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309 results on '"Frapolli, Roberta"'

3. Validated LC-MS/MS Assay for the Quantitative Determination of Fenretinide in Plasma and Tumor and Its Application in a Pharmacokinetic Study in Mice of a Novel Oral Nanoformulation of Fenretinide

Author

Matteo, Cristina, primary, Orienti, Isabella, additional, Eramo, Adriana, additional, Zeuner, Ann, additional, Ferrari, Mariella, additional, Passoni, Alice, additional, Bagnati, Renzo, additional, Ponzo, Marianna, additional, Bello, Ezia, additional, Zucchetti, Massimo, additional, and Frapolli, Roberta, additional

Published
2024
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5. Distribution of pamiparib, a novel inhibitor of poly(ADP-ribose)-polymerase (PARP), in tumor tissue analyzed by multimodal imaging

Author

Morosi, L, Timo, S, Amodeo, R, Lupi, M, Meroni, M, Bello, E, Frapolli, R, Martano, G, D'Incalci, M, Morosi, Lavinia, Timo, Sara, Amodeo, Rosy, Lupi, Monica, Meroni, Marina, Bello, Ezia, Frapolli, Roberta, Martano, Giuseppe, D'Incalci, Maurizio, Morosi, L, Timo, S, Amodeo, R, Lupi, M, Meroni, M, Bello, E, Frapolli, R, Martano, G, D'Incalci, M, Morosi, Lavinia, Timo, Sara, Amodeo, Rosy, Lupi, Monica, Meroni, Marina, Bello, Ezia, Frapolli, Roberta, Martano, Giuseppe, and D'Incalci, Maurizio

Published
2024

7. Validated Lc-Ms/Ms Assay for the Quantitative Determination of Fenretinide in Plasma and Tumor and Its Application to Pharmacokinetic Study in Mice of a Novel Oral Nanoformulation of Fenretinide

Author

Matteo, Cristina, primary, Orienti, Isabella, additional, Eramo, Adriana, additional, Zeuner, Ann, additional, Ferrari, Mariella, additional, Passoni, Alice, additional, Bagnati, Renzo, additional, Ponzo, Marianna, additional, Bello, Ezia, additional, Zucchetti, Massimo, additional, and Frapolli, Roberta, additional

Published
2024
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8. Development of a HPLC-MS/MS Method to Assess the Pharmacokinetics and Tumour Distribution of the Dimethylarginine Dimethylaminohydrolase 1 Inhibitors ZST316 and L-257 in a Xenograft Model of Triple-Negative Breast Cancer in Mice

Author

Ceruti, Tommaso, primary, Frapolli, Roberta, additional, Ghilardi, Carmen, additional, Decio, Alessandra, additional, Dellavedova, Giulia, additional, Tommasi, Sara, additional, Zucchetti, Massimo, additional, and Mangoni, Arduino A., additional

Published
2023
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11. Development of a HPLC-MS/MS Method to Assess the Pharmacokinetics and Tumour Distribution of the Dimethylarginine Dimethylaminohydrolase 1 Inhibitors ZST316 and L-257 in a Xenograft Model of Triple Negative Breast Cancer

Author

Ceruti, Tommaso, primary, Frapolli, Roberta, additional, Ghilardi, Carmen, additional, Decio, Alessandra, additional, Dellavedova, Giulia, additional, Tommasi, Sara, additional, Zucchetti, Massimo, additional, and Mangoni, Arduino A, additional

Published
2023
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14. Chemotherapy-induced neutropenia elicits metastasis formation in mice by promoting proliferation of disseminated tumor cells

Author

Russo, Massimo, primary, Panini, Nicolò, additional, Fabbrizio, Paola, additional, Formenti, Laura, additional, Becchetti, Riccardo, additional, Matteo, Cristina, additional, Meroni, Marina, additional, Nastasi, Claudia, additional, Cappelleri, Andrea, additional, Frapolli, Roberta, additional, Nardo, Giovanni, additional, Scanziani, Eugenio, additional, Ponzetta, Andrea, additional, Bani, Maria Rosa, additional, Ghilardi, Carmen, additional, and Giavazzi, Raffaella, additional

Published
2023
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16. Supplementary Figure 2 from Bevacizumab-Induced Inhibition of Angiogenesis Promotes a More Homogeneous Intratumoral Distribution of Paclitaxel, Improving the Antitumor Response

Author

Cesca, Marta, primary, Morosi, Lavinia, primary, Berndt, Alexander, primary, Nerini, Ilaria Fuso, primary, Frapolli, Roberta, primary, Richter, Petra, primary, Decio, Alessandra, primary, Dirsch, Olaf, primary, Micotti, Edoardo, primary, Giordano, Silvia, primary, D'Incalci, Maurizio, primary, Davoli, Enrico, primary, Zucchetti, Massimo, primary, and Giavazzi, Raffaella, primary

Published
2023
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17. Supplementary Methods from Bevacizumab-Induced Inhibition of Angiogenesis Promotes a More Homogeneous Intratumoral Distribution of Paclitaxel, Improving the Antitumor Response

Author

Cesca, Marta, primary, Morosi, Lavinia, primary, Berndt, Alexander, primary, Nerini, Ilaria Fuso, primary, Frapolli, Roberta, primary, Richter, Petra, primary, Decio, Alessandra, primary, Dirsch, Olaf, primary, Micotti, Edoardo, primary, Giordano, Silvia, primary, D'Incalci, Maurizio, primary, Davoli, Enrico, primary, Zucchetti, Massimo, primary, and Giavazzi, Raffaella, primary

Published
2023
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18. Data from Bevacizumab-Induced Inhibition of Angiogenesis Promotes a More Homogeneous Intratumoral Distribution of Paclitaxel, Improving the Antitumor Response

Author

Cesca, Marta, primary, Morosi, Lavinia, primary, Berndt, Alexander, primary, Nerini, Ilaria Fuso, primary, Frapolli, Roberta, primary, Richter, Petra, primary, Decio, Alessandra, primary, Dirsch, Olaf, primary, Micotti, Edoardo, primary, Giordano, Silvia, primary, D'Incalci, Maurizio, primary, Davoli, Enrico, primary, Zucchetti, Massimo, primary, and Giavazzi, Raffaella, primary

Published
2023
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19. Supplementary Figure 1 from Bevacizumab-Induced Inhibition of Angiogenesis Promotes a More Homogeneous Intratumoral Distribution of Paclitaxel, Improving the Antitumor Response

Author

Cesca, Marta, primary, Morosi, Lavinia, primary, Berndt, Alexander, primary, Nerini, Ilaria Fuso, primary, Frapolli, Roberta, primary, Richter, Petra, primary, Decio, Alessandra, primary, Dirsch, Olaf, primary, Micotti, Edoardo, primary, Giordano, Silvia, primary, D'Incalci, Maurizio, primary, Davoli, Enrico, primary, Zucchetti, Massimo, primary, and Giavazzi, Raffaella, primary

Published
2023
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20. Supplementary Figure 3 from Bevacizumab-Induced Inhibition of Angiogenesis Promotes a More Homogeneous Intratumoral Distribution of Paclitaxel, Improving the Antitumor Response

Author

Cesca, Marta, primary, Morosi, Lavinia, primary, Berndt, Alexander, primary, Nerini, Ilaria Fuso, primary, Frapolli, Roberta, primary, Richter, Petra, primary, Decio, Alessandra, primary, Dirsch, Olaf, primary, Micotti, Edoardo, primary, Giordano, Silvia, primary, D'Incalci, Maurizio, primary, Davoli, Enrico, primary, Zucchetti, Massimo, primary, and Giavazzi, Raffaella, primary

Published
2023
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21. Supplementary Figure S5 from Trabectedin Efficacy in Ewing Sarcoma Is Greatly Increased by Combination with Anti-IGF Signaling Agents

Author

Amaral, Ana Teresa, primary, Garofalo, Cecilia, primary, Frapolli, Roberta, primary, Manara, Maria Cristina, primary, Mancarella, Caterina, primary, Uboldi, Sarah, primary, Giandomenico, Silvana Di, primary, Ordóñez, Jose Luis, primary, Sevillano, Victoria, primary, Malaguarnera, Roberta, primary, Picci, Piero, primary, Hassan, A. Bass, primary, Alava, Enrique De, primary, D'Incalci, Maurizio, primary, and Scotlandi, Katia, primary

Published
2023
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22. Figure S3 from Combination of PPARγ Agonist Pioglitazone and Trabectedin Induce Adipocyte Differentiation to Overcome Trabectedin Resistance in Myxoid Liposarcomas

Author

Frapolli, Roberta, primary, Bello, Ezia, primary, Ponzo, Marianna, primary, Craparotta, Ilaria, primary, Mannarino, Laura, primary, Ballabio, Sara, primary, Marchini, Sergio, primary, Carrassa, Laura, primary, Ubezio, Paolo, primary, Porcu, Luca, primary, Brich, Silvia, primary, Sanfilippo, Roberta, primary, Casali, Paolo Giovanni, primary, Gronchi, Alessandro, primary, Pilotti, Silvana, primary, and D'Incalci, Maurizio, primary

Published
2023
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23. Supplementary Table 1 from Trabectedin Efficacy in Ewing Sarcoma Is Greatly Increased by Combination with Anti-IGF Signaling Agents

Author

Amaral, Ana Teresa, primary, Garofalo, Cecilia, primary, Frapolli, Roberta, primary, Manara, Maria Cristina, primary, Mancarella, Caterina, primary, Uboldi, Sarah, primary, Giandomenico, Silvana Di, primary, Ordóñez, Jose Luis, primary, Sevillano, Victoria, primary, Malaguarnera, Roberta, primary, Picci, Piero, primary, Hassan, A. Bass, primary, Alava, Enrique De, primary, D'Incalci, Maurizio, primary, and Scotlandi, Katia, primary

Published
2023
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24. Data from Antitumor and Anti-inflammatory Effects of Trabectedin on Human Myxoid Liposarcoma Cells

Author

Germano, Giovanni, primary, Frapolli, Roberta, primary, Simone, Matteo, primary, Tavecchio, Michele, primary, Erba, Eugenio, primary, Pesce, Samantha, primary, Pasqualini, Fabio, primary, Grosso, Federica, primary, Sanfilippo, Roberta, primary, Casali, Paolo G., primary, Gronchi, Alessandro, primary, Virdis, Emanuela, primary, Tarantino, Eva, primary, Pilotti, Silvana, primary, Greco, Angela, primary, Nebuloni, Manuela, primary, Galmarini, Carlos Maria, primary, Tercero, Juan Carlos, primary, Mantovani, Alberto, primary, D'Incalci, Maurizio, primary, and Allavena, Paola, primary

Published
2023
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25. Supplementary Figures 1-6 from Antitumor and Anti-inflammatory Effects of Trabectedin on Human Myxoid Liposarcoma Cells

Author

Germano, Giovanni, primary, Frapolli, Roberta, primary, Simone, Matteo, primary, Tavecchio, Michele, primary, Erba, Eugenio, primary, Pesce, Samantha, primary, Pasqualini, Fabio, primary, Grosso, Federica, primary, Sanfilippo, Roberta, primary, Casali, Paolo G., primary, Gronchi, Alessandro, primary, Virdis, Emanuela, primary, Tarantino, Eva, primary, Pilotti, Silvana, primary, Greco, Angela, primary, Nebuloni, Manuela, primary, Galmarini, Carlos Maria, primary, Tercero, Juan Carlos, primary, Mantovani, Alberto, primary, D'Incalci, Maurizio, primary, and Allavena, Paola, primary

Published
2023
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26. Supplementary Figure Legends 1-6 from Antitumor and Anti-inflammatory Effects of Trabectedin on Human Myxoid Liposarcoma Cells

Author

Germano, Giovanni, primary, Frapolli, Roberta, primary, Simone, Matteo, primary, Tavecchio, Michele, primary, Erba, Eugenio, primary, Pesce, Samantha, primary, Pasqualini, Fabio, primary, Grosso, Federica, primary, Sanfilippo, Roberta, primary, Casali, Paolo G., primary, Gronchi, Alessandro, primary, Virdis, Emanuela, primary, Tarantino, Eva, primary, Pilotti, Silvana, primary, Greco, Angela, primary, Nebuloni, Manuela, primary, Galmarini, Carlos Maria, primary, Tercero, Juan Carlos, primary, Mantovani, Alberto, primary, D'Incalci, Maurizio, primary, and Allavena, Paola, primary

Published
2023
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28. Enhancing Pt(IV) Complexes' Anticancer Activity upon Encapsulation in Stimuli‐Responsive Nanocages

Author

Sancho‐albero, M, Facchetti, G, Panini, N, Meroni, M, Bello, E, Rimoldi, I, Zucchetti, M, Frapolli, R, De Cola, L, Sancho‐Albero, María, Facchetti, Giorgio, Panini, Nicolò, Meroni, Marina, Bello, Ezia, Rimoldi, Isabella, Zucchetti, Massimo, Frapolli, Roberta, De Cola, Luisa, Sancho‐albero, M, Facchetti, G, Panini, N, Meroni, M, Bello, E, Rimoldi, I, Zucchetti, M, Frapolli, R, De Cola, L, Sancho‐Albero, María, Facchetti, Giorgio, Panini, Nicolò, Meroni, Marina, Bello, Ezia, Rimoldi, Isabella, Zucchetti, Massimo, Frapolli, Roberta, and De Cola, Luisa

Abstract

Platinum-based chemotherapy is the first-line treatment for different cancer types, and in particular, for malignant pleural mesothelioma patients (a tumor histotype with urgent medical needs). Herein, a strategy is presented to stabilize, transport, and intracellularly release a platinum(IV) (Pt-IV) prodrug using a breakable nanocarrier. Its reduction, and therefore activation as an anticancer drug, is promoted by the presence of glutathione in neoplastic cells that also causes the destruction of the carrier. The nanocage presents a single internal cavity in which the hydrophobic complex (Pt(dach)Cl-2(OH)(2)), (dach = R,R-diaminocyclohexane) is encapsulated. The in vitro uptake and the internalization kinetics in cancer model cells are evaluated and, using flow cytometry analysis, the successful release and activation of the Pt-based drug inside cancer cells are demonstrated. The in vitro findings are confirmed by the in vivo experiments on a mice model obtained by xenografting MPM487, a patient-derived malignant pleural mesothelioma. MPM487 confirms the well-known resistance of malignant pleural mesothelioma to cisplatin treatment while an interesting 50% reduction of tumor growth is observed when mice are treated with the Pt-IV, entrapped in the nanocages, at an equivalent dose of the platinum complex.

Published
2023

31. Development and Validation of a HPLC–MS/MS Method to Measure Nifuroxazide and Its Application in Healthy and Glioblastoma-Bearing Mice

Author

Ceruti, Tommaso, primary, D’Alessandris, Quintino Giorgio, additional, Frapolli, Roberta, additional, Gopalakrishnan, Jay, additional, Buccarelli, Mariachiara, additional, Meroni, Marina, additional, Lauretti, Liverana, additional, Ricci-Vitiani, Lucia, additional, Pallini, Roberto, additional, and Zucchetti, Massimo, additional

Published
2022
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32. Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth

Author

Germano, Giovanni, Lamba, Simona, Rospo, Giuseppe, Barault, Ludovic, Magrì, Alessandro, Maione, Federica, Russo, Mariangela, Crisafulli, Giovanni, Bartolini, Alice, Lerda, Giulia, Siravegna, Giulia, Mussolin, Benedetta, Frapolli, Roberta, Montone, Monica, Morano, Federica, de Braud, Filippo, Amirouchene-Angelozzi, Nabil, Marsoni, Silvia, D’Incalci, Maurizio, Orlandi, Armando, Giraudo, Enrico, Sartore-Bianchi, Andrea, Siena, Salvatore, Pietrantonio, Filippo, Di Nicolantonio, Federica, and Bardelli, Alberto

Published
2017
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35. Role of Macrophage Targeting in the Antitumor Activity of Trabectedin

Author

Germano, Giovanni, Frapolli, Roberta, Belgiovine, Cristina, Anselmo, Achille, Pesce, Samantha, Liguori, Manuela, Erba, Eugenio, Uboldi, Sarah, Zucchetti, Massimo, Pasqualini, Fabio, Nebuloni, Manuela, van Rooijen, Nico, Mortarini, Roberta, Beltrame, Luca, Marchini, Sergio, Fuso Nerini, Ilaria, Sanfilippo, Roberta, Casali, Paolo G., Pilotti, Silvana, Galmarini, Carlos M., Anichini, Andrea, Mantovani, Alberto, D’Incalci, Maurizio, and Allavena, Paola

Published
2013
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36. Development and Validation of a HPLC–MS/MS Method to Measure Nifuroxazide and Its Application in Healthy and Glioblastoma-Bearing Mice

Author

Ceruti, T, D’Alessandris, Q, Frapolli, R, Gopalakrishnan, J, Buccarelli, M, Meroni, M, Lauretti, L, Ricci-Vitiani, L, Pallini, R, Zucchetti, M, Ceruti, Tommaso, D’Alessandris, Quintino Giorgio, Frapolli, Roberta, Gopalakrishnan, Jay, Buccarelli, Mariachiara, Meroni, Marina, Lauretti, Liverana, Ricci-Vitiani, Lucia, Pallini, Roberto, Zucchetti, Massimo, Ceruti, T, D’Alessandris, Q, Frapolli, R, Gopalakrishnan, J, Buccarelli, M, Meroni, M, Lauretti, L, Ricci-Vitiani, L, Pallini, R, Zucchetti, M, Ceruti, Tommaso, D’Alessandris, Quintino Giorgio, Frapolli, Roberta, Gopalakrishnan, Jay, Buccarelli, Mariachiara, Meroni, Marina, Lauretti, Liverana, Ricci-Vitiani, Lucia, Pallini, Roberto, and Zucchetti, Massimo

Abstract

Nifuroxazide (NAZ), a nitrofuran derivative used to treat diarrhea, has been recently shown to possess anticancer activity. However, its pharmacokinetic profile is poorly known. The pharmacokinetic profile of NAZ was thus investigated in mice using a newly developed method based on high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). We determined the concentrations of NAZ in the plasma and brain tissue of mice treated with the drug. The method proved to be specific, reproducible, precise, and accurate. It also demonstrated high sensitivity, reaching an LOQ in the order of ppb for both matrices, using samples of 100 mu L or 0.2 g. The new HPLC-MS/MS assay was successfully applied to study the pharmacokinetics of NAZ after chronic intraperitoneal administration in mice at a dose of 30 mg/kg. One hour after treatment, plasma concentrations of NAZ were in the range of 336-2640 ng/mL. Moreover, unlike the brains of healthy mice or those with healed mechanical injuries, we found that NAZ was able to cross the injured blood-brain barrier of tumor-infiltrated brains. Thus, following i.p. administration, NAZ reaches systemic levels suitable for testing its efficacy in preclinical models of glioblastoma. Overall, these pharmacokinetic data provide robust evidence supporting the repositioning of NAZ as an antitumor drug.

Published
2022

37. Pharmacokinetics of the combination of trabectedin and pioglitazone in myxoid liposarcoma patient-derived xenograft models

Author

Meroni, M, Ceruti, T, Morosi, L, Matteo, C, Zucchetti, M, Sanfilippo, R, Casali, P, Pilotti, S, D’Incalci, M, Frapolli, R, Meroni, Marina, Ceruti, Tommaso, Morosi, Lavinia, Matteo, Cristina, Zucchetti, Massimo, Sanfilippo, Roberta, Casali, Paolo G, Pilotti, Silvana, D’Incalci, Maurizio, Frapolli, Roberta, Meroni, M, Ceruti, T, Morosi, L, Matteo, C, Zucchetti, M, Sanfilippo, R, Casali, P, Pilotti, S, D’Incalci, M, Frapolli, R, Meroni, Marina, Ceruti, Tommaso, Morosi, Lavinia, Matteo, Cristina, Zucchetti, Massimo, Sanfilippo, Roberta, Casali, Paolo G, Pilotti, Silvana, D’Incalci, Maurizio, and Frapolli, Roberta

Published
2022

41. Corrigendum to “Mechanisms of responsiveness to and resistance against trabectedin in murine models of human myxoid liposarcoma” [Genomics Volume 113, Issue 5, September 2021, Pages 3439–3448]

Author

Mannarino, Laura, primary, Craparotta, Ilaria, additional, Ballabio, Sara, additional, Frapolli, Roberta, additional, Meroni, Marina, additional, Bello, Ezia, additional, Panini, Nicolò, additional, Callari, Maurizio, additional, Sanfilippo, Roberta, additional, Casali, Paolo G., additional, Barisella, Marta, additional, Fabbroni, Chiara, additional, Marchini, Sergio, additional, and D'Incalci, Maurizio, additional

Published
2022
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44. Antiangiogenic activity of trabectedin in myxoid liposarcoma: Involvement of host TIMP-1 and TIMP-2 and tumor thrombospondin-1

Author

Dossi, Romina, Frapolli, Roberta, Di Giandomenico, Silvana, Paracchini, Lara, Bozzi, Fabio, Brich, Silvia, Castiglioni, Vittoria, Borsotti, Patrizia, Belotti, Dorina, Uboldi, Sarah, Sanfilippo, Roberta, Erba, Eugenio, Giavazzi, Raffaella, Marchini, Sergio, Pilotti, Silvana, DʼIncalci, Maurizio, and Taraboletti, Giulia

Published
2015
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48. Additional file 1 of PEGylated recombinant human hyaluronidase (PEGPH20) pre-treatment improves intra-tumour distribution and efficacy of paclitaxel in preclinical models

Author

Morosi, Lavinia, Meroni, Marina, Ubezio, Paolo, Fuso Nerini, Ilaria, Minoli, Lucia, Porcu, Luca, Panini, Nicolò, Colombo, Marika, Blouw, Barbara, Kang, David W., Davoli, Enrico, Zucchetti, Massimo, D’Incalci, Maurizio, and Frapolli, Roberta

Abstract

Additional file 1. Additional methods and results sections.

Published
2021
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49. The Neuroprotective Effect of Erythropoietin in Docetaxel-Induced Peripheral Neuropathy Causes No Reduction of Antitumor Activity in 13762 Adenocarcinoma-Bearing Rats

Author

Cervellini, Ilaria, Bello, Ezia, Frapolli, Roberta, Porretta-Serapiglia, Carla, Oggioni, Norberto, Canta, Annalisa, Lombardi, Raffaella, Camozzi, Francesca, Roglio, Ilaria, Melcangi, Roberto Cosimo, D’incalci, Maurizio, Lauria, Giuseppe, Ghezzi, Pietro, Cavaletti, Guido, and Bianchi, Roberto

Published
2010
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