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17 results on '"Franzosi, L"'

2. SERPINB3 AND TGF-BETA IN CHRONIC LIVER DISEASE

Author

Turato, Cristian, Calabrese, Fiorella, Biasiolo, Alessandra, Quarta, SANTINA MARIA, Ruvoletto, Mariagrazia, Tono, N, Franzosi, L, Paccagnella, D, Fassina, G, Gatta, Angelo, and Pontisso, Patrizia

Published
2009

6. Osteopontin-IgM in the diagnosis of HCC

Author

Biasiolo, A., primary, Tono, N., additional, Franzosi, L., additional, Beneduce, L., additional, Zuin, J., additional, Fassina, G., additional, Meo, S., additional, Paccagnella, D., additional, Mazzucco, M., additional, Farinati, F., additional, Giacomin, A., additional, Vanin, V., additional, Aldinio, M.T., additional, Miola, E., additional, Donà, S., additional, Gatta, A., additional, and Pontisso, P., additional

Published
2009
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8. 300 SERPINB3 AND TGF-β1 CORRELATION IN CHRONIC LIVER DISEASE

Author

Turato, C., primary, Calabrese, F., additional, Biasiolo, A., additional, Quarta, S., additional, Ruvoletto, M., additional, Tono, N., additional, Franzosi, L., additional, Paccagnella, D., additional, Fassina, G., additional, Gatta, A., additional, and Pontisso, P., additional

Published
2009
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9. SERPINB3 and TGF-β1 in chronic liver disease

Author

Turato, C., primary, Calabrese, F., additional, Biasiolo, A., additional, Quarta, S., additional, Ruvoletto, M.G., additional, Tono, N., additional, Franzosi, L., additional, Paccagnella, D., additional, Fassina, G., additional, Gatta, A., additional, and Pontisso, P., additional

Published
2009
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16. Cardiac dysfunction as an early predictor of portal hypertension in chronic hepatitis C.

Author

Marconi C, Bellan M, Giarda P, Minisini R, Favretto S, Burlone ME, Franzosi L, and Pirisi M

Abstract

Background: Cirrhotic cardiomyopathy is characterized by a set of cardiovascular modifications observed in advanced chronic liver disease. The aim of this study was to investigate cardiovascular alterations in chronic liver disease with different stages of fibrosis and to correlate cardiac involvement with endoscopic complications of portal hypertension., Methods: Seventy patients with chronic hepatitis C-related chronic liver disease and 20 sex- and age-matched controls underwent clinical evaluation, hepatic transient elastography, and echocardiography. Forty-nine of the 70 patients underwent an esophagogastroduodenoscopy for screening of esophageal and gastric varices., Results: According to the value of liver stiffness (LS), patients were divided in 2 groups: non-cirrhotics (LS<12.5 kPa; n=30; median LS=8.1 kPa, 95% confidence interval [CI] 6.4-9.2 kPa) and cirrhotics (LS>12.5 kPa; n=40; median LS=19.4 kPa, 95%CI 17-22 kPa). Compared to non-cirrhotics, cirrhotics showed a significant dilatation of the left atrium (P=0.007 and P=0.003 for area and volume index, respectively). In patients with chronic liver disease, peak systolic wave velocity (S¢) measured by tissue Doppler imaging (TDI) was lower (P=0.004), but ejection fraction was not reduced. Left atrial volume, left ventricular mass index and TDI S¢-wave velocity, but not liver stiffness, correlated with endoscopic signs of portal hypertension., Conclusions: Left atrial enlargement and peak S¢-wave systolic velocities are echocardiographic markers of diastolic and systolic dysfunction in liver cirrhosis. Cardiac alterations closely correlate to endoscopic portal hypertension; further studies could elucidate the potential role of echocardiography in the early identification of cirrhotic patients at higher risk for endoscopic complications of portal hypertension., Competing Interests: Conflict of Interest: None

Published
2017
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17. Gas6 as a putative noninvasive biomarker of hepatic fibrosis.

Author

Bellan M, Pogliani G, Marconi C, Minisini R, Franzosi L, Alciato F, Magri A, Avanzi GC, Pirisi M, and Sainaghi PP

Subjects
Aged, Area Under Curve, Elasticity Imaging Techniques, Female, Hepatitis B complications, Hepatitis B diagnosis, Hepatitis B epidemiology, Hepatitis C complications, Hepatitis C diagnosis, Hepatitis C epidemiology, Humans, Liver physiopathology, Liver Cirrhosis etiology, Liver Cirrhosis pathology, Male, Middle Aged, ROC Curve, Sensitivity and Specificity, Biomarkers blood, Intercellular Signaling Peptides and Proteins blood, Liver Cirrhosis diagnosis
Abstract

Aim: To evaluate serum growth arrest-specific gene 6 (Gas6) concentration as a biomarker of liver fibrosis progression., Materials & Methods: One hundred and thirteen consecutive patients affected by chronic liver disease underwent transient elastography, Gas6 measurement and, if clinically indicated, liver biopsy., Results: Gas6 concentration was directly correlated to liver stiffness (r = 0.67; p < 0.0001) and was significantly higher in patients with advanced fibrosis (Ishak 4-5; p < 0.001). A plasma concentration <30 ng/ml Gas6 ruled out fibrosis with 84% sensitivity and 56% specificity, while values >42 ng/ml identified severe fibrosis with a sensitivity of 64% and a specificity of 95%; the diagnostic accuracy was comparable to that of transient elastography., Conclusion: Gas6 is a novel biomarker of liver fibrosis, with a potential clinical and pathophysiological relevance.

Published
2016
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