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4. Nonstandard Errors

Author

MENKVELD, AJ, DREBER, A, HOLZMEISTER, F, HUBER, J, JOHANNESSON, M, KIRCHLER, M, NEUSÜß, S, RAZEN, M, WEITZEL, U, ABAD‐DÍAZ, D, ABUDY, M, MANO, N, MARCHAL, A, MARTINEAU, C, MAZZOLA, F, MELOSO, D, MI, MG, MIHET, R, MOHAN, V, MOINAS, S, ANGEL, JJ, GEMAYEL, R, MOORE, D, MU, L, MURAVYEV, D, MURPHY, D, NESZVEDA, G, NEUMEIER, C, NIELSSON, U, NIMALENDRAN, M, NOLTE, S, NORDEN, LL, GERRITSEN, D, AVETIKIAN, AT, O'NEILL, P, OBAID, K, ØDEGAARD, BA, ÖSTBERG, P, PAGNOTTA, E, PAINTER, M, PALAN, S, PALIT, IJ, PARK, A, GIL‐BAZO, J, PASCUAL, R, BACH, A, PASQUARIELLO, P, PASTOR, L, PATEL, V, PATTON, AJ, PEARSON, ND, PELIZZON, L, PELLI, M, PELSTER, M, GILDER, D, PÉRIGNON, C, PFIFFER, C, BAIDOO, E, PHILIP, R, PLÍHAL, T, PRAKASH, P, PRESS, O, PRODROMOU, T, PROKOPCZUK, M, PUTNINS, T, GLOSTEN, LR, QIAN, Y, RAIZADA, G, RAKOWSKI, D, BAKALLI, G, RANALDO, A, REGIS, L, REITZ, S, RENAULT, T, RENJIE, RW, RENO, R, GOMEZ, T, RIDDIOUGH, SJ, RINNE, K, RINTAMÄKI, P, RIORDAN, R, BAO, L, RITTMANNSBERGER, T, LONGARELA, IR, ROESCH, D, ROGNONE, L, ROSEMAN, B, GORBENKO, A, ROŞU, I, ROY, S, RUDOLF, N, RUSH, SR, RZAYEV, K, BARBON, A, RZEŹNIK, AA, SANFORD, A, SANKARAN, H, SARKAR, A, GRAMMIG, J, SARNO, L, SCAILLET, O, SCHARNOWSKI, S, SCHENK‐HOPPÉ, KR, SCHERTLER, A, SCHNEIDER, M, BASHCHENKO, O, SCHROEDER, F, SCHÜRHOFF, N, SCHUSTER, P, GRÉGOIRE, V, SCHWARZ, MA, SEASHOLES, MS, SEEGER, NJ, SHACHAR, O, SHKILKO, A, SHUI, J, SIKIC, M, BINDRA, PC, SIMION, G, SMALES, LA, GÜÇBILMEZ, U, SÖDERLIND, P, SOJLI, E, SOKOLOV, K, SÖNKSEN, J, SPOKEVICIUTE, L, STEFANOVA, D, SUBRAHMANYAM, MG, SZASZI, B, BJØNNES, GH, TALAVERA, O, ADRIAN, T, TANG, Y, TAYLOR, N, THAM, W, THEISSEN, E, THIMME, J, TONKS, I, TRAN, H, TRAPIN, L, TROLLE, AB, BLACK, JR, HAGSTRÖMER, B, VADUVA, MA, VALENTE, G, VAN NESS, RA, VASQUEZ, A, VEROUSIS, T, VERWIJMEREN, P, VILHELMSSON, A, VILKOV, G, VLADIMIROV, V, VOGEL, S, HAMBUCKERS, J, BLACK, BS, VOIGT, S, WAGNER, W, WALTHER, T, WEISS, P, VAN DER WEL, M, WERNER, IM, WESTERHOLM, PJ, WESTHEIDE, C, WIKA, HC, HAPNES, E, WIPPLINGER, E, BOGOEV, D, WOLF, M, WOLFF, CCP, WOLK, L, WONG, W, WRAMPELMEYER, J, WU, Z, XIA, S, XIU, D, HARRIS, JH, XU, K, XU, C, CORREA, SB, YADAV, PK, YAGÜE, J, YAN, C, YANG, A, YOO, W, YU, W, YU, Y, HARRIS, L, YU, S, YUESHEN, BZ, YUFEROVA, D, BONDARENKO, O, ZAMOJSKI, M, ZAREEI, A, ZEISBERGER, SM, ZHANG, L, ZHANG, SS, ZHANG, X, HARTMANN, S, ZHAO, L, ZHONG, Z, ZHOU, ZI, ZHOU, C, BOS, CS, ZHU, XS, ZOICAN, M, ZWINKELS, R, BOSCH‐ROSA, C, BOURI, E, HASSE, J, BROWNLEES, C, CALAMIA, A, CAO, VN, CAPELLE‐BLANCARD, G, ROMERO, LMC, CAPORIN, M, CARRION, A, CASKURLU, T, CHAKRABARTY, B, CHEN, J, HAUTSCH, N, CHERNOV, M, CHEUNG, W, CHINCARINI, LB, CHORDIA, T, CHOW, S, CLAPHAM, B, COLLIARD, J, COMERTON‐FORDE, C, CURRAN, E, DAO, T, HE, X, DARE, W, DAVIES, RJ, DE BLASIS, R, DE NARD, GF, DECLERCK, F, DEEV, O, DEGRYSE, H, DEKU, SY, DESAGRE, C, VAN DIJK, MA, HEATH, D, DIM, C, DIMPFL, T, DONG, YJ, DRUMMOND, PA, DUDDA, T, DUEVSKI, T, DUMITRESCU, A, DYAKOV, T, DYHRBERG, AH, DZIELIŃSKI, M, AIT‐SAHALIA, Y, EKSI, A, KALAK, IE, ELLEN, ST, EUGSTER, N, EVANS, MDD, FARRELL, M, FELEZ‐VINAS, E, FERRARA, G, FERROUHI, EM, FLORI, A, HEDIGER, S, FLUHARTY‐JAIDEE, JT, FOLEY, SDV, FONG, KYL, FOUCAULT, T, FRANUS, T, FRANZONI, F, FRIJNS, B, FRÖMMEL, M, FU, SM, FÜLLBRUNN, SC, HENDERSHOTT, T, GAN, B, GAO, G, GEHRIG, TP, HIBBERT, AM, HJALMARSSON, E, HOELSCHER, SA, HOFFMANN, P, HOLDEN, CW, HORENSTEIN, AR, HUANG, W, HUANG, D, AKMANSOY, O, HURLIN, C, ILCZUK, K, IVASHCHENKO, A, IYER, SR, JAHANSHAHLOO, H, JALKH, N, JONES, CM, JURKATIS, S, JYLHÄ, P, KAECK, AT, ALCOCK, JT, KAISER, G, KARAM, A, KARMAZIENE, E, KASSNER, B, KAUSTIA, M, KAZAK, E, KEARNEY, F, VAN KERVEL, V, KHAN, SA, KHOMYN, MK, ALEXEEV, V, KLEIN, T, KLEIN, O, KLOS, A, KOETTER, M, KOLOKOLOV, A, KORAJCZYK, RA, KOZHAN, R, KRAHNEN, JP, KUHLE, P, KWAN, A, ALOOSH, A, LAJAUNIE, Q, LAM, FYEC, LAMBERT, M, LANGLOIS, H, LAUSEN, J, LAUTER, T, LEIPPOLD, M, LEVIN, V, LI, Y, LI, H, AMATO, L, LIEW, CY, LINDNER, T, LINTON, O, LIU, J, LIU, A, LLORENTE, G, LOF, M, LOHR, A, LONGSTAFF, F, LOPEZ‐LIRA, A, AMAYA, D, MANKAD, S, MENKVELD, AJ, DREBER, A, HOLZMEISTER, F, HUBER, J, JOHANNESSON, M, KIRCHLER, M, NEUSÜß, S, RAZEN, M, WEITZEL, U, ABAD‐DÍAZ, D, ABUDY, M, MANO, N, MARCHAL, A, MARTINEAU, C, MAZZOLA, F, MELOSO, D, MI, MG, MIHET, R, MOHAN, V, MOINAS, S, ANGEL, JJ, GEMAYEL, R, MOORE, D, MU, L, MURAVYEV, D, MURPHY, D, NESZVEDA, G, NEUMEIER, C, NIELSSON, U, NIMALENDRAN, M, NOLTE, S, NORDEN, LL, GERRITSEN, D, AVETIKIAN, AT, O'NEILL, P, OBAID, K, ØDEGAARD, BA, ÖSTBERG, P, PAGNOTTA, E, PAINTER, M, PALAN, S, PALIT, IJ, PARK, A, GIL‐BAZO, J, PASCUAL, R, BACH, A, PASQUARIELLO, P, PASTOR, L, PATEL, V, PATTON, AJ, PEARSON, ND, PELIZZON, L, PELLI, M, PELSTER, M, GILDER, D, PÉRIGNON, C, PFIFFER, C, BAIDOO, E, PHILIP, R, PLÍHAL, T, PRAKASH, P, PRESS, O, PRODROMOU, T, PROKOPCZUK, M, PUTNINS, T, GLOSTEN, LR, QIAN, Y, RAIZADA, G, RAKOWSKI, D, BAKALLI, G, RANALDO, A, REGIS, L, REITZ, S, RENAULT, T, RENJIE, RW, RENO, R, GOMEZ, T, RIDDIOUGH, SJ, RINNE, K, RINTAMÄKI, P, RIORDAN, R, BAO, L, RITTMANNSBERGER, T, LONGARELA, IR, ROESCH, D, ROGNONE, L, ROSEMAN, B, GORBENKO, A, ROŞU, I, ROY, S, RUDOLF, N, RUSH, SR, RZAYEV, K, BARBON, A, RZEŹNIK, AA, SANFORD, A, SANKARAN, H, SARKAR, A, GRAMMIG, J, SARNO, L, SCAILLET, O, SCHARNOWSKI, S, SCHENK‐HOPPÉ, KR, SCHERTLER, A, SCHNEIDER, M, BASHCHENKO, O, SCHROEDER, F, SCHÜRHOFF, N, SCHUSTER, P, GRÉGOIRE, V, SCHWARZ, MA, SEASHOLES, MS, SEEGER, NJ, SHACHAR, O, SHKILKO, A, SHUI, J, SIKIC, M, BINDRA, PC, SIMION, G, SMALES, LA, GÜÇBILMEZ, U, SÖDERLIND, P, SOJLI, E, SOKOLOV, K, SÖNKSEN, J, SPOKEVICIUTE, L, STEFANOVA, D, SUBRAHMANYAM, MG, SZASZI, B, BJØNNES, GH, TALAVERA, O, ADRIAN, T, TANG, Y, TAYLOR, N, THAM, W, THEISSEN, E, THIMME, J, TONKS, I, TRAN, H, TRAPIN, L, TROLLE, AB, BLACK, JR, HAGSTRÖMER, B, VADUVA, MA, VALENTE, G, VAN NESS, RA, VASQUEZ, A, VEROUSIS, T, VERWIJMEREN, P, VILHELMSSON, A, VILKOV, G, VLADIMIROV, V, VOGEL, S, HAMBUCKERS, J, BLACK, BS, VOIGT, S, WAGNER, W, WALTHER, T, WEISS, P, VAN DER WEL, M, WERNER, IM, WESTERHOLM, PJ, WESTHEIDE, C, WIKA, HC, HAPNES, E, WIPPLINGER, E, BOGOEV, D, WOLF, M, WOLFF, CCP, WOLK, L, WONG, W, WRAMPELMEYER, J, WU, Z, XIA, S, XIU, D, HARRIS, JH, XU, K, XU, C, CORREA, SB, YADAV, PK, YAGÜE, J, YAN, C, YANG, A, YOO, W, YU, W, YU, Y, HARRIS, L, YU, S, YUESHEN, BZ, YUFEROVA, D, BONDARENKO, O, ZAMOJSKI, M, ZAREEI, A, ZEISBERGER, SM, ZHANG, L, ZHANG, SS, ZHANG, X, HARTMANN, S, ZHAO, L, ZHONG, Z, ZHOU, ZI, ZHOU, C, BOS, CS, ZHU, XS, ZOICAN, M, ZWINKELS, R, BOSCH‐ROSA, C, BOURI, E, HASSE, J, BROWNLEES, C, CALAMIA, A, CAO, VN, CAPELLE‐BLANCARD, G, ROMERO, LMC, CAPORIN, M, CARRION, A, CASKURLU, T, CHAKRABARTY, B, CHEN, J, HAUTSCH, N, CHERNOV, M, CHEUNG, W, CHINCARINI, LB, CHORDIA, T, CHOW, S, CLAPHAM, B, COLLIARD, J, COMERTON‐FORDE, C, CURRAN, E, DAO, T, HE, X, DARE, W, DAVIES, RJ, DE BLASIS, R, DE NARD, GF, DECLERCK, F, DEEV, O, DEGRYSE, H, DEKU, SY, DESAGRE, C, VAN DIJK, MA, HEATH, D, DIM, C, DIMPFL, T, DONG, YJ, DRUMMOND, PA, DUDDA, T, DUEVSKI, T, DUMITRESCU, A, DYAKOV, T, DYHRBERG, AH, DZIELIŃSKI, M, AIT‐SAHALIA, Y, EKSI, A, KALAK, IE, ELLEN, ST, EUGSTER, N, EVANS, MDD, FARRELL, M, FELEZ‐VINAS, E, FERRARA, G, FERROUHI, EM, FLORI, A, HEDIGER, S, FLUHARTY‐JAIDEE, JT, FOLEY, SDV, FONG, KYL, FOUCAULT, T, FRANUS, T, FRANZONI, F, FRIJNS, B, FRÖMMEL, M, FU, SM, FÜLLBRUNN, SC, HENDERSHOTT, T, GAN, B, GAO, G, GEHRIG, TP, HIBBERT, AM, HJALMARSSON, E, HOELSCHER, SA, HOFFMANN, P, HOLDEN, CW, HORENSTEIN, AR, HUANG, W, HUANG, D, AKMANSOY, O, HURLIN, C, ILCZUK, K, IVASHCHENKO, A, IYER, SR, JAHANSHAHLOO, H, JALKH, N, JONES, CM, JURKATIS, S, JYLHÄ, P, KAECK, AT, ALCOCK, JT, KAISER, G, KARAM, A, KARMAZIENE, E, KASSNER, B, KAUSTIA, M, KAZAK, E, KEARNEY, F, VAN KERVEL, V, KHAN, SA, KHOMYN, MK, ALEXEEV, V, KLEIN, T, KLEIN, O, KLOS, A, KOETTER, M, KOLOKOLOV, A, KORAJCZYK, RA, KOZHAN, R, KRAHNEN, JP, KUHLE, P, KWAN, A, ALOOSH, A, LAJAUNIE, Q, LAM, FYEC, LAMBERT, M, LANGLOIS, H, LAUSEN, J, LAUTER, T, LEIPPOLD, M, LEVIN, V, LI, Y, LI, H, AMATO, L, LIEW, CY, LINDNER, T, LINTON, O, LIU, J, LIU, A, LLORENTE, G, LOF, M, LOHR, A, LONGSTAFF, F, LOPEZ‐LIRA, A, AMAYA, D, and MANKAD, S

Abstract

ABSTRACTIn statistics, samples are drawn from a population in a data‐generating process (DGP). Standard errors measure the uncertainty in estimates of population parameters. In science, evidence is generated to test hypotheses in an evidence‐generating process (EGP). We claim that EGP variation across researchers adds uncertainty—nonstandard errors (NSEs). We study NSEs by letting 164 teams test the same hypotheses on the same data. NSEs turn out to be sizable, but smaller for more reproducible or higher rated research. Adding peer‐review stages reduces NSEs. We further find that this type of uncertainty is underestimated by participants.

Published
2024

7. Exploring Neurocognitive Deterioration in Alzheimer’s Disease

Author

Franzoni, F., Cammisuli, Davide, Scarfo, G., Castelnuovo, Gianluca, Cammisuli D., Castelnuovo G. (ORCID:0000-0003-2633-9822), Franzoni, F., Cammisuli, Davide, Scarfo, G., Castelnuovo, Gianluca, Cammisuli D., and Castelnuovo G. (ORCID:0000-0003-2633-9822)

Abstract

ageing

Published
2023

8. Engagement in a structured physical activity program and its effects upon health-related quality of life in elderly women: An observational study

Author

Cammisuli, Davide, Franzoni, F., Fusi, J., Scarfo, G., Castelnuovo, Gianluca, Cammisuli D., Castelnuovo G. (ORCID:0000-0003-2633-9822), Cammisuli, Davide, Franzoni, F., Fusi, J., Scarfo, G., Castelnuovo, Gianluca, Cammisuli D., and Castelnuovo G. (ORCID:0000-0003-2633-9822)

Abstract

Aging is a complex process associated with an impairment in functional capacity and low health-related quality of life (HRQoL) due to a high frequency of chronic diseases in the elderly population. Regular physical activity (PA) may limit some physiological effects of sedentary lifestyle and increase life expectancy. An observational was conducted to measure the HRQoL among older adults living in the community, by comparing a convenience sample of elderly females practicing a structured program of PA from 2 to 3 times per week in 60-min sessions (i.e., active females, AFs) to a sample of participants adopting lifestyle behaviors expending little energy (i.e., sedentary females, SFs). A validated questionnaire (the RAND 36-item) was used as outcome measure. All participants were assessed in terms of cognitive status (Montreal Cognitive Assessment, MoCA) to exclude mild cognitive impairment, divided attention/executive functioning (Trail Making Test, Stroop Test) and psychopathological dimensions of anxiety (Geriatric Anxiety Inventory, GAI), and depression (Geriatric Depression Scale, GDS). Non-parametric analysis revealed that AFs and SFs differed significantly in the RAND Energy/Fatigue (E/F), Emotional Wellbeing (EW), and Social Functioning (SoF), that was however influenced by education level. Moreover, E/F and EW were negatively associated to anxiety and depression, while SoF was influenced by divided attention. PA results in a healthful behavior for combating feelings of fatigue and low energy as well as emotional distress that can affect health status perception in older women.

Published
2023

9. A Minireview Exploring the Interplay of the Muscle-Gut-Brain (MGB) Axis to Improve Knowledge on Mental Disorders: Implications for Clinical Neuroscience Research and Therapeutics

Author

Cammisuli, Davide, Fusi, J, Scarfò, G, Daniele, S, Castelnuovo, Gianluca, Franzoni, F, Cammisuli D, Castelnuovo G (ORCID:0000-0003-2633-9822), Cammisuli, Davide, Fusi, J, Scarfò, G, Daniele, S, Castelnuovo, Gianluca, Franzoni, F, Cammisuli D, and Castelnuovo G (ORCID:0000-0003-2633-9822)

Abstract

What benefit might emerge from connecting clinical neuroscience with microbiology and exercise science? What about the influence of the muscle-gut-brain (MGB) axis on mental health? The gut microbiota colonizes the intestinal tract and plays a pivotal role in digestion, production of vitamins and immune system development, but it is also able to exert a particular effect on psychological well-being and appears to play a critical role in regulating several muscle metabolic pathways. Endogenous and exogenous factors may cause dysbiosis, with relevant consequences on the composition and function of the gut microbiota that may also modulate muscle responses to exercise. The capacity of specific psychobiotics in ameliorating mental health as complementary strategies has been recently suggested as a novel treatment for some neuropsychiatric diseases. Moreover, physical exercise can modify qualitative and quantitative composition of the gut microbiota and alleviate certain psychopathological symptoms. In this minireview, we documented evidence about the impact of the MGB axis on mental health, which currently appears to be a possible target in the context of a multidimensional intervention mainly including pharmacological and psychotherapeutic treatments, especially for depressive mood.

Published
2022

10. Intravenous methylprednisolone pulses in hospitalised patients with severe COVID-19 pneumonia, A double-blind, randomised, placebo-controlled trial

Author

Salvarani, C, Massari, M, Costantini, M, Franco Merlo, D, Lucia Mariani, G, Viale, P, Nava, S, Guaraldi, G, Dolci, G, Boni, L, Savoldi, L, Bruzzi, P, Turrà, C, Catanoso, M, Maria Marata, A, Barbieri, C, Valcavi, A, Franzoni, F, Cavuto, S, Mazzi, G, Corsini, R, Trapani, F, Bartoloni, A, Barisione, E, Jole Burastero, G, Pan, A, Inojosa, W, Scala, R, Burattini, C, Luppi, F, Codeluppi, M, Eldin Tarek, K, Cenderello, G, Salio, M, Foti, G, Dongilli, R, Bajocchi, G, Alberto Negri, E, Ciusa, G, Fornaro, G, Bassi, I, Zammarchi, L, Aloè, T, Facciolongo, N, Salvarani, Carlo, Massari, Marco, Costantini, Massimo, Franco Merlo, Domenico, Lucia Mariani, Gabriella, Viale, Pierluigi, Nava, Stefano, Guaraldi, Giovanni, Dolci, Giovanni, Boni, Luca, Savoldi, Luisa, Bruzzi, Paolo, Turrà, Caterina, Catanoso, Mariagrazia, Maria Marata, Anna, Barbieri, Chiara, Valcavi, Annamaria, Franzoni, Francesca, Cavuto, Silvio, Mazzi, Giorgio, Corsini, Romina, Trapani, Fabio, Bartoloni, Alessandro, Barisione, Emanuela, Jole Burastero, Giulia, Pan, Angelo, Inojosa, Walter, Scala, Raffaele, Burattini, Cecilia, Luppi, Fabrizio, Codeluppi, Mauro, Eldin Tarek, Kamal, Cenderello, Giovanni, Salio, Mario, Foti, Giuseppe, Dongilli, Roberto, Bajocchi, Gianluigi, Alberto Negri, Emanuele, Ciusa, Giacomo, Fornaro, Giacomo, Bassi, Ilaria, Zammarchi, Lorenzo, Aloè, Teresita, Facciolongo, Nicola, Salvarani, C, Massari, M, Costantini, M, Franco Merlo, D, Lucia Mariani, G, Viale, P, Nava, S, Guaraldi, G, Dolci, G, Boni, L, Savoldi, L, Bruzzi, P, Turrà, C, Catanoso, M, Maria Marata, A, Barbieri, C, Valcavi, A, Franzoni, F, Cavuto, S, Mazzi, G, Corsini, R, Trapani, F, Bartoloni, A, Barisione, E, Jole Burastero, G, Pan, A, Inojosa, W, Scala, R, Burattini, C, Luppi, F, Codeluppi, M, Eldin Tarek, K, Cenderello, G, Salio, M, Foti, G, Dongilli, R, Bajocchi, G, Alberto Negri, E, Ciusa, G, Fornaro, G, Bassi, I, Zammarchi, L, Aloè, T, Facciolongo, N, Salvarani, Carlo, Massari, Marco, Costantini, Massimo, Franco Merlo, Domenico, Lucia Mariani, Gabriella, Viale, Pierluigi, Nava, Stefano, Guaraldi, Giovanni, Dolci, Giovanni, Boni, Luca, Savoldi, Luisa, Bruzzi, Paolo, Turrà, Caterina, Catanoso, Mariagrazia, Maria Marata, Anna, Barbieri, Chiara, Valcavi, Annamaria, Franzoni, Francesca, Cavuto, Silvio, Mazzi, Giorgio, Corsini, Romina, Trapani, Fabio, Bartoloni, Alessandro, Barisione, Emanuela, Jole Burastero, Giulia, Pan, Angelo, Inojosa, Walter, Scala, Raffaele, Burattini, Cecilia, Luppi, Fabrizio, Codeluppi, Mauro, Eldin Tarek, Kamal, Cenderello, Giovanni, Salio, Mario, Foti, Giuseppe, Dongilli, Roberto, Bajocchi, Gianluigi, Alberto Negri, Emanuele, Ciusa, Giacomo, Fornaro, Giacomo, Bassi, Ilaria, Zammarchi, Lorenzo, Aloè, Teresita, and Facciolongo, Nicola

Abstract

Rationale Pulse glucocorticoid therapy is used in hyperinflammation related to coronavirus disease 2019 (COVID-19). We evaluated the efficacy and safety of pulse intravenous methylprednisolone in addition to standard treatment in COVID-19 pneumonia. Methods In this multicentre, randomised, double-blind, placebo-controlled trial, 304 hospitalised patients with COVID-19 pneumonia were randomised to receive 1 g of methylprednisolone intravenously for three consecutive days or placebo in addition to standard dexamethasone. The primary outcome was the duration of patient hospitalisation, calculated as the time interval between randomisation and hospital discharge without the need for supplementary oxygen. The key secondary outcomes were survival free from invasive ventilation with orotracheal intubation and overall survival. Results Overall, 112 (75.4%) out of 151 patients in the pulse methylprednisolone arm and 111 (75.2%) of 150 in the placebo arm were discharged from hospital without oxygen within 30 days from randomisation. Median time to discharge was similar in both groups (15 days, 95% CI 13.0–17.0 days and 16 days, 95% CI 13.8–18.2 days, respectively; hazard ratio (HR) 0.92, 95% CI 0.71–1.20; p=0.528). No significant differences between pulse methylprednisolone and placebo arms were observed in terms of admission to intensive care unit with orotracheal intubation or death (20.0% versus 16.1%; HR 1.26, 95% CI 0.74–2.16; p=0.176) or overall mortality (10.0% versus 12.2%; HR 0.83, 95% CI 0.42–1.64; p=0.584). Serious adverse events occurred with similar frequency in the two groups. Conclusions Methylprenisolone pulse therapy added to dexamethasone was not of benefit in patients with COVID-19 pneumonia.

Published
2022

33. PCDD/F and dioxin-like PCB minimization: A 13-year experimental study along the flue gas cleaning system of a secondary aluminium refining plant

Author

Collina, E, Bortolami, M, Franzoni, F, Lasagni, M, Piccinelli, E, Pitea, D, COLLINA, ELENA MARIA, LASAGNI, MARINA, PICCINELLI, ELSA, PITEA, DEMETRIO, Collina, E, Bortolami, M, Franzoni, F, Lasagni, M, Piccinelli, E, Pitea, D, COLLINA, ELENA MARIA, LASAGNI, MARINA, PICCINELLI, ELSA, and PITEA, DEMETRIO

Abstract

A 13-years study shows that a careful design of the flue gas cleaning system of a full scale secondary aluminium refining plant results in a minimized and very stable emission of Polychlorinated Dibenzo–p–Dioxins (PCDD), Polychlorinated Dibenzo Furans (PCDF) and dioxin-like Polychlorinated Biphenyls (PCB). The value of equivalent toxicity of PCDD/F in the emission was definitely of an order of magnitude less than the regulation limit. In the initial flue gas cleaning system, the PCB mean fingerprint after the slow cooling of the flue gas was typical of de novo synthesis. Instead, in the presence of quenching, there was evidence that the fast cooling of flue gas prevented the PCB de novo synthesis. In fact, the PCB profile was similar to that in the air collected from the aspiration hoods for the quenching. The gas-phase and solid-phase partitioning of PCBs, before and after the fabric filters, highlights the predominant role of the vapor phase with respect to the total removal efficiency. The polycyclic aromatic hydrocarbons breakdown could be an additional de novo formation pathway even in industrial plants.

Published
2017

36. Prevention of PCDD/F formation and minimization of their emission at the stack of a secondary casting aluminium plant

Author

Piccinelli, E, Pitea, D, Collina, E, Cortili, G, Lasagni, M, Bortolami, M, Franzoni, F, PICCINELLI, ELSA, PITEA, DEMETRIO, COLLINA, ELENA MARIA, CORTILI, GABRIELE, LASAGNI, MARINA, Franzoni, F., Piccinelli, E, Pitea, D, Collina, E, Cortili, G, Lasagni, M, Bortolami, M, Franzoni, F, PICCINELLI, ELSA, PITEA, DEMETRIO, COLLINA, ELENA MARIA, CORTILI, GABRIELE, LASAGNI, MARINA, and Franzoni, F.

Published
2008

42. CXCL10 (alpha) and CCL2 (beta) chemokines in systemic sclerosis--a longitudinal study

Author

Antonelli, A., Ferri, Clodoveo, Fallahi, P., Ferrari, Silvia Martina, Giuggioli, D., Colaci, Michele, Manfredi, Andreina Teresa, Frascerra, S., Franzoni, F., Galetta, F., and Ferrannini, E.

Subjects
Male, Scleroderma, Systemic, Time Factors, systemic sclerosis, CXCL10, chemokines, Middle Aged, Chemokine CXCL10, Disease Progression, Humans, Female, CCL2, Longitudinal Studies, Chemokine CCL2
Abstract

To measure serum levels of CXCL10 and CCL2 chemokines in patients with SSc, and relate the findings to clinical phenotype and disease progression.Serum CXCL10 and CCL2 were assayed in 72 consecutive newly diagnosed SSc patients and in 72 sex- and age-matched controls. In 37 SSc and 37 controls, serum CXCL10 and CCL2 were re-evaluated 5 yrs later.SSc at onset showed significantly higher CXCL10 serum levels than controls (216 +/- 126 vs 92 +/- 53 pg/ml; P0.0001), as well as CCL2 (388 +/- 172 vs 318 +/- 120 pg/ml; P = 0.01). CXCL10 was significantly increased in SSc with interstitial lung involvement or with kidney involvement (P = 0.01 and P = 0.02, respectively). A significant decrease of CXCL10 was observed from the baseline after 5 yrs in SSc (137 +/- 112 vs 270 +/- 122 pg/ml, respectively; P0.0001), while no significant change was observed for CCL2 (418 +/- 176 vs 405 +/- 164 pg/ml; P = NS); the CCL2/CXCL10 ratio significantly increased at the fifth year (1.7 +/- 0.8 vs 3.5 +/- 2.5; P0.0001). No significant variations were observed in controls from the basal to the 5-yr evaluation with regards to CXCL10, CCL2 or CCL2/CXCL10 ratio.Our study demonstrates high serum levels of CXCL10 (Th1) and CCL2 (Th2) chemokines in newly diagnosed SSc. High values of CXCL10 are associated with a more severe clinical phenotype (lung and kidney involvement). CXCL10 declined during the follow-up, while CCL2 remained unmodified, suggesting that the disease progresses from the early Th1 inflammatory condition to the advanced Th2-like stage.

Published
2007

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