Marcella Nebbioso,1,* Federica Franzone,1,* Antonio Greco,1 Magda Gharbiya,1 Vincenza Bonfiglio,2 Antonella Polimeni3 1Department of Sense Organs, Sapienza University of Rome, Rome, 00185, Italy; 2Department of Experimental Biomedicine and Clinical Neuroscience, Ophthalmology Section, University of Palermo, Palermo, 90133, Italy; 3Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, 00185, Italy*These authors contributed equally to this workCorrespondence: Marcella Nebbioso; Federica FranzoneDepartment of Sense Organs, Ocular Electrophysiology Centre, Umberto I Policlinic, Sapienza University of Rome, Viale del Policlinico 155, Rome, 00161, ItalyTel +39/06/49975422Fax +39/06/49975426Email marcella.nebbioso@uniroma1.it; federica.franzone91@gmail.comAbstract: Curcumin belongs to the group of so-called phytocompounds, biologically active molecules produced by plants exerting a beneficial effect on health. Curcumin shows a wide spectrum of different properties, being an anti-inflammatory, antioxidant, antimicrobial and antimutagenic molecule. The purpose of the review is to examine what literature reported on the characteristics of curcumin, particularly, on the beneficial and controversial aspects of this molecule, aiming for a better therapeutic management of retinal diseases. The retina is a constant target of oxidative stress, this tissue being characterized by cells rich in mitochondria and by vessels and being, obviously, continuously reached from photons affecting its layers. Particularly, the retinal ganglion cells and the photoreceptors are extremely sensitive to oxidative stress damage and it is well known that an imbalance in reactive oxygen species is often involved in several retinal diseases, such as uveitis, age-related macular degeneration, diabetic retinopathy, central serous chorioretinopathy, macular edema, retinal ischemia-reperfusion injury, proliferative vitreoretinopathy, hereditary tapeto-retinal degenerations, and retinal and choroidal tumors. To date, several studies suggest that oral treatment with curcumin is generally well tolerated in humans and, in addition, it seems to have no negative effects: therefore, curcumin is a promising candidate as a retinal disease therapy. Unfortunately, the primary limitation of curcumin is represented by its poor bioavailability, in fact only a minimal fraction of this substance can reach the blood stream in the form of a biologically active compound. However, many steps have been made in several fields. In the future, it is expected that the strategies developed until now to allow curcumin to reach the target tissues in adequate concentrations could be ameliorated and, above all, large in vivo studies on humans are needed to demonstrate the total safety of these compounds and their effectiveness in different eye diseases.Keywords: anti-inflammatory proprieties, antioxidant proprieties, exosomes, miRNA, nanosphere, natural compounds