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11. Management of dyslipidaemia in patients with coronary heart disease: Results from the ESC-EORP EUROASPIRE V survey in 27 countries

Author

De Backer, G., Jankowski, P., Kotseva, K., Mirrakhimov, E., Reiner, Z., Rydén, L., Tokgözoğlu, L., Wood, D., De Bacquer, D., Abreu, A., Aguiar, C., Badariene, J., Bruthans, J., Castro Conde, A., Cifkova, R., Crowley, J., Davletov, K., Bacquer, D. De, De Smedt, D., De Sutter, J., Deckers, J.W., Dilic, M., Dolzhenko, M., Druais, H., Dzerve, V., Erglis, A., Fras, Z., Gaita, D., Gotcheva, N., Grobbee, D.E., Gyberg, V., Hasan Ali, H., Heuschmann, P., Hoes, A.W., Lalic, N., Lehto, S., Lovic, D., Maggioni, A.P., Mancas, S., Marques-Vidal, P., Mellbin, L., Miličić, D., Oganov, R., Pogosova, N., Reiner, Ž., Stagmo, M., Störk, S., Sundvall, J., Tsioufis, K., Vulic, D., Wood, D.A., Jennings, C., Adamska, A., Adamska, S., Tuomilehto, J., Schnell, O., Fiorucci, E., Glemot, M., Larras, F., Missiamenou, V., Maggioni, A., Taylor, C., Ferreira, T., Lemaitre, K., Raman, L., DeSmedt, D., Willems, A.M., De Pauw, M., Vervaet, P., Bollen, J., Dekimpe, E., Mommen, N., Van Genechten, G., Dendale, P., Bouvier, C.A., Chenu, P., Huyberechts, D., Persu, A., Begic, A., Durak Nalbantic, A., Dzubur, A., Hadzibegic, N., Iglica, A., Kapidjic, S., Osmanagic Bico, A., Resic, N., Sabanovic Bajramovic, N., Zvizdic, F., Kovacevic-Preradovic, T., Popovic-Pejicic, S., Djekic, D., Gnjatic, T., Knezevic, T., Kos, Lj, Stanetic, B., Topic, G., Georgiev, Borislav, Terziev, A., Vladimirov, G., Angelov, A., Kanazirev, B., Nikolaeva, S., Tonkova, D., Vetkova, M., Milicic, D., Bosnic, A., Dubravcic, M., Glavina, M., Mance, M., Pavasovic, S., Samardzic, J., Batinic, T., Crljenko, K., Delic-Brkljacic, D., Dula, K., Golubic, K., Klobucar, I., Kordic, K., Kos, N., Nedic, M., Olujic, D., Sedinic, V., Blazevic, T., Pasalic, A., Percic, M., Sikic, J., Cífková, R., Hašplová, K., Šulc, P., Wohlfahrt, P., Mayer, O., Jr., Cvíčela, M., Filipovský, J., Gelžinský, J., Hronová, M., Hasan-Ali, H., Bakery, S., Mosad, E., Hamed, H.B., Ibrahim, A., Elsharef, M.A., Kholef, E.F., Shehata, A., Youssef, M., Elhefny, E., Farid, H., Moustafa, T.M., Sobieh, M.S., Kabil, H., Abdelmordy, A., Kiljander, E., Kiljander, P., Koukkunen, H., Mustonen, J., Cremer, C., Frantz, S., Haupt, A., Hofmann, U., Ludwig, K., Melnyk, H., Noutsias, M., Karmann, W., Prondzinsky, R., Herdeg, C., Hövelborn, T., Daaboul, A., Geisler, T., Keller, T., Sauerbrunn, D., Walz-Ayed, M., Ertl, G., Leyh, R., Ehlert, T., Klocke, B., Krapp, J., Ludwig, T., Käs, J., Starke, C., Ungethüm, K., Wagner, M., Wiedmann, S., Tolis, P., Vogiatzi, G., Sanidas, E., Tsakalis, K., Kanakakis, J., Koutsoukis, A., Vasileiadis, K., Zarifis, J., Karvounis, C., Gibson, I., Houlihan, A., Kelly, C., O'Donnell, M., Bennati, M., Cosmi, F., Mariottoni, B., Morganti, M., Cherubini, A., Di Lenarda, A., Radini, D., Ramani, F., Francese, M.G., Gulizia, M.M., Pericone, D., Aigerim, K., Zholdin, B., Amirov, B., Assembekov, B., Chernokurova, E., Ibragimova, F., Kodasbayev, A., Markova, A., Asanbaev, A., Toktomamatov, U., Tursunbaev, M., Zakirov, U., Abilova, S., Arapova, R., Bektasheva, E., Esenbekova, J., Neronova, K., Baigaziev, K., Baitova, G., Zheenbekov, T., Andrejeva, T., Bajare, I., Kucika, G., Labuce, A., Putane, L., Stabulniece, M., Klavins, E., Sime, I., Gedvilaite, L., Pečiuraite, D., Sileikienė, V., Skiauteryte, E., Solovjova, S., Sidabraite, R., Briedis, K., Ceponiene, I., Jurenas, M., Kersulis, J., Martinkute, G., Vaitiekiene, A., Vasiljevaite, K., Veisaite, R., Plisienė, J., Šiurkaitė, V., Vaičiulis, Ž., Czarnecka, D., Kozieł, P., Podolec, P., Nessler, J., Gomuła, P., Mirek-Bryniarska, E., Bogacki, P., Wiśniewski, A., Pająk, A., Wolfshaut-Wolak, R., Bućko, J., Kamiński, K., Łapińska, M., Paniczko, M., Raczkowski, A., Sawicka, E., Stachurska, Z., Szpakowicz, M., Musiał, W., Dobrzycki, S., Bychowski, J., Kosior, D.A., Krzykwa, A., Setny, M., Rak, A., Gąsior, Z., Haberka, M., Szostak-Janiak, K., Finik, M., Liszka, J., Botelho, A., Cachulo, M., Sousa, J., Pais, A., Durazzo, A., Matos, D., Gouveia, R., Rodrigues, G., Strong, C., Guerreiro, R., Aguiar, J., Cruz, M., Daniel, P., Morais, L., Moreira, R., Rosa, S., Rodrigues, I., Selas, M., Apostu, A., Cosor, O., Gaita, L., Giurgiu, L., Hudrea, C., Maximov, D., Moldovan, B., Mosteoru, S., Pleava, R., Ionescu, M., Parepa, I., Arutyunov, A., Ausheva, A., Isakova, S., Karpova, A., Salbieva, A., Sokolova, O., Vasilevsky, A., Pozdnyakov, Y., Antropova, O., Borisova, L., Osipova, I., Aleksic, M., Crnokrak, B., Djokic, J., Hinic, S., Vukasin, T., Zdravkovic, M., Lalic, N.M., Jotic, A., Lalic, K., Lukic, L., Milicic, T., Macesic, M., Stanarcic Gajovic, J., Stoiljkovic, M., Djordjevic, D., Kostic, S., Tasic, I., Vukovic, A., Jug, B., Juhant, A., Krt, A., Kugonjič, U., Chipayo Gonzales, D., Gómez Barrado, J.J., Kounka, Z., Marcos Gómez, G., Mogollón Jiménez, M.V., Ortiz Cortés, C., Perez Espejo, P., Porras Ramos, Y., Colman, R., Delgado, J., Otero, E., Pérez, A., Fernández-Olmo, M.R., Torres-LLergo, J., Vasco, C., Barreñada, E., Botas, J., Campuzano, R., González, Y., Rodrigo, M., de Pablo, C., Velasco, E., Hernández, S., Lozano, C., González, P., Castro, A., Dalmau, R., Hernández, D., Irazusta, F.J., Vélez, A., Vindel, C., Gómez-Doblas, J.J., García Ruíz, V., Gómez, L., Gómez García, M, Jiménez-Navarro, M., Molina Ramos, A., Marzal, D., Martínez, G., Lavado, R., Vidal, A., Boström-Nilsson, V., Kjellström, B., Shahim, B., Smetana, S., Hansen, O., Stensgaard-Nake, E., Klijn, A.J., Mangus, T.J.P., Peters, R.J.G., Scholte op Reimer, W., Snaterse, M., Aydoğdu, S., Ç Erol, Otürk, S., Tulunay Kaya, C., Ahmetoğlu, Y., Ergene, O., Akdeniz, B., Çırgamış, D., Akkoyun H Kültürsay, S., Kayıkçıoğlu, M., Çatakoğlu, A.B., Çengel, A., Koçak, A.A., Ağırbaşlı, M.A., Açıksarı, G., Çekin, M.E., Kaya, E.B., Koçyiğit, D., Öngen, Z., Özmen, E., Sansoy, V., Kaya, A., Oktay, V., Temizhan, A., Ünal, S., İ Yakut, Kalkan, A.K., Bozkurt, E., Kasapkara, H.A., Faradzh, C., Hrubyak, L., Konoplianyk, L., Kozhuharyova, N., Lobach, L., Nesukai, V., Nudchenko, O., Simagina, T., Yakovenko, L., Azarenko, V., Potabashny, V., Bazylevych, A., Bazylevych, M., Kaminska, K., Panchenko, L., Shershnyova, O., Ovrakh, T., Serik, S., Kolesnik, T., Kosova, H., Hoye P Atkin, A., Fellowes, D., Lindsay, S., Atkinson, C., Kranilla, C., Vinod, M., Beerachee, Y., Bennett, C., Broome, M., Bwalya, A., Caygill, Lindsay, Dinning, L., Gillespie, A., Goodfellow, R., Guy, J., Idress, T., Mills, C., Morgan, C., Oustance, N., Singh, N., Yare, M., Jagoda, J.M., Bowyer, H., Christenssen, V., Groves, A., Jan, A., Riaz, A., Gill, M., Sewell, T.A., Gorog, D., Baker, M., De Sousa, P., Mazenenga, T., Porter, J., Haines, F., Peachey, T., Taaffe, J., Wells, K., Ripley, D.P., Forward, H., McKie, H., Pick, S.L., Thomas, H.E., Batin, P.D., Exley, D., Rank, T., Wright, J., Kardos, A., Sutherland, S.-B., Wren, L., Leeson, P., Barker, D., Moreby, B., Sawyer, J., Stirrup, J., Brunton, M., Brodison, A., Craig, J., Peters, S., Kaprielian, R., Bucaj, A., Mahay, K., Oblak, M., Gale, C., Pye, M., McGill, Y., Redfearn, H., Fearnley, M., De Backer, Guy, Jankowski, Piotr, Kotseva, Kornelia, Mirrakhimov, Erkin, Reiner, Željko, Rydén, Lars, Tokgözoğlu, Lale, Wood, David, and De Bacquer, Dirk

Published
2019
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16. Sex and marital status modify the effect of remote patient management on mortality risk in patients hospitalized for acute systolic heart failure: Insights from the E-INH study

Author

Kerwagen, F, primary, Sehner, S, additional, Albert, J, additional, Morbach, C, additional, Gueder, G, additional, Sahiti, F, additional, Cejka, V, additional, Scholz, N, additional, Frantz, S, additional, Ertl, G, additional, Angermann, C E, additional, and Stoerk, S, additional

Published
2023
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19. Real-world drug prescription patterns and mortality risk in patients hospitalized with acute heart hailure: impact of multimorbidity and heart failure phenotype

Author

Angermann, C, primary, Morbach, C, additional, Gueder, G, additional, Albert, J, additional, Stefenelli, U, additional, Troebs, S O, additional, Stuermlinger, A, additional, Hanke, M, additional, Scholz, N, additional, Cejka, V, additional, Frantz, S, additional, Ertl, G, additional, Stoerk, S, additional, and Angermann, C E, additional

Published
2023
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21. Differences in obstetrical care and outcomes associated with the proportion of the obstetrician’s shift completed

Author

Mallett, G., Grobman, W., Ramos-Brinson, M., Roy, A., Stein, L., Campbell, P., Collins, C., Jackson, N., Dinsmoor, M., Senka, J., Paychek, K., Peaceman, A., Talucci, M., Zylfijaj, M., Reid, Z., Leed, R., Benson, J., Forester, S., Kitto, C., Davis, S., Falk, M., Perez, C., Hill, K., Sowles, A., Postma, J., Alexander, S., Andersen, G., Scott, V., Morby, V., Jolley, K., Miller, J., Berg, B., Dorman, K., Mitchell, J., Kaluta, E., Clark, K., Spicer, K., Timlin, S., Wilson, K., Moseley, L., Leveno, K., Santillan, M., Price, J., Buentipo, K., Bludau, V., Thomas, T., Fay, L., Melton, C., Kingsbery, J., Benezue, R., Simhan, H., Bickus, M., Fischer, D., Kamon, T., DeAngelis, D., Mercer, B., Milluzzi, C., Dalton, W., Dotson, T., McDonald, P., Brezine, C., McGrail, A., Latimer, C., Guzzo, L., Johnson, F., Gerwig, L., Fyffe, S., Loux, D., Frantz, S., Cline, D., Wylie, S., Iams, J., Wallace, M., Northen, A., Grant, J., Colquitt, C., Rouse, D., Andrews, W., Moss, J., Salazar, A., Acosta, A., Hankins, G., Hauff, N., Palmer, L., Lockhart, P., Driscoll, D., Wynn, L., Sudz, C., Dengate, D., Girard, C., Field, S., Breault, P., Smith, F., Annunziata, N., Allard, D., Silva, J., Gamage, M., Hunt, J., Tillinghast, J., Corcoran, N., Jimenez, M., Ortiz, F., Givens, P., Rech, B., Moran, C., Hutchinson, M., Spears, Z., Carreno, C., Heaps, B., Zamora, G., Seguin, J., Rincon, M., Snyder, J., Farrar, C., Lairson, E., Bonino, C., Smith, W., Beach, K., Van Dyke, S., Butcher, S., Thom, E., Rice, M., Zhao, Y., Momirova, V., Palugod, R., Reamer, B., Larsen, M., Spong, C., Tolivaisa, S., VanDorsten, J.P., Yee, Lynn M., McGee, Paula, Bailit, Jennifer L., Wapner, Ronald J., Varner, Michael W., Thorp, John M., Jr., Caritis, Steve N., Prasad, Mona, Tita, Alan T.N., Saade, George R., Sorokin, Yoram, Rouse, Dwight J., Blackwell, Sean C., and Tolosa, Jorge E.

Published
2021
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22. Cervical length distribution and other sonographic ancillary findings of singleton nulliparous patients at midgestation

Author

Peaceman, A., Dinsmoor, M., Mallett, G., Senka, J., Johnson, F., Iams, J., Cline, D., Latimer, C., Frantz, S., Fyffe, S., Shubert, P., Gerwig, L., Milluzzi, C., Dalton, W., Russo, J., Myers, S., Waters, T., Dotson, T., Andrews, W., Northen, A., Sheppard, J., Grant, J., Rouse, D., Allard, D., Hunt, J., Tillinghast, J., Bethelemy, M., Gardner, D., Duquette, C., Hauff, N., Norman, G., King, M., Allen, D., Smith, T., Miller, R., Bousleiman, S., Plante, L., Tocci, C., Ranzini, A., Lake, M., Hoffman, M., Lynch, S., Dashe, J., Leveno, K., Moseley, L., Kingsbery, J., Bludau, V., Benezue, R., Ortiz, F., Givens, P., Rech, B., Moran, C., Reed, P., Hill, K., Varner, M.W., Esplin, M.S., Weaver, A., Alexander, S., Thompson-Garbrecht, D., Miller, J., Acosta, R., Flores, C., Ricon, M., Smith, W., Butcher, S., Segel, S., Pereira, L., Dorman, K., Pena-Centeno, K., Clark, K., Timlin, S., Birkland, M.H., Simhan, H., Cotroneo, P., Zubic, R., Nowinski, D., Thom, E., Gilbert, S., Lozitska, A., Spong, C., Tolivaisa, S., VanDorsten, J.P., Costantine, Maged M., Ugwu, Lynda, Grobman, William A., Mercer, Brian M., Tita, Alan T.N., Rouse, Dwight J., Sorokin, Yoram, Wapner, Ronald J., Blackwell, Sean C., Tolosa, Jorge E., Thorp, John M., and Caritis, Steve N.

Published
2021
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28. Kommentar zu den Leitlinien (2019) der European Society of Cardiology (ESC) zu „Diabetes, Prädiabetes und kardiovaskuläre Erkrankungen“

Author

Marx, N., Frantz, S., Gitt, A. K., and Zirlik, A.

Abstract

Die neuen ESC(European Society of Cardiology)-Leitlinien „Diabetes, Prädiabetes und kardiovaskuläre Erkrankungen“, die in Zusammenarbeit der ESC mit der European Association for the Study of Diabetes (EASD) erstellt wurden, sind eine Weiterentwicklung der 2013 veröffentlichten Leitlinien. In die aktuelle Version von 2019 sind die in den letzten Jahren veröffentlichten Daten aus großen kardiovaskulären Endpunktstudien mit neuen antidiabetisch wirksamen Substanzen eingeflossen und haben zu einer völlig neuen Positionierung von blutzuckersenkenden Medikamenten in der Reduktion kardiovaskulärer Ereignisse bei Patienten mit Diabetes mellitus geführt.

Published
2024
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36. Secondary prevention in diabetic and nondiabetic coronary heart disease patients: Insights from the German subset of the hospital arm of the EUROASPIRE IV and V surveys

Author

Ungethüm, K., primary, Wiedmann, S., additional, Wagner, M., additional, Leyh, R., additional, Ertl, G., additional, Frantz, S., additional, Geisler, T., additional, Karmann, W., additional, Prondzinsky, R., additional, Herdeg, C., additional, Noutsias, M., additional, Ludwig, T., additional, Käs, J., additional, Klocke, B., additional, Krapp, J., additional, Wood, D., additional, Kotseva, K., additional, Störk, S., additional, and Heuschmann, P. U., additional

Published
2022
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37. Evaluation of delivery options for second-stage events

Author

Bailit, Jennifer L., Grobman, William A., Rice, Madeline Murguia, Wapner, Ronald J., Reddy, Uma M., Varner, Michael W., Thorp, John M., Jr., Caritis, Steve N., Iams, Jay D., Saade, George, Rouse, Dwight J., Tolosa, Jorge E., Talucci, M., Zylfijaj, M., Reid, Z., Leed, R., Benson, J., Forester, S., Kitto, C., Davis, S., Falk, M., Perez, C., Hill, K., Sowles, A., Postma, J., Alexander, S., Andersen, G., Scott, V., Morby, V., Jolley, K., Miller, J., Berg, B., Dorman, K., Mitchell, J., Kaluta, E., Clark, K., Spicer, K., Timlin, S., Wilson, K., Leveno, K., Moseley, L., Santillan, M., Price, J., Buentipo, K., Bludau, V., Thomas, T., Fay, L., Melton, C., Kingsbery, J., Benezue, R., Simhan, H., Bickus, M., Fischer, D., Kamon, T., DeAngelis, D., Mercer, B., Milluzzi, C., Dalton, W., Dotson, T., McDonald, P., Brezine, C., McGrail, A., Latimer, C., Guzzo, L., Johnson, F., Gerwig, L., Fyffe, S., Loux, D., Frantz, S., Cline, D., Wylie, S., Iams, J., Tita, A., Wallace, M., Northen, A., Grant, J., Colquitt, C., Rouse, D., Andrews, W., Mallett, G., Ramos-Brinson, M., Roy, A., Stein, L., Campbell, P., Collins, C., Jackson, N., Dinsmoor, M., Senka, J., Paychek, K., Peaceman, A., Moss, J., Salazar, A., Acosta, A., Hankins, G., Sorokin, Y., Hauff, N., Palmer, L., Lockhart, P., Driscoll, D., Wynn, L., Sudz, C., Dengate, D., Girard, C., Field, S., Breault, P., Smith, F., Annunziata, N., Allard, D., Silva, J., Gamage, M., Hunt, J., Tillinghast, J., Corcoran, N., Jimenez, M., Blackwell, S., Ortiz, F., Givens, P., Rech, B., Moran, C., Hutchinson, M., Spears, Z., Carreno, C., Heaps, B., Zamora, G., Seguin, J., Rincon, M., Snyder, J., Farrar, C., Lairson, E., Bonino, C., Smith, W., Beach, K., Van Dyke, S., Butcher, S., Thom, E., Zhao, Y., McGee, P., Momirova, V., Palugod, R., Reamer, B., Larsen, M., Williams, T., Swartz, C., Bhandaru, V., Spong, C., Tolivaisa, S., and VanDorsten, J. P.

Published
2016
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38. Neonatal outcomes of elective early-term births after demonstrated fetal lung maturity

Author

Wallace, M., Northen, A., Grant, J., Colquitt, C., Mallett, G., Ramos-Brinson, M., Roy, A., Stein, L., Campbell, P., Collins, C., Jackson, N., Dinsmoor, M., Senka, J., Paychek, K., Peaceman, A., Talucci, M., Zylfijaj, M., Reid, Z., Leed, R., Benson, J., Forester, S., Kitto, C., Davis, S., Falk, M., Perez, C., Hill, K., Sowles, A., Postma, J., Alexander, S., Andersen, G., Scott, V., Morby, V., Jolley, K., Miller, J., Berg, B., Dorman, K., Mitchell, J., Kaluta, E., Clark, K., Spicer, K., Timlin, S., Wilson, K., Moseley, L., Santillan, M., Price, J., Buentipo, K., Bludau, V., Thomas, T., Fay, L., Melton, C., Kingsbery, J., Benezue, R., Simhan, H., Bickus, M., Fischer, D., Kamon, T., DeAngelis, D., Mercer, B., Milluzzi, C., Dalton, W., Dotson, T., McDonald, P., Brezine, C., McGrail, A., Latimer, C., Guzzo, L., Johnson, F., Gerwig, L., Fyffe, S., Loux, D., Frantz, S., Cline, D., Wylie, S., Shubert, P., Moss, J., Salazar, A., Acosta, A., Hankins, G., Hauff, N., Palmer, L., Lockhart, P., Driscoll, D., Wynn, L., Sudz, C., Dengate, D., Girard, C., Field, S., Breault, P., Smith, F., Annunziata, N., Allard, D., Silva, J., Gamage, M., Hunt, J., Tillinghast, J., Corcoran, N., Jimenez, M., Ortiz, F., Givens, P., Rech, B., Moran, C., Hutchinson, M., Spears, Z., Carreno, C., Heaps, B., Zamora, G., Seguin, J., Rincon, M., Snyder, J., Farrar, C., Lairson, E., Bonino, C., Smith, W., Beach, K., Van Dyke, S., Butcher, S., Thom, E., Zhao, Y., McGee, P., Momirova, V., Palugod, R., Reamer, B., Larsen, M., Spong, C., Tolivaisa, S., VanDorsten, J.P., Tita, Alan T.N., Jablonski, Kathleen A., Bailit, Jennifer L., Grobman, William A., Wapner, Ronald J., Reddy, Uma M., Varner, Michael W., Thorp, John M., Jr., Leveno, Kenneth J., Caritis, Steve N., Iams, Jay D., Saade, George, Sorokin, Yoram, Rouse, Dwight J., Blackwell, Sean C., and Tolosa, Jorge E.

Published
2018
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39. Left ventricular remodelling post-myocardial infarction: pathophysiology, imaging, and novel therapies

Author

Frantz, S., Hundertmark, M.J., Schulz-Menger, J., Bengel, F.M., and Bauersachs, J.

Subjects
Cardiovascular and Metabolic Diseases
Abstract

Most patients survive acute myocardial infarction (MI). Yet this encouraging development has certain drawbacks: heart failure (HF) prevalence is increasing and patients affected tend to have more comorbidities worsening economic strain on healthcare systems and impeding effective medical management. The heart's pathological changes in structure and/or function, termed myocardial remodelling, significantly impact on patient outcomes. Risk factors like diabetes, chronic obstructive pulmonary disease, female sex, and others distinctly shape disease progression on the 'road to HF'. Despite the availability of HF drugs that interact with general pathways involved in myocardial remodelling, targeted drugs remain absent, and patient risk stratification is poor. Hence, in this review, we highlight the pathophysiological basis, current diagnostic methods and available treatments for cardiac remodelling following MI. We further aim to provide a roadmap for developing improved risk stratification and novel medical and interventional therapies.

Published
2022

42. List of Contributors

Author

Abdi, M.M., primary, Al-Humadi, N.H., additional, Amuzie, C.J., additional, Arnold, S.M., additional, Attar, M., additional, Aulbach, A.D., additional, Baird, T.J., additional, Brassard, J.A., additional, Chang, T.T.A., additional, Colagiovanni, D.B., additional, Colerangle, J.B., additional, Collins, R., additional, Dalton, J.A., additional, Denny, K.H., additional, Dietert, R.R., additional, Duncan, J.N., additional, Faqi, A.S., additional, Farmer, J.T., additional, Ferrell Ramos, M., additional, Forbes, P.D., additional, Frantz, S., additional, Freshwater, L., additional, Fuchs, T.C., additional, Gauvin, D.V., additional, Goud, N.S., additional, Green, M.D., additional, Guo, L., additional, Henry, S.P., additional, Hewitt, P.G., additional, Hoberman, A., additional, Hui, J.Y., additional, Johnson, C., additional, Kille, J.W., additional, Kim, A.S., additional, Kim, T.W., additional, Koch, E., additional, Kornbrust, D., additional, Learn, D.B., additional, Lewis, E., additional, Matsumoto, S., additional, McCormick, D.L., additional, Mendes, O.R., additional, Meyer-Tamaki, K.B., additional, Mikaelian, I., additional, Milburn, M.V., additional, Nicolette, J., additional, Nugent, P., additional, Oh, H.H., additional, Oyejide, L., additional, Plassmann, S., additional, Regal, K., additional, Rehagen, D., additional, Resendez, J.C., additional, Rowlands, J.C., additional, Ryals, J.A., additional, Sambuco, C.P., additional, Schrag, M., additional, Settivari, R.S., additional, Slauter, R., additional, Spencer, P.J., additional, Stern, M.E., additional, Stewart, C.W., additional, Stump, D., additional, Surapaneni, S., additional, Templin, M., additional, Truisi, G.L., additional, Vangyi, C., additional, Vidmar, T., additional, Vrbanac, J., additional, Wang, Z.J., additional, Whiteley, L.O., additional, Wilson, D.M., additional, Yan, J.S., additional, York, M.J., additional, and Younis, H.S., additional

Published
2017
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45. Abstract No. 196 Overall survival and toxicities of advanced hepatocellular carcinoma (HCC) Barcelona clinic liver cancer C (BCLC-C) patients following Y-90 radioembolization: assessment from the RESiN Registry (NCT: 02685631)

Author

Goswami, P., primary, Adeniran, O., additional, Frantz, S., additional, Matsuoka, L., additional, Du, L., additional, Gandhi, R., additional, Collins, Z., additional, Matrana, M., additional, Petroziello, M., additional, Brower, J., additional, Sze, D., additional, Kennedy, A., additional, Golzarian, J., additional, Wang, E., additional, and Brown, D., additional

Published
2022
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46. Abstract No. 10 Six-year evaluation of same-day discharge following conventional transarterial chemoembolization (cTACE) of hepatocellular carcinoma (HCC)

Author

Frantz, S., primary, Wu, H., additional, Adeniran, O., additional, Wong, T., additional, Borgmann, T., additional, Matsuoka, L., additional, Geevarghese, S., additional, Alexopoulos, S., additional, Shingina, A., additional, Meranze, S., additional, Baker, J., additional, Garbett, S., additional, and Brown, D., additional

Published
2022
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47. Defining failed induction of labor

Author

Mallett, G., Ramos-Brinson, M., Roy, A., Stein, L., Campbell, P., Collins, C., Jackson, N., Dinsmoor, M., Senka, J., Paychek, K., Peaceman, A., Talucci, M., Zylfijaj, M., Reid, Z., Leed, R., Benson, J., Forester, S., Kitto, C., Davis, S., Falk, M., Perez, C., Hill, K., Sowles, A., Postma, J., Alexander, S., Andersen, G., Scott, V., Morby, V., Jolley, K., Miller, J., Berg, B., Dorman, K., Mitchell, J., Kaluta, E., Clark, K., Spicer, K., Timlin, S., Wilson, K., Moseley, L., Santillan, M., Price, J., Buentipo, K., Bludau, V., Thomas, T., Fay, L., Melton, C., Kingsbery, J., Benezue, R., Simhan, H., Bickus, M., Fischer, D., Kamon, T., DeAngelis, D., Mercer, B., Milluzzi, C., Dalton, W., Dotson, T., McDonald, P., Brezine, C., McGrail, A., Latimer, C., Guzzo, L., Johnson, F., Gerwig, L., Fyffe, S., Loux, D., Frantz, S., Cline, D., Wylie, S., Iams, J., Wallace, M., Northen, A., Grant, J., Colquitt, C., Rouse, D., Andrews, W., Moss, J., Salazar, A., Acosta, A., Hankins, G., Hauff, N., Palmer, L., Lockhart, P., Driscoll, D., Wynn, L., Sudz, C., Dengate, D., Girard, C., Field, S., Breault, P., Smith, F., Annunziata, N., Allard, D., Silva, J., Gamage, M., Hunt, J., Tillinghast, J., Corcoran, N., Jimenez, M., Ortiz, F., Givens, P., Rech, B., Moran, C., Hutchinson, M., Spears, Z., Carreno, C., Heaps, B., Zamora, G., Seguin, J., Rincon, M., Snyder, J., Farrar, C., Lairson, E., Bonino, C., Smith, W., Beach, K., Van Dyke, S., Butcher, S., Thom, E., Rice, M., Zhao, Y., McGee, P., Momirova, V., Palugod, R., Reamer, B., Larsen, M., Spong, C., Tolivaisa, S., Van Dorsten, J.P., Grobman, William A., Bailit, Jennifer, Lai, Yinglei, Reddy, Uma M., Wapner, Ronald J., Varner, Michael W., Thorp, John M., Jr., Leveno, Kenneth J., Caritis, Steve N., Prasad, Mona, Tita, Alan T.N., Saade, George, Sorokin, Yoram, Rouse, Dwight J., Blackwell, Sean C., and Tolosa, Jorge E.

Published
2018
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48. Stroke genetics informs drug discovery and risk prediction across ancestries

Author

Mishra, A, Malik, R, Hachiya, T, Jurgenson, T, Namba, S, Posner, DC, Kamanu, FK, Koido, M, Le Grand, Q, Shi, M, He, Y, Georgakis, MK, Caro, I, Krebs, K, Liaw, Y-C, Vaura, FC, Lin, K, Winsvold, BS, Srinivasasainagendra, V, Parodi, L, Bae, H-J, Chauhan, G, Chong, MR, Tomppo, L, Akinyemi, R, Roshchupkin, GV, Habib, N, Jee, YH, Thomassen, JQ, Abedi, V, Carcel-Marquez, J, Nygaard, M, Leonard, HL, Yang, C, Yonova-Doing, E, Knol, MJ, Lewis, AJ, Judy, RL, Ago, T, Amouyel, P, Armstrong, ND, Bakker, MK, Bartz, TM, Bennett, DA, Bis, JC, Bordes, C, Borte, S, Cain, A, Ridker, PM, Cho, K, Chen, Z, Cruchaga, C, Cole, JW, de Jager, PL, de Cid, R, Endres, M, Ferreira, LE, Geerlings, MI, Gasca, NC, Gudnason, V, Hata, J, He, J, Heath, AK, Ho, Y-L, Havulinna, AS, Hopewell, JC, Hyacinth, HI, Inouye, M, Jacob, MA, Jeon, CE, Jern, C, Kamouchi, M, Keene, KL, Kitazono, T, Kittner, SJ, Konuma, T, Kumar, A, Lacaze, P, Launer, LJ, Lee, K-J, Lepik, K, Li, J, Li, L, Manichaikul, A, Markus, HS, Marston, NA, Meitinger, T, Mitchell, BD, Montellano, FA, Morisaki, T, Mosley, TH, Nalls, MA, Nordestgaard, BG, O'Donnell, MJ, Okada, Y, Onland-Moret, NC, Ovbiagele, B, Peters, A, Psaty, BM, Rich, SS, Rosand, J, Sabatine, MS, Sacco, RL, Saleheen, D, Sandset, EC, Salomaa, V, Sargurupremraj, M, Sasaki, M, Satizabal, CL, Schmidt, CO, Shimizu, A, Smith, NL, Sloane, KL, Sutoh, Y, Sun, YV, Tanno, K, Tiedt, S, Tatlisumak, T, Torres-Aguila, NP, Tiwari, HK, Tregouet, D-A, Trompet, S, Tuladhar, AM, Tybjaerg-Hansen, A, van Vugt, M, Vibo, R, Verma, SS, Wiggins, KL, Wennberg, P, Woo, D, Wilson, PWF, Xu, H, Yang, Q, Yoon, K, Millwood, IY, Gieger, C, Ninomiya, T, Grabe, HJ, Jukema, JW, Rissanen, IL, Strbian, D, Kim, YJ, Chen, P-H, Mayerhofer, E, Howson, JMM, Irvin, MR, Adams, H, Wassertheil-Smoller, S, Christensen, K, Ikram, MA, Rundek, T, Worrall, BB, Lathrop, GM, Riaz, M, Simonsick, EM, Korv, J, Franca, PHC, Zand, R, Prasad, K, Frikke-Schmidt, R, de Leeuw, F-E, Liman, T, Haeusler, KG, Ruigrok, YM, Heuschmann, PU, Longstreth, WT, Jung, KJ, Bastarache, L, Pare, G, Damrauer, SM, Chasman, DI, Rotter, JI, Anderson, CD, Zwart, J-A, Niiranen, TJ, Fornage, M, Liaw, Y-P, Seshadri, S, Fernandez-Cadenas, I, Walters, RG, Ruff, CT, Owolabi, MO, Huffman, JE, Milani, L, Kamatani, Y, Dichgans, M, Debette, S, Lee, J-M, Cheng, Y-C, Meschia, JF, Chen, WM, Sale, MM, Zonderman, AB, Evans, MK, Wilson, JG, Correa, A, Traylor, M, Lewis, CM, Reiner, A, Haessler, J, Langefeld, CD, Gottesman, RF, Yaffe, K, Liu, YM, Kooperberg, C, Lange, LA, Furie, KL, Arnett, DK, Benavente, OR, Grewal, RP, Peddareddygari, LR, Hveem, K, Lindstrom, S, Wang, L, Smith, EN, Gordon, W, Vlieg, AVH, de Andrade, M, Brody, JA, Pattee, JW, Brumpton, BM, Suchon, P, Chen, M-H, Frazer, KA, Turman, C, Germain, M, MacDonald, J, Braekkan, SK, Armasu, SM, Pankratz, N, Jackson, RD, Nielsen, JB, Giulianin, F, Puurunen, MK, Ibrahim, M, Heckbert, SR, Bammler, TK, McCauley, BM, Taylor, KD, Pankow, JS, Reiner, AP, Gabrielsen, ME, Deleuze, J-F, O'Donnell, CJ, Kim, J, McKnight, B, Kraft, P, Hansen, J-B, Rosendaal, FR, Heit, JA, Tang, W, Morange, P-E, Johnson, AD, Kabrhel, C, van Dijk, EJ, Koudstaal, PJ, Luijckx, G-J, Nederkoorn, PJ, van Oostenbrugge, RJ, Visser, MC, Wermer, MJH, Kappelle, LJ, Esko, T, Metspalu, A, Magi, R, Nelis, M, Levi, CR, Maguire, J, Jimenez-Conde, J, Sharma, P, Sudlow, CLM, Rannikmae, K, Schmidt, R, Slowik, A, Pera, J, Thijs, VNS, Lindgren, AG, Ilinca, A, Melander, O, Engstrom, G, Rexrode, KM, Rothwell, PM, Stanne, TM, Johnson, JA, Danesh, J, Butterworth, AS, Heitsch, L, Boncoraglio, GB, Kubo, M, Pezzini, A, Rolfs, A, Giese, A-K, Weir, D, Ross, OA, Lemmons, R, Soderholm, M, Cushman, M, Jood, K, McDonough, CW, Bell, S, Linkohr, B, Lee, T-H, Putaala, J, Lopez, OL, Carty, CL, Jian, X, Schminke, U, Cullell, N, Delgado, P, Ibanez, L, Krupinski, J, Lioutas, V, Matsuda, K, Montaner, J, Muino, E, Roquer, J, Sarnowski, C, Sattar, N, Sibolt, G, Teumer, A, Rutten-Jacobs, L, Kanai, M, Gretarsdottir, S, Rost, NS, Yusuf, S, Almgren, P, Ay, H, Bevan, S, Brown, RD, Carrera, C, Buring, JE, Chen, W-M, Cotlarciuc, I, de Bakker, PIW, DeStefano, AL, den Hoed, M, Duan, Q, Engelter, ST, Falcone, GJ, Gustafsson, S, Hassan, A, Holliday, EG, Howard, G, Hsu, F-C, Ingelsson, E, Harris, TB, Kissela, BM, Kleindorfer, DO, Langenberg, C, Leys, D, Lin, W-Y, Lorentzen, E, Magnusson, PK, McArdle, PF, Pulit, SL, Rice, K, Sakaue, S, Sapkota, BR, Tanislav, C, Thorleifsson, G, Thorsteinsdottir, U, Tzourio, C, van Duijn, CM, Walters, M, Wareham, NJ, Amin, N, Aparicio, HJ, Attia, J, Beiser, AS, Berr, C, Bustamante, M, Caso, V, Choi, SH, Chowhan, A, Dartigues, J-F, Delavaran, H, Dorr, M, Ford, I, Gurpreet, WS, Hamsten, A, Hozawa, A, Ingelsson, M, Iwasaki, M, Kaffashian, S, Kalra, L, Kjartansson, O, Kloss, M, Labovitz, DL, Laurie, CC, Lind, L, Lindgren, CM, Makoto, H, Minegishi, N, Morris, AP, Mueller-Nurasyid, M, Norrving, B, Ogishima, S, Parati, EA, Pedersen, NL, Perola, M, Jousilahti, P, Pileggi, S, Rabionet, R, Riba-Llena, I, Ribases, M, Romero, JR, Rudd, AG, Sarin, A-P, Sarju, R, Satoh, M, Sawada, N, Sigurdsson, A, Smith, A, Stine, OC, Stott, DJ, Strauch, K, Takai, T, Tanaka, H, Touze, E, Tsugane, S, Uitterlinden, AG, Valdimarsson, EM, van der Lee, SJ, Wakai, K, Williams, SR, Wolfe, CDA, Wong, Q, Yamaji, T, Sanghera, DK, Stefansson, K, Martinez-Majander, N, Sobue, K, Soriano-Tarraga, C, Volzke, H, Akpa, O, Sarfo, FS, Akpalu, A, Obiako, R, Wahab, K, Osaigbovo, G, Owolabi, L, Komolafe, M, Jenkins, C, Arulogun, O, Ogbole, G, Adeoye, AM, Akinyemi, J, Agunloye, A, Fakunle, AG, Uvere, E, Olalere, A, Adebajo, OJ, Chen, J, Clarke, R, Collins, R, Guo, Y, Wang, C, Lv, J, Peto, R, Chen, Y, Fairhurst-Hunter, Z, Hill, M, Pozarickij, A, Schmidt, D, Stevens, B, Turnbull, I, Yu, C, Nagai, A, Murakami, Y, Shiroma, EJ, Sigurdsson, S, Ghanbari, M, Boerwinkle, E, Fongang, B, Wang, R, Ikram, MK, Volker, U, de Laat, KF, van Norden, AGW, de Kort, PL, Vermeer, SE, Brouwers, PJAM, Gons, RAR, den Heijer, T, van Dijk, GW, van Rooij, FGW, Aamodt, AH, Skogholt, AH, Willer, CJ, Heuch, I, Hagen, K, Fritsche, LG, Pedersen, LM, Ellekjaer, H, Zhou, W, Martinsen, AE, Kristoffersen, ES, Thomas, LF, Kleinschnitz, C, Frantz, S, Ungethum, K, Gallego-Fabrega, C, Lledos, M, Llucia-Carol, L, Sobrino, T, Campos, F, Castillo, J, Freijo, M, Arenillas, JF, Obach, V, Alvarez-Sabin, J, Molina, CA, Ribo, M, Munoz-Narbona, L, Lopez-Cancio, E, Millan, M, Diaz-Navarro, R, Vives-Bauza, C, Serrano-Heras, G, Segura, T, Dhar, R, Delgado-Mederos, R, Prats-Sanchez, L, Camps-Renom, P, Blay, N, Sumoy, L, Marti-Fabregas, J, Schnohr, P, Jensen, GB, Benn, M, Afzal, S, Kamstrup, PR, van Setten, J, van der Laan, SW, Vonk, JMJ, Kim, B-J, Curtze, S, Tiainen, M, Kinnunen, J, Menon, V, Sung, YJ, Saillour-Glenisson, F, Gravel, S, Mishra, A, Malik, R, Hachiya, T, Jurgenson, T, Namba, S, Posner, DC, Kamanu, FK, Koido, M, Le Grand, Q, Shi, M, He, Y, Georgakis, MK, Caro, I, Krebs, K, Liaw, Y-C, Vaura, FC, Lin, K, Winsvold, BS, Srinivasasainagendra, V, Parodi, L, Bae, H-J, Chauhan, G, Chong, MR, Tomppo, L, Akinyemi, R, Roshchupkin, GV, Habib, N, Jee, YH, Thomassen, JQ, Abedi, V, Carcel-Marquez, J, Nygaard, M, Leonard, HL, Yang, C, Yonova-Doing, E, Knol, MJ, Lewis, AJ, Judy, RL, Ago, T, Amouyel, P, Armstrong, ND, Bakker, MK, Bartz, TM, Bennett, DA, Bis, JC, Bordes, C, Borte, S, Cain, A, Ridker, PM, Cho, K, Chen, Z, Cruchaga, C, Cole, JW, de Jager, PL, de Cid, R, Endres, M, Ferreira, LE, Geerlings, MI, Gasca, NC, Gudnason, V, Hata, J, He, J, Heath, AK, Ho, Y-L, Havulinna, AS, Hopewell, JC, Hyacinth, HI, Inouye, M, Jacob, MA, Jeon, CE, Jern, C, Kamouchi, M, Keene, KL, Kitazono, T, Kittner, SJ, Konuma, T, Kumar, A, Lacaze, P, Launer, LJ, Lee, K-J, Lepik, K, Li, J, Li, L, Manichaikul, A, Markus, HS, Marston, NA, Meitinger, T, Mitchell, BD, Montellano, FA, Morisaki, T, Mosley, TH, Nalls, MA, Nordestgaard, BG, O'Donnell, MJ, Okada, Y, Onland-Moret, NC, Ovbiagele, B, Peters, A, Psaty, BM, Rich, SS, Rosand, J, Sabatine, MS, Sacco, RL, Saleheen, D, Sandset, EC, Salomaa, V, Sargurupremraj, M, Sasaki, M, Satizabal, CL, Schmidt, CO, Shimizu, A, Smith, NL, Sloane, KL, Sutoh, Y, Sun, YV, Tanno, K, Tiedt, S, Tatlisumak, T, Torres-Aguila, NP, Tiwari, HK, Tregouet, D-A, Trompet, S, Tuladhar, AM, Tybjaerg-Hansen, A, van Vugt, M, Vibo, R, Verma, SS, Wiggins, KL, Wennberg, P, Woo, D, Wilson, PWF, Xu, H, Yang, Q, Yoon, K, Millwood, IY, Gieger, C, Ninomiya, T, Grabe, HJ, Jukema, JW, Rissanen, IL, Strbian, D, Kim, YJ, Chen, P-H, Mayerhofer, E, Howson, JMM, Irvin, MR, Adams, H, Wassertheil-Smoller, S, Christensen, K, Ikram, MA, Rundek, T, Worrall, BB, Lathrop, GM, Riaz, M, Simonsick, EM, Korv, J, Franca, PHC, Zand, R, Prasad, K, Frikke-Schmidt, R, de Leeuw, F-E, Liman, T, Haeusler, KG, Ruigrok, YM, Heuschmann, PU, Longstreth, WT, Jung, KJ, Bastarache, L, Pare, G, Damrauer, SM, Chasman, DI, Rotter, JI, Anderson, CD, Zwart, J-A, Niiranen, TJ, Fornage, M, Liaw, Y-P, Seshadri, S, Fernandez-Cadenas, I, Walters, RG, Ruff, CT, Owolabi, MO, Huffman, JE, Milani, L, Kamatani, Y, Dichgans, M, Debette, S, Lee, J-M, Cheng, Y-C, Meschia, JF, Chen, WM, Sale, MM, Zonderman, AB, Evans, MK, Wilson, JG, Correa, A, Traylor, M, Lewis, CM, Reiner, A, Haessler, J, Langefeld, CD, Gottesman, RF, Yaffe, K, Liu, YM, Kooperberg, C, Lange, LA, Furie, KL, Arnett, DK, Benavente, OR, Grewal, RP, Peddareddygari, LR, Hveem, K, Lindstrom, S, Wang, L, Smith, EN, Gordon, W, Vlieg, AVH, de Andrade, M, Brody, JA, Pattee, JW, Brumpton, BM, Suchon, P, Chen, M-H, Frazer, KA, Turman, C, Germain, M, MacDonald, J, Braekkan, SK, Armasu, SM, Pankratz, N, Jackson, RD, Nielsen, JB, Giulianin, F, Puurunen, MK, Ibrahim, M, Heckbert, SR, Bammler, TK, McCauley, BM, Taylor, KD, Pankow, JS, Reiner, AP, Gabrielsen, ME, Deleuze, J-F, O'Donnell, CJ, Kim, J, McKnight, B, Kraft, P, Hansen, J-B, Rosendaal, FR, Heit, JA, Tang, W, Morange, P-E, Johnson, AD, Kabrhel, C, van Dijk, EJ, Koudstaal, PJ, Luijckx, G-J, Nederkoorn, PJ, van Oostenbrugge, RJ, Visser, MC, Wermer, MJH, Kappelle, LJ, Esko, T, Metspalu, A, Magi, R, Nelis, M, Levi, CR, Maguire, J, Jimenez-Conde, J, Sharma, P, Sudlow, CLM, Rannikmae, K, Schmidt, R, Slowik, A, Pera, J, Thijs, VNS, Lindgren, AG, Ilinca, A, Melander, O, Engstrom, G, Rexrode, KM, Rothwell, PM, Stanne, TM, Johnson, JA, Danesh, J, Butterworth, AS, Heitsch, L, Boncoraglio, GB, Kubo, M, Pezzini, A, Rolfs, A, Giese, A-K, Weir, D, Ross, OA, Lemmons, R, Soderholm, M, Cushman, M, Jood, K, McDonough, CW, Bell, S, Linkohr, B, Lee, T-H, Putaala, J, Lopez, OL, Carty, CL, Jian, X, Schminke, U, Cullell, N, Delgado, P, Ibanez, L, Krupinski, J, Lioutas, V, Matsuda, K, Montaner, J, Muino, E, Roquer, J, Sarnowski, C, Sattar, N, Sibolt, G, Teumer, A, Rutten-Jacobs, L, Kanai, M, Gretarsdottir, S, Rost, NS, Yusuf, S, Almgren, P, Ay, H, Bevan, S, Brown, RD, Carrera, C, Buring, JE, Chen, W-M, Cotlarciuc, I, de Bakker, PIW, DeStefano, AL, den Hoed, M, Duan, Q, Engelter, ST, Falcone, GJ, Gustafsson, S, Hassan, A, Holliday, EG, Howard, G, Hsu, F-C, Ingelsson, E, Harris, TB, Kissela, BM, Kleindorfer, DO, Langenberg, C, Leys, D, Lin, W-Y, Lorentzen, E, Magnusson, PK, McArdle, PF, Pulit, SL, Rice, K, Sakaue, S, Sapkota, BR, Tanislav, C, Thorleifsson, G, Thorsteinsdottir, U, Tzourio, C, van Duijn, CM, Walters, M, Wareham, NJ, Amin, N, Aparicio, HJ, Attia, J, Beiser, AS, Berr, C, Bustamante, M, Caso, V, Choi, SH, Chowhan, A, Dartigues, J-F, Delavaran, H, Dorr, M, Ford, I, Gurpreet, WS, Hamsten, A, Hozawa, A, Ingelsson, M, Iwasaki, M, Kaffashian, S, Kalra, L, Kjartansson, O, Kloss, M, Labovitz, DL, Laurie, CC, Lind, L, Lindgren, CM, Makoto, H, Minegishi, N, Morris, AP, Mueller-Nurasyid, M, Norrving, B, Ogishima, S, Parati, EA, Pedersen, NL, Perola, M, Jousilahti, P, Pileggi, S, Rabionet, R, Riba-Llena, I, Ribases, M, Romero, JR, Rudd, AG, Sarin, A-P, Sarju, R, Satoh, M, Sawada, N, Sigurdsson, A, Smith, A, Stine, OC, Stott, DJ, Strauch, K, Takai, T, Tanaka, H, Touze, E, Tsugane, S, Uitterlinden, AG, Valdimarsson, EM, van der Lee, SJ, Wakai, K, Williams, SR, Wolfe, CDA, Wong, Q, Yamaji, T, Sanghera, DK, Stefansson, K, Martinez-Majander, N, Sobue, K, Soriano-Tarraga, C, Volzke, H, Akpa, O, Sarfo, FS, Akpalu, A, Obiako, R, Wahab, K, Osaigbovo, G, Owolabi, L, Komolafe, M, Jenkins, C, Arulogun, O, Ogbole, G, Adeoye, AM, Akinyemi, J, Agunloye, A, Fakunle, AG, Uvere, E, Olalere, A, Adebajo, OJ, Chen, J, Clarke, R, Collins, R, Guo, Y, Wang, C, Lv, J, Peto, R, Chen, Y, Fairhurst-Hunter, Z, Hill, M, Pozarickij, A, Schmidt, D, Stevens, B, Turnbull, I, Yu, C, Nagai, A, Murakami, Y, Shiroma, EJ, Sigurdsson, S, Ghanbari, M, Boerwinkle, E, Fongang, B, Wang, R, Ikram, MK, Volker, U, de Laat, KF, van Norden, AGW, de Kort, PL, Vermeer, SE, Brouwers, PJAM, Gons, RAR, den Heijer, T, van Dijk, GW, van Rooij, FGW, Aamodt, AH, Skogholt, AH, Willer, CJ, Heuch, I, Hagen, K, Fritsche, LG, Pedersen, LM, Ellekjaer, H, Zhou, W, Martinsen, AE, Kristoffersen, ES, Thomas, LF, Kleinschnitz, C, Frantz, S, Ungethum, K, Gallego-Fabrega, C, Lledos, M, Llucia-Carol, L, Sobrino, T, Campos, F, Castillo, J, Freijo, M, Arenillas, JF, Obach, V, Alvarez-Sabin, J, Molina, CA, Ribo, M, Munoz-Narbona, L, Lopez-Cancio, E, Millan, M, Diaz-Navarro, R, Vives-Bauza, C, Serrano-Heras, G, Segura, T, Dhar, R, Delgado-Mederos, R, Prats-Sanchez, L, Camps-Renom, P, Blay, N, Sumoy, L, Marti-Fabregas, J, Schnohr, P, Jensen, GB, Benn, M, Afzal, S, Kamstrup, PR, van Setten, J, van der Laan, SW, Vonk, JMJ, Kim, B-J, Curtze, S, Tiainen, M, Kinnunen, J, Menon, V, Sung, YJ, Saillour-Glenisson, F, and Gravel, S

Abstract

Previous genome-wide association studies (GWASs) of stroke - the second leading cause of death worldwide - were conducted predominantly in populations of European ancestry1,2. Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. On the basis of internal cross-ancestry validation and an independent follow-up in 89,084 additional cases of stroke (30% non-European) and 1,013,843 control individuals, 87% of the primary stroke risk loci and 60% of the secondary stroke risk loci were replicated (P < 0.05). Effect sizes were highly correlated across ancestries. Cross-ancestry fine-mapping, in silico mutagenesis analysis3, and transcriptome-wide and proteome-wide association analyses revealed putative causal genes (such as SH3PXD2A and FURIN) and variants (such as at GRK5 and NOS3). Using a three-pronged approach4, we provide genetic evidence for putative drug effects, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as possible targets, with drugs already under investigation for stroke for F11 and PROC. A polygenic score integrating cross-ancestry and ancestry-specific stroke GWASs with vascular-risk factor GWASs (integrative polygenic scores) strongly predicted ischaemic stroke in populations of European, East Asian and African ancestry5. Stroke genetic risk scores were predictive of ischaemic stroke independent of clinical risk factors in 52,600 clinical-trial participants with cardiometabolic disease. Our results provide insights to inform biology, reveal potential drug targets and derive genetic risk prediction tools across ancestries.

Published
2022

49. Serious maternal complications after early preterm delivery (24-33 weeks’ gestation)

Author

Reddy, Uma M., Rice, Madeline Murguia, Grobman, William A., Bailit, Jennifer L., Wapner, Ronald J., Varner, Michael W., Thorp, John M., Jr., Leveno, Kenneth J., Caritis, Steve N., Prasad, Mona, Tita, Alan T.N., Saade, George R., Sorokin, Yoram, Rouse, Dwight J., Blackwell, Sean C., Tolosa, Jorge E., Spong, C., Tolivaisa, S., Talucci, M., Zylfijaj, M., Reid, Z., Leed, R., Benson, J., Forester, S., Kitto, C., Davis, S., Falk, M., Perez, C., Hill, K., Sowles, A., Postma, J., Alexander, S., Andersen, G., Scott, V., Morby, V., Jolley, K., Miller, J., Berg, B., Dorman, K., Mitchell, J., Kaluta, E., Clark, K., Spicer, K., Timlin, S., Wilson, K., Moseley, L., Santillan, M., Price, J., Buentipo, K., Bludau, V., Thomas, T., Fay, L., Melton, C., Kingsbery, J., Benezue, R., Simhan, H., Bickus, M., Fischer, D., Kamon, T., DeAngelis, D., Mercer, B., Milluzzi, C., Dalton, W., Dotson, T., McDonald, P., Brezine, C., McGrail, A., Latimer, C., Guzzo, L., Johnson, F., Gerwig, L., Fyffe, S., Loux, D., Frantz, S., Cline, D., Wylie, S., Iams, J., Wallace, M., Northen, A., Grant, J., Colquitt, C., Rouse, D., Andrews, W., Mallett, G., Ramos-Brinson, M., Roy, A., Stein, L., Campbell, P., Collins, C., Jackson, N., Dinsmoor, M., Senka, J., Paychek, K., Peaceman, A., Moss, J., Salazar, A., Acosta, A., Hankins, G., Hauff, N., Palmer, L., Lockhart, P., Driscoll, D., Wynn, L., Sudz, C., Dengate, D., Girard, C., Field, S., Breault, P., Smith, F., Annunziata, N., Allard, D., Silva, J., Gamage, M., Hunt, J., Tillinghast, J., Corcoran, N., Jimenez, M., Ortiz, F., Givens, P., Rech, B., Moran, C., Hutchinson, M., Spears, Z., Carreno, C., Heaps, B., Zamora, G., Seguin, J., Rincon, M., Snyder, J., Farrar, C., Lairson, E., Bonino, C., Smith, W., Beach, K., Van Dyke, S., Butcher, S., Thom, E., Zhao, Y., McGee, P., Momirova, V., Palugod, R., Reamer, B., Larsen, M., Spangler, T., Bhandaru, V., and VanDorsten, J. P.

Published
2015
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50. Does the presence of a condition-specific obstetric protocol lead to detectable improvements in pregnancy outcomes?

Author

Bailit, Jennifer L., Grobman, William A., McGee, Paula, Reddy, Uma M., Wapner, Ronald J., Varner, Michael W., Thorp, John M., Leveno, Kenneth J., Iams, Jay D., Tita, Alan T.N., Saade, George, Sorokin, Yoram, Rouse, Dwight J., Blackwell, Sean C., Mercer, B., Milluzzi, C., Dalton, W., Dotson, T., McDonald, P., Brezine, C., McGrail, A., Mallett, G., Ramos-Brinson, M., Roy, A., Stein, L., Campbell, P., Collins, C., Jackson, N., Dinsmoor, M., Senka, J., Paychek, K., Peaceman, A., Talucci, M., Zylfijaj, M., Reid, Z., Leed, R., Benson, J., Forester, S., Kitto, C., Davis, S., Falk, M., Perez, C., Hill, K., Sowles, A., Postma, J., Alexander, S., Andersen, G., Scott, V., Morby, V., Jolley, K., Miller, J., Berg, B., Dorman, K., Mitchell, J., Kaluta, E., Clark, K., Spicer, K., Timlin, S., Wilson, K., Moseley, L., Santillan, M., Price, J., Buentipo, K., Bludau, V., Thomas, T., Fay, L., Melton, C., Kingsbery, J., Benezue, R., Caritis, S., Simhan, H., Bickus, M., Fischer, D., Kamon, T., DeAngelis, D., Shubert, P., Latimer, C., Guzzo, L., Johnson, F., Gerwig, L., Fyffe, S., Loux, D., Frantz, S., Cline, D., Wylie, S., Iams, J., Wallace, M., Northen, A., Grant, J., Colquitt, C., Moss, J., Salazar, A., Acosta, A., Hankins, G., Hauff, N., Palmer, L., Lockhart, P., Driscoll, D., Wynn, L., Sudz, C., Dengate, D., Girard, C., Field, S., Breault, P., Smith, F., Annunziata, N., Allard, D., Silva, J., Gamage, M., Hunt, J., Tillinghast, J., Corcoran, N., Jimenez, M., Ortiz, F., Givens, P., Rech, B., Moran, C., Hutchinson, M., Spears, Z., Carreno, C., Heaps, B., Zamora, G., Tolosa, J., Seguin, J., Rincon, M., Snyder, J., Farrar, C., Lairson, E., Bonino, C., Smith, W., Beach, K., Van Dyke, S., Butcher, S., Thom, E., Rice, M., Zhao, Y., McGee, P., Momirova, V., Palugod, R., Reamer, B., Larsen, M., Williams, T., Spong, C., Tolivaisa, S., and Van Dorsten, J. P.

Published
2015
Full Text
View/download PDF

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