, Merletti, Franco, Maule, Milena, Mosso, Maria Luisa, Nonnato, Marinella, Rasulo, Assunta, Richiardi, Lorenzo, Zuccolo, Luisa, Pivetta, Emanuele, Dalmasso, Paola, Macerata, Vanda, Ponz Leon, Maurizio, Domati, Federica, Rossi, Giuseppina, Goldoni, Carlo Alberto, Rossi, Federica, Gaetani, Carmela, Benatti, Piero, Roncucci, Luca, Di Gregorio, Carmela, Pedroni, Monica, Pezzi, Annalisa, Maffei, Stefania, Mariani, Francesco, Enrica Borsi, Cocchioni, Mario, Pascucci, Cristiana, Gennaro, Valerio, Lazzarotto, Anna, Benfatto, Lucia, Mazzucco, Giovanna, Montanaro, Fabio, AIRTUM Working Group […, Enrica, Borsi, and …]

Subjects
Adult, Male, Time Factors, Adolescent, Databases, Factual, Remission Induction, Infant, Middle Aged, CANCER, Cancer prevalence, Italy, Epidemiologic Studies, Young Adult, Child, Preschool, Neoplasms, Prevalence, Humans, Long-term survivors, Female, Registries, Survivors, Child, Aged
Abstract

OBJECTIVES: the aim of the present monograph is to update the estimation of the number of people living with cancer in Italy, to describe geographic variability, and estimate the number of long-term survivors, i.e., people living five years or more after a cancer diagnosis. MATERIALS AND METHODS: the study included the data of the AIRTUMdatabase. Twenty-four Cancer Registries (CRs) (covering 27% of the Italian population) collected information on the incidence and vital status of 1,275,353 cases diagnosed between 1978 and 2005. For each CR, the observed prevalence was calculated up to the maximum observable duration. To estimate the complete prevalence (all living patients, independently from time since diagnosis) and the prevalence for lengths of time exceeding the CR maximum duration of registration, the observed prevalence was corrected through a completeness index. Completeness indices, gender, age and site specific, were estimated by means of statistical regression models using cancer incidence and survival data available from CRs with more than 15 years of observation. As of 1 January 2006, the prevalence was estimated (as absolute numbers and as a proportion per 100,000 inhabitants) for 46 cancer sites, by gender, age class, years since diagnosis and geographic areas. RESULTS: as of 2006, 2,244,000 persons (4%of the Italian population) were alive with a cancer diagnosis. A relevant geographic variability emerged, with proportions between 4%-5% among CRs in the Centre and North of Italy, and proportions between 2%-3% in the South. Forty-four percent of prevalent subjects (988,000) were males and 56% (1,256,000) females. Fifty-seven percent (1,285,680 people, 2.2% of total population) of these patients was represented by long-term survivors. In patients aged 75 years or more, the proportions of prevalent cases were 19%in males and 13%in females, and 10%between 60 and 75 years of age in both genders.More than half a million Italian women were alive with a breast cancer diagnosis (42%of women with a neoplasm), followed by women with cancers of the colonrectum (12%), corpus uteri (7%), thyroid (5%), and cervix uteri (4%). In men, 22%of prevalent cases (216,716) included patients with prostate cancer, 18% with bladder cancer, and 15%with colon-rectum cancer. Percentages of long-term survivors higher than 70% were reported for cancers of the cervix uteri (82% at five years, and 55% at 15 years from diagnosis), Hodgkin lymphoma, testis, brain and central nervous system, bone and connective tissue. Many patients with these types of cancers (often occurring in young people) can be considered "cured", i.e., with a life expectancy overlapping that of the general population.The estimated proportions of prevalent cases emerging from this study in Italy were quite similar to those reported in Northern Europe, but at least 15%lower than those in the United States. CONCLUSIONS: in 2006, the number of prevalent cases nearly doubled compared to 1992. The increase over time in the proportion of elderly patients, related to population ageing, requires adequate health policies. Knowing the number of people alive many years after cancer diagnosis (either cured or long-term survivors) provides the scientific bases for the definition of health policies focusing on them. Furthermore, it promotes the conduction of studies aimed at improving the present knowledge on the quality of life of these patients during and after the active phase of treatments, in addition to studies on the long-term effects of treatments.

47. Impact of preventable risk factors on stroke in the EPICOR study: does gender matter?

Author

Calogero Saieva, Angelo d’Errico, Fulvio Ricceri, Valeria Pala, Paolo Chiodini, Carlotta Sacerdote, Giovanna Masala, Francesca Fasanelli, Slavica Trajkova, Graziella Frasca, Rosario Tumino, Salvatore Panico, Claudia Agnoli, Amalia Mattiello, Trajkova, Slavica, Dâ errico, Angelo, Ricceri, Fulvio, Fasanelli, Francesca, Pala, Valeria, Agnoli, Claudia, Tumino, Rosario, Frasca, Graziella, Masala, Giovanna, Saieva, Calogero, Chiodini, Paolo, Mattiello, Amalia, Sacerdote, Carlotta, and Panico, Salvatore

Subjects
Adult, Male, medicine.medical_specialty, Pediatrics, Health (social science), Disease, Cohort Studies, Stroke risk, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Preventive fraction, Humans, 030212 general & internal medicine, Sex Distribution, Stroke, Aged, Proportional hazards model, business.industry, Hazard ratio, Cohort study, Gender medicine, Population-attributable fraction, Risk factors, Public Health, Environmental and Occupational Health, Environmental and Occupational Health, Middle Aged, medicine.disease, Italy, Cohort, Female, Risk factor, Public Health, business, Alcohol consumption, 030217 neurology & neurosurgery
Abstract

Objectives: The effect of modifiable stroke risk factors in terms of prevented cases remains unclear due to sex-specific disease rate and risk factors prevalence. Our aim was to estimate their impact on stroke by gender through population-attributable fraction (PAF), preventive fraction (PF) and their combination in EPIC-Italian cohort. Methods: 43,976 participants, age 34–75, and free of cardiovascular disease at baseline (1993–1998) were followed up for almost 11 years. Adjusted hazard ratios and PAF were estimated using Cox models. Results: We identified 386 cases. In males, the burden for stroke was 17% (95% CI 4–28%) for smoking and 14% (95% CI 5–22%) for alcohol consumption. In females, hypertension was carrying the biggest burden with 18% (95% CI 9–26%) followed by smoking 15% (95% CI 7–22%). Their combination was 46% (95% CI 32–58%) in males and 48% (95% CI 35–59%) in females. PF for current smokers was gender unequal [males 21% (95% CI 15–27%) females 9% (95% CI 1–17%)]. Conclusions: Half of strokes are attributable to potentially modifiable factors. The proportion of prevented cases is gender unbalanced, encouraging sex-specific intervention.

Published
2017

48. Up to one-third of breast cancer cases in post-menopausal Mediterranean women might be avoided by modifying lifestyle habits: the EPIC Italy study

Author

Ines Zanna, Carlotta Sacerdote, Fulvio Ricceri, Rosario Tumino, Giovanna Masala, Claudia Agnoli, Graziella Frasca, Salvatore Panico, Amalia Mattiello, Daniela Occhini, Sabina Sieri, Melania Assedi, Domenico Palli, Calogero Saieva, Benedetta Bendinelli, Masala, Giovanna, Bendinelli, Benedetta, Assedi, Melania, Occhini, Daniela, Zanna, Ine, Sieri, Sabina, Agnoli, Claudia, Sacerdote, Carlotta, Ricceri, Fulvio, Mattiello, Amalia, Panico, Salvatore, Tumino, Rosario, Frasca, Graziella, Saieva, Calogero, and Palli, Domenico

Subjects
Adult, Cancer Research, medicine.medical_specialty, Alcohol Drinking, Breast Neoplasms, Overweight, Post-menopausal breast cancer, 03 medical and health sciences, Habits, 0302 clinical medicine, Breast cancer, Risk Factors, medicine, Humans, Population attributable risk, 030212 general & internal medicine, Prospective study, Prospective cohort study, Alcohol, Body mass index, Physical activity, Exercise, Female, Follow-Up Studies, Italy, Middle Aged, Proportional Hazards Models, Sedentary Behavior, Life Style, Postmenopause, Sedentary lifestyle, Gynecology, business.industry, Anthropometry, medicine.disease, Obesity, Oncology, 030220 oncology & carcinogenesis, Attributable risk, medicine.symptom, business, Demography
Abstract

Breast cancer (BC) is the most frequent cancer among women in developed countries. Physical activity (PA), body mass index (BMI), and alcohol intake have been identified as relevant lifestyle modifiable risk factors for post-menopausal BC. We aimed to evaluate the role of these factors in modulating post-menopausal BC risk and to estimate the proportion of BC cases attributable to low PA, high BMI, and alcohol taking into account non-modifiable factors. In the Italian section of the EPIC study, 15,010 post-menopausal women were recruited and provided information about dietary and lifestyle habits including PA, smoking, reproductive history, and anthropometric measurements. During 14.8 years of median follow-up, 672 incident BC cases (607 invasive and 65 in situ) were identified. In multivariate models, inverse associations with BC risk emerged for increasing level of total (p trend 0.02), leisure time (p trend 0.04), and occupational (p trend 0.007) PA. High BMI (HR 1.21; 95% CI 1.02–1.43 and HR 1.33; 95% CI 1.06–1.65 for overweight and obesity, respectively) and alcohol consumption higher than 10 g/day (HR 1.30; 95% CI 1.09–1.54) were associated with BC risk. We estimated that 30% (95% CI 8–50%) of post-menopausal BC cases would be avoided through an increase of leisure time PA, a BMI below 25.0, and consuming no more than one drink/day. This large study carried out in Mediterranean women confirms the role of PA, BMI, and alcohol consumption in modulating post-menopausal BC risk and supports the potential benefits obtainable by modifying these lifestyle factors.

Published
2017

49. Gene-specific DNA methylation profiles and LINE-1 hypomethylation are associated with myocardial infarction risk

Author

Alessia Russo, Graziella Frasca, Salvatore Panico, Giovanni Fiorito, Amalia Mattiello, Vittorio Krogh, Yvonne T. van der Schouw, Silvia Polidoro, Giuseppe Matullo, N. Charlotte Onland-Moret, Paolo Vineis, Rosario Tumino, Carlotta Sacerdote, Simonetta Guarrera, Claudia Agnoli, Monique Verschuren, Licia Iacoviello, Cornelia Di Gaetano, Fulvio Ricceri, Alessandra Allione, Paolo Chiodini, Jolanda M. A. Boer, Guarrera, Simonetta, Fiorito, Giovanni, Onland Moret, N. Charlotte, Russo, Alessia, Agnoli, Claudia, Allione, Alessandra, Di Gaetano, Cornelia, Mattiello, Amalia, Ricceri, Fulvio, Chiodini, Paolo, Polidoro, Silvia, Frasca, Graziella, Verschuren, Monique W. M., Boer, Jolanda M. A., Iacoviello, Licia, van der Schouw, Yvonne T., Tumino, Rosario, Vineis, Paolo, Krogh, Vittorio, Panico, Salvatore, Sacerdote, Carlotta, Matullo, Giuseppe, Verschuren, Monique W. M, Boer, Jolanda M. A, and van der Schouw, Yvonne T

Subjects
Oncology, medicine.medical_specialty, Population, BLOOD-PRESSURE, HEART-DISEASE, Biology, Bioinformatics, Early biomarkers, DESIGN, Genetic, Internal medicine, BINDING, medicine, Genetics, COHORT, Association study, DNA methylation, Myocardial infarction, Risk prediction, Risk stratification, Molecular Biology, Developmental Biology, Genetics (clinical), education, Gene, POPULATION, Early biomarker, education.field_of_study, Science & Technology, Microarray analysis techniques, Research, CARDIOVASCULAR-DISEASE RISK, Methylation, medicine.disease, European Prospective Investigation into Cancer and Nutrition, GENOME, Cohort, GENDER, Life Sciences & Biomedicine, PROJECT
Abstract

Background DNA methylation profiles are responsive to environmental stimuli and metabolic shifts. This makes DNA methylation a potential biomarker of environmental-related and lifestyle-driven diseases of adulthood. Therefore, we investigated if white blood cells’ (WBCs) DNA methylation profiles are associated with myocardial infarction (MI) occurrence. Whole-genome DNA methylation was investigated by microarray analysis in 292 MI cases and 292 matched controls from the large prospective Italian European Prospective Investigation into Cancer and Nutrition (EPIC) cohort (EPICOR study). Significant signals (false discovery rate (FDR) adjusted P

Published
2015

50. Differentially methylated microRNAs in prediagnostic samples of subjects who developed breast cancer in the European Prospective Investigation into Nutrition and Cancer (EPIC-Italy) cohort

Author

Carlotta Sacerdote, Gianluca Campanella, Francesca Cordero, Domenico Palli, Giulio Ferrero, Vittorio Krogh, Paolo Vineis, Claudia Agnoli, Giovanni Fiorito, Alessio Naccarati, Amalia Mattiello, Silvia Polidoro, Giovanna Masala, Graziella Frasca, Salvatore Panico, Rosario Tumino, Cordero, Francesca, Ferrero, Giulio, Polidoro, Silvia, Fiorito, Giovanni, Campanella, Gianluca, Sacerdote, Carlotta, Mattiello, Amalia, Masala, Giovanna, Agnoli, Claudia, Frasca, Graziella, Panico, Salvatore, Palli, Domenico, Krogh, Vittorio, Tumino, Rosario, Vineis, Paolo, and Naccarati, Alessio

Subjects
Oncology, Adult, Male, medicine.medical_specialty, Cancer Research, Prognosi, Colorectal cancer, Carcinogenesis, Breast Neoplasms, Colorectal Neoplasm, medicine.disease_cause, Breast cancer, Internal medicine, microRNA, Medicine, Humans, Epigenetics, Prospective cohort study, business.industry, Case-control study, MicroRNA, General Medicine, DNA Methylation, Middle Aged, medicine.disease, Prognosis, Gene Expression Regulation, Neoplastic, MicroRNAs, Italy, Case-Control Studies, DNA methylation, Female, Case-Control Studie, business, Colorectal Neoplasms, Breast Neoplasm, Human
Abstract

The crosstalk between microRNAs (miRNAs) and other epigenetic factors may lead to novel hypotheses about carcinogenesis identifying new targets for research. Because a single miRNA can regulate multiple downstream target genes, its altered expression may potentially be a sensitive biomarker to detect early malignant transformation and improve diagnosis and prognosis. In the current study, we tested the hypothesis that altered methylation of miRNA encoding genes, associated with deregulated mature miRNA expression, may be related to dietary and lifestyle factors and may contribute to cancer development. In a case-control study nested in a prospective cohort (EPIC-Italy), we analysed DNA methylation levels of miRNA encoding genes (2191 CpG probes related to 517 genes) that are present in the Infinium Human Methylation450 BeadChip array in prediagnostic peripheral white blood cells of subjects who developed colorectal cancer (CRC, n = 159) or breast cancer (BC, n = 166) and matched subjects who remained clinically healthy. In the whole cohort, several differentially methylated miRNA genes were observed in association with age, sex, smoking habits and physical activity. Interestingly, in the case-control study, eight differentially methylated miRNAs were identified in subjects who went on to develop BC (miR-328, miR-675, miR-1307, miR-1286, miR-1275, miR-1910, miR-24-1 and miR-548a-1; all Bonferroni-adjusted P < 0.05). No significant associations were found with CRC. Assuming that altered methylation of miRNAs detectable in blood may be present before diagnosis, it may represent a biomarker for early detection or risk of cancer and may help to understand the cascade of events preceding tumour onset.

Published
2015

Catalog

Books, media, physical & digital resources
See catalog results