24 results on '"Franssen, Marloes"'
Search Results
2. Sensorimotor functioning changes in response to global exercise versus handwriting upper limb exercise training in Parkinson's disease, results from a phase II randomised controlled trial.
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Moraes, Íbis Ariana Peña de, Collett, Johnny, Silva, Talita Dias da, Franssen, Marloes, Mitta, Surabhi, Zalewski, Paweł, Meaney, Andy, Wade, Derick, Izadi, Hooshang, Winward, Charlotte, Monteiro, Carlos Bandeira de Mello, and Dawes, Helen
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EXERCISE therapy ,PARKINSON'S disease ,RANDOMIZED controlled trials ,HANDWRITING ,EVERYDAY life ,REACTION time - Abstract
Introduction: People with Parkinson's disease (PwPD) present motor alterations which can impact daily life tasks that require speed and/or accuracy of movement. Objective: A sub analysis of NCT01439022, aiming to estimate the extent to which two different exercise training protocols (global and handwriting upper limb exercise training) impact reaction time, travel speed, and accuracy in PwPD. Methods: Seventy PwPD, right-side dominant were randomised 1:1 into two six-month training protocol groups; 35 PwPD performed global exercise training and 35 performed specific training (handwriting upper limb exercise movements). Assessments of speed-accuracy and trade-off were carried out at baseline, after 3 and 6 months of training, and at a 12-month follow-up. The current study used data from a previous publication of a randomised controlled trial that included a 6-month self-managed community exercise programme for PwPD. For the present study we included only the participants who completed the Fitts' task during the baseline assessment. Results: In the upper limb assessments, no main effects were found for the number of touches, but the exercise group showed a marginal increase over time on the left side. Error averages on the left side decreased significantly for the exercise group from baseline to 6 and 12 months. The exercise group also presented a lower Error CoV and the Reaction Time CoV increased on the right side. Significant findings for Fitts r on the left side indicated lower values for the exercise group, with improvements continuing at 12 months. Conclusion: We report the potential of global exercise interventions to facilitate improvements in reaction time and travel speed, as well as other motor control metrics, with lasting effects at 12 months, particularly on the non-dominant side. [ABSTRACT FROM AUTHOR]
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- 2024
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3. d-Mannose for Prevention of Recurrent Urinary Tract Infection Among Women: A Randomized Clinical Trial.
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Hayward, Gail, Mort, Sam, Hay, Alastair D., Moore, Michael, Thomas, Nicholas P. B., Cook, Johanna, Robinson, Jared, Williams, Nicola, Maeder, Nicola, Edeson, Rebecca, Franssen, Marloes, Grabey, Jenna, Glogowska, Margaret, Yang, Yaling, Allen, Julie, and Butler, Christopher C.
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- 2024
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4. Fatigue in people with Parkinson's disease : the effects of exercise
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Franssen, Marloes
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616.8 - Abstract
This thesis comprises a systematic review and an intervention study. The systematic review included a meta-analysis and investigated treatment methods for fatigue. Fourteen studies (n=1890) were included in the systematic review and results from the meta-analyses (mean difference -0.25; CI -0.67:0.16; z-score 1.20 and mean difference -0.36; CI -0.78:0.06; z-score 1.67) concluded that currently there are no effective methods for the treatment of fatigue in people with Parkinson’s disease. The intervention study (n=105; intervention group: n=54; control group: n=51) comprised three parts. In the first part different measures of fatigue were explored in relation to activity levels and exercise tolerance. The second part investigated the adherence to the community based six-month exercise programme. The final part of the main study explored the effects of the exercise programme in a single blinded randomised controlled trial. In the first part of the main study significant negative correlations were found between self-reported fatigue and respiratory exchange rate (r=-0.309; p=0.002); Rate of Perceived Exertion breath (r=-0.282; p=0.024); Rate of Perceived Exertion of the legs (r=-0.261; p=0.033) and GENEActiv light activity (r=-0.209; p=0.049). The correlation between self-reported fatigue and the respiratory exchange rate implies that self-reported fatigue may decrease if exercise tolerance is improved by for example an exercise programme. The second part of the main study demonstrated an adherence of 24 out of 54 in participants that were randomly assigned to the exercise programme, with no intervention-related adverse events, showing that the proposed programme was feasible for people with Parkinson’s disease. The final part of the study, exploring the effects of the exercise programme in all patients, showed a small reduction in disease severity (Unified Parkinson’s disease Rating Scale part III, Cohen’s d: 0.25; 95% confidence interval: 0.02-0.49) in the treatment group compared to the control group. Scores on the self-reported fatigue decreased slightly in both groups subsequent to the exercise programme, but did not reach significance. This is the first study to explore the effects of a combined (aerobic and anaerobic) exercise community based longer term (six months) exercise programme on fatigue in people with Parkinson’s disease. Results show that both arms of the interventions were adhered to reasonably well and small effects were found showing exercise improved disease severity in people with Parkinson’s disease; no effects were found in relation to fatigue.
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- 2015
5. Intervention planning and modification of the BUMP intervention: a digital intervention for the early detection of raised blood pressure in pregnancy
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Band, Rebecca, Hinton, Lisa, Tucker, Katherine L., Chappell, Lucy C., Crawford, Carole, Franssen, Marloes, Greenfield, Sheila, Hodgkinson, James, McCourt, Christine, McManus, Richard J., Sandall, Jane, Santos, Mauro Dala, Velardo, Carmelo, and Yardley, Lucy
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- 2019
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6. Defining the relationship between arm and leg blood pressure readings: a systematic review and meta-analysis
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Sheppard, James P., Albasri, Ali, Franssen, Marloes, Fletcher, Ben, Pealing, Louise, Roberts, Nia, Obeid, Amira, Pucci, Mark, McManus, Richard J., and Martin, Una
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- 2018
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7. Cost-Effectiveness of Telemonitoring and Self-Monitoring of Blood Pressure for Antihypertensive Titration in Primary Care (TASMINH4)
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Monahan, Mark, Jowett, Sue, Nickless, Alecia, Franssen, Marloes, Grant, Sabrina, Greenfield, Sheila, Hobbs, F. D. Richard, Hodgkinson, James, Mant, Jonathan, and McManus, Richard J.
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- 2019
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8. Defining the relationship between arm and leg blood pressure readings: a systematic review and meta-analysis
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Sheppard, James P., Albasri, Ali, Franssen, Marloes, Fletcher, Ben, Pealing, Louise, Roberts, Nia, Obeid, Amira, Pucci, Mark, McManus, Richard J., and Martin, Una
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- 2019
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9. A long-term self-managed handwriting intervention for people with Parkinson’s disease: results from the control group of a phase II randomized controlled trial
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Collett, Johnny, Franssen, Marloes, Winward, Charlotte, Izadi, Hooshang, Meaney, Andy, Mahmoud, Wala, Bogdanovic, Marko, Tims, Martin, Wade, Derick, and Dawes, Helen
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- 2017
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10. Phase II randomised controlled trial of a 6-month self-managed community exercise programme for people with Parkinsonʼs disease
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Collett, Johnny, Franssen, Marloes, Meaney, Andy, Wade, Derick, Izadi, Hooshang, Tims, Martin, Winward, Charlotte, Bogdanovic, Marko, Farmer, Andrew, and Dawes, Helen
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- 2017
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11. Effect of Self-monitoring of Blood Pressure on Blood Pressure Control in Pregnant Individuals With Chronic or Gestational Hypertension
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Chappell, Lucy C., Tucker, Katherine L., Galal, Ushma, Yu, Ly-mee, Campbell, Helen, Rivero-arias, Oliver, Allen, Julie, Band, Rebecca, Chisholm, Alison, Crawford, Carole, Dougall, Greig, Engonidou, Lazarina, Franssen, Marloes, Green, Marcus, Greenfield, Sheila, Hinton, Lisa, Hodgkinson, James, Lavallee, Layla, Leeson, Paul, Mccourt, Christine, Mackillop, Lucy, Sandall, Jane, Santos, Mauro, Tarassenko, Lionel, Velardo, Carmelo, Wilson, Hannah, Yardley, Lucy, Mcmanus, Richard J., Cook, Johanna, Coates, Maria, Gabriel, Thomas, Brann, Stephanie, De Henau, Joris, Kelly, Sadie, Watt, Dave, Judge, David, Castello, Luis, Wishlade, Tabitha, Price, Helen, Fotaki, Eleni, Vowles, Zoe, Lewin, Alice, Tarft, Hayley, Wade, Julie, Symington, Declan, Hunt, Jessamine, Slaney, Maria, Mungeam, Charlotte, Khan, Rehan, Thomas, Amy, Newman, Tabitha, Gouldbourne, Melanie, Keen, Alexandra, Rossi, Alice, Maseko, Zandile, Churchill, David, Devison, Laura, Brooks, Kayleigh, Icke, Julia, Bose, Patrick, Lee, Fidelma, Scanlon, Suzanne, Girling, Joanna, Johnson, Mark, Singh, Natasha, Martella, Carmela, Adamson, Christine, Sogo Buaki, Maria, Beadle, Nikki, Hickey, Harriet, Iriondo-coysh, Amanda, Chilvers, Joanna, Duncan, Daisy, Bourke, Miriam, Myers, Jenny, Barry, Natalie, Glossop, Heather, Farrant, Kimberley, Waters, Clare, Thamban, Sujatha, Jones, Prudence, Felippe, Sophia, Kametas, Nick, Kay, Polly, Clark, Katherine, Jarman, Rebecca, Snowball, Olivia, Martin, Hayley, Osakwe, Osaeloke, Tilley, Bernadette, Barker, Any, Gonzalez, Raquel, Khalil, Asma, Robinson, Sophie, Canclini, Lisa, Unwin, Rebecca, Morris, Katie, Mellers, Dianne, Adams, Phern, Brittain, Lesley, Dann, Sohpie, O'hara, Chloe, Whitehouse, Diane, Ajay, Bini, Upson, Geraldine, O'donnell, Hannah, Zammit-mangion, Maria, Tebbutt, Julie, Frankland, Lisa, Thornton, Danielle, Sexton, Kristina, Crowe, Rebecca, Bowers, Amy, Winterbottom, Joanne, Yardley, L, and investigators, BUMP2
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Adult ,Blood Pressure ,Hypertension, Pregnancy-Induced ,General Medicine ,Blood Pressure Monitoring, Ambulatory ,Telemedicine ,Self-Testing ,Pre-Eclampsia ,Pregnancy ,General & Internal Medicine ,Chronic Disease ,Hypertension ,Humans ,Female ,11 Medical and Health Sciences ,Antihypertensive Agents ,Original Investigation - Abstract
Importance Inadequate management of elevated blood pressure is a significant contributing factor to maternal deaths. The role of blood pressure self-monitoring in pregnancy in improving clinical outcomes for the pregnant individual and infant is unclear. Objective To evaluate the effect of blood pressure self-monitoring, compared with usual care alone, on blood pressure control and other related maternal and infant outcomes, in individuals with pregnancy hypertension. Design, Setting, and Participants Unblinded, randomized clinical trial that recruited between November 2018 and September 2019 in 15 hospital maternity units in England. Individuals with chronic hypertension (enrolled up to 37 weeks’ gestation) or with gestational hypertension (enrolled between 20 and 37 weeks’ gestation). Final follow-up was in May 2020. Interventions Participants were randomized to either blood pressure self-monitoring using a validated monitor and a secure telemonitoring system in addition to usual care (n = 430) or to usual care alone (n = 420). Usual care comprised blood pressure measured by health care professionals at regular antenatal clinics. Main Outcomes and Measures The primary maternal outcome was the difference in mean systolic blood pressure recorded by health care professionals between randomization and birth. Results Among 454 participants with chronic hypertension (mean age, 36 years; mean gestation at entry, 20 weeks) and 396 with gestational hypertension (mean age, 34 years; mean gestation at entry, 33 weeks) who were randomized, primary outcome data were available from 444 (97.8%) and 377 (95.2%), respectively. In the chronic hypertension cohort, there was no statistically significant difference in mean systolic blood pressure for the self-monitoring groups vs the usual care group (133.8 mm Hg vs 133.6 mm Hg, respectively; adjusted mean difference, 0.03 mm Hg [95% CI, −1.73 to 1.79]). In the gestational hypertension cohort, there was also no significant difference in mean systolic blood pressure (137.6 mm Hg compared with 137.2 mm Hg; adjusted mean difference, −0.03 mm Hg [95% CI, −2.29 to 2.24]). There were 8 serious adverse events in the self-monitoring group (4 in each cohort) and 3 in the usual care group (2 in the chronic hypertension cohort and 1 in the gestational hypertension cohort). Conclusions and Relevance Among pregnant individuals with chronic or gestational hypertension, blood pressure self-monitoring with telemonitoring, compared with usual care, did not lead to significantly improved clinic-based blood pressure control. Trial Registration ClinicalTrials.gov Identifier: NCT03334149
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- 2022
12. Interventions for fatigue in Parkinsonʼs disease: A systematic review and meta-analysis
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Franssen, Marloes, Winward, Charlotte, Collett, Johnny, Wade, Derick, and Dawes, Helen
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- 2014
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13. Effect of Self-monitoring of Blood Pressure on Diagnosis of Hypertension During Higher-Risk Pregnancy: The BUMP 1 Randomized Clinical Trial.
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Tucker, Katherine L., Mort, Sam, Yu, Ly-Mee, Campbell, Helen, Rivero-Arias, Oliver, Wilson, Hannah M., Allen, Julie, Band, Rebecca, Chisholm, Alison, Crawford, Carole, Dougall, Greig, Engonidou, Lazarina, Franssen, Marloes, Green, Marcus, Greenfield, Sheila, Hinton, Lisa, Hodgkinson, James, Lavallee, Layla, Leeson, Paul, and McCourt, Christine
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Key Points: Question: Does self-monitoring of blood pressure (BP) by pregnant individuals at higher risk for preeclampsia lead to earlier detection of pregnancy hypertension compared with usual antenatal care? Findings: In this randomized clinical trial that included 2441 pregnant individuals at increased risk for preeclampsia, self-monitoring of BP with telemonitoring compared with usual care resulted in a mean time to clinic-based detection of hypertension of 104 vs 106 days, a difference that was not statistically significant. Meaning: Among pregnant individuals at higher risk of preeclampsia, self-monitoring of BP with telemonitoring did not lead to earlier clinic-based detection of hypertension. Importance: Inadequate management of elevated blood pressure (BP) is a significant contributing factor to maternal deaths. Self-monitoring of BP in the general population has been shown to improve the diagnosis and management of hypertension; however, little is known about its use in pregnancy. Objective: To determine whether self-monitoring of BP in higher-risk pregnancies leads to earlier detection of pregnancy hypertension. Design, Setting, and Participants: Unblinded, randomized clinical trial that included 2441 pregnant individuals at higher risk of preeclampsia and recruited at a mean of 20 weeks' gestation from 15 hospital maternity units in England between November 2018 and October 2019. Final follow-up was completed in April 2020. Interventions: Participating individuals were randomized to either BP self-monitoring with telemonitoring (n = 1223) plus usual care or usual antenatal care alone (n = 1218) without access to telemonitored BP. Main Outcomes and Measures: The primary outcome was time to first recorded hypertension measured by a health care professional. Results: Among 2441 participants who were randomized (mean [SD] age, 33 [5.6] years; mean gestation, 20 [1.6] weeks), 2346 (96%) completed the trial. The time from randomization to clinic recording of hypertension was not significantly different between individuals in the self-monitoring group (mean [SD], 104.3 [32.6] days) vs in the usual care group (mean [SD], 106.2 [32.0] days) (mean difference, −1.6 days [95% CI, −8.1 to 4.9]; P =.64). Eighteen serious adverse events were reported during the trial with none judged as related to the intervention (12 [1%] in the self-monitoring group vs 6 [0.5%] in the usual care group). Conclusions and Relevance: Among pregnant individuals at higher risk of preeclampsia, blood pressure self-monitoring with telemonitoring, compared with usual care, did not lead to significantly earlier clinic-based detection of hypertension. Trial Registration: ClinicalTrials.gov Identifier: NCT03334149 This randomized clinical trial compares the efficacy of self-monitoring of blood pressure with telemonitoring vs usual antenatal care in detecting hypertension among pregnant individuals at higher risk of preeclampsia. [ABSTRACT FROM AUTHOR]
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- 2022
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14. D-MannosE to prevent Recurrent urinary tract InfecTions (MERIT): protocol for a randomised controlled trial
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Franssen, Marloes, primary, Cook, Johanna, additional, Robinson, Jared, additional, Williams, Nicola, additional, Glogowska, Margaret, additional, Yang, Yaling, additional, Allen, Julie, additional, Butler, Christopher C, additional, Thomas, Nick, additional, Hay, Alastair, additional, Moore, Michael, additional, and Hayward, Gail, additional
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- 2021
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15. The humeral shaft fracture trial: surgical versus non-surgical interventions for humeral shaft fractures in patients aged 18 years or older
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Franssen, Marloes, primary
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- 2020
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16. Blood pressure monitoring in high-risk pregnancy to improve the detection and monitoring of hypertension (the BUMP 1 and 2 trials): protocol for two linked randomised controlled trials
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Dougall, Greig, primary, Franssen, Marloes, additional, Tucker, Katherine Louise, additional, Yu, Ly-Mee, additional, Hinton, Lisa, additional, Rivero-Arias, Oliver, additional, Abel, Lucy, additional, Allen, Julie, additional, Band, Rebecca Jane, additional, Chisholm, Alison, additional, Crawford, Carole, additional, Green, Marcus, additional, Greenfield, Sheila, additional, Hodgkinson, James, additional, Leeson, Paul, additional, McCourt, Christine, additional, MacKillop, Lucy, additional, Nickless, Alecia, additional, Sandall, Jane, additional, Santos, Mauro, additional, Tarassenko, Lionel, additional, Velardo, Carmelo, additional, Wilson, Hannah, additional, Yardley, Lucy, additional, Chappell, Lucy, additional, and McManus, Richard J, additional
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- 2020
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17. Using mHealth for the management of hypertension in UK primary care: an embedded qualitative study of the TASMINH4 randomised controlled trial
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Grant, Sabrina, primary, Hodgkinson, James, additional, Schwartz, Claire, additional, Bradburn, Peter, additional, Franssen, Marloes, additional, Hobbs, FD Richard, additional, Jowett, Sue, additional, McManus, Richard J, additional, and Greenfield, Sheila, additional
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- 2019
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18. Telemonitoring and/or self-monitoring of blood pressure in hypertension (TASMINH4): protocol for a randomised controlled trial
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Franssen, Marloes, Farmer, Andrew, Grant, Sabrina, Greenfield, Sheila, Heneghan, Carl, Hobbs, Richard, Hodgkinson, James, Jowett, Susan, Mant, Jonathan, Martin, Una, Milner, Siobhan, Monahan, Mark, Ogburn, Emma, Perera-Salazar, Rafael, Schwartz, Claire, Yu, Ly-Mee, McManus, Richard J, Mant, Jonathan [0000-0002-9531-0268], and Apollo - University of Cambridge Repository
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Telemonitoring ,Primary Health Care ,Blood Pressure ,Blood Pressure Determination ,Blood Pressure Monitoring, Ambulatory ,Primary care ,Telemedicine ,United Kingdom ,Study Protocol ,Treatment Outcome ,Clinical Protocols ,Predictive Value of Tests ,Research Design ,Hypertension ,Humans ,Telemetry ,Self-monitoring ,Cardiology and Cardiovascular Medicine ,Antihypertensive Agents - Abstract
BACKGROUND: Self-monitoring of hypertension is associated with lower systolic blood pressure (SBP). However, evidence for the use of self-monitoring to titrate antihypertensive medication by physicians is equivocal. Furthermore, there is some evidence for the efficacy of telemonitoring in the management of hypertension but it is not clear what this adds over and above self-monitoring. This trial aims to evaluate whether GP led antihypertensive titration using self-monitoring results in lower SBP compared to usual care and whether telemonitoring adds anything to self-monitoring alone. METHODS/DESIGN: This will be a pragmatic primary care based, unblinded, randomised controlled trial of self-monitoring of BP with or without telemonitoring compared to usual care. Eligible patients will have poorly controlled hypertension (>140/90 mmHg) and will be recruited from primary care. Participants will be individually randomised to either usual care, self-monitoring alone, or self-monitoring with telemonitoring. The primary outcome of the trial will be difference in clinic SBP between intervention and control groups at 12 months adjusted for baseline SBP, gender, BP target and practice. At least 1110 patients will be sufficient to detect a difference in SBP between self-monitoring with or without telemonitoring and usual care of 5 mmHg with 90% power with an adjusted alpha of 0.017 (2-sided) to adjust for all three pairwise comparisons. Other outcomes will include adherence of anti-hypertensive medication, lifestyle behaviours, health-related quality of life, and adverse events. An economic analysis will consider both within trial costs and a model extrapolating the results thereafter. A qualitative sub study will gain insights into the views, experiences and decision making processes of patients and health care professionals focusing on the acceptability of self-monitoring and telemonitoring in the routine management of hypertension. DISCUSSION: The results of the trial will be directly applicable to primary care in the UK. If successful, self-monitoring of BP in people with hypertension would be applicable to hundreds of thousands of individuals in the UK. TRIAL REGISTRATION: ISRCTN 83571366 . Registered 17 July 2014.
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- 2017
19. Efficacy of self-monitored blood pressure, with or without telemonitoring, for titration of antihypertensive medication (TASMINH4): an unmasked randomised controlled trial
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McManus, Richard J, primary, Mant, Jonathan, additional, Franssen, Marloes, additional, Nickless, Alecia, additional, Schwartz, Claire, additional, Hodgkinson, James, additional, Bradburn, Peter, additional, Farmer, Andrew, additional, Grant, Sabrina, additional, Greenfield, Sheila M, additional, Heneghan, Carl, additional, Jowett, Susan, additional, Martin, Una, additional, Milner, Siobhan, additional, Monahan, Mark, additional, Mort, Sam, additional, Ogburn, Emma, additional, Perera-Salazar, Rafael, additional, Shah, Syed Ahmar, additional, Yu, Ly-Mee, additional, Tarassenko, Lionel, additional, Hobbs, F D Richard, additional, Bradley, Brendan, additional, Lovekin, Chris, additional, Judge, David, additional, Castello, Luis, additional, Dawson, Maureen, additional, Brice, Rebecca, additional, Dunbabin, Bethany, additional, Maslen, Sophie, additional, Rutter, Heather, additional, Norris, Mary, additional, French, Lauren, additional, Loynd, Michael, additional, Whitbread, Pippa, additional, Saldana Ortaga, Luisa, additional, Noel, Irene, additional, Madronal, Karen, additional, Timmins, Julie, additional, Hughes, Lucy, additional, Hinks, Beth, additional, Bailey, Sheila, additional, Read, Sue, additional, Weston, Andrea, additional, Spannuth, Somi, additional, Maiden, Sue, additional, Chermahini, Makiko, additional, McDonald, Ann, additional, Rajan, Shelina, additional, Allen, Sue, additional, Deboys, Brenda, additional, Fell, Kim, additional, Johnson, Jenny, additional, Jung, Helen, additional, Lister, Rachel, additional, Osborne, Ruth, additional, Secker, Amy, additional, Qasim, Irene, additional, William, Kirsty, additional, Harris, Abi, additional, Zhao, Susan, additional, Butcher, Elaine, additional, Darbyshire, Pauline, additional, Joshi, Sarah, additional, Davies, Jon, additional, Talbot, Claire, additional, Hoverd, Eleanor, additional, Field, Linda, additional, Adcock, Tracey, additional, Rooney, Julia, additional, Cooter, Nina, additional, Butler, Aaron, additional, Allen, Naomi, additional, Abdul-Wahab, Maria, additional, McNicholas, Kathryn, additional, Peniket, Lara, additional, Dodd, Kate, additional, Mugurza, Julie, additional, Baskerville, Richard, additional, Syed, Rakshan, additional, Bailey, Clare, additional, Adams, Jill, additional, Uglow, Paul, additional, Townsend, Neil, additional, Macleod, Alison, additional, Hawkins, Charlotte, additional, Behura, Suparna, additional, Crawshaw, Jonathan, additional, Fox, Robin, additional, Doski, Waleed, additional, Aylward, Martin, additional, A'Court, Christine, additional, Rapley, David, additional, Walsh, Jo, additional, Batra, Paul, additional, Seoane, Ana, additional, Mukherjee, Sluti, additional, Dixon, Jonathan, additional, Arthur, Peter, additional, Sutcliffe, Karen, additional, Paschallides, Costas, additional, Woof, Richard, additional, Winfrey, Peter, additional, Clark, Matthew, additional, Kamali, Roya, additional, Thomas, Paul, additional, Ebbs, David, additional, Mather, Liz, additional, Beattie, Andre, additional, Ladha, Karim, additional, Smondulak, Larisa, additional, Jemahl, Surinder, additional, Hickson, Peter, additional, Stevens, Liam, additional, Crockett, Tony, additional, Shukla, David, additional, Binnian, Ian, additional, Vinson, Paul, additional, DeKare-Silver, Nigel, additional, Patel, Ramila, additional, Singh, Ivor, additional, Lumley, Louise, additional, Williams, Glennis, additional, Webb, Mark, additional, Bambrough, Jack, additional, Shah, Neetul, additional, Dosanjh, Hergeven, additional, Spannuth, Frank, additional, Paul, Carolyn, additional, Ganesegaram, Jude, additional, Pike, Laurie, additional, Maheswaran, Vijaysundari, additional, Paruk, Farah, additional, Ford, Stephen, additional, Verma, Vineeta, additional, Milne, Kate, additional, Lockhat, Farhana, additional, Ferguson, Jennifer, additional, Quirk, Anne-Marie, additional, Wilson, Hugo, additional, Copping, David, additional, Bajallan, Sam, additional, Tanvir, Simria, additional, Khan, Faheem, additional, Alderson, Tom, additional, Ali, Amar, additional, Young, Richard, additional, Chauhan, Umesh, additional, Crockett, Lindsey, additional, McGovern, Louise, additional, Cubitt, Claire, additional, Weatherill, Simon, additional, Tabassum, Abdul, additional, Saunders, Philip, additional, Chauhan, Naresh, additional, Johnson, Samantha, additional, Marok, Inderjit, additional, Sharma, Rajiv, additional, Lumb, William, additional, Tweedale, John, additional, Smith, Ian, additional, Miller, Lawrence, additional, Ahmed, Tanveer, additional, Sanderson, Mark, additional, Jones, Claire, additional, Stokell, Peter, additional, Edwards, Matthew J, additional, Askey, Andrew, additional, Spencer, Jason, additional, Morgan, Kathryn, additional, Knox, Kyle, additional, Baker, Robert, additional, Fisher, Crispin, additional, Halstead, Rachel, additional, Modha, Neil, additional, Buckley, David, additional, Stokell, Catherine, additional, McCabe, John Gerald, additional, Taylor, Jennifer, additional, Nutbeam, Helen, additional, Smith, Richard, additional, MacGregor, Christopher, additional, Davies, Sam, additional, Lindsey, Mark, additional, Cartwright, Simon, additional, Whittle, Jonathan, additional, Colclough, Julie, additional, Crumbie, Alison, additional, Thomas, Nicholas, additional, Premchand, Vattakkatt, additional, Hamid, Rafia, additional, Ali, Zishan, additional, Ward, John, additional, Pinney, Philip, additional, Thurston, Stephen, additional, and Banerjee, Tina, additional
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- 2018
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20. Exercise response in Parkinson’s disease: insights from a cross-sectional comparison with sedentary controls and a per-protocol analysis of a randomised controlled trial
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Mavrommati, Foteini, primary, Collett, Johnny, additional, Franssen, Marloes, additional, Meaney, Andy, additional, Sexton, Claire, additional, Dennis-West, Andrea, additional, Betts, Jill F, additional, Izadi, Hooshang, additional, Bogdanovic, Marko, additional, Tims, Martin, additional, Farmer, Andrew, additional, and Dawes, Helen, additional
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- 2017
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21. Exercise response in Parkinson’s Disease : insights from a cross-sectional comparison with sedentary controls and a per protocol analysis of a randomised controlled trial
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Mavrommati, Foteini, Collett, Johnny, Franssen, Marloes, Meaney, Andy, Sexton, Claire, Dennis- West, Andrea, Farmer, Andrew, Tims, Martin, Izadi, Hooshang, Bogdanovic, Marko, Betts, Jill F., Dawes, Helen, Mavrommati, Foteini, Collett, Johnny, Franssen, Marloes, Meaney, Andy, Sexton, Claire, Dennis- West, Andrea, Farmer, Andrew, Tims, Martin, Izadi, Hooshang, Bogdanovic, Marko, Betts, Jill F., and Dawes, Helen
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Objectives: To investigate the acute and adaptation cardiovascular and metabolic training responses in people with Parkinson’s (pwP). Design: 1) A cross sectional study of exercise response of pwP compared to sedentary controls,2) an interventional study of exercise training in pwP. Setting: Community leisure facilities. Participants: pwP (n=83) & sedentary controls (n=55) Interventions: Study (1) included participants from a two arm parallel single blind phase II Randomised Controlled Trial (RCT), that undertook a baseline maximal incremental exercise test and study (2) included those randomised to the exercise group in the RCT, who completed a six-month weekly exercise programme (n=37). The intervention (study (2) was a prescribed exercise program consisting of sessions lasting 60 minutes, twice a week over a six-month period. The control group followed the same protocol which derived the same cardio respiratory parameters, except the they were instructed to aim for a cadence of ~60rpm and the unloaded phase lasted 3minutes with an initial step of 25watts. Primary and secondary outcome measures: Stepwise incremental exercise test to volitional exhaustion was the primary outcome measure. Results: Study (1) showed higher maximum values for heart rate, VO2l.min-1, VCO2l.min-1 and Ventilation l.min-1 for the control group; Respiratory Exchange Ratio (RER), perceived exertion and O2 Pulse (VO2l.min-1/ HR) did not differ between groups. In study (2), for pwP who adhered to training (n=37), RER increased significantly and although there was no significant change in aerobic capacity or heart rate response, reduced blood pressure was found. Conclusions: An abnormal cardiovascular response to exercise was observed in pwP compared to controls. After the exercise programme, metabolic deficiencies remained for pwP. These observations add to the pathogenic understanding of PD, acknowledge an underling metabolic contribution and support that certain cardiovascular symptoms may i
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- 2017
22. Phase II randomised controlled trial of a 6-month self-managed community exercise programme for people with Parkinson's disease
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Collett, Johnny, primary, Franssen, Marloes, additional, Meaney, Andy, additional, Wade, Derick, additional, Izadi, Hooshang, additional, Tims, Martin, additional, Winward, Charlotte, additional, Bogdanovic, Marko, additional, Farmer, Andrew, additional, and Dawes, Helen, additional
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- 2016
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23. A protocol for the conduct of a multicentre, prospective, randomized superiority trial of surgical versus non-surgical interventions for humeral shaft fractures.
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Franssen M, Achten J, Appelbe D, Costa ML, Dutton S, Mason J, Gould J, Gray A, Rangan A, Sheehan W, Singh H, and Gwilym SE
- Abstract
Aims: Fractures of the humeral shaft represent 3% to 5% of all fractures. The most common treatment for isolated humeral diaphysis fractures in the UK is non-operative using functional bracing, which carries a low risk of complications, but is associated with a longer healing time and a greater risk of nonunion than surgery. There is an increasing trend to surgical treatment, which may lead to quicker functional recovery and lower rates of fracture nonunion than functional bracing. However, surgery carries inherent risk, including infection, bleeding, and nerve damage. The aim of this trial is to evaluate the clinical and cost-effectiveness of functional bracing compared to surgical fixation for the treatment of humeral shaft fractures., Methods: The HUmeral SHaft (HUSH) fracture study is a multicentre, prospective randomized superiority trial of surgical versus non-surgical interventions for humeral shaft fractures in adult patients. Participants will be randomized to receive either functional bracing or surgery. With 334 participants, the trial will have 90% power to detect a clinically important difference for the Disabilities of the Arm, Shoulder and Hand questionnaire score, assuming 20% loss to follow-up. Secondary outcomes will include function, pain, quality of life, complications, cost-effectiveness, time off work, and ability to drive., Discussion: The results of this trial will provide evidence regarding clinical and cost-effectiveness between surgical and non-surgical treatment of humeral shaft fractures. Ethical approval has been obtained from East of England - Cambridge Central Research Ethics Committee. Publication is anticipated to occur in 2024., Competing Interests: J. Achten and M. L. Costa report institutional funding from NIHR and the Wellcome Trust for research into musculoskeletal trauma, unrelated to this study. A. Rangan reports payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events, and support for attending meetings and/or travel from DePuy Johnson & Johnson, unrelated to this study., (© 2024 Franssen et al.)
- Published
- 2024
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24. Telemonitoring and/or self-monitoring of blood pressure in hypertension (TASMINH4): protocol for a randomised controlled trial.
- Author
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Franssen M, Farmer A, Grant S, Greenfield S, Heneghan C, Hobbs R, Hodgkinson J, Jowett S, Mant J, Martin U, Milner S, Monahan M, Ogburn E, Perera-Salazar R, Schwartz C, Yu LM, and McManus RJ
- Subjects
- Antihypertensive Agents therapeutic use, Clinical Protocols, Humans, Hypertension drug therapy, Hypertension physiopathology, Predictive Value of Tests, Primary Health Care, Research Design, Treatment Outcome, United Kingdom, Blood Pressure drug effects, Blood Pressure Determination methods, Blood Pressure Monitoring, Ambulatory, Hypertension diagnosis, Telemedicine methods, Telemetry
- Abstract
Background: Self-monitoring of hypertension is associated with lower systolic blood pressure (SBP). However, evidence for the use of self-monitoring to titrate antihypertensive medication by physicians is equivocal. Furthermore, there is some evidence for the efficacy of telemonitoring in the management of hypertension but it is not clear what this adds over and above self-monitoring. This trial aims to evaluate whether GP led antihypertensive titration using self-monitoring results in lower SBP compared to usual care and whether telemonitoring adds anything to self-monitoring alone., Methods/design: This will be a pragmatic primary care based, unblinded, randomised controlled trial of self-monitoring of BP with or without telemonitoring compared to usual care. Eligible patients will have poorly controlled hypertension (>140/90 mmHg) and will be recruited from primary care. Participants will be individually randomised to either usual care, self-monitoring alone, or self-monitoring with telemonitoring. The primary outcome of the trial will be difference in clinic SBP between intervention and control groups at 12 months adjusted for baseline SBP, gender, BP target and practice. At least 1110 patients will be sufficient to detect a difference in SBP between self-monitoring with or without telemonitoring and usual care of 5 mmHg with 90% power with an adjusted alpha of 0.017 (2-sided) to adjust for all three pairwise comparisons. Other outcomes will include adherence of anti-hypertensive medication, lifestyle behaviours, health-related quality of life, and adverse events. An economic analysis will consider both within trial costs and a model extrapolating the results thereafter. A qualitative sub study will gain insights into the views, experiences and decision making processes of patients and health care professionals focusing on the acceptability of self-monitoring and telemonitoring in the routine management of hypertension., Discussion: The results of the trial will be directly applicable to primary care in the UK. If successful, self-monitoring of BP in people with hypertension would be applicable to hundreds of thousands of individuals in the UK., Trial Registration: ISRCTN 83571366 . Registered 17 July 2014.
- Published
- 2017
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